High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
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| Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
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| Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 438 | 881 | | 789 | 8063 | 74.1 | 31.85 | 47.97 | 131.71 | 30 | 40 | 55 | 65 | 73 | 81 | 92 | 101 | 116 | 0.0633 | 510 | 0.386 | 127.58 | 22.47 | 2 | 0.5982 | 472 | 0.0024 | 38.72 | 6.180 | 0.1858 | 6504.0 | 641928 | 68900000 | 7880000000 | 0.3632 | 0.2507 | 0.0000 | 0.0000 | 0.0038 | 0.0000 | 0.0538 | 0.0043 | 0.1000 | 0.0172 | 0.2115 | 0.0948 | 0.1808 | 0.1401 | 0.1846 | 0.1185 | 0.1692 | 0.1789 | 0.0962 | 0.4461 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0135 | 0.0049 | 0.0558 | 0.0395 | 0.0673 | 0.0543 | 0.0635 | 0.0329 | 0.0885 | 0.0625 | 0.7115 | 0.8059 | 0.0000 | 0.0000 | 0.0154 | 0.0139 | 0.0077 | 0.0625 | 0.0346 | 0.0694 | 0.0962 | 0.1319 | 0.1269 | 0.1667 | 0.1038 | 0.1528 | 0.1692 | 0.1250 | 0.4462 | 0.2778 | 0.0026 | 0.0000 | 0.0026 | 0.0179 | 0.0742 | 0.0818 | 0.1023 | 0.1560 | 0.5627 | 11 | 13 | 15 | 16 | 18 | 20 | 22 | 26 | 61 | 0.4823 | 4.88 | 1.769 | 0.8585 | 19647.5 | 17700000 | 20000000000 | 25500000000000 | 0.6771 | 0.1020 | 0.0533 | 0.0311 | 0.1557 | 0.0251 | 0.2172 | 0.0621 | 0.2377 | 0.0932 | 0.2008 | 0.1657 | 0.0820 | 0.2027 | 0.0287 | 0.1686 | 0.0164 | 0.1198 | 0.0082 | 0.1317 | 0.0000 | 0.0147 | 0.0009 | 0.0077 | 0.0046 | 0.0105 | 0.0352 | 0.0252 | 0.0897 | 0.0617 | 0.1175 | 0.0870 | 0.1027 | 0.1024 | 0.1036 | 0.1080 | 0.5458 | 0.5827 | 0.0012 | 0.0013 | 0.0036 | 0.0027 | 0.0060 | 0.0080 | 0.0239 | 0.0213 | 0.1004 | 0.1120 | 0.1470 | 0.1600 | 0.1016 | 0.0973 | 0.1147 | 0.1307 | 0.5018 | 0.4667 | 0.0000 | 0.0011 | 0.0074 | 0.0253 | 0.1077 | 0.1267 | 0.0940 | 0.1109 | 0.5269 |
| MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 831 | 627 | | 22430 | 35732 | 126.0 | 38.62 | 252.74 | 227.53 | 82 | 95 | 104 | 113 | 121 | 131 | 142 | 157 | 179 | 0.0532 | 1901 | 0.880 | 73.43 | 20.81 | 2 | 0.0089 | 200 | 0.0017 | 21.99 | 6.753 | 0.2609 | 17379.7 | 2600000 | 417000000 | 71800000000 | 0.4412 | 0.2102 | 0.0006 | 0.0001 | 0.0021 | 0.0002 | 0.0088 | 0.0011 | 0.0346 | 0.0052 | 0.1045 | 0.0291 | 0.1823 | 0.0693 | 0.1643 | 0.0693 | 0.1767 | 0.0997 | 0.3261 | 0.7259 | 0.0002 | 0.0001 | 0.0008 | 0.0001 | 0.0022 | 0.0002 | 0.0101 | 0.0018 | 0.0357 | 0.0141 | 0.0709 | 0.0319 | 0.0688 | 0.0258 | 0.0917 | 0.0432 | 0.7197 | 0.8826 | 0.0034 | 0.0054 | 0.0050 | 0.0100 | 0.0140 | 0.0284 | 0.0533 | 0.0888 | 0.0998 | 0.1568 | 0.1659 | 0.2106 | 0.1164 | 0.1172 | 0.1451 | 0.1426 | 0.3972 | 0.2402 | 0.0011 | 0.0034 | 0.0087 | 0.0271 | 0.0720 | 0.1160 | 0.1006 | 0.1196 | 0.5516 | 16 | 33 | 75 | 138 | 204 | 273 | 343 | 432 | 576 | 0.0082 | 55.93 | 6.842 | 0.3237 | 115644.0 | 68100000 | 47400000000 | 37300000000000 | 0.5184 | 0.1555 | 0.0294 | 0.0010 | 0.1132 | 0.0078 | 0.2146 | 0.0613 | 0.1758 | 0.0954 | 0.1640 | 0.1647 | 0.1397 | 0.1993 | 0.0852 | 0.1472 | 0.0476 | 0.1393 | 0.0304 | 0.1840 | 0.0000 | 0.0002 | 0.0006 | 0.0007 | 0.0018 | 0.0015 | 0.0125 | 0.0070 | 0.0472 | 0.0386 | 0.0990 | 0.0797 | 0.0795 | 0.0590 | 0.1063 | 0.0906 | 0.6532 | 0.7227 | 0.0006 | 0.0013 | 0.0027 | 0.0029 | 0.0077 | 0.0109 | 0.0241 | 0.0340 | 0.0806 | 0.1011 | 0.1356 | 0.1539 | 0.1094 | 0.1178 | 0.1359 | 0.1438 | 0.5033 | 0.4344 | 0.0003 | 0.0016 | 0.0049 | 0.0169 | 0.0624 | 0.1189 | 0.0930 | 0.1202 | 0.5819 |
| MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 595 | 443 | | 5995 | 10600 | 127.3 | 28.53 | 123.95 | 93.46 | 93 | 103 | 111 | 117 | 124 | 131 | 139 | 150 | 166 | 0.0878 | 931 | 1.110 | 107.91 | 35.51 | 1 | 0.0454 | 272 | 0.0024 | 17.97 | 6.317 | 0.2686 | 17011.3 | 2390000 | 351000000 | 54200000000 | 0.4279 | 0.2247 | 0.0003 | 0.0000 | 0.0016 | 0.0000 | 0.0081 | 0.0009 | 0.0256 | 0.0032 | 0.0811 | 0.0218 | 0.1460 | 0.0470 | 0.1630 | 0.0517 | 0.1863 | 0.0761 | 0.3880 | 0.7993 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0020 | 0.0003 | 0.0092 | 0.0008 | 0.0374 | 0.0147 | 0.0669 | 0.0251 | 0.0697 | 0.0229 | 0.0981 | 0.0354 | 0.7162 | 0.9007 | 0.0056 | 0.0116 | 0.0112 | 0.0462 | 0.0243 | 0.0520 | 0.1104 | 0.1185 | 0.1375 | 0.2110 | 0.1908 | 0.2052 | 0.1272 | 0.1098 | 0.1197 | 0.1214 | 0.2732 | 0.1243 | 0.0029 | 0.0029 | 0.0118 | 0.0319 | 0.0937 | 0.1342 | 0.1202 | 0.1461 | 0.4562 | 21 | 35 | 53 | 77 | 105 | 135 | 167 | 204 | 256 | 0.0045 | 24.94 | 6.421 | 0.3407 | 24096.0 | 5870000 | 1650000000 | 518000000000 | 0.4887 | 0.1638 | 0.0159 | 0.0014 | 0.0819 | 0.0078 | 0.2092 | 0.0351 | 0.1715 | 0.0762 | 0.1821 | 0.1512 | 0.1520 | 0.2185 | 0.0825 | 0.1455 | 0.0631 | 0.1599 | 0.0418 | 0.2044 | 0.0011 | 0.0006 | 0.0016 | 0.0008 | 0.0036 | 0.0029 | 0.0113 | 0.0087 | 0.0506 | 0.0382 | 0.0872 | 0.0805 | 0.0734 | 0.0558 | 0.1058 | 0.0924 | 0.6654 | 0.7202 | 0.0018 | 0.0020 | 0.0026 | 0.0030 | 0.0084 | 0.0100 | 0.0221 | 0.0341 | 0.0767 | 0.0955 | 0.1270 | 0.1543 | 0.1088 | 0.1172 | 0.1486 | 0.1606 | 0.5040 | 0.4234 | 0.0007 | 0.0007 | 0.0050 | 0.0176 | 0.0665 | 0.0987 | 0.0932 | 0.1319 | 0.5858 | ||
| SK-BR-3 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 949 | 628 | | 5444 | 5921 | 503.2 | 113.35 | 118.69 | 220.33 | 340 | 443 | 485 | 510 | 528 | 546 | 564 | 585 | 614 | 0.1099 | 651 | 1.294 | 20.22 | 8.60 | 1 | 0.0103 | 56 | 0.0029 | 17.80 | 6.312 | 0.3065 | 266047.0 | 145000000 | 80700000000 | 45600000000000 | 0.4084 | 0.2255 | 0.0003 | 0.0000 | 0.0008 | 0.0000 | 0.0026 | 0.0002 | 0.0074 | 0.0008 | 0.0372 | 0.0133 | 0.0597 | 0.0230 | 0.0638 | 0.0153 | 0.1089 | 0.0266 | 0.7193 | 0.9208 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0006 | 0.0004 | 0.0158 | 0.0130 | 0.0270 | 0.0200 | 0.0203 | 0.0120 | 0.0363 | 0.0200 | 0.8999 | 0.9346 | 0.0097 | 0.0000 | 0.0110 | 0.0789 | 0.0331 | 0.1579 | 0.0607 | 0.0789 | 0.1062 | 0.1842 | 0.1407 | 0.1053 | 0.1407 | 0.0789 | 0.1434 | 0.2105 | 0.3545 | 0.1053 | 0.0000 | 0.0009 | 0.0035 | 0.0087 | 0.0363 | 0.0603 | 0.0609 | 0.0873 | 0.7421 | 7 | 10 | 14 | 19 | 25 | 37 | 74 | 153 | 375 | 0.0775 | 22.34 | 4.056 | 0.5583 | 62626.7 | 51300000 | 50500000000 | 55700000000000 | 0.5274 | 0.1314 | 0.0603 | 0.0015 | 0.2190 | 0.0164 | 0.3175 | 0.0848 | 0.1429 | 0.1711 | 0.1524 | 0.2321 | 0.0603 | 0.2292 | 0.0222 | 0.1295 | 0.0159 | 0.0744 | 0.0095 | 0.0610 | 0.0013 | 0.0006 | 0.0051 | 0.0011 | 0.0019 | 0.0033 | 0.0103 | 0.0094 | 0.0994 | 0.0833 | 0.1186 | 0.1127 | 0.0962 | 0.0944 | 0.1237 | 0.1133 | 0.5436 | 0.5819 | 0.0000 | 0.0009 | 0.0016 | 0.0009 | 0.0072 | 0.0071 | 0.0177 | 0.0301 | 0.1157 | 0.1125 | 0.1301 | 0.1364 | 0.1028 | 0.0912 | 0.1205 | 0.1355 | 0.5044 | 0.4854 | 0.0007 | 0.0007 | 0.0036 | 0.0144 | 0.1114 | 0.1222 | 0.0978 | 0.1258 | 0.5234 | ||
| MCF7 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 590 | 585 | | 6499 | 12657 | 474.1 | 105.05 | 39.01 | 84.66 | 344 | 379 | 410 | 438 | 465 | 494 | 525 | 566 | 619 | 0.0658 | 833 | 0.436 | 85.09 | 24.33 | 2 | 0.0495 | 322 | 0.0005 | 98.02 | 7.849 | 0.1181 | 235821.0 | 123000000 | 66600000000 | 37500000000000 | 0.4186 | 0.2373 | 0.0003 | 0.0000 | 0.0010 | 0.0000 | 0.0081 | 0.0002 | 0.0234 | 0.0021 | 0.0846 | 0.0185 | 0.1319 | 0.0439 | 0.1403 | 0.0446 | 0.1617 | 0.0662 | 0.4487 | 0.8246 | 0.0002 | 0.0000 | 0.0000 | 0.0000 | 0.0017 | 0.0000 | 0.0075 | 0.0012 | 0.0359 | 0.0131 | 0.0667 | 0.0284 | 0.0658 | 0.0201 | 0.0850 | 0.0339 | 0.7372 | 0.9033 | 0.0024 | 0.0066 | 0.0072 | 0.0197 | 0.0168 | 0.0623 | 0.0455 | 0.1049 | 0.1310 | 0.2164 | 0.1566 | 0.1934 | 0.1054 | 0.1213 | 0.1454 | 0.1016 | 0.3898 | 0.1738 | 0.0007 | 0.0013 | 0.0093 | 0.0251 | 0.0753 | 0.1245 | 0.0951 | 0.1176 | 0.5510 | 8 | 10 | 11 | 13 | 14 | 16 | 20 | 32 | 83 | 0.3458 | 2.93 | 2.365 | 0.7930 | 8689.1 | 4200000 | 2620000000 | 1850000000000 | 0.5811 | 0.1080 | 0.0885 | 0.0104 | 0.2543 | 0.0345 | 0.2812 | 0.1127 | 0.1438 | 0.1577 | 0.1011 | 0.2117 | 0.0616 | 0.1837 | 0.0442 | 0.1186 | 0.0221 | 0.0840 | 0.0032 | 0.0866 | 0.0012 | 0.0043 | 0.0039 | 0.0074 | 0.0075 | 0.0086 | 0.0365 | 0.0296 | 0.0821 | 0.0734 | 0.1147 | 0.0932 | 0.0825 | 0.0839 | 0.1222 | 0.1175 | 0.5495 | 0.5820 | 0.0016 | 0.0023 | 0.0031 | 0.0012 | 0.0047 | 0.0059 | 0.0350 | 0.0457 | 0.0957 | 0.1019 | 0.1479 | 0.1547 | 0.0883 | 0.0873 | 0.1181 | 0.1131 | 0.5055 | 0.4880 | 0.0009 | 0.0059 | 0.0054 | 0.0345 | 0.0917 | 0.1226 | 0.0903 | 0.1207 | 0.5279 |
| MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 821 | 296 | | 10441 | 19427 | 121.6 | 37.86 | 144.94 | 161.51 | 79 | 90 | 99 | 108 | 116 | 126 | 138 | 153 | 174 | 0.0627 | 1218 | 0.254 | 218.68 | 45.79 | 4 | 0.0876 | 915 | 0.0020 | 18.42 | 6.592 | 0.2752 | 16229.4 | 2350000 | 367000000 | 61000000000 | 0.4705 | 0.1773 | 0.0012 | 0.0001 | 0.0034 | 0.0006 | 0.0120 | 0.0011 | 0.0412 | 0.0074 | 0.1063 | 0.0358 | 0.1638 | 0.0724 | 0.1588 | 0.0758 | 0.1756 | 0.1072 | 0.3378 | 0.6997 | 0.0007 | 0.0001 | 0.0015 | 0.0001 | 0.0029 | 0.0005 | 0.0135 | 0.0023 | 0.0368 | 0.0171 | 0.0641 | 0.0363 | 0.0621 | 0.0302 | 0.0774 | 0.0464 | 0.7412 | 0.8670 | 0.0044 | 0.0067 | 0.0016 | 0.0117 | 0.0148 | 0.0341 | 0.0487 | 0.0908 | 0.0907 | 0.1341 | 0.1362 | 0.1882 | 0.1286 | 0.1440 | 0.1354 | 0.1440 | 0.4395 | 0.2465 | 0.0006 | 0.0041 | 0.0103 | 0.0299 | 0.0638 | 0.1050 | 0.0907 | 0.1158 | 0.5798 | 11 | 14 | 20 | 40 | 78 | 132 | 194 | 273 | 378 | 0.0407 | 25.51 | 5.518 | 0.4667 | 47091.3 | 20600000 | 10800000000 | 6430000000000 | 0.5620 | 0.1280 | 0.0686 | 0.0021 | 0.1796 | 0.0256 | 0.2678 | 0.1420 | 0.1409 | 0.1373 | 0.1146 | 0.1747 | 0.0965 | 0.1718 | 0.0578 | 0.1136 | 0.0428 | 0.1049 | 0.0315 | 0.1281 | 0.0001 | 0.0004 | 0.0010 | 0.0007 | 0.0020 | 0.0019 | 0.0094 | 0.0061 | 0.0535 | 0.0466 | 0.1056 | 0.0854 | 0.0759 | 0.0627 | 0.1166 | 0.0964 | 0.6358 | 0.6997 | 0.0008 | 0.0011 | 0.0017 | 0.0029 | 0.0042 | 0.0088 | 0.0152 | 0.0241 | 0.0795 | 0.0957 | 0.1485 | 0.1575 | 0.0994 | 0.1066 | 0.1429 | 0.1449 | 0.5079 | 0.4585 | 0.0003 | 0.0016 | 0.0031 | 0.0113 | 0.0700 | 0.1221 | 0.0927 | 0.1315 | 0.5675 |
| MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 1167 | 689 | | 6111 | 11010 | 86.5 | 25.63 | 194.11 | 227.36 | 55 | 64 | 71 | 78 | 84 | 91 | 98 | 107 | 121 | 0.0750 | 826 | 0.733 | 215.47 | 54.20 | 4 | 0.0928 | 567 | 0.0034 | 11.76 | 5.994 | 0.3193 | 8137.3 | 828575 | 90900000 | 10700000000 | 0.4313 | 0.2183 | 0.0010 | 0.0004 | 0.0045 | 0.0006 | 0.0156 | 0.0018 | 0.0448 | 0.0075 | 0.1171 | 0.0342 | 0.1801 | 0.0744 | 0.1674 | 0.0795 | 0.1944 | 0.1213 | 0.2751 | 0.6804 | 0.0004 | 0.0004 | 0.0011 | 0.0000 | 0.0033 | 0.0004 | 0.0100 | 0.0028 | 0.0462 | 0.0179 | 0.0736 | 0.0369 | 0.0694 | 0.0341 | 0.1040 | 0.0529 | 0.6918 | 0.8547 | 0.0057 | 0.0065 | 0.0086 | 0.0161 | 0.0179 | 0.0581 | 0.0622 | 0.1113 | 0.1237 | 0.1597 | 0.1587 | 0.1968 | 0.1244 | 0.1323 | 0.1494 | 0.1419 | 0.3495 | 0.1774 | 0.0020 | 0.0037 | 0.0116 | 0.0317 | 0.0810 | 0.1161 | 0.1045 | 0.1324 | 0.5170 | 14 | 18 | 27 | 51 | 94 | 159 | 248 | 359 | 533 | 0.0198 | 121.90 | 6.448 | 0.3047 | 89366.6 | 55800000 | 41100000000 | 34000000000000 | 0.4757 | 0.1749 | 0.0822 | 0.0030 | 0.2716 | 0.0287 | 0.3153 | 0.2000 | 0.1093 | 0.1713 | 0.1103 | 0.1866 | 0.0562 | 0.1683 | 0.0416 | 0.0896 | 0.0083 | 0.0733 | 0.0052 | 0.0792 | 0.0007 | 0.0002 | 0.0002 | 0.0008 | 0.0034 | 0.0016 | 0.0104 | 0.0093 | 0.0707 | 0.0599 | 0.1227 | 0.1136 | 0.0860 | 0.0717 | 0.1146 | 0.1087 | 0.5914 | 0.6343 | 0.0006 | 0.0007 | 0.0014 | 0.0039 | 0.0046 | 0.0079 | 0.0149 | 0.0201 | 0.0879 | 0.0911 | 0.1479 | 0.1601 | 0.0948 | 0.0999 | 0.1390 | 0.1443 | 0.5088 | 0.4721 | 0.0003 | 0.0018 | 0.0059 | 0.0132 | 0.0749 | 0.1391 | 0.0892 | 0.1302 | 0.5455 |
| MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 892 | 808 | | 6094 | 19347 | 103.4 | 22.94 | 122.27 | 83.90 | 75 | 85 | 92 | 97 | 102 | 107 | 112 | 121 | 133 | 0.0484 | 936 | 1.125 | 94.85 | 31.83 | 1 | 0.0392 | 239 | 0.0039 | 10.98 | 5.900 | 0.3264 | 11210.4 | 1270000 | 152000000 | 18900000000 | 0.4570 | 0.2021 | 0.0000 | 0.0000 | 0.0012 | 0.0000 | 0.0075 | 0.0005 | 0.0217 | 0.0025 | 0.0681 | 0.0209 | 0.1205 | 0.0436 | 0.1287 | 0.0444 | 0.1709 | 0.0652 | 0.4814 | 0.8229 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0008 | 0.0003 | 0.0057 | 0.0008 | 0.0301 | 0.0158 | 0.0611 | 0.0257 | 0.0577 | 0.0203 | 0.0864 | 0.0360 | 0.7580 | 0.9009 | 0.0048 | 0.0034 | 0.0114 | 0.0034 | 0.0362 | 0.0638 | 0.0744 | 0.1577 | 0.1459 | 0.1745 | 0.1582 | 0.1980 | 0.1049 | 0.1040 | 0.1316 | 0.0973 | 0.3327 | 0.1980 | 0.0024 | 0.0044 | 0.0131 | 0.0346 | 0.0831 | 0.1291 | 0.1133 | 0.1439 | 0.4761 | 33 | 51 | 65 | 82 | 103 | 126 | 154 | 189 | 241 | 0.0030 | 24.00 | 6.471 | 0.3279 | 21987.3 | 5050000 | 1370000000 | 426000000000 | 0.5315 | 0.1249 | 0.0083 | 0.0021 | 0.0440 | 0.0066 | 0.1311 | 0.0164 | 0.1593 | 0.0533 | 0.1961 | 0.1147 | 0.1767 | 0.1669 | 0.1247 | 0.1521 | 0.0905 | 0.1695 | 0.0693 | 0.3187 | 0.0010 | 0.0006 | 0.0013 | 0.0017 | 0.0036 | 0.0031 | 0.0138 | 0.0108 | 0.0495 | 0.0346 | 0.0872 | 0.0628 | 0.0752 | 0.0624 | 0.1022 | 0.0842 | 0.6663 | 0.7398 | 0.0013 | 0.0023 | 0.0050 | 0.0054 | 0.0129 | 0.0159 | 0.0312 | 0.0399 | 0.0778 | 0.0899 | 0.1203 | 0.1442 | 0.1048 | 0.1188 | 0.1379 | 0.1445 | 0.5089 | 0.4391 | 0.0010 | 0.0027 | 0.0081 | 0.0215 | 0.0651 | 0.1056 | 0.0949 | 0.1211 | 0.5800 | ||
| MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 730 | 546 | | 7063 | 16463 | 184.9 | 40.76 | 99.35 | 87.89 | 137 | 151 | 161 | 169 | 179 | 190 | 202 | 219 | 240 | 0.0580 | 955 | 0.941 | 64.47 | 21.02 | 1 | 0.0239 | 169 | 0.0014 | 32.05 | 6.883 | 0.2025 | 35864.6 | 7300000 | 1560000000 | 348000000000 | 0.4301 | 0.2260 | 0.0000 | 0.0000 | 0.0009 | 0.0000 | 0.0035 | 0.0000 | 0.0175 | 0.0003 | 0.0785 | 0.0161 | 0.1523 | 0.0437 | 0.1574 | 0.0461 | 0.1936 | 0.0763 | 0.3963 | 0.8174 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0009 | 0.0000 | 0.0067 | 0.0003 | 0.0317 | 0.0110 | 0.0693 | 0.0226 | 0.0664 | 0.0177 | 0.0909 | 0.0300 | 0.7338 | 0.9185 | 0.0054 | 0.0134 | 0.0069 | 0.0214 | 0.0239 | 0.0456 | 0.0677 | 0.1877 | 0.1524 | 0.2091 | 0.1963 | 0.1743 | 0.1301 | 0.1072 | 0.1617 | 0.1099 | 0.2556 | 0.1314 | 0.0009 | 0.0041 | 0.0135 | 0.0340 | 0.0810 | 0.1216 | 0.1141 | 0.1377 | 0.4931 | 13 | 22 | 36 | 53 | 73 | 98 | 131 | 169 | 224 | 0.0086 | 26.48 | 6.137 | 0.3816 | 17595.6 | 4190000 | 1210000000 | 411000000000 | 0.4596 | 0.1971 | 0.0237 | 0.0019 | 0.1194 | 0.0081 | 0.2469 | 0.0504 | 0.1843 | 0.1053 | 0.1708 | 0.1723 | 0.1252 | 0.1953 | 0.0725 | 0.1462 | 0.0367 | 0.1457 | 0.0206 | 0.1747 | 0.0004 | 0.0003 | 0.0021 | 0.0017 | 0.0031 | 0.0027 | 0.0125 | 0.0104 | 0.0556 | 0.0435 | 0.0954 | 0.0686 | 0.0762 | 0.0660 | 0.1107 | 0.0934 | 0.6440 | 0.7133 | 0.0004 | 0.0007 | 0.0015 | 0.0031 | 0.0060 | 0.0094 | 0.0218 | 0.0307 | 0.0828 | 0.1016 | 0.1359 | 0.1542 | 0.1068 | 0.1143 | 0.1359 | 0.1477 | 0.5090 | 0.4384 | 0.0005 | 0.0005 | 0.0038 | 0.0189 | 0.0670 | 0.1146 | 0.0919 | 0.1238 | 0.5791 | ||
| Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 374 | 827 | | 538 | 5755 | 91.8 | 48.44 | 171.54 | 297.95 | 29 | 40 | 57 | 74 | 89 | 101 | 116 | 140 | 161 | 0.0895 | 515 | 1.275 | 31.62 | 12.17 | 2 | 0.1543 | 83 | 0.0025 | 70.15 | 6.080 | 0.1560 | 10772.9 | 1460000 | 216000000 | 34000000000 | 0.3272 | 0.2735 | 0.0000 | 0.0000 | 0.0282 | 0.0000 | 0.1338 | 0.0000 | 0.1901 | 0.0198 | 0.1620 | 0.1581 | 0.1268 | 0.1937 | 0.1479 | 0.1621 | 0.1056 | 0.1581 | 0.1056 | 0.3083 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0031 | 0.0000 | 0.0031 | 0.0131 | 0.0800 | 0.0551 | 0.0985 | 0.0866 | 0.0431 | 0.0525 | 0.1138 | 0.0840 | 0.6585 | 0.7087 | 0.0000 | 0.0000 | 0.0000 | 0.0156 | 0.0055 | 0.0000 | 0.0383 | 0.0156 | 0.1038 | 0.1328 | 0.1038 | 0.1016 | 0.1093 | 0.1016 | 0.1421 | 0.1328 | 0.4973 | 0.5000 | 0.0000 | 0.0000 | 0.0078 | 0.0389 | 0.0661 | 0.1128 | 0.0973 | 0.1128 | 0.5642 | 17 | 19 | 20 | 22 | 25 | 35 | 92 | 249 | 645 | 0.1812 | 27.53 | 3.742 | 0.6466 | 118185.0 | 112000000 | 119000000000 | 139000000000000 | 0.7250 | 0.0477 | 0.0600 | 0.0080 | 0.2240 | 0.0282 | 0.3600 | 0.1690 | 0.1600 | 0.1932 | 0.0920 | 0.2012 | 0.0480 | 0.1469 | 0.0240 | 0.1066 | 0.0240 | 0.0624 | 0.0080 | 0.0845 | 0.0000 | 0.0000 | 0.0007 | 0.0006 | 0.0020 | 0.0012 | 0.0231 | 0.0168 | 0.0909 | 0.0895 | 0.1324 | 0.1111 | 0.0856 | 0.0847 | 0.1232 | 0.1219 | 0.5422 | 0.5742 | 0.0000 | 0.0000 | 0.0047 | 0.0060 | 0.0087 | 0.0146 | 0.0379 | 0.0368 | 0.0883 | 0.0856 | 0.1270 | 0.1336 | 0.1017 | 0.0967 | 0.1222 | 0.1182 | 0.5095 | 0.5086 | 0.0000 | 0.0000 | 0.0086 | 0.0281 | 0.0944 | 0.1354 | 0.0929 | 0.1218 | 0.5187 |
| MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1018 | 411 | | 2600 | 6088 | 103.7 | 24.69 | 101.32 | 87.25 | 73 | 84 | 90 | 96 | 102 | 108 | 114 | 122 | 135 | 0.1304 | 794 | 0.757 | 122.10 | 28.23 | 2 | 0.1200 | 312 | 0.0039 | 11.20 | 5.825 | 0.3318 | 11365.0 | 1320000 | 161000000 | 21000000000 | 0.5268 | 0.1497 | 0.0006 | 0.0000 | 0.0037 | 0.0004 | 0.0141 | 0.0012 | 0.0263 | 0.0050 | 0.0912 | 0.0308 | 0.1769 | 0.0791 | 0.1622 | 0.0579 | 0.1714 | 0.0991 | 0.3537 | 0.7265 | 0.0005 | 0.0000 | 0.0014 | 0.0004 | 0.0038 | 0.0008 | 0.0100 | 0.0031 | 0.0491 | 0.0212 | 0.0920 | 0.0586 | 0.0734 | 0.0358 | 0.0972 | 0.0657 | 0.6725 | 0.8144 | 0.0043 | 0.0071 | 0.0259 | 0.0496 | 0.0237 | 0.0567 | 0.1034 | 0.1064 | 0.1315 | 0.2199 | 0.1810 | 0.1348 | 0.1099 | 0.1277 | 0.1142 | 0.1064 | 0.3060 | 0.1915 | 0.0033 | 0.0033 | 0.0181 | 0.0280 | 0.0954 | 0.1151 | 0.1127 | 0.1332 | 0.4910 | 24 | 33 | 44 | 57 | 72 | 91 | 120 | 163 | 222 | 0.0127 | 11.75 | 5.310 | 0.4411 | 17878.5 | 4610000 | 1580000000 | 681000000000 | 0.5373 | 0.1316 | 0.0246 | 0.0041 | 0.1026 | 0.0157 | 0.2041 | 0.0508 | 0.1688 | 0.1015 | 0.1709 | 0.1614 | 0.1368 | 0.1756 | 0.0887 | 0.1558 | 0.0641 | 0.1355 | 0.0395 | 0.1995 | 0.0022 | 0.0020 | 0.0051 | 0.0055 | 0.0091 | 0.0086 | 0.0215 | 0.0204 | 0.0680 | 0.0540 | 0.1066 | 0.0870 | 0.0844 | 0.0804 | 0.1135 | 0.1042 | 0.5897 | 0.6380 | 0.0022 | 0.0013 | 0.0039 | 0.0053 | 0.0061 | 0.0112 | 0.0259 | 0.0258 | 0.0783 | 0.0998 | 0.1517 | 0.1685 | 0.0998 | 0.1005 | 0.1224 | 0.1375 | 0.5097 | 0.4501 | 0.0027 | 0.0032 | 0.0163 | 0.0195 | 0.0736 | 0.1290 | 0.0940 | 0.1154 | 0.5463 |
| MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 448 | 583 | | 4870 | 11803 | 145.2 | 35.55 | 166.28 | 141.22 | 106 | 119 | 129 | 136 | 143 | 150 | 157 | 166 | 182 | 0.0848 | 1001 | 1.080 | 90.80 | 26.02 | 1 | 0.0448 | 218 | 0.0023 | 21.25 | 6.376 | 0.2593 | 22352.9 | 3700000 | 674000000 | 140000000000 | 0.5233 | 0.1537 | 0.0000 | 0.0000 | 0.0012 | 0.0002 | 0.0063 | 0.0020 | 0.0186 | 0.0059 | 0.0714 | 0.0204 | 0.1461 | 0.0576 | 0.1467 | 0.0492 | 0.1833 | 0.0730 | 0.4263 | 0.7916 | 0.0000 | 0.0000 | 0.0002 | 0.0002 | 0.0017 | 0.0013 | 0.0087 | 0.0044 | 0.0397 | 0.0176 | 0.0788 | 0.0439 | 0.0694 | 0.0279 | 0.1031 | 0.0468 | 0.6983 | 0.8580 | 0.0071 | 0.0138 | 0.0228 | 0.0276 | 0.0342 | 0.0369 | 0.1198 | 0.1244 | 0.1641 | 0.1982 | 0.1897 | 0.1935 | 0.1227 | 0.0599 | 0.1098 | 0.1152 | 0.2297 | 0.2304 | 0.0030 | 0.0056 | 0.0155 | 0.0494 | 0.0975 | 0.1375 | 0.1224 | 0.1538 | 0.4154 | 18 | 39 | 68 | 100 | 133 | 170 | 213 | 270 | 362 | 0.0037 | 57.89 | 6.920 | 0.2988 | 47591.3 | 18100000 | 8370000000 | 4450000000000 | 0.4521 | 0.1774 | 0.0099 | 0.0010 | 0.0727 | 0.0018 | 0.1824 | 0.0223 | 0.1760 | 0.0674 | 0.2042 | 0.1490 | 0.1715 | 0.2039 | 0.0989 | 0.1663 | 0.0578 | 0.1655 | 0.0267 | 0.2229 | 0.0002 | 0.0000 | 0.0010 | 0.0008 | 0.0039 | 0.0034 | 0.0108 | 0.0072 | 0.0510 | 0.0340 | 0.0877 | 0.0683 | 0.0730 | 0.0617 | 0.1087 | 0.0831 | 0.6637 | 0.7415 | 0.0013 | 0.0019 | 0.0013 | 0.0061 | 0.0077 | 0.0145 | 0.0286 | 0.0352 | 0.0848 | 0.1044 | 0.1358 | 0.1322 | 0.1054 | 0.1131 | 0.1247 | 0.1251 | 0.5106 | 0.4674 | 0.0006 | 0.0029 | 0.0045 | 0.0181 | 0.0642 | 0.1082 | 0.0990 | 0.1199 | 0.5826 | ||
| Hs 578T | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 1199 | 269 | | 6858 | 34380 | 182.5 | 52.85 | 124.86 | 199.10 | 122 | 141 | 154 | 165 | 177 | 190 | 204 | 222 | 256 | 0.0332 | 1142 | 0.787 | 31.00 | 8.06 | 3 | 0.0117 | 80 | 0.0011 | 37.84 | 7.176 | 0.1947 | 36107.4 | 7670000 | 1740000000 | 418000000000 | 0.4164 | 0.2188 | 0.0008 | 0.0000 | 0.0016 | 0.0003 | 0.0074 | 0.0003 | 0.0251 | 0.0031 | 0.0740 | 0.0238 | 0.1294 | 0.0417 | 0.1524 | 0.0466 | 0.1762 | 0.0732 | 0.4332 | 0.8108 | 0.0004 | 0.0000 | 0.0004 | 0.0000 | 0.0034 | 0.0000 | 0.0103 | 0.0012 | 0.0321 | 0.0128 | 0.0530 | 0.0208 | 0.0614 | 0.0187 | 0.0821 | 0.0317 | 0.7569 | 0.9147 | 0.0035 | 0.0089 | 0.0090 | 0.0089 | 0.0097 | 0.0222 | 0.0520 | 0.0532 | 0.0929 | 0.1064 | 0.1283 | 0.1241 | 0.0999 | 0.1004 | 0.1200 | 0.1241 | 0.4847 | 0.4520 | 0.0016 | 0.0038 | 0.0074 | 0.0272 | 0.0579 | 0.0886 | 0.0908 | 0.1164 | 0.6063 | 17 | 21 | 25 | 29 | 35 | 48 | 91 | 194 | 364 | 0.0577 | 29.38 | 4.737 | 0.5383 | 55230.0 | 41200000 | 40500000000 | 47700000000000 | 0.3925 | 0.2378 | 0.1380 | 0.0050 | 0.3601 | 0.0465 | 0.2981 | 0.2724 | 0.1080 | 0.2297 | 0.0587 | 0.1914 | 0.0244 | 0.1219 | 0.0089 | 0.0649 | 0.0028 | 0.0419 | 0.0011 | 0.0263 | 0.0001 | 0.0001 | 0.0004 | 0.0005 | 0.0019 | 0.0020 | 0.0186 | 0.0147 | 0.0758 | 0.0670 | 0.1162 | 0.0990 | 0.0798 | 0.0694 | 0.1195 | 0.1071 | 0.5878 | 0.6402 | 0.0002 | 0.0003 | 0.0007 | 0.0022 | 0.0033 | 0.0056 | 0.0256 | 0.0302 | 0.0905 | 0.0964 | 0.1439 | 0.1483 | 0.0934 | 0.1014 | 0.1314 | 0.1378 | 0.5108 | 0.4778 | 0.0002 | 0.0007 | 0.0022 | 0.0238 | 0.0786 | 0.1331 | 0.0854 | 0.1281 | 0.5480 |
| MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1098 | 160 | | 13724 | 21102 | 109.6 | 32.03 | 139.67 | 113.32 | 75 | 84 | 91 | 97 | 104 | 112 | 121 | 133 | 152 | 0.0598 | 1262 | 0.543 | 155.77 | 38.28 | 1 | 0.0358 | 491 | 0.0012 | 36.99 | 7.099 | 0.2067 | 13040.5 | 1690000 | 237000000 | 36400000000 | 0.4757 | 0.1867 | 0.0010 | 0.0001 | 0.0041 | 0.0003 | 0.0130 | 0.0016 | 0.0426 | 0.0043 | 0.0995 | 0.0236 | 0.1665 | 0.0560 | 0.1630 | 0.0574 | 0.1878 | 0.0954 | 0.3226 | 0.7614 | 0.0005 | 0.0001 | 0.0013 | 0.0001 | 0.0034 | 0.0002 | 0.0125 | 0.0008 | 0.0402 | 0.0130 | 0.0734 | 0.0252 | 0.0716 | 0.0218 | 0.1009 | 0.0456 | 0.6963 | 0.8934 | 0.0044 | 0.0054 | 0.0078 | 0.0168 | 0.0271 | 0.0337 | 0.0640 | 0.0804 | 0.1118 | 0.1692 | 0.1406 | 0.1937 | 0.1349 | 0.1026 | 0.1386 | 0.1394 | 0.3707 | 0.2588 | 0.0024 | 0.0058 | 0.0129 | 0.0351 | 0.0814 | 0.1154 | 0.0950 | 0.1140 | 0.5380 | 25 | 40 | 60 | 83 | 110 | 142 | 177 | 222 | 298 | 0.0094 | 10.78 | 5.597 | 0.4544 | 32349.4 | 10000000 | 3730000000 | 1590000000000 | 0.5105 | 0.1695 | 0.0131 | 0.0019 | 0.0728 | 0.0040 | 0.1644 | 0.0224 | 0.1683 | 0.0713 | 0.1736 | 0.1476 | 0.1439 | 0.1890 | 0.1111 | 0.1477 | 0.0831 | 0.1506 | 0.0697 | 0.2653 | 0.0009 | 0.0007 | 0.0013 | 0.0014 | 0.0035 | 0.0034 | 0.0133 | 0.0126 | 0.0502 | 0.0386 | 0.0839 | 0.0657 | 0.0680 | 0.0578 | 0.1044 | 0.0854 | 0.6745 | 0.7344 | 0.0012 | 0.0013 | 0.0045 | 0.0041 | 0.0086 | 0.0141 | 0.0281 | 0.0380 | 0.0821 | 0.1031 | 0.1290 | 0.1509 | 0.1030 | 0.1107 | 0.1319 | 0.1375 | 0.5116 | 0.4403 | 0.0013 | 0.0019 | 0.0052 | 0.0196 | 0.0680 | 0.1022 | 0.0904 | 0.1250 | 0.5864 |
| MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 609 | 654 | | 7151 | 16942 | 197.2 | 47.67 | 158.72 | 128.62 | 142 | 158 | 169 | 180 | 191 | 204 | 217 | 235 | 262 | 0.0596 | 1009 | 1.165 | 114.14 | 40.26 | 1 | 0.0386 | 276 | 0.0010 | 44.53 | 7.179 | 0.1807 | 41154.1 | 9080000 | 2110000000 | 515000000000 | 0.4398 | 0.2146 | 0.0005 | 0.0000 | 0.0007 | 0.0000 | 0.0034 | 0.0005 | 0.0225 | 0.0016 | 0.0918 | 0.0226 | 0.1658 | 0.0544 | 0.1623 | 0.0541 | 0.1830 | 0.0721 | 0.3699 | 0.7947 | 0.0002 | 0.0000 | 0.0005 | 0.0000 | 0.0014 | 0.0003 | 0.0087 | 0.0007 | 0.0377 | 0.0140 | 0.0650 | 0.0283 | 0.0655 | 0.0241 | 0.0987 | 0.0339 | 0.7223 | 0.8987 | 0.0043 | 0.0021 | 0.0080 | 0.0062 | 0.0217 | 0.0331 | 0.0810 | 0.1198 | 0.1389 | 0.1818 | 0.1975 | 0.2293 | 0.1172 | 0.1198 | 0.1404 | 0.1446 | 0.2909 | 0.1632 | 0.0015 | 0.0028 | 0.0067 | 0.0294 | 0.0781 | 0.1246 | 0.1136 | 0.1476 | 0.4957 | 29 | 50 | 73 | 98 | 124 | 154 | 195 | 255 | 340 | 0.0025 | 49.37 | 6.896 | 0.3087 | 41734.7 | 14900000 | 6570000000 | 3430000000000 | 0.4757 | 0.1683 | 0.0102 | 0.0005 | 0.0551 | 0.0051 | 0.1533 | 0.0172 | 0.1688 | 0.0526 | 0.1754 | 0.1321 | 0.1767 | 0.1793 | 0.1141 | 0.1494 | 0.0913 | 0.1597 | 0.0551 | 0.3041 | 0.0000 | 0.0002 | 0.0006 | 0.0008 | 0.0042 | 0.0018 | 0.0120 | 0.0073 | 0.0502 | 0.0359 | 0.0871 | 0.0632 | 0.0784 | 0.0546 | 0.1087 | 0.0842 | 0.6587 | 0.7522 | 0.0021 | 0.0007 | 0.0015 | 0.0035 | 0.0069 | 0.0106 | 0.0218 | 0.0308 | 0.0832 | 0.0946 | 0.1321 | 0.1464 | 0.1017 | 0.1114 | 0.1388 | 0.1415 | 0.5118 | 0.4604 | 0.0011 | 0.0012 | 0.0050 | 0.0180 | 0.0637 | 0.1167 | 0.0942 | 0.1257 | 0.5744 | ||
| MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 193 | 840 | | 364 | 9991 | 79.4 | 12.33 | 120.69 | 125.11 | 64 | 69 | 71 | 74 | 78 | 82 | 86 | 91 | 97 | 0.0656 | 655 | 0.892 | 100.23 | 30.02 | 0 | 0.7033 | 256 | 0.0097 | 8.20 | 4.818 | 0.3329 | 6458.0 | 537560 | 45800000 | 3980000000 | 0.4026 | 0.2222 | 0.0000 | 0.0000 | 0.0248 | 0.0028 | 0.0106 | 0.0055 | 0.0496 | 0.0138 | 0.1028 | 0.0608 | 0.1950 | 0.1326 | 0.1915 | 0.0856 | 0.2340 | 0.1105 | 0.1915 | 0.5884 | 0.0000 | 0.0000 | 0.0210 | 0.0027 | 0.0060 | 0.0055 | 0.0330 | 0.0137 | 0.0571 | 0.0604 | 0.1171 | 0.1319 | 0.0781 | 0.0742 | 0.1171 | 0.0934 | 0.5706 | 0.6181 | 0.0196 | 0.0000 | 0.0980 | 1.0000 | 0.0392 | 0.0000 | 0.2549 | 0.0000 | 0.1765 | 0.0000 | 0.2157 | 0.0000 | 0.0980 | 0.0000 | 0.0980 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0229 | 0.0571 | 0.0400 | 0.0971 | 0.1371 | 0.1371 | 0.1771 | 0.3314 | 24 | 37 | 47 | 57 | 70 | 90 | 126 | 190 | 293 | 0.0082 | 25.67 | 5.863 | 0.4219 | 30214.6 | 11500000 | 5470000000 | 2990000000000 | 0.6670 | 0.0790 | 0.0168 | 0.0063 | 0.0841 | 0.0145 | 0.1639 | 0.0396 | 0.1869 | 0.0903 | 0.1913 | 0.1538 | 0.1665 | 0.1778 | 0.0939 | 0.1436 | 0.0709 | 0.1429 | 0.0257 | 0.2312 | 0.0013 | 0.0029 | 0.0042 | 0.0050 | 0.0088 | 0.0091 | 0.0255 | 0.0213 | 0.0682 | 0.0615 | 0.1043 | 0.0886 | 0.0823 | 0.0797 | 0.1139 | 0.1042 | 0.5915 | 0.6276 | 0.0008 | 0.0009 | 0.0049 | 0.0070 | 0.0167 | 0.0127 | 0.0318 | 0.0417 | 0.0864 | 0.0961 | 0.1262 | 0.1298 | 0.0936 | 0.1039 | 0.1259 | 0.1373 | 0.5136 | 0.4706 | 0.0016 | 0.0055 | 0.0109 | 0.0257 | 0.0792 | 0.1136 | 0.0911 | 0.1171 | 0.5553 |
| MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1169 | 718 | | 3803 | 6960 | 84.4 | 20.56 | 84.20 | 75.35 | 60 | 68 | 73 | 77 | 82 | 88 | 94 | 101 | 111 | 0.1295 | 901 | 1.055 | 100.65 | 36.80 | 3 | 0.0702 | 267 | 0.0048 | 9.98 | 5.662 | 0.3488 | 7539.7 | 712809 | 71300000 | 7550000000 | 0.4461 | 0.2010 | 0.0035 | 0.0000 | 0.0035 | 0.0006 | 0.0133 | 0.0014 | 0.0434 | 0.0049 | 0.1018 | 0.0301 | 0.1540 | 0.0703 | 0.1717 | 0.0627 | 0.1965 | 0.1162 | 0.3124 | 0.7138 | 0.0007 | 0.0000 | 0.0013 | 0.0003 | 0.0026 | 0.0008 | 0.0141 | 0.0025 | 0.0434 | 0.0234 | 0.0736 | 0.0485 | 0.0696 | 0.0294 | 0.0923 | 0.0539 | 0.7024 | 0.8412 | 0.0038 | 0.0423 | 0.0153 | 0.0329 | 0.0204 | 0.0798 | 0.1008 | 0.1596 | 0.1288 | 0.1831 | 0.1760 | 0.2019 | 0.1492 | 0.1221 | 0.1620 | 0.0845 | 0.2436 | 0.0939 | 0.0016 | 0.0066 | 0.0131 | 0.0334 | 0.0826 | 0.1067 | 0.1100 | 0.1379 | 0.5082 | 21 | 29 | 36 | 45 | 57 | 72 | 93 | 129 | 196 | 0.0215 | 6.08 | 4.792 | 0.5469 | 12767.1 | 2810000 | 768000000 | 242000000000 | 0.5949 | 0.1190 | 0.0236 | 0.0027 | 0.0754 | 0.0155 | 0.1471 | 0.0354 | 0.1680 | 0.0787 | 0.1916 | 0.1437 | 0.1471 | 0.1641 | 0.1235 | 0.1433 | 0.0836 | 0.1636 | 0.0400 | 0.2530 | 0.0027 | 0.0010 | 0.0061 | 0.0052 | 0.0097 | 0.0081 | 0.0289 | 0.0240 | 0.0729 | 0.0672 | 0.1069 | 0.0930 | 0.0901 | 0.0750 | 0.1103 | 0.1066 | 0.5724 | 0.6198 | 0.0048 | 0.0038 | 0.0112 | 0.0038 | 0.0117 | 0.0102 | 0.0363 | 0.0326 | 0.0811 | 0.0856 | 0.1323 | 0.1475 | 0.0961 | 0.0958 | 0.1126 | 0.1315 | 0.5139 | 0.4891 | 0.0013 | 0.0093 | 0.0160 | 0.0388 | 0.0835 | 0.1210 | 0.0923 | 0.1151 | 0.5228 |
| MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1098 | 496 | | 1949 | 1938 | 124.8 | 50.11 | 251.47 | 187.75 | 64 | 82 | 94 | 105 | 119 | 134 | 149 | 168 | 192 | 0.1858 | 360 | 0.821 | 96.77 | 26.42 | 1 | 0.1442 | 281 | 0.0008 | 114.59 | 7.204 | 0.1050 | 18080.3 | 2940000 | 523000000 | 100000000000 | 0.5094 | 0.1519 | 0.0015 | 0.0000 | 0.0073 | 0.0000 | 0.0601 | 0.0008 | 0.1246 | 0.0061 | 0.2463 | 0.0736 | 0.2625 | 0.1753 | 0.1540 | 0.1578 | 0.0748 | 0.1700 | 0.0689 | 0.4165 | 0.0008 | 0.0000 | 0.0000 | 0.0000 | 0.0016 | 0.0000 | 0.0103 | 0.0036 | 0.0745 | 0.0379 | 0.1149 | 0.0752 | 0.0745 | 0.0578 | 0.1117 | 0.0848 | 0.6117 | 0.7407 | 0.0000 | 0.0000 | 0.0052 | 0.0058 | 0.0086 | 0.0116 | 0.0448 | 0.0785 | 0.1345 | 0.2006 | 0.2103 | 0.2209 | 0.0845 | 0.0930 | 0.1379 | 0.1483 | 0.3741 | 0.2413 | 0.0000 | 0.0022 | 0.0078 | 0.0201 | 0.0983 | 0.1497 | 0.0927 | 0.1352 | 0.4939 | 69 | 95 | 125 | 160 | 191 | 236 | 305 | 403 | 529 | 0.0029 | 36.15 | 6.309 | 0.2943 | 98467.7 | 51400000 | 32500000000 | 23600000000000 | 0.4492 | 0.1782 | 0.0235 | 0.0014 | 0.0882 | 0.0096 | 0.2235 | 0.0193 | 0.1559 | 0.0674 | 0.1500 | 0.1747 | 0.1118 | 0.1678 | 0.0941 | 0.1307 | 0.0735 | 0.1321 | 0.0794 | 0.2971 | 0.0022 | 0.0000 | 0.0011 | 0.0000 | 0.0032 | 0.0033 | 0.0194 | 0.0124 | 0.0809 | 0.0521 | 0.1143 | 0.0884 | 0.0895 | 0.0711 | 0.1219 | 0.1207 | 0.5674 | 0.6521 | 0.0000 | 0.0000 | 0.0085 | 0.0083 | 0.0085 | 0.0145 | 0.0341 | 0.0311 | 0.0937 | 0.1284 | 0.1312 | 0.1139 | 0.1039 | 0.0911 | 0.1039 | 0.1304 | 0.5162 | 0.4824 | 0.0000 | 0.0027 | 0.0000 | 0.0396 | 0.0723 | 0.1432 | 0.0900 | 0.1050 | 0.5471 |
| BT-20 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 158 | 814 | | 6792 | 9233 | 438.4 | 87.62 | 129.25 | 126.89 | 328 | 360 | 387 | 410 | 432 | 453 | 478 | 510 | 563 | 0.1039 | 959 | 1.120 | 105.12 | 29.02 | 1 | 0.0346 | 235 | 0.0009 | 45.63 | 7.284 | 0.1766 | 199847.0 | 94600000 | 46500000000 | 23600000000000 | 0.4114 | 0.2340 | 0.0002 | 0.0000 | 0.0009 | 0.0002 | 0.0029 | 0.0003 | 0.0152 | 0.0014 | 0.0530 | 0.0166 | 0.1082 | 0.0302 | 0.1148 | 0.0269 | 0.1594 | 0.0440 | 0.5454 | 0.8804 | 0.0002 | 0.0000 | 0.0005 | 0.0000 | 0.0012 | 0.0000 | 0.0064 | 0.0000 | 0.0246 | 0.0109 | 0.0515 | 0.0199 | 0.0494 | 0.0108 | 0.0729 | 0.0223 | 0.7933 | 0.9361 | 0.0091 | 0.0087 | 0.0172 | 0.0435 | 0.0199 | 0.0913 | 0.0661 | 0.1174 | 0.1024 | 0.2261 | 0.1386 | 0.1174 | 0.1232 | 0.1739 | 0.1132 | 0.0870 | 0.4103 | 0.1348 | 0.0006 | 0.0025 | 0.0094 | 0.0253 | 0.0738 | 0.1200 | 0.1088 | 0.1385 | 0.5211 | 15 | 21 | 36 | 60 | 91 | 123 | 163 | 221 | 310 | 0.0144 | 22.41 | 5.893 | 0.4120 | 32805.8 | 11500000 | 4920000000 | 2420000000000 | 0.5918 | 0.1102 | 0.0326 | 0.0008 | 0.0932 | 0.0126 | 0.1546 | 0.0502 | 0.1430 | 0.0942 | 0.1492 | 0.1468 | 0.1430 | 0.1554 | 0.1072 | 0.1181 | 0.1049 | 0.1370 | 0.0723 | 0.2849 | 0.0002 | 0.0000 | 0.0012 | 0.0004 | 0.0062 | 0.0042 | 0.0208 | 0.0156 | 0.0649 | 0.0540 | 0.0900 | 0.0828 | 0.0815 | 0.0608 | 0.1083 | 0.0905 | 0.6269 | 0.6917 | 0.0017 | 0.0008 | 0.0031 | 0.0078 | 0.0133 | 0.0090 | 0.0269 | 0.0377 | 0.0941 | 0.1099 | 0.1339 | 0.1333 | 0.0896 | 0.1005 | 0.1210 | 0.1255 | 0.5164 | 0.4754 | 0.0009 | 0.0028 | 0.0079 | 0.0247 | 0.0791 | 0.1123 | 0.0879 | 0.1140 | 0.5705 | ||
| MCF7 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 1187 | 150 | | 10144 | 18089 | 422.6 | 104.34 | 134.81 | 165.74 | 292 | 329 | 360 | 387 | 413 | 441 | 470 | 509 | 564 | 0.0612 | 1107 | 0.929 | 101.98 | 22.83 | 1 | 0.0219 | 222 | 0.0007 | 49.57 | 7.512 | 0.1760 | 189470.0 | 89800000 | 44900000000 | 23500000000000 | 0.4318 | 0.2153 | 0.0002 | 0.0000 | 0.0024 | 0.0001 | 0.0055 | 0.0009 | 0.0213 | 0.0034 | 0.0707 | 0.0216 | 0.1408 | 0.0424 | 0.1325 | 0.0444 | 0.1711 | 0.0653 | 0.4554 | 0.8220 | 0.0001 | 0.0000 | 0.0004 | 0.0001 | 0.0019 | 0.0004 | 0.0069 | 0.0013 | 0.0283 | 0.0125 | 0.0547 | 0.0201 | 0.0594 | 0.0179 | 0.0803 | 0.0312 | 0.7681 | 0.9165 | 0.0039 | 0.0043 | 0.0072 | 0.0130 | 0.0101 | 0.0391 | 0.0568 | 0.1014 | 0.0901 | 0.1681 | 0.1710 | 0.2087 | 0.1098 | 0.1087 | 0.1349 | 0.1406 | 0.4162 | 0.2159 | 0.0006 | 0.0029 | 0.0063 | 0.0240 | 0.0632 | 0.1112 | 0.1004 | 0.1280 | 0.5634 | 7 | 10 | 15 | 31 | 61 | 108 | 168 | 251 | 373 | 0.0482 | 25.89 | 5.272 | 0.4507 | 45643.3 | 21300000 | 12000000000 | 7760000000000 | 0.5745 | 0.1113 | 0.0713 | 0.0037 | 0.2521 | 0.0324 | 0.2954 | 0.1786 | 0.1297 | 0.1970 | 0.0926 | 0.1848 | 0.0798 | 0.1557 | 0.0420 | 0.0909 | 0.0207 | 0.0701 | 0.0164 | 0.0869 | 0.0003 | 0.0000 | 0.0006 | 0.0001 | 0.0007 | 0.0005 | 0.0145 | 0.0119 | 0.0699 | 0.0593 | 0.1238 | 0.1008 | 0.0735 | 0.0705 | 0.1173 | 0.1039 | 0.5995 | 0.6530 | 0.0002 | 0.0004 | 0.0020 | 0.0012 | 0.0034 | 0.0064 | 0.0225 | 0.0278 | 0.0856 | 0.0911 | 0.1447 | 0.1588 | 0.0900 | 0.0998 | 0.1345 | 0.1395 | 0.5171 | 0.4750 | 0.0006 | 0.0008 | 0.0028 | 0.0201 | 0.0798 | 0.1283 | 0.0907 | 0.1237 | 0.5531 |
| BT-20 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 137 | 324 | | 5641 | 20747 | 281.5 | 64.71 | 102.70 | 136.65 | 202 | 225 | 243 | 262 | 277 | 293 | 311 | 335 | 366 | 0.0556 | 1153 | 0.979 | 115.25 | 26.87 | 1 | 0.0456 | 257 | 0.0006 | 71.66 | 7.549 | 0.1440 | 83449.7 | 26000000 | 8510000000 | 2920000000000 | 0.4017 | 0.2486 | 0.0003 | 0.0000 | 0.0006 | 0.0000 | 0.0038 | 0.0000 | 0.0232 | 0.0027 | 0.0713 | 0.0198 | 0.1447 | 0.0392 | 0.1676 | 0.0472 | 0.1783 | 0.0677 | 0.4103 | 0.8235 | 0.0002 | 0.0000 | 0.0002 | 0.0000 | 0.0013 | 0.0000 | 0.0102 | 0.0011 | 0.0291 | 0.0141 | 0.0555 | 0.0255 | 0.0700 | 0.0224 | 0.0851 | 0.0349 | 0.7483 | 0.9020 | 0.0009 | 0.0074 | 0.0085 | 0.0257 | 0.0180 | 0.0662 | 0.0722 | 0.1029 | 0.1472 | 0.1838 | 0.1918 | 0.1618 | 0.1149 | 0.1360 | 0.1434 | 0.1140 | 0.3029 | 0.2022 | 0.0023 | 0.0015 | 0.0072 | 0.0281 | 0.0795 | 0.1228 | 0.1049 | 0.1327 | 0.5209 | 11 | 14 | 17 | 23 | 35 | 63 | 115 | 185 | 286 | 0.0458 | 14.71 | 4.863 | 0.5260 | 29220.6 | 12900000 | 7580000000 | 5510000000000 | 0.5276 | 0.1342 | 0.0999 | 0.0045 | 0.3282 | 0.0294 | 0.3393 | 0.1714 | 0.1201 | 0.2314 | 0.0597 | 0.2369 | 0.0285 | 0.1756 | 0.0132 | 0.0762 | 0.0090 | 0.0458 | 0.0021 | 0.0287 | 0.0003 | 0.0002 | 0.0004 | 0.0007 | 0.0014 | 0.0014 | 0.0118 | 0.0117 | 0.0724 | 0.0573 | 0.1165 | 0.1003 | 0.0799 | 0.0698 | 0.1094 | 0.0976 | 0.6080 | 0.6610 | 0.0005 | 0.0006 | 0.0012 | 0.0025 | 0.0034 | 0.0047 | 0.0207 | 0.0211 | 0.0878 | 0.0967 | 0.1435 | 0.1663 | 0.0940 | 0.0978 | 0.1317 | 0.1352 | 0.5172 | 0.4752 | 0.0002 | 0.0006 | 0.0024 | 0.0191 | 0.0743 | 0.1338 | 0.0863 | 0.1178 | 0.5656 |
| MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 1158 | 547 | | 3628 | 6182 | 70.1 | 18.21 | 293.38 | 247.61 | 48 | 56 | 61 | 65 | 68 | 73 | 77 | 84 | 93 | 0.1234 | 763 | 0.764 | 96.33 | 26.17 | 2 | 0.0714 | 259 | 0.0063 | 7.41 | 5.408 | 0.3836 | 5245.5 | 419586 | 36100000 | 3360000000 | 0.4909 | 0.1773 | 0.0023 | 0.0000 | 0.0055 | 0.0006 | 0.0137 | 0.0022 | 0.0339 | 0.0099 | 0.0870 | 0.0304 | 0.1612 | 0.0565 | 0.1658 | 0.0624 | 0.1557 | 0.1052 | 0.3750 | 0.7327 | 0.0000 | 0.0000 | 0.0003 | 0.0003 | 0.0021 | 0.0006 | 0.0086 | 0.0049 | 0.0429 | 0.0204 | 0.0689 | 0.0357 | 0.0703 | 0.0319 | 0.0998 | 0.0512 | 0.7071 | 0.8550 | 0.0014 | 0.0156 | 0.0205 | 0.0156 | 0.0533 | 0.1172 | 0.0861 | 0.1367 | 0.1516 | 0.1797 | 0.1954 | 0.1680 | 0.1175 | 0.1016 | 0.1434 | 0.0977 | 0.2309 | 0.1680 | 0.0029 | 0.0041 | 0.0140 | 0.0479 | 0.0918 | 0.1350 | 0.1227 | 0.1508 | 0.4307 | 31 | 70 | 122 | 175 | 230 | 293 | 376 | 483 | 655 | 0.0026 | 110.17 | 7.306 | 0.2160 | 147376.0 | 96400000 | 74100000000 | 63400000000000 | 0.5179 | 0.1541 | 0.0174 | 0.0019 | 0.0872 | 0.0087 | 0.1851 | 0.0367 | 0.1986 | 0.0783 | 0.1928 | 0.1522 | 0.1415 | 0.2011 | 0.0688 | 0.1609 | 0.0736 | 0.1542 | 0.0349 | 0.2059 | 0.0013 | 0.0005 | 0.0023 | 0.0022 | 0.0085 | 0.0027 | 0.0214 | 0.0121 | 0.0628 | 0.0486 | 0.0986 | 0.0955 | 0.0832 | 0.0720 | 0.1216 | 0.1055 | 0.6003 | 0.6608 | 0.0015 | 0.0037 | 0.0040 | 0.0086 | 0.0119 | 0.0165 | 0.0308 | 0.0354 | 0.0826 | 0.0886 | 0.1323 | 0.1405 | 0.0930 | 0.1069 | 0.1264 | 0.1497 | 0.5174 | 0.4502 | 0.0012 | 0.0016 | 0.0113 | 0.0311 | 0.0638 | 0.1179 | 0.0973 | 0.1179 | 0.5579 |
| Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1125 | 294 | | 3689 | 5640 | 111.6 | 32.45 | 209.00 | 240.70 | 71 | 82 | 92 | 101 | 109 | 118 | 128 | 138 | 154 | 0.1225 | 691 | 1.145 | 36.89 | 14.32 | 4 | 0.0268 | 99 | 0.0011 | 36.53 | 6.994 | 0.1873 | 13497.5 | 1760000 | 244000000 | 36000000000 | 0.4226 | 0.2234 | 0.0011 | 0.0003 | 0.0055 | 0.0006 | 0.0082 | 0.0023 | 0.0448 | 0.0074 | 0.1055 | 0.0366 | 0.1393 | 0.0563 | 0.1650 | 0.0738 | 0.1984 | 0.1039 | 0.3322 | 0.7187 | 0.0007 | 0.0003 | 0.0026 | 0.0006 | 0.0022 | 0.0012 | 0.0137 | 0.0056 | 0.0290 | 0.0222 | 0.0475 | 0.0275 | 0.0561 | 0.0333 | 0.0750 | 0.0447 | 0.7732 | 0.8647 | 0.0046 | 0.0120 | 0.0174 | 0.0090 | 0.0231 | 0.0270 | 0.0556 | 0.1261 | 0.1088 | 0.1411 | 0.1574 | 0.1952 | 0.1088 | 0.1111 | 0.1586 | 0.1441 | 0.3657 | 0.2342 | 0.0029 | 0.0029 | 0.0080 | 0.0264 | 0.0568 | 0.0998 | 0.1096 | 0.1234 | 0.5703 | 25 | 37 | 55 | 75 | 103 | 150 | 232 | 361 | 559 | 0.0196 | 21.82 | 5.398 | 0.4816 | 101607.0 | 71300000 | 60000000000 | 56400000000000 | 0.6220 | 0.0932 | 0.0428 | 0.0027 | 0.1732 | 0.0150 | 0.3230 | 0.0707 | 0.2043 | 0.1405 | 0.1012 | 0.2102 | 0.0700 | 0.2191 | 0.0389 | 0.1104 | 0.0253 | 0.1051 | 0.0214 | 0.1263 | 0.0000 | 0.0008 | 0.0014 | 0.0008 | 0.0028 | 0.0040 | 0.0247 | 0.0127 | 0.0669 | 0.0618 | 0.1125 | 0.0907 | 0.0807 | 0.0713 | 0.1210 | 0.1125 | 0.5899 | 0.6455 | 0.0006 | 0.0014 | 0.0013 | 0.0022 | 0.0050 | 0.0086 | 0.0264 | 0.0402 | 0.0866 | 0.0782 | 0.1281 | 0.1407 | 0.1017 | 0.1070 | 0.1318 | 0.1386 | 0.5185 | 0.4831 | 0.0006 | 0.0011 | 0.0044 | 0.0237 | 0.0860 | 0.1113 | 0.0970 | 0.1333 | 0.5427 |
| MCF 10A | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 726 | 600 | | 3242 | 14311 | 499.5 | 83.43 | 217.74 | 192.04 | 394 | 426 | 450 | 470 | 493 | 518 | 547 | 576 | 612 | 0.0641 | 917 | 0.675 | 101.83 | 25.18 | 1 | 0.0999 | 324 | 0.0014 | 30.06 | 6.786 | 0.2232 | 256441.0 | 135000000 | 73000000000 | 40400000000000 | 0.4615 | 0.1909 | 0.0000 | 0.0000 | 0.0008 | 0.0000 | 0.0029 | 0.0003 | 0.0094 | 0.0019 | 0.0476 | 0.0128 | 0.1034 | 0.0350 | 0.0932 | 0.0172 | 0.1211 | 0.0428 | 0.6215 | 0.8900 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0007 | 0.0003 | 0.0031 | 0.0015 | 0.0241 | 0.0115 | 0.0544 | 0.0319 | 0.0457 | 0.0124 | 0.0582 | 0.0254 | 0.8139 | 0.9170 | 0.0069 | 0.2000 | 0.0185 | 0.2000 | 0.0254 | 0.1333 | 0.0762 | 0.2667 | 0.1224 | 0.0667 | 0.2517 | 0.1333 | 0.1201 | 0.0000 | 0.1386 | 0.0000 | 0.2402 | 0.0000 | 0.0026 | 0.0013 | 0.0110 | 0.0272 | 0.0725 | 0.1146 | 0.0881 | 0.1075 | 0.5751 | 27 | 59 | 91 | 117 | 149 | 197 | 277 | 373 | 502 | 0.0056 | 39.72 | 6.385 | 0.3525 | 84287.2 | 43400000 | 26300000000 | 17700000000000 | 0.5008 | 0.1648 | 0.0367 | 0.0032 | 0.1371 | 0.0092 | 0.2234 | 0.0566 | 0.1856 | 0.1095 | 0.1607 | 0.1802 | 0.1201 | 0.1909 | 0.0615 | 0.1404 | 0.0434 | 0.1268 | 0.0316 | 0.1831 | 0.0010 | 0.0008 | 0.0021 | 0.0015 | 0.0046 | 0.0040 | 0.0193 | 0.0143 | 0.0618 | 0.0534 | 0.0900 | 0.0837 | 0.0683 | 0.0638 | 0.1015 | 0.0908 | 0.6515 | 0.6878 | 0.0004 | 0.0008 | 0.0007 | 0.0042 | 0.0048 | 0.0124 | 0.0253 | 0.0287 | 0.0830 | 0.0944 | 0.1247 | 0.1404 | 0.1000 | 0.1138 | 0.1419 | 0.1548 | 0.5192 | 0.4506 | 0.0006 | 0.0023 | 0.0015 | 0.0250 | 0.0581 | 0.1139 | 0.0806 | 0.1154 | 0.6027 |
| MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 706 | 476 | | 728 | 1022 | 96.1 | 32.97 | 217.29 | 252.33 | 64 | 70 | 76 | 81 | 87 | 93 | 104 | 119 | 143 | 0.2652 | 271 | 0.410 | 145.45 | 41.40 | 1 | 0.7843 | 571 | 0.0039 | 22.73 | 5.781 | 0.2516 | 10321.1 | 1250000 | 169000000 | 25300000000 | 0.4351 | 0.2119 | 0.0000 | 0.0000 | 0.0173 | 0.0066 | 0.0202 | 0.0099 | 0.0980 | 0.0066 | 0.2161 | 0.0724 | 0.2017 | 0.0938 | 0.2017 | 0.0674 | 0.1441 | 0.1628 | 0.1009 | 0.5806 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0020 | 0.0000 | 0.0296 | 0.0029 | 0.1006 | 0.0471 | 0.1381 | 0.0799 | 0.1282 | 0.0428 | 0.1440 | 0.1084 | 0.4576 | 0.7190 | 0.0000 | 0.0215 | 0.0000 | 0.0000 | 0.0375 | 0.0000 | 0.0625 | 0.0753 | 0.1438 | 0.1183 | 0.1563 | 0.1720 | 0.1063 | 0.2151 | 0.1438 | 0.1398 | 0.3500 | 0.2581 | 0.0037 | 0.0000 | 0.0112 | 0.0669 | 0.1227 | 0.1450 | 0.0558 | 0.1004 | 0.4944 | 18 | 22 | 28 | 45 | 88 | 168 | 297 | 431 | 602 | 0.0497 | 49.53 | 4.975 | 0.4355 | 110822.0 | 73200000 | 55400000000 | 45800000000000 | 0.5813 | 0.0827 | 0.1029 | 0.0000 | 0.2500 | 0.0581 | 0.3971 | 0.1806 | 0.1324 | 0.2581 | 0.0735 | 0.2387 | 0.0147 | 0.1355 | 0.0294 | 0.0774 | 0.0000 | 0.0387 | 0.0000 | 0.0129 | 0.0000 | 0.0000 | 0.0050 | 0.0022 | 0.0074 | 0.0022 | 0.0074 | 0.0285 | 0.0695 | 0.0724 | 0.1390 | 0.1162 | 0.0893 | 0.0943 | 0.1216 | 0.1250 | 0.5608 | 0.5592 | 0.0000 | 0.0000 | 0.0000 | 0.0033 | 0.0090 | 0.0000 | 0.0090 | 0.0233 | 0.0746 | 0.0731 | 0.1731 | 0.1728 | 0.0836 | 0.1163 | 0.1313 | 0.1262 | 0.5194 | 0.4851 | 0.0000 | 0.0000 | 0.0028 | 0.0110 | 0.0579 | 0.1818 | 0.0661 | 0.1350 | 0.5455 |