High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
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| Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
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| Hs 578T | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 380 | 140 | | 4015 | 11442 | 298.5 | 93.89 | 283.49 | 327.91 | 188 | 224 | 248 | 270 | 290 | 313 | 337 | 371 | 423 | 0.0718 | 821 | 0.641 | 110.89 | 16.16 | 3 | 0.0590 | 237 | 0.0005 | 119.77 | 7.721 | 0.1137 | 97912.3 | 34900000 | 13400000000 | 5490000000000 | 0.4228 | 0.1994 | 0.0000 | 0.0000 | 0.0005 | 0.0003 | 0.0078 | 0.0000 | 0.0352 | 0.0049 | 0.0906 | 0.0391 | 0.1684 | 0.0564 | 0.1361 | 0.0524 | 0.1522 | 0.0795 | 0.4092 | 0.7675 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0020 | 0.0000 | 0.0135 | 0.0016 | 0.0347 | 0.0237 | 0.0663 | 0.0307 | 0.0579 | 0.0234 | 0.0710 | 0.0373 | 0.7547 | 0.8833 | 0.0011 | 0.0093 | 0.0032 | 0.0023 | 0.0086 | 0.0163 | 0.0452 | 0.0629 | 0.0893 | 0.0979 | 0.1453 | 0.1375 | 0.0969 | 0.1235 | 0.1163 | 0.1142 | 0.4941 | 0.4359 | 0.0005 | 0.0005 | 0.0032 | 0.0244 | 0.0684 | 0.1087 | 0.0976 | 0.1124 | 0.5843 | 18 | 23 | 31 | 69 | 150 | 246 | 370 | 532 | 762 | 0.0260 | 64.88 | 6.232 | 0.4074 | 187886.0 | 166000000 | 173000000000 | 201000000000000 | 0.6183 | 0.1150 | 0.0315 | 0.0018 | 0.0954 | 0.0093 | 0.2028 | 0.0466 | 0.1778 | 0.0888 | 0.1759 | 0.1607 | 0.1389 | 0.1793 | 0.0880 | 0.1474 | 0.0528 | 0.1482 | 0.0370 | 0.2179 | 0.0008 | 0.0000 | 0.0015 | 0.0004 | 0.0054 | 0.0022 | 0.0149 | 0.0104 | 0.0492 | 0.0440 | 0.0677 | 0.0593 | 0.0620 | 0.0557 | 0.0989 | 0.0825 | 0.6996 | 0.7454 | 0.0014 | 0.0000 | 0.0038 | 0.0019 | 0.0049 | 0.0074 | 0.0181 | 0.0211 | 0.0585 | 0.0692 | 0.0937 | 0.0977 | 0.0766 | 0.0922 | 0.1110 | 0.1151 | 0.6320 | 0.5954 | 0.0005 | 0.0026 | 0.0062 | 0.0133 | 0.0554 | 0.0778 | 0.0700 | 0.1011 | 0.6730 |
| MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 536 | 592 | | 11784 | 41678 | 115.6 | 34.59 | 207.83 | 214.61 | 75 | 86 | 94 | 103 | 111 | 120 | 130 | 144 | 163 | 0.0416 | 1732 | 0.727 | 154.55 | 39.40 | 3 | 0.0386 | 455 | 0.0021 | 19.63 | 6.518 | 0.2766 | 14550.8 | 1990000 | 293000000 | 46400000000 | 0.4899 | 0.1699 | 0.0021 | 0.0004 | 0.0048 | 0.0007 | 0.0141 | 0.0032 | 0.0416 | 0.0077 | 0.1062 | 0.0329 | 0.1621 | 0.0738 | 0.1591 | 0.0708 | 0.1647 | 0.0991 | 0.3453 | 0.7113 | 0.0007 | 0.0001 | 0.0018 | 0.0005 | 0.0040 | 0.0013 | 0.0122 | 0.0039 | 0.0406 | 0.0176 | 0.0687 | 0.0392 | 0.0628 | 0.0280 | 0.0796 | 0.0464 | 0.7295 | 0.8631 | 0.0022 | 0.0025 | 0.0041 | 0.0115 | 0.0137 | 0.0329 | 0.0504 | 0.0873 | 0.1067 | 0.1853 | 0.1530 | 0.1919 | 0.1278 | 0.1227 | 0.1467 | 0.1524 | 0.3956 | 0.2133 | 0.0013 | 0.0036 | 0.0085 | 0.0266 | 0.0690 | 0.1142 | 0.0929 | 0.1140 | 0.5699 | 15 | 20 | 37 | 80 | 139 | 203 | 278 | 375 | 515 | 0.0215 | 74.38 | 6.685 | 0.3397 | 89248.9 | 51000000 | 34800000000 | 27200000000000 | 0.4252 | 0.2362 | 0.0235 | 0.0012 | 0.1173 | 0.0073 | 0.2179 | 0.0568 | 0.1485 | 0.1081 | 0.1623 | 0.1648 | 0.1467 | 0.2023 | 0.0826 | 0.1340 | 0.0615 | 0.1331 | 0.0396 | 0.1923 | 0.0003 | 0.0001 | 0.0006 | 0.0004 | 0.0028 | 0.0018 | 0.0089 | 0.0066 | 0.0493 | 0.0407 | 0.0985 | 0.0784 | 0.0722 | 0.0592 | 0.0927 | 0.0831 | 0.6748 | 0.7298 | 0.0013 | 0.0008 | 0.0022 | 0.0025 | 0.0046 | 0.0081 | 0.0169 | 0.0211 | 0.0664 | 0.0802 | 0.1232 | 0.1307 | 0.0875 | 0.0958 | 0.1112 | 0.1158 | 0.5867 | 0.5449 | 0.0005 | 0.0023 | 0.0051 | 0.0144 | 0.0596 | 0.1114 | 0.0778 | 0.1061 | 0.6229 |
| MDA-MB-231 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 637 | 251 | | 4831 | 6157 | 434.9 | 144.34 | 87.99 | 128.76 | 226 | 293 | 353 | 413 | 455 | 489 | 520 | 554 | 622 | 0.1176 | 724 | 0.741 | 143.63 | 44.91 | 2 | 0.0909 | 439 | 0.0009 | 28.38 | 7.266 | 0.2359 | 209951.0 | 109000000 | 59200000000 | 33500000000000 | 0.3927 | 0.2352 | 0.0015 | 0.0000 | 0.0035 | 0.0000 | 0.0050 | 0.0003 | 0.0179 | 0.0042 | 0.0601 | 0.0282 | 0.1118 | 0.0434 | 0.0860 | 0.0299 | 0.1143 | 0.0511 | 0.5999 | 0.8429 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0003 | 0.0002 | 0.0023 | 0.0022 | 0.0216 | 0.0210 | 0.0347 | 0.0259 | 0.0213 | 0.0213 | 0.0361 | 0.0291 | 0.8835 | 0.9002 | 0.0007 | 0.0000 | 0.0035 | 0.0000 | 0.0084 | 0.0000 | 0.0169 | 0.0000 | 0.0443 | 0.0000 | 0.0718 | 0.0000 | 0.0577 | 0.0000 | 0.0809 | 0.0000 | 0.7157 | 1.0000 | 0.0000 | 0.0007 | 0.0011 | 0.0048 | 0.0257 | 0.0432 | 0.0313 | 0.0555 | 0.8375 | 9 | 11 | 13 | 18 | 26 | 42 | 87 | 147 | 262 | 0.1247 | 11.17 | 3.769 | 0.6386 | 24317.8 | 10200000 | 5220000000 | 3080000000000 | 0.5729 | 0.1008 | 0.0398 | 0.0089 | 0.1273 | 0.0316 | 0.1777 | 0.0671 | 0.1751 | 0.0886 | 0.1565 | 0.1696 | 0.1008 | 0.1810 | 0.0955 | 0.1405 | 0.0822 | 0.1329 | 0.0451 | 0.1797 | 0.0005 | 0.0004 | 0.0020 | 0.0027 | 0.0025 | 0.0027 | 0.0094 | 0.0093 | 0.0480 | 0.0409 | 0.0762 | 0.0721 | 0.0574 | 0.0503 | 0.0826 | 0.0730 | 0.7216 | 0.7486 | 0.0000 | 0.0007 | 0.0018 | 0.0000 | 0.0030 | 0.0048 | 0.0152 | 0.0213 | 0.0626 | 0.0810 | 0.1027 | 0.1071 | 0.0699 | 0.1009 | 0.1240 | 0.1263 | 0.6207 | 0.5580 | 0.0000 | 0.0005 | 0.0016 | 0.0114 | 0.0565 | 0.0864 | 0.0549 | 0.1010 | 0.6877 |
| Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 438 | 881 | | 789 | 8063 | 74.1 | 31.85 | 47.97 | 131.71 | 30 | 40 | 55 | 65 | 73 | 81 | 92 | 101 | 116 | 0.0633 | 510 | 0.386 | 127.58 | 22.47 | 2 | 0.5982 | 472 | 0.0024 | 38.72 | 6.180 | 0.1858 | 6504.0 | 641928 | 68900000 | 7880000000 | 0.3632 | 0.2507 | 0.0000 | 0.0000 | 0.0038 | 0.0000 | 0.0538 | 0.0043 | 0.1000 | 0.0172 | 0.2115 | 0.0948 | 0.1808 | 0.1401 | 0.1846 | 0.1185 | 0.1692 | 0.1789 | 0.0962 | 0.4461 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0135 | 0.0049 | 0.0558 | 0.0395 | 0.0673 | 0.0543 | 0.0635 | 0.0329 | 0.0885 | 0.0625 | 0.7115 | 0.8059 | 0.0000 | 0.0000 | 0.0154 | 0.0139 | 0.0077 | 0.0625 | 0.0346 | 0.0694 | 0.0962 | 0.1319 | 0.1269 | 0.1667 | 0.1038 | 0.1528 | 0.1692 | 0.1250 | 0.4462 | 0.2778 | 0.0026 | 0.0000 | 0.0026 | 0.0179 | 0.0742 | 0.0818 | 0.1023 | 0.1560 | 0.5627 | 11 | 13 | 15 | 16 | 18 | 20 | 22 | 26 | 61 | 0.4823 | 4.88 | 1.769 | 0.8585 | 19647.5 | 17700000 | 20000000000 | 25500000000000 | 0.6771 | 0.1020 | 0.0533 | 0.0311 | 0.1557 | 0.0251 | 0.2172 | 0.0621 | 0.2377 | 0.0932 | 0.2008 | 0.1657 | 0.0820 | 0.2027 | 0.0287 | 0.1686 | 0.0164 | 0.1198 | 0.0082 | 0.1317 | 0.0000 | 0.0147 | 0.0009 | 0.0077 | 0.0046 | 0.0105 | 0.0352 | 0.0252 | 0.0897 | 0.0617 | 0.1175 | 0.0870 | 0.1027 | 0.1024 | 0.1036 | 0.1080 | 0.5458 | 0.5827 | 0.0012 | 0.0013 | 0.0036 | 0.0027 | 0.0060 | 0.0080 | 0.0239 | 0.0213 | 0.1004 | 0.1120 | 0.1470 | 0.1600 | 0.1016 | 0.0973 | 0.1147 | 0.1307 | 0.5018 | 0.4667 | 0.0000 | 0.0011 | 0.0074 | 0.0253 | 0.1077 | 0.1267 | 0.0940 | 0.1109 | 0.5269 |
| BT-20 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 634 | 836 | | 6694 | 23123 | 220.1 | 45.92 | 161.99 | 175.74 | 165 | 181 | 193 | 204 | 215 | 227 | 240 | 256 | 280 | 0.0480 | 1111 | 1.210 | 102.65 | 44.29 | 1 | 0.0420 | 281 | 0.0011 | 40.91 | 7.097 | 0.1838 | 50535.0 | 12100000 | 3040000000 | 797000000000 | 0.4401 | 0.2135 | 0.0002 | 0.0000 | 0.0007 | 0.0000 | 0.0029 | 0.0002 | 0.0159 | 0.0003 | 0.0615 | 0.0172 | 0.1197 | 0.0311 | 0.1488 | 0.0369 | 0.1834 | 0.0515 | 0.4669 | 0.8628 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0014 | 0.0000 | 0.0062 | 0.0000 | 0.0277 | 0.0126 | 0.0551 | 0.0171 | 0.0627 | 0.0163 | 0.0885 | 0.0249 | 0.7582 | 0.9291 | 0.0046 | 0.0108 | 0.0147 | 0.0179 | 0.0394 | 0.0502 | 0.0879 | 0.1613 | 0.1319 | 0.1613 | 0.1712 | 0.1864 | 0.1071 | 0.1111 | 0.1328 | 0.0932 | 0.3104 | 0.2079 | 0.0013 | 0.0016 | 0.0090 | 0.0303 | 0.0940 | 0.1211 | 0.1137 | 0.1523 | 0.4767 | 11 | 13 | 18 | 38 | 92 | 162 | 235 | 308 | 417 | 0.0450 | 24.09 | 5.615 | 0.4490 | 57122.6 | 25900000 | 13700000000 | 8060000000000 | 0.4415 | 0.1960 | 0.0450 | 0.0017 | 0.1921 | 0.0096 | 0.3192 | 0.0939 | 0.1711 | 0.1707 | 0.1124 | 0.2071 | 0.0816 | 0.1996 | 0.0401 | 0.1194 | 0.0308 | 0.1084 | 0.0078 | 0.0896 | 0.0005 | 0.0001 | 0.0009 | 0.0005 | 0.0008 | 0.0016 | 0.0092 | 0.0074 | 0.0453 | 0.0386 | 0.0833 | 0.0715 | 0.0621 | 0.0516 | 0.0918 | 0.0767 | 0.7061 | 0.7520 | 0.0001 | 0.0007 | 0.0010 | 0.0017 | 0.0034 | 0.0074 | 0.0198 | 0.0214 | 0.0603 | 0.0717 | 0.1056 | 0.1113 | 0.0810 | 0.0864 | 0.1068 | 0.1131 | 0.6220 | 0.5862 | 0.0001 | 0.0006 | 0.0018 | 0.0130 | 0.0555 | 0.0911 | 0.0731 | 0.1019 | 0.6628 |
| MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 309 | 735 | | 1819 | 14901 | 73.2 | 15.19 | 136.21 | 157.45 | 56 | 62 | 65 | 67 | 70 | 74 | 79 | 85 | 94 | 0.0571 | 851 | 0.961 | 66.85 | 20.22 | 3 | 0.0995 | 181 | 0.0042 | 13.83 | 5.799 | 0.2858 | 5584.7 | 444991 | 37000000 | 3220000000 | 0.5015 | 0.1554 | 0.0008 | 0.0000 | 0.0047 | 0.0006 | 0.0228 | 0.0012 | 0.0417 | 0.0140 | 0.1133 | 0.0450 | 0.1707 | 0.1040 | 0.1526 | 0.0900 | 0.1794 | 0.1244 | 0.3139 | 0.6209 | 0.0000 | 0.0000 | 0.0013 | 0.0006 | 0.0069 | 0.0011 | 0.0202 | 0.0117 | 0.0656 | 0.0362 | 0.1040 | 0.0841 | 0.0807 | 0.0523 | 0.1230 | 0.0885 | 0.5984 | 0.7255 | 0.0095 | 0.0238 | 0.0063 | 0.0357 | 0.0381 | 0.1190 | 0.1175 | 0.2381 | 0.1460 | 0.1905 | 0.2190 | 0.1429 | 0.1238 | 0.0833 | 0.1143 | 0.0833 | 0.2254 | 0.0833 | 0.0025 | 0.0135 | 0.0197 | 0.0492 | 0.1095 | 0.1365 | 0.1267 | 0.1501 | 0.3924 | 14 | 17 | 23 | 40 | 73 | 110 | 160 | 243 | 367 | 0.0319 | 18.03 | 5.311 | 0.4923 | 43340.4 | 19300000 | 10300000000 | 6180000000000 | 0.4512 | 0.1992 | 0.0348 | 0.0006 | 0.1211 | 0.0135 | 0.2124 | 0.0737 | 0.1696 | 0.0995 | 0.1621 | 0.1575 | 0.1286 | 0.1894 | 0.0776 | 0.1317 | 0.0547 | 0.1357 | 0.0391 | 0.1983 | 0.0008 | 0.0000 | 0.0012 | 0.0006 | 0.0050 | 0.0021 | 0.0163 | 0.0107 | 0.0553 | 0.0478 | 0.0947 | 0.0811 | 0.0696 | 0.0552 | 0.0962 | 0.0929 | 0.6610 | 0.7096 | 0.0009 | 0.0008 | 0.0018 | 0.0024 | 0.0075 | 0.0050 | 0.0218 | 0.0214 | 0.0693 | 0.0833 | 0.1160 | 0.1303 | 0.0869 | 0.0844 | 0.1141 | 0.1295 | 0.5816 | 0.5430 | 0.0008 | 0.0010 | 0.0031 | 0.0189 | 0.0617 | 0.1060 | 0.0742 | 0.1094 | 0.6249 |
| BT-20 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 825 | 684 | | 7651 | 20186 | 434.9 | 80.92 | 100.21 | 97.16 | 337 | 366 | 390 | 409 | 429 | 448 | 471 | 501 | 545 | 0.0502 | 1013 | 1.138 | 102.84 | 33.06 | 1 | 0.0322 | 246 | 0.0009 | 43.02 | 7.234 | 0.1788 | 195716.0 | 91000000 | 43700000000 | 21700000000000 | 0.4528 | 0.2044 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0013 | 0.0003 | 0.0109 | 0.0004 | 0.0464 | 0.0156 | 0.1085 | 0.0248 | 0.1193 | 0.0267 | 0.1502 | 0.0416 | 0.5632 | 0.8906 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0006 | 0.0000 | 0.0047 | 0.0004 | 0.0241 | 0.0132 | 0.0533 | 0.0176 | 0.0554 | 0.0141 | 0.0757 | 0.0217 | 0.7862 | 0.9330 | 0.0026 | 0.0221 | 0.0123 | 0.0608 | 0.0202 | 0.0663 | 0.0792 | 0.1381 | 0.1206 | 0.1547 | 0.1637 | 0.1381 | 0.1021 | 0.1105 | 0.1144 | 0.1050 | 0.3847 | 0.2044 | 0.0011 | 0.0050 | 0.0089 | 0.0319 | 0.0727 | 0.1248 | 0.1040 | 0.1262 | 0.5255 | 9 | 12 | 22 | 46 | 73 | 101 | 133 | 177 | 238 | 0.0261 | 11.79 | 5.435 | 0.4724 | 19482.1 | 5010000 | 1530000000 | 533000000000 | 0.4602 | 0.1900 | 0.0169 | 0.0009 | 0.0928 | 0.0052 | 0.1893 | 0.0424 | 0.1626 | 0.0894 | 0.1630 | 0.1492 | 0.1587 | 0.1861 | 0.0954 | 0.1402 | 0.0745 | 0.1464 | 0.0468 | 0.2402 | 0.0006 | 0.0001 | 0.0007 | 0.0006 | 0.0017 | 0.0015 | 0.0093 | 0.0072 | 0.0425 | 0.0340 | 0.0820 | 0.0612 | 0.0679 | 0.0521 | 0.0976 | 0.0811 | 0.6977 | 0.7621 | 0.0009 | 0.0007 | 0.0013 | 0.0023 | 0.0028 | 0.0042 | 0.0180 | 0.0214 | 0.0688 | 0.0820 | 0.1143 | 0.1324 | 0.0930 | 0.0958 | 0.1199 | 0.1291 | 0.5810 | 0.5321 | 0.0007 | 0.0011 | 0.0034 | 0.0138 | 0.0527 | 0.0963 | 0.0820 | 0.1141 | 0.6359 | ||
| BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 343 | 266 | | 9188 | 10970 | 380.5 | 50.11 | 368.80 | 331.03 | 317 | 338 | 353 | 366 | 379 | 392 | 407 | 423 | 446 | 0.0837 | 918 | 1.098 | 128.97 | 29.02 | 1 | 0.0293 | 269 | 0.0014 | 32.93 | 6.904 | 0.2140 | 147263.0 | 58000000 | 23200000000 | 9410000000000 | 0.4808 | 0.1754 | 0.0001 | 0.0000 | 0.0001 | 0.0000 | 0.0005 | 0.0000 | 0.0047 | 0.0002 | 0.0250 | 0.0095 | 0.0514 | 0.0210 | 0.0529 | 0.0104 | 0.0987 | 0.0165 | 0.7665 | 0.9424 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0012 | 0.0001 | 0.0138 | 0.0095 | 0.0278 | 0.0207 | 0.0261 | 0.0093 | 0.0415 | 0.0143 | 0.8895 | 0.9462 | 0.0218 | 0.0000 | 0.0328 | 0.0000 | 0.0593 | 0.0000 | 0.0874 | 0.0000 | 0.1732 | 0.0000 | 0.1841 | 0.0000 | 0.1435 | 0.0000 | 0.1388 | 0.0000 | 0.1591 | 0.0000 | 0.0011 | 0.0040 | 0.0097 | 0.0303 | 0.0725 | 0.1067 | 0.1129 | 0.1309 | 0.5320 | 26 | 44 | 103 | 182 | 274 | 391 | 529 | 679 | 850 | 0.0115 | 87.23 | 6.899 | 0.3039 | 245585.0 | 203000000 | 190000000000 | 195000000000000 | 0.5450 | 0.1332 | 0.0240 | 0.0019 | 0.1159 | 0.0052 | 0.2589 | 0.0480 | 0.1785 | 0.1152 | 0.1414 | 0.1989 | 0.1291 | 0.2063 | 0.0765 | 0.1279 | 0.0433 | 0.1290 | 0.0325 | 0.1677 | 0.0004 | 0.0003 | 0.0015 | 0.0005 | 0.0044 | 0.0031 | 0.0158 | 0.0085 | 0.0472 | 0.0440 | 0.0846 | 0.0769 | 0.0584 | 0.0516 | 0.0824 | 0.0766 | 0.7053 | 0.7384 | 0.0003 | 0.0009 | 0.0025 | 0.0032 | 0.0058 | 0.0059 | 0.0156 | 0.0215 | 0.0666 | 0.0792 | 0.1115 | 0.1340 | 0.0860 | 0.1022 | 0.1267 | 0.1240 | 0.5849 | 0.5290 | 0.0000 | 0.0026 | 0.0050 | 0.0109 | 0.0579 | 0.0934 | 0.0690 | 0.0986 | 0.6626 |
| MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1219 | 611 | | 6727 | 10795 | 500.4 | 87.18 | 61.57 | 164.61 | 389 | 436 | 464 | 484 | 500 | 519 | 539 | 564 | 613 | 0.0766 | 827 | 0.887 | 151.21 | 35.90 | 4 | 0.0523 | 352 | 0.0010 | 40.11 | 7.197 | 0.1973 | 258004.0 | 137000000 | 74100000000 | 41200000000000 | 0.4599 | 0.1961 | 0.0006 | 0.0000 | 0.0008 | 0.0000 | 0.0006 | 0.0000 | 0.0061 | 0.0005 | 0.0334 | 0.0138 | 0.0743 | 0.0305 | 0.0688 | 0.0200 | 0.0981 | 0.0361 | 0.7174 | 0.8992 | 0.0003 | 0.0000 | 0.0003 | 0.0000 | 0.0002 | 0.0000 | 0.0020 | 0.0002 | 0.0203 | 0.0122 | 0.0431 | 0.0268 | 0.0321 | 0.0141 | 0.0475 | 0.0242 | 0.8540 | 0.9226 | 0.0036 | 0.0385 | 0.0109 | 0.0641 | 0.0243 | 0.0256 | 0.0510 | 0.1282 | 0.0875 | 0.2179 | 0.1179 | 0.2179 | 0.0899 | 0.1026 | 0.1118 | 0.1026 | 0.5030 | 0.1026 | 0.0015 | 0.0026 | 0.0100 | 0.0280 | 0.0665 | 0.1130 | 0.0971 | 0.1266 | 0.5546 | 5 | 5 | 7 | 8 | 9 | 10 | 12 | 20 | 145 | 0.3474 | 14.59 | 2.480 | 0.7590 | 30885.0 | 22100000 | 18100000000 | 16500000000000 | 0.6221 | 0.0747 | 0.0404 | 0.0026 | 0.1515 | 0.0289 | 0.2172 | 0.0525 | 0.2071 | 0.1732 | 0.1515 | 0.2310 | 0.1414 | 0.2047 | 0.0505 | 0.1260 | 0.0303 | 0.0866 | 0.0101 | 0.0945 | 0.0000 | 0.0006 | 0.0006 | 0.0030 | 0.0032 | 0.0024 | 0.0121 | 0.0119 | 0.0401 | 0.0351 | 0.0650 | 0.0660 | 0.0510 | 0.0463 | 0.0643 | 0.0564 | 0.7637 | 0.7784 | 0.0000 | 0.0000 | 0.0015 | 0.0015 | 0.0015 | 0.0038 | 0.0175 | 0.0215 | 0.0445 | 0.0445 | 0.0729 | 0.0722 | 0.0590 | 0.0507 | 0.0649 | 0.0753 | 0.7383 | 0.7304 | 0.0000 | 0.0014 | 0.0020 | 0.0143 | 0.0442 | 0.0626 | 0.0558 | 0.0721 | 0.7476 |
| Hs 578T | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 826 | 768 | | 6744 | 16336 | 268.2 | 71.69 | 141.22 | 168.95 | 172 | 220 | 244 | 260 | 275 | 290 | 307 | 325 | 352 | 0.0586 | 958 | 0.774 | 134.30 | 33.11 | 3 | 0.0550 | 371 | 0.0010 | 38.65 | 7.160 | 0.1905 | 77081.5 | 23200000 | 7220000000 | 2320000000000 | 0.3771 | 0.2521 | 0.0002 | 0.0000 | 0.0005 | 0.0000 | 0.0047 | 0.0000 | 0.0202 | 0.0010 | 0.0641 | 0.0201 | 0.1133 | 0.0421 | 0.1271 | 0.0409 | 0.1690 | 0.0603 | 0.5009 | 0.8356 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0022 | 0.0003 | 0.0193 | 0.0134 | 0.0351 | 0.0215 | 0.0430 | 0.0137 | 0.0639 | 0.0228 | 0.8363 | 0.9283 | 0.0020 | 0.0031 | 0.0094 | 0.0282 | 0.0201 | 0.0627 | 0.0602 | 0.1818 | 0.1145 | 0.1567 | 0.1667 | 0.2382 | 0.1245 | 0.1160 | 0.1506 | 0.1097 | 0.3521 | 0.1034 | 0.0005 | 0.0016 | 0.0054 | 0.0231 | 0.0549 | 0.0995 | 0.1012 | 0.1118 | 0.6018 | 11 | 13 | 17 | 33 | 74 | 117 | 174 | 256 | 384 | 0.1123 | 13.02 | 4.544 | 0.6051 | 48483.6 | 23400000 | 14000000000 | 9870000000000 | 0.3529 | 0.3072 | 0.0233 | 0.0006 | 0.0993 | 0.0098 | 0.1771 | 0.0540 | 0.1646 | 0.0816 | 0.1538 | 0.1403 | 0.1514 | 0.1788 | 0.0946 | 0.1438 | 0.0814 | 0.1444 | 0.0545 | 0.2467 | 0.0000 | 0.0000 | 0.0010 | 0.0014 | 0.0024 | 0.0015 | 0.0118 | 0.0068 | 0.0392 | 0.0287 | 0.0668 | 0.0517 | 0.0535 | 0.0373 | 0.0764 | 0.0617 | 0.7488 | 0.8108 | 0.0006 | 0.0011 | 0.0012 | 0.0025 | 0.0052 | 0.0039 | 0.0226 | 0.0215 | 0.0569 | 0.0753 | 0.0967 | 0.1142 | 0.0841 | 0.1007 | 0.1157 | 0.1304 | 0.6171 | 0.5504 | 0.0003 | 0.0014 | 0.0036 | 0.0128 | 0.0544 | 0.0778 | 0.0679 | 0.0958 | 0.6859 |
| Hs 578T | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 702 | 223 | | 941 | 12390 | 79.6 | 29.54 | 182.48 | 238.48 | 36 | 53 | 62 | 72 | 81 | 87 | 96 | 106 | 120 | 0.0553 | 685 | 0.420 | 238.65 | 45.22 | 1 | 0.8013 | 754 | 0.0030 | 21.04 | 6.013 | 0.2638 | 7208.4 | 713221 | 75200000 | 8310000000 | 0.4207 | 0.1971 | 0.0028 | 0.0000 | 0.0140 | 0.0000 | 0.0955 | 0.0016 | 0.1124 | 0.0078 | 0.1376 | 0.0889 | 0.1713 | 0.1404 | 0.1292 | 0.1420 | 0.1573 | 0.1451 | 0.1798 | 0.4743 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0015 | 0.0000 | 0.0077 | 0.0025 | 0.0526 | 0.0406 | 0.0896 | 0.0570 | 0.0526 | 0.0456 | 0.0881 | 0.0646 | 0.7079 | 0.7896 | 0.0000 | 0.0068 | 0.0069 | 0.0000 | 0.0309 | 0.0270 | 0.0378 | 0.1216 | 0.1478 | 0.2027 | 0.1890 | 0.2027 | 0.1168 | 0.1757 | 0.1787 | 0.1622 | 0.2921 | 0.1014 | 0.0000 | 0.0020 | 0.0041 | 0.0244 | 0.0815 | 0.1120 | 0.1303 | 0.1589 | 0.4868 | 13 | 16 | 20 | 30 | 62 | 129 | 225 | 349 | 522 | 0.0743 | 27.27 | 5.116 | 0.5188 | 90166.0 | 64100000 | 58300000000 | 64100000000000 | 0.4933 | 0.1833 | 0.0624 | 0.0027 | 0.1895 | 0.0226 | 0.2793 | 0.1183 | 0.1763 | 0.1656 | 0.1490 | 0.2005 | 0.0876 | 0.1919 | 0.0394 | 0.1156 | 0.0153 | 0.1102 | 0.0011 | 0.0726 | 0.0004 | 0.0002 | 0.0023 | 0.0013 | 0.0047 | 0.0036 | 0.0157 | 0.0126 | 0.0591 | 0.0491 | 0.0882 | 0.0803 | 0.0608 | 0.0573 | 0.0914 | 0.0794 | 0.6774 | 0.7162 | 0.0005 | 0.0015 | 0.0024 | 0.0015 | 0.0061 | 0.0041 | 0.0198 | 0.0215 | 0.0614 | 0.0684 | 0.1002 | 0.1256 | 0.0833 | 0.0902 | 0.1091 | 0.1368 | 0.6172 | 0.5505 | 0.0019 | 0.0029 | 0.0038 | 0.0150 | 0.0588 | 0.0954 | 0.0711 | 0.1004 | 0.6507 |
| MCF7 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 1168 | 424 | | 6546 | 17083 | 401.6 | 88.26 | 135.51 | 179.85 | 299 | 325 | 346 | 367 | 388 | 411 | 439 | 479 | 531 | 0.0520 | 889 | 1.155 | 97.74 | 36.50 | 1 | 0.0390 | 255 | 0.0006 | 73.03 | 7.599 | 0.1457 | 169066.0 | 74500000 | 34300000000 | 16500000000000 | 0.4391 | 0.2054 | 0.0002 | 0.0000 | 0.0010 | 0.0000 | 0.0024 | 0.0003 | 0.0156 | 0.0020 | 0.0721 | 0.0202 | 0.1564 | 0.0399 | 0.1454 | 0.0398 | 0.1652 | 0.0640 | 0.4415 | 0.8338 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0067 | 0.0003 | 0.0328 | 0.0108 | 0.0762 | 0.0234 | 0.0686 | 0.0168 | 0.0916 | 0.0321 | 0.7229 | 0.9166 | 0.0000 | 0.0086 | 0.0056 | 0.0115 | 0.0104 | 0.0576 | 0.0569 | 0.1124 | 0.1018 | 0.1960 | 0.1604 | 0.2219 | 0.1099 | 0.1441 | 0.1299 | 0.1210 | 0.4250 | 0.1268 | 0.0014 | 0.0056 | 0.0112 | 0.0352 | 0.0715 | 0.1141 | 0.0855 | 0.1018 | 0.5738 | 6 | 9 | 12 | 24 | 53 | 96 | 159 | 245 | 398 | 0.0690 | 25.10 | 5.074 | 0.4896 | 50707.9 | 26800000 | 17300000000 | 12900000000000 | 0.5220 | 0.1303 | 0.0750 | 0.0031 | 0.1918 | 0.0288 | 0.2725 | 0.1436 | 0.1472 | 0.1470 | 0.1168 | 0.1845 | 0.0842 | 0.1772 | 0.0566 | 0.1189 | 0.0340 | 0.0954 | 0.0219 | 0.1016 | 0.0002 | 0.0003 | 0.0006 | 0.0001 | 0.0031 | 0.0029 | 0.0159 | 0.0113 | 0.0618 | 0.0534 | 0.1096 | 0.0985 | 0.0694 | 0.0658 | 0.1005 | 0.0962 | 0.6390 | 0.6716 | 0.0004 | 0.0009 | 0.0024 | 0.0025 | 0.0050 | 0.0096 | 0.0203 | 0.0215 | 0.0764 | 0.0900 | 0.1299 | 0.1292 | 0.0772 | 0.0830 | 0.1085 | 0.1212 | 0.5799 | 0.5421 | 0.0004 | 0.0014 | 0.0042 | 0.0152 | 0.0716 | 0.1197 | 0.0695 | 0.1083 | 0.6097 |
| Hs 578T | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 798 | 428 | | 27432 | 45118 | 211.1 | 59.97 | 98.82 | 173.21 | 140 | 162 | 179 | 194 | 208 | 223 | 239 | 258 | 287 | 0.0427 | 1927 | 0.804 | 104.04 | 21.19 | 1 | 0.0082 | 226 | 0.0007 | 43.54 | 7.545 | 0.1862 | 48158.5 | 11800000 | 3050000000 | 838000000000 | 0.4170 | 0.2298 | 0.0009 | 0.0000 | 0.0014 | 0.0001 | 0.0072 | 0.0005 | 0.0254 | 0.0026 | 0.0661 | 0.0188 | 0.1224 | 0.0410 | 0.1361 | 0.0439 | 0.1737 | 0.0674 | 0.4667 | 0.8259 | 0.0003 | 0.0000 | 0.0006 | 0.0000 | 0.0027 | 0.0001 | 0.0072 | 0.0009 | 0.0239 | 0.0093 | 0.0448 | 0.0189 | 0.0494 | 0.0177 | 0.0650 | 0.0292 | 0.8061 | 0.9239 | 0.0049 | 0.0049 | 0.0082 | 0.0175 | 0.0196 | 0.0265 | 0.0469 | 0.0746 | 0.0894 | 0.1169 | 0.1266 | 0.1677 | 0.1090 | 0.1102 | 0.1271 | 0.1250 | 0.4683 | 0.3566 | 0.0014 | 0.0023 | 0.0066 | 0.0227 | 0.0535 | 0.0917 | 0.0877 | 0.1135 | 0.6206 | 10 | 12 | 14 | 16 | 20 | 29 | 54 | 137 | 332 | 0.1819 | 23.17 | 3.891 | 0.6587 | 39767.1 | 24100000 | 17400000000 | 14100000000000 | 0.4082 | 0.2647 | 0.1462 | 0.0039 | 0.3078 | 0.0465 | 0.2795 | 0.2378 | 0.1040 | 0.2151 | 0.0818 | 0.2042 | 0.0463 | 0.1441 | 0.0206 | 0.0647 | 0.0093 | 0.0494 | 0.0046 | 0.0343 | 0.0000 | 0.0000 | 0.0009 | 0.0006 | 0.0015 | 0.0011 | 0.0142 | 0.0095 | 0.0704 | 0.0604 | 0.0987 | 0.0930 | 0.0678 | 0.0551 | 0.1104 | 0.0943 | 0.6360 | 0.6860 | 0.0003 | 0.0000 | 0.0017 | 0.0017 | 0.0033 | 0.0043 | 0.0185 | 0.0216 | 0.0848 | 0.0897 | 0.1211 | 0.1251 | 0.0804 | 0.0863 | 0.1188 | 0.1212 | 0.5710 | 0.5502 | 0.0001 | 0.0006 | 0.0030 | 0.0167 | 0.0751 | 0.1185 | 0.0740 | 0.1117 | 0.6002 |
| SK-BR-3 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1053 | 104 | | 2330 | 7315 | 404.0 | 189.76 | 84.83 | 144.30 | 168 | 214 | 264 | 314 | 375 | 453 | 527 | 592 | 678 | 0.0932 | 682 | 0.598 | 100.02 | 13.89 | 5 | 0.0927 | 216 | 0.0009 | 43.35 | 7.214 | 0.1661 | 199239.0 | 112000000 | 68300000000 | 44000000000000 | 0.3454 | 0.2664 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0079 | 0.0000 | 0.0317 | 0.0172 | 0.1329 | 0.0499 | 0.2341 | 0.0946 | 0.2004 | 0.0851 | 0.1786 | 0.0997 | 0.2143 | 0.6535 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0007 | 0.0000 | 0.0060 | 0.0052 | 0.0268 | 0.0215 | 0.0357 | 0.0302 | 0.0402 | 0.0279 | 0.0462 | 0.0296 | 0.8444 | 0.8857 | 0.0000 | 0.0000 | 0.0000 | 0.0018 | 0.0024 | 0.0000 | 0.0060 | 0.0107 | 0.0441 | 0.0661 | 0.0691 | 0.0946 | 0.0524 | 0.0643 | 0.0799 | 0.1143 | 0.7461 | 0.6482 | 0.0000 | 0.0000 | 0.0000 | 0.0037 | 0.0399 | 0.0463 | 0.0399 | 0.0704 | 0.7998 | 21 | 27 | 31 | 34 | 38 | 44 | 54 | 94 | 219 | 0.1318 | 7.03 | 3.250 | 0.7401 | 28015.3 | 26600000 | 42300000000 | 80500000000000 | 0.5119 | 0.1569 | 0.0219 | 0.0200 | 0.0820 | 0.0234 | 0.1530 | 0.0443 | 0.1995 | 0.0747 | 0.2158 | 0.1354 | 0.1503 | 0.1458 | 0.0956 | 0.1519 | 0.0601 | 0.1632 | 0.0219 | 0.2413 | 0.0028 | 0.0096 | 0.0062 | 0.0104 | 0.0068 | 0.0183 | 0.0186 | 0.0246 | 0.0361 | 0.0445 | 0.0559 | 0.0512 | 0.0514 | 0.0608 | 0.0745 | 0.0908 | 0.7477 | 0.6898 | 0.0000 | 0.0000 | 0.0014 | 0.0032 | 0.0057 | 0.0064 | 0.0135 | 0.0216 | 0.0519 | 0.0632 | 0.0811 | 0.0800 | 0.0597 | 0.0752 | 0.0989 | 0.0992 | 0.6878 | 0.6512 | 0.0000 | 0.0000 | 0.0052 | 0.0181 | 0.0413 | 0.0664 | 0.0529 | 0.0896 | 0.7266 |
| BT-20 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 484 | 784 | | 7556 | 23389 | 282.7 | 59.70 | 166.78 | 196.60 | 210 | 231 | 247 | 262 | 276 | 293 | 311 | 334 | 366 | 0.0490 | 1145 | 1.213 | 102.16 | 38.05 | 1 | 0.0335 | 253 | 0.0006 | 75.57 | 7.614 | 0.1408 | 83467.9 | 25700000 | 8220000000 | 2730000000000 | 0.4316 | 0.2191 | 0.0002 | 0.0003 | 0.0006 | 0.0001 | 0.0020 | 0.0000 | 0.0170 | 0.0010 | 0.0677 | 0.0158 | 0.1511 | 0.0377 | 0.1521 | 0.0373 | 0.1708 | 0.0609 | 0.4384 | 0.8469 | 0.0002 | 0.0000 | 0.0003 | 0.0000 | 0.0010 | 0.0000 | 0.0056 | 0.0004 | 0.0270 | 0.0106 | 0.0679 | 0.0232 | 0.0670 | 0.0160 | 0.0934 | 0.0265 | 0.7377 | 0.9233 | 0.0044 | 0.0233 | 0.0110 | 0.0233 | 0.0242 | 0.0631 | 0.0696 | 0.1728 | 0.1275 | 0.1960 | 0.1758 | 0.2060 | 0.1231 | 0.1063 | 0.1407 | 0.1296 | 0.3238 | 0.0797 | 0.0012 | 0.0035 | 0.0092 | 0.0372 | 0.0773 | 0.1330 | 0.1108 | 0.1304 | 0.4975 | 13 | 15 | 19 | 28 | 65 | 144 | 233 | 329 | 451 | 0.0382 | 38.04 | 5.638 | 0.4378 | 66466.3 | 34900000 | 21500000000 | 14900000000000 | 0.4729 | 0.1465 | 0.0850 | 0.0014 | 0.2309 | 0.0230 | 0.3225 | 0.1754 | 0.1274 | 0.1961 | 0.0928 | 0.2081 | 0.0531 | 0.1530 | 0.0330 | 0.0985 | 0.0279 | 0.0639 | 0.0274 | 0.0806 | 0.0000 | 0.0000 | 0.0005 | 0.0004 | 0.0009 | 0.0009 | 0.0084 | 0.0061 | 0.0473 | 0.0406 | 0.0840 | 0.0716 | 0.0667 | 0.0537 | 0.1009 | 0.0862 | 0.6912 | 0.7406 | 0.0001 | 0.0001 | 0.0013 | 0.0011 | 0.0031 | 0.0056 | 0.0161 | 0.0217 | 0.0677 | 0.0724 | 0.1058 | 0.1268 | 0.0903 | 0.0954 | 0.1290 | 0.1366 | 0.5867 | 0.5403 | 0.0000 | 0.0011 | 0.0013 | 0.0122 | 0.0536 | 0.0968 | 0.0807 | 0.1121 | 0.6423 |
| MDA-MB-231 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 305 | 753 | | 14531 | 31502 | 446.4 | 61.03 | 117.13 | 162.48 | 365 | 402 | 424 | 439 | 452 | 464 | 476 | 491 | 515 | 0.0488 | 1538 | 0.844 | 110.02 | 27.80 | 4 | 0.0189 | 274 | 0.0017 | 18.96 | 6.823 | 0.2707 | 202963.0 | 93800000 | 44000000000 | 21000000000000 | 0.4307 | 0.2135 | 0.0003 | 0.0001 | 0.0001 | 0.0000 | 0.0009 | 0.0000 | 0.0036 | 0.0001 | 0.0149 | 0.0077 | 0.0284 | 0.0166 | 0.0253 | 0.0080 | 0.0383 | 0.0128 | 0.8882 | 0.9547 | 0.0001 | 0.0001 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0019 | 0.0001 | 0.0098 | 0.0077 | 0.0186 | 0.0166 | 0.0149 | 0.0080 | 0.0188 | 0.0117 | 0.9360 | 0.9558 | 0.0148 | 1.0000 | 0.0239 | 0.0000 | 0.0091 | 0.0000 | 0.0262 | 0.0000 | 0.0809 | 0.0000 | 0.0945 | 0.0000 | 0.0809 | 0.0000 | 0.1173 | 0.0000 | 0.5524 | 0.0000 | 0.0022 | 0.0070 | 0.0123 | 0.0187 | 0.0346 | 0.0523 | 0.0642 | 0.0921 | 0.7167 | 13 | 16 | 21 | 33 | 52 | 79 | 118 | 180 | 305 | 0.0400 | 19.55 | 4.937 | 0.5597 | 40119.5 | 22800000 | 16800000000 | 14600000000000 | 0.4801 | 0.1897 | 0.0180 | 0.0019 | 0.0684 | 0.0102 | 0.1417 | 0.0304 | 0.1389 | 0.0605 | 0.1660 | 0.1385 | 0.1648 | 0.1775 | 0.1107 | 0.1263 | 0.1041 | 0.1394 | 0.0873 | 0.3154 | 0.0012 | 0.0003 | 0.0022 | 0.0020 | 0.0034 | 0.0030 | 0.0115 | 0.0124 | 0.0463 | 0.0387 | 0.0745 | 0.0614 | 0.0495 | 0.0472 | 0.0766 | 0.0656 | 0.7348 | 0.7694 | 0.0005 | 0.0007 | 0.0024 | 0.0020 | 0.0066 | 0.0068 | 0.0187 | 0.0217 | 0.0585 | 0.0622 | 0.0953 | 0.1084 | 0.0633 | 0.0699 | 0.0954 | 0.0979 | 0.6595 | 0.6304 | 0.0004 | 0.0017 | 0.0044 | 0.0151 | 0.0498 | 0.0888 | 0.0599 | 0.0831 | 0.6968 |
| BT-20 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 1060 | 148 | | 9173 | 22344 | 294.9 | 54.87 | 142.27 | 167.42 | 227 | 246 | 262 | 276 | 290 | 304 | 321 | 343 | 371 | 0.0689 | 1540 | 0.872 | 128.71 | 44.38 | 1 | 0.0395 | 362 | 0.0007 | 53.70 | 7.461 | 0.1589 | 89976.7 | 28400000 | 9240000000 | 3100000000000 | 0.4189 | 0.2273 | 0.0002 | 0.0000 | 0.0012 | 0.0000 | 0.0039 | 0.0000 | 0.0119 | 0.0010 | 0.0544 | 0.0105 | 0.1011 | 0.0239 | 0.1296 | 0.0218 | 0.1648 | 0.0345 | 0.5330 | 0.9084 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0013 | 0.0000 | 0.0059 | 0.0002 | 0.0246 | 0.0088 | 0.0420 | 0.0180 | 0.0587 | 0.0104 | 0.0811 | 0.0154 | 0.7860 | 0.9472 | 0.0035 | 0.0359 | 0.0110 | 0.0256 | 0.0311 | 0.0769 | 0.0876 | 0.1487 | 0.1090 | 0.1436 | 0.1739 | 0.1641 | 0.1256 | 0.1128 | 0.1387 | 0.1231 | 0.3195 | 0.1692 | 0.0012 | 0.0047 | 0.0077 | 0.0323 | 0.0798 | 0.1131 | 0.0949 | 0.1254 | 0.5411 | 14 | 17 | 22 | 39 | 72 | 114 | 176 | 260 | 379 | 0.0282 | 29.29 | 5.688 | 0.4480 | 48267.7 | 23800000 | 15100000000 | 12000000000000 | 0.5526 | 0.1273 | 0.0495 | 0.0023 | 0.1676 | 0.0182 | 0.2382 | 0.0872 | 0.1820 | 0.1262 | 0.1201 | 0.1819 | 0.1042 | 0.1777 | 0.0735 | 0.1315 | 0.0360 | 0.1131 | 0.0288 | 0.1618 | 0.0010 | 0.0004 | 0.0013 | 0.0008 | 0.0025 | 0.0027 | 0.0122 | 0.0114 | 0.0574 | 0.0459 | 0.1001 | 0.0810 | 0.0689 | 0.0643 | 0.0971 | 0.0872 | 0.6595 | 0.7063 | 0.0003 | 0.0003 | 0.0007 | 0.0013 | 0.0044 | 0.0053 | 0.0173 | 0.0217 | 0.0820 | 0.0881 | 0.1194 | 0.1360 | 0.0834 | 0.0891 | 0.1164 | 0.1154 | 0.5761 | 0.5428 | 0.0005 | 0.0013 | 0.0029 | 0.0153 | 0.0705 | 0.1085 | 0.0767 | 0.1091 | 0.6152 |
| MCF 10A | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 815 | 163 | | 2938 | 15825 | 562.8 | 165.66 | 10.78 | 7.31 | 288 | 401 | 494 | 571 | 620 | 652 | 677 | 696 | 723 | 0.0577 | 913 | 0.956 | 43.93 | 14.04 | 1 | 0.0388 | 114 | 0.0035 | 13.77 | 6.195 | 0.3459 | 344227.0 | 221000000 | 147000000000 | 100000000000000 | 0.3768 | 0.2427 | 0.0046 | 0.0000 | 0.0069 | 0.0000 | 0.0069 | 0.0004 | 0.0299 | 0.0021 | 0.0851 | 0.0207 | 0.1219 | 0.0435 | 0.0913 | 0.0236 | 0.1296 | 0.0464 | 0.5238 | 0.8632 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0023 | 0.0016 | 0.0213 | 0.0175 | 0.0344 | 0.0358 | 0.0222 | 0.0179 | 0.0376 | 0.0350 | 0.8822 | 0.8921 | 0.0022 | 0.0000 | 0.0078 | 0.0100 | 0.0111 | 0.0200 | 0.0388 | 0.0200 | 0.0543 | 0.0800 | 0.1008 | 0.1300 | 0.1008 | 0.0700 | 0.1274 | 0.1400 | 0.5570 | 0.5300 | 0.0006 | 0.0000 | 0.0000 | 0.0050 | 0.0233 | 0.0417 | 0.0267 | 0.0389 | 0.8639 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 19 | 0.2362 | 0.38 | 1.298 | 0.6613 | 169.5 | 3950.18 | 122472 | 4500000 | 0.5976 | 0.1040 | 0.0323 | 0.0020 | 0.0756 | 0.0106 | 0.1133 | 0.0336 | 0.1438 | 0.0726 | 0.1811 | 0.1062 | 0.1857 | 0.1514 | 0.1597 | 0.2027 | 0.0873 | 0.2334 | 0.0211 | 0.1876 | 0.0202 | 0.0012 | 0.0489 | 0.0067 | 0.0693 | 0.0257 | 0.0868 | 0.0568 | 0.1051 | 0.0848 | 0.1135 | 0.1256 | 0.1228 | 0.1539 | 0.1364 | 0.1840 | 0.2969 | 0.3614 | 0.0929 | 0.0470 | 0.0631 | 0.0212 | 0.0423 | 0.0131 | 0.0317 | 0.0217 | 0.0372 | 0.0359 | 0.0533 | 0.0606 | 0.0451 | 0.0526 | 0.0776 | 0.0773 | 0.5568 | 0.6705 | 0.0675 | 0.0951 | 0.0928 | 0.0982 | 0.0980 | 0.0940 | 0.0648 | 0.0545 | 0.3351 |
| MCF7 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 318 | 872 | | 12186 | 25790 | 350.1 | 84.35 | 180.74 | 231.33 | 250 | 278 | 300 | 319 | 340 | 362 | 386 | 419 | 463 | 0.0459 | 1185 | 1.241 | 90.52 | 37.58 | 1 | 0.0197 | 240 | 0.0006 | 79.84 | 7.705 | 0.1428 | 129698.0 | 50800000 | 21000000000 | 9160000000000 | 0.4637 | 0.1985 | 0.0008 | 0.0000 | 0.0050 | 0.0002 | 0.0093 | 0.0019 | 0.0269 | 0.0039 | 0.0810 | 0.0184 | 0.1487 | 0.0417 | 0.1625 | 0.0489 | 0.1712 | 0.0732 | 0.3947 | 0.8118 | 0.0001 | 0.0000 | 0.0006 | 0.0000 | 0.0020 | 0.0001 | 0.0091 | 0.0003 | 0.0330 | 0.0101 | 0.0662 | 0.0219 | 0.0745 | 0.0199 | 0.0941 | 0.0344 | 0.7203 | 0.9133 | 0.0050 | 0.0088 | 0.0083 | 0.0113 | 0.0190 | 0.0479 | 0.0690 | 0.1614 | 0.1467 | 0.1589 | 0.1789 | 0.2320 | 0.1149 | 0.1236 | 0.1471 | 0.1097 | 0.3112 | 0.1463 | 0.0009 | 0.0031 | 0.0086 | 0.0355 | 0.0810 | 0.1311 | 0.1118 | 0.1336 | 0.4943 | 10 | 15 | 25 | 45 | 80 | 130 | 204 | 324 | 514 | 0.0440 | 29.42 | 5.543 | 0.4890 | 86176.2 | 59000000 | 49700000000 | 48200000000000 | 0.4861 | 0.1546 | 0.0520 | 0.0023 | 0.1701 | 0.0129 | 0.2665 | 0.0966 | 0.1459 | 0.1378 | 0.1201 | 0.1935 | 0.1172 | 0.1886 | 0.0605 | 0.1155 | 0.0372 | 0.1007 | 0.0305 | 0.1521 | 0.0003 | 0.0004 | 0.0012 | 0.0006 | 0.0023 | 0.0023 | 0.0133 | 0.0093 | 0.0591 | 0.0486 | 0.0997 | 0.0816 | 0.0694 | 0.0558 | 0.1037 | 0.0915 | 0.6512 | 0.7099 | 0.0005 | 0.0003 | 0.0007 | 0.0026 | 0.0046 | 0.0032 | 0.0156 | 0.0218 | 0.0784 | 0.0855 | 0.1293 | 0.1333 | 0.0752 | 0.0852 | 0.1163 | 0.1277 | 0.5793 | 0.5404 | 0.0006 | 0.0014 | 0.0033 | 0.0161 | 0.0656 | 0.1205 | 0.0715 | 0.1126 | 0.6084 |
| MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 580 | 433 | | 1493 | 7000 | 280.3 | 39.92 | 26.94 | 45.70 | 230 | 246 | 259 | 269 | 278 | 289 | 298 | 312 | 333 | 0.0730 | 511 | 0.722 | 72.57 | 16.03 | 1 | 0.1092 | 163 | 0.0044 | 8.62 | 5.687 | 0.3499 | 80150.8 | 23400000 | 6950000000 | 2110000000000 | 0.4223 | 0.2148 | 0.0000 | 0.0000 | 0.0008 | 0.0000 | 0.0000 | 0.0000 | 0.0064 | 0.0007 | 0.0385 | 0.0235 | 0.0577 | 0.0450 | 0.0513 | 0.0215 | 0.0810 | 0.0403 | 0.7642 | 0.8690 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0036 | 0.0007 | 0.0246 | 0.0221 | 0.0377 | 0.0442 | 0.0261 | 0.0181 | 0.0399 | 0.0328 | 0.8681 | 0.8821 | 0.0226 | 0.2000 | 0.0150 | 0.2000 | 0.0526 | 0.4000 | 0.0677 | 0.2000 | 0.0602 | 0.0000 | 0.1053 | 0.0000 | 0.0902 | 0.0000 | 0.1278 | 0.0000 | 0.4586 | 0.0000 | 0.0014 | 0.0014 | 0.0069 | 0.0220 | 0.0495 | 0.0755 | 0.0975 | 0.1319 | 0.6140 | 7 | 8 | 9 | 10 | 12 | 15 | 20 | 33 | 57 | 0.2933 | 1.67 | 2.358 | 0.8342 | 2814.2 | 777978 | 343000000 | 188000000000 | 0.6091 | 0.1098 | 0.0437 | 0.0353 | 0.0542 | 0.0453 | 0.0822 | 0.0637 | 0.1014 | 0.0599 | 0.1294 | 0.0860 | 0.1451 | 0.1083 | 0.1521 | 0.1045 | 0.1573 | 0.1421 | 0.1346 | 0.3548 | 0.0065 | 0.0172 | 0.0101 | 0.0192 | 0.0081 | 0.0204 | 0.0141 | 0.0188 | 0.0252 | 0.0337 | 0.0348 | 0.0425 | 0.0403 | 0.0357 | 0.0685 | 0.0665 | 0.7924 | 0.7459 | 0.0035 | 0.0050 | 0.0042 | 0.0084 | 0.0099 | 0.0168 | 0.0156 | 0.0218 | 0.0453 | 0.0536 | 0.0545 | 0.0662 | 0.0630 | 0.0679 | 0.1288 | 0.1274 | 0.6752 | 0.6329 | 0.0024 | 0.0047 | 0.0082 | 0.0141 | 0.0294 | 0.0500 | 0.0488 | 0.1106 | 0.7318 |
| BT-20 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1182 | 506 | | 5215 | 17071 | 251.9 | 54.05 | 103.06 | 163.53 | 180 | 201 | 217 | 233 | 250 | 266 | 282 | 302 | 327 | 0.0592 | 1011 | 1.075 | 113.14 | 33.02 | 1 | 0.0516 | 269 | 0.0008 | 48.54 | 7.272 | 0.1797 | 66392.4 | 18200000 | 5190000000 | 1520000000000 | 0.4330 | 0.2117 | 0.0006 | 0.0000 | 0.0022 | 0.0000 | 0.0048 | 0.0000 | 0.0275 | 0.0022 | 0.0797 | 0.0138 | 0.1232 | 0.0367 | 0.1331 | 0.0359 | 0.1574 | 0.0648 | 0.4715 | 0.8468 | 0.0002 | 0.0000 | 0.0010 | 0.0000 | 0.0010 | 0.0000 | 0.0077 | 0.0012 | 0.0289 | 0.0106 | 0.0534 | 0.0245 | 0.0530 | 0.0168 | 0.0732 | 0.0315 | 0.7817 | 0.9154 | 0.0029 | 0.0373 | 0.0097 | 0.0683 | 0.0165 | 0.0683 | 0.0584 | 0.1739 | 0.1051 | 0.2050 | 0.1907 | 0.1801 | 0.1430 | 0.1180 | 0.1459 | 0.0745 | 0.3278 | 0.0745 | 0.0004 | 0.0027 | 0.0059 | 0.0212 | 0.0550 | 0.1037 | 0.0923 | 0.1127 | 0.6060 | 8 | 10 | 12 | 14 | 19 | 40 | 88 | 178 | 323 | 0.1315 | 17.54 | 4.370 | 0.5904 | 37361.8 | 20200000 | 13400000000 | 10300000000000 | 0.5718 | 0.1052 | 0.0904 | 0.0025 | 0.2461 | 0.0286 | 0.3176 | 0.1880 | 0.1451 | 0.1835 | 0.0925 | 0.1830 | 0.0641 | 0.1810 | 0.0273 | 0.0847 | 0.0137 | 0.0762 | 0.0032 | 0.0727 | 0.0004 | 0.0000 | 0.0008 | 0.0005 | 0.0013 | 0.0015 | 0.0144 | 0.0131 | 0.0649 | 0.0555 | 0.1011 | 0.0975 | 0.0663 | 0.0604 | 0.0930 | 0.0903 | 0.6578 | 0.6812 | 0.0005 | 0.0005 | 0.0016 | 0.0020 | 0.0060 | 0.0048 | 0.0196 | 0.0218 | 0.0670 | 0.0698 | 0.1097 | 0.1043 | 0.0649 | 0.0698 | 0.0947 | 0.0959 | 0.6360 | 0.6311 | 0.0004 | 0.0010 | 0.0042 | 0.0151 | 0.0692 | 0.1025 | 0.0681 | 0.0903 | 0.6491 |
| MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 274 | 223 | | 6457 | 17021 | 77.3 | 19.26 | 210.94 | 213.95 | 57 | 61 | 66 | 70 | 74 | 78 | 84 | 91 | 103 | 0.0644 | 1096 | 0.843 | 90.43 | 26.17 | 1 | 0.0367 | 237 | 0.0028 | 17.12 | 6.228 | 0.2745 | 6348.3 | 556064 | 52200000 | 5250000000 | 0.4510 | 0.1996 | 0.0010 | 0.0000 | 0.0056 | 0.0003 | 0.0133 | 0.0005 | 0.0380 | 0.0061 | 0.0745 | 0.0225 | 0.1425 | 0.0484 | 0.1711 | 0.0522 | 0.2152 | 0.0849 | 0.3389 | 0.7851 | 0.0004 | 0.0000 | 0.0023 | 0.0002 | 0.0068 | 0.0000 | 0.0163 | 0.0020 | 0.0342 | 0.0138 | 0.0671 | 0.0273 | 0.0778 | 0.0218 | 0.1102 | 0.0414 | 0.6848 | 0.8935 | 0.0074 | 0.0130 | 0.0197 | 0.0216 | 0.0303 | 0.0670 | 0.0663 | 0.1058 | 0.1286 | 0.1685 | 0.1335 | 0.1598 | 0.1179 | 0.1102 | 0.1605 | 0.1102 | 0.3358 | 0.2441 | 0.0024 | 0.0094 | 0.0171 | 0.0447 | 0.0765 | 0.1024 | 0.1080 | 0.1279 | 0.5114 | 18 | 30 | 63 | 104 | 145 | 194 | 257 | 356 | 511 | 0.0108 | 28.47 | 6.188 | 0.3938 | 90266.1 | 55800000 | 45300000000 | 46700000000000 | 0.5019 | 0.1685 | 0.0158 | 0.0008 | 0.0801 | 0.0060 | 0.1780 | 0.0286 | 0.1711 | 0.0730 | 0.1885 | 0.1548 | 0.1561 | 0.2064 | 0.0991 | 0.1523 | 0.0752 | 0.1528 | 0.0360 | 0.2253 | 0.0009 | 0.0001 | 0.0013 | 0.0006 | 0.0042 | 0.0030 | 0.0144 | 0.0093 | 0.0568 | 0.0438 | 0.0954 | 0.0772 | 0.0796 | 0.0684 | 0.1057 | 0.0967 | 0.6416 | 0.7008 | 0.0013 | 0.0018 | 0.0031 | 0.0027 | 0.0098 | 0.0098 | 0.0233 | 0.0219 | 0.0729 | 0.0825 | 0.1141 | 0.1324 | 0.0873 | 0.0882 | 0.1187 | 0.1185 | 0.5694 | 0.5421 | 0.0022 | 0.0021 | 0.0062 | 0.0230 | 0.0643 | 0.1045 | 0.0826 | 0.1072 | 0.6079 |
| MDA-MB-231 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 1189 | 733 | | 6368 | 8540 | 460.5 | 95.33 | 276.86 | 365.75 | 341 | 370 | 398 | 426 | 449 | 474 | 509 | 550 | 597 | 0.0848 | 724 | 0.776 | 177.72 | 41.62 | 1 | 0.0785 | 500 | 0.0009 | 23.98 | 7.222 | 0.2306 | 221183.0 | 111000000 | 57400000000 | 30900000000000 | 0.4039 | 0.2350 | 0.0005 | 0.0000 | 0.0020 | 0.0003 | 0.0059 | 0.0005 | 0.0136 | 0.0018 | 0.0358 | 0.0143 | 0.0491 | 0.0278 | 0.0573 | 0.0203 | 0.0893 | 0.0345 | 0.7465 | 0.9005 | 0.0000 | 0.0000 | 0.0010 | 0.0000 | 0.0021 | 0.0000 | 0.0072 | 0.0005 | 0.0145 | 0.0099 | 0.0191 | 0.0206 | 0.0217 | 0.0093 | 0.0320 | 0.0179 | 0.9023 | 0.9419 | 0.0074 | 0.0186 | 0.0017 | 0.0372 | 0.0124 | 0.0558 | 0.0314 | 0.0884 | 0.0553 | 0.1023 | 0.0677 | 0.1395 | 0.0619 | 0.1302 | 0.0958 | 0.1535 | 0.6664 | 0.2744 | 0.0003 | 0.0024 | 0.0069 | 0.0180 | 0.0340 | 0.0506 | 0.0544 | 0.0634 | 0.7698 | 9 | 12 | 16 | 59 | 118 | 196 | 330 | 523 | 797 | 0.0654 | 101.98 | 5.746 | 0.4428 | 210404.0 | 226000000 | 301000000000 | 467000000000000 | 0.4431 | 0.2080 | 0.0250 | 0.0028 | 0.1591 | 0.0106 | 0.2872 | 0.0700 | 0.1944 | 0.1272 | 0.1399 | 0.1965 | 0.1046 | 0.2367 | 0.0442 | 0.1357 | 0.0339 | 0.1074 | 0.0118 | 0.1131 | 0.0000 | 0.0000 | 0.0006 | 0.0011 | 0.0028 | 0.0030 | 0.0130 | 0.0116 | 0.0551 | 0.0462 | 0.0740 | 0.0648 | 0.0688 | 0.0562 | 0.0988 | 0.0759 | 0.6869 | 0.7413 | 0.0008 | 0.0004 | 0.0016 | 0.0026 | 0.0035 | 0.0044 | 0.0208 | 0.0219 | 0.0631 | 0.0804 | 0.1145 | 0.1307 | 0.0922 | 0.0979 | 0.1196 | 0.1281 | 0.5839 | 0.5337 | 0.0000 | 0.0011 | 0.0032 | 0.0151 | 0.0601 | 0.0984 | 0.0766 | 0.1131 | 0.6325 |
| BT-20 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 577 | 529 | | 6874 | 21430 | 274.4 | 54.77 | 116.67 | 134.04 | 206 | 226 | 242 | 256 | 270 | 284 | 301 | 322 | 348 | 0.0497 | 1066 | 0.952 | 129.08 | 32.53 | 1 | 0.0428 | 294 | 0.0008 | 54.60 | 7.392 | 0.1620 | 78288.9 | 23200000 | 7120000000 | 2260000000000 | 0.4124 | 0.2339 | 0.0007 | 0.0000 | 0.0004 | 0.0000 | 0.0024 | 0.0002 | 0.0146 | 0.0009 | 0.0620 | 0.0167 | 0.1265 | 0.0357 | 0.1468 | 0.0339 | 0.1774 | 0.0560 | 0.4691 | 0.8567 | 0.0003 | 0.0000 | 0.0003 | 0.0000 | 0.0009 | 0.0000 | 0.0052 | 0.0007 | 0.0245 | 0.0114 | 0.0505 | 0.0239 | 0.0545 | 0.0147 | 0.0759 | 0.0202 | 0.7879 | 0.9290 | 0.0068 | 0.0346 | 0.0101 | 0.0260 | 0.0245 | 0.1126 | 0.0785 | 0.1472 | 0.1647 | 0.2338 | 0.1976 | 0.1515 | 0.1309 | 0.1126 | 0.1512 | 0.1169 | 0.2356 | 0.0649 | 0.0012 | 0.0000 | 0.0080 | 0.0316 | 0.0807 | 0.1133 | 0.1072 | 0.1308 | 0.5272 | 10 | 13 | 16 | 28 | 55 | 99 | 154 | 222 | 315 | 0.0595 | 13.88 | 5.027 | 0.5286 | 31578.4 | 11600000 | 5190000000 | 2690000000000 | 0.5015 | 0.1536 | 0.0506 | 0.0016 | 0.2117 | 0.0180 | 0.3416 | 0.0886 | 0.1686 | 0.1769 | 0.1002 | 0.2501 | 0.0717 | 0.1846 | 0.0372 | 0.1200 | 0.0151 | 0.0904 | 0.0032 | 0.0698 | 0.0001 | 0.0000 | 0.0006 | 0.0005 | 0.0015 | 0.0008 | 0.0076 | 0.0083 | 0.0547 | 0.0435 | 0.0986 | 0.0770 | 0.0711 | 0.0601 | 0.1113 | 0.0927 | 0.6546 | 0.7171 | 0.0003 | 0.0007 | 0.0017 | 0.0016 | 0.0030 | 0.0034 | 0.0156 | 0.0219 | 0.0765 | 0.0905 | 0.1334 | 0.1420 | 0.0961 | 0.1062 | 0.1363 | 0.1430 | 0.5370 | 0.4906 | 0.0003 | 0.0010 | 0.0023 | 0.0117 | 0.0625 | 0.1168 | 0.0835 | 0.1295 | 0.5924 |
| MCF7 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 367 | 527 | | 14166 | 30978 | 166.3 | 51.48 | 150.74 | 180.13 | 108 | 123 | 136 | 147 | 158 | 171 | 186 | 207 | 241 | 0.0455 | 1410 | 1.186 | 107.56 | 39.85 | 4 | 0.0193 | 274 | 0.0029 | 11.78 | 6.212 | 0.3232 | 30318.4 | 6020000 | 1290000000 | 298000000000 | 0.4567 | 0.2012 | 0.0010 | 0.0002 | 0.0020 | 0.0003 | 0.0095 | 0.0011 | 0.0293 | 0.0063 | 0.0939 | 0.0301 | 0.1627 | 0.0648 | 0.1523 | 0.0591 | 0.1747 | 0.0901 | 0.3747 | 0.7480 | 0.0004 | 0.0000 | 0.0004 | 0.0001 | 0.0027 | 0.0002 | 0.0099 | 0.0021 | 0.0378 | 0.0155 | 0.0638 | 0.0296 | 0.0626 | 0.0267 | 0.0911 | 0.0439 | 0.7313 | 0.8820 | 0.0021 | 0.0018 | 0.0049 | 0.0083 | 0.0147 | 0.0155 | 0.0350 | 0.0596 | 0.0936 | 0.1173 | 0.1393 | 0.1757 | 0.0967 | 0.1203 | 0.1362 | 0.1471 | 0.4774 | 0.3544 | 0.0008 | 0.0034 | 0.0088 | 0.0319 | 0.0709 | 0.1074 | 0.0856 | 0.1046 | 0.5866 | 8 | 10 | 15 | 33 | 75 | 129 | 195 | 283 | 413 | 0.0651 | 14.33 | 5.012 | 0.4997 | 55169.9 | 27400000 | 16300000000 | 11100000000000 | 0.5068 | 0.1638 | 0.0376 | 0.0026 | 0.1800 | 0.0101 | 0.2471 | 0.0930 | 0.1592 | 0.1413 | 0.1404 | 0.1940 | 0.1108 | 0.1938 | 0.0625 | 0.1310 | 0.0393 | 0.1131 | 0.0232 | 0.1211 | 0.0002 | 0.0002 | 0.0005 | 0.0001 | 0.0016 | 0.0012 | 0.0097 | 0.0069 | 0.0522 | 0.0426 | 0.0886 | 0.0730 | 0.0686 | 0.0557 | 0.1054 | 0.0879 | 0.6732 | 0.7326 | 0.0004 | 0.0006 | 0.0015 | 0.0020 | 0.0027 | 0.0051 | 0.0177 | 0.0220 | 0.0740 | 0.0904 | 0.1206 | 0.1278 | 0.0882 | 0.0952 | 0.1271 | 0.1330 | 0.5678 | 0.5239 | 0.0000 | 0.0020 | 0.0028 | 0.0144 | 0.0620 | 0.1077 | 0.0815 | 0.1152 | 0.6146 |