High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
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| Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
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| BT-20 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 547 | 289 | | 11285 | 27072 | 244.5 | 58.73 | 197.38 | 232.26 | 172 | 193 | 209 | 224 | 239 | 255 | 274 | 296 | 325 | 0.0436 | 1181 | 1.186 | 113.74 | 45.89 | 1 | 0.0262 | 296 | 0.0006 | 59.04 | 7.598 | 0.1608 | 63242.6 | 17200000 | 4920000000 | 1470000000000 | 0.4595 | 0.1977 | 0.0000 | 0.0000 | 0.0008 | 0.0001 | 0.0038 | 0.0003 | 0.0222 | 0.0030 | 0.0838 | 0.0183 | 0.1665 | 0.0428 | 0.1519 | 0.0447 | 0.1695 | 0.0687 | 0.4015 | 0.8221 | 0.0000 | 0.0000 | 0.0003 | 0.0001 | 0.0009 | 0.0000 | 0.0056 | 0.0015 | 0.0329 | 0.0117 | 0.0689 | 0.0232 | 0.0624 | 0.0202 | 0.0836 | 0.0302 | 0.7454 | 0.9132 | 0.0042 | 0.0118 | 0.0042 | 0.0251 | 0.0161 | 0.0340 | 0.0589 | 0.0991 | 0.1158 | 0.1731 | 0.1866 | 0.1864 | 0.1001 | 0.1080 | 0.1387 | 0.1391 | 0.3753 | 0.2234 | 0.0010 | 0.0019 | 0.0079 | 0.0250 | 0.0784 | 0.1238 | 0.0992 | 0.1291 | 0.5338 | 14 | 18 | 26 | 48 | 94 | 162 | 255 | 375 | 541 | 0.0240 | 59.33 | 6.100 | 0.4045 | 92900.8 | 59800000 | 46700000000 | 42500000000000 | 0.3821 | 0.2440 | 0.0415 | 0.0013 | 0.1747 | 0.0119 | 0.3178 | 0.1184 | 0.1407 | 0.1403 | 0.1199 | 0.1896 | 0.0884 | 0.1946 | 0.0465 | 0.1232 | 0.0336 | 0.1013 | 0.0369 | 0.1196 | 0.0001 | 0.0002 | 0.0000 | 0.0003 | 0.0009 | 0.0010 | 0.0080 | 0.0057 | 0.0480 | 0.0394 | 0.0973 | 0.0776 | 0.0603 | 0.0509 | 0.0905 | 0.0756 | 0.6949 | 0.7492 | 0.0002 | 0.0004 | 0.0020 | 0.0014 | 0.0027 | 0.0026 | 0.0159 | 0.0171 | 0.0664 | 0.0775 | 0.1207 | 0.1335 | 0.0813 | 0.0857 | 0.1106 | 0.1232 | 0.6001 | 0.5585 | 0.0001 | 0.0006 | 0.0019 | 0.0122 | 0.0586 | 0.1142 | 0.0705 | 0.1007 | 0.6412 |
| MDA-MB-231 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 509 | 817 | | 5202 | 13328 | 498.6 | 85.62 | 75.42 | 193.51 | 376 | 424 | 460 | 483 | 503 | 525 | 551 | 573 | 600 | 0.0606 | 808 | 0.924 | 121.38 | 32.28 | 1 | 0.0600 | 312 | 0.0016 | 14.59 | 6.726 | 0.2939 | 255905.0 | 135000000 | 72700000000 | 40000000000000 | 0.4179 | 0.2243 | 0.0000 | 0.0000 | 0.0013 | 0.0000 | 0.0023 | 0.0002 | 0.0100 | 0.0010 | 0.0267 | 0.0117 | 0.0460 | 0.0271 | 0.0409 | 0.0125 | 0.0779 | 0.0230 | 0.7949 | 0.9246 | 0.0000 | 0.0000 | 0.0005 | 0.0000 | 0.0007 | 0.0000 | 0.0041 | 0.0008 | 0.0129 | 0.0112 | 0.0226 | 0.0247 | 0.0142 | 0.0106 | 0.0293 | 0.0185 | 0.9158 | 0.9342 | 0.0074 | 0.0227 | 0.0185 | 0.0000 | 0.0444 | 0.0455 | 0.0628 | 0.0455 | 0.0795 | 0.1591 | 0.1109 | 0.1364 | 0.1146 | 0.1136 | 0.1109 | 0.1364 | 0.4510 | 0.3409 | 0.0022 | 0.0041 | 0.0081 | 0.0144 | 0.0276 | 0.0398 | 0.0446 | 0.0692 | 0.7901 | 8 | 10 | 11 | 12 | 14 | 17 | 27 | 59 | 186 | 0.2830 | 9.88 | 2.941 | 0.7317 | 43131.2 | 46900000 | 63500000000 | 95400000000000 | 0.3571 | 0.2342 | 0.0717 | 0.0047 | 0.2131 | 0.0292 | 0.2384 | 0.1318 | 0.1751 | 0.1111 | 0.1245 | 0.1770 | 0.0802 | 0.2062 | 0.0422 | 0.1234 | 0.0295 | 0.1036 | 0.0253 | 0.1130 | 0.0008 | 0.0003 | 0.0011 | 0.0036 | 0.0019 | 0.0062 | 0.0121 | 0.0147 | 0.0524 | 0.0421 | 0.0746 | 0.0718 | 0.0543 | 0.0492 | 0.0758 | 0.0744 | 0.7271 | 0.7378 | 0.0000 | 0.0005 | 0.0009 | 0.0010 | 0.0023 | 0.0025 | 0.0138 | 0.0125 | 0.0555 | 0.0609 | 0.0909 | 0.0973 | 0.0564 | 0.0579 | 0.0844 | 0.0868 | 0.6957 | 0.6806 | 0.0004 | 0.0017 | 0.0008 | 0.0138 | 0.0522 | 0.0823 | 0.0547 | 0.0852 | 0.7090 | ||
| MDA-MB-231 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 154 | 245 | | 7441 | 18098 | 595.1 | 99.87 | 158.05 | 276.24 | 459 | 515 | 549 | 576 | 598 | 618 | 640 | 669 | 725 | 0.0530 | 960 | 0.791 | 112.90 | 27.89 | 2 | 0.0372 | 277 | 0.0011 | 26.39 | 7.165 | 0.2288 | 364116.0 | 229000000 | 147000000000 | 96900000000000 | 0.4475 | 0.1984 | 0.0002 | 0.0000 | 0.0007 | 0.0001 | 0.0016 | 0.0000 | 0.0053 | 0.0005 | 0.0258 | 0.0124 | 0.0455 | 0.0206 | 0.0458 | 0.0151 | 0.0692 | 0.0230 | 0.8059 | 0.9282 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0020 | 0.0003 | 0.0163 | 0.0116 | 0.0267 | 0.0174 | 0.0252 | 0.0115 | 0.0358 | 0.0181 | 0.8938 | 0.9412 | 0.0093 | 0.0000 | 0.0093 | 0.0000 | 0.0093 | 0.0000 | 0.0292 | 0.0000 | 0.0560 | 0.0000 | 0.0840 | 0.0000 | 0.0793 | 0.0000 | 0.1039 | 0.0000 | 0.6196 | 0.0000 | 0.0018 | 0.0036 | 0.0094 | 0.0214 | 0.0420 | 0.0641 | 0.0646 | 0.0876 | 0.7055 | 11 | 14 | 17 | 20 | 25 | 35 | 85 | 239 | 575 | 0.1535 | 16.74 | 4.037 | 0.6476 | 101285.0 | 90600000 | 95000000000 | 112000000000000 | 0.3437 | 0.2785 | 0.0470 | 0.0020 | 0.1678 | 0.0214 | 0.1893 | 0.0935 | 0.1530 | 0.1136 | 0.1732 | 0.1877 | 0.0980 | 0.1717 | 0.0779 | 0.1236 | 0.0671 | 0.1142 | 0.0268 | 0.1723 | 0.0002 | 0.0000 | 0.0008 | 0.0002 | 0.0008 | 0.0013 | 0.0102 | 0.0086 | 0.0376 | 0.0335 | 0.0599 | 0.0539 | 0.0436 | 0.0392 | 0.0626 | 0.0588 | 0.7843 | 0.8046 | 0.0000 | 0.0003 | 0.0012 | 0.0000 | 0.0042 | 0.0040 | 0.0138 | 0.0138 | 0.0413 | 0.0458 | 0.0655 | 0.0684 | 0.0487 | 0.0468 | 0.0667 | 0.0620 | 0.7586 | 0.7589 | 0.0002 | 0.0007 | 0.0023 | 0.0114 | 0.0416 | 0.0654 | 0.0444 | 0.0633 | 0.7707 |
| SK-BR-3 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 400 | 407 | | 6276 | 11399 | 375.7 | 86.02 | 140.41 | 164.45 | 245 | 323 | 357 | 378 | 396 | 413 | 428 | 444 | 463 | 0.0798 | 910 | 1.138 | 23.43 | 8.49 | 5 | 0.0099 | 62 | 0.0020 | 19.90 | 6.638 | 0.2782 | 148520.0 | 60600000 | 25300000000 | 10700000000000 | 0.3938 | 0.2401 | 0.0005 | 0.0000 | 0.0014 | 0.0000 | 0.0021 | 0.0000 | 0.0137 | 0.0000 | 0.0354 | 0.0108 | 0.0722 | 0.0252 | 0.0748 | 0.0104 | 0.1107 | 0.0183 | 0.6891 | 0.9352 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0137 | 0.0108 | 0.0298 | 0.0252 | 0.0216 | 0.0104 | 0.0319 | 0.0169 | 0.9017 | 0.9367 | 0.0072 | 1.0000 | 0.0184 | 0.0000 | 0.0419 | 0.0000 | 0.0593 | 0.0000 | 0.0992 | 0.0000 | 0.1329 | 0.0000 | 0.1299 | 0.0000 | 0.1227 | 0.0000 | 0.3885 | 0.0000 | 0.0000 | 0.0010 | 0.0031 | 0.0067 | 0.0347 | 0.0601 | 0.0515 | 0.0772 | 0.7656 | 9 | 11 | 15 | 29 | 67 | 119 | 185 | 272 | 389 | 0.0593 | 7.25 | 4.451 | 0.5348 | 46754.1 | 20300000 | 10200000000 | 5650000000000 | 0.4511 | 0.1880 | 0.0237 | 0.0010 | 0.1225 | 0.0110 | 0.2381 | 0.0628 | 0.1729 | 0.1187 | 0.1275 | 0.1830 | 0.1265 | 0.1945 | 0.0810 | 0.1237 | 0.0632 | 0.1062 | 0.0445 | 0.1990 | 0.0000 | 0.0000 | 0.0008 | 0.0002 | 0.0017 | 0.0009 | 0.0089 | 0.0072 | 0.0450 | 0.0402 | 0.0820 | 0.0693 | 0.0542 | 0.0504 | 0.0858 | 0.0775 | 0.7214 | 0.7543 | 0.0003 | 0.0003 | 0.0030 | 0.0015 | 0.0041 | 0.0034 | 0.0160 | 0.0153 | 0.0574 | 0.0644 | 0.0907 | 0.1103 | 0.0655 | 0.0754 | 0.1045 | 0.1051 | 0.6586 | 0.6243 | 0.0002 | 0.0002 | 0.0019 | 0.0112 | 0.0594 | 0.0827 | 0.0622 | 0.0946 | 0.6875 |
| MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 208 | 697 | | 4527 | 6306 | 102.3 | 37.27 | 112.28 | 143.75 | 55 | 71 | 81 | 90 | 99 | 108 | 118 | 131 | 151 | 0.0815 | 514 | 0.356 | 141.55 | 33.02 | 1 | 0.1199 | 543 | 0.0021 | 18.08 | 6.438 | 0.2850 | 11862.3 | 1530000 | 217000000 | 33600000000 | 0.4631 | 0.1918 | 0.0025 | 0.0009 | 0.0066 | 0.0006 | 0.0244 | 0.0036 | 0.0533 | 0.0097 | 0.1102 | 0.0425 | 0.1554 | 0.0857 | 0.1640 | 0.0808 | 0.1971 | 0.1227 | 0.2864 | 0.6534 | 0.0000 | 0.0005 | 0.0003 | 0.0003 | 0.0054 | 0.0021 | 0.0123 | 0.0049 | 0.0377 | 0.0210 | 0.0595 | 0.0395 | 0.0687 | 0.0333 | 0.1013 | 0.0546 | 0.7149 | 0.8438 | 0.0025 | 0.0115 | 0.0025 | 0.0263 | 0.0193 | 0.0197 | 0.0495 | 0.0609 | 0.1050 | 0.1184 | 0.1310 | 0.1760 | 0.1125 | 0.1250 | 0.1453 | 0.1612 | 0.4324 | 0.3010 | 0.0009 | 0.0033 | 0.0127 | 0.0216 | 0.0701 | 0.1040 | 0.0861 | 0.1092 | 0.5920 | 15 | 19 | 25 | 33 | 49 | 75 | 115 | 180 | 306 | 0.0287 | 20.58 | 5.086 | 0.4862 | 33266.2 | 15000000 | 8150000000 | 4970000000000 | 0.6440 | 0.0881 | 0.0377 | 0.0048 | 0.1319 | 0.0168 | 0.1852 | 0.0743 | 0.1397 | 0.1086 | 0.1570 | 0.1829 | 0.1287 | 0.1589 | 0.0958 | 0.1238 | 0.0628 | 0.1286 | 0.0612 | 0.2013 | 0.0013 | 0.0007 | 0.0027 | 0.0015 | 0.0080 | 0.0067 | 0.0212 | 0.0176 | 0.0734 | 0.0639 | 0.1008 | 0.1002 | 0.0787 | 0.0740 | 0.1084 | 0.1073 | 0.6055 | 0.6279 | 0.0018 | 0.0028 | 0.0025 | 0.0035 | 0.0135 | 0.0063 | 0.0308 | 0.0232 | 0.0776 | 0.0752 | 0.1145 | 0.1308 | 0.0844 | 0.0893 | 0.1041 | 0.1069 | 0.5708 | 0.5619 | 0.0016 | 0.0057 | 0.0109 | 0.0274 | 0.0677 | 0.1117 | 0.0858 | 0.1101 | 0.5791 |
| MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 472 | 429 | | 2702 | 12483 | 298.7 | 39.90 | 33.75 | 65.19 | 243 | 264 | 280 | 292 | 303 | 312 | 321 | 330 | 347 | 0.0569 | 710 | 0.587 | 156.06 | 44.65 | 2 | 0.1991 | 538 | 0.0038 | 12.01 | 5.909 | 0.3178 | 90794.9 | 28100000 | 8800000000 | 2800000000000 | 0.4181 | 0.2189 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0082 | 0.0004 | 0.0381 | 0.0222 | 0.0559 | 0.0359 | 0.0563 | 0.0200 | 0.0858 | 0.0333 | 0.7552 | 0.8882 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0045 | 0.0004 | 0.0288 | 0.0222 | 0.0365 | 0.0359 | 0.0337 | 0.0200 | 0.0483 | 0.0333 | 0.8479 | 0.8882 | 0.0064 | 0.0000 | 0.0446 | 0.0000 | 0.0318 | 0.0000 | 0.1019 | 0.0000 | 0.1338 | 0.0000 | 0.1656 | 0.0000 | 0.1529 | 0.0000 | 0.1338 | 0.0000 | 0.2293 | 0.0000 | 0.0000 | 0.0014 | 0.0095 | 0.0210 | 0.0535 | 0.0947 | 0.0947 | 0.1238 | 0.6015 | 7 | 9 | 10 | 11 | 13 | 16 | 21 | 29 | 72 | 0.2585 | 2.84 | 2.563 | 0.8124 | 5388.1 | 1890000 | 937000000 | 558000000000 | 0.6147 | 0.0974 | 0.0312 | 0.0161 | 0.0775 | 0.0194 | 0.0763 | 0.0317 | 0.1329 | 0.0506 | 0.1699 | 0.1013 | 0.1642 | 0.1079 | 0.1780 | 0.1240 | 0.1202 | 0.1614 | 0.0497 | 0.3876 | 0.0063 | 0.0091 | 0.0118 | 0.0101 | 0.0074 | 0.0133 | 0.0221 | 0.0195 | 0.0505 | 0.0405 | 0.0660 | 0.0549 | 0.0705 | 0.0613 | 0.0989 | 0.0965 | 0.6665 | 0.6947 | 0.0038 | 0.0000 | 0.0065 | 0.0043 | 0.0076 | 0.0049 | 0.0244 | 0.0232 | 0.0455 | 0.0452 | 0.0764 | 0.0757 | 0.0585 | 0.0550 | 0.0748 | 0.0794 | 0.7026 | 0.7123 | 0.0014 | 0.0082 | 0.0096 | 0.0227 | 0.0537 | 0.0719 | 0.0637 | 0.0928 | 0.6761 |
| MCF7 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 608 | 285 | | 12711 | 40214 | 295.5 | 67.78 | 143.73 | 163.15 | 209 | 239 | 260 | 277 | 293 | 309 | 328 | 350 | 384 | 0.0353 | 1418 | 1.016 | 119.62 | 46.69 | 2 | 0.0271 | 344 | 0.0013 | 26.32 | 6.921 | 0.2277 | 91894.8 | 30000000 | 10200000000 | 3620000000000 | 0.4370 | 0.2187 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0043 | 0.0006 | 0.0194 | 0.0020 | 0.0643 | 0.0160 | 0.1388 | 0.0422 | 0.1306 | 0.0429 | 0.1606 | 0.0610 | 0.4809 | 0.8354 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0008 | 0.0001 | 0.0053 | 0.0011 | 0.0274 | 0.0105 | 0.0590 | 0.0245 | 0.0510 | 0.0194 | 0.0701 | 0.0291 | 0.7861 | 0.9154 | 0.0071 | 0.0128 | 0.0075 | 0.0192 | 0.0179 | 0.0417 | 0.0613 | 0.1330 | 0.1289 | 0.1875 | 0.1811 | 0.2051 | 0.1097 | 0.0865 | 0.1506 | 0.1330 | 0.3358 | 0.1811 | 0.0008 | 0.0024 | 0.0064 | 0.0265 | 0.0750 | 0.1260 | 0.1010 | 0.1299 | 0.5321 | 11 | 17 | 28 | 49 | 80 | 122 | 178 | 254 | 371 | 0.0435 | 17.85 | 5.232 | 0.4864 | 47276.4 | 22300000 | 13100000000 | 8910000000000 | 0.4347 | 0.1843 | 0.0559 | 0.0013 | 0.1725 | 0.0173 | 0.2681 | 0.1183 | 0.1475 | 0.1465 | 0.1431 | 0.1771 | 0.0944 | 0.1809 | 0.0533 | 0.1241 | 0.0376 | 0.1058 | 0.0276 | 0.1288 | 0.0001 | 0.0001 | 0.0004 | 0.0006 | 0.0019 | 0.0015 | 0.0116 | 0.0097 | 0.0649 | 0.0509 | 0.1109 | 0.0898 | 0.0752 | 0.0672 | 0.1098 | 0.0956 | 0.6253 | 0.6846 | 0.0006 | 0.0007 | 0.0011 | 0.0013 | 0.0036 | 0.0075 | 0.0213 | 0.0276 | 0.0840 | 0.0988 | 0.1417 | 0.1531 | 0.0910 | 0.0952 | 0.1254 | 0.1330 | 0.5313 | 0.4828 | 0.0003 | 0.0013 | 0.0032 | 0.0164 | 0.0787 | 0.1225 | 0.0861 | 0.1208 | 0.5707 |
| Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 644 | 509 | | 752 | 2601 | 109.3 | 22.70 | 27.66 | 36.83 | 79 | 89 | 97 | 104 | 110 | 117 | 123 | 130 | 139 | 0.1303 | 339 | 0.980 | 171.76 | 54.15 | 1 | 0.6197 | 466 | 0.0023 | 47.96 | 6.181 | 0.1607 | 12466.6 | 1470000 | 179000000 | 22400000000 | 0.3827 | 0.2423 | 0.0000 | 0.0000 | 0.0043 | 0.0000 | 0.0151 | 0.0000 | 0.0538 | 0.0042 | 0.1075 | 0.0379 | 0.1613 | 0.0618 | 0.1527 | 0.0520 | 0.2022 | 0.0758 | 0.3032 | 0.7683 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0016 | 0.0000 | 0.0114 | 0.0041 | 0.0507 | 0.0346 | 0.0654 | 0.0553 | 0.0670 | 0.0346 | 0.1029 | 0.0581 | 0.7010 | 0.8133 | 0.0204 | 0.0000 | 0.0272 | 0.0909 | 0.0612 | 0.3636 | 0.0952 | 0.2727 | 0.1837 | 0.0909 | 0.1361 | 0.1818 | 0.1633 | 0.0000 | 0.1769 | 0.0000 | 0.1361 | 0.0000 | 0.0000 | 0.0025 | 0.0101 | 0.0404 | 0.0783 | 0.1364 | 0.1364 | 0.1338 | 0.4621 | 13 | 14 | 15 | 16 | 17 | 18 | 21 | 29 | 50 | 0.5312 | 1.01 | 1.471 | 0.9002 | 2121.0 | 439440 | 138000000 | 49900000000 | 0.6286 | 0.0988 | 0.0545 | 0.0328 | 0.0955 | 0.0864 | 0.2136 | 0.1351 | 0.2136 | 0.1033 | 0.1727 | 0.1360 | 0.1091 | 0.1360 | 0.0909 | 0.1241 | 0.0364 | 0.1311 | 0.0136 | 0.1152 | 0.0104 | 0.0219 | 0.0104 | 0.0629 | 0.0207 | 0.0950 | 0.0370 | 0.0673 | 0.1111 | 0.0994 | 0.1156 | 0.0892 | 0.1319 | 0.1001 | 0.1452 | 0.1235 | 0.4178 | 0.3406 | 0.0000 | 0.0000 | 0.0022 | 0.0249 | 0.0198 | 0.0305 | 0.0440 | 0.0693 | 0.1604 | 0.1662 | 0.1758 | 0.1801 | 0.1297 | 0.1468 | 0.1714 | 0.1634 | 0.2967 | 0.2188 | 0.0036 | 0.0073 | 0.0146 | 0.0419 | 0.1421 | 0.1512 | 0.1275 | 0.1658 | 0.3461 |
| MCF7 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1040 | 910 | | 3585 | 10231 | 344.3 | 84.59 | 34.10 | 76.86 | 243 | 270 | 294 | 317 | 338 | 360 | 384 | 412 | 458 | 0.0777 | 795 | 0.975 | 80.16 | 26.08 | 1 | 0.0555 | 199 | 0.0010 | 48.18 | 7.091 | 0.1715 | 125705.0 | 48500000 | 19700000000 | 8380000000000 | 0.4417 | 0.2214 | 0.0005 | 0.0000 | 0.0029 | 0.0000 | 0.0058 | 0.0006 | 0.0346 | 0.0056 | 0.1029 | 0.0262 | 0.1587 | 0.0586 | 0.1640 | 0.0586 | 0.1722 | 0.0873 | 0.3583 | 0.7630 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0014 | 0.0006 | 0.0122 | 0.0029 | 0.0480 | 0.0161 | 0.0735 | 0.0365 | 0.0724 | 0.0276 | 0.0882 | 0.0419 | 0.7031 | 0.8745 | 0.0056 | 0.0041 | 0.0014 | 0.0331 | 0.0324 | 0.0455 | 0.0606 | 0.0909 | 0.1437 | 0.2066 | 0.1521 | 0.1901 | 0.1211 | 0.1116 | 0.1563 | 0.1570 | 0.3268 | 0.1612 | 0.0006 | 0.0041 | 0.0094 | 0.0241 | 0.0700 | 0.1329 | 0.0988 | 0.1424 | 0.5176 | 5 | 6 | 6 | 8 | 9 | 10 | 14 | 28 | 84 | 0.2835 | 3.77 | 2.562 | 0.7553 | 7069.4 | 2850000 | 1600000000 | 1100000000000 | 0.6411 | 0.0755 | 0.0751 | 0.0073 | 0.1503 | 0.0125 | 0.2306 | 0.0658 | 0.2098 | 0.1524 | 0.1710 | 0.1994 | 0.0984 | 0.1754 | 0.0492 | 0.1242 | 0.0130 | 0.1420 | 0.0026 | 0.1211 | 0.0063 | 0.0020 | 0.0073 | 0.0041 | 0.0078 | 0.0138 | 0.0195 | 0.0292 | 0.0640 | 0.0604 | 0.0762 | 0.0835 | 0.0703 | 0.0722 | 0.0996 | 0.1078 | 0.6489 | 0.6271 | 0.0012 | 0.0040 | 0.0030 | 0.0020 | 0.0084 | 0.0080 | 0.0247 | 0.0172 | 0.0596 | 0.0669 | 0.0915 | 0.0948 | 0.0686 | 0.0749 | 0.1113 | 0.1021 | 0.6318 | 0.6302 | 0.0027 | 0.0027 | 0.0092 | 0.0223 | 0.0566 | 0.0886 | 0.0691 | 0.1033 | 0.6455 |
| MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 469 | 396 | | 3985 | 3374 | 160.1 | 46.65 | 190.25 | 141.76 | 107 | 121 | 132 | 142 | 153 | 165 | 177 | 195 | 221 | 0.2110 | 712 | 0.988 | 83.24 | 28.02 | 1 | 0.0575 | 229 | 0.0012 | 50.08 | 6.991 | 0.1783 | 27806.5 | 5240000 | 1070000000 | 235000000000 | 0.4379 | 0.2135 | 0.0010 | 0.0000 | 0.0005 | 0.0000 | 0.0144 | 0.0017 | 0.0460 | 0.0032 | 0.1321 | 0.0326 | 0.1991 | 0.0843 | 0.1709 | 0.0837 | 0.1728 | 0.1160 | 0.2633 | 0.6784 | 0.0007 | 0.0000 | 0.0003 | 0.0000 | 0.0007 | 0.0003 | 0.0098 | 0.0016 | 0.0480 | 0.0199 | 0.0912 | 0.0482 | 0.0784 | 0.0364 | 0.0966 | 0.0566 | 0.6743 | 0.8371 | 0.0069 | 0.0079 | 0.0023 | 0.0237 | 0.0230 | 0.0211 | 0.0746 | 0.0868 | 0.1389 | 0.2237 | 0.1929 | 0.2053 | 0.1114 | 0.0974 | 0.1389 | 0.1316 | 0.3111 | 0.2026 | 0.0017 | 0.0017 | 0.0067 | 0.0274 | 0.1016 | 0.1496 | 0.1111 | 0.1407 | 0.4595 | 58 | 75 | 93 | 117 | 144 | 179 | 227 | 297 | 404 | 0.0022 | 69.15 | 6.693 | 0.2400 | 56286.8 | 22200000 | 10500000000 | 5560000000000 | 0.5618 | 0.1030 | 0.0253 | 0.0040 | 0.1149 | 0.0127 | 0.2821 | 0.0573 | 0.1909 | 0.1131 | 0.1740 | 0.1863 | 0.1166 | 0.2126 | 0.0439 | 0.1242 | 0.0389 | 0.1449 | 0.0135 | 0.1449 | 0.0006 | 0.0019 | 0.0025 | 0.0029 | 0.0125 | 0.0058 | 0.0368 | 0.0277 | 0.1085 | 0.0893 | 0.1696 | 0.1422 | 0.1103 | 0.1053 | 0.1490 | 0.1465 | 0.4102 | 0.4784 | 0.0049 | 0.0037 | 0.0069 | 0.0075 | 0.0208 | 0.0298 | 0.0573 | 0.0658 | 0.1285 | 0.1466 | 0.1887 | 0.1814 | 0.1176 | 0.1379 | 0.1542 | 0.1466 | 0.3211 | 0.2807 | 0.0016 | 0.0071 | 0.0158 | 0.0434 | 0.1278 | 0.1838 | 0.1112 | 0.1546 | 0.3549 |
| BT-20 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 646 | 630 | | 4918 | 16500 | 250.8 | 54.45 | 183.21 | 159.38 | 187 | 204 | 216 | 230 | 243 | 258 | 275 | 294 | 325 | 0.0553 | 912 | 1.082 | 114.59 | 36.69 | 1 | 0.0567 | 279 | 0.0010 | 47.80 | 7.180 | 0.1740 | 65866.1 | 18100000 | 5220000000 | 1580000000000 | 0.3928 | 0.2565 | 0.0000 | 0.0000 | 0.0009 | 0.0000 | 0.0047 | 0.0000 | 0.0187 | 0.0019 | 0.0548 | 0.0194 | 0.1246 | 0.0446 | 0.1390 | 0.0381 | 0.1798 | 0.0538 | 0.4774 | 0.8422 | 0.0000 | 0.0000 | 0.0007 | 0.0000 | 0.0010 | 0.0000 | 0.0081 | 0.0010 | 0.0259 | 0.0120 | 0.0548 | 0.0269 | 0.0577 | 0.0141 | 0.0883 | 0.0210 | 0.7634 | 0.9249 | 0.0059 | 0.0039 | 0.0012 | 0.0116 | 0.0190 | 0.0814 | 0.0853 | 0.1357 | 0.1291 | 0.1667 | 0.1623 | 0.1744 | 0.1232 | 0.1202 | 0.1374 | 0.1279 | 0.3365 | 0.1783 | 0.0009 | 0.0023 | 0.0064 | 0.0273 | 0.0792 | 0.1152 | 0.1184 | 0.1211 | 0.5291 | 18 | 33 | 60 | 103 | 150 | 198 | 247 | 309 | 400 | 0.0089 | 24.20 | 6.264 | 0.3693 | 58965.6 | 24900000 | 12800000000 | 7660000000000 | 0.5028 | 0.1524 | 0.0298 | 0.0012 | 0.1446 | 0.0060 | 0.2626 | 0.0670 | 0.1569 | 0.1200 | 0.1430 | 0.1772 | 0.1184 | 0.1974 | 0.0763 | 0.1242 | 0.0453 | 0.1282 | 0.0230 | 0.1788 | 0.0001 | 0.0000 | 0.0006 | 0.0004 | 0.0025 | 0.0008 | 0.0117 | 0.0094 | 0.0594 | 0.0454 | 0.1105 | 0.0804 | 0.0780 | 0.0631 | 0.1181 | 0.0977 | 0.6190 | 0.7028 | 0.0007 | 0.0013 | 0.0026 | 0.0028 | 0.0058 | 0.0118 | 0.0286 | 0.0350 | 0.0883 | 0.1071 | 0.1510 | 0.1803 | 0.1152 | 0.1150 | 0.1405 | 0.1436 | 0.4674 | 0.4032 | 0.0003 | 0.0018 | 0.0020 | 0.0202 | 0.0756 | 0.1282 | 0.0992 | 0.1368 | 0.5359 |
| MCF7 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 508 | 133 | | 5112 | 15953 | 596.9 | 122.93 | 209.99 | 332.25 | 447 | 490 | 521 | 552 | 585 | 617 | 653 | 698 | 767 | 0.0564 | 899 | 0.855 | 86.15 | 24.76 | 1 | 0.0428 | 219 | 0.0004 | 156.57 | 7.925 | 0.1053 | 371349.0 | 241000000 | 162000000000 | 113000000000000 | 0.4423 | 0.2051 | 0.0003 | 0.0000 | 0.0006 | 0.0000 | 0.0024 | 0.0000 | 0.0187 | 0.0008 | 0.0672 | 0.0192 | 0.1466 | 0.0410 | 0.1398 | 0.0373 | 0.1694 | 0.0551 | 0.4551 | 0.8466 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0089 | 0.0004 | 0.0325 | 0.0132 | 0.0678 | 0.0246 | 0.0610 | 0.0151 | 0.0909 | 0.0305 | 0.7386 | 0.9162 | 0.0023 | 0.0043 | 0.0103 | 0.0043 | 0.0195 | 0.0468 | 0.0736 | 0.1319 | 0.1310 | 0.1872 | 0.2080 | 0.2468 | 0.1023 | 0.0936 | 0.1264 | 0.1106 | 0.3264 | 0.1745 | 0.0008 | 0.0025 | 0.0105 | 0.0257 | 0.0758 | 0.1281 | 0.1049 | 0.1184 | 0.5333 | 8 | 10 | 12 | 14 | 20 | 73 | 208 | 417 | 696 | 0.1770 | 37.47 | 4.561 | 0.5961 | 154477.0 | 156000000 | 189000000000 | 260000000000000 | 0.5567 | 0.1171 | 0.0435 | 0.0017 | 0.1317 | 0.0133 | 0.1719 | 0.0920 | 0.1462 | 0.1123 | 0.1551 | 0.1516 | 0.1272 | 0.1707 | 0.1071 | 0.1244 | 0.0737 | 0.1291 | 0.0435 | 0.2049 | 0.0000 | 0.0003 | 0.0002 | 0.0000 | 0.0013 | 0.0010 | 0.0089 | 0.0045 | 0.0312 | 0.0322 | 0.0618 | 0.0501 | 0.0532 | 0.0353 | 0.0709 | 0.0694 | 0.7724 | 0.8070 | 0.0005 | 0.0002 | 0.0000 | 0.0007 | 0.0023 | 0.0015 | 0.0087 | 0.0100 | 0.0449 | 0.0500 | 0.0795 | 0.0826 | 0.0525 | 0.0585 | 0.0887 | 0.0933 | 0.7230 | 0.7032 | 0.0008 | 0.0015 | 0.0023 | 0.0088 | 0.0390 | 0.0736 | 0.0524 | 0.0793 | 0.7423 |
| MDA-MB-231 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 187 | 499 | | 5159 | 11813 | 530.2 | 150.73 | 46.53 | 99.31 | 336 | 405 | 473 | 515 | 555 | 600 | 635 | 664 | 696 | 0.0781 | 923 | 1.105 | 73.82 | 25.55 | 4 | 0.0382 | 197 | 0.0006 | 44.92 | 7.570 | 0.1925 | 303806.0 | 182000000 | 112000000000 | 70800000000000 | 0.3690 | 0.2568 | 0.0020 | 0.0000 | 0.0029 | 0.0000 | 0.0069 | 0.0004 | 0.0167 | 0.0024 | 0.0587 | 0.0163 | 0.0953 | 0.0308 | 0.0843 | 0.0238 | 0.1059 | 0.0400 | 0.6273 | 0.8863 | 0.0005 | 0.0000 | 0.0002 | 0.0000 | 0.0007 | 0.0000 | 0.0025 | 0.0021 | 0.0185 | 0.0146 | 0.0285 | 0.0275 | 0.0217 | 0.0173 | 0.0307 | 0.0266 | 0.8966 | 0.9119 | 0.0019 | 0.0635 | 0.0052 | 0.0476 | 0.0110 | 0.1270 | 0.0213 | 0.1429 | 0.0549 | 0.0635 | 0.0614 | 0.1270 | 0.0627 | 0.0952 | 0.1008 | 0.1270 | 0.6807 | 0.2063 | 0.0010 | 0.0024 | 0.0038 | 0.0076 | 0.0244 | 0.0344 | 0.0337 | 0.0485 | 0.8443 | 6 | 8 | 9 | 10 | 11 | 13 | 17 | 52 | 137 | 0.1781 | 7.69 | 3.150 | 0.7073 | 12026.7 | 6360000 | 4770000000 | 4300000000000 | 0.4827 | 0.1912 | 0.0208 | 0.0043 | 0.0655 | 0.0157 | 0.1042 | 0.0386 | 0.1548 | 0.0815 | 0.1935 | 0.1302 | 0.1905 | 0.1774 | 0.1488 | 0.1245 | 0.0893 | 0.1660 | 0.0327 | 0.2618 | 0.0004 | 0.0007 | 0.0004 | 0.0018 | 0.0011 | 0.0036 | 0.0042 | 0.0075 | 0.0229 | 0.0220 | 0.0362 | 0.0341 | 0.0320 | 0.0242 | 0.0526 | 0.0512 | 0.8502 | 0.8550 | 0.0000 | 0.0000 | 0.0022 | 0.0019 | 0.0044 | 0.0033 | 0.0079 | 0.0071 | 0.0271 | 0.0288 | 0.0411 | 0.0506 | 0.0389 | 0.0378 | 0.0599 | 0.0624 | 0.8186 | 0.8080 | 0.0000 | 0.0012 | 0.0032 | 0.0085 | 0.0263 | 0.0388 | 0.0324 | 0.0599 | 0.8297 |
| MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 394 | 413 | | 10632 | 28722 | 169.7 | 54.58 | 192.66 | 182.13 | 104 | 123 | 136 | 150 | 164 | 180 | 197 | 216 | 243 | 0.0521 | 1497 | 0.576 | 118.81 | 23.02 | 3 | 0.0271 | 288 | 0.0008 | 43.75 | 7.350 | 0.1857 | 31777.4 | 6480000 | 1420000000 | 333000000000 | 0.4827 | 0.1836 | 0.0013 | 0.0000 | 0.0034 | 0.0005 | 0.0185 | 0.0025 | 0.0583 | 0.0094 | 0.1357 | 0.0376 | 0.2026 | 0.0859 | 0.1755 | 0.0911 | 0.1662 | 0.1246 | 0.2386 | 0.6485 | 0.0005 | 0.0000 | 0.0011 | 0.0000 | 0.0027 | 0.0009 | 0.0142 | 0.0049 | 0.0416 | 0.0211 | 0.0761 | 0.0422 | 0.0667 | 0.0367 | 0.0911 | 0.0553 | 0.7060 | 0.8389 | 0.0022 | 0.0080 | 0.0032 | 0.0048 | 0.0097 | 0.0177 | 0.0479 | 0.1054 | 0.1186 | 0.1826 | 0.1586 | 0.1955 | 0.1287 | 0.1086 | 0.1536 | 0.1561 | 0.3774 | 0.2212 | 0.0008 | 0.0036 | 0.0069 | 0.0223 | 0.0674 | 0.1032 | 0.0931 | 0.1210 | 0.5817 | 24 | 38 | 60 | 93 | 133 | 183 | 247 | 329 | 451 | 0.0090 | 53.03 | 6.503 | 0.3348 | 70288.5 | 35100000 | 21300000000 | 14900000000000 | 0.4473 | 0.2023 | 0.0513 | 0.0009 | 0.1890 | 0.0115 | 0.2553 | 0.1069 | 0.1609 | 0.1443 | 0.1281 | 0.1866 | 0.0945 | 0.1921 | 0.0604 | 0.1246 | 0.0377 | 0.1011 | 0.0229 | 0.1320 | 0.0004 | 0.0002 | 0.0008 | 0.0006 | 0.0033 | 0.0030 | 0.0171 | 0.0128 | 0.0759 | 0.0579 | 0.1188 | 0.0951 | 0.0890 | 0.0750 | 0.1298 | 0.1102 | 0.5649 | 0.6452 | 0.0008 | 0.0009 | 0.0019 | 0.0028 | 0.0069 | 0.0116 | 0.0329 | 0.0449 | 0.1100 | 0.1226 | 0.1619 | 0.1747 | 0.1106 | 0.1143 | 0.1454 | 0.1490 | 0.4295 | 0.3791 | 0.0003 | 0.0015 | 0.0048 | 0.0246 | 0.0931 | 0.1422 | 0.1029 | 0.1420 | 0.4886 |
| Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 956 | 481 | | 1986 | 9878 | 45.3 | 11.48 | 35.21 | 55.46 | 30 | 34 | 39 | 42 | 45 | 48 | 51 | 56 | 60 | 0.0765 | 756 | 0.806 | 36.77 | 10.44 | 2 | 0.0539 | 107 | 0.0083 | 3.62 | 5.056 | 0.4649 | 2186.4 | 111365 | 5950000 | 331000000 | 0.4003 | 0.2238 | 0.0019 | 0.0000 | 0.0028 | 0.0011 | 0.0131 | 0.0045 | 0.0327 | 0.0129 | 0.0515 | 0.0286 | 0.0776 | 0.0432 | 0.1132 | 0.0510 | 0.1506 | 0.0875 | 0.5566 | 0.7712 | 0.0006 | 0.0000 | 0.0006 | 0.0000 | 0.0039 | 0.0021 | 0.0129 | 0.0078 | 0.0207 | 0.0204 | 0.0311 | 0.0266 | 0.0317 | 0.0282 | 0.0498 | 0.0408 | 0.8485 | 0.8741 | 0.0084 | 0.0229 | 0.0231 | 0.0458 | 0.0231 | 0.1069 | 0.0273 | 0.0992 | 0.0588 | 0.0840 | 0.0546 | 0.0992 | 0.0777 | 0.1603 | 0.1387 | 0.1221 | 0.5882 | 0.2595 | 0.0019 | 0.0058 | 0.0145 | 0.0270 | 0.0462 | 0.0568 | 0.0751 | 0.0934 | 0.6792 | 12 | 14 | 15 | 16 | 18 | 22 | 28 | 39 | 66 | 0.3765 | 2.00 | 2.023 | 0.8544 | 4314.9 | 1380000 | 642000000 | 351000000000 | 0.5769 | 0.1123 | 0.0338 | 0.0176 | 0.0938 | 0.0290 | 0.1429 | 0.0522 | 0.1420 | 0.0746 | 0.1488 | 0.1228 | 0.1505 | 0.1485 | 0.1234 | 0.1246 | 0.1023 | 0.1456 | 0.0626 | 0.2849 | 0.0033 | 0.0112 | 0.0063 | 0.0160 | 0.0139 | 0.0227 | 0.0325 | 0.0284 | 0.0634 | 0.0516 | 0.0933 | 0.0672 | 0.0863 | 0.0700 | 0.1218 | 0.1011 | 0.5792 | 0.6317 | 0.0016 | 0.0048 | 0.0055 | 0.0068 | 0.0131 | 0.0109 | 0.0344 | 0.0505 | 0.1071 | 0.1038 | 0.1301 | 0.1633 | 0.0945 | 0.1004 | 0.1519 | 0.1346 | 0.4617 | 0.4249 | 0.0047 | 0.0060 | 0.0125 | 0.0324 | 0.0824 | 0.1100 | 0.0846 | 0.1342 | 0.5332 |
| MCF7 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 867 | 303 | | 10525 | 22981 | 333.0 | 84.66 | 45.37 | 75.81 | 231 | 262 | 284 | 304 | 324 | 345 | 370 | 402 | 446 | 0.0579 | 1331 | 1.194 | 105.93 | 40.01 | 1 | 0.0257 | 270 | 0.0010 | 40.07 | 7.236 | 0.1890 | 118076.0 | 44400000 | 17700000000 | 7450000000000 | 0.4260 | 0.2189 | 0.0000 | 0.0001 | 0.0015 | 0.0003 | 0.0068 | 0.0012 | 0.0239 | 0.0034 | 0.0753 | 0.0228 | 0.1568 | 0.0533 | 0.1354 | 0.0528 | 0.1654 | 0.0744 | 0.4350 | 0.7917 | 0.0000 | 0.0000 | 0.0006 | 0.0003 | 0.0019 | 0.0008 | 0.0075 | 0.0014 | 0.0295 | 0.0128 | 0.0677 | 0.0308 | 0.0526 | 0.0219 | 0.0734 | 0.0339 | 0.7667 | 0.8981 | 0.0023 | 0.0026 | 0.0037 | 0.0052 | 0.0130 | 0.0324 | 0.0570 | 0.0999 | 0.1178 | 0.1829 | 0.1817 | 0.1971 | 0.1201 | 0.1180 | 0.1266 | 0.1621 | 0.3778 | 0.1997 | 0.0010 | 0.0017 | 0.0075 | 0.0252 | 0.0647 | 0.1221 | 0.0967 | 0.1131 | 0.5681 | 4 | 6 | 7 | 8 | 9 | 11 | 28 | 73 | 154 | 0.2117 | 3.47 | 3.149 | 0.6748 | 7805.6 | 1970000 | 596000000 | 207000000000 | 0.5167 | 0.1279 | 0.0456 | 0.0020 | 0.1917 | 0.0224 | 0.2767 | 0.1079 | 0.1710 | 0.1649 | 0.1078 | 0.1863 | 0.0870 | 0.1802 | 0.0508 | 0.1247 | 0.0497 | 0.0982 | 0.0197 | 0.1135 | 0.0000 | 0.0000 | 0.0006 | 0.0011 | 0.0017 | 0.0017 | 0.0086 | 0.0095 | 0.0396 | 0.0289 | 0.0677 | 0.0646 | 0.0470 | 0.0441 | 0.0664 | 0.0586 | 0.7684 | 0.7915 | 0.0002 | 0.0000 | 0.0004 | 0.0012 | 0.0028 | 0.0030 | 0.0103 | 0.0134 | 0.0476 | 0.0496 | 0.0803 | 0.0866 | 0.0509 | 0.0552 | 0.0806 | 0.0824 | 0.7269 | 0.7085 | 0.0000 | 0.0003 | 0.0020 | 0.0099 | 0.0440 | 0.0719 | 0.0541 | 0.0710 | 0.7467 |
| MDA-MB-231 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 308 | 884 | | 5050 | 10182 | 749.7 | 126.97 | 42.65 | 71.54 | 594 | 652 | 686 | 713 | 737 | 762 | 805 | 871 | 942 | 0.0693 | 706 | 1.198 | 99.81 | 37.54 | 1 | 0.0493 | 249 | 0.0009 | 44.07 | 7.331 | 0.2040 | 578151.0 | 458000000 | 371000000000 | 308000000000000 | 0.4226 | 0.2196 | 0.0003 | 0.0000 | 0.0008 | 0.0000 | 0.0027 | 0.0000 | 0.0068 | 0.0006 | 0.0285 | 0.0120 | 0.0415 | 0.0212 | 0.0388 | 0.0132 | 0.0616 | 0.0186 | 0.8190 | 0.9345 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0004 | 0.0000 | 0.0020 | 0.0006 | 0.0159 | 0.0120 | 0.0237 | 0.0212 | 0.0190 | 0.0116 | 0.0326 | 0.0178 | 0.9061 | 0.9369 | 0.0036 | 0.0000 | 0.0000 | 0.0000 | 0.0024 | 0.0000 | 0.0169 | 1.0000 | 0.0495 | 0.0000 | 0.0579 | 0.0000 | 0.0760 | 0.0000 | 0.0893 | 0.0000 | 0.7045 | 0.0000 | 0.0027 | 0.0054 | 0.0125 | 0.0152 | 0.0411 | 0.0438 | 0.0585 | 0.0688 | 0.7520 | 6 | 8 | 9 | 11 | 13 | 19 | 36 | 60 | 109 | 0.1640 | 2.95 | 2.935 | 0.7102 | 6935.9 | 2170000 | 941000000 | 501000000000 | 0.4404 | 0.1899 | 0.0194 | 0.0075 | 0.0535 | 0.0125 | 0.1069 | 0.0337 | 0.1470 | 0.0580 | 0.1701 | 0.1079 | 0.1750 | 0.1341 | 0.1665 | 0.1248 | 0.1130 | 0.1622 | 0.0486 | 0.3593 | 0.0013 | 0.0014 | 0.0041 | 0.0022 | 0.0048 | 0.0064 | 0.0153 | 0.0160 | 0.0396 | 0.0329 | 0.0616 | 0.0440 | 0.0517 | 0.0442 | 0.0727 | 0.0650 | 0.7490 | 0.7879 | 0.0017 | 0.0020 | 0.0043 | 0.0035 | 0.0108 | 0.0055 | 0.0208 | 0.0179 | 0.0554 | 0.0546 | 0.0705 | 0.0789 | 0.0575 | 0.0645 | 0.0809 | 0.0904 | 0.6981 | 0.6827 | 0.0015 | 0.0037 | 0.0104 | 0.0186 | 0.0443 | 0.0707 | 0.0592 | 0.0878 | 0.7039 | ||
| BT-20 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 1142 | 279 | | 6081 | 12680 | 333.3 | 75.05 | 132.72 | 150.99 | 244 | 268 | 287 | 305 | 325 | 343 | 366 | 393 | 433 | 0.0758 | 961 | 1.101 | 113.36 | 37.12 | 1 | 0.0462 | 281 | 0.0013 | 26.51 | 6.910 | 0.2088 | 116744.0 | 43000000 | 16600000000 | 6710000000000 | 0.3801 | 0.2654 | 0.0005 | 0.0000 | 0.0021 | 0.0000 | 0.0042 | 0.0000 | 0.0168 | 0.0011 | 0.0633 | 0.0200 | 0.1116 | 0.0341 | 0.1355 | 0.0320 | 0.1721 | 0.0541 | 0.4938 | 0.8587 | 0.0004 | 0.0000 | 0.0010 | 0.0000 | 0.0020 | 0.0000 | 0.0071 | 0.0005 | 0.0310 | 0.0141 | 0.0482 | 0.0230 | 0.0586 | 0.0181 | 0.0796 | 0.0318 | 0.7721 | 0.9125 | 0.0037 | 0.0088 | 0.0119 | 0.0117 | 0.0165 | 0.0263 | 0.0567 | 0.0380 | 0.1033 | 0.1082 | 0.1435 | 0.1345 | 0.1060 | 0.0936 | 0.1389 | 0.1082 | 0.4196 | 0.4708 | 0.0018 | 0.0043 | 0.0093 | 0.0205 | 0.0751 | 0.1053 | 0.0830 | 0.1165 | 0.5841 | 10 | 15 | 26 | 48 | 77 | 111 | 158 | 228 | 346 | 0.0156 | 26.28 | 5.931 | 0.4048 | 40411.4 | 17400000 | 9060000000 | 5290000000000 | 0.5025 | 0.1413 | 0.0228 | 0.0017 | 0.0773 | 0.0063 | 0.1471 | 0.0370 | 0.1547 | 0.0783 | 0.1747 | 0.1540 | 0.1485 | 0.1778 | 0.1105 | 0.1249 | 0.0905 | 0.1378 | 0.0739 | 0.2822 | 0.0000 | 0.0006 | 0.0013 | 0.0013 | 0.0013 | 0.0021 | 0.0136 | 0.0091 | 0.0417 | 0.0414 | 0.0724 | 0.0662 | 0.0582 | 0.0462 | 0.0751 | 0.0721 | 0.7364 | 0.7610 | 0.0003 | 0.0006 | 0.0021 | 0.0031 | 0.0040 | 0.0037 | 0.0143 | 0.0131 | 0.0562 | 0.0601 | 0.0816 | 0.1055 | 0.0776 | 0.0812 | 0.1052 | 0.1173 | 0.6588 | 0.6153 | 0.0014 | 0.0020 | 0.0034 | 0.0108 | 0.0473 | 0.0756 | 0.0567 | 0.0882 | 0.7146 | ||
| SK-BR-3 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 1218 | 913 | | 1758 | 2499 | 60.5 | 14.09 | 168.06 | 202.27 | 37 | 49 | 56 | 60 | 64 | 66 | 69 | 72 | 76 | 0.1709 | 427 | 1.246 | 80.75 | 28.65 | 1 | 0.1115 | 196 | 0.0648 | 0.70 | 3.033 | 0.7245 | 3855.7 | 255103 | 17300000 | 1200000000 | 0.4086 | 0.2272 | 0.0020 | 0.0000 | 0.0127 | 0.0000 | 0.0402 | 0.0057 | 0.0412 | 0.0076 | 0.0794 | 0.0264 | 0.1039 | 0.0415 | 0.1265 | 0.0447 | 0.1657 | 0.0730 | 0.4284 | 0.8011 | 0.0000 | 0.0000 | 0.0021 | 0.0000 | 0.0035 | 0.0056 | 0.0064 | 0.0062 | 0.0275 | 0.0249 | 0.0346 | 0.0386 | 0.0388 | 0.0311 | 0.0473 | 0.0398 | 0.8397 | 0.8538 | 0.0101 | 0.3889 | 0.0455 | 0.1667 | 0.0758 | 0.3889 | 0.0934 | 0.0556 | 0.1641 | 0.0000 | 0.1919 | 0.0000 | 0.1490 | 0.0000 | 0.1086 | 0.0000 | 0.1616 | 0.0000 | 0.0000 | 0.0036 | 0.0073 | 0.0255 | 0.0473 | 0.0673 | 0.1092 | 0.1583 | 0.5814 | 4 | 6 | 7 | 11 | 74 | 155 | 243 | 343 | 479 | 0.0246 | 19.24 | 4.564 | 0.3199 | 69139.4 | 35300000 | 20400000000 | 12900000000000 | 0.3902 | 0.2388 | 0.0270 | 0.0023 | 0.0991 | 0.0070 | 0.2748 | 0.0651 | 0.1802 | 0.1256 | 0.1036 | 0.1419 | 0.0856 | 0.2186 | 0.0901 | 0.1256 | 0.0676 | 0.0814 | 0.0721 | 0.2326 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0028 | 0.0025 | 0.0102 | 0.0076 | 0.0361 | 0.0352 | 0.0981 | 0.0730 | 0.0796 | 0.0554 | 0.0907 | 0.0671 | 0.6824 | 0.7592 | 0.0000 | 0.0013 | 0.0000 | 0.0039 | 0.0012 | 0.0066 | 0.0210 | 0.0197 | 0.0723 | 0.0748 | 0.1142 | 0.1391 | 0.1037 | 0.1063 | 0.1224 | 0.1299 | 0.5653 | 0.5184 | 0.0000 | 0.0031 | 0.0031 | 0.0084 | 0.0670 | 0.0974 | 0.0827 | 0.1068 | 0.6314 | ||
| Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 420 | 407 | | 25302 | 42176 | 171.8 | 49.38 | 147.43 | 237.23 | 112 | 132 | 146 | 157 | 168 | 180 | 193 | 209 | 237 | 0.0462 | 1948 | 0.760 | 83.49 | 25.63 | 2 | 0.0098 | 247 | 0.0005 | 62.65 | 7.913 | 0.1534 | 31965.7 | 6390000 | 1360000000 | 309000000000 | 0.4638 | 0.1892 | 0.0006 | 0.0001 | 0.0017 | 0.0002 | 0.0040 | 0.0010 | 0.0225 | 0.0052 | 0.0688 | 0.0183 | 0.1379 | 0.0386 | 0.1421 | 0.0455 | 0.1734 | 0.0654 | 0.4489 | 0.8256 | 0.0003 | 0.0000 | 0.0009 | 0.0001 | 0.0012 | 0.0003 | 0.0082 | 0.0023 | 0.0254 | 0.0102 | 0.0549 | 0.0202 | 0.0570 | 0.0218 | 0.0776 | 0.0313 | 0.7745 | 0.9136 | 0.0031 | 0.0052 | 0.0063 | 0.0083 | 0.0203 | 0.0270 | 0.0520 | 0.0513 | 0.0941 | 0.0896 | 0.1249 | 0.1265 | 0.0922 | 0.0926 | 0.1087 | 0.1087 | 0.4984 | 0.4909 | 0.0012 | 0.0029 | 0.0075 | 0.0285 | 0.0609 | 0.0972 | 0.0953 | 0.1135 | 0.5931 | 15 | 18 | 20 | 25 | 35 | 63 | 116 | 226 | 460 | 0.1298 | 9.91 | 4.162 | 0.6635 | 78010.9 | 64000000 | 64700000000 | 75200000000000 | 0.5804 | 0.1109 | 0.0461 | 0.0048 | 0.1404 | 0.0150 | 0.1993 | 0.0735 | 0.1444 | 0.1068 | 0.1579 | 0.1632 | 0.1301 | 0.1918 | 0.0879 | 0.1258 | 0.0525 | 0.1221 | 0.0414 | 0.1970 | 0.0003 | 0.0004 | 0.0022 | 0.0006 | 0.0037 | 0.0016 | 0.0126 | 0.0129 | 0.0488 | 0.0445 | 0.0771 | 0.0675 | 0.0547 | 0.0498 | 0.0753 | 0.0744 | 0.7252 | 0.7484 | 0.0003 | 0.0004 | 0.0020 | 0.0030 | 0.0029 | 0.0043 | 0.0165 | 0.0197 | 0.0624 | 0.0647 | 0.0891 | 0.0998 | 0.0647 | 0.0673 | 0.0892 | 0.0949 | 0.6728 | 0.6458 | 0.0008 | 0.0012 | 0.0033 | 0.0140 | 0.0563 | 0.0848 | 0.0591 | 0.0848 | 0.6958 |
| MDA-MB-231 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 900 | 171 | | 3930 | 11298 | 497.7 | 103.96 | 94.40 | 173.19 | 316 | 409 | 476 | 500 | 521 | 540 | 560 | 583 | 613 | 0.0641 | 724 | 0.847 | 112.54 | 33.02 | 4 | 0.0832 | 327 | 0.0011 | 32.58 | 7.096 | 0.2211 | 258499.0 | 139000000 | 76000000000 | 42400000000000 | 0.3874 | 0.2511 | 0.0008 | 0.0003 | 0.0015 | 0.0000 | 0.0057 | 0.0000 | 0.0069 | 0.0008 | 0.0413 | 0.0186 | 0.0462 | 0.0251 | 0.0569 | 0.0178 | 0.0810 | 0.0276 | 0.7597 | 0.9099 | 0.0000 | 0.0003 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0003 | 0.0008 | 0.0197 | 0.0186 | 0.0188 | 0.0251 | 0.0172 | 0.0178 | 0.0260 | 0.0276 | 0.9179 | 0.9099 | 0.0052 | 0.0000 | 0.0140 | 0.0000 | 0.0315 | 0.0000 | 0.0542 | 0.0000 | 0.0717 | 0.0000 | 0.0944 | 0.0000 | 0.1119 | 0.0000 | 0.1556 | 0.0000 | 0.4615 | 0.0000 | 0.0012 | 0.0042 | 0.0037 | 0.0108 | 0.0279 | 0.0396 | 0.0500 | 0.0629 | 0.7997 | 6 | 7 | 9 | 10 | 14 | 24 | 52 | 125 | 339 | 0.1266 | 21.37 | 4.235 | 0.6154 | 38902.8 | 22700000 | 15400000000 | 11500000000000 | 0.5106 | 0.1373 | 0.0416 | 0.0018 | 0.1323 | 0.0210 | 0.2420 | 0.0602 | 0.1739 | 0.1267 | 0.1815 | 0.2124 | 0.1361 | 0.2042 | 0.0586 | 0.1258 | 0.0265 | 0.1167 | 0.0076 | 0.1313 | 0.0000 | 0.0003 | 0.0003 | 0.0009 | 0.0031 | 0.0015 | 0.0097 | 0.0106 | 0.0497 | 0.0439 | 0.0660 | 0.0569 | 0.0453 | 0.0375 | 0.0729 | 0.0623 | 0.7530 | 0.7860 | 0.0000 | 0.0000 | 0.0008 | 0.0000 | 0.0013 | 0.0018 | 0.0139 | 0.0172 | 0.0499 | 0.0548 | 0.0820 | 0.0743 | 0.0465 | 0.0535 | 0.0714 | 0.0729 | 0.7342 | 0.7254 | 0.0008 | 0.0000 | 0.0015 | 0.0131 | 0.0528 | 0.0670 | 0.0466 | 0.0751 | 0.7432 |
| MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1219 | 611 | | 6727 | 10795 | 500.4 | 87.18 | 61.57 | 164.61 | 389 | 436 | 464 | 484 | 500 | 519 | 539 | 564 | 613 | 0.0766 | 827 | 0.887 | 151.21 | 35.90 | 4 | 0.0523 | 352 | 0.0010 | 40.11 | 7.197 | 0.1973 | 258004.0 | 137000000 | 74100000000 | 41200000000000 | 0.4599 | 0.1961 | 0.0006 | 0.0000 | 0.0008 | 0.0000 | 0.0006 | 0.0000 | 0.0061 | 0.0005 | 0.0334 | 0.0138 | 0.0743 | 0.0305 | 0.0688 | 0.0200 | 0.0981 | 0.0361 | 0.7174 | 0.8992 | 0.0003 | 0.0000 | 0.0003 | 0.0000 | 0.0002 | 0.0000 | 0.0020 | 0.0002 | 0.0203 | 0.0122 | 0.0431 | 0.0268 | 0.0321 | 0.0141 | 0.0475 | 0.0242 | 0.8540 | 0.9226 | 0.0036 | 0.0385 | 0.0109 | 0.0641 | 0.0243 | 0.0256 | 0.0510 | 0.1282 | 0.0875 | 0.2179 | 0.1179 | 0.2179 | 0.0899 | 0.1026 | 0.1118 | 0.1026 | 0.5030 | 0.1026 | 0.0015 | 0.0026 | 0.0100 | 0.0280 | 0.0665 | 0.1130 | 0.0971 | 0.1266 | 0.5546 | 5 | 5 | 7 | 8 | 9 | 10 | 12 | 20 | 145 | 0.3474 | 14.59 | 2.480 | 0.7590 | 30885.0 | 22100000 | 18100000000 | 16500000000000 | 0.6221 | 0.0747 | 0.0404 | 0.0026 | 0.1515 | 0.0289 | 0.2172 | 0.0525 | 0.2071 | 0.1732 | 0.1515 | 0.2310 | 0.1414 | 0.2047 | 0.0505 | 0.1260 | 0.0303 | 0.0866 | 0.0101 | 0.0945 | 0.0000 | 0.0006 | 0.0006 | 0.0030 | 0.0032 | 0.0024 | 0.0121 | 0.0119 | 0.0401 | 0.0351 | 0.0650 | 0.0660 | 0.0510 | 0.0463 | 0.0643 | 0.0564 | 0.7637 | 0.7784 | 0.0000 | 0.0000 | 0.0015 | 0.0015 | 0.0015 | 0.0038 | 0.0175 | 0.0215 | 0.0445 | 0.0445 | 0.0729 | 0.0722 | 0.0590 | 0.0507 | 0.0649 | 0.0753 | 0.7383 | 0.7304 | 0.0000 | 0.0014 | 0.0020 | 0.0143 | 0.0442 | 0.0626 | 0.0558 | 0.0721 | 0.7476 |
| BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 422 | 387 | | 8367 | 21686 | 338.6 | 51.23 | 216.62 | 253.93 | 275 | 292 | 307 | 321 | 337 | 351 | 367 | 383 | 406 | 0.0592 | 1284 | 1.224 | 118.07 | 44.69 | 1 | 0.0354 | 296 | 0.0016 | 21.25 | 6.715 | 0.2518 | 117279.0 | 41500000 | 15000000000 | 5540000000000 | 0.4429 | 0.2078 | 0.0001 | 0.0000 | 0.0004 | 0.0000 | 0.0013 | 0.0000 | 0.0080 | 0.0001 | 0.0305 | 0.0112 | 0.0543 | 0.0192 | 0.0664 | 0.0146 | 0.1150 | 0.0208 | 0.7238 | 0.9341 | 0.0001 | 0.0000 | 0.0003 | 0.0000 | 0.0005 | 0.0000 | 0.0034 | 0.0000 | 0.0155 | 0.0105 | 0.0264 | 0.0169 | 0.0305 | 0.0096 | 0.0535 | 0.0147 | 0.8698 | 0.9484 | 0.0147 | 0.0000 | 0.0209 | 0.0000 | 0.0466 | 0.0000 | 0.0798 | 0.0000 | 0.1325 | 0.0000 | 0.1509 | 0.0000 | 0.1166 | 0.0000 | 0.1387 | 0.0000 | 0.2994 | 0.0000 | 0.0029 | 0.0037 | 0.0079 | 0.0179 | 0.0489 | 0.0872 | 0.0769 | 0.1138 | 0.6407 | 23 | 31 | 44 | 65 | 97 | 158 | 256 | 389 | 599 | 0.0168 | 30.30 | 6.006 | 0.4494 | 111401.0 | 80200000 | 68700000000 | 66100000000000 | 0.5043 | 0.1472 | 0.0237 | 0.0026 | 0.1369 | 0.0072 | 0.2565 | 0.0574 | 0.1751 | 0.1186 | 0.1568 | 0.1945 | 0.1196 | 0.2092 | 0.0501 | 0.1261 | 0.0356 | 0.1132 | 0.0458 | 0.1711 | 0.0002 | 0.0003 | 0.0005 | 0.0006 | 0.0022 | 0.0014 | 0.0105 | 0.0091 | 0.0514 | 0.0447 | 0.0911 | 0.0790 | 0.0565 | 0.0498 | 0.0825 | 0.0754 | 0.7050 | 0.7396 | 0.0003 | 0.0002 | 0.0011 | 0.0016 | 0.0023 | 0.0053 | 0.0156 | 0.0192 | 0.0627 | 0.0685 | 0.1061 | 0.1174 | 0.0749 | 0.0819 | 0.0955 | 0.0997 | 0.6414 | 0.6062 | 0.0001 | 0.0003 | 0.0026 | 0.0142 | 0.0598 | 0.0932 | 0.0668 | 0.0874 | 0.6756 |
| Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 125 | 887 | | 914 | 10249 | 57.4 | 40.69 | 232.85 | 304.99 | 28 | 31 | 33 | 35 | 38 | 42 | 56 | 82 | 127 | 0.0631 | 647 | 1.229 | 27.66 | 9.43 | 1 | 0.0722 | 66 | 0.0076 | 22.99 | 5.445 | 0.3165 | 4951.9 | 588247 | 83100000 | 12800000000 | 0.3258 | 0.3035 | 0.0088 | 0.0152 | 0.0000 | 0.0127 | 0.0531 | 0.0482 | 0.1239 | 0.0736 | 0.3451 | 0.1624 | 0.2832 | 0.1574 | 0.1416 | 0.1650 | 0.0354 | 0.1421 | 0.0088 | 0.2234 | 0.0000 | 0.0103 | 0.0000 | 0.0086 | 0.0091 | 0.0325 | 0.0151 | 0.0462 | 0.0393 | 0.0856 | 0.0665 | 0.0805 | 0.0665 | 0.0702 | 0.0634 | 0.0771 | 0.7402 | 0.5890 | 0.0000 | 0.0053 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0046 | 0.0211 | 0.0826 | 0.0842 | 0.0872 | 0.0579 | 0.0459 | 0.0737 | 0.1101 | 0.0895 | 0.6697 | 0.6684 | 0.0000 | 0.0000 | 0.0037 | 0.0297 | 0.0409 | 0.0632 | 0.0743 | 0.0706 | 0.7175 | 22 | 26 | 32 | 50 | 83 | 141 | 256 | 424 | 686 | 0.0356 | 29.95 | 5.321 | 0.4926 | 147227.0 | 131000000 | 137000000000 | 161000000000000 | 0.6516 | 0.0660 | 0.0697 | 0.0026 | 0.1780 | 0.0222 | 0.2107 | 0.0941 | 0.1395 | 0.1359 | 0.1543 | 0.1737 | 0.1157 | 0.1966 | 0.0772 | 0.1261 | 0.0356 | 0.1261 | 0.0193 | 0.1228 | 0.0008 | 0.0002 | 0.0011 | 0.0012 | 0.0025 | 0.0051 | 0.0195 | 0.0177 | 0.0641 | 0.0572 | 0.0786 | 0.0824 | 0.0675 | 0.0545 | 0.0853 | 0.0863 | 0.6804 | 0.6953 | 0.0010 | 0.0015 | 0.0031 | 0.0035 | 0.0062 | 0.0073 | 0.0244 | 0.0289 | 0.0714 | 0.0763 | 0.0975 | 0.0960 | 0.0752 | 0.0867 | 0.0962 | 0.1044 | 0.6250 | 0.5954 | 0.0006 | 0.0012 | 0.0046 | 0.0178 | 0.0705 | 0.0911 | 0.0644 | 0.0929 | 0.6569 |
| MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 512 | 618 | | 11255 | 20255 | 428.2 | 87.05 | 105.63 | 203.30 | 309 | 354 | 384 | 408 | 429 | 449 | 474 | 501 | 549 | 0.0544 | 1102 | 0.683 | 111.73 | 25.46 | 6 | 0.0275 | 310 | 0.0009 | 22.99 | 7.263 | 0.2438 | 190902.0 | 88200000 | 42000000000 | 20600000000000 | 0.4424 | 0.2031 | 0.0003 | 0.0000 | 0.0008 | 0.0001 | 0.0026 | 0.0004 | 0.0084 | 0.0012 | 0.0280 | 0.0134 | 0.0584 | 0.0238 | 0.0474 | 0.0178 | 0.0713 | 0.0278 | 0.7829 | 0.9155 | 0.0001 | 0.0000 | 0.0003 | 0.0000 | 0.0008 | 0.0000 | 0.0033 | 0.0008 | 0.0135 | 0.0104 | 0.0281 | 0.0209 | 0.0204 | 0.0124 | 0.0313 | 0.0184 | 0.9022 | 0.9370 | 0.0011 | 0.0000 | 0.0063 | 0.0000 | 0.0110 | 0.0000 | 0.0226 | 0.0000 | 0.0479 | 0.0000 | 0.0805 | 0.0000 | 0.0642 | 0.0000 | 0.0789 | 0.0000 | 0.6875 | 0.0000 | 0.0009 | 0.0019 | 0.0058 | 0.0140 | 0.0333 | 0.0539 | 0.0552 | 0.0744 | 0.7606 | 8 | 9 | 10 | 11 | 13 | 16 | 42 | 145 | 378 | 0.0720 | 5.26 | 3.153 | 0.4465 | 52486.1 | 36900000 | 30400000000 | 27900000000000 | 0.5667 | 0.1091 | 0.0648 | 0.0042 | 0.2221 | 0.0305 | 0.2455 | 0.1491 | 0.1821 | 0.1574 | 0.1255 | 0.1533 | 0.0690 | 0.1678 | 0.0331 | 0.1262 | 0.0317 | 0.0846 | 0.0262 | 0.1269 | 0.0004 | 0.0000 | 0.0006 | 0.0006 | 0.0010 | 0.0017 | 0.0112 | 0.0092 | 0.0467 | 0.0430 | 0.0696 | 0.0628 | 0.0485 | 0.0415 | 0.0752 | 0.0685 | 0.7467 | 0.7729 | 0.0005 | 0.0005 | 0.0007 | 0.0007 | 0.0016 | 0.0025 | 0.0113 | 0.0152 | 0.0565 | 0.0539 | 0.0774 | 0.0786 | 0.0493 | 0.0607 | 0.0870 | 0.0851 | 0.7156 | 0.7027 | 0.0007 | 0.0000 | 0.0020 | 0.0119 | 0.0543 | 0.0701 | 0.0508 | 0.0795 | 0.7308 |