High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
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Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
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MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 646 | 621 | 554 | 3317 | 275.3 | 19.34 | 19.44 | 28.31 | 251 | 261 | 267 | 272 | 276 | 281 | 286 | 292 | 299 | 0.1007 | 334 | 0.832 | 128.55 | 29.97 | 1 | 0.5108 | 283 | 0.0078 | 11.20 | 5.111 | 0.3312 | 76161.1 | 21200000 | 5910000000 | 1660000000000 | 0.3922 | 0.2458 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0453 | 0.0451 | 0.0652 | 0.0650 | 0.0380 | 0.0307 | 0.0580 | 0.0469 | 0.7935 | 0.8123 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0453 | 0.0451 | 0.0652 | 0.0650 | 0.0380 | 0.0307 | 0.0580 | 0.0469 | 0.7935 | 0.8123 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0067 | 0.0100 | 0.0300 | 0.0533 | 0.0900 | 0.1667 | 0.1333 | 0.1567 | 0.3533 | 7 | 8 | 9 | 9 | 11 | 12 | 15 | 22 | 33 | 0.0979 | 0.55 | 1.508 | 0.4506 | 1178.9 | 161332 | 29100000 | 5860000000 | 0.5686 | 0.1153 | 0.0480 | 0.0687 | 0.1051 | 0.0634 | 0.1471 | 0.0569 | 0.1952 | 0.0838 | 0.2462 | 0.0967 | 0.1532 | 0.1267 | 0.0811 | 0.1590 | 0.0210 | 0.2105 | 0.0030 | 0.1343 | 0.0121 | 0.0433 | 0.0141 | 0.0377 | 0.0121 | 0.0314 | 0.0313 | 0.0328 | 0.0555 | 0.0370 | 0.0757 | 0.0656 | 0.0858 | 0.0628 | 0.1171 | 0.1172 | 0.5964 | 0.5722 | 0.0091 | 0.0139 | 0.0106 | 0.0239 | 0.0152 | 0.0359 | 0.0410 | 0.0478 | 0.0699 | 0.0896 | 0.1307 | 0.1116 | 0.1185 | 0.1116 | 0.1413 | 0.1434 | 0.4635 | 0.4223 | 0.0059 | 0.0059 | 0.0118 | 0.0403 | 0.0557 | 0.0853 | 0.0936 | 0.1256 | 0.5758 | |
MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 284 | 471 | 1555 | 4253 | 401.1 | 47.90 | 19.31 | 18.63 | 332 | 364 | 381 | 394 | 406 | 416 | 429 | 441 | 459 | 0.0997 | 424 | 1.147 | 61.20 | 22.02 | 1 | 0.1016 | 158 | 0.0027 | 20.18 | 6.139 | 0.2451 | 163138.0 | 67200000 | 28000000000 | 11800000000000 | 0.4443 | 0.1979 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0007 | 0.0000 | 0.0028 | 0.0006 | 0.0285 | 0.0239 | 0.0463 | 0.0303 | 0.0484 | 0.0232 | 0.0855 | 0.0342 | 0.7877 | 0.8877 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0007 | 0.0000 | 0.0028 | 0.0006 | 0.0241 | 0.0239 | 0.0345 | 0.0303 | 0.0241 | 0.0232 | 0.0427 | 0.0342 | 0.8711 | 0.8877 | 0.0426 | 0.0000 | 0.1064 | 0.0000 | 0.1064 | 0.0000 | 0.1277 | 0.0000 | 0.2340 | 0.0000 | 0.1702 | 0.0000 | 0.0638 | 0.0000 | 0.1064 | 0.0000 | 0.0426 | 0.0000 | 0.0000 | 0.0060 | 0.0072 | 0.0358 | 0.0656 | 0.1144 | 0.1085 | 0.1323 | 0.5304 | 8 | 10 | 11 | 13 | 14 | 16 | 18 | 23 | 33 | 0.2369 | 0.56 | 2.092 | 0.8275 | 719.8 | 57928.3 | 7540000 | 1230000000 | 0.5877 | 0.1129 | 0.1023 | 0.0171 | 0.1338 | 0.0274 | 0.1250 | 0.0499 | 0.1439 | 0.0846 | 0.1452 | 0.1170 | 0.1351 | 0.1471 | 0.1225 | 0.1498 | 0.0682 | 0.1619 | 0.0240 | 0.2452 | 0.0447 | 0.0107 | 0.0494 | 0.0169 | 0.0353 | 0.0331 | 0.0358 | 0.0562 | 0.0529 | 0.0841 | 0.0764 | 0.1041 | 0.0781 | 0.1013 | 0.1193 | 0.1162 | 0.5082 | 0.4774 | 0.0132 | 0.0162 | 0.0154 | 0.0310 | 0.0209 | 0.0398 | 0.0473 | 0.0516 | 0.0780 | 0.0634 | 0.0978 | 0.1165 | 0.1022 | 0.0870 | 0.1516 | 0.1608 | 0.4736 | 0.4336 | 0.0277 | 0.0317 | 0.0222 | 0.0301 | 0.0586 | 0.0705 | 0.0777 | 0.1474 | 0.5341 | |
MDA-MB-231 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 699 | 471 | 4304 | 9250 | 675.2 | 100.28 | 112.63 | 227.13 | 526 | 609 | 656 | 678 | 694 | 707 | 722 | 740 | 781 | 0.0782 | 723 | 1.058 | 105.04 | 31.11 | 1 | 0.0602 | 259 | 0.0017 | 29.52 | 6.816 | 0.2429 | 465980.0 | 327000000 | 234000000000 | 169000000000000 | 0.4313 | 0.2103 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0008 | 0.0000 | 0.0028 | 0.0000 | 0.0204 | 0.0139 | 0.0353 | 0.0238 | 0.0311 | 0.0120 | 0.0487 | 0.0205 | 0.8609 | 0.9297 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0016 | 0.0000 | 0.0149 | 0.0139 | 0.0259 | 0.0238 | 0.0191 | 0.0120 | 0.0254 | 0.0205 | 0.9130 | 0.9297 | 0.0082 | 0.0000 | 0.0163 | 0.0000 | 0.0245 | 0.0000 | 0.0367 | 0.0000 | 0.0816 | 0.0000 | 0.0857 | 0.0000 | 0.0816 | 0.0000 | 0.1143 | 0.0000 | 0.5510 | 0.0000 | 0.0004 | 0.0015 | 0.0038 | 0.0128 | 0.0342 | 0.0556 | 0.0680 | 0.0992 | 0.7244 | 8 | 10 | 12 | 14 | 17 | 26 | 59 | 148 | 341 | 0.1976 | 21.25 | 3.579 | 0.6813 | 64269.9 | 61100000 | 74500000000 | 106000000000000 | 0.4869 | 0.1485 | 0.0430 | 0.0000 | 0.1471 | 0.0171 | 0.1991 | 0.0910 | 0.1222 | 0.1229 | 0.1357 | 0.1456 | 0.1154 | 0.1581 | 0.1086 | 0.1229 | 0.0633 | 0.1024 | 0.0656 | 0.2400 | 0.0000 | 0.0000 | 0.0008 | 0.0004 | 0.0013 | 0.0011 | 0.0109 | 0.0094 | 0.0419 | 0.0410 | 0.0747 | 0.0556 | 0.0516 | 0.0402 | 0.0763 | 0.0676 | 0.7425 | 0.7847 | 0.0000 | 0.0006 | 0.0010 | 0.0022 | 0.0031 | 0.0028 | 0.0175 | 0.0185 | 0.0577 | 0.0612 | 0.0911 | 0.1021 | 0.0695 | 0.0606 | 0.0901 | 0.0948 | 0.6699 | 0.6571 | 0.0000 | 0.0009 | 0.0032 | 0.0125 | 0.0529 | 0.0779 | 0.0682 | 0.0904 | 0.6939 | |||
MDA-MB-231 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 125 | 813 | 4044 | 8852 | 602.6 | 91.52 | 41.19 | 63.75 | 467 | 546 | 581 | 603 | 621 | 637 | 653 | 670 | 697 | 0.0916 | 811 | 0.861 | 103.18 | 25.63 | 4 | 0.0601 | 243 | 0.0019 | 32.85 | 6.649 | 0.2422 | 371488.0 | 233000000 | 149000000000 | 95900000000000 | 0.4344 | 0.2018 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0006 | 0.0000 | 0.0029 | 0.0008 | 0.0262 | 0.0168 | 0.0455 | 0.0300 | 0.0385 | 0.0173 | 0.0691 | 0.0297 | 0.8172 | 0.9055 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0011 | 0.0008 | 0.0201 | 0.0167 | 0.0321 | 0.0289 | 0.0201 | 0.0157 | 0.0338 | 0.0282 | 0.8928 | 0.9097 | 0.0279 | 0.0000 | 0.0391 | 0.0000 | 0.0615 | 0.1429 | 0.1006 | 0.2857 | 0.1006 | 0.2857 | 0.1564 | 0.2857 | 0.1229 | 0.0000 | 0.0950 | 0.0000 | 0.2961 | 0.0000 | 0.0008 | 0.0021 | 0.0062 | 0.0181 | 0.0402 | 0.0743 | 0.0812 | 0.0952 | 0.6820 | 9 | 11 | 14 | 16 | 19 | 24 | 32 | 45 | 88 | 0.0559 | 3.74 | 3.856 | 0.6364 | 5760.6 | 1520000 | 505000000 | 191000000000 | 0.4879 | 0.1680 | 0.0222 | 0.0179 | 0.0677 | 0.0335 | 0.0812 | 0.0288 | 0.1141 | 0.0594 | 0.1460 | 0.0957 | 0.1470 | 0.0868 | 0.1692 | 0.1094 | 0.1335 | 0.1627 | 0.1190 | 0.4059 | 0.0058 | 0.0099 | 0.0173 | 0.0192 | 0.0142 | 0.0128 | 0.0242 | 0.0271 | 0.0468 | 0.0434 | 0.0560 | 0.0449 | 0.0629 | 0.0545 | 0.0844 | 0.0813 | 0.6884 | 0.7067 | 0.0032 | 0.0069 | 0.0153 | 0.0122 | 0.0159 | 0.0130 | 0.0312 | 0.0298 | 0.0503 | 0.0519 | 0.0751 | 0.0833 | 0.0649 | 0.0596 | 0.0808 | 0.0795 | 0.6635 | 0.6639 | 0.0049 | 0.0113 | 0.0157 | 0.0300 | 0.0458 | 0.0679 | 0.0684 | 0.0915 | 0.6644 | |
MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 349 | 807 | 6538 | 12626 | 588.0 | 86.69 | 128.31 | 222.66 | 469 | 530 | 562 | 584 | 602 | 620 | 637 | 657 | 683 | 0.0673 | 850 | 0.775 | 146.56 | 30.15 | 1 | 0.0509 | 333 | 0.0010 | 44.42 | 7.238 | 0.1938 | 353259.0 | 216000000 | 134000000000 | 83900000000000 | 0.4229 | 0.2180 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0007 | 0.0000 | 0.0030 | 0.0002 | 0.0197 | 0.0106 | 0.0355 | 0.0173 | 0.0365 | 0.0112 | 0.0673 | 0.0176 | 0.8370 | 0.9433 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0015 | 0.0002 | 0.0129 | 0.0106 | 0.0221 | 0.0173 | 0.0201 | 0.0112 | 0.0312 | 0.0176 | 0.9121 | 0.9433 | 0.0276 | 0.0000 | 0.0379 | 0.0000 | 0.0379 | 0.0000 | 0.1241 | 0.0000 | 0.1310 | 0.0000 | 0.1586 | 0.0000 | 0.1241 | 0.0000 | 0.0931 | 0.0000 | 0.2655 | 0.0000 | 0.0011 | 0.0034 | 0.0053 | 0.0169 | 0.0344 | 0.0573 | 0.0655 | 0.0922 | 0.7238 | 11 | 13 | 16 | 21 | 29 | 46 | 87 | 188 | 404 | 0.1397 | 11.93 | 3.675 | 0.6149 | 66036.9 | 54600000 | 58200000000 | 74400000000000 | 0.4876 | 0.1751 | 0.0820 | 0.0077 | 0.2182 | 0.0463 | 0.2753 | 0.1683 | 0.1406 | 0.1143 | 0.1083 | 0.1550 | 0.0849 | 0.1907 | 0.0395 | 0.1066 | 0.0249 | 0.0863 | 0.0264 | 0.1248 | 0.0000 | 0.0005 | 0.0009 | 0.0010 | 0.0026 | 0.0022 | 0.0131 | 0.0124 | 0.0707 | 0.0604 | 0.0993 | 0.0897 | 0.0678 | 0.0592 | 0.1013 | 0.0905 | 0.6443 | 0.6841 | 0.0000 | 0.0004 | 0.0004 | 0.0004 | 0.0039 | 0.0019 | 0.0218 | 0.0250 | 0.0761 | 0.0832 | 0.1208 | 0.1271 | 0.0778 | 0.0847 | 0.1127 | 0.1144 | 0.5866 | 0.5630 | 0.0003 | 0.0003 | 0.0029 | 0.0147 | 0.0809 | 0.1055 | 0.0723 | 0.1125 | 0.6106 | |
BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 153 | 139 | 5758 | 11802 | 360.4 | 40.57 | 302.04 | 287.41 | 307 | 326 | 339 | 350 | 361 | 372 | 383 | 396 | 412 | 0.0835 | 986 | 0.859 | 110.32 | 27.29 | 1 | 0.0455 | 262 | 0.0019 | 22.05 | 6.508 | 0.2365 | 131562.0 | 48600000 | 18200000000 | 6860000000000 | 0.4593 | 0.1900 | 0.0002 | 0.0000 | 0.0006 | 0.0000 | 0.0011 | 0.0000 | 0.0030 | 0.0002 | 0.0199 | 0.0116 | 0.0345 | 0.0200 | 0.0450 | 0.0106 | 0.0849 | 0.0181 | 0.8109 | 0.9396 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0005 | 0.0000 | 0.0025 | 0.0002 | 0.0165 | 0.0116 | 0.0244 | 0.0200 | 0.0244 | 0.0106 | 0.0400 | 0.0181 | 0.8916 | 0.9396 | 0.0419 | 0.0000 | 0.1204 | 0.0000 | 0.1414 | 0.0000 | 0.1204 | 0.0000 | 0.0942 | 0.0000 | 0.1204 | 0.0000 | 0.1099 | 0.0000 | 0.1099 | 0.0000 | 0.1414 | 0.0000 | 0.0027 | 0.0030 | 0.0172 | 0.0320 | 0.0573 | 0.1004 | 0.1018 | 0.1375 | 0.5480 | 23 | 35 | 59 | 111 | 207 | 327 | 442 | 575 | 737 | 0.0095 | 68.30 | 6.730 | 0.3226 | 173824.0 | 123000000 | 98700000000 | 86100000000000 | 0.4300 | 0.1996 | 0.0309 | 0.0016 | 0.1561 | 0.0094 | 0.2346 | 0.0661 | 0.1920 | 0.1351 | 0.1669 | 0.2033 | 0.1068 | 0.2090 | 0.0576 | 0.1286 | 0.0434 | 0.1167 | 0.0117 | 0.1302 | 0.0002 | 0.0000 | 0.0004 | 0.0002 | 0.0011 | 0.0013 | 0.0078 | 0.0063 | 0.0446 | 0.0401 | 0.0822 | 0.0683 | 0.0522 | 0.0435 | 0.0816 | 0.0691 | 0.7299 | 0.7711 | 0.0005 | 0.0003 | 0.0007 | 0.0019 | 0.0032 | 0.0051 | 0.0178 | 0.0177 | 0.0597 | 0.0756 | 0.1097 | 0.1293 | 0.0834 | 0.0942 | 0.1134 | 0.1322 | 0.6116 | 0.5437 | 0.0000 | 0.0002 | 0.0008 | 0.0107 | 0.0530 | 0.0945 | 0.0643 | 0.1014 | 0.6751 | |
BT-20 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 270 | 229 | 650 | 7025 | 1251.1 | 283.87 | 11.58 | 3.56 | 859 | 957 | 1050 | 1150 | 1249 | 1356 | 1450 | 1553 | 1640 | 0.0757 | 532 | 1.003 | 35.47 | 12.37 | 1 | 0.1554 | 101 | 0.0018 | 76.01 | 6.355 | 0.1286 | 1650000.0 | 2260000000 | 3210000000000 | 4.71E+15 | 0.3546 | 0.2714 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0030 | 0.0000 | 0.0861 | 0.0357 | 0.1632 | 0.0683 | 0.0950 | 0.0233 | 0.1424 | 0.0714 | 0.5104 | 0.8012 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0020 | 0.0000 | 0.0405 | 0.0356 | 0.0729 | 0.0681 | 0.0304 | 0.0232 | 0.0547 | 0.0464 | 0.7996 | 0.8266 | 0.0000 | 1.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0127 | 0.0000 | 0.0828 | 0.0000 | 0.1083 | 0.0000 | 0.0573 | 0.0000 | 0.1083 | 0.0000 | 0.6306 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0093 | 0.0556 | 0.0710 | 0.0525 | 0.0556 | 0.7562 | 7 | 9 | 10 | 11 | 11 | 12 | 13 | 14 | 16 | 0.0081 | 16.06 | 5.190 | 0.2777 | 146.9 | 2017.49 | 29808.4 | 471003 | 0.4942 | 0.1529 | 0.0108 | 0.0007 | 0.0396 | 0.0047 | 0.0930 | 0.0132 | 0.1508 | 0.0346 | 0.2124 | 0.0636 | 0.2362 | 0.1307 | 0.1635 | 0.2187 | 0.0792 | 0.3144 | 0.0144 | 0.2194 | 0.0046 | 0.0002 | 0.0197 | 0.0029 | 0.0427 | 0.0088 | 0.0534 | 0.0212 | 0.0813 | 0.0412 | 0.1242 | 0.0726 | 0.1697 | 0.1078 | 0.2247 | 0.2453 | 0.2797 | 0.5001 | 0.1226 | 0.2147 | 0.1534 | 0.1587 | 0.1534 | 0.1635 | 0.1480 | 0.1346 | 0.1180 | 0.1010 | 0.0987 | 0.0737 | 0.0887 | 0.0561 | 0.0717 | 0.0657 | 0.0455 | 0.0321 | 0.0277 | 0.0639 | 0.0858 | 0.1141 | 0.1354 | 0.1515 | 0.1521 | 0.1263 | 0.1433 | |
BT-20 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 765 | 448 | 1036 | 4704 | 600.2 | 210.48 | 6.20 | 1.84 | 332 | 391 | 444 | 509 | 577 | 659 | 743 | 818 | 904 | 0.0897 | 422 | 1.225 | 53.31 | 21.95 | 1 | 0.1332 | 138 | 0.0016 | 24.08 | 6.554 | 0.2404 | 404516.0 | 298000000 | 234000000000 | 192000000000000 | 0.3419 | 0.2894 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0014 | 0.0031 | 0.0043 | 0.1242 | 0.0558 | 0.2329 | 0.1016 | 0.1304 | 0.0629 | 0.1739 | 0.0801 | 0.3354 | 0.6938 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0011 | 0.0392 | 0.0339 | 0.0633 | 0.0532 | 0.0271 | 0.0271 | 0.0542 | 0.0407 | 0.8163 | 0.8439 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0058 | 0.0324 | 0.0585 | 0.0649 | 0.0848 | 0.1135 | 0.0409 | 0.0757 | 0.0673 | 0.0811 | 0.7427 | 0.6324 | 0.0000 | 0.0000 | 0.0021 | 0.0062 | 0.0374 | 0.0811 | 0.0395 | 0.0457 | 0.7879 | 4 | 5 | 5 | 6 | 6 | 7 | 7 | 8 | 8 | 0.0274 | 6.20 | 3.980 | 0.3875 | 41.8 | 302.145 | 2320.55 | 18932.6 | 0.4537 | 0.1856 | 0.0023 | 0.0005 | 0.0113 | 0.0013 | 0.0441 | 0.0090 | 0.1027 | 0.0249 | 0.1782 | 0.0542 | 0.2398 | 0.1111 | 0.2262 | 0.2325 | 0.1613 | 0.3262 | 0.0341 | 0.2402 | 0.0000 | 0.0000 | 0.0017 | 0.0005 | 0.0047 | 0.0016 | 0.0231 | 0.0099 | 0.0540 | 0.0309 | 0.1005 | 0.0574 | 0.1816 | 0.1030 | 0.3028 | 0.2870 | 0.3314 | 0.5097 | 0.1740 | 0.3416 | 0.2290 | 0.2805 | 0.1980 | 0.1584 | 0.1530 | 0.1041 | 0.1140 | 0.0679 | 0.0770 | 0.0181 | 0.0260 | 0.0158 | 0.0230 | 0.0090 | 0.0060 | 0.0045 | 0.0029 | 0.0141 | 0.0417 | 0.0959 | 0.1617 | 0.2172 | 0.2159 | 0.1543 | 0.0962 | |
BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 199 | 260 | 10686 | 24087 | 343.1 | 42.34 | 218.62 | 243.80 | 294 | 309 | 319 | 329 | 339 | 349 | 361 | 376 | 398 | 0.0560 | 1348 | 1.108 | 80.65 | 27.02 | 2 | 0.0188 | 201 | 0.0020 | 20.94 | 6.553 | 0.2495 | 119532.0 | 42300000 | 15200000000 | 5550000000000 | 0.4430 | 0.2105 | 0.0001 | 0.0000 | 0.0002 | 0.0000 | 0.0012 | 0.0000 | 0.0032 | 0.0005 | 0.0194 | 0.0089 | 0.0355 | 0.0176 | 0.0461 | 0.0113 | 0.0755 | 0.0211 | 0.8188 | 0.9407 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0015 | 0.0000 | 0.0114 | 0.0086 | 0.0212 | 0.0159 | 0.0232 | 0.0077 | 0.0352 | 0.0146 | 0.9074 | 0.9532 | 0.0199 | 0.0000 | 0.0385 | 0.0000 | 0.0442 | 0.0000 | 0.0855 | 0.0000 | 0.0954 | 0.0000 | 0.1311 | 0.0000 | 0.1197 | 0.0000 | 0.1211 | 0.0000 | 0.3447 | 0.0000 | 0.0047 | 0.0098 | 0.0155 | 0.0422 | 0.0674 | 0.0986 | 0.1131 | 0.1277 | 0.5211 | 18 | 23 | 29 | 46 | 110 | 198 | 297 | 422 | 589 | 0.0307 | 46.12 | 5.951 | 0.4302 | 107227.0 | 68300000 | 50200000000 | 40800000000000 | 0.5298 | 0.1259 | 0.0245 | 0.0018 | 0.1127 | 0.0149 | 0.2277 | 0.0610 | 0.1750 | 0.0972 | 0.1550 | 0.1809 | 0.1245 | 0.2068 | 0.0732 | 0.1277 | 0.0609 | 0.1204 | 0.0464 | 0.1894 | 0.0000 | 0.0000 | 0.0005 | 0.0002 | 0.0017 | 0.0016 | 0.0077 | 0.0073 | 0.0415 | 0.0338 | 0.0707 | 0.0588 | 0.0495 | 0.0417 | 0.0772 | 0.0625 | 0.7513 | 0.7941 | 0.0004 | 0.0004 | 0.0010 | 0.0016 | 0.0029 | 0.0041 | 0.0139 | 0.0205 | 0.0578 | 0.0653 | 0.0903 | 0.1105 | 0.0763 | 0.0890 | 0.1087 | 0.1110 | 0.6487 | 0.5975 | 0.0001 | 0.0011 | 0.0034 | 0.0105 | 0.0471 | 0.0826 | 0.0615 | 0.0887 | 0.7050 | |
BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 457 | 212 | 6322 | 18147 | 382.8 | 44.78 | 238.77 | 294.82 | 326 | 348 | 362 | 373 | 384 | 395 | 406 | 419 | 439 | 0.0600 | 1088 | 1.215 | 99.36 | 36.50 | 1 | 0.0386 | 244 | 0.0018 | 29.68 | 6.658 | 0.2214 | 148564.0 | 58400000 | 23200000000 | 9350000000000 | 0.4200 | 0.2268 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0005 | 0.0000 | 0.0033 | 0.0005 | 0.0198 | 0.0108 | 0.0385 | 0.0209 | 0.0480 | 0.0104 | 0.0811 | 0.0223 | 0.8084 | 0.9351 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0015 | 0.0005 | 0.0136 | 0.0108 | 0.0260 | 0.0209 | 0.0246 | 0.0104 | 0.0395 | 0.0223 | 0.8947 | 0.9351 | 0.0536 | 0.0000 | 0.0421 | 0.0000 | 0.0651 | 0.0000 | 0.1303 | 0.0000 | 0.1418 | 0.0000 | 0.2222 | 0.0000 | 0.1188 | 0.0000 | 0.1341 | 0.0000 | 0.0920 | 0.0000 | 0.0012 | 0.0049 | 0.0132 | 0.0292 | 0.0679 | 0.1075 | 0.1161 | 0.1588 | 0.5012 | 17 | 22 | 29 | 46 | 89 | 180 | 301 | 457 | 675 | 0.0295 | 57.83 | 5.943 | 0.4328 | 143927.0 | 117000000 | 112000000000 | 121000000000000 | 0.4463 | 0.1845 | 0.0546 | 0.0038 | 0.1914 | 0.0093 | 0.2906 | 0.1053 | 0.1701 | 0.1693 | 0.1184 | 0.2109 | 0.1042 | 0.1922 | 0.0475 | 0.1153 | 0.0156 | 0.0952 | 0.0078 | 0.0987 | 0.0001 | 0.0005 | 0.0011 | 0.0005 | 0.0034 | 0.0014 | 0.0108 | 0.0082 | 0.0532 | 0.0501 | 0.0872 | 0.0742 | 0.0606 | 0.0519 | 0.0872 | 0.0802 | 0.6963 | 0.7330 | 0.0005 | 0.0004 | 0.0021 | 0.0008 | 0.0042 | 0.0052 | 0.0150 | 0.0185 | 0.0656 | 0.0707 | 0.1028 | 0.1137 | 0.0807 | 0.0882 | 0.1081 | 0.1140 | 0.6208 | 0.5885 | 0.0002 | 0.0016 | 0.0046 | 0.0142 | 0.0602 | 0.0943 | 0.0678 | 0.0986 | 0.6586 | |
MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 561 | 247 | 4445 | 15033 | 466.1 | 65.09 | 63.62 | 138.06 | 379 | 413 | 433 | 450 | 466 | 481 | 499 | 521 | 551 | 0.0559 | 840 | 1.186 | 46.40 | 17.49 | 1 | 0.0270 | 120 | 0.0015 | 34.76 | 6.820 | 0.2169 | 221513.0 | 107000000 | 52800000000 | 26400000000000 | 0.4116 | 0.2311 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0035 | 0.0002 | 0.0355 | 0.0137 | 0.0646 | 0.0248 | 0.0635 | 0.0142 | 0.0910 | 0.0205 | 0.7407 | 0.9266 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0020 | 0.0002 | 0.0221 | 0.0137 | 0.0368 | 0.0248 | 0.0314 | 0.0142 | 0.0456 | 0.0187 | 0.8620 | 0.9284 | 0.0110 | 1.0000 | 0.0192 | 0.0000 | 0.0219 | 0.0000 | 0.0959 | 0.0000 | 0.1479 | 0.0000 | 0.1726 | 0.0000 | 0.1397 | 0.0000 | 0.1288 | 0.0000 | 0.2630 | 0.0000 | 0.0004 | 0.0036 | 0.0085 | 0.0278 | 0.0732 | 0.0996 | 0.0961 | 0.1302 | 0.5606 | 7 | 8 | 9 | 10 | 12 | 15 | 22 | 57 | 200 | 0.2619 | 11.61 | 3.053 | 0.7574 | 23105.5 | 14100000 | 11000000000 | 10100000000000 | 0.4691 | 0.1844 | 0.0363 | 0.0081 | 0.0726 | 0.0208 | 0.0726 | 0.0728 | 0.1501 | 0.0786 | 0.1622 | 0.1110 | 0.1671 | 0.1260 | 0.1574 | 0.1191 | 0.1090 | 0.1445 | 0.0726 | 0.3191 | 0.0003 | 0.0012 | 0.0013 | 0.0030 | 0.0023 | 0.0044 | 0.0077 | 0.0094 | 0.0229 | 0.0195 | 0.0265 | 0.0301 | 0.0245 | 0.0248 | 0.0368 | 0.0387 | 0.8777 | 0.8689 | 0.0011 | 0.0000 | 0.0011 | 0.0004 | 0.0022 | 0.0024 | 0.0108 | 0.0091 | 0.0238 | 0.0234 | 0.0309 | 0.0313 | 0.0313 | 0.0317 | 0.0395 | 0.0527 | 0.8593 | 0.8490 | 0.0003 | 0.0007 | 0.0048 | 0.0104 | 0.0214 | 0.0308 | 0.0235 | 0.0443 | 0.8637 | |
MDA-MB-231 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 673 | 661 | 8356 | 21692 | 629.4 | 88.97 | 157.77 | 200.04 | 505 | 558 | 588 | 612 | 637 | 660 | 678 | 703 | 736 | 0.0423 | 917 | 1.088 | 108.30 | 37.05 | 1 | 0.0333 | 278 | 0.0009 | 30.54 | 7.337 | 0.2196 | 404042.0 | 264000000 | 175000000000 | 118000000000000 | 0.4222 | 0.2219 | 0.0003 | 0.0000 | 0.0004 | 0.0000 | 0.0007 | 0.0000 | 0.0036 | 0.0002 | 0.0168 | 0.0091 | 0.0339 | 0.0170 | 0.0309 | 0.0087 | 0.0431 | 0.0141 | 0.8703 | 0.9508 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0017 | 0.0002 | 0.0097 | 0.0091 | 0.0211 | 0.0170 | 0.0174 | 0.0087 | 0.0212 | 0.0141 | 0.9286 | 0.9508 | 0.0052 | 0.0000 | 0.0087 | 0.0000 | 0.0280 | 0.0000 | 0.0332 | 0.0000 | 0.0769 | 0.0000 | 0.1206 | 0.0000 | 0.0962 | 0.0000 | 0.1521 | 0.0000 | 0.4790 | 0.0000 | 0.0011 | 0.0031 | 0.0058 | 0.0105 | 0.0285 | 0.0524 | 0.0515 | 0.0731 | 0.7740 | 10 | 13 | 19 | 33 | 63 | 113 | 189 | 289 | 461 | 0.0633 | 29.43 | 5.277 | 0.5302 | 64906.9 | 36700000 | 24600000000 | 18400000000000 | 0.4278 | 0.2001 | 0.0270 | 0.0020 | 0.1224 | 0.0151 | 0.2282 | 0.0660 | 0.1787 | 0.1115 | 0.1483 | 0.1596 | 0.1201 | 0.2156 | 0.0684 | 0.1388 | 0.0615 | 0.1073 | 0.0454 | 0.1841 | 0.0001 | 0.0003 | 0.0002 | 0.0008 | 0.0015 | 0.0014 | 0.0077 | 0.0098 | 0.0437 | 0.0330 | 0.0678 | 0.0540 | 0.0479 | 0.0450 | 0.0793 | 0.0589 | 0.7519 | 0.7967 | 0.0005 | 0.0000 | 0.0015 | 0.0012 | 0.0026 | 0.0031 | 0.0122 | 0.0151 | 0.0611 | 0.0727 | 0.0953 | 0.1124 | 0.0662 | 0.0769 | 0.1035 | 0.1141 | 0.6570 | 0.6045 | 0.0001 | 0.0010 | 0.0024 | 0.0121 | 0.0486 | 0.0835 | 0.0554 | 0.0881 | 0.7087 | |
MDA-MB-231 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 305 | 753 | 14531 | 31502 | 446.4 | 61.03 | 117.13 | 162.48 | 365 | 402 | 424 | 439 | 452 | 464 | 476 | 491 | 515 | 0.0488 | 1538 | 0.844 | 110.02 | 27.80 | 4 | 0.0189 | 274 | 0.0017 | 18.96 | 6.823 | 0.2707 | 202963.0 | 93800000 | 44000000000 | 21000000000000 | 0.4307 | 0.2135 | 0.0003 | 0.0001 | 0.0001 | 0.0000 | 0.0009 | 0.0000 | 0.0036 | 0.0001 | 0.0149 | 0.0077 | 0.0284 | 0.0166 | 0.0253 | 0.0080 | 0.0383 | 0.0128 | 0.8882 | 0.9547 | 0.0001 | 0.0001 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0019 | 0.0001 | 0.0098 | 0.0077 | 0.0186 | 0.0166 | 0.0149 | 0.0080 | 0.0188 | 0.0117 | 0.9360 | 0.9558 | 0.0148 | 1.0000 | 0.0239 | 0.0000 | 0.0091 | 0.0000 | 0.0262 | 0.0000 | 0.0809 | 0.0000 | 0.0945 | 0.0000 | 0.0809 | 0.0000 | 0.1173 | 0.0000 | 0.5524 | 0.0000 | 0.0022 | 0.0070 | 0.0123 | 0.0187 | 0.0346 | 0.0523 | 0.0642 | 0.0921 | 0.7167 | 13 | 16 | 21 | 33 | 52 | 79 | 118 | 180 | 305 | 0.0400 | 19.55 | 4.937 | 0.5597 | 40119.5 | 22800000 | 16800000000 | 14600000000000 | 0.4801 | 0.1897 | 0.0180 | 0.0019 | 0.0684 | 0.0102 | 0.1417 | 0.0304 | 0.1389 | 0.0605 | 0.1660 | 0.1385 | 0.1648 | 0.1775 | 0.1107 | 0.1263 | 0.1041 | 0.1394 | 0.0873 | 0.3154 | 0.0012 | 0.0003 | 0.0022 | 0.0020 | 0.0034 | 0.0030 | 0.0115 | 0.0124 | 0.0463 | 0.0387 | 0.0745 | 0.0614 | 0.0495 | 0.0472 | 0.0766 | 0.0656 | 0.7348 | 0.7694 | 0.0005 | 0.0007 | 0.0024 | 0.0020 | 0.0066 | 0.0068 | 0.0187 | 0.0217 | 0.0585 | 0.0622 | 0.0953 | 0.1084 | 0.0633 | 0.0699 | 0.0954 | 0.0979 | 0.6595 | 0.6304 | 0.0004 | 0.0017 | 0.0044 | 0.0151 | 0.0498 | 0.0888 | 0.0599 | 0.0831 | 0.6968 | |
MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 149 | 240 | 6671 | 12334 | 390.0 | 50.74 | 109.56 | 270.04 | 317 | 352 | 374 | 389 | 399 | 409 | 419 | 431 | 446 | 0.0712 | 878 | 0.700 | 125.40 | 29.61 | 3 | 0.0475 | 317 | 0.0019 | 22.81 | 6.624 | 0.2349 | 154695.0 | 62200000 | 25300000000 | 10400000000000 | 0.4580 | 0.1948 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0010 | 0.0000 | 0.0037 | 0.0003 | 0.0169 | 0.0112 | 0.0407 | 0.0210 | 0.0412 | 0.0134 | 0.0715 | 0.0187 | 0.8249 | 0.9354 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0005 | 0.0000 | 0.0023 | 0.0003 | 0.0133 | 0.0112 | 0.0316 | 0.0210 | 0.0235 | 0.0134 | 0.0319 | 0.0187 | 0.8969 | 0.9354 | 0.1176 | 0.0000 | 0.1438 | 0.0000 | 0.1373 | 0.0000 | 0.1830 | 0.0000 | 0.1111 | 0.0000 | 0.1569 | 0.0000 | 0.0261 | 0.0000 | 0.0523 | 0.0000 | 0.0719 | 0.0000 | 0.0020 | 0.0033 | 0.0091 | 0.0202 | 0.0463 | 0.0663 | 0.0825 | 0.1189 | 0.6514 | 9 | 11 | 12 | 14 | 15 | 18 | 24 | 59 | 344 | 0.2142 | 6.81 | 2.736 | 0.6641 | 84919.1 | 101000000 | 144000000000 | 229000000000000 | 0.5929 | 0.1077 | 0.0204 | 0.0068 | 0.0980 | 0.0068 | 0.1592 | 0.0492 | 0.1878 | 0.0881 | 0.2082 | 0.1593 | 0.1755 | 0.1864 | 0.1020 | 0.1203 | 0.0367 | 0.1661 | 0.0122 | 0.2169 | 0.0005 | 0.0017 | 0.0019 | 0.0004 | 0.0014 | 0.0034 | 0.0052 | 0.0085 | 0.0331 | 0.0296 | 0.0553 | 0.0525 | 0.0355 | 0.0407 | 0.0766 | 0.0805 | 0.7905 | 0.7827 | 0.0000 | 0.0000 | 0.0000 | 0.0006 | 0.0021 | 0.0017 | 0.0064 | 0.0079 | 0.0380 | 0.0350 | 0.0545 | 0.0599 | 0.0401 | 0.0418 | 0.0866 | 0.0870 | 0.7722 | 0.7662 | 0.0000 | 0.0000 | 0.0020 | 0.0076 | 0.0289 | 0.0613 | 0.0370 | 0.0770 | 0.7863 | |
MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 584 | 956 | 603 | 2463 | 406.2 | 49.35 | 106.45 | 171.74 | 341 | 360 | 374 | 391 | 405 | 421 | 434 | 449 | 475 | 0.1397 | 344 | 0.741 | 102.83 | 29.41 | 1 | 0.4809 | 290 | 0.0035 | 18.91 | 5.793 | 0.2498 | 167409.0 | 70000000 | 29700000000 | 12800000000000 | 0.3625 | 0.2807 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0037 | 0.0000 | 0.0037 | 0.0017 | 0.0608 | 0.0415 | 0.0958 | 0.0630 | 0.0608 | 0.0315 | 0.1105 | 0.0481 | 0.6648 | 0.8143 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0017 | 0.0000 | 0.0034 | 0.0017 | 0.0444 | 0.0415 | 0.0650 | 0.0630 | 0.0342 | 0.0315 | 0.0581 | 0.0481 | 0.7932 | 0.8143 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0952 | 0.0000 | 0.1190 | 0.0000 | 0.1905 | 0.0000 | 0.2381 | 0.0000 | 0.1429 | 0.0000 | 0.1190 | 0.0000 | 0.0952 | 0.0000 | 0.0000 | 0.0000 | 0.0101 | 0.0269 | 0.0842 | 0.1010 | 0.1010 | 0.1279 | 0.5488 | 8 | 10 | 11 | 13 | 15 | 30 | 107 | 188 | 310 | 0.1805 | 23.87 | 3.814 | 0.6487 | 40814.5 | 22400000 | 14400000000 | 10100000000000 | 0.5211 | 0.1245 | 0.0866 | 0.0122 | 0.0551 | 0.0528 | 0.1417 | 0.1098 | 0.2205 | 0.1138 | 0.1575 | 0.1301 | 0.1890 | 0.1707 | 0.0787 | 0.1220 | 0.0236 | 0.1260 | 0.0472 | 0.1626 | 0.0012 | 0.0000 | 0.0000 | 0.0047 | 0.0025 | 0.0070 | 0.0149 | 0.0117 | 0.0532 | 0.0493 | 0.0916 | 0.0880 | 0.0668 | 0.0563 | 0.0693 | 0.0599 | 0.7005 | 0.7230 | 0.0015 | 0.0017 | 0.0000 | 0.0033 | 0.0132 | 0.0132 | 0.0264 | 0.0281 | 0.0543 | 0.0677 | 0.1189 | 0.1254 | 0.0764 | 0.0858 | 0.0837 | 0.1073 | 0.6256 | 0.5677 | 0.0000 | 0.0013 | 0.0040 | 0.0148 | 0.0617 | 0.1074 | 0.0671 | 0.0832 | 0.6604 | |
MDA-MB-231 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 421 | 124 | 5496 | 10543 | 841.5 | 127.28 | 116.18 | 190.68 | 650 | 752 | 803 | 837 | 864 | 891 | 918 | 946 | 983 | 0.0719 | 758 | 0.901 | 57.38 | 16.12 | 1 | 0.0260 | 143 | 0.0008 | 45.33 | 7.373 | 0.1837 | 724381.0 | 635000000 | 565000000000 | 510000000000000 | 0.4046 | 0.2403 | 0.0000 | 0.0000 | 0.0002 | 0.0002 | 0.0004 | 0.0000 | 0.0037 | 0.0006 | 0.0217 | 0.0126 | 0.0354 | 0.0196 | 0.0394 | 0.0116 | 0.0630 | 0.0199 | 0.8361 | 0.9356 | 0.0000 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0000 | 0.0019 | 0.0006 | 0.0126 | 0.0126 | 0.0229 | 0.0196 | 0.0169 | 0.0116 | 0.0272 | 0.0199 | 0.9185 | 0.9356 | 0.0145 | 0.0000 | 0.0364 | 0.0000 | 0.0545 | 0.0000 | 0.1200 | 0.0000 | 0.1200 | 0.0000 | 0.1418 | 0.0000 | 0.1455 | 0.0000 | 0.1091 | 0.0000 | 0.2582 | 0.0000 | 0.0016 | 0.0038 | 0.0047 | 0.0144 | 0.0357 | 0.0510 | 0.0620 | 0.0780 | 0.7489 | 11 | 14 | 18 | 24 | 31 | 47 | 83 | 165 | 375 | 0.1122 | 20.14 | 4.053 | 0.6479 | 49852.9 | 32900000 | 26200000000 | 23500000000000 | 0.4577 | 0.2035 | 0.0423 | 0.0022 | 0.1482 | 0.0186 | 0.2052 | 0.1010 | 0.1580 | 0.1256 | 0.1612 | 0.1330 | 0.1075 | 0.1627 | 0.0749 | 0.1085 | 0.0619 | 0.1226 | 0.0407 | 0.2259 | 0.0007 | 0.0006 | 0.0007 | 0.0012 | 0.0071 | 0.0066 | 0.0172 | 0.0124 | 0.0487 | 0.0469 | 0.0774 | 0.0650 | 0.0551 | 0.0478 | 0.0804 | 0.0728 | 0.7127 | 0.7468 | 0.0000 | 0.0005 | 0.0004 | 0.0014 | 0.0030 | 0.0038 | 0.0179 | 0.0141 | 0.0640 | 0.0756 | 0.0989 | 0.1136 | 0.0648 | 0.0700 | 0.0942 | 0.1103 | 0.6567 | 0.6108 | 0.0000 | 0.0027 | 0.0027 | 0.0170 | 0.0572 | 0.0877 | 0.0634 | 0.0912 | 0.6781 | |
MCF 10A | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 607 | 650 | 808 | 9723 | 822.7 | 285.42 | 10.47 | 10.85 | 493 | 549 | 610 | 675 | 765 | 856 | 972 | 1125 | 1261 | 0.0725 | 705 | 0.565 | 32.65 | 5.00 | 1 | 0.1114 | 90 | 0.0018 | 33.14 | 6.417 | 0.1590 | 758238.0 | 769000000 | 841000000000 | 970000000000000 | 0.3548 | 0.2711 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0038 | 0.0017 | 0.1057 | 0.0517 | 0.2453 | 0.1138 | 0.1057 | 0.0552 | 0.1811 | 0.0845 | 0.3585 | 0.6931 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0020 | 0.0014 | 0.0400 | 0.0332 | 0.0700 | 0.0622 | 0.0280 | 0.0249 | 0.0600 | 0.0443 | 0.8000 | 0.8340 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0070 | 0.0681 | 0.0839 | 0.1021 | 0.1259 | 0.0340 | 0.0420 | 0.0681 | 0.0909 | 0.7277 | 0.6504 | 0.0000 | 0.0000 | 0.0000 | 0.0085 | 0.0538 | 0.0595 | 0.0482 | 0.0680 | 0.7620 | 5 | 6 | 6 | 7 | 8 | 8 | 9 | 11 | 17 | 0.1294 | 0.43 | 1.360 | 0.4878 | 227.2 | 11518.1 | 951002 | 99400000 | 0.4627 | 0.1724 | 0.0445 | 0.0009 | 0.1116 | 0.0040 | 0.1533 | 0.0184 | 0.1904 | 0.0460 | 0.1793 | 0.1011 | 0.1539 | 0.1744 | 0.0974 | 0.2117 | 0.0526 | 0.2479 | 0.0170 | 0.1955 | 0.0262 | 0.0002 | 0.0614 | 0.0026 | 0.0785 | 0.0118 | 0.0849 | 0.0295 | 0.0861 | 0.0688 | 0.0922 | 0.1203 | 0.0968 | 0.1483 | 0.1240 | 0.1897 | 0.3498 | 0.4287 | 0.0345 | 0.0237 | 0.0367 | 0.0266 | 0.0434 | 0.0180 | 0.0579 | 0.0633 | 0.0880 | 0.0957 | 0.1030 | 0.1165 | 0.0935 | 0.1043 | 0.1253 | 0.1288 | 0.4176 | 0.4230 | 0.0560 | 0.0567 | 0.0599 | 0.0685 | 0.0868 | 0.0890 | 0.1015 | 0.1209 | 0.3606 | |
MDA-MB-231 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 406 | 806 | 3869 | 9909 | 688.7 | 123.70 | 61.45 | 130.52 | 523 | 588 | 635 | 670 | 698 | 722 | 743 | 770 | 857 | 0.0768 | 761 | 1.128 | 89.45 | 33.12 | 2 | 0.0605 | 234 | 0.0009 | 60.15 | 7.294 | 0.1719 | 489556.0 | 358000000 | 269000000000 | 207000000000000 | 0.3551 | 0.2759 | 0.0004 | 0.0000 | 0.0004 | 0.0000 | 0.0007 | 0.0000 | 0.0039 | 0.0005 | 0.0389 | 0.0191 | 0.0470 | 0.0343 | 0.0473 | 0.0252 | 0.0666 | 0.0433 | 0.7950 | 0.8776 | 0.0003 | 0.0000 | 0.0003 | 0.0000 | 0.0006 | 0.0000 | 0.0021 | 0.0005 | 0.0251 | 0.0187 | 0.0338 | 0.0305 | 0.0311 | 0.0174 | 0.0429 | 0.0274 | 0.8639 | 0.9056 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0217 | 0.0000 | 0.0522 | 0.0000 | 0.0435 | 0.0000 | 0.0783 | 0.0000 | 0.0696 | 0.0000 | 0.7348 | 0.0000 | 0.0005 | 0.0014 | 0.0048 | 0.0144 | 0.0393 | 0.0672 | 0.0561 | 0.0859 | 0.7303 | 6 | 8 | 9 | 10 | 11 | 13 | 21 | 63 | 186 | 0.1948 | 6.58 | 2.831 | 0.6506 | 20808.7 | 11500000 | 7940000000 | 6280000000000 | 0.3866 | 0.2159 | 0.0387 | 0.0072 | 0.1613 | 0.0273 | 0.2355 | 0.1164 | 0.2065 | 0.1193 | 0.1839 | 0.1379 | 0.0903 | 0.1897 | 0.0548 | 0.1149 | 0.0194 | 0.1379 | 0.0097 | 0.1494 | 0.0005 | 0.0000 | 0.0005 | 0.0008 | 0.0009 | 0.0004 | 0.0147 | 0.0132 | 0.0372 | 0.0371 | 0.0689 | 0.0556 | 0.0358 | 0.0342 | 0.0611 | 0.0671 | 0.7804 | 0.7917 | 0.0000 | 0.0000 | 0.0000 | 0.0017 | 0.0032 | 0.0017 | 0.0118 | 0.0121 | 0.0428 | 0.0537 | 0.0707 | 0.0779 | 0.0386 | 0.0467 | 0.0739 | 0.0848 | 0.7590 | 0.7213 | 0.0005 | 0.0005 | 0.0020 | 0.0125 | 0.0435 | 0.0659 | 0.0390 | 0.0649 | 0.7712 | |
MDA-MB-231 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 587 | 223 | 7211 | 12710 | 578.3 | 90.41 | 89.40 | 111.01 | 452 | 510 | 547 | 574 | 591 | 608 | 625 | 646 | 680 | 0.0629 | 799 | 0.795 | 89.56 | 23.85 | 3 | 0.0344 | 248 | 0.0009 | 62.64 | 7.370 | 0.1958 | 342572.0 | 207000000 | 127000000000 | 79600000000000 | 0.4491 | 0.1905 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0012 | 0.0000 | 0.0041 | 0.0004 | 0.0233 | 0.0117 | 0.0460 | 0.0246 | 0.0364 | 0.0110 | 0.0566 | 0.0202 | 0.8320 | 0.9321 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0005 | 0.0000 | 0.0017 | 0.0004 | 0.0145 | 0.0117 | 0.0316 | 0.0246 | 0.0189 | 0.0110 | 0.0268 | 0.0179 | 0.9057 | 0.9343 | 0.0091 | 1.0000 | 0.0146 | 0.0000 | 0.0183 | 0.0000 | 0.0530 | 0.0000 | 0.0804 | 0.0000 | 0.1005 | 0.0000 | 0.1024 | 0.0000 | 0.0951 | 0.0000 | 0.5265 | 0.0000 | 0.0002 | 0.0019 | 0.0045 | 0.0124 | 0.0426 | 0.0660 | 0.0670 | 0.0881 | 0.7172 | 10 | 14 | 19 | 27 | 40 | 63 | 103 | 156 | 234 | 0.0268 | 20.05 | 5.200 | 0.4970 | 20313.0 | 7180000 | 3310000000 | 1810000000000 | 0.4322 | 0.2068 | 0.0263 | 0.0009 | 0.1259 | 0.0110 | 0.2488 | 0.0568 | 0.1902 | 0.1088 | 0.1746 | 0.1845 | 0.1190 | 0.2039 | 0.0576 | 0.1352 | 0.0371 | 0.1325 | 0.0205 | 0.1664 | 0.0006 | 0.0000 | 0.0021 | 0.0011 | 0.0049 | 0.0034 | 0.0148 | 0.0150 | 0.0490 | 0.0449 | 0.0884 | 0.0752 | 0.0504 | 0.0554 | 0.0762 | 0.0747 | 0.7136 | 0.7303 | 0.0008 | 0.0006 | 0.0022 | 0.0034 | 0.0048 | 0.0079 | 0.0202 | 0.0248 | 0.0619 | 0.0657 | 0.0967 | 0.1116 | 0.0695 | 0.0730 | 0.0948 | 0.0920 | 0.6491 | 0.6210 | 0.0000 | 0.0017 | 0.0031 | 0.0174 | 0.0513 | 0.0911 | 0.0613 | 0.0830 | 0.6913 | |
MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 353 | 558 | 3264 | 13261 | 567.7 | 97.23 | 20.25 | 30.53 | 423 | 480 | 524 | 555 | 578 | 601 | 624 | 651 | 686 | 0.0525 | 696 | 0.829 | 83.26 | 24.17 | 2 | 0.0757 | 247 | 0.0012 | 24.55 | 6.947 | 0.2311 | 331741.0 | 199000000 | 122000000000 | 75900000000000 | 0.3761 | 0.2603 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0013 | 0.0000 | 0.0042 | 0.0015 | 0.0348 | 0.0117 | 0.0809 | 0.0329 | 0.0637 | 0.0151 | 0.0926 | 0.0194 | 0.7227 | 0.9195 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0007 | 0.0000 | 0.0018 | 0.0012 | 0.0138 | 0.0117 | 0.0348 | 0.0322 | 0.0210 | 0.0129 | 0.0246 | 0.0169 | 0.9033 | 0.9251 | 0.0000 | 0.0000 | 0.0134 | 0.0000 | 0.0267 | 0.0000 | 0.0829 | 0.2000 | 0.1337 | 0.2000 | 0.2086 | 0.2000 | 0.1310 | 0.2000 | 0.1230 | 0.2000 | 0.2807 | 0.0000 | 0.0000 | 0.0011 | 0.0022 | 0.0117 | 0.0458 | 0.1011 | 0.0844 | 0.1000 | 0.6536 | 6 | 8 | 9 | 10 | 11 | 13 | 15 | 19 | 43 | 0.3560 | 0.58 | 1.966 | 0.8565 | 1342.4 | 217327 | 52700000 | 15600000000 | 0.5872 | 0.1138 | 0.0827 | 0.0402 | 0.0911 | 0.0460 | 0.0905 | 0.0583 | 0.1079 | 0.0708 | 0.1235 | 0.1009 | 0.1307 | 0.1071 | 0.1589 | 0.1225 | 0.1457 | 0.1493 | 0.0689 | 0.3048 | 0.0327 | 0.0279 | 0.0346 | 0.0300 | 0.0335 | 0.0375 | 0.0372 | 0.0451 | 0.0380 | 0.0643 | 0.0515 | 0.0758 | 0.0560 | 0.0781 | 0.0861 | 0.0967 | 0.6304 | 0.5445 | 0.0142 | 0.0053 | 0.0137 | 0.0053 | 0.0132 | 0.0107 | 0.0179 | 0.0165 | 0.0189 | 0.0256 | 0.0344 | 0.0373 | 0.0387 | 0.0453 | 0.0783 | 0.0719 | 0.7708 | 0.7821 | 0.0197 | 0.0239 | 0.0239 | 0.0337 | 0.0322 | 0.0405 | 0.0348 | 0.0594 | 0.7319 | |
BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1060 | 312 | 8531 | 15239 | 406.2 | 51.13 | 226.15 | 245.25 | 342 | 364 | 380 | 392 | 404 | 416 | 431 | 449 | 474 | 0.0668 | 1018 | 0.868 | 57.87 | 17.89 | 1 | 0.0178 | 152 | 0.0013 | 38.37 | 6.954 | 0.1978 | 167626.0 | 70200000 | 29900000000 | 12900000000000 | 0.4561 | 0.1965 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0013 | 0.0000 | 0.0042 | 0.0000 | 0.0191 | 0.0097 | 0.0469 | 0.0162 | 0.0566 | 0.0088 | 0.0892 | 0.0171 | 0.7825 | 0.9482 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0011 | 0.0000 | 0.0126 | 0.0097 | 0.0255 | 0.0162 | 0.0268 | 0.0088 | 0.0439 | 0.0152 | 0.8900 | 0.9501 | 0.0146 | 1.0000 | 0.0419 | 0.0000 | 0.0419 | 0.0000 | 0.1129 | 0.0000 | 0.1548 | 0.0000 | 0.1876 | 0.0000 | 0.1220 | 0.0000 | 0.1275 | 0.0000 | 0.1967 | 0.0000 | 0.0026 | 0.0043 | 0.0115 | 0.0412 | 0.0740 | 0.1178 | 0.1135 | 0.1283 | 0.5068 | 15 | 19 | 31 | 68 | 137 | 220 | 311 | 421 | 569 | 0.0214 | 62.72 | 6.209 | 0.3748 | 111286.0 | 74000000 | 60400000000 | 58100000000000 | 0.5099 | 0.1391 | 0.0526 | 0.0022 | 0.1940 | 0.0114 | 0.2544 | 0.1134 | 0.1674 | 0.1438 | 0.1298 | 0.1878 | 0.1032 | 0.1837 | 0.0545 | 0.1188 | 0.0292 | 0.1096 | 0.0149 | 0.1292 | 0.0000 | 0.0001 | 0.0001 | 0.0004 | 0.0007 | 0.0003 | 0.0079 | 0.0047 | 0.0500 | 0.0399 | 0.0844 | 0.0694 | 0.0697 | 0.0522 | 0.1028 | 0.0844 | 0.6841 | 0.7486 | 0.0000 | 0.0004 | 0.0002 | 0.0009 | 0.0027 | 0.0049 | 0.0148 | 0.0281 | 0.0769 | 0.0926 | 0.1317 | 0.1530 | 0.1039 | 0.1070 | 0.1377 | 0.1459 | 0.5322 | 0.4672 | 0.0000 | 0.0000 | 0.0020 | 0.0090 | 0.0602 | 0.1073 | 0.0860 | 0.1254 | 0.6102 | |
MDA-MB-231 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 200 | 513 | 11296 | 11224 | 660.4 | 94.02 | 95.02 | 136.71 | 543 | 587 | 617 | 640 | 661 | 683 | 708 | 735 | 774 | 0.1009 | 1133 | 0.918 | 133.74 | 44.91 | 2 | 0.0313 | 353 | 0.0006 | 79.90 | 7.739 | 0.1635 | 444990.0 | 305000000 | 213000000000 | 152000000000000 | 0.4251 | 0.2228 | 0.0000 | 0.0000 | 0.0005 | 0.0000 | 0.0017 | 0.0000 | 0.0042 | 0.0006 | 0.0187 | 0.0081 | 0.0399 | 0.0182 | 0.0436 | 0.0113 | 0.0656 | 0.0181 | 0.8257 | 0.9436 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0006 | 0.0000 | 0.0022 | 0.0004 | 0.0107 | 0.0077 | 0.0240 | 0.0167 | 0.0219 | 0.0084 | 0.0314 | 0.0139 | 0.9090 | 0.9530 | 0.0074 | 0.0816 | 0.0173 | 0.0204 | 0.0222 | 0.0408 | 0.0937 | 0.2245 | 0.0912 | 0.2245 | 0.1307 | 0.2041 | 0.1097 | 0.0816 | 0.1233 | 0.1224 | 0.4044 | 0.0000 | 0.0016 | 0.0026 | 0.0092 | 0.0209 | 0.0527 | 0.0772 | 0.0800 | 0.1071 | 0.6486 | 12 | 16 | 20 | 27 | 38 | 53 | 81 | 138 | 272 | 0.0564 | 8.94 | 4.344 | 0.6275 | 27717.6 | 13300000 | 8080000000 | 5720000000000 | 0.4886 | 0.1747 | 0.0110 | 0.0020 | 0.0386 | 0.0109 | 0.0684 | 0.0288 | 0.1323 | 0.0387 | 0.2183 | 0.1107 | 0.1940 | 0.1846 | 0.1147 | 0.1166 | 0.1422 | 0.1509 | 0.0805 | 0.3568 | 0.0009 | 0.0007 | 0.0031 | 0.0037 | 0.0037 | 0.0072 | 0.0119 | 0.0120 | 0.0417 | 0.0400 | 0.0716 | 0.0744 | 0.0409 | 0.0423 | 0.0707 | 0.0596 | 0.7555 | 0.7601 | 0.0008 | 0.0004 | 0.0011 | 0.0022 | 0.0042 | 0.0043 | 0.0168 | 0.0173 | 0.0348 | 0.0381 | 0.0880 | 0.0934 | 0.0513 | 0.0510 | 0.0677 | 0.0636 | 0.7353 | 0.7297 | 0.0007 | 0.0010 | 0.0036 | 0.0116 | 0.0416 | 0.0819 | 0.0459 | 0.0714 | 0.7423 | |
MDA-MB-231 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 431 | 339 | 3943 | 10483 | 650.4 | 93.20 | 77.12 | 134.86 | 524 | 578 | 611 | 637 | 655 | 676 | 697 | 725 | 765 | 0.0630 | 660 | 1.066 | 99.30 | 32.65 | 1 | 0.0621 | 245 | 0.0013 | 29.21 | 6.926 | 0.2389 | 431670.0 | 292000000 | 201000000000 | 140000000000000 | 0.4337 | 0.2092 | 0.0006 | 0.0000 | 0.0003 | 0.0000 | 0.0012 | 0.0000 | 0.0043 | 0.0003 | 0.0239 | 0.0147 | 0.0347 | 0.0234 | 0.0340 | 0.0127 | 0.0534 | 0.0226 | 0.8476 | 0.9264 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0020 | 0.0003 | 0.0148 | 0.0147 | 0.0235 | 0.0234 | 0.0179 | 0.0127 | 0.0277 | 0.0226 | 0.9140 | 0.9264 | 0.0065 | 0.0000 | 0.0065 | 0.0000 | 0.0226 | 0.0000 | 0.0355 | 0.0000 | 0.1000 | 0.0000 | 0.0871 | 0.0000 | 0.1065 | 0.0000 | 0.1290 | 0.0000 | 0.5065 | 0.0000 | 0.0000 | 0.0038 | 0.0072 | 0.0191 | 0.0401 | 0.0558 | 0.0615 | 0.0873 | 0.7252 | 6 | 8 | 9 | 11 | 14 | 22 | 53 | 125 | 238 | 0.1380 | 10.00 | 3.574 | 0.6077 | 24132.5 | 11700000 | 7110000000 | 4930000000000 | 0.4308 | 0.2239 | 0.0546 | 0.0060 | 0.1513 | 0.0313 | 0.2122 | 0.0625 | 0.1912 | 0.1159 | 0.1639 | 0.1915 | 0.1261 | 0.1935 | 0.0630 | 0.1381 | 0.0315 | 0.1190 | 0.0063 | 0.1421 | 0.0010 | 0.0000 | 0.0017 | 0.0015 | 0.0024 | 0.0033 | 0.0102 | 0.0118 | 0.0453 | 0.0386 | 0.0572 | 0.0477 | 0.0437 | 0.0443 | 0.0670 | 0.0641 | 0.7716 | 0.7887 | 0.0000 | 0.0000 | 0.0012 | 0.0000 | 0.0020 | 0.0017 | 0.0113 | 0.0139 | 0.0577 | 0.0582 | 0.0658 | 0.0747 | 0.0516 | 0.0595 | 0.0791 | 0.0860 | 0.7313 | 0.7059 | 0.0004 | 0.0000 | 0.0015 | 0.0127 | 0.0470 | 0.0601 | 0.0548 | 0.0660 | 0.7576 | |||
MDA-MB-231 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 910 | 235 | 5650 | 9484 | 613.1 | 99.25 | 15.85 | 17.71 | 472 | 537 | 575 | 601 | 623 | 643 | 663 | 690 | 733 | 0.0777 | 737 | 0.760 | 87.05 | 15.26 | 1 | 0.0388 | 219 | 0.0011 | 30.87 | 7.107 | 0.2252 | 385716.0 | 248000000 | 163000000000 | 109000000000000 | 0.3922 | 0.2485 | 0.0005 | 0.0000 | 0.0002 | 0.0000 | 0.0016 | 0.0000 | 0.0043 | 0.0007 | 0.0256 | 0.0133 | 0.0488 | 0.0204 | 0.0442 | 0.0136 | 0.0551 | 0.0226 | 0.8197 | 0.9294 | 0.0002 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0012 | 0.0007 | 0.0151 | 0.0133 | 0.0258 | 0.0204 | 0.0208 | 0.0122 | 0.0270 | 0.0190 | 0.9099 | 0.9344 | 0.0036 | 0.2000 | 0.0145 | 0.8000 | 0.0163 | 0.0000 | 0.0435 | 0.0000 | 0.0870 | 0.0000 | 0.1431 | 0.0000 | 0.0833 | 0.0000 | 0.1105 | 0.0000 | 0.4982 | 0.0000 | 0.0019 | 0.0019 | 0.0061 | 0.0129 | 0.0399 | 0.0633 | 0.0672 | 0.0987 | 0.7081 | 5 | 7 | 8 | 9 | 11 | 13 | 15 | 20 | 32 | 0.2512 | 0.44 | 1.751 | 0.7487 | 564.9 | 50306.4 | 9130000 | 2400000000 | 0.5918 | 0.0979 | 0.0534 | 0.0357 | 0.0820 | 0.0510 | 0.0996 | 0.0522 | 0.1245 | 0.0695 | 0.1572 | 0.0948 | 0.1789 | 0.1024 | 0.1727 | 0.1371 | 0.1011 | 0.1779 | 0.0306 | 0.2793 | 0.0244 | 0.0248 | 0.0307 | 0.0322 | 0.0359 | 0.0315 | 0.0432 | 0.0424 | 0.0663 | 0.0619 | 0.0788 | 0.0696 | 0.0772 | 0.0803 | 0.1043 | 0.1080 | 0.5391 | 0.5493 | 0.0219 | 0.0129 | 0.0172 | 0.0233 | 0.0256 | 0.0259 | 0.0339 | 0.0291 | 0.0516 | 0.0505 | 0.0793 | 0.0627 | 0.0652 | 0.0524 | 0.0814 | 0.0996 | 0.6239 | 0.6436 | 0.0286 | 0.0414 | 0.0352 | 0.0447 | 0.0521 | 0.0660 | 0.0663 | 0.1015 | 0.5642 | |||
MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 182 | 324 | 4862 | 8847 | 382.1 | 46.56 | 84.31 | 223.89 | 321 | 348 | 363 | 376 | 385 | 395 | 406 | 419 | 440 | 0.0849 | 751 | 0.869 | 141.40 | 42.45 | 2 | 0.0755 | 367 | 0.0020 | 27.89 | 6.580 | 0.2423 | 148135.0 | 58200000 | 23200000000 | 9310000000000 | 0.4327 | 0.2087 | 0.0002 | 0.0000 | 0.0002 | 0.0000 | 0.0009 | 0.0000 | 0.0044 | 0.0000 | 0.0215 | 0.0134 | 0.0430 | 0.0245 | 0.0423 | 0.0117 | 0.0642 | 0.0210 | 0.8233 | 0.9294 | 0.0002 | 0.0000 | 0.0002 | 0.0000 | 0.0000 | 0.0000 | 0.0018 | 0.0000 | 0.0153 | 0.0134 | 0.0306 | 0.0245 | 0.0237 | 0.0117 | 0.0317 | 0.0210 | 0.8966 | 0.9294 | 0.0214 | 0.0000 | 0.0856 | 0.0000 | 0.1016 | 0.0000 | 0.1283 | 0.0000 | 0.1176 | 0.0000 | 0.1444 | 0.0000 | 0.1016 | 0.0000 | 0.1123 | 0.0000 | 0.1872 | 0.0000 | 0.0019 | 0.0049 | 0.0106 | 0.0314 | 0.0538 | 0.0947 | 0.0981 | 0.1163 | 0.5883 | 8 | 9 | 11 | 12 | 13 | 15 | 20 | 43 | 199 | 0.1434 | 6.44 | 2.531 | 0.5616 | 57228.9 | 60400000 | 73600000000 | 96900000000000 | 0.7057 | 0.0462 | 0.0466 | 0.0000 | 0.0975 | 0.0157 | 0.2458 | 0.0747 | 0.1144 | 0.1041 | 0.1653 | 0.1434 | 0.1483 | 0.1945 | 0.1102 | 0.1611 | 0.0466 | 0.1336 | 0.0254 | 0.1729 | 0.0007 | 0.0000 | 0.0000 | 0.0012 | 0.0014 | 0.0048 | 0.0144 | 0.0133 | 0.0390 | 0.0387 | 0.0787 | 0.0678 | 0.0568 | 0.0599 | 0.1026 | 0.0998 | 0.7066 | 0.7145 | 0.0000 | 0.0000 | 0.0000 | 0.0035 | 0.0016 | 0.0009 | 0.0122 | 0.0192 | 0.0636 | 0.0603 | 0.0865 | 0.0857 | 0.0530 | 0.0594 | 0.1117 | 0.0970 | 0.6713 | 0.6740 | 0.0000 | 0.0008 | 0.0023 | 0.0129 | 0.0530 | 0.0802 | 0.0560 | 0.1104 | 0.6846 |