High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 684 | 361 | | 399 | 6206 | 58.4 | 9.74 | 24.73 | 66.86 | 46 | 49 | 52 | 54 | 57 | 61 | 64 | 69 | 72 | 0.1017 | 631 | 0.682 | 36.24 | 8.54 | 1 | 0.2607 | 104 | 0.0248 | 2.23 | 3.908 | 0.5277 | 3503.6 | 215851 | 13600000 | 881000000 | 0.3536 | 0.2676 | 0.0000 | 0.0000 | 0.0035 | 0.0000 | 0.0071 | 0.0000 | 0.0426 | 0.0101 | 0.0922 | 0.0628 | 0.1525 | 0.0678 | 0.1489 | 0.0653 | 0.1915 | 0.0879 | 0.3617 | 0.7060 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0028 | 0.0000 | 0.0225 | 0.0100 | 0.0535 | 0.0627 | 0.0817 | 0.0677 | 0.0789 | 0.0652 | 0.1042 | 0.0677 | 0.6563 | 0.7268 | 0.0137 | 1.0000 | 0.0000 | 0.0000 | 0.0274 | 0.0000 | 0.0822 | 0.0000 | 0.0822 | 0.0000 | 0.1781 | 0.0000 | 0.1370 | 0.0000 | 0.2055 | 0.0000 | 0.2740 | 0.0000 | 0.0053 | 0.0053 | 0.0159 | 0.0265 | 0.0635 | 0.1111 | 0.1058 | 0.0899 | 0.5767 | 5 | 6 | 7 | 8 | 9 | 10 | 13 | 18 | 40 | 0.3348 | 9.79 | 2.064 | 0.7707 | 5081.6 | 2730000 | 1940000000 | 1570000000000 | 0.6341 | 0.0846 | 0.0349 | 0.0330 | 0.1163 | 0.0366 | 0.1453 | 0.0425 | 0.1628 | 0.0837 | 0.2006 | 0.1262 | 0.1919 | 0.1498 | 0.1163 | 0.1462 | 0.0233 | 0.1686 | 0.0087 | 0.2134 | 0.0053 | 0.0181 | 0.0079 | 0.0194 | 0.0184 | 0.0148 | 0.0202 | 0.0258 | 0.0746 | 0.0523 | 0.0886 | 0.0690 | 0.0912 | 0.0800 | 0.1202 | 0.1052 | 0.5737 | 0.6155 | 0.0025 | 0.0028 | 0.0013 | 0.0000 | 0.0088 | 0.0043 | 0.0251 | 0.0256 | 0.0842 | 0.0954 | 0.1256 | 0.1439 | 0.0942 | 0.1068 | 0.1344 | 0.1296 | 0.5239 | 0.4915 | 0.0022 | 0.0098 | 0.0065 | 0.0271 | 0.0869 | 0.0912 | 0.0988 | 0.1325 | 0.5451 |
| BT-20 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 659 | 864 | | 9157 | 12600 | 572.9 | 114.09 | 133.84 | 114.82 | 435 | 475 | 505 | 534 | 563 | 594 | 628 | 666 | 723 | 0.0900 | 1134 | 1.199 | 96.51 | 40.61 | 1 | 0.0284 | 260 | 0.0005 | 84.01 | 7.780 | 0.1396 | 341248.0 | 211000000 | 136000000000 | 90100000000000 | 0.4173 | 0.2328 | 0.0000 | 0.0000 | 0.0008 | 0.0000 | 0.0013 | 0.0001 | 0.0084 | 0.0014 | 0.0529 | 0.0133 | 0.1231 | 0.0303 | 0.1329 | 0.0280 | 0.1634 | 0.0394 | 0.5172 | 0.8876 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0006 | 0.0000 | 0.0045 | 0.0001 | 0.0267 | 0.0098 | 0.0603 | 0.0210 | 0.0668 | 0.0155 | 0.0864 | 0.0211 | 0.7545 | 0.9324 | 0.0022 | 0.0060 | 0.0129 | 0.0121 | 0.0237 | 0.0423 | 0.0760 | 0.0755 | 0.1097 | 0.1631 | 0.1627 | 0.1450 | 0.0968 | 0.1329 | 0.1168 | 0.1541 | 0.3993 | 0.2689 | 0.0000 | 0.0012 | 0.0046 | 0.0244 | 0.0835 | 0.1249 | 0.1047 | 0.1165 | 0.5403 | 14 | 26 | 50 | 78 | 106 | 138 | 176 | 224 | 297 | 0.0077 | 28.76 | 6.275 | 0.3483 | 31096.2 | 9370000 | 3320000000 | 1310000000000 | 0.6019 | 0.1025 | 0.0320 | 0.0017 | 0.1338 | 0.0087 | 0.2500 | 0.0546 | 0.1658 | 0.1008 | 0.1684 | 0.1801 | 0.1271 | 0.1957 | 0.0646 | 0.1465 | 0.0413 | 0.1349 | 0.0170 | 0.1769 | 0.0005 | 0.0004 | 0.0008 | 0.0005 | 0.0031 | 0.0019 | 0.0161 | 0.0096 | 0.0663 | 0.0503 | 0.1259 | 0.0945 | 0.0830 | 0.0727 | 0.1216 | 0.1056 | 0.5828 | 0.6645 | 0.0009 | 0.0012 | 0.0042 | 0.0084 | 0.0093 | 0.0160 | 0.0313 | 0.0389 | 0.1011 | 0.1062 | 0.1497 | 0.1596 | 0.1025 | 0.1120 | 0.1383 | 0.1416 | 0.4626 | 0.4161 | 0.0008 | 0.0029 | 0.0060 | 0.0229 | 0.0836 | 0.1434 | 0.0928 | 0.1261 | 0.5216 | ||
| MCF 10A | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 307 | 653 | | 10385 | 21337 | 574.1 | 114.46 | 155.18 | 135.73 | 433 | 473 | 505 | 535 | 564 | 596 | 628 | 670 | 733 | 0.0486 | 1036 | 0.577 | 103.02 | 13.04 | 1 | 0.0206 | 214 | 0.0007 | 50.52 | 7.494 | 0.1652 | 342696.0 | 212000000 | 136000000000 | 90600000000000 | 0.4477 | 0.1993 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0020 | 0.0000 | 0.0114 | 0.0003 | 0.0529 | 0.0143 | 0.1183 | 0.0275 | 0.1255 | 0.0275 | 0.1535 | 0.0489 | 0.5362 | 0.8814 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0013 | 0.0000 | 0.0053 | 0.0001 | 0.0241 | 0.0099 | 0.0493 | 0.0168 | 0.0533 | 0.0122 | 0.0720 | 0.0203 | 0.7946 | 0.9407 | 0.0023 | 0.0176 | 0.0082 | 0.0265 | 0.0164 | 0.0676 | 0.0614 | 0.1088 | 0.1392 | 0.2118 | 0.1766 | 0.2000 | 0.1094 | 0.1294 | 0.1433 | 0.1235 | 0.3433 | 0.1147 | 0.0008 | 0.0010 | 0.0049 | 0.0246 | 0.0722 | 0.1181 | 0.0958 | 0.1311 | 0.5515 | 25 | 42 | 64 | 88 | 118 | 150 | 191 | 249 | 337 | 0.0077 | 23.32 | 5.939 | 0.3643 | 42503.4 | 16400000 | 8080000000 | 4790000000000 | 0.5282 | 0.1429 | 0.0347 | 0.0014 | 0.1391 | 0.0079 | 0.2389 | 0.0792 | 0.1810 | 0.1231 | 0.1607 | 0.1736 | 0.1170 | 0.1882 | 0.0714 | 0.1466 | 0.0353 | 0.1335 | 0.0219 | 0.1463 | 0.0005 | 0.0002 | 0.0011 | 0.0004 | 0.0042 | 0.0024 | 0.0233 | 0.0140 | 0.0793 | 0.0638 | 0.1263 | 0.0985 | 0.1017 | 0.0802 | 0.1398 | 0.1307 | 0.5240 | 0.6098 | 0.0009 | 0.0039 | 0.0053 | 0.0039 | 0.0117 | 0.0141 | 0.0449 | 0.0589 | 0.1098 | 0.1287 | 0.1665 | 0.1769 | 0.1228 | 0.1268 | 0.1550 | 0.1577 | 0.3832 | 0.3291 | 0.0010 | 0.0024 | 0.0071 | 0.0342 | 0.0973 | 0.1484 | 0.1159 | 0.1555 | 0.4382 |
| BT-20 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 213 | 896 | | 3746 | 14440 | 324.0 | 67.68 | 163.52 | 174.35 | 235 | 267 | 288 | 305 | 322 | 340 | 359 | 382 | 414 | 0.0614 | 886 | 1.026 | 90.35 | 31.58 | 1 | 0.0670 | 251 | 0.0007 | 89.85 | 7.502 | 0.1378 | 109544.0 | 38500000 | 14000000000 | 5270000000000 | 0.4313 | 0.2081 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0025 | 0.0008 | 0.0143 | 0.0014 | 0.0573 | 0.0161 | 0.1297 | 0.0417 | 0.1481 | 0.0296 | 0.1661 | 0.0735 | 0.4822 | 0.8369 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0006 | 0.0005 | 0.0052 | 0.0014 | 0.0223 | 0.0128 | 0.0419 | 0.0312 | 0.0461 | 0.0115 | 0.0652 | 0.0325 | 0.8187 | 0.9101 | 0.0015 | 0.0741 | 0.0092 | 0.0556 | 0.0382 | 0.0926 | 0.0947 | 0.1667 | 0.1740 | 0.1852 | 0.1969 | 0.1481 | 0.1191 | 0.0926 | 0.1481 | 0.1111 | 0.2183 | 0.0741 | 0.0000 | 0.0005 | 0.0054 | 0.0264 | 0.0696 | 0.1192 | 0.1154 | 0.1472 | 0.5162 | 13 | 17 | 27 | 55 | 99 | 150 | 212 | 304 | 427 | 0.0207 | 22.64 | 5.797 | 0.4177 | 57133.8 | 26400000 | 14400000000 | 8750000000000 | 0.5240 | 0.1275 | 0.0365 | 0.0012 | 0.1204 | 0.0053 | 0.1762 | 0.0439 | 0.2018 | 0.1082 | 0.1883 | 0.1766 | 0.1249 | 0.1778 | 0.0762 | 0.1466 | 0.0532 | 0.1487 | 0.0224 | 0.1917 | 0.0006 | 0.0004 | 0.0018 | 0.0006 | 0.0042 | 0.0024 | 0.0165 | 0.0138 | 0.0564 | 0.0447 | 0.0762 | 0.0656 | 0.0665 | 0.0531 | 0.0911 | 0.0798 | 0.6869 | 0.7397 | 0.0013 | 0.0013 | 0.0019 | 0.0043 | 0.0055 | 0.0080 | 0.0249 | 0.0268 | 0.0675 | 0.0771 | 0.0949 | 0.1009 | 0.0777 | 0.0746 | 0.0971 | 0.0949 | 0.6292 | 0.6123 | 0.0004 | 0.0022 | 0.0050 | 0.0187 | 0.0604 | 0.0872 | 0.0731 | 0.1006 | 0.6523 |
| MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 293 | 609 | | 8337 | 19608 | 101.9 | 24.16 | 175.88 | 142.47 | 73 | 81 | 88 | 94 | 100 | 105 | 112 | 120 | 133 | 0.0523 | 1025 | 1.074 | 109.56 | 38.12 | 1 | 0.0356 | 297 | 0.0033 | 13.03 | 6.018 | 0.3011 | 10963.8 | 1250000 | 150000000 | 19200000000 | 0.4490 | 0.2070 | 0.0004 | 0.0001 | 0.0023 | 0.0001 | 0.0097 | 0.0004 | 0.0284 | 0.0036 | 0.0817 | 0.0181 | 0.1470 | 0.0410 | 0.1702 | 0.0513 | 0.1762 | 0.0783 | 0.3842 | 0.8070 | 0.0000 | 0.0000 | 0.0006 | 0.0000 | 0.0032 | 0.0002 | 0.0086 | 0.0011 | 0.0365 | 0.0115 | 0.0679 | 0.0245 | 0.0709 | 0.0208 | 0.1034 | 0.0398 | 0.7091 | 0.9020 | 0.0034 | 0.0064 | 0.0135 | 0.0451 | 0.0310 | 0.0579 | 0.1018 | 0.1373 | 0.1415 | 0.1803 | 0.1894 | 0.1717 | 0.1240 | 0.0880 | 0.1388 | 0.1652 | 0.2567 | 0.1481 | 0.0010 | 0.0026 | 0.0126 | 0.0419 | 0.0856 | 0.1309 | 0.1186 | 0.1404 | 0.4663 | 19 | 44 | 74 | 106 | 143 | 186 | 235 | 291 | 376 | 0.0029 | 66.47 | 7.155 | 0.2685 | 51228.7 | 19100000 | 8380000000 | 4150000000000 | 0.4441 | 0.1782 | 0.0134 | 0.0030 | 0.0694 | 0.0074 | 0.1927 | 0.0268 | 0.1717 | 0.0701 | 0.1818 | 0.1554 | 0.1490 | 0.1966 | 0.0920 | 0.1467 | 0.0742 | 0.1533 | 0.0557 | 0.2406 | 0.0008 | 0.0005 | 0.0013 | 0.0013 | 0.0030 | 0.0031 | 0.0128 | 0.0102 | 0.0442 | 0.0384 | 0.0810 | 0.0621 | 0.0713 | 0.0562 | 0.1002 | 0.0808 | 0.6853 | 0.7475 | 0.0015 | 0.0011 | 0.0021 | 0.0051 | 0.0067 | 0.0130 | 0.0204 | 0.0276 | 0.0725 | 0.0848 | 0.1212 | 0.1448 | 0.1025 | 0.1133 | 0.1303 | 0.1466 | 0.5429 | 0.4637 | 0.0005 | 0.0020 | 0.0054 | 0.0154 | 0.0553 | 0.1015 | 0.0850 | 0.1150 | 0.6199 | ||
| MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 1246 | 581 | | 5724 | 10893 | 64.5 | 15.39 | 236.73 | 211.09 | 47 | 52 | 56 | 60 | 63 | 66 | 70 | 75 | 83 | 0.1007 | 1097 | 0.634 | 184.57 | 34.06 | 2 | 0.0786 | 450 | 0.0087 | 5.31 | 5.104 | 0.4181 | 4403.3 | 318930 | 24700000 | 2070000000 | 0.5293 | 0.1575 | 0.0011 | 0.0000 | 0.0029 | 0.0002 | 0.0149 | 0.0025 | 0.0344 | 0.0079 | 0.0831 | 0.0249 | 0.1403 | 0.0624 | 0.1470 | 0.0543 | 0.2027 | 0.0933 | 0.3736 | 0.7545 | 0.0002 | 0.0000 | 0.0006 | 0.0000 | 0.0073 | 0.0014 | 0.0168 | 0.0048 | 0.0432 | 0.0173 | 0.0852 | 0.0464 | 0.0787 | 0.0324 | 0.1224 | 0.0582 | 0.6454 | 0.8396 | 0.0146 | 0.0251 | 0.0258 | 0.0282 | 0.0538 | 0.0219 | 0.0806 | 0.1066 | 0.1333 | 0.1818 | 0.1445 | 0.1630 | 0.1333 | 0.1348 | 0.1344 | 0.1285 | 0.2800 | 0.2100 | 0.0049 | 0.0125 | 0.0245 | 0.0623 | 0.1061 | 0.1303 | 0.1318 | 0.1477 | 0.3799 | 16 | 25 | 64 | 130 | 196 | 261 | 329 | 412 | 529 | 0.0116 | 86.41 | 6.934 | 0.2713 | 100595.0 | 54000000 | 33700000000 | 23600000000000 | 0.4576 | 0.1893 | 0.0320 | 0.0013 | 0.1436 | 0.0119 | 0.2339 | 0.0569 | 0.1831 | 0.1264 | 0.1737 | 0.1747 | 0.1260 | 0.2062 | 0.0652 | 0.1467 | 0.0332 | 0.1364 | 0.0094 | 0.1396 | 0.0005 | 0.0003 | 0.0027 | 0.0008 | 0.0034 | 0.0019 | 0.0151 | 0.0095 | 0.0589 | 0.0467 | 0.0943 | 0.0811 | 0.0861 | 0.0713 | 0.1289 | 0.1061 | 0.6100 | 0.6824 | 0.0003 | 0.0012 | 0.0025 | 0.0031 | 0.0076 | 0.0127 | 0.0227 | 0.0347 | 0.0882 | 0.1018 | 0.1372 | 0.1535 | 0.1175 | 0.1148 | 0.1447 | 0.1528 | 0.4794 | 0.4254 | 0.0017 | 0.0015 | 0.0040 | 0.0185 | 0.0733 | 0.1092 | 0.0968 | 0.1432 | 0.5521 |
| MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1002 | 903 | | 2590 | 6854 | 671.8 | 130.82 | 57.85 | 118.91 | 504 | 556 | 597 | 632 | 666 | 700 | 730 | 773 | 852 | 0.0926 | 635 | 0.749 | 181.18 | 45.31 | 2 | 0.1853 | 480 | 0.0008 | 66.05 | 7.317 | 0.1448 | 468423.0 | 339000000 | 253000000000 | 195000000000000 | 0.4212 | 0.2260 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0006 | 0.0004 | 0.0062 | 0.0020 | 0.0506 | 0.0208 | 0.1069 | 0.0425 | 0.0771 | 0.0261 | 0.1187 | 0.0357 | 0.6398 | 0.8725 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0004 | 0.0032 | 0.0008 | 0.0272 | 0.0159 | 0.0614 | 0.0348 | 0.0378 | 0.0147 | 0.0591 | 0.0224 | 0.8113 | 0.9111 | 0.0051 | 0.0000 | 0.0000 | 0.0000 | 0.0103 | 0.0220 | 0.0282 | 0.0879 | 0.0872 | 0.1209 | 0.1385 | 0.1758 | 0.0923 | 0.1868 | 0.1256 | 0.1538 | 0.5128 | 0.2527 | 0.0008 | 0.0000 | 0.0040 | 0.0217 | 0.0593 | 0.1051 | 0.0842 | 0.1043 | 0.6207 | 10 | 12 | 13 | 16 | 22 | 33 | 42 | 64 | 129 | 0.1077 | 12.25 | 3.455 | 0.7303 | 17483.7 | 14800000 | 20400000000 | 35900000000000 | 0.6243 | 0.0943 | 0.0239 | 0.0079 | 0.0613 | 0.0126 | 0.0733 | 0.0238 | 0.1346 | 0.0516 | 0.1891 | 0.0827 | 0.1704 | 0.1263 | 0.1891 | 0.1468 | 0.1193 | 0.1640 | 0.0392 | 0.3843 | 0.0054 | 0.0046 | 0.0113 | 0.0057 | 0.0097 | 0.0092 | 0.0199 | 0.0218 | 0.0485 | 0.0402 | 0.0889 | 0.0766 | 0.0711 | 0.0808 | 0.0867 | 0.0938 | 0.6584 | 0.6673 | 0.0039 | 0.0018 | 0.0024 | 0.0027 | 0.0087 | 0.0064 | 0.0221 | 0.0282 | 0.0559 | 0.0645 | 0.1087 | 0.1064 | 0.0693 | 0.0709 | 0.0969 | 0.0982 | 0.6320 | 0.6209 | 0.0026 | 0.0066 | 0.0066 | 0.0178 | 0.0540 | 0.0949 | 0.0639 | 0.0988 | 0.6548 |
| MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 216 | 528 | | 5345 | 6687 | 126.2 | 29.45 | 246.37 | 196.30 | 92 | 102 | 109 | 116 | 122 | 129 | 137 | 148 | 166 | 0.1069 | 715 | 0.821 | 98.35 | 24.08 | 1 | 0.0462 | 247 | 0.0025 | 20.42 | 6.327 | 0.2607 | 16786.6 | 2360000 | 350000000 | 54900000000 | 0.4217 | 0.2280 | 0.0006 | 0.0000 | 0.0020 | 0.0002 | 0.0049 | 0.0002 | 0.0260 | 0.0037 | 0.0795 | 0.0242 | 0.1393 | 0.0480 | 0.1549 | 0.0494 | 0.1980 | 0.0730 | 0.3948 | 0.8015 | 0.0002 | 0.0000 | 0.0014 | 0.0002 | 0.0025 | 0.0000 | 0.0114 | 0.0013 | 0.0377 | 0.0144 | 0.0616 | 0.0276 | 0.0705 | 0.0203 | 0.1045 | 0.0325 | 0.7102 | 0.9036 | 0.0065 | 0.0029 | 0.0043 | 0.0324 | 0.0293 | 0.0412 | 0.0759 | 0.1265 | 0.1605 | 0.1765 | 0.1811 | 0.1882 | 0.1215 | 0.1500 | 0.1443 | 0.1412 | 0.2766 | 0.1412 | 0.0037 | 0.0058 | 0.0146 | 0.0379 | 0.0853 | 0.1328 | 0.1087 | 0.1424 | 0.4688 | 29 | 68 | 108 | 156 | 206 | 258 | 323 | 400 | 511 | 0.0020 | 102.03 | 7.263 | 0.2296 | 99223.3 | 51700000 | 32100000000 | 22600000000000 | 0.4373 | 0.2354 | 0.0192 | 0.0026 | 0.0936 | 0.0096 | 0.1554 | 0.0379 | 0.1930 | 0.0889 | 0.1696 | 0.1612 | 0.1637 | 0.1886 | 0.0952 | 0.1468 | 0.0693 | 0.1476 | 0.0409 | 0.2169 | 0.0003 | 0.0010 | 0.0017 | 0.0010 | 0.0063 | 0.0027 | 0.0199 | 0.0129 | 0.0515 | 0.0493 | 0.1085 | 0.0818 | 0.0863 | 0.0592 | 0.1102 | 0.0896 | 0.6153 | 0.7027 | 0.0000 | 0.0000 | 0.0026 | 0.0055 | 0.0110 | 0.0197 | 0.0408 | 0.0466 | 0.0891 | 0.1102 | 0.1414 | 0.1694 | 0.1137 | 0.1190 | 0.1378 | 0.1464 | 0.4636 | 0.3832 | 0.0007 | 0.0028 | 0.0067 | 0.0245 | 0.0823 | 0.1199 | 0.0986 | 0.1341 | 0.5303 |
| MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 921 | 565 | | 4515 | 12772 | 136.3 | 38.62 | 135.27 | 164.66 | 95 | 105 | 113 | 121 | 130 | 139 | 150 | 162 | 185 | 0.0755 | 964 | 1.187 | 118.21 | 44.41 | 1 | 0.0669 | 302 | 0.0020 | 26.20 | 6.545 | 0.2402 | 20065.9 | 3220000 | 568000000 | 111000000000 | 0.4520 | 0.1988 | 0.0008 | 0.0000 | 0.0063 | 0.0002 | 0.0079 | 0.0015 | 0.0359 | 0.0057 | 0.1031 | 0.0269 | 0.1647 | 0.0507 | 0.1686 | 0.0672 | 0.1675 | 0.0961 | 0.3452 | 0.7517 | 0.0006 | 0.0000 | 0.0024 | 0.0000 | 0.0038 | 0.0000 | 0.0148 | 0.0023 | 0.0440 | 0.0169 | 0.0750 | 0.0289 | 0.0735 | 0.0321 | 0.1004 | 0.0456 | 0.6856 | 0.8742 | 0.0058 | 0.0106 | 0.0023 | 0.0079 | 0.0257 | 0.0475 | 0.0690 | 0.1055 | 0.1415 | 0.1583 | 0.1825 | 0.1900 | 0.1158 | 0.1161 | 0.1485 | 0.1451 | 0.3088 | 0.2190 | 0.0010 | 0.0041 | 0.0066 | 0.0259 | 0.0984 | 0.1324 | 0.1014 | 0.1460 | 0.4843 | 15 | 25 | 38 | 52 | 69 | 95 | 139 | 214 | 357 | 0.0059 | 46.41 | 6.387 | 0.3599 | 45409.4 | 23600000 | 15300000000 | 11300000000000 | 0.5555 | 0.1162 | 0.0282 | 0.0014 | 0.1229 | 0.0134 | 0.1832 | 0.0569 | 0.1691 | 0.0999 | 0.1660 | 0.1578 | 0.1644 | 0.1942 | 0.0854 | 0.1469 | 0.0517 | 0.1487 | 0.0290 | 0.1808 | 0.0009 | 0.0005 | 0.0011 | 0.0026 | 0.0036 | 0.0047 | 0.0189 | 0.0160 | 0.0560 | 0.0476 | 0.0910 | 0.0845 | 0.0674 | 0.0653 | 0.0964 | 0.0962 | 0.6647 | 0.6826 | 0.0003 | 0.0003 | 0.0015 | 0.0010 | 0.0050 | 0.0096 | 0.0207 | 0.0244 | 0.0645 | 0.0753 | 0.1112 | 0.1073 | 0.0721 | 0.0815 | 0.1076 | 0.1100 | 0.6171 | 0.5904 | 0.0013 | 0.0013 | 0.0066 | 0.0151 | 0.0602 | 0.0983 | 0.0748 | 0.0985 | 0.6440 | ||
| MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 506 | 842 | | 4164 | 7027 | 174.9 | 56.54 | 178.00 | 147.56 | 112 | 130 | 142 | 152 | 163 | 178 | 195 | 217 | 248 | 0.0992 | 697 | 1.133 | 87.73 | 29.97 | 1 | 0.0531 | 221 | 0.0010 | 60.00 | 7.142 | 0.1752 | 33770.8 | 7210000 | 1700000000 | 440000000000 | 0.4464 | 0.2087 | 0.0005 | 0.0000 | 0.0029 | 0.0000 | 0.0141 | 0.0006 | 0.0522 | 0.0044 | 0.1370 | 0.0397 | 0.1936 | 0.0823 | 0.1921 | 0.0887 | 0.1775 | 0.1264 | 0.2301 | 0.6580 | 0.0003 | 0.0000 | 0.0007 | 0.0000 | 0.0030 | 0.0000 | 0.0116 | 0.0021 | 0.0475 | 0.0234 | 0.0857 | 0.0412 | 0.0834 | 0.0368 | 0.1113 | 0.0577 | 0.6565 | 0.8388 | 0.0031 | 0.0022 | 0.0021 | 0.0153 | 0.0073 | 0.0131 | 0.0636 | 0.1160 | 0.1366 | 0.1751 | 0.1783 | 0.2079 | 0.1220 | 0.1072 | 0.1689 | 0.1379 | 0.3180 | 0.2254 | 0.0011 | 0.0006 | 0.0034 | 0.0311 | 0.0911 | 0.1324 | 0.1046 | 0.1414 | 0.4943 | 27 | 50 | 74 | 106 | 140 | 178 | 225 | 292 | 389 | 0.0022 | 67.53 | 7.034 | 0.2591 | 53457.0 | 21400000 | 10400000000 | 5770000000000 | 0.4709 | 0.1839 | 0.0246 | 0.0021 | 0.1054 | 0.0050 | 0.2141 | 0.0504 | 0.1742 | 0.0881 | 0.1708 | 0.1448 | 0.1351 | 0.1725 | 0.0799 | 0.1469 | 0.0654 | 0.1452 | 0.0306 | 0.2451 | 0.0003 | 0.0007 | 0.0014 | 0.0000 | 0.0041 | 0.0026 | 0.0151 | 0.0086 | 0.0704 | 0.0509 | 0.1194 | 0.0961 | 0.0898 | 0.0692 | 0.1292 | 0.1056 | 0.5703 | 0.6664 | 0.0022 | 0.0022 | 0.0035 | 0.0049 | 0.0101 | 0.0121 | 0.0321 | 0.0351 | 0.0981 | 0.1185 | 0.1438 | 0.1580 | 0.1130 | 0.0971 | 0.1328 | 0.1377 | 0.4644 | 0.4344 | 0.0004 | 0.0028 | 0.0042 | 0.0276 | 0.0850 | 0.1324 | 0.0967 | 0.1328 | 0.5181 | ||
| MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 550 | 347 | | 2625 | 7570 | 364.6 | 100.61 | 57.27 | 93.59 | 229 | 271 | 313 | 338 | 359 | 381 | 405 | 462 | 513 | 0.0856 | 648 | 0.595 | 111.40 | 19.31 | 7 | 0.1051 | 276 | 0.0012 | 33.64 | 6.958 | 0.2138 | 143052.0 | 59700000 | 26200000000 | 12000000000000 | 0.3697 | 0.2506 | 0.0000 | 0.0005 | 0.0000 | 0.0009 | 0.0007 | 0.0023 | 0.0162 | 0.0079 | 0.0855 | 0.0410 | 0.1179 | 0.0843 | 0.0929 | 0.0531 | 0.0899 | 0.0754 | 0.5969 | 0.7346 | 0.0000 | 0.0004 | 0.0000 | 0.0000 | 0.0000 | 0.0008 | 0.0035 | 0.0016 | 0.0333 | 0.0276 | 0.0455 | 0.0470 | 0.0414 | 0.0272 | 0.0510 | 0.0404 | 0.8253 | 0.8549 | 0.0000 | 0.0000 | 0.0000 | 0.0108 | 0.0000 | 0.0216 | 0.0225 | 0.0396 | 0.0722 | 0.1367 | 0.1075 | 0.2086 | 0.0690 | 0.1223 | 0.1043 | 0.1295 | 0.6244 | 0.3309 | 0.0000 | 0.0008 | 0.0048 | 0.0191 | 0.0590 | 0.0901 | 0.0726 | 0.0989 | 0.6547 | 8 | 10 | 12 | 14 | 18 | 23 | 38 | 87 | 161 | 0.1461 | 5.86 | 3.394 | 0.7357 | 12038.0 | 4300000 | 1950000000 | 1010000000000 | 0.6794 | 0.0692 | 0.0238 | 0.0092 | 0.0506 | 0.0184 | 0.1131 | 0.0407 | 0.1310 | 0.0512 | 0.2292 | 0.1168 | 0.2083 | 0.1444 | 0.1280 | 0.1470 | 0.0893 | 0.1745 | 0.0268 | 0.2979 | 0.0019 | 0.0025 | 0.0014 | 0.0038 | 0.0068 | 0.0059 | 0.0106 | 0.0106 | 0.0323 | 0.0317 | 0.0651 | 0.0571 | 0.0458 | 0.0440 | 0.0719 | 0.0693 | 0.7641 | 0.7751 | 0.0006 | 0.0000 | 0.0012 | 0.0006 | 0.0035 | 0.0075 | 0.0098 | 0.0106 | 0.0368 | 0.0399 | 0.0725 | 0.0761 | 0.0478 | 0.0586 | 0.0725 | 0.0773 | 0.7553 | 0.7294 | 0.0005 | 0.0011 | 0.0053 | 0.0090 | 0.0329 | 0.0638 | 0.0515 | 0.0733 | 0.7625 |
| MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 831 | 627 | | 22430 | 35732 | 126.0 | 38.62 | 252.74 | 227.53 | 82 | 95 | 104 | 113 | 121 | 131 | 142 | 157 | 179 | 0.0532 | 1901 | 0.880 | 73.43 | 20.81 | 2 | 0.0089 | 200 | 0.0017 | 21.99 | 6.753 | 0.2609 | 17379.7 | 2600000 | 417000000 | 71800000000 | 0.4412 | 0.2102 | 0.0006 | 0.0001 | 0.0021 | 0.0002 | 0.0088 | 0.0011 | 0.0346 | 0.0052 | 0.1045 | 0.0291 | 0.1823 | 0.0693 | 0.1643 | 0.0693 | 0.1767 | 0.0997 | 0.3261 | 0.7259 | 0.0002 | 0.0001 | 0.0008 | 0.0001 | 0.0022 | 0.0002 | 0.0101 | 0.0018 | 0.0357 | 0.0141 | 0.0709 | 0.0319 | 0.0688 | 0.0258 | 0.0917 | 0.0432 | 0.7197 | 0.8826 | 0.0034 | 0.0054 | 0.0050 | 0.0100 | 0.0140 | 0.0284 | 0.0533 | 0.0888 | 0.0998 | 0.1568 | 0.1659 | 0.2106 | 0.1164 | 0.1172 | 0.1451 | 0.1426 | 0.3972 | 0.2402 | 0.0011 | 0.0034 | 0.0087 | 0.0271 | 0.0720 | 0.1160 | 0.1006 | 0.1196 | 0.5516 | 16 | 33 | 75 | 138 | 204 | 273 | 343 | 432 | 576 | 0.0082 | 55.93 | 6.842 | 0.3237 | 115644.0 | 68100000 | 47400000000 | 37300000000000 | 0.5184 | 0.1555 | 0.0294 | 0.0010 | 0.1132 | 0.0078 | 0.2146 | 0.0613 | 0.1758 | 0.0954 | 0.1640 | 0.1647 | 0.1397 | 0.1993 | 0.0852 | 0.1472 | 0.0476 | 0.1393 | 0.0304 | 0.1840 | 0.0000 | 0.0002 | 0.0006 | 0.0007 | 0.0018 | 0.0015 | 0.0125 | 0.0070 | 0.0472 | 0.0386 | 0.0990 | 0.0797 | 0.0795 | 0.0590 | 0.1063 | 0.0906 | 0.6532 | 0.7227 | 0.0006 | 0.0013 | 0.0027 | 0.0029 | 0.0077 | 0.0109 | 0.0241 | 0.0340 | 0.0806 | 0.1011 | 0.1356 | 0.1539 | 0.1094 | 0.1178 | 0.1359 | 0.1438 | 0.5033 | 0.4344 | 0.0003 | 0.0016 | 0.0049 | 0.0169 | 0.0624 | 0.1189 | 0.0930 | 0.1202 | 0.5819 |
| MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 1101 | 742 | | 4651 | 3841 | 130.8 | 24.62 | 205.76 | 139.04 | 103 | 111 | 116 | 122 | 128 | 133 | 140 | 148 | 161 | 0.1854 | 712 | 1.111 | 92.85 | 30.41 | 1 | 0.0495 | 230 | 0.0036 | 13.07 | 5.941 | 0.2993 | 17710.9 | 2490000 | 365000000 | 56000000000 | 0.4257 | 0.2249 | 0.0014 | 0.0000 | 0.0040 | 0.0000 | 0.0071 | 0.0000 | 0.0190 | 0.0025 | 0.0451 | 0.0167 | 0.0984 | 0.0362 | 0.1083 | 0.0292 | 0.1549 | 0.0442 | 0.5618 | 0.8712 | 0.0012 | 0.0000 | 0.0029 | 0.0000 | 0.0054 | 0.0000 | 0.0103 | 0.0017 | 0.0254 | 0.0129 | 0.0548 | 0.0241 | 0.0523 | 0.0146 | 0.0807 | 0.0226 | 0.7669 | 0.9241 | 0.0071 | 0.0059 | 0.0196 | 0.0294 | 0.0445 | 0.0471 | 0.0943 | 0.0824 | 0.1423 | 0.1765 | 0.1637 | 0.2176 | 0.1121 | 0.0706 | 0.1174 | 0.1647 | 0.2989 | 0.2059 | 0.0044 | 0.0083 | 0.0151 | 0.0432 | 0.0763 | 0.1122 | 0.1102 | 0.1336 | 0.4968 | 59 | 93 | 118 | 141 | 168 | 200 | 248 | 312 | 412 | 0.0015 | 56.43 | 6.903 | 0.2245 | 61663.9 | 23700000 | 10900000000 | 5660000000000 | 0.4849 | 0.1602 | 0.0169 | 0.0036 | 0.0784 | 0.0118 | 0.1858 | 0.0391 | 0.1701 | 0.0751 | 0.1725 | 0.1438 | 0.1556 | 0.1746 | 0.0941 | 0.1473 | 0.0760 | 0.1444 | 0.0507 | 0.2604 | 0.0020 | 0.0019 | 0.0040 | 0.0035 | 0.0106 | 0.0089 | 0.0323 | 0.0216 | 0.0751 | 0.0589 | 0.1280 | 0.0971 | 0.1154 | 0.0890 | 0.1260 | 0.1125 | 0.5066 | 0.6067 | 0.0017 | 0.0044 | 0.0121 | 0.0077 | 0.0113 | 0.0221 | 0.0459 | 0.0464 | 0.1013 | 0.1380 | 0.1636 | 0.1435 | 0.1022 | 0.1280 | 0.1411 | 0.1523 | 0.4208 | 0.3576 | 0.0020 | 0.0101 | 0.0181 | 0.0322 | 0.0938 | 0.1434 | 0.1139 | 0.1273 | 0.4591 |
| Hs 578T | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 380 | 140 | | 4015 | 11442 | 298.5 | 93.89 | 283.49 | 327.91 | 188 | 224 | 248 | 270 | 290 | 313 | 337 | 371 | 423 | 0.0718 | 821 | 0.641 | 110.89 | 16.16 | 3 | 0.0590 | 237 | 0.0005 | 119.77 | 7.721 | 0.1137 | 97912.3 | 34900000 | 13400000000 | 5490000000000 | 0.4228 | 0.1994 | 0.0000 | 0.0000 | 0.0005 | 0.0003 | 0.0078 | 0.0000 | 0.0352 | 0.0049 | 0.0906 | 0.0391 | 0.1684 | 0.0564 | 0.1361 | 0.0524 | 0.1522 | 0.0795 | 0.4092 | 0.7675 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0020 | 0.0000 | 0.0135 | 0.0016 | 0.0347 | 0.0237 | 0.0663 | 0.0307 | 0.0579 | 0.0234 | 0.0710 | 0.0373 | 0.7547 | 0.8833 | 0.0011 | 0.0093 | 0.0032 | 0.0023 | 0.0086 | 0.0163 | 0.0452 | 0.0629 | 0.0893 | 0.0979 | 0.1453 | 0.1375 | 0.0969 | 0.1235 | 0.1163 | 0.1142 | 0.4941 | 0.4359 | 0.0005 | 0.0005 | 0.0032 | 0.0244 | 0.0684 | 0.1087 | 0.0976 | 0.1124 | 0.5843 | 18 | 23 | 31 | 69 | 150 | 246 | 370 | 532 | 762 | 0.0260 | 64.88 | 6.232 | 0.4074 | 187886.0 | 166000000 | 173000000000 | 201000000000000 | 0.6183 | 0.1150 | 0.0315 | 0.0018 | 0.0954 | 0.0093 | 0.2028 | 0.0466 | 0.1778 | 0.0888 | 0.1759 | 0.1607 | 0.1389 | 0.1793 | 0.0880 | 0.1474 | 0.0528 | 0.1482 | 0.0370 | 0.2179 | 0.0008 | 0.0000 | 0.0015 | 0.0004 | 0.0054 | 0.0022 | 0.0149 | 0.0104 | 0.0492 | 0.0440 | 0.0677 | 0.0593 | 0.0620 | 0.0557 | 0.0989 | 0.0825 | 0.6996 | 0.7454 | 0.0014 | 0.0000 | 0.0038 | 0.0019 | 0.0049 | 0.0074 | 0.0181 | 0.0211 | 0.0585 | 0.0692 | 0.0937 | 0.0977 | 0.0766 | 0.0922 | 0.1110 | 0.1151 | 0.6320 | 0.5954 | 0.0005 | 0.0026 | 0.0062 | 0.0133 | 0.0554 | 0.0778 | 0.0700 | 0.1011 | 0.6730 |
| MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 212 | 744 | | 6614 | 10325 | 163.1 | 32.35 | 119.28 | 84.78 | 125 | 138 | 147 | 155 | 161 | 167 | 175 | 185 | 203 | 0.0792 | 818 | 1.172 | 127.35 | 40.25 | 1 | 0.0452 | 299 | 0.0020 | 27.70 | 6.559 | 0.2300 | 27650.6 | 4880000 | 902000000 | 175000000000 | 0.4500 | 0.2031 | 0.0002 | 0.0000 | 0.0008 | 0.0003 | 0.0033 | 0.0005 | 0.0157 | 0.0009 | 0.0518 | 0.0158 | 0.1045 | 0.0311 | 0.1239 | 0.0356 | 0.1680 | 0.0538 | 0.5318 | 0.8621 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0019 | 0.0000 | 0.0073 | 0.0005 | 0.0238 | 0.0110 | 0.0514 | 0.0224 | 0.0550 | 0.0146 | 0.0835 | 0.0286 | 0.7771 | 0.9229 | 0.0114 | 0.0090 | 0.0194 | 0.0495 | 0.0411 | 0.0495 | 0.1006 | 0.1802 | 0.1600 | 0.2117 | 0.1794 | 0.1757 | 0.1486 | 0.0991 | 0.1394 | 0.0991 | 0.2000 | 0.1261 | 0.0006 | 0.0063 | 0.0157 | 0.0466 | 0.0913 | 0.1326 | 0.1222 | 0.1698 | 0.4148 | 30 | 47 | 62 | 79 | 97 | 119 | 148 | 185 | 240 | 0.0026 | 32.10 | 6.579 | 0.2832 | 21415.5 | 4970000 | 1370000000 | 425000000000 | 0.5726 | 0.1051 | 0.0233 | 0.0012 | 0.1341 | 0.0059 | 0.2743 | 0.0446 | 0.1832 | 0.1006 | 0.1522 | 0.1877 | 0.1071 | 0.1954 | 0.0694 | 0.1475 | 0.0367 | 0.1460 | 0.0197 | 0.1709 | 0.0004 | 0.0005 | 0.0023 | 0.0009 | 0.0082 | 0.0027 | 0.0218 | 0.0148 | 0.0827 | 0.0624 | 0.1269 | 0.0968 | 0.1019 | 0.0859 | 0.1392 | 0.1237 | 0.5166 | 0.6124 | 0.0015 | 0.0023 | 0.0073 | 0.0051 | 0.0094 | 0.0167 | 0.0462 | 0.0607 | 0.1152 | 0.1293 | 0.1711 | 0.1795 | 0.1100 | 0.1215 | 0.1510 | 0.1484 | 0.3883 | 0.3364 | 0.0007 | 0.0041 | 0.0070 | 0.0374 | 0.0934 | 0.1539 | 0.1074 | 0.1421 | 0.4540 | ||
| MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 591 | 329 | | 4059 | 4051 | 149.9 | 44.98 | 152.81 | 103.02 | 95 | 110 | 122 | 134 | 145 | 156 | 170 | 185 | 211 | 0.1824 | 739 | 0.920 | 69.64 | 26.25 | 1 | 0.0493 | 200 | 0.0013 | 36.19 | 6.869 | 0.2026 | 24493.5 | 4340000 | 829000000 | 169000000000 | 0.4381 | 0.2179 | 0.0010 | 0.0000 | 0.0020 | 0.0006 | 0.0237 | 0.0015 | 0.0622 | 0.0050 | 0.1475 | 0.0394 | 0.2153 | 0.0977 | 0.1769 | 0.0924 | 0.1511 | 0.1146 | 0.2203 | 0.6487 | 0.0000 | 0.0000 | 0.0007 | 0.0000 | 0.0034 | 0.0008 | 0.0127 | 0.0016 | 0.0491 | 0.0255 | 0.1050 | 0.0516 | 0.0769 | 0.0408 | 0.0978 | 0.0574 | 0.6543 | 0.8222 | 0.0021 | 0.0071 | 0.0032 | 0.0095 | 0.0203 | 0.0309 | 0.0664 | 0.1164 | 0.1756 | 0.2019 | 0.1874 | 0.2233 | 0.1113 | 0.0879 | 0.1520 | 0.1164 | 0.2816 | 0.2067 | 0.0000 | 0.0011 | 0.0070 | 0.0316 | 0.1002 | 0.1522 | 0.0997 | 0.1442 | 0.4641 | 38 | 60 | 81 | 105 | 133 | 164 | 196 | 234 | 296 | 0.0029 | 26.57 | 6.397 | 0.3265 | 33960.4 | 9530000 | 3160000000 | 1200000000000 | 0.5229 | 0.1431 | 0.0171 | 0.0012 | 0.1148 | 0.0116 | 0.2369 | 0.0408 | 0.1685 | 0.0987 | 0.1709 | 0.1749 | 0.1258 | 0.2108 | 0.0733 | 0.1475 | 0.0635 | 0.1511 | 0.0293 | 0.1633 | 0.0000 | 0.0004 | 0.0037 | 0.0011 | 0.0064 | 0.0053 | 0.0320 | 0.0224 | 0.0859 | 0.0765 | 0.1293 | 0.1057 | 0.1028 | 0.0856 | 0.1325 | 0.1118 | 0.5073 | 0.5911 | 0.0037 | 0.0060 | 0.0073 | 0.0140 | 0.0190 | 0.0351 | 0.0467 | 0.0852 | 0.1402 | 0.1543 | 0.1958 | 0.1944 | 0.1242 | 0.1333 | 0.1570 | 0.1353 | 0.3061 | 0.2425 | 0.0017 | 0.0040 | 0.0090 | 0.0384 | 0.0942 | 0.1738 | 0.1196 | 0.1535 | 0.4058 |
| SK-BR-3 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 553 | 850 | | 1687 | 2459 | 300.5 | 204.06 | 15.65 | 29.61 | 110 | 143 | 172 | 196 | 226 | 271 | 333 | 444 | 654 | 0.1684 | 414 | 0.726 | 89.00 | 15.23 | 2 | 0.1114 | 188 | 0.0012 | 52.86 | 6.939 | 0.2192 | 131887.0 | 75200000 | 49500000000 | 35300000000000 | 0.3308 | 0.2934 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0059 | 0.0039 | 0.0676 | 0.0130 | 0.1618 | 0.0649 | 0.2176 | 0.1104 | 0.1294 | 0.0909 | 0.1147 | 0.1078 | 0.3029 | 0.6091 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0027 | 0.0102 | 0.0089 | 0.0422 | 0.0337 | 0.0588 | 0.0452 | 0.0409 | 0.0425 | 0.0537 | 0.0558 | 0.7941 | 0.8113 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0045 | 0.0000 | 0.0045 | 0.0056 | 0.0543 | 0.0446 | 0.0860 | 0.0864 | 0.0294 | 0.0362 | 0.0633 | 0.0585 | 0.7579 | 0.7688 | 0.0000 | 0.0000 | 0.0000 | 0.0100 | 0.0434 | 0.0701 | 0.0484 | 0.0668 | 0.7613 | 6 | 7 | 8 | 9 | 10 | 11 | 11 | 13 | 16 | 0.6120 | 0.70 | 1.147 | 0.8761 | 1121.1 | 209476 | 49200000 | 12700000000 | 0.5069 | 0.1463 | 0.1731 | 0.0340 | 0.1621 | 0.0635 | 0.1264 | 0.1020 | 0.1978 | 0.1422 | 0.1264 | 0.1592 | 0.1209 | 0.1494 | 0.0604 | 0.1476 | 0.0275 | 0.1127 | 0.0055 | 0.0894 | 0.1136 | 0.0296 | 0.0971 | 0.0553 | 0.0531 | 0.0872 | 0.1081 | 0.1153 | 0.1117 | 0.1379 | 0.1026 | 0.1254 | 0.0861 | 0.1347 | 0.1081 | 0.1160 | 0.2198 | 0.1986 | 0.0110 | 0.0000 | 0.0385 | 0.0060 | 0.0055 | 0.0060 | 0.0220 | 0.0482 | 0.1154 | 0.1024 | 0.1264 | 0.1265 | 0.1154 | 0.1205 | 0.1209 | 0.1325 | 0.4451 | 0.4578 | 0.0618 | 0.0579 | 0.0734 | 0.0463 | 0.0888 | 0.1004 | 0.0811 | 0.1197 | 0.3707 |
| MCF7 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 477 | 250 | | 5842 | 6724 | 472.6 | 109.57 | 64.97 | 82.36 | 352 | 384 | 409 | 431 | 454 | 480 | 513 | 551 | 621 | 0.1120 | 753 | 1.059 | 127.44 | 46.01 | 1 | 0.0580 | 339 | 0.0010 | 46.76 | 7.191 | 0.1916 | 235384.0 | 124000000 | 68700000000 | 40200000000000 | 0.4185 | 0.2273 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0051 | 0.0000 | 0.0183 | 0.0015 | 0.0595 | 0.0197 | 0.1231 | 0.0436 | 0.1215 | 0.0347 | 0.1414 | 0.0528 | 0.5311 | 0.8478 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0008 | 0.0000 | 0.0061 | 0.0000 | 0.0303 | 0.0139 | 0.0654 | 0.0255 | 0.0629 | 0.0177 | 0.0794 | 0.0279 | 0.7550 | 0.9150 | 0.0020 | 0.0082 | 0.0049 | 0.0109 | 0.0225 | 0.0136 | 0.0470 | 0.0625 | 0.1136 | 0.1223 | 0.1185 | 0.1929 | 0.0803 | 0.0870 | 0.1156 | 0.1304 | 0.4956 | 0.3723 | 0.0012 | 0.0040 | 0.0064 | 0.0302 | 0.0770 | 0.1132 | 0.0870 | 0.1140 | 0.5671 | 5 | 7 | 9 | 13 | 27 | 45 | 76 | 118 | 187 | 0.0898 | 5.57 | 4.185 | 0.6123 | 11003.2 | 2590000 | 720000000 | 223000000000 | 0.5988 | 0.0846 | 0.0147 | 0.0063 | 0.0939 | 0.0135 | 0.2413 | 0.0387 | 0.1971 | 0.0729 | 0.1823 | 0.1674 | 0.1050 | 0.2115 | 0.0958 | 0.1476 | 0.0405 | 0.1611 | 0.0295 | 0.1809 | 0.0004 | 0.0025 | 0.0000 | 0.0011 | 0.0016 | 0.0035 | 0.0130 | 0.0074 | 0.0438 | 0.0337 | 0.0686 | 0.0561 | 0.0603 | 0.0459 | 0.0832 | 0.0775 | 0.7292 | 0.7724 | 0.0000 | 0.0000 | 0.0015 | 0.0046 | 0.0040 | 0.0040 | 0.0206 | 0.0259 | 0.0667 | 0.0856 | 0.1003 | 0.1086 | 0.0832 | 0.0851 | 0.1169 | 0.1132 | 0.6068 | 0.5730 | 0.0000 | 0.0000 | 0.0044 | 0.0146 | 0.0521 | 0.0838 | 0.0710 | 0.1094 | 0.6648 | ||
| MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 320 | 667 | | 5012 | 4003 | 144.6 | 31.00 | 256.96 | 210.61 | 110 | 119 | 126 | 133 | 139 | 146 | 155 | 168 | 187 | 0.1699 | 680 | 1.061 | 130.67 | 36.72 | 1 | 0.0599 | 300 | 0.0023 | 22.41 | 6.404 | 0.2450 | 21873.6 | 3470000 | 577000000 | 101000000000 | 0.4357 | 0.2084 | 0.0000 | 0.0000 | 0.0015 | 0.0000 | 0.0059 | 0.0000 | 0.0223 | 0.0013 | 0.0711 | 0.0189 | 0.1355 | 0.0456 | 0.1443 | 0.0439 | 0.1875 | 0.0634 | 0.4320 | 0.8269 | 0.0000 | 0.0000 | 0.0007 | 0.0000 | 0.0028 | 0.0000 | 0.0083 | 0.0004 | 0.0355 | 0.0130 | 0.0649 | 0.0252 | 0.0675 | 0.0144 | 0.0966 | 0.0244 | 0.7237 | 0.9225 | 0.0073 | 0.0036 | 0.0158 | 0.0144 | 0.0280 | 0.0758 | 0.0767 | 0.1516 | 0.1571 | 0.1913 | 0.1705 | 0.1733 | 0.1255 | 0.1264 | 0.1437 | 0.1155 | 0.2753 | 0.1480 | 0.0038 | 0.0080 | 0.0127 | 0.0363 | 0.0930 | 0.1303 | 0.1085 | 0.1567 | 0.4507 | 33 | 63 | 100 | 155 | 208 | 265 | 333 | 424 | 568 | 0.0020 | 118.54 | 7.148 | 0.2176 | 110371.0 | 60900000 | 39200000000 | 28100000000000 | 0.4840 | 0.1833 | 0.0323 | 0.0038 | 0.1232 | 0.0212 | 0.2097 | 0.0613 | 0.2097 | 0.1272 | 0.1730 | 0.1779 | 0.1510 | 0.2059 | 0.0587 | 0.1476 | 0.0293 | 0.1272 | 0.0132 | 0.1279 | 0.0005 | 0.0000 | 0.0055 | 0.0033 | 0.0099 | 0.0087 | 0.0307 | 0.0229 | 0.0823 | 0.0715 | 0.1368 | 0.1227 | 0.1011 | 0.0932 | 0.1293 | 0.1165 | 0.5040 | 0.5611 | 0.0007 | 0.0055 | 0.0045 | 0.0028 | 0.0112 | 0.0148 | 0.0389 | 0.0572 | 0.1243 | 0.1210 | 0.1534 | 0.1681 | 0.1213 | 0.1385 | 0.1445 | 0.1376 | 0.4012 | 0.3546 | 0.0030 | 0.0066 | 0.0156 | 0.0361 | 0.0968 | 0.1437 | 0.1203 | 0.1371 | 0.4408 |
| MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 1240 | 782 | | 5520 | 5479 | 133.2 | 23.75 | 110.66 | 100.88 | 104 | 113 | 119 | 126 | 132 | 138 | 144 | 152 | 163 | 0.1374 | 753 | 0.999 | 91.29 | 24.70 | 1 | 0.0397 | 219 | 0.0031 | 14.38 | 6.066 | 0.2851 | 18294.8 | 2590000 | 379000000 | 57200000000 | 0.4125 | 0.2388 | 0.0000 | 0.0000 | 0.0015 | 0.0000 | 0.0041 | 0.0002 | 0.0212 | 0.0007 | 0.0442 | 0.0156 | 0.0934 | 0.0282 | 0.1204 | 0.0252 | 0.1646 | 0.0404 | 0.5507 | 0.8897 | 0.0000 | 0.0000 | 0.0006 | 0.0000 | 0.0012 | 0.0000 | 0.0083 | 0.0002 | 0.0228 | 0.0129 | 0.0452 | 0.0203 | 0.0504 | 0.0132 | 0.0765 | 0.0234 | 0.7949 | 0.9300 | 0.0226 | 0.0169 | 0.0155 | 0.0763 | 0.0523 | 0.1102 | 0.1088 | 0.1102 | 0.1638 | 0.1525 | 0.1723 | 0.2034 | 0.1201 | 0.1356 | 0.1554 | 0.0847 | 0.1893 | 0.1102 | 0.0033 | 0.0089 | 0.0118 | 0.0380 | 0.0687 | 0.1048 | 0.1063 | 0.1384 | 0.5197 | 27 | 36 | 47 | 60 | 75 | 95 | 123 | 168 | 249 | 0.0062 | 29.53 | 5.971 | 0.3642 | 22419.6 | 6640000 | 2430000000 | 1010000000000 | 0.6287 | 0.0903 | 0.0259 | 0.0043 | 0.1147 | 0.0103 | 0.2160 | 0.0511 | 0.1732 | 0.0983 | 0.1395 | 0.1836 | 0.1192 | 0.1825 | 0.0934 | 0.1477 | 0.0742 | 0.1266 | 0.0439 | 0.1955 | 0.0017 | 0.0020 | 0.0034 | 0.0039 | 0.0089 | 0.0098 | 0.0326 | 0.0219 | 0.0852 | 0.0732 | 0.1360 | 0.1023 | 0.1004 | 0.0859 | 0.1513 | 0.1366 | 0.4805 | 0.5644 | 0.0020 | 0.0025 | 0.0095 | 0.0033 | 0.0102 | 0.0172 | 0.0428 | 0.0582 | 0.1292 | 0.1534 | 0.1747 | 0.1838 | 0.1237 | 0.1017 | 0.1475 | 0.1403 | 0.3603 | 0.3396 | 0.0016 | 0.0064 | 0.0155 | 0.0321 | 0.1095 | 0.1474 | 0.1239 | 0.1394 | 0.4241 |
| MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1098 | 160 | | 13724 | 21102 | 109.6 | 32.03 | 139.67 | 113.32 | 75 | 84 | 91 | 97 | 104 | 112 | 121 | 133 | 152 | 0.0598 | 1262 | 0.543 | 155.77 | 38.28 | 1 | 0.0358 | 491 | 0.0012 | 36.99 | 7.099 | 0.2067 | 13040.5 | 1690000 | 237000000 | 36400000000 | 0.4757 | 0.1867 | 0.0010 | 0.0001 | 0.0041 | 0.0003 | 0.0130 | 0.0016 | 0.0426 | 0.0043 | 0.0995 | 0.0236 | 0.1665 | 0.0560 | 0.1630 | 0.0574 | 0.1878 | 0.0954 | 0.3226 | 0.7614 | 0.0005 | 0.0001 | 0.0013 | 0.0001 | 0.0034 | 0.0002 | 0.0125 | 0.0008 | 0.0402 | 0.0130 | 0.0734 | 0.0252 | 0.0716 | 0.0218 | 0.1009 | 0.0456 | 0.6963 | 0.8934 | 0.0044 | 0.0054 | 0.0078 | 0.0168 | 0.0271 | 0.0337 | 0.0640 | 0.0804 | 0.1118 | 0.1692 | 0.1406 | 0.1937 | 0.1349 | 0.1026 | 0.1386 | 0.1394 | 0.3707 | 0.2588 | 0.0024 | 0.0058 | 0.0129 | 0.0351 | 0.0814 | 0.1154 | 0.0950 | 0.1140 | 0.5380 | 25 | 40 | 60 | 83 | 110 | 142 | 177 | 222 | 298 | 0.0094 | 10.78 | 5.597 | 0.4544 | 32349.4 | 10000000 | 3730000000 | 1590000000000 | 0.5105 | 0.1695 | 0.0131 | 0.0019 | 0.0728 | 0.0040 | 0.1644 | 0.0224 | 0.1683 | 0.0713 | 0.1736 | 0.1476 | 0.1439 | 0.1890 | 0.1111 | 0.1477 | 0.0831 | 0.1506 | 0.0697 | 0.2653 | 0.0009 | 0.0007 | 0.0013 | 0.0014 | 0.0035 | 0.0034 | 0.0133 | 0.0126 | 0.0502 | 0.0386 | 0.0839 | 0.0657 | 0.0680 | 0.0578 | 0.1044 | 0.0854 | 0.6745 | 0.7344 | 0.0012 | 0.0013 | 0.0045 | 0.0041 | 0.0086 | 0.0141 | 0.0281 | 0.0380 | 0.0821 | 0.1031 | 0.1290 | 0.1509 | 0.1030 | 0.1107 | 0.1319 | 0.1375 | 0.5116 | 0.4403 | 0.0013 | 0.0019 | 0.0052 | 0.0196 | 0.0680 | 0.1022 | 0.0904 | 0.1250 | 0.5864 |
| MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1218 | 331 | | 5158 | 11255 | 109.5 | 27.54 | 210.24 | 157.90 | 76 | 87 | 94 | 101 | 107 | 113 | 121 | 132 | 147 | 0.0888 | 999 | 0.982 | 161.79 | 52.24 | 2 | 0.0812 | 419 | 0.0014 | 32.09 | 6.880 | 0.2109 | 12755.0 | 1570000 | 204000000 | 27800000000 | 0.4280 | 0.2240 | 0.0010 | 0.0000 | 0.0046 | 0.0002 | 0.0137 | 0.0020 | 0.0332 | 0.0061 | 0.0853 | 0.0250 | 0.1439 | 0.0581 | 0.1598 | 0.0664 | 0.1960 | 0.0836 | 0.3626 | 0.7585 | 0.0005 | 0.0000 | 0.0010 | 0.0000 | 0.0032 | 0.0010 | 0.0112 | 0.0022 | 0.0364 | 0.0170 | 0.0670 | 0.0376 | 0.0687 | 0.0309 | 0.1000 | 0.0426 | 0.7120 | 0.8686 | 0.0096 | 0.0140 | 0.0115 | 0.0197 | 0.0239 | 0.0337 | 0.0822 | 0.1489 | 0.1377 | 0.1601 | 0.1424 | 0.1573 | 0.1243 | 0.1433 | 0.1348 | 0.1180 | 0.3337 | 0.2051 | 0.0038 | 0.0059 | 0.0169 | 0.0418 | 0.0823 | 0.1283 | 0.1177 | 0.1346 | 0.4688 | 46 | 78 | 107 | 136 | 168 | 205 | 255 | 330 | 441 | 0.0032 | 32.72 | 6.476 | 0.3151 | 69130.2 | 29900000 | 15400000000 | 9000000000000 | 0.5329 | 0.1282 | 0.0180 | 0.0007 | 0.0912 | 0.0074 | 0.1973 | 0.0320 | 0.1694 | 0.0776 | 0.1551 | 0.1513 | 0.1470 | 0.1874 | 0.0989 | 0.1477 | 0.0755 | 0.1517 | 0.0476 | 0.2442 | 0.0007 | 0.0003 | 0.0018 | 0.0020 | 0.0065 | 0.0043 | 0.0235 | 0.0156 | 0.0685 | 0.0528 | 0.1185 | 0.0846 | 0.0952 | 0.0742 | 0.1250 | 0.1087 | 0.5602 | 0.6575 | 0.0026 | 0.0033 | 0.0058 | 0.0066 | 0.0151 | 0.0147 | 0.0422 | 0.0518 | 0.1013 | 0.1200 | 0.1487 | 0.1637 | 0.1117 | 0.1076 | 0.1414 | 0.1333 | 0.4312 | 0.3990 | 0.0007 | 0.0057 | 0.0119 | 0.0306 | 0.0952 | 0.1313 | 0.1048 | 0.1375 | 0.4823 |
| MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 166 | 253 | | 6270 | 6263 | 146.8 | 53.83 | 210.83 | 195.38 | 91 | 105 | 116 | 126 | 136 | 148 | 163 | 183 | 214 | 0.1284 | 804 | 0.784 | 97.01 | 20.88 | 2 | 0.0364 | 228 | 0.0012 | 46.26 | 7.074 | 0.1935 | 24453.4 | 4680000 | 1040000000 | 271000000000 | 0.4725 | 0.1765 | 0.0007 | 0.0000 | 0.0042 | 0.0002 | 0.0251 | 0.0014 | 0.0639 | 0.0074 | 0.1432 | 0.0380 | 0.2040 | 0.0897 | 0.1788 | 0.0986 | 0.1596 | 0.1272 | 0.2204 | 0.6374 | 0.0005 | 0.0000 | 0.0007 | 0.0002 | 0.0037 | 0.0007 | 0.0128 | 0.0035 | 0.0536 | 0.0227 | 0.0951 | 0.0435 | 0.0820 | 0.0411 | 0.1203 | 0.0647 | 0.6313 | 0.8237 | 0.0000 | 0.0027 | 0.0028 | 0.0199 | 0.0231 | 0.0292 | 0.0651 | 0.1089 | 0.1254 | 0.1169 | 0.1779 | 0.2058 | 0.1036 | 0.0943 | 0.1359 | 0.1262 | 0.3662 | 0.2961 | 0.0012 | 0.0042 | 0.0089 | 0.0386 | 0.0981 | 0.1463 | 0.1035 | 0.1332 | 0.4660 | 38 | 58 | 81 | 110 | 146 | 193 | 254 | 331 | 478 | 0.0038 | 52.97 | 6.523 | 0.2940 | 82615.2 | 46500000 | 32400000000 | 25600000000000 | 0.5390 | 0.1222 | 0.0251 | 0.0021 | 0.1137 | 0.0098 | 0.2109 | 0.0602 | 0.1891 | 0.0932 | 0.1683 | 0.1720 | 0.1311 | 0.1941 | 0.0678 | 0.1478 | 0.0612 | 0.1313 | 0.0328 | 0.1895 | 0.0004 | 0.0003 | 0.0021 | 0.0012 | 0.0039 | 0.0043 | 0.0189 | 0.0162 | 0.0754 | 0.0638 | 0.1190 | 0.1070 | 0.0829 | 0.0786 | 0.1187 | 0.1041 | 0.5786 | 0.6246 | 0.0011 | 0.0013 | 0.0016 | 0.0040 | 0.0080 | 0.0153 | 0.0366 | 0.0477 | 0.1115 | 0.1194 | 0.1476 | 0.1472 | 0.1041 | 0.1154 | 0.1391 | 0.1366 | 0.4503 | 0.4131 | 0.0009 | 0.0004 | 0.0043 | 0.0272 | 0.0858 | 0.1337 | 0.0923 | 0.1251 | 0.5302 |
| BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 226 | 604 | | 4693 | 21436 | 383.8 | 76.01 | 185.02 | 221.64 | 284 | 313 | 337 | 360 | 381 | 402 | 425 | 454 | 486 | 0.0416 | 891 | 1.052 | 130.17 | 34.01 | 1 | 0.0641 | 301 | 0.0008 | 47.52 | 7.327 | 0.1592 | 153105.0 | 63300000 | 27000000000 | 11900000000000 | 0.3995 | 0.2470 | 0.0003 | 0.0000 | 0.0010 | 0.0000 | 0.0023 | 0.0002 | 0.0165 | 0.0017 | 0.0621 | 0.0177 | 0.1229 | 0.0293 | 0.1371 | 0.0275 | 0.1688 | 0.0446 | 0.4889 | 0.8790 | 0.0000 | 0.0000 | 0.0005 | 0.0000 | 0.0010 | 0.0000 | 0.0073 | 0.0015 | 0.0275 | 0.0148 | 0.0536 | 0.0238 | 0.0573 | 0.0171 | 0.0744 | 0.0278 | 0.7785 | 0.9150 | 0.0000 | 0.0000 | 0.0120 | 0.0000 | 0.0156 | 0.0000 | 0.0648 | 0.0000 | 0.1212 | 0.0000 | 0.1633 | 0.0000 | 0.1357 | 0.0000 | 0.1465 | 0.0000 | 0.3409 | 0.0000 | 0.0000 | 0.0009 | 0.0069 | 0.0221 | 0.0711 | 0.1111 | 0.0954 | 0.1176 | 0.5748 | 15 | 18 | 24 | 44 | 80 | 141 | 230 | 343 | 529 | 0.0288 | 19.62 | 5.529 | 0.4998 | 83352.2 | 50500000 | 35500000000 | 27500000000000 | 0.4199 | 0.2507 | 0.0207 | 0.0005 | 0.0995 | 0.0062 | 0.2392 | 0.0328 | 0.2041 | 0.0859 | 0.1593 | 0.1798 | 0.1282 | 0.2251 | 0.0610 | 0.1479 | 0.0518 | 0.1262 | 0.0362 | 0.1956 | 0.0004 | 0.0000 | 0.0006 | 0.0003 | 0.0016 | 0.0010 | 0.0080 | 0.0073 | 0.0421 | 0.0351 | 0.0732 | 0.0620 | 0.0459 | 0.0433 | 0.0727 | 0.0653 | 0.7556 | 0.7856 | 0.0000 | 0.0003 | 0.0009 | 0.0012 | 0.0020 | 0.0024 | 0.0131 | 0.0137 | 0.0524 | 0.0608 | 0.0851 | 0.0996 | 0.0622 | 0.0649 | 0.0907 | 0.0941 | 0.6935 | 0.6629 | 0.0001 | 0.0005 | 0.0023 | 0.0104 | 0.0496 | 0.0769 | 0.0547 | 0.0770 | 0.7284 |
| Hs 578T | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 274 | 724 | | 833 | 13982 | 37.7 | 9.22 | 181.15 | 216.84 | 28 | 30 | 32 | 34 | 36 | 38 | 40 | 44 | 50 | 0.0473 | 662 | 1.199 | 23.54 | 8.94 | 3 | 0.0732 | 61 | 0.0229 | 2.86 | 4.160 | 0.4919 | 1505.4 | 64089 | 2920000 | 142000000 | 0.4024 | 0.2135 | 0.0039 | 0.0000 | 0.0197 | 0.0000 | 0.0197 | 0.0000 | 0.0907 | 0.0156 | 0.1243 | 0.0650 | 0.1460 | 0.0728 | 0.1913 | 0.1027 | 0.2012 | 0.1352 | 0.2032 | 0.6086 | 0.0031 | 0.0000 | 0.0108 | 0.0000 | 0.0154 | 0.0000 | 0.0555 | 0.0132 | 0.0709 | 0.0505 | 0.0755 | 0.0457 | 0.1248 | 0.0721 | 0.1171 | 0.0805 | 0.5270 | 0.7380 | 0.0141 | 0.0317 | 0.0070 | 0.0317 | 0.0211 | 0.0317 | 0.0845 | 0.0794 | 0.1268 | 0.1746 | 0.1479 | 0.1587 | 0.0775 | 0.1429 | 0.1831 | 0.1111 | 0.3380 | 0.2381 | 0.0089 | 0.0417 | 0.0357 | 0.0774 | 0.0923 | 0.1220 | 0.1042 | 0.1399 | 0.3780 | 13 | 15 | 18 | 25 | 72 | 155 | 247 | 356 | 505 | 0.1047 | 25.13 | 4.988 | 0.5234 | 79833.1 | 46100000 | 31400000000 | 24300000000000 | 0.5786 | 0.1133 | 0.0295 | 0.0009 | 0.1412 | 0.0151 | 0.2513 | 0.0722 | 0.1854 | 0.1324 | 0.1750 | 0.2019 | 0.1161 | 0.2027 | 0.0537 | 0.1479 | 0.0286 | 0.1209 | 0.0191 | 0.1062 | 0.0005 | 0.0000 | 0.0021 | 0.0008 | 0.0031 | 0.0022 | 0.0102 | 0.0085 | 0.0401 | 0.0383 | 0.0610 | 0.0504 | 0.0571 | 0.0510 | 0.0875 | 0.0745 | 0.7384 | 0.7744 | 0.0004 | 0.0002 | 0.0013 | 0.0015 | 0.0054 | 0.0051 | 0.0173 | 0.0245 | 0.0542 | 0.0646 | 0.0886 | 0.0970 | 0.0864 | 0.1030 | 0.1156 | 0.1191 | 0.6309 | 0.5849 | 0.0004 | 0.0035 | 0.0025 | 0.0146 | 0.0434 | 0.0766 | 0.0726 | 0.0991 | 0.6873 |