High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
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Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
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MCF7 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 735 | 634 | 3383 | 13602 | 420.5 | 93.73 | 24.16 | 65.07 | 310 | 345 | 369 | 393 | 413 | 435 | 458 | 483 | 531 | 0.0471 | 641 | 0.708 | 187.75 | 42.58 | 1 | 0.1469 | 497 | 0.0008 | 81.64 | 7.362 | 0.1445 | 185607.0 | 86200000 | 42200000000 | 21900000000000 | 0.4414 | 0.2109 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0048 | 0.0000 | 0.0190 | 0.0000 | 0.0557 | 0.0201 | 0.1348 | 0.0447 | 0.1232 | 0.0352 | 0.1517 | 0.0569 | 0.5108 | 0.8430 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0061 | 0.0000 | 0.0327 | 0.0138 | 0.0779 | 0.0312 | 0.0610 | 0.0204 | 0.0832 | 0.0309 | 0.7391 | 0.9038 | 0.0169 | 0.0000 | 0.0127 | 0.0252 | 0.0465 | 0.0377 | 0.0465 | 0.0755 | 0.1269 | 0.1447 | 0.1882 | 0.1698 | 0.0867 | 0.1195 | 0.1501 | 0.1069 | 0.3256 | 0.3208 | 0.0000 | 0.0050 | 0.0126 | 0.0320 | 0.0961 | 0.1420 | 0.1030 | 0.1470 | 0.4623 | 5 | 6 | 7 | 7 | 9 | 10 | 13 | 19 | 43 | 0.1856 | 1.96 | 2.069 | 0.6343 | 4817.1 | 2540000 | 1750000000 | 1330000000000 | 0.5397 | 0.1164 | 0.0580 | 0.0279 | 0.1116 | 0.0343 | 0.1949 | 0.0594 | 0.2024 | 0.1054 | 0.1741 | 0.1577 | 0.1310 | 0.1758 | 0.0759 | 0.1589 | 0.0387 | 0.1368 | 0.0134 | 0.1438 | 0.0052 | 0.0139 | 0.0041 | 0.0154 | 0.0067 | 0.0198 | 0.0191 | 0.0302 | 0.0479 | 0.0395 | 0.0621 | 0.0552 | 0.0592 | 0.0599 | 0.0943 | 0.0738 | 0.7012 | 0.6922 | 0.0010 | 0.0012 | 0.0035 | 0.0035 | 0.0045 | 0.0104 | 0.0205 | 0.0267 | 0.0730 | 0.0818 | 0.0985 | 0.1021 | 0.0725 | 0.0754 | 0.1151 | 0.1155 | 0.6113 | 0.5833 | 0.0026 | 0.0039 | 0.0039 | 0.0176 | 0.0511 | 0.0815 | 0.0686 | 0.1047 | 0.6662 | |
MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 1167 | 689 | 6111 | 11010 | 86.5 | 25.63 | 194.11 | 227.36 | 55 | 64 | 71 | 78 | 84 | 91 | 98 | 107 | 121 | 0.0750 | 826 | 0.733 | 215.47 | 54.20 | 4 | 0.0928 | 567 | 0.0034 | 11.76 | 5.994 | 0.3193 | 8137.3 | 828575 | 90900000 | 10700000000 | 0.4313 | 0.2183 | 0.0010 | 0.0004 | 0.0045 | 0.0006 | 0.0156 | 0.0018 | 0.0448 | 0.0075 | 0.1171 | 0.0342 | 0.1801 | 0.0744 | 0.1674 | 0.0795 | 0.1944 | 0.1213 | 0.2751 | 0.6804 | 0.0004 | 0.0004 | 0.0011 | 0.0000 | 0.0033 | 0.0004 | 0.0100 | 0.0028 | 0.0462 | 0.0179 | 0.0736 | 0.0369 | 0.0694 | 0.0341 | 0.1040 | 0.0529 | 0.6918 | 0.8547 | 0.0057 | 0.0065 | 0.0086 | 0.0161 | 0.0179 | 0.0581 | 0.0622 | 0.1113 | 0.1237 | 0.1597 | 0.1587 | 0.1968 | 0.1244 | 0.1323 | 0.1494 | 0.1419 | 0.3495 | 0.1774 | 0.0020 | 0.0037 | 0.0116 | 0.0317 | 0.0810 | 0.1161 | 0.1045 | 0.1324 | 0.5170 | 14 | 18 | 27 | 51 | 94 | 159 | 248 | 359 | 533 | 0.0198 | 121.90 | 6.448 | 0.3047 | 89366.6 | 55800000 | 41100000000 | 34000000000000 | 0.4757 | 0.1749 | 0.0822 | 0.0030 | 0.2716 | 0.0287 | 0.3153 | 0.2000 | 0.1093 | 0.1713 | 0.1103 | 0.1866 | 0.0562 | 0.1683 | 0.0416 | 0.0896 | 0.0083 | 0.0733 | 0.0052 | 0.0792 | 0.0007 | 0.0002 | 0.0002 | 0.0008 | 0.0034 | 0.0016 | 0.0104 | 0.0093 | 0.0707 | 0.0599 | 0.1227 | 0.1136 | 0.0860 | 0.0717 | 0.1146 | 0.1087 | 0.5914 | 0.6343 | 0.0006 | 0.0007 | 0.0014 | 0.0039 | 0.0046 | 0.0079 | 0.0149 | 0.0201 | 0.0879 | 0.0911 | 0.1479 | 0.1601 | 0.0948 | 0.0999 | 0.1390 | 0.1443 | 0.5088 | 0.4721 | 0.0003 | 0.0018 | 0.0059 | 0.0132 | 0.0749 | 0.1391 | 0.0892 | 0.1302 | 0.5455 | |
MCF7 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 855 | 618 | 6392 | 8692 | 565.9 | 136.42 | 151.51 | 154.48 | 405 | 449 | 487 | 519 | 551 | 583 | 618 | 669 | 747 | 0.0962 | 836 | 1.181 | 149.16 | 56.30 | 1 | 0.0601 | 384 | 0.0005 | 84.49 | 7.736 | 0.1296 | 338887.0 | 215000000 | 144000000000 | 102000000000000 | 0.4381 | 0.2035 | 0.0003 | 0.0000 | 0.0013 | 0.0002 | 0.0021 | 0.0003 | 0.0167 | 0.0026 | 0.0632 | 0.0204 | 0.1182 | 0.0408 | 0.1292 | 0.0333 | 0.1665 | 0.0493 | 0.5027 | 0.8530 | 0.0000 | 0.0000 | 0.0008 | 0.0002 | 0.0008 | 0.0002 | 0.0063 | 0.0016 | 0.0281 | 0.0131 | 0.0505 | 0.0215 | 0.0583 | 0.0156 | 0.0783 | 0.0233 | 0.7769 | 0.9246 | 0.0026 | 0.0102 | 0.0061 | 0.0051 | 0.0104 | 0.0255 | 0.0494 | 0.0561 | 0.1223 | 0.1378 | 0.1405 | 0.2168 | 0.1119 | 0.1173 | 0.1474 | 0.1505 | 0.4094 | 0.2806 | 0.0014 | 0.0034 | 0.0085 | 0.0263 | 0.0650 | 0.1026 | 0.0988 | 0.1173 | 0.5766 | 16 | 30 | 48 | 69 | 98 | 135 | 183 | 254 | 363 | 0.0144 | 28.33 | 5.755 | 0.4071 | 46815.8 | 20900000 | 11800000000 | 7940000000000 | 0.4493 | 0.1881 | 0.0467 | 0.0022 | 0.1642 | 0.0178 | 0.2921 | 0.0975 | 0.1659 | 0.1300 | 0.1366 | 0.1820 | 0.0977 | 0.1971 | 0.0467 | 0.1443 | 0.0285 | 0.1109 | 0.0216 | 0.1183 | 0.0000 | 0.0000 | 0.0016 | 0.0020 | 0.0024 | 0.0004 | 0.0199 | 0.0124 | 0.0749 | 0.0587 | 0.1204 | 0.0974 | 0.0863 | 0.0733 | 0.1178 | 0.1060 | 0.5768 | 0.6498 | 0.0004 | 0.0009 | 0.0008 | 0.0023 | 0.0046 | 0.0072 | 0.0347 | 0.0432 | 0.1206 | 0.1292 | 0.1583 | 0.1567 | 0.0946 | 0.1094 | 0.1389 | 0.1531 | 0.4472 | 0.3980 | 0.0010 | 0.0016 | 0.0035 | 0.0247 | 0.0958 | 0.1380 | 0.0986 | 0.1415 | 0.4954 | |
MCF 10A | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 1200 | 960 | 312 | 3292 | 82.5 | 11.29 | 23.21 | 72.43 | 68 | 73 | 76 | 79 | 82 | 86 | 89 | 93 | 97 | 0.1206 | 397 | 1.136 | 33.29 | 11.66 | 2 | 0.2724 | 85 | 0.0754 | 0.90 | 2.811 | 0.6827 | 6932.2 | 592793 | 51500000 | 4550000000 | 0.3990 | 0.2389 | 0.0037 | 0.0000 | 0.0000 | 0.0032 | 0.0112 | 0.0000 | 0.0485 | 0.0096 | 0.0672 | 0.0737 | 0.1194 | 0.0833 | 0.0933 | 0.0481 | 0.1604 | 0.0705 | 0.4963 | 0.7115 | 0.0034 | 0.0000 | 0.0000 | 0.0032 | 0.0069 | 0.0000 | 0.0206 | 0.0096 | 0.0481 | 0.0737 | 0.0997 | 0.0833 | 0.0378 | 0.0481 | 0.0722 | 0.0705 | 0.7113 | 0.7115 | 0.0870 | 0.0000 | 0.1304 | 0.0000 | 0.2174 | 0.0000 | 0.2609 | 0.0000 | 0.0870 | 0.0000 | 0.1304 | 0.0000 | 0.0435 | 0.0000 | 0.0000 | 0.0000 | 0.0435 | 0.0000 | 0.0120 | 0.0180 | 0.0299 | 0.0539 | 0.0898 | 0.2275 | 0.0958 | 0.1078 | 0.3653 | 5 | 6 | 8 | 8 | 9 | 10 | 11 | 12 | 16 | 0.2788 | 2.99 | 1.539 | 0.6666 | 5783.0 | 2740000 | 1470000000 | 851000000000 | 0.3576 | 0.2571 | 0.1333 | 0.2774 | 0.2167 | 0.1473 | 0.3500 | 0.1130 | 0.1833 | 0.1541 | 0.0833 | 0.1336 | 0.0333 | 0.1199 | 0.0000 | 0.0411 | 0.0000 | 0.0103 | 0.0000 | 0.0034 | 0.0217 | 0.1656 | 0.0072 | 0.0879 | 0.0109 | 0.0573 | 0.0217 | 0.0613 | 0.0435 | 0.0327 | 0.0942 | 0.0675 | 0.0471 | 0.0409 | 0.0870 | 0.0695 | 0.6667 | 0.4172 | 0.0000 | 0.0000 | 0.0093 | 0.0000 | 0.0046 | 0.0000 | 0.0139 | 0.0203 | 0.0509 | 0.0711 | 0.1111 | 0.0863 | 0.0556 | 0.0761 | 0.0787 | 0.0863 | 0.6759 | 0.6599 | 0.0042 | 0.0042 | 0.0211 | 0.0253 | 0.0506 | 0.0717 | 0.0717 | 0.0928 | 0.6582 | |
MDA-MB-231 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 755 | 233 | 6882 | 11035 | 750.8 | 130.11 | 50.30 | 107.22 | 589 | 637 | 676 | 712 | 743 | 780 | 818 | 862 | 917 | 0.0847 | 935 | 0.936 | 120.35 | 37.05 | 2 | 0.0442 | 304 | 0.0010 | 30.30 | 7.224 | 0.2258 | 580634.0 | 462000000 | 378000000000 | 319000000000000 | 0.4407 | 0.2046 | 0.0004 | 0.0000 | 0.0011 | 0.0000 | 0.0019 | 0.0001 | 0.0078 | 0.0003 | 0.0358 | 0.0142 | 0.0524 | 0.0228 | 0.0553 | 0.0152 | 0.0717 | 0.0231 | 0.7735 | 0.9243 | 0.0002 | 0.0000 | 0.0002 | 0.0000 | 0.0002 | 0.0000 | 0.0031 | 0.0003 | 0.0186 | 0.0130 | 0.0277 | 0.0192 | 0.0279 | 0.0119 | 0.0379 | 0.0175 | 0.8843 | 0.9381 | 0.0012 | 0.0000 | 0.0048 | 0.0000 | 0.0203 | 0.0102 | 0.0501 | 0.1122 | 0.0776 | 0.0918 | 0.1241 | 0.1531 | 0.1181 | 0.1122 | 0.1050 | 0.1429 | 0.4988 | 0.3776 | 0.0009 | 0.0021 | 0.0039 | 0.0173 | 0.0318 | 0.0500 | 0.0518 | 0.0760 | 0.7662 | 7 | 9 | 11 | 12 | 15 | 19 | 26 | 42 | 126 | 0.0842 | 13.28 | 3.740 | 0.6597 | 14024.1 | 7570000 | 5380000000 | 4510000000000 | 0.4239 | 0.2208 | 0.0278 | 0.0089 | 0.0872 | 0.0149 | 0.1930 | 0.0343 | 0.1818 | 0.0961 | 0.1781 | 0.1586 | 0.1447 | 0.1571 | 0.1095 | 0.1400 | 0.0538 | 0.1482 | 0.0241 | 0.2420 | 0.0017 | 0.0034 | 0.0022 | 0.0044 | 0.0074 | 0.0065 | 0.0288 | 0.0266 | 0.0616 | 0.0536 | 0.0634 | 0.0615 | 0.0621 | 0.0663 | 0.0743 | 0.0844 | 0.6984 | 0.6933 | 0.0000 | 0.0013 | 0.0011 | 0.0013 | 0.0046 | 0.0019 | 0.0194 | 0.0183 | 0.0549 | 0.0593 | 0.0800 | 0.0732 | 0.0446 | 0.0511 | 0.0652 | 0.0650 | 0.7301 | 0.7287 | 0.0015 | 0.0025 | 0.0041 | 0.0259 | 0.0498 | 0.0747 | 0.0503 | 0.0711 | 0.7202 | |
MCF7 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 615 | 87 | 3644 | 13644 | 486.1 | 117.15 | 117.91 | 188.35 | 319 | 379 | 428 | 463 | 490 | 516 | 545 | 579 | 629 | 0.0704 | 960 | 0.778 | 78.75 | 25.08 | 2 | 0.0645 | 235 | 0.0008 | 59.20 | 7.366 | 0.1629 | 250045.0 | 135000000 | 76400000000 | 45000000000000 | 0.3808 | 0.2634 | 0.0005 | 0.0003 | 0.0023 | 0.0006 | 0.0065 | 0.0012 | 0.0208 | 0.0024 | 0.0644 | 0.0260 | 0.1185 | 0.0474 | 0.1181 | 0.0477 | 0.1537 | 0.0608 | 0.5153 | 0.8136 | 0.0004 | 0.0003 | 0.0004 | 0.0006 | 0.0025 | 0.0009 | 0.0053 | 0.0017 | 0.0246 | 0.0206 | 0.0421 | 0.0342 | 0.0333 | 0.0284 | 0.0512 | 0.0353 | 0.8404 | 0.8781 | 0.0029 | 0.0165 | 0.0072 | 0.0110 | 0.0435 | 0.0165 | 0.0609 | 0.0824 | 0.1493 | 0.1319 | 0.1493 | 0.1648 | 0.1232 | 0.1044 | 0.1130 | 0.1154 | 0.3507 | 0.3571 | 0.0011 | 0.0005 | 0.0037 | 0.0186 | 0.0541 | 0.0981 | 0.1140 | 0.1352 | 0.5748 | 5 | 7 | 9 | 12 | 18 | 41 | 105 | 209 | 414 | 0.0925 | 12.28 | 4.224 | 0.5614 | 49376.8 | 28700000 | 20000000000 | 16200000000000 | 0.4378 | 0.2206 | 0.0432 | 0.0012 | 0.1512 | 0.0148 | 0.2160 | 0.0598 | 0.1677 | 0.1006 | 0.1423 | 0.1764 | 0.1017 | 0.1795 | 0.0839 | 0.1388 | 0.0597 | 0.1184 | 0.0343 | 0.2104 | 0.0002 | 0.0000 | 0.0007 | 0.0011 | 0.0035 | 0.0013 | 0.0091 | 0.0065 | 0.0424 | 0.0378 | 0.0666 | 0.0551 | 0.0544 | 0.0477 | 0.0811 | 0.0656 | 0.7419 | 0.7849 | 0.0006 | 0.0006 | 0.0023 | 0.0029 | 0.0046 | 0.0048 | 0.0126 | 0.0140 | 0.0584 | 0.0619 | 0.0822 | 0.0909 | 0.0664 | 0.0635 | 0.0908 | 0.0804 | 0.6821 | 0.6810 | 0.0000 | 0.0018 | 0.0028 | 0.0106 | 0.0536 | 0.0732 | 0.0590 | 0.0912 | 0.7077 | |
MCF7 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 854 | 405 | 7527 | 31665 | 388.4 | 72.66 | 93.45 | 141.02 | 301 | 326 | 347 | 364 | 382 | 400 | 421 | 447 | 487 | 0.0374 | 1185 | 1.088 | 108.58 | 28.32 | 1 | 0.0323 | 243 | 0.0008 | 48.68 | 7.360 | 0.1631 | 156148.0 | 64900000 | 27900000000 | 12400000000000 | 0.4021 | 0.2480 | 0.0000 | 0.0000 | 0.0006 | 0.0000 | 0.0046 | 0.0001 | 0.0110 | 0.0014 | 0.0414 | 0.0136 | 0.1010 | 0.0353 | 0.0993 | 0.0248 | 0.1508 | 0.0388 | 0.5912 | 0.8859 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0011 | 0.0001 | 0.0052 | 0.0005 | 0.0195 | 0.0099 | 0.0510 | 0.0234 | 0.0462 | 0.0107 | 0.0737 | 0.0159 | 0.8031 | 0.9394 | 0.0056 | 0.0138 | 0.0130 | 0.0826 | 0.0241 | 0.0872 | 0.0519 | 0.1193 | 0.1270 | 0.1560 | 0.1724 | 0.2294 | 0.1233 | 0.0917 | 0.1483 | 0.0734 | 0.3346 | 0.1468 | 0.0008 | 0.0025 | 0.0065 | 0.0239 | 0.0686 | 0.1113 | 0.0975 | 0.1231 | 0.5659 | 6 | 8 | 11 | 21 | 39 | 63 | 99 | 156 | 250 | 0.0635 | 9.53 | 4.513 | 0.5426 | 28619.4 | 17100000 | 15800000000 | 18600000000000 | 0.4450 | 0.1844 | 0.0328 | 0.0005 | 0.1395 | 0.0088 | 0.2204 | 0.0603 | 0.1624 | 0.1175 | 0.1549 | 0.1747 | 0.1262 | 0.2022 | 0.0836 | 0.1486 | 0.0471 | 0.1229 | 0.0331 | 0.1645 | 0.0003 | 0.0001 | 0.0008 | 0.0004 | 0.0022 | 0.0027 | 0.0119 | 0.0124 | 0.0537 | 0.0399 | 0.0815 | 0.0673 | 0.0674 | 0.0542 | 0.0954 | 0.0807 | 0.6869 | 0.7423 | 0.0007 | 0.0007 | 0.0017 | 0.0008 | 0.0046 | 0.0050 | 0.0176 | 0.0205 | 0.0658 | 0.0826 | 0.1195 | 0.1283 | 0.0762 | 0.0818 | 0.1160 | 0.1209 | 0.5979 | 0.5594 | 0.0003 | 0.0015 | 0.0051 | 0.0174 | 0.0607 | 0.0986 | 0.0754 | 0.1077 | 0.6333 | |
Hs 578T | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 171 | 227 | 13156 | 26560 | 216.3 | 55.08 | 143.33 | 196.83 | 147 | 172 | 189 | 203 | 217 | 231 | 246 | 263 | 286 | 0.0570 | 1514 | 0.695 | 170.21 | 47.54 | 3 | 0.0364 | 479 | 0.0008 | 42.66 | 7.414 | 0.1765 | 49810.3 | 12100000 | 3040000000 | 797000000000 | 0.4175 | 0.2260 | 0.0007 | 0.0001 | 0.0014 | 0.0001 | 0.0076 | 0.0009 | 0.0228 | 0.0052 | 0.0655 | 0.0153 | 0.1188 | 0.0349 | 0.1344 | 0.0418 | 0.1753 | 0.0659 | 0.4735 | 0.8359 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0012 | 0.0004 | 0.0075 | 0.0020 | 0.0220 | 0.0098 | 0.0398 | 0.0182 | 0.0480 | 0.0148 | 0.0644 | 0.0241 | 0.8168 | 0.9308 | 0.0028 | 0.0282 | 0.0118 | 0.0267 | 0.0277 | 0.0847 | 0.0602 | 0.1278 | 0.0906 | 0.1798 | 0.1387 | 0.1575 | 0.1280 | 0.1189 | 0.1505 | 0.1218 | 0.3898 | 0.1545 | 0.0012 | 0.0034 | 0.0079 | 0.0230 | 0.0477 | 0.0880 | 0.0938 | 0.1052 | 0.6296 | 16 | 19 | 22 | 26 | 40 | 80 | 154 | 256 | 424 | 0.0499 | 24.57 | 5.020 | 0.5076 | 59283.3 | 35800000 | 26400000000 | 22500000000000 | 0.6077 | 0.0916 | 0.0465 | 0.0024 | 0.1573 | 0.0221 | 0.2370 | 0.0945 | 0.1899 | 0.1299 | 0.1567 | 0.1853 | 0.1107 | 0.1877 | 0.0559 | 0.1296 | 0.0288 | 0.1216 | 0.0172 | 0.1270 | 0.0004 | 0.0003 | 0.0007 | 0.0014 | 0.0025 | 0.0019 | 0.0149 | 0.0139 | 0.0556 | 0.0499 | 0.0753 | 0.0693 | 0.0592 | 0.0511 | 0.0899 | 0.0801 | 0.7015 | 0.7321 | 0.0005 | 0.0015 | 0.0016 | 0.0014 | 0.0046 | 0.0059 | 0.0219 | 0.0234 | 0.0658 | 0.0751 | 0.1028 | 0.1190 | 0.0811 | 0.0870 | 0.1118 | 0.1202 | 0.6099 | 0.5665 | 0.0007 | 0.0013 | 0.0027 | 0.0190 | 0.0556 | 0.0905 | 0.0669 | 0.0992 | 0.6642 | |
MCF7 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 318 | 872 | 12186 | 25790 | 350.1 | 84.35 | 180.74 | 231.33 | 250 | 278 | 300 | 319 | 340 | 362 | 386 | 419 | 463 | 0.0459 | 1185 | 1.241 | 90.52 | 37.58 | 1 | 0.0197 | 240 | 0.0006 | 79.84 | 7.705 | 0.1428 | 129698.0 | 50800000 | 21000000000 | 9160000000000 | 0.4637 | 0.1985 | 0.0008 | 0.0000 | 0.0050 | 0.0002 | 0.0093 | 0.0019 | 0.0269 | 0.0039 | 0.0810 | 0.0184 | 0.1487 | 0.0417 | 0.1625 | 0.0489 | 0.1712 | 0.0732 | 0.3947 | 0.8118 | 0.0001 | 0.0000 | 0.0006 | 0.0000 | 0.0020 | 0.0001 | 0.0091 | 0.0003 | 0.0330 | 0.0101 | 0.0662 | 0.0219 | 0.0745 | 0.0199 | 0.0941 | 0.0344 | 0.7203 | 0.9133 | 0.0050 | 0.0088 | 0.0083 | 0.0113 | 0.0190 | 0.0479 | 0.0690 | 0.1614 | 0.1467 | 0.1589 | 0.1789 | 0.2320 | 0.1149 | 0.1236 | 0.1471 | 0.1097 | 0.3112 | 0.1463 | 0.0009 | 0.0031 | 0.0086 | 0.0355 | 0.0810 | 0.1311 | 0.1118 | 0.1336 | 0.4943 | 10 | 15 | 25 | 45 | 80 | 130 | 204 | 324 | 514 | 0.0440 | 29.42 | 5.543 | 0.4890 | 86176.2 | 59000000 | 49700000000 | 48200000000000 | 0.4861 | 0.1546 | 0.0520 | 0.0023 | 0.1701 | 0.0129 | 0.2665 | 0.0966 | 0.1459 | 0.1378 | 0.1201 | 0.1935 | 0.1172 | 0.1886 | 0.0605 | 0.1155 | 0.0372 | 0.1007 | 0.0305 | 0.1521 | 0.0003 | 0.0004 | 0.0012 | 0.0006 | 0.0023 | 0.0023 | 0.0133 | 0.0093 | 0.0591 | 0.0486 | 0.0997 | 0.0816 | 0.0694 | 0.0558 | 0.1037 | 0.0915 | 0.6512 | 0.7099 | 0.0005 | 0.0003 | 0.0007 | 0.0026 | 0.0046 | 0.0032 | 0.0156 | 0.0218 | 0.0784 | 0.0855 | 0.1293 | 0.1333 | 0.0752 | 0.0852 | 0.1163 | 0.1277 | 0.5793 | 0.5404 | 0.0006 | 0.0014 | 0.0033 | 0.0161 | 0.0656 | 0.1205 | 0.0715 | 0.1126 | 0.6084 | |
MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 260 | 906 | 6741 | 5810 | 457.5 | 85.03 | 189.24 | 346.87 | 354 | 397 | 434 | 457 | 471 | 484 | 497 | 515 | 542 | 0.1139 | 662 | 0.726 | 107.34 | 27.78 | 4 | 0.0481 | 324 | 0.0013 | 28.66 | 7.062 | 0.2336 | 216541.0 | 105000000 | 52100000000 | 26300000000000 | 0.4404 | 0.2127 | 0.0000 | 0.0000 | 0.0013 | 0.0000 | 0.0038 | 0.0000 | 0.0072 | 0.0011 | 0.0244 | 0.0142 | 0.0415 | 0.0371 | 0.0385 | 0.0169 | 0.0651 | 0.0290 | 0.8182 | 0.9017 | 0.0000 | 0.0000 | 0.0009 | 0.0000 | 0.0026 | 0.0000 | 0.0044 | 0.0005 | 0.0175 | 0.0138 | 0.0303 | 0.0338 | 0.0218 | 0.0135 | 0.0322 | 0.0208 | 0.8903 | 0.9176 | 0.0174 | 0.0000 | 0.0209 | 0.0000 | 0.0192 | 0.0000 | 0.0314 | 0.0000 | 0.0401 | 0.0000 | 0.0627 | 0.0000 | 0.0592 | 0.0000 | 0.0941 | 0.0000 | 0.6551 | 0.0000 | 0.0007 | 0.0045 | 0.0057 | 0.0172 | 0.0314 | 0.0528 | 0.0617 | 0.0889 | 0.7372 | 15 | 17 | 18 | 21 | 27 | 55 | 114 | 280 | 602 | 0.2435 | 18.42 | 3.549 | 0.6966 | 156109.0 | 197000000 | 310000000000 | 567000000000000 | 0.6374 | 0.0658 | 0.0763 | 0.0000 | 0.1968 | 0.0329 | 0.2129 | 0.1024 | 0.1566 | 0.1225 | 0.1406 | 0.1846 | 0.1245 | 0.1554 | 0.0482 | 0.1280 | 0.0361 | 0.1188 | 0.0080 | 0.1554 | 0.0013 | 0.0000 | 0.0019 | 0.0006 | 0.0039 | 0.0023 | 0.0142 | 0.0138 | 0.0685 | 0.0619 | 0.0931 | 0.0865 | 0.0672 | 0.0613 | 0.1002 | 0.0980 | 0.6496 | 0.6756 | 0.0008 | 0.0000 | 0.0031 | 0.0025 | 0.0046 | 0.0067 | 0.0208 | 0.0200 | 0.0701 | 0.0835 | 0.1017 | 0.0943 | 0.0770 | 0.0760 | 0.1063 | 0.1077 | 0.6156 | 0.6093 | 0.0000 | 0.0014 | 0.0043 | 0.0157 | 0.0686 | 0.1029 | 0.0657 | 0.1064 | 0.6350 | |
BT-20 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 150 | 710 | 6177 | 14509 | 257.7 | 49.98 | 159.94 | 175.38 | 195 | 216 | 230 | 243 | 255 | 267 | 280 | 296 | 323 | 0.0733 | 1064 | 0.993 | 123.79 | 34.53 | 1 | 0.0478 | 295 | 0.0009 | 53.18 | 7.248 | 0.1699 | 68920.1 | 19100000 | 5500000000 | 1640000000000 | 0.4318 | 0.2171 | 0.0000 | 0.0000 | 0.0009 | 0.0002 | 0.0030 | 0.0002 | 0.0173 | 0.0017 | 0.0536 | 0.0129 | 0.0983 | 0.0305 | 0.1154 | 0.0290 | 0.1599 | 0.0498 | 0.5517 | 0.8757 | 0.0000 | 0.0000 | 0.0004 | 0.0002 | 0.0013 | 0.0000 | 0.0044 | 0.0013 | 0.0238 | 0.0098 | 0.0441 | 0.0207 | 0.0492 | 0.0117 | 0.0819 | 0.0218 | 0.7949 | 0.9346 | 0.0103 | 0.0328 | 0.0091 | 0.0437 | 0.0343 | 0.1202 | 0.0926 | 0.1421 | 0.1669 | 0.1585 | 0.1829 | 0.1530 | 0.1291 | 0.0710 | 0.1451 | 0.1202 | 0.2297 | 0.1585 | 0.0007 | 0.0031 | 0.0099 | 0.0358 | 0.0782 | 0.1328 | 0.1171 | 0.1540 | 0.4684 | 16 | 20 | 33 | 57 | 93 | 139 | 201 | 286 | 409 | 0.0208 | 27.02 | 5.804 | 0.4346 | 56339.0 | 28300000 | 18000000000 | 13700000000000 | 0.5203 | 0.1387 | 0.0476 | 0.0018 | 0.1694 | 0.0111 | 0.2272 | 0.1026 | 0.1326 | 0.1244 | 0.1282 | 0.1647 | 0.1104 | 0.1591 | 0.0736 | 0.1121 | 0.0615 | 0.1069 | 0.0495 | 0.2172 | 0.0002 | 0.0000 | 0.0018 | 0.0007 | 0.0049 | 0.0018 | 0.0131 | 0.0102 | 0.0685 | 0.0529 | 0.1030 | 0.0883 | 0.0768 | 0.0614 | 0.1123 | 0.0986 | 0.6194 | 0.6860 | 0.0007 | 0.0003 | 0.0022 | 0.0038 | 0.0046 | 0.0082 | 0.0208 | 0.0260 | 0.0828 | 0.0984 | 0.1265 | 0.1386 | 0.0956 | 0.0989 | 0.1283 | 0.1435 | 0.5386 | 0.4824 | 0.0004 | 0.0027 | 0.0042 | 0.0175 | 0.0747 | 0.1189 | 0.0808 | 0.1256 | 0.5753 | |
MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 536 | 592 | 11784 | 41678 | 115.6 | 34.59 | 207.83 | 214.61 | 75 | 86 | 94 | 103 | 111 | 120 | 130 | 144 | 163 | 0.0416 | 1732 | 0.727 | 154.55 | 39.40 | 3 | 0.0386 | 455 | 0.0021 | 19.63 | 6.518 | 0.2766 | 14550.8 | 1990000 | 293000000 | 46400000000 | 0.4899 | 0.1699 | 0.0021 | 0.0004 | 0.0048 | 0.0007 | 0.0141 | 0.0032 | 0.0416 | 0.0077 | 0.1062 | 0.0329 | 0.1621 | 0.0738 | 0.1591 | 0.0708 | 0.1647 | 0.0991 | 0.3453 | 0.7113 | 0.0007 | 0.0001 | 0.0018 | 0.0005 | 0.0040 | 0.0013 | 0.0122 | 0.0039 | 0.0406 | 0.0176 | 0.0687 | 0.0392 | 0.0628 | 0.0280 | 0.0796 | 0.0464 | 0.7295 | 0.8631 | 0.0022 | 0.0025 | 0.0041 | 0.0115 | 0.0137 | 0.0329 | 0.0504 | 0.0873 | 0.1067 | 0.1853 | 0.1530 | 0.1919 | 0.1278 | 0.1227 | 0.1467 | 0.1524 | 0.3956 | 0.2133 | 0.0013 | 0.0036 | 0.0085 | 0.0266 | 0.0690 | 0.1142 | 0.0929 | 0.1140 | 0.5699 | 15 | 20 | 37 | 80 | 139 | 203 | 278 | 375 | 515 | 0.0215 | 74.38 | 6.685 | 0.3397 | 89248.9 | 51000000 | 34800000000 | 27200000000000 | 0.4252 | 0.2362 | 0.0235 | 0.0012 | 0.1173 | 0.0073 | 0.2179 | 0.0568 | 0.1485 | 0.1081 | 0.1623 | 0.1648 | 0.1467 | 0.2023 | 0.0826 | 0.1340 | 0.0615 | 0.1331 | 0.0396 | 0.1923 | 0.0003 | 0.0001 | 0.0006 | 0.0004 | 0.0028 | 0.0018 | 0.0089 | 0.0066 | 0.0493 | 0.0407 | 0.0985 | 0.0784 | 0.0722 | 0.0592 | 0.0927 | 0.0831 | 0.6748 | 0.7298 | 0.0013 | 0.0008 | 0.0022 | 0.0025 | 0.0046 | 0.0081 | 0.0169 | 0.0211 | 0.0664 | 0.0802 | 0.1232 | 0.1307 | 0.0875 | 0.0958 | 0.1112 | 0.1158 | 0.5867 | 0.5449 | 0.0005 | 0.0023 | 0.0051 | 0.0144 | 0.0596 | 0.1114 | 0.0778 | 0.1061 | 0.6229 | |
BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1118 | 571 | 8114 | 11473 | 287.2 | 51.13 | 167.28 | 160.52 | 216 | 244 | 261 | 276 | 288 | 301 | 314 | 330 | 353 | 0.0825 | 946 | 0.972 | 44.55 | 15.65 | 1 | 0.0148 | 120 | 0.0020 | 14.93 | 6.529 | 0.2976 | 85117.2 | 26000000 | 8120000000 | 2600000000000 | 0.4373 | 0.2063 | 0.0005 | 0.0000 | 0.0015 | 0.0001 | 0.0027 | 0.0005 | 0.0121 | 0.0011 | 0.0320 | 0.0115 | 0.0585 | 0.0247 | 0.0605 | 0.0158 | 0.0827 | 0.0277 | 0.7495 | 0.9185 | 0.0003 | 0.0000 | 0.0003 | 0.0001 | 0.0010 | 0.0005 | 0.0049 | 0.0009 | 0.0130 | 0.0100 | 0.0228 | 0.0207 | 0.0186 | 0.0103 | 0.0277 | 0.0182 | 0.9114 | 0.9393 | 0.0075 | 0.0000 | 0.0197 | 0.0000 | 0.0254 | 0.0000 | 0.0630 | 0.0000 | 0.1006 | 0.0000 | 0.1410 | 0.0000 | 0.1194 | 0.0000 | 0.1391 | 0.0000 | 0.3844 | 0.0000 | 0.0017 | 0.0038 | 0.0094 | 0.0183 | 0.0428 | 0.0657 | 0.0729 | 0.0940 | 0.6914 | 14 | 20 | 33 | 56 | 109 | 178 | 247 | 321 | 407 | 0.0262 | 16.95 | 5.600 | 0.4608 | 53749.5 | 21300000 | 9500000000 | 4610000000000 | 0.5388 | 0.1195 | 0.0204 | 0.0036 | 0.0844 | 0.0071 | 0.2027 | 0.0554 | 0.2124 | 0.0996 | 0.1858 | 0.1765 | 0.1449 | 0.1957 | 0.0853 | 0.1425 | 0.0427 | 0.1367 | 0.0213 | 0.1828 | 0.0002 | 0.0002 | 0.0004 | 0.0000 | 0.0021 | 0.0010 | 0.0084 | 0.0088 | 0.0392 | 0.0312 | 0.0742 | 0.0636 | 0.0517 | 0.0429 | 0.0751 | 0.0700 | 0.7487 | 0.7823 | 0.0007 | 0.0000 | 0.0005 | 0.0016 | 0.0047 | 0.0066 | 0.0145 | 0.0172 | 0.0499 | 0.0620 | 0.0929 | 0.1039 | 0.0689 | 0.0823 | 0.0990 | 0.1175 | 0.6690 | 0.6089 | 0.0010 | 0.0008 | 0.0017 | 0.0109 | 0.0468 | 0.0801 | 0.0606 | 0.0887 | 0.7093 | |
Hs 578T | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1262 | 191 | 1146 | 5093 | 90.2 | 37.96 | 173.01 | 291.74 | 37 | 56 | 70 | 80 | 89 | 98 | 108 | 122 | 139 | 0.1056 | 538 | 0.246 | 326.81 | 58.25 | 3 | 1.2321 | 1412 | 0.0022 | 29.57 | 6.284 | 0.2125 | 9584.0 | 1150000 | 154000000 | 22500000000 | 0.3879 | 0.2271 | 0.0045 | 0.0000 | 0.0182 | 0.0000 | 0.0795 | 0.0040 | 0.0932 | 0.0173 | 0.1295 | 0.0840 | 0.1705 | 0.1280 | 0.1705 | 0.1333 | 0.1955 | 0.1453 | 0.1386 | 0.4880 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0025 | 0.0000 | 0.0064 | 0.0032 | 0.0446 | 0.0319 | 0.0841 | 0.0554 | 0.0828 | 0.0405 | 0.1338 | 0.0692 | 0.6459 | 0.7998 | 0.0000 | 0.0106 | 0.0087 | 0.0212 | 0.0203 | 0.0159 | 0.0580 | 0.0847 | 0.1130 | 0.2328 | 0.1652 | 0.2011 | 0.1275 | 0.1164 | 0.1739 | 0.1270 | 0.3333 | 0.1905 | 0.0035 | 0.0018 | 0.0089 | 0.0319 | 0.0904 | 0.1294 | 0.1188 | 0.1489 | 0.4663 | 14 | 16 | 18 | 21 | 25 | 39 | 104 | 323 | 583 | 0.0764 | 34.57 | 4.571 | 0.5346 | 115023.0 | 109000000 | 127000000000 | 170000000000000 | 0.7263 | 0.0444 | 0.0738 | 0.0122 | 0.3020 | 0.0550 | 0.3087 | 0.1498 | 0.1477 | 0.2385 | 0.1208 | 0.2599 | 0.0201 | 0.1346 | 0.0134 | 0.0642 | 0.0134 | 0.0367 | 0.0000 | 0.0489 | 0.0000 | 0.0007 | 0.0028 | 0.0013 | 0.0028 | 0.0033 | 0.0264 | 0.0209 | 0.0674 | 0.0712 | 0.1035 | 0.0935 | 0.0757 | 0.0745 | 0.1070 | 0.1085 | 0.6143 | 0.6261 | 0.0016 | 0.0000 | 0.0023 | 0.0025 | 0.0047 | 0.0183 | 0.0287 | 0.0241 | 0.0636 | 0.0665 | 0.1116 | 0.1155 | 0.0853 | 0.0840 | 0.1124 | 0.1139 | 0.5899 | 0.5752 | 0.0007 | 0.0029 | 0.0066 | 0.0269 | 0.0655 | 0.1077 | 0.0852 | 0.1033 | 0.6012 | |
MCF7 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 590 | 585 | 6499 | 12657 | 474.1 | 105.05 | 39.01 | 84.66 | 344 | 379 | 410 | 438 | 465 | 494 | 525 | 566 | 619 | 0.0658 | 833 | 0.436 | 85.09 | 24.33 | 2 | 0.0495 | 322 | 0.0005 | 98.02 | 7.849 | 0.1181 | 235821.0 | 123000000 | 66600000000 | 37500000000000 | 0.4186 | 0.2373 | 0.0003 | 0.0000 | 0.0010 | 0.0000 | 0.0081 | 0.0002 | 0.0234 | 0.0021 | 0.0846 | 0.0185 | 0.1319 | 0.0439 | 0.1403 | 0.0446 | 0.1617 | 0.0662 | 0.4487 | 0.8246 | 0.0002 | 0.0000 | 0.0000 | 0.0000 | 0.0017 | 0.0000 | 0.0075 | 0.0012 | 0.0359 | 0.0131 | 0.0667 | 0.0284 | 0.0658 | 0.0201 | 0.0850 | 0.0339 | 0.7372 | 0.9033 | 0.0024 | 0.0066 | 0.0072 | 0.0197 | 0.0168 | 0.0623 | 0.0455 | 0.1049 | 0.1310 | 0.2164 | 0.1566 | 0.1934 | 0.1054 | 0.1213 | 0.1454 | 0.1016 | 0.3898 | 0.1738 | 0.0007 | 0.0013 | 0.0093 | 0.0251 | 0.0753 | 0.1245 | 0.0951 | 0.1176 | 0.5510 | 8 | 10 | 11 | 13 | 14 | 16 | 20 | 32 | 83 | 0.3458 | 2.93 | 2.365 | 0.7930 | 8689.1 | 4200000 | 2620000000 | 1850000000000 | 0.5811 | 0.1080 | 0.0885 | 0.0104 | 0.2543 | 0.0345 | 0.2812 | 0.1127 | 0.1438 | 0.1577 | 0.1011 | 0.2117 | 0.0616 | 0.1837 | 0.0442 | 0.1186 | 0.0221 | 0.0840 | 0.0032 | 0.0866 | 0.0012 | 0.0043 | 0.0039 | 0.0074 | 0.0075 | 0.0086 | 0.0365 | 0.0296 | 0.0821 | 0.0734 | 0.1147 | 0.0932 | 0.0825 | 0.0839 | 0.1222 | 0.1175 | 0.5495 | 0.5820 | 0.0016 | 0.0023 | 0.0031 | 0.0012 | 0.0047 | 0.0059 | 0.0350 | 0.0457 | 0.0957 | 0.1019 | 0.1479 | 0.1547 | 0.0883 | 0.0873 | 0.1181 | 0.1131 | 0.5055 | 0.4880 | 0.0009 | 0.0059 | 0.0054 | 0.0345 | 0.0917 | 0.1226 | 0.0903 | 0.1207 | 0.5279 | |
BT-20 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1039 | 222 | 8267 | 22106 | 288.0 | 59.05 | 151.11 | 185.59 | 216 | 238 | 254 | 269 | 282 | 298 | 314 | 336 | 366 | 0.0470 | 1038 | 1.207 | 123.17 | 44.29 | 1 | 0.0368 | 304 | 0.0006 | 72.43 | 7.591 | 0.1414 | 86440.9 | 27000000 | 8770000000 | 2960000000000 | 0.4619 | 0.1920 | 0.0002 | 0.0000 | 0.0011 | 0.0000 | 0.0049 | 0.0001 | 0.0163 | 0.0014 | 0.0611 | 0.0158 | 0.1248 | 0.0327 | 0.1394 | 0.0332 | 0.1689 | 0.0503 | 0.4834 | 0.8666 | 0.0001 | 0.0000 | 0.0001 | 0.0000 | 0.0004 | 0.0000 | 0.0049 | 0.0000 | 0.0290 | 0.0113 | 0.0560 | 0.0195 | 0.0638 | 0.0161 | 0.0864 | 0.0281 | 0.7592 | 0.9250 | 0.0044 | 0.0122 | 0.0059 | 0.0122 | 0.0344 | 0.0459 | 0.0659 | 0.0979 | 0.1553 | 0.2049 | 0.1919 | 0.2141 | 0.1114 | 0.1070 | 0.1495 | 0.1346 | 0.2813 | 0.1713 | 0.0026 | 0.0018 | 0.0099 | 0.0342 | 0.0861 | 0.1315 | 0.1084 | 0.1380 | 0.4874 | 12 | 15 | 17 | 24 | 55 | 118 | 196 | 294 | 424 | 0.0394 | 36.87 | 5.514 | 0.4378 | 57275.2 | 29300000 | 17900000000 | 12400000000000 | 0.4786 | 0.1762 | 0.0641 | 0.0023 | 0.1929 | 0.0255 | 0.2734 | 0.1224 | 0.1781 | 0.1756 | 0.1168 | 0.1948 | 0.0851 | 0.1693 | 0.0556 | 0.1219 | 0.0221 | 0.0910 | 0.0119 | 0.0973 | 0.0001 | 0.0000 | 0.0005 | 0.0005 | 0.0019 | 0.0008 | 0.0100 | 0.0091 | 0.0516 | 0.0439 | 0.0899 | 0.0793 | 0.0692 | 0.0605 | 0.0927 | 0.0806 | 0.6841 | 0.7253 | 0.0014 | 0.0005 | 0.0020 | 0.0011 | 0.0047 | 0.0047 | 0.0137 | 0.0179 | 0.0676 | 0.0722 | 0.1069 | 0.1192 | 0.0847 | 0.0896 | 0.1139 | 0.1168 | 0.6051 | 0.5781 | 0.0001 | 0.0011 | 0.0038 | 0.0118 | 0.0592 | 0.1021 | 0.0731 | 0.1069 | 0.6419 | |
MCF7 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 198 | 613 | 10703 | 25098 | 480.9 | 117.51 | 176.04 | 229.83 | 340 | 382 | 416 | 442 | 466 | 492 | 523 | 565 | 635 | 0.0451 | 1133 | 1.039 | 108.30 | 27.31 | 1 | 0.0238 | 255 | 0.0012 | 25.67 | 7.037 | 0.2548 | 245102.0 | 133000000 | 76300000000 | 46700000000000 | 0.4289 | 0.2132 | 0.0002 | 0.0001 | 0.0017 | 0.0003 | 0.0032 | 0.0004 | 0.0125 | 0.0023 | 0.0362 | 0.0148 | 0.0705 | 0.0249 | 0.0739 | 0.0234 | 0.1025 | 0.0348 | 0.6994 | 0.8989 | 0.0001 | 0.0000 | 0.0011 | 0.0000 | 0.0013 | 0.0000 | 0.0040 | 0.0009 | 0.0147 | 0.0099 | 0.0296 | 0.0144 | 0.0296 | 0.0114 | 0.0431 | 0.0165 | 0.8765 | 0.9467 | 0.0027 | 0.0042 | 0.0037 | 0.0125 | 0.0197 | 0.0111 | 0.0256 | 0.0376 | 0.0809 | 0.0794 | 0.0969 | 0.1059 | 0.0793 | 0.0975 | 0.1145 | 0.1170 | 0.5767 | 0.5348 | 0.0011 | 0.0046 | 0.0057 | 0.0221 | 0.0472 | 0.0715 | 0.0723 | 0.0974 | 0.6780 | 8 | 11 | 18 | 43 | 88 | 143 | 209 | 306 | 470 | 0.0340 | 59.76 | 6.000 | 0.4097 | 83807.8 | 61300000 | 58300000000 | 65200000000000 | 0.4708 | 0.1676 | 0.0402 | 0.0013 | 0.1379 | 0.0145 | 0.2575 | 0.0830 | 0.1639 | 0.1217 | 0.1467 | 0.1865 | 0.1105 | 0.1891 | 0.0710 | 0.1300 | 0.0457 | 0.1206 | 0.0267 | 0.1533 | 0.0004 | 0.0001 | 0.0006 | 0.0003 | 0.0013 | 0.0011 | 0.0127 | 0.0082 | 0.0586 | 0.0466 | 0.0992 | 0.0851 | 0.0724 | 0.0582 | 0.1097 | 0.0882 | 0.6453 | 0.7122 | 0.0004 | 0.0016 | 0.0013 | 0.0016 | 0.0047 | 0.0061 | 0.0204 | 0.0261 | 0.0847 | 0.0889 | 0.1296 | 0.1451 | 0.0831 | 0.0884 | 0.1286 | 0.1255 | 0.5472 | 0.5169 | 0.0007 | 0.0010 | 0.0037 | 0.0134 | 0.0728 | 0.1205 | 0.0761 | 0.1192 | 0.5926 | |||
MCF7 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1208 | 205 | 6928 | 22071 | 341.7 | 78.65 | 108.42 | 121.55 | 242 | 273 | 297 | 318 | 338 | 358 | 381 | 406 | 444 | 0.0464 | 1025 | 0.821 | 127.02 | 32.56 | 1 | 0.0485 | 336 | 0.0010 | 44.29 | 7.174 | 0.1864 | 122938.0 | 46400000 | 18300000000 | 7530000000000 | 0.4442 | 0.2150 | 0.0005 | 0.0000 | 0.0009 | 0.0002 | 0.0054 | 0.0000 | 0.0289 | 0.0006 | 0.0774 | 0.0196 | 0.1548 | 0.0468 | 0.1496 | 0.0486 | 0.1733 | 0.0699 | 0.4092 | 0.8144 | 0.0002 | 0.0000 | 0.0004 | 0.0001 | 0.0007 | 0.0000 | 0.0054 | 0.0001 | 0.0331 | 0.0134 | 0.0668 | 0.0319 | 0.0580 | 0.0246 | 0.0875 | 0.0358 | 0.7479 | 0.8940 | 0.0023 | 0.0124 | 0.0062 | 0.0155 | 0.0247 | 0.0310 | 0.0918 | 0.1455 | 0.1550 | 0.2012 | 0.1958 | 0.1827 | 0.1210 | 0.1022 | 0.1365 | 0.1269 | 0.2668 | 0.1827 | 0.0003 | 0.0015 | 0.0063 | 0.0271 | 0.0855 | 0.1353 | 0.1139 | 0.1317 | 0.4984 | 9 | 13 | 22 | 40 | 63 | 94 | 133 | 188 | 275 | 0.0306 | 13.52 | 5.344 | 0.4677 | 26526.8 | 9310000 | 4040000000 | 2020000000000 | 0.4133 | 0.2398 | 0.0339 | 0.0012 | 0.1396 | 0.0060 | 0.2401 | 0.0523 | 0.1953 | 0.1264 | 0.1400 | 0.1867 | 0.1291 | 0.2003 | 0.0747 | 0.1544 | 0.0331 | 0.1250 | 0.0141 | 0.1478 | 0.0006 | 0.0003 | 0.0014 | 0.0015 | 0.0028 | 0.0033 | 0.0161 | 0.0120 | 0.0537 | 0.0500 | 0.0941 | 0.0727 | 0.0729 | 0.0606 | 0.1043 | 0.0889 | 0.6540 | 0.7107 | 0.0007 | 0.0010 | 0.0031 | 0.0019 | 0.0047 | 0.0087 | 0.0232 | 0.0267 | 0.0849 | 0.0952 | 0.1181 | 0.1316 | 0.0860 | 0.0864 | 0.1223 | 0.1332 | 0.5570 | 0.5153 | 0.0002 | 0.0019 | 0.0039 | 0.0193 | 0.0666 | 0.1098 | 0.0796 | 0.1117 | 0.6070 | |
BT-20 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 948 | 602 | 5482 | 6626 | 431.8 | 96.54 | 133.95 | 147.02 | 321 | 351 | 372 | 394 | 415 | 441 | 472 | 515 | 567 | 0.1180 | 782 | 1.222 | 113.85 | 42.45 | 1 | 0.0520 | 285 | 0.0009 | 43.04 | 7.265 | 0.1744 | 195782.0 | 93200000 | 46500000000 | 24300000000000 | 0.4072 | 0.2460 | 0.0012 | 0.0000 | 0.0006 | 0.0000 | 0.0035 | 0.0000 | 0.0145 | 0.0012 | 0.0707 | 0.0208 | 0.1385 | 0.0387 | 0.1405 | 0.0363 | 0.1657 | 0.0562 | 0.4649 | 0.8469 | 0.0007 | 0.0000 | 0.0000 | 0.0000 | 0.0018 | 0.0000 | 0.0056 | 0.0004 | 0.0357 | 0.0158 | 0.0655 | 0.0214 | 0.0748 | 0.0204 | 0.0919 | 0.0339 | 0.7240 | 0.9081 | 0.0029 | 0.0035 | 0.0029 | 0.0035 | 0.0095 | 0.0141 | 0.0475 | 0.0742 | 0.0846 | 0.1696 | 0.1454 | 0.2155 | 0.1055 | 0.1060 | 0.1084 | 0.1095 | 0.4933 | 0.3039 | 0.0021 | 0.0008 | 0.0119 | 0.0296 | 0.0716 | 0.1067 | 0.0809 | 0.0949 | 0.6014 | 11 | 15 | 23 | 44 | 79 | 120 | 169 | 238 | 356 | 0.0197 | 24.70 | 5.729 | 0.4245 | 39552.5 | 16000000 | 7850000000 | 4460000000000 | 0.4462 | 0.1848 | 0.0329 | 0.0007 | 0.1368 | 0.0059 | 0.2053 | 0.0553 | 0.2026 | 0.1211 | 0.1539 | 0.1895 | 0.1250 | 0.1914 | 0.0645 | 0.1303 | 0.0500 | 0.1375 | 0.0289 | 0.1684 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0003 | 0.0012 | 0.0119 | 0.0055 | 0.0633 | 0.0525 | 0.0857 | 0.0756 | 0.0689 | 0.0619 | 0.1147 | 0.1026 | 0.6548 | 0.7008 | 0.0010 | 0.0017 | 0.0010 | 0.0017 | 0.0048 | 0.0039 | 0.0162 | 0.0231 | 0.0796 | 0.0732 | 0.0977 | 0.1082 | 0.0881 | 0.0890 | 0.1148 | 0.1104 | 0.5970 | 0.5887 | 0.0004 | 0.0000 | 0.0029 | 0.0139 | 0.0644 | 0.1076 | 0.0770 | 0.1129 | 0.6209 | |||
MDA-MB-231 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 587 | 223 | 7211 | 12710 | 578.3 | 90.41 | 89.40 | 111.01 | 452 | 510 | 547 | 574 | 591 | 608 | 625 | 646 | 680 | 0.0629 | 799 | 0.795 | 89.56 | 23.85 | 3 | 0.0344 | 248 | 0.0009 | 62.64 | 7.370 | 0.1958 | 342572.0 | 207000000 | 127000000000 | 79600000000000 | 0.4491 | 0.1905 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0012 | 0.0000 | 0.0041 | 0.0004 | 0.0233 | 0.0117 | 0.0460 | 0.0246 | 0.0364 | 0.0110 | 0.0566 | 0.0202 | 0.8320 | 0.9321 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0005 | 0.0000 | 0.0017 | 0.0004 | 0.0145 | 0.0117 | 0.0316 | 0.0246 | 0.0189 | 0.0110 | 0.0268 | 0.0179 | 0.9057 | 0.9343 | 0.0091 | 1.0000 | 0.0146 | 0.0000 | 0.0183 | 0.0000 | 0.0530 | 0.0000 | 0.0804 | 0.0000 | 0.1005 | 0.0000 | 0.1024 | 0.0000 | 0.0951 | 0.0000 | 0.5265 | 0.0000 | 0.0002 | 0.0019 | 0.0045 | 0.0124 | 0.0426 | 0.0660 | 0.0670 | 0.0881 | 0.7172 | 10 | 14 | 19 | 27 | 40 | 63 | 103 | 156 | 234 | 0.0268 | 20.05 | 5.200 | 0.4970 | 20313.0 | 7180000 | 3310000000 | 1810000000000 | 0.4322 | 0.2068 | 0.0263 | 0.0009 | 0.1259 | 0.0110 | 0.2488 | 0.0568 | 0.1902 | 0.1088 | 0.1746 | 0.1845 | 0.1190 | 0.2039 | 0.0576 | 0.1352 | 0.0371 | 0.1325 | 0.0205 | 0.1664 | 0.0006 | 0.0000 | 0.0021 | 0.0011 | 0.0049 | 0.0034 | 0.0148 | 0.0150 | 0.0490 | 0.0449 | 0.0884 | 0.0752 | 0.0504 | 0.0554 | 0.0762 | 0.0747 | 0.7136 | 0.7303 | 0.0008 | 0.0006 | 0.0022 | 0.0034 | 0.0048 | 0.0079 | 0.0202 | 0.0248 | 0.0619 | 0.0657 | 0.0967 | 0.1116 | 0.0695 | 0.0730 | 0.0948 | 0.0920 | 0.6491 | 0.6210 | 0.0000 | 0.0017 | 0.0031 | 0.0174 | 0.0513 | 0.0911 | 0.0613 | 0.0830 | 0.6913 | |
BT-20 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 1189 | 718 | 4088 | 19318 | 453.0 | 106.58 | 96.23 | 99.59 | 325 | 357 | 386 | 412 | 441 | 469 | 504 | 546 | 607 | 0.0500 | 965 | 1.115 | 111.23 | 32.65 | 1 | 0.0624 | 255 | 0.0007 | 67.51 | 7.409 | 0.1424 | 216555.0 | 109000000 | 57400000000 | 31500000000000 | 0.4176 | 0.2368 | 0.0004 | 0.0000 | 0.0008 | 0.0000 | 0.0042 | 0.0003 | 0.0275 | 0.0040 | 0.0803 | 0.0242 | 0.1695 | 0.0594 | 0.1357 | 0.0548 | 0.1682 | 0.0698 | 0.4134 | 0.7875 | 0.0003 | 0.0000 | 0.0000 | 0.0000 | 0.0022 | 0.0000 | 0.0100 | 0.0017 | 0.0344 | 0.0160 | 0.0821 | 0.0397 | 0.0581 | 0.0242 | 0.0865 | 0.0410 | 0.7264 | 0.8774 | 0.0012 | 0.0071 | 0.0084 | 0.0000 | 0.0096 | 0.0249 | 0.0646 | 0.1068 | 0.0969 | 0.1459 | 0.1352 | 0.1851 | 0.1172 | 0.1281 | 0.1148 | 0.1637 | 0.4522 | 0.2384 | 0.0016 | 0.0043 | 0.0070 | 0.0290 | 0.0774 | 0.1198 | 0.0956 | 0.1263 | 0.5390 | 8 | 11 | 16 | 33 | 63 | 99 | 134 | 174 | 230 | 0.0320 | 16.16 | 5.428 | 0.4394 | 19177.9 | 5220000 | 1780000000 | 719000000000 | 0.4849 | 0.1488 | 0.0329 | 0.0012 | 0.1667 | 0.0102 | 0.2528 | 0.0730 | 0.1924 | 0.1400 | 0.1450 | 0.1900 | 0.1015 | 0.2083 | 0.0551 | 0.1299 | 0.0343 | 0.1220 | 0.0193 | 0.1254 | 0.0000 | 0.0000 | 0.0008 | 0.0002 | 0.0020 | 0.0012 | 0.0104 | 0.0077 | 0.0520 | 0.0427 | 0.0878 | 0.0780 | 0.0668 | 0.0541 | 0.0945 | 0.0813 | 0.6857 | 0.7349 | 0.0007 | 0.0007 | 0.0022 | 0.0028 | 0.0048 | 0.0102 | 0.0188 | 0.0254 | 0.0667 | 0.0816 | 0.1172 | 0.1331 | 0.0893 | 0.0932 | 0.1224 | 0.1264 | 0.5778 | 0.5265 | 0.0004 | 0.0004 | 0.0035 | 0.0151 | 0.0545 | 0.1053 | 0.0729 | 0.1062 | 0.6416 | |||
SK-BR-3 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 902 | 486 | 1571 | 8752 | 79.8 | 18.38 | 25.85 | 63.61 | 59 | 62 | 66 | 70 | 75 | 84 | 92 | 99 | 106 | 0.0978 | 856 | 0.759 | 104.01 | 24.21 | 3 | 0.1827 | 287 | 0.0137 | 2.82 | 4.627 | 0.5218 | 6709.4 | 592170 | 54600000 | 5230000000 | 0.4037 | 0.2309 | 0.0050 | 0.0000 | 0.0099 | 0.0000 | 0.0236 | 0.0000 | 0.0459 | 0.0067 | 0.0980 | 0.0299 | 0.1613 | 0.0552 | 0.1365 | 0.0579 | 0.1675 | 0.0685 | 0.3524 | 0.7818 | 0.0033 | 0.0000 | 0.0033 | 0.0000 | 0.0117 | 0.0000 | 0.0208 | 0.0045 | 0.0400 | 0.0248 | 0.0650 | 0.0446 | 0.0550 | 0.0299 | 0.0708 | 0.0350 | 0.7300 | 0.8611 | 0.0000 | 0.0299 | 0.0000 | 0.0746 | 0.0203 | 0.0597 | 0.0330 | 0.1642 | 0.0787 | 0.1045 | 0.1320 | 0.1493 | 0.1142 | 0.0746 | 0.1345 | 0.1194 | 0.4873 | 0.2239 | 0.0000 | 0.0057 | 0.0057 | 0.0213 | 0.0355 | 0.0682 | 0.0540 | 0.0753 | 0.7344 | 4 | 5 | 6 | 6 | 7 | 8 | 9 | 12 | 53 | 0.2949 | 7.14 | 2.200 | 0.6924 | 4714.0 | 1480000 | 590000000 | 281000000000 | 0.4076 | 0.1755 | 0.0603 | 0.0111 | 0.2915 | 0.0379 | 0.4824 | 0.1737 | 0.1407 | 0.2517 | 0.0101 | 0.2539 | 0.0101 | 0.1403 | 0.0050 | 0.0802 | 0.0000 | 0.0379 | 0.0000 | 0.0134 | 0.0008 | 0.0035 | 0.0041 | 0.0077 | 0.0154 | 0.0153 | 0.0170 | 0.0251 | 0.0519 | 0.0537 | 0.0787 | 0.0760 | 0.0463 | 0.0530 | 0.0779 | 0.0746 | 0.7078 | 0.6911 | 0.0019 | 0.0030 | 0.0039 | 0.0020 | 0.0048 | 0.0030 | 0.0087 | 0.0071 | 0.0571 | 0.0569 | 0.0871 | 0.0944 | 0.0600 | 0.0650 | 0.0794 | 0.0792 | 0.6970 | 0.6893 | 0.0018 | 0.0090 | 0.0045 | 0.0170 | 0.0502 | 0.0806 | 0.0556 | 0.0762 | 0.7052 | |
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 910 | 807 | 6848 | 30821 | 106.0 | 37.24 | 105.13 | 155.41 | 61 | 72 | 82 | 92 | 103 | 113 | 125 | 138 | 158 | 0.0405 | 1249 | 1.226 | 26.17 | 9.85 | 9 | 0.0098 | 67 | 0.0009 | 38.24 | 7.239 | 0.2025 | 12613.2 | 1650000 | 234000000 | 35100000000 | 0.4215 | 0.2066 | 0.0007 | 0.0002 | 0.0033 | 0.0008 | 0.0243 | 0.0026 | 0.0586 | 0.0134 | 0.1165 | 0.0469 | 0.1891 | 0.0968 | 0.1614 | 0.0907 | 0.1670 | 0.1146 | 0.2790 | 0.6340 | 0.0002 | 0.0002 | 0.0004 | 0.0005 | 0.0033 | 0.0010 | 0.0128 | 0.0060 | 0.0351 | 0.0237 | 0.0620 | 0.0451 | 0.0560 | 0.0361 | 0.0714 | 0.0516 | 0.7588 | 0.8358 | 0.0016 | 0.0031 | 0.0037 | 0.0020 | 0.0163 | 0.0224 | 0.0332 | 0.0755 | 0.0911 | 0.1337 | 0.1412 | 0.1714 | 0.0964 | 0.1378 | 0.1349 | 0.1265 | 0.4816 | 0.3276 | 0.0003 | 0.0025 | 0.0062 | 0.0192 | 0.0553 | 0.0812 | 0.0689 | 0.1066 | 0.6599 | 12 | 14 | 16 | 21 | 32 | 54 | 92 | 171 | 317 | 0.1725 | 11.92 | 3.893 | 0.6631 | 35203.0 | 18500000 | 12300000000 | 9820000000000 | 0.5391 | 0.1406 | 0.0742 | 0.0037 | 0.2097 | 0.0323 | 0.2157 | 0.1430 | 0.1346 | 0.1383 | 0.1226 | 0.1687 | 0.0935 | 0.1449 | 0.0677 | 0.1029 | 0.0452 | 0.1051 | 0.0369 | 0.1610 | 0.0005 | 0.0001 | 0.0016 | 0.0011 | 0.0034 | 0.0025 | 0.0160 | 0.0134 | 0.0667 | 0.0582 | 0.1011 | 0.0795 | 0.0708 | 0.0645 | 0.1073 | 0.0938 | 0.6325 | 0.6868 | 0.0003 | 0.0006 | 0.0014 | 0.0022 | 0.0048 | 0.0048 | 0.0257 | 0.0243 | 0.0784 | 0.0885 | 0.1231 | 0.1355 | 0.0842 | 0.0830 | 0.1184 | 0.1300 | 0.5638 | 0.5313 | 0.0004 | 0.0014 | 0.0037 | 0.0218 | 0.0770 | 0.1076 | 0.0837 | 0.1129 | 0.5915 | |
MCF 10A | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 726 | 600 | 3242 | 14311 | 499.5 | 83.43 | 217.74 | 192.04 | 394 | 426 | 450 | 470 | 493 | 518 | 547 | 576 | 612 | 0.0641 | 917 | 0.675 | 101.83 | 25.18 | 1 | 0.0999 | 324 | 0.0014 | 30.06 | 6.786 | 0.2232 | 256441.0 | 135000000 | 73000000000 | 40400000000000 | 0.4615 | 0.1909 | 0.0000 | 0.0000 | 0.0008 | 0.0000 | 0.0029 | 0.0003 | 0.0094 | 0.0019 | 0.0476 | 0.0128 | 0.1034 | 0.0350 | 0.0932 | 0.0172 | 0.1211 | 0.0428 | 0.6215 | 0.8900 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0007 | 0.0003 | 0.0031 | 0.0015 | 0.0241 | 0.0115 | 0.0544 | 0.0319 | 0.0457 | 0.0124 | 0.0582 | 0.0254 | 0.8139 | 0.9170 | 0.0069 | 0.2000 | 0.0185 | 0.2000 | 0.0254 | 0.1333 | 0.0762 | 0.2667 | 0.1224 | 0.0667 | 0.2517 | 0.1333 | 0.1201 | 0.0000 | 0.1386 | 0.0000 | 0.2402 | 0.0000 | 0.0026 | 0.0013 | 0.0110 | 0.0272 | 0.0725 | 0.1146 | 0.0881 | 0.1075 | 0.5751 | 27 | 59 | 91 | 117 | 149 | 197 | 277 | 373 | 502 | 0.0056 | 39.72 | 6.385 | 0.3525 | 84287.2 | 43400000 | 26300000000 | 17700000000000 | 0.5008 | 0.1648 | 0.0367 | 0.0032 | 0.1371 | 0.0092 | 0.2234 | 0.0566 | 0.1856 | 0.1095 | 0.1607 | 0.1802 | 0.1201 | 0.1909 | 0.0615 | 0.1404 | 0.0434 | 0.1268 | 0.0316 | 0.1831 | 0.0010 | 0.0008 | 0.0021 | 0.0015 | 0.0046 | 0.0040 | 0.0193 | 0.0143 | 0.0618 | 0.0534 | 0.0900 | 0.0837 | 0.0683 | 0.0638 | 0.1015 | 0.0908 | 0.6515 | 0.6878 | 0.0004 | 0.0008 | 0.0007 | 0.0042 | 0.0048 | 0.0124 | 0.0253 | 0.0287 | 0.0830 | 0.0944 | 0.1247 | 0.1404 | 0.1000 | 0.1138 | 0.1419 | 0.1548 | 0.5192 | 0.4506 | 0.0006 | 0.0023 | 0.0015 | 0.0250 | 0.0581 | 0.1139 | 0.0806 | 0.1154 | 0.6027 | |
MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 954 | 880 | 1679 | 5441 | 653.6 | 119.11 | 75.62 | 146.47 | 478 | 542 | 591 | 627 | 661 | 696 | 731 | 766 | 800 | 0.0884 | 481 | 0.755 | 132.23 | 36.35 | 1 | 0.2287 | 384 | 0.0009 | 82.04 | 7.094 | 0.1478 | 441315.0 | 307000000 | 218000000000 | 159000000000000 | 0.3946 | 0.2342 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0009 | 0.0000 | 0.0086 | 0.0018 | 0.0522 | 0.0283 | 0.0779 | 0.0361 | 0.0693 | 0.0307 | 0.1259 | 0.0451 | 0.6652 | 0.8581 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0021 | 0.0018 | 0.0313 | 0.0281 | 0.0392 | 0.0329 | 0.0271 | 0.0257 | 0.0499 | 0.0418 | 0.8504 | 0.8698 | 0.0042 | 0.0000 | 0.0169 | 0.0000 | 0.0254 | 0.0000 | 0.0424 | 0.0000 | 0.0890 | 0.0000 | 0.1271 | 0.0000 | 0.1144 | 0.0000 | 0.1271 | 0.0000 | 0.4534 | 0.0000 | 0.0011 | 0.0011 | 0.0034 | 0.0103 | 0.0525 | 0.0627 | 0.0490 | 0.0855 | 0.7343 | 7 | 9 | 11 | 13 | 17 | 28 | 60 | 104 | 173 | 0.0733 | 1.76 | 2.761 | 0.5531 | 27168.4 | 17800000 | 14800000000 | 13800000000000 | 0.4065 | 0.2202 | 0.0128 | 0.0026 | 0.0204 | 0.0102 | 0.0510 | 0.0269 | 0.1301 | 0.0409 | 0.1913 | 0.0882 | 0.2041 | 0.1317 | 0.1735 | 0.1228 | 0.1301 | 0.2008 | 0.0867 | 0.3760 | 0.0000 | 0.0000 | 0.0000 | 0.0016 | 0.0018 | 0.0027 | 0.0092 | 0.0070 | 0.0308 | 0.0271 | 0.0450 | 0.0411 | 0.0431 | 0.0319 | 0.0603 | 0.0541 | 0.8097 | 0.8343 | 0.0008 | 0.0009 | 0.0000 | 0.0019 | 0.0049 | 0.0075 | 0.0130 | 0.0160 | 0.0381 | 0.0479 | 0.0657 | 0.0695 | 0.0536 | 0.0638 | 0.0869 | 0.0892 | 0.7370 | 0.7033 | 0.0000 | 0.0063 | 0.0042 | 0.0105 | 0.0359 | 0.0450 | 0.0549 | 0.0703 | 0.7729 |