High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)

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Cell SM Name Small Mol Concentration Small Mol Conc Unit Other Reagent 1 Name Other Reagent 1 Detection Channel Other Reagent 2 Name Other Reagent 2 Detection Channel Row Column Field X-coordinate Y-coordinate Image Nuclear area (pixels) Cytoplasm area (pixels) Nuclear intensity (AU) Std Dev of nuclear intensity (AU) Cytoplasm intensity (AU) Std Dev of cytoplasm intensity (AU) 10% quantile of nuclear intensity (AU) 20% quantile of nuclear intensity (AU) 30% quantile of nuclear intensity (AU) 40% quantile of nuclear intensity (AU) 50% quantile of nuclear intensity (AU) 60% quantile of nuclear intensity (AU) 70% quantile of nuclear intensity (AU) 80% quantile of nuclear intensity (AU) 90% quantile of nuclear intensity (AU) Ratio of cytoplasm perimeter to area Cytoplasm perimeter (pixels) Nuclear roundness Nuclear length (pixels) Nuclear halfwidth (pixels) Number of nuclei Ratio of nuclear perimeter to area Nuclear perimeter (pixels) Nuclear Haralick ASM Nuclear Haralick contrast Nuclear Haralick entropy Nuclear Haralick IDM Nuclear Haralick moment 2 Nuclear Haralick moment 3 Nuclear Haralick moment 4 Nuclear Haralick moment 5 Nuclear radial moment (border) Nuclear radial moment (center) Nuclear Threshold Adj Stat 1 (Threshold: 0.2) Nuclear Threshold Adj Stat 1 (Threshold: 0.4) Nuclear Threshold Adj Stat 2 (Threshold: 0.2) Nuclear Threshold Adj Stat 2 (Threshold: 0.4) Nuclear Threshold Adj Stat 3 (Threshold: 0.2) Nuclear Threshold Adj Stat 3 (Threshold: 0.4) Nuclear Threshold Adj Stat 4 (Threshold: 0.2) Nuclear Threshold Adj Stat 4 (Threshold: 0.4) Nuclear Threshold Adj Stat 5 (Threshold: 0.2) Nuclear Threshold Adj Stat 5 (Threshold: 0.4) Nuclear Threshold Adj Stat 6 (Threshold: 0.2) Nuclear Threshold Adj Stat 6 (Threshold: 0.4) Nuclear Threshold Adj Stat 7 (Threshold: 0.2) Nuclear Threshold Adj Stat 7 (Threshold: 0.4) Nuclear Threshold Adj Stat 8 (Threshold: 0.2) Nuclear Threshold Adj Stat 8 (Threshold: 0.4) Nuclear Threshold Adj Stat 9 (Threshold: 0.2) Nuclear Threshold Adj Stat 9 (Threshold: 0.4) Nuclear Threshold Adj Stat 10 (Threshold: 0.2) Nuclear Threshold Adj Stat 10 (Threshold: 0.4) Nuclear Threshold Adj Stat 11 (Threshold: 0.2) Nuclear Threshold Adj Stat 11 (Threshold: 0.4) Nuclear Threshold Adj Stat 12 (Threshold: 0.2) Nuclear Threshold Adj Stat 12 (Threshold: 0.4) Nuclear Threshold Adj Stat 13 (Threshold: 0.2) Nuclear Threshold Adj Stat 13 (Threshold: 0.4) Nuclear Threshold Adj Stat 14 (Threshold: 0.2) Nuclear Threshold Adj Stat 14 (Threshold: 0.4) Nuclear Threshold Adj Stat 15 (Threshold: 0.2) Nuclear Threshold Adj Stat 15 (Threshold: 0.4) Nuclear Threshold Adj Stat 16 (Threshold: 0.2) Nuclear Threshold Adj Stat 16 (Threshold: 0.4) Nuclear Threshold Adj Stat 17 (Threshold: 0.2) Nuclear Threshold Adj Stat 17 (Threshold: 0.4) Nuclear Threshold Adj Stat 18 (Threshold: 0.2) Nuclear Threshold Adj Stat 18 (Threshold: 0.4) Nuclear Threshold Adj Stat 19 (Threshold: 0.2) Nuclear Threshold Adj Stat 19 (Threshold: 0.4) Nuclear Threshold Adj Stat 20 (Threshold: 0.2) Nuclear Threshold Adj Stat 20 (Threshold: 0.4) Nuclear Threshold Adj Stat 21 (Threshold: 0.2) Nuclear Threshold Adj Stat 21 (Threshold: 0.4) Nuclear Threshold Adj Stat 22 (Threshold: 0.2) Nuclear Threshold Adj Stat 22 (Threshold: 0.4) Nuclear Threshold Adj Stat 23 (Threshold: 0.2) Nuclear Threshold Adj Stat 23 (Threshold: 0.4) Nuclear Threshold Adj Stat 24 (Threshold: 0.2) Nuclear Threshold Adj Stat 24 (Threshold: 0.4) Nuclear Threshold Adj Stat 25 (Threshold: 0.2) Nuclear Threshold Adj Stat 25 (Threshold: 0.4) Nuclear Threshold Adj Stat 26 (Threshold: 0.2) Nuclear Threshold Adj Stat 26 (Threshold: 0.4) Nuclear Threshold Adj Stat 27 (Threshold: 0.2) Nuclear Threshold Adj Stat 27 (Threshold: 0.4) Nuclear Threshold Adj Stat 28 Nuclear Threshold Adj Stat 29 Nuclear Threshold Adj Stat 30 Nuclear Threshold Adj Stat 31 Nuclear Threshold Adj Stat 32 Nuclear Threshold Adj Stat 33 Nuclear Threshold Adj Stat 34 Nuclear Threshold Adj Stat 35 Nuclear Threshold Adj Stat 36 10% quantile of cytoplasm intensity (AU) 20% quantile of cytoplasm intensity (AU) 30% quantile of cytoplasm intensity (AU) 40% quantile of cytoplasm intensity (AU) 50% quantile of cytoplasm intensity (AU) 60% quantile of cytoplasm intensity (AU) 70% quantile of cytoplasm intensity (AU) 80% quantile of cytoplasm intensity (AU) 90% quantile of cytoplasm intensity (AU) Cytoplasmic Haralick ASM Cytoplasmic Haralick contrast Cytoplasmic Haralick entropy Cytoplasmic Haralick IDM Cytoplasmic Haralick moment 2 Cytoplasmic Haralick moment 3 Cytoplasmic Haralick moment 4 Cytoplasmic Haralick moment 5 Cytoplasmic radial moment (border) Cytoplasmic radial moment (center) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 28 Cytoplasmic Threshold Adj Stat 29 Cytoplasmic Threshold Adj Stat 30 Cytoplasmic Threshold Adj Stat 31 Cytoplasmic Threshold Adj Stat 32 Cytoplasmic Threshold Adj Stat 33 Cytoplasmic Threshold Adj Stat 34 Cytoplasmic Threshold Adj Stat 35 Cytoplasmic Threshold Adj Stat 36
MDA-MB-231 A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 354 420 image if available 1298 8819 703.5 137.06 40.06 42.60 498 566 622 685 723 762 800 837 868 0.0693 611 0.939 34.21 8.06 4 0.0624 81 0.0013 60.83 6.801 0.1510 513652.0
387000000
299000000000
236000000000000
0.4003 0.2202 0.0000 0.0000 0.0012 0.0000 0.0012 0.0000 0.0085 0.0008 0.0932 0.0281 0.1538 0.0532 0.1356 0.0258 0.1586 0.0446 0.4479 0.8475 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0019 0.0008 0.0458 0.0281 0.0715 0.0532 0.0372 0.0258 0.0696 0.0446 0.7741 0.8475 0.0045 0.0000 0.0135 0.0000 0.0269 0.0000 0.0628 0.0000 0.1704 0.0000 0.1883 0.0000 0.1390 0.0000 0.1749 0.0000 0.2197 0.0000 0.0000 0.0000 0.0014 0.0124 0.0634 0.1007 0.0703 0.1131 0.6386 12 14 16 19 24 30 39 56 96 0.0579 5.04 3.928 0.6486 3419.8
510086
108000000
28300000000
0.4195 0.2154 0.0197 0.0099 0.0599 0.0129 0.1125 0.0254 0.1289 0.0420 0.1724 0.0884 0.1634 0.1256 0.1330 0.1219 0.1371 0.1819 0.0731 0.3921 0.0057 0.0056 0.0106 0.0065 0.0157 0.0127 0.0205 0.0169 0.0410 0.0340 0.0651 0.0498 0.0576 0.0514 0.0923 0.0910 0.6916 0.7322 0.0014 0.0017 0.0062 0.0028 0.0105 0.0062 0.0253 0.0258 0.0581 0.0624 0.0781 0.0983 0.0696 0.0736 0.0948 0.0893 0.6560 0.6399 0.0019 0.0054 0.0101 0.0260 0.0490 0.0707 0.0634 0.1014 0.6720
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 259 595 image if available 3281 8845 537.2 98.78 47.70 69.98 406 455 487 513 535 555 578 608 681 0.0684 605 1.005 109.84 37.48 2 0.0884 290 0.0012 24.77 6.942 0.2330 298323.0
171000000
101000000000
61500000000000
0.4559 0.1915 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0076 0.0006 0.0295 0.0159 0.0565 0.0312 0.0510 0.0243 0.0674 0.0328 0.7880 0.8952 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0039 0.0006 0.0159 0.0128 0.0297 0.0253 0.0244 0.0131 0.0304 0.0186 0.8956 0.9295 0.0066 0.0137 0.0088 0.0274 0.0243 0.0959 0.0133 0.0959 0.0575 0.2055 0.0973 0.1507 0.0619 0.1096 0.0841 0.1507 0.6460 0.1507 0.0012 0.0000 0.0025 0.0204 0.0532 0.0835 0.0884 0.1070 0.6438 8 9 11 12 14 19 46 78 131 0.2066 2.60 3.143 0.7617 7171.8
1810000
603000000
239000000000
0.5155 0.1378 0.0352 0.0029 0.0580 0.0155 0.0890 0.0638 0.1201 0.0629 0.1532 0.0977 0.1636 0.1460 0.1822 0.1199 0.1387 0.1586 0.0600 0.3327 0.0007 0.0007 0.0014 0.0020 0.0021 0.0029 0.0064 0.0085 0.0152 0.0186 0.0258 0.0232 0.0237 0.0235 0.0488 0.0405 0.8759 0.8803 0.0017 0.0015 0.0009 0.0039 0.0064 0.0064 0.0111 0.0148 0.0273 0.0261 0.0413 0.0542 0.0388 0.0473 0.0725 0.0719 0.8001 0.7740 0.0008 0.0008 0.0035 0.0096 0.0207 0.0261 0.0337 0.0560 0.8489
MCF 10A A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 273 873 image if available 959 20054 113.6 15.41 28.35 38.32 95 99 103 107 113 117 121 127 135 0.0524 1050 1.034 39.40 13.04 0 0.1064 102 0.0763 0.50 2.832 0.7708 13136.1
1550000
186000000
22800000000
0.4056 0.2400 0.0012 0.0000 0.0036 0.0010 0.0083 0.0031 0.0154 0.0073 0.0473 0.0241 0.0746 0.0640 0.0734 0.0325 0.1006 0.0598 0.6757 0.8080 0.0011 0.0000 0.0032 0.0010 0.0076 0.0031 0.0108 0.0073 0.0314 0.0229 0.0541 0.0615 0.0400 0.0250 0.0639 0.0532 0.7879 0.8259 0.0000 0.0000 0.0127 0.1667 0.0506 0.0000 0.1013 0.5000 0.1266 0.3333 0.1392 0.0000 0.1266 0.0000 0.1266 0.0000 0.3165 0.0000 0.0022 0.0043 0.0152 0.0260 0.0390 0.0758 0.0736 0.1017 0.6623 11 13 15 17 20 22 26 31 40 0.3245 0.91 1.880 0.8551 2272.4
507754
174000000
71000000000
0.5696 0.1296 0.0433 0.0176 0.0600 0.0218 0.0785 0.0264 0.1039 0.0386 0.1265 0.0642 0.1678 0.0809 0.1887 0.1079 0.1421 0.1846 0.0893 0.4581 0.0240 0.0144 0.0282 0.0178 0.0330 0.0204 0.0353 0.0280 0.0502 0.0467 0.0618 0.0603 0.0746 0.0721 0.1061 0.1150 0.5867 0.6253 0.0284 0.0348 0.0315 0.0221 0.0495 0.0172 0.0486 0.0255 0.0769 0.0594 0.0874 0.0790 0.0867 0.0795 0.1126 0.1286 0.4784 0.5540 0.0222 0.0261 0.0286 0.0380 0.0551 0.0752 0.0968 0.1505 0.5076
MDA-MB-231 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 200 513 image if available 11296 11224 660.4 94.02 95.02 136.71 543 587 617 640 661 683 708 735 774 0.1009 1133 0.918 133.74 44.91 2 0.0313 353 0.0006 79.90 7.739 0.1635 444990.0
305000000
213000000000
152000000000000
0.4251 0.2228 0.0000 0.0000 0.0005 0.0000 0.0017 0.0000 0.0042 0.0006 0.0187 0.0081 0.0399 0.0182 0.0436 0.0113 0.0656 0.0181 0.8257 0.9436 0.0000 0.0000 0.0002 0.0000 0.0006 0.0000 0.0022 0.0004 0.0107 0.0077 0.0240 0.0167 0.0219 0.0084 0.0314 0.0139 0.9090 0.9530 0.0074 0.0816 0.0173 0.0204 0.0222 0.0408 0.0937 0.2245 0.0912 0.2245 0.1307 0.2041 0.1097 0.0816 0.1233 0.1224 0.4044 0.0000 0.0016 0.0026 0.0092 0.0209 0.0527 0.0772 0.0800 0.1071 0.6486 12 16 20 27 38 53 81 138 272 0.0564 8.94 4.344 0.6275 27717.6
13300000
8080000000
5720000000000
0.4886 0.1747 0.0110 0.0020 0.0386 0.0109 0.0684 0.0288 0.1323 0.0387 0.2183 0.1107 0.1940 0.1846 0.1147 0.1166 0.1422 0.1509 0.0805 0.3568 0.0009 0.0007 0.0031 0.0037 0.0037 0.0072 0.0119 0.0120 0.0417 0.0400 0.0716 0.0744 0.0409 0.0423 0.0707 0.0596 0.7555 0.7601 0.0008 0.0004 0.0011 0.0022 0.0042 0.0043 0.0168 0.0173 0.0348 0.0381 0.0880 0.0934 0.0513 0.0510 0.0677 0.0636 0.7353 0.7297 0.0007 0.0010 0.0036 0.0116 0.0416 0.0819 0.0459 0.0714 0.7423
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 919 900 image if available 2948 8244 666.3 129.72 46.17 98.68 485 545 590 628 667 705 744 787 840 0.0761 627 1.113 69.64 24.02 1 0.0580 171 0.0007 51.40 7.349 0.1601 460748.0
329000000
243000000000
184000000000000
0.3935 0.2423 0.0000 0.0000 0.0016 0.0000 0.0016 0.0000 0.0110 0.0014 0.0460 0.0183 0.0826 0.0341 0.0727 0.0251 0.1130 0.0389 0.6715 0.8822 0.0000 0.0000 0.0004 0.0000 0.0000 0.0000 0.0041 0.0007 0.0202 0.0156 0.0326 0.0302 0.0223 0.0156 0.0396 0.0282 0.8808 0.9097 0.0019 0.0000 0.0039 0.0476 0.0273 0.0476 0.0253 0.1905 0.0916 0.2857 0.1443 0.1190 0.1033 0.2381 0.1618 0.0714 0.4405 0.0000 0.0007 0.0007 0.0027 0.0115 0.0392 0.0635 0.0581 0.0878 0.7360 9 11 12 14 16 21 28 43 87 0.1378 4.69 3.060 0.7458 11867.4
6550000
4590000000
3630000000000
0.6519 0.0809 0.0058 0.0114 0.0378 0.0178 0.0683 0.0242 0.1541 0.0604 0.1788 0.0768 0.1788 0.1230 0.1541 0.1393 0.1424 0.1628 0.0799 0.3845 0.0010 0.0064 0.0066 0.0092 0.0082 0.0104 0.0255 0.0249 0.0541 0.0385 0.0745 0.0686 0.0760 0.0735 0.1102 0.0951 0.6439 0.6732 0.0008 0.0018 0.0063 0.0055 0.0181 0.0101 0.0291 0.0194 0.0708 0.0738 0.0904 0.1042 0.0818 0.0821 0.1344 0.1245 0.5684 0.5784 0.0032 0.0051 0.0154 0.0199 0.0656 0.0836 0.0855 0.1215 0.6000
BT-20
0
DRAQ5 1 TMRE 2 2 2 1 866 124 image if available 7868 18298 509.3 103.27 71.24 63.85 380 418 450 475 502 530 561 596 645 0.0624 1141 1.024 98.60 36.00 1 0.0336 264 0.0007 43.87 7.460 0.1703 270039.0
149000000
85000000000
50300000000000
0.4294 0.2140 0.0004 0.0000 0.0011 0.0001 0.0029 0.0005 0.0116 0.0009 0.0506 0.0141 0.0958 0.0303 0.1076 0.0255 0.1326 0.0412 0.5975 0.8874 0.0000 0.0000 0.0005 0.0000 0.0014 0.0001 0.0044 0.0005 0.0218 0.0097 0.0421 0.0212 0.0456 0.0141 0.0611 0.0214 0.8231 0.9329 0.0015 0.0151 0.0115 0.0075 0.0137 0.0491 0.0634 0.0943 0.0977 0.1698 0.1504 0.1698 0.1107 0.1132 0.1427 0.1208 0.4084 0.2604 0.0005 0.0021 0.0061 0.0192 0.0541 0.0908 0.0842 0.1111 0.6320 12 20 32 44 56 67 82 103 155 0.0160 5.43 4.946 0.5259 9151.3
1720000
410000000
113000000000
0.3977 0.2161 0.0063 0.0014 0.0287 0.0034 0.0848 0.0127 0.1175 0.0402 0.1734 0.0962 0.1759 0.1181 0.1582 0.1348 0.1455 0.1664 0.1097 0.4269 0.0011 0.0006 0.0036 0.0013 0.0059 0.0046 0.0190 0.0127 0.0462 0.0332 0.0641 0.0471 0.0697 0.0516 0.0984 0.0760 0.6920 0.7730 0.0018 0.0028 0.0049 0.0062 0.0101 0.0130 0.0352 0.0370 0.0677 0.0795 0.0948 0.0956 0.0883 0.0857 0.1176 0.1134 0.5795 0.5667 0.0029 0.0063 0.0092 0.0245 0.0550 0.0789 0.0782 0.1114 0.6337
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 353 558 image if available 3264 13261 567.7 97.23 20.25 30.53 423 480 524 555 578 601 624 651 686 0.0525 696 0.829 83.26 24.17 2 0.0757 247 0.0012 24.55 6.947 0.2311 331741.0
199000000
122000000000
75900000000000
0.3761 0.2603 0.0000 0.0000 0.0000 0.0000 0.0013 0.0000 0.0042 0.0015 0.0348 0.0117 0.0809 0.0329 0.0637 0.0151 0.0926 0.0194 0.7227 0.9195 0.0000 0.0000 0.0000 0.0000 0.0007 0.0000 0.0018 0.0012 0.0138 0.0117 0.0348 0.0322 0.0210 0.0129 0.0246 0.0169 0.9033 0.9251 0.0000 0.0000 0.0134 0.0000 0.0267 0.0000 0.0829 0.2000 0.1337 0.2000 0.2086 0.2000 0.1310 0.2000 0.1230 0.2000 0.2807 0.0000 0.0000 0.0011 0.0022 0.0117 0.0458 0.1011 0.0844 0.1000 0.6536 6 8 9 10 11 13 15 19 43 0.3560 0.58 1.966 0.8565 1342.4
217327
52700000
15600000000
0.5872 0.1138 0.0827 0.0402 0.0911 0.0460 0.0905 0.0583 0.1079 0.0708 0.1235 0.1009 0.1307 0.1071 0.1589 0.1225 0.1457 0.1493 0.0689 0.3048 0.0327 0.0279 0.0346 0.0300 0.0335 0.0375 0.0372 0.0451 0.0380 0.0643 0.0515 0.0758 0.0560 0.0781 0.0861 0.0967 0.6304 0.5445 0.0142 0.0053 0.0137 0.0053 0.0132 0.0107 0.0179 0.0165 0.0189 0.0256 0.0344 0.0373 0.0387 0.0453 0.0783 0.0719 0.7708 0.7821 0.0197 0.0239 0.0239 0.0337 0.0322 0.0405 0.0348 0.0594 0.7319
MDA-MB-231 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 248 500 image if available 1039 2688 496.1 98.73 39.06 62.95 376 424 458 485 504 521 536 562 631 0.1365 367 0.740 130.00 22.83 1 0.2849 296 0.0017 65.54 6.527 0.1617 255811.0
136000000
73900000000
41200000000000
0.4036 0.2366 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0054 0.0020 0.0499 0.0318 0.0823 0.0417 0.0702 0.0328 0.0931 0.0557 0.6991 0.8360 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0011 0.0020 0.0324 0.0307 0.0525 0.0396 0.0357 0.0277 0.0558 0.0455 0.8225 0.8546 0.0000 0.0000 0.0000 0.2000 0.0065 0.6000 0.0258 0.2000 0.0710 0.0000 0.0903 0.0000 0.0645 0.0000 0.1032 0.0000 0.6387 0.0000 0.0000 0.0017 0.0017 0.0174 0.0522 0.0922 0.0783 0.0939 0.6626 7 8 10 13 15 18 23 43 112 0.1239 2.12 3.167 0.7441 5486.9
1350000
417000000
146000000000
0.5373 0.1116 0.0154 0.0541 0.0538 0.0510 0.0846 0.0318 0.1231 0.0701 0.1231 0.0987 0.2077 0.0955 0.1462 0.1178 0.1538 0.2102 0.0923 0.2707 0.0031 0.0211 0.0108 0.0199 0.0093 0.0112 0.0170 0.0211 0.0216 0.0373 0.0386 0.0398 0.0448 0.0460 0.0802 0.1007 0.7747 0.7027 0.0039 0.0020 0.0039 0.0000 0.0019 0.0041 0.0135 0.0122 0.0251 0.0245 0.0290 0.0306 0.0444 0.0510 0.0734 0.0592 0.8050 0.8163 0.0070 0.0053 0.0088 0.0140 0.0298 0.0385 0.0403 0.0788 0.7776
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 580 433 image if available 1493 7000 280.3 39.92 26.94 45.70 230 246 259 269 278 289 298 312 333 0.0730 511 0.722 72.57 16.03 1 0.1092 163 0.0044 8.62 5.687 0.3499 80150.8
23400000
6950000000
2110000000000
0.4223 0.2148 0.0000 0.0000 0.0008 0.0000 0.0000 0.0000 0.0064 0.0007 0.0385 0.0235 0.0577 0.0450 0.0513 0.0215 0.0810 0.0403 0.7642 0.8690 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0036 0.0007 0.0246 0.0221 0.0377 0.0442 0.0261 0.0181 0.0399 0.0328 0.8681 0.8821 0.0226 0.2000 0.0150 0.2000 0.0526 0.4000 0.0677 0.2000 0.0602 0.0000 0.1053 0.0000 0.0902 0.0000 0.1278 0.0000 0.4586 0.0000 0.0014 0.0014 0.0069 0.0220 0.0495 0.0755 0.0975 0.1319 0.6140 7 8 9 10 12 15 20 33 57 0.2933 1.67 2.358 0.8342 2814.2
777978
343000000
188000000000
0.6091 0.1098 0.0437 0.0353 0.0542 0.0453 0.0822 0.0637 0.1014 0.0599 0.1294 0.0860 0.1451 0.1083 0.1521 0.1045 0.1573 0.1421 0.1346 0.3548 0.0065 0.0172 0.0101 0.0192 0.0081 0.0204 0.0141 0.0188 0.0252 0.0337 0.0348 0.0425 0.0403 0.0357 0.0685 0.0665 0.7924 0.7459 0.0035 0.0050 0.0042 0.0084 0.0099 0.0168 0.0156 0.0218 0.0453 0.0536 0.0545 0.0662 0.0630 0.0679 0.1288 0.1274 0.6752 0.6329 0.0024 0.0047 0.0082 0.0141 0.0294 0.0500 0.0488 0.1106 0.7318
BT-20 A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 765 448 image if available 1036 4704 600.2 210.48 6.20 1.84 332 391 444 509 577 659 743 818 904 0.0897 422 1.225 53.31 21.95 1 0.1332 138 0.0016 24.08 6.554 0.2404 404516.0
298000000
234000000000
192000000000000
0.3419 0.2894 0.0000 0.0000 0.0000 0.0000 0.0000 0.0014 0.0031 0.0043 0.1242 0.0558 0.2329 0.1016 0.1304 0.0629 0.1739 0.0801 0.3354 0.6938 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0011 0.0392 0.0339 0.0633 0.0532 0.0271 0.0271 0.0542 0.0407 0.8163 0.8439 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0058 0.0324 0.0585 0.0649 0.0848 0.1135 0.0409 0.0757 0.0673 0.0811 0.7427 0.6324 0.0000 0.0000 0.0021 0.0062 0.0374 0.0811 0.0395 0.0457 0.7879 4 5 5 6 6 7 7 8 8 0.0274 6.20 3.980 0.3875 41.8
302.145
2320.55
18932.6
0.4537 0.1856 0.0023 0.0005 0.0113 0.0013 0.0441 0.0090 0.1027 0.0249 0.1782 0.0542 0.2398 0.1111 0.2262 0.2325 0.1613 0.3262 0.0341 0.2402 0.0000 0.0000 0.0017 0.0005 0.0047 0.0016 0.0231 0.0099 0.0540 0.0309 0.1005 0.0574 0.1816 0.1030 0.3028 0.2870 0.3314 0.5097 0.1740 0.3416 0.2290 0.2805 0.1980 0.1584 0.1530 0.1041 0.1140 0.0679 0.0770 0.0181 0.0260 0.0158 0.0230 0.0090 0.0060 0.0045 0.0029 0.0141 0.0417 0.0959 0.1617 0.2172 0.2159 0.1543 0.0962
Hs 578T A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 992 554 image if available 458 453 58.6 18.24 15.98 3.18 38 42 46 52 56 61 66 72 84 0.4040 183 0.735 110.07 27.07 1 0.6135 281 0.0119 5.25 4.713 0.4351 3769.0
265175
20300000
1680000000
0.3546 0.2594 0.0000 0.0000 0.0199 0.0000 0.0448 0.0000 0.0597 0.0052 0.1294 0.0735 0.2139 0.1417 0.1791 0.0761 0.1343 0.1155 0.2189 0.5879 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0164 0.0046 0.0656 0.0371 0.1049 0.0928 0.0721 0.0278 0.0951 0.0603 0.6459 0.7773 0.0096 0.0000 0.0000 0.0000 0.0096 0.0600 0.0673 0.1800 0.2019 0.1000 0.1731 0.2800 0.0865 0.1400 0.1635 0.0600 0.2885 0.1800 0.0000 0.0000 0.0048 0.0335 0.1435 0.1483 0.1100 0.1627 0.3971 12 13 14 15 16 17 17 18 20 0.8738 0.06 0.306 0.9702 265.5
4574.87
81636.7
1510000
0.5349 0.1049 0.0031 0.0000 0.0217 0.0000 0.0683 0.0046 0.1211 0.0207 0.2050 0.1359 0.1739 0.1544 0.1739 0.1613 0.1801 0.1521 0.0528 0.3710 0.0026 0.0000 0.0078 0.0000 0.0284 0.0045 0.0413 0.0089 0.1835 0.1250 0.1550 0.1473 0.1576 0.1518 0.1938 0.1384 0.2300 0.4241 0.2923 0.5000 0.1846 0.2143 0.1385 0.2143 0.1846 0.0714 0.1077 0.0000 0.0615 0.0000 0.0308 0.0000 0.0000 0.0000 0.0000 0.0000 0.0195 0.0586 0.1328 0.1445 0.1758 0.1680 0.1367 0.1055 0.0586
MCF 10A A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 797 276 image if available 3081 14857 257.1 73.60 95.99 124.19 175 187 202 218 241 266 296 325 367 0.0703 1045 0.709 60.54 16.03 2 0.0568 175 0.0097 3.01 5.047 0.5308 71538.3
21500000
6880000000
2330000000000
0.3683 0.2682 0.0023 0.0000 0.0053 0.0000 0.0107 0.0015 0.0328 0.0041 0.0710 0.0354 0.1154 0.0479 0.1054 0.0420 0.1398 0.0593 0.5172 0.8099 0.0014 0.0000 0.0019 0.0000 0.0043 0.0007 0.0125 0.0013 0.0288 0.0202 0.0389 0.0276 0.0408 0.0189 0.0504 0.0315 0.8209 0.8998 0.0013 0.0000 0.0000 0.0111 0.0090 0.0028 0.0168 0.0306 0.0530 0.0889 0.0917 0.1306 0.0646 0.1139 0.0904 0.1500 0.6731 0.4722 0.0015 0.0015 0.0052 0.0126 0.0238 0.0535 0.0416 0.0558 0.8045 12 19 29 42 54 70 95 135 230 0.0663 4.54 3.869 0.7237 24635.6
11400000
7270000000
5520000000000
0.4425 0.1810 0.0092 0.0039 0.0252 0.0102 0.0406 0.0158 0.0729 0.0304 0.1237 0.0621 0.1566 0.0900 0.1494 0.0954 0.1869 0.1280 0.2356 0.5641 0.0025 0.0017 0.0033 0.0049 0.0040 0.0052 0.0113 0.0100 0.0302 0.0240 0.0458 0.0344 0.0473 0.0408 0.0691 0.0611 0.7864 0.8179 0.0008 0.0007 0.0034 0.0027 0.0059 0.0050 0.0163 0.0174 0.0487 0.0557 0.0704 0.0795 0.0637 0.0651 0.0789 0.0849 0.7118 0.6890 0.0011 0.0052 0.0059 0.0142 0.0363 0.0542 0.0582 0.0716 0.7533
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 886 459 image if available 3618 10342 579.4 120.00 16.41 14.61 402 502 541 570 596 621 644 667 707 0.0617 638 0.872 72.47 21.02 4 0.0506 183 0.0010 57.19 7.152 0.1994 350122.0
218000000
140000000000
91900000000000
0.4429 0.2126 0.0004 0.0000 0.0000 0.0003 0.0008 0.0006 0.0086 0.0012 0.0409 0.0173 0.0601 0.0352 0.0530 0.0212 0.0823 0.0391 0.7539 0.8852 0.0000 0.0000 0.0000 0.0003 0.0000 0.0006 0.0013 0.0009 0.0167 0.0167 0.0279 0.0301 0.0196 0.0140 0.0382 0.0289 0.8963 0.9084 0.0088 0.0000 0.0044 0.0980 0.0199 0.0000 0.0508 0.0980 0.1258 0.1569 0.1523 0.1765 0.1192 0.0588 0.1501 0.1373 0.3687 0.2745 0.0000 0.0005 0.0063 0.0146 0.0466 0.0777 0.0670 0.0869 0.7005 6 8 9 11 13 15 17 20 29 0.2798 0.41 1.932 0.8610 482.7
28156.6
2820000
388000000
0.4309 0.2072 0.0435 0.0205 0.0470 0.0372 0.0509 0.0455 0.0895 0.0516 0.1126 0.0612 0.1545 0.0846 0.2073 0.1008 0.1905 0.1706 0.1043 0.4280 0.0225 0.0151 0.0206 0.0257 0.0213 0.0301 0.0324 0.0319 0.0506 0.0421 0.0689 0.0635 0.0845 0.0648 0.1386 0.1026 0.5606 0.6242 0.0382 0.0267 0.0326 0.0130 0.0336 0.0298 0.0424 0.0360 0.0559 0.0477 0.0634 0.0701 0.0662 0.0775 0.1058 0.0967 0.5620 0.6026 0.0209 0.0300 0.0386 0.0551 0.0695 0.0973 0.0921 0.1086 0.4879
MDA-MB-231 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 365 353 image if available 5969 9686 532.6 131.58 28.76 57.02 329 402 483 536 572 597 619 644 676 0.0840 814 1.039 109.33 39.70 3 0.0476 284 0.0007 61.44 7.562 0.1890 300963.0
177000000
107000000000
65900000000000
0.4153 0.2188 0.0006 0.0000 0.0018 0.0000 0.0036 0.0002 0.0109 0.0011 0.0555 0.0200 0.0772 0.0344 0.0832 0.0215 0.1212 0.0340 0.6460 0.8888 0.0000 0.0000 0.0000 0.0000 0.0002 0.0002 0.0015 0.0011 0.0246 0.0200 0.0316 0.0336 0.0250 0.0204 0.0396 0.0310 0.8774 0.8937 0.0055 0.0000 0.0071 0.0000 0.0188 1.0000 0.0290 0.0000 0.0565 0.0000 0.0863 0.0000 0.0847 0.0000 0.1145 0.0000 0.5976 0.0000 0.0003 0.0000 0.0019 0.0047 0.0314 0.0394 0.0411 0.0607 0.8205 8 10 11 13 16 21 27 36 51 0.1769 0.75 1.769 0.6861 4078.2
2130000
1520000000
1200000000000
0.5279 0.1420 0.0341 0.0214 0.0384 0.0239 0.0803 0.0306 0.0852 0.0415 0.1165 0.0580 0.1541 0.0685 0.1925 0.0928 0.1996 0.1557 0.0994 0.5076 0.0086 0.0112 0.0106 0.0098 0.0185 0.0121 0.0222 0.0179 0.0376 0.0331 0.0539 0.0414 0.0587 0.0485 0.0952 0.0713 0.6946 0.7548 0.0124 0.0117 0.0133 0.0123 0.0143 0.0178 0.0219 0.0270 0.0505 0.0596 0.0657 0.0713 0.0634 0.0774 0.0991 0.1167 0.6594 0.6063 0.0141 0.0137 0.0213 0.0260 0.0416 0.0513 0.0604 0.0853 0.6863