High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)

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Cell SM Name Small Mol Concentration Small Mol Conc Unit Other Reagent 1 Name Other Reagent 1 Detection Channel Other Reagent 2 Name Other Reagent 2 Detection Channel Row Column Field X-coordinate Y-coordinate Image Nuclear area (pixels) Cytoplasm area (pixels) Nuclear intensity (AU) Std Dev of nuclear intensity (AU) Cytoplasm intensity (AU) Std Dev of cytoplasm intensity (AU) 10% quantile of nuclear intensity (AU) 20% quantile of nuclear intensity (AU) 30% quantile of nuclear intensity (AU) 40% quantile of nuclear intensity (AU) 50% quantile of nuclear intensity (AU) 60% quantile of nuclear intensity (AU) 70% quantile of nuclear intensity (AU) 80% quantile of nuclear intensity (AU) 90% quantile of nuclear intensity (AU) Ratio of cytoplasm perimeter to area Cytoplasm perimeter (pixels) Nuclear roundness Nuclear length (pixels) Nuclear halfwidth (pixels) Number of nuclei Ratio of nuclear perimeter to area Nuclear perimeter (pixels) Nuclear Haralick ASM Nuclear Haralick contrast Nuclear Haralick entropy Nuclear Haralick IDM Nuclear Haralick moment 2 Nuclear Haralick moment 3 Nuclear Haralick moment 4 Nuclear Haralick moment 5 Nuclear radial moment (border) Nuclear radial moment (center) Nuclear Threshold Adj Stat 1 (Threshold: 0.2) Nuclear Threshold Adj Stat 1 (Threshold: 0.4) Nuclear Threshold Adj Stat 2 (Threshold: 0.2) Nuclear Threshold Adj Stat 2 (Threshold: 0.4) Nuclear Threshold Adj Stat 3 (Threshold: 0.2) Nuclear Threshold Adj Stat 3 (Threshold: 0.4) Nuclear Threshold Adj Stat 4 (Threshold: 0.2) Nuclear Threshold Adj Stat 4 (Threshold: 0.4) Nuclear Threshold Adj Stat 5 (Threshold: 0.2) Nuclear Threshold Adj Stat 5 (Threshold: 0.4) Nuclear Threshold Adj Stat 6 (Threshold: 0.2) Nuclear Threshold Adj Stat 6 (Threshold: 0.4) Nuclear Threshold Adj Stat 7 (Threshold: 0.2) Nuclear Threshold Adj Stat 7 (Threshold: 0.4) Nuclear Threshold Adj Stat 8 (Threshold: 0.2) Nuclear Threshold Adj Stat 8 (Threshold: 0.4) Nuclear Threshold Adj Stat 9 (Threshold: 0.2) Nuclear Threshold Adj Stat 9 (Threshold: 0.4) Nuclear Threshold Adj Stat 10 (Threshold: 0.2) Nuclear Threshold Adj Stat 10 (Threshold: 0.4) Nuclear Threshold Adj Stat 11 (Threshold: 0.2) Nuclear Threshold Adj Stat 11 (Threshold: 0.4) Nuclear Threshold Adj Stat 12 (Threshold: 0.2) Nuclear Threshold Adj Stat 12 (Threshold: 0.4) Nuclear Threshold Adj Stat 13 (Threshold: 0.2) Nuclear Threshold Adj Stat 13 (Threshold: 0.4) Nuclear Threshold Adj Stat 14 (Threshold: 0.2) Nuclear Threshold Adj Stat 14 (Threshold: 0.4) Nuclear Threshold Adj Stat 15 (Threshold: 0.2) Nuclear Threshold Adj Stat 15 (Threshold: 0.4) Nuclear Threshold Adj Stat 16 (Threshold: 0.2) Nuclear Threshold Adj Stat 16 (Threshold: 0.4) Nuclear Threshold Adj Stat 17 (Threshold: 0.2) Nuclear Threshold Adj Stat 17 (Threshold: 0.4) Nuclear Threshold Adj Stat 18 (Threshold: 0.2) Nuclear Threshold Adj Stat 18 (Threshold: 0.4) Nuclear Threshold Adj Stat 19 (Threshold: 0.2) Nuclear Threshold Adj Stat 19 (Threshold: 0.4) Nuclear Threshold Adj Stat 20 (Threshold: 0.2) Nuclear Threshold Adj Stat 20 (Threshold: 0.4) Nuclear Threshold Adj Stat 21 (Threshold: 0.2) Nuclear Threshold Adj Stat 21 (Threshold: 0.4) Nuclear Threshold Adj Stat 22 (Threshold: 0.2) Nuclear Threshold Adj Stat 22 (Threshold: 0.4) Nuclear Threshold Adj Stat 23 (Threshold: 0.2) Nuclear Threshold Adj Stat 23 (Threshold: 0.4) Nuclear Threshold Adj Stat 24 (Threshold: 0.2) Nuclear Threshold Adj Stat 24 (Threshold: 0.4) Nuclear Threshold Adj Stat 25 (Threshold: 0.2) Nuclear Threshold Adj Stat 25 (Threshold: 0.4) Nuclear Threshold Adj Stat 26 (Threshold: 0.2) Nuclear Threshold Adj Stat 26 (Threshold: 0.4) Nuclear Threshold Adj Stat 27 (Threshold: 0.2) Nuclear Threshold Adj Stat 27 (Threshold: 0.4) Nuclear Threshold Adj Stat 28 Nuclear Threshold Adj Stat 29 Nuclear Threshold Adj Stat 30 Nuclear Threshold Adj Stat 31 Nuclear Threshold Adj Stat 32 Nuclear Threshold Adj Stat 33 Nuclear Threshold Adj Stat 34 Nuclear Threshold Adj Stat 35 Nuclear Threshold Adj Stat 36 10% quantile of cytoplasm intensity (AU) 20% quantile of cytoplasm intensity (AU) 30% quantile of cytoplasm intensity (AU) 40% quantile of cytoplasm intensity (AU) 50% quantile of cytoplasm intensity (AU) 60% quantile of cytoplasm intensity (AU) 70% quantile of cytoplasm intensity (AU) 80% quantile of cytoplasm intensity (AU) 90% quantile of cytoplasm intensity (AU) Cytoplasmic Haralick ASM Cytoplasmic Haralick contrast Cytoplasmic Haralick entropy Cytoplasmic Haralick IDM Cytoplasmic Haralick moment 2 Cytoplasmic Haralick moment 3 Cytoplasmic Haralick moment 4 Cytoplasmic Haralick moment 5 Cytoplasmic radial moment (border) Cytoplasmic radial moment (center) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 28 Cytoplasmic Threshold Adj Stat 29 Cytoplasmic Threshold Adj Stat 30 Cytoplasmic Threshold Adj Stat 31 Cytoplasmic Threshold Adj Stat 32 Cytoplasmic Threshold Adj Stat 33 Cytoplasmic Threshold Adj Stat 34 Cytoplasmic Threshold Adj Stat 35 Cytoplasmic Threshold Adj Stat 36
MCF7 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 1052 727 image if available 435 10158 216.6 37.95 134.54 228.49 169 184 193 205 215 223 235 249 268 0.0475 483 1.039 156.49 50.48 1 0.9218 401 0.0052 14.90 5.415 0.3014 48369.5
11100000
2630000000
636000000000
0.4349 0.2080 0.0000 0.0000 0.0096 0.0000 0.0096 0.0000 0.0382 0.0047 0.1019 0.0606 0.1656 0.0629 0.1624 0.0606 0.1943 0.0956 0.3185 0.7156 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0186 0.0023 0.0849 0.0621 0.1088 0.0552 0.0928 0.0437 0.1432 0.0759 0.5517 0.7609 0.0000 0.1667 0.0000 0.0000 0.0635 0.1667 0.1905 0.3333 0.1429 0.3333 0.2540 0.0000 0.1270 0.0000 0.0635 0.0000 0.1587 0.0000 0.0000 0.0095 0.0237 0.0616 0.1754 0.1469 0.1280 0.1801 0.2749 5 7 8 9 11 16 98 264 495 0.1308 20.25 3.815 0.5357 70302.5
49000000
40900000000
40000000000000
0.5326 0.1283 0.0600 0.0028 0.2086 0.0308 0.2229 0.1413 0.2086 0.1636 0.1400 0.2070 0.0686 0.1930 0.0514 0.1035 0.0371 0.0867 0.0029 0.0713 0.0000 0.0000 0.0000 0.0000 0.0003 0.0000 0.0037 0.0047 0.0269 0.0233 0.0561 0.0472 0.0326 0.0315 0.0668 0.0585 0.8136 0.8348 0.0000 0.0000 0.0004 0.0004 0.0011 0.0020 0.0049 0.0053 0.0377 0.0422 0.0681 0.0763 0.0518 0.0666 0.0883 0.0849 0.7477 0.7223 0.0000 0.0000 0.0011 0.0029 0.0350 0.0622 0.0404 0.0733 0.7851
MDA-MB-231
0
DRAQ5 1 TMRE 2 2 2 1 1217 492 image if available 4158 8748 478.3 77.87 112.81 236.09 376 414 441 464 483 499 516 535 574 0.0725 634 0.983 79.31 27.31 1 0.0536 223 0.0016 22.49 6.757 0.2408 234837.0
118000000
60800000000
31900000000000
0.3975 0.2479 0.0000 0.0000 0.0003 0.0000 0.0003 0.0000 0.0070 0.0005 0.0263 0.0161 0.0444 0.0266 0.0456 0.0159 0.0702 0.0242 0.8058 0.9168 0.0000 0.0000 0.0003 0.0000 0.0000 0.0000 0.0030 0.0002 0.0174 0.0145 0.0277 0.0252 0.0261 0.0128 0.0397 0.0206 0.8859 0.9267 0.0048 0.0000 0.0048 0.0000 0.0096 0.0556 0.0264 0.0833 0.0769 0.1667 0.0817 0.1389 0.1082 0.1667 0.1034 0.1111 0.5841 0.2778 0.0014 0.0018 0.0063 0.0136 0.0407 0.0678 0.0691 0.0985 0.7010 5 7 8 9 10 12 22 146 413 0.1638 17.76 3.315 0.5824 68457.9
58700000
59900000000
68200000000000
0.3262 0.2943 0.0588 0.0025 0.2888 0.0296 0.2513 0.1605 0.1016 0.1951 0.1123 0.1975 0.0695 0.1383 0.1016 0.0864 0.0107 0.0963 0.0053 0.0938 0.0000 0.0000 0.0000 0.0009 0.0000 0.0005 0.0081 0.0076 0.0389 0.0360 0.0567 0.0536 0.0354 0.0337 0.0445 0.0469 0.8164 0.8208 0.0006 0.0006 0.0000 0.0012 0.0045 0.0041 0.0078 0.0088 0.0380 0.0364 0.0553 0.0634 0.0330 0.0346 0.0508 0.0511 0.8101 0.7999 0.0000 0.0000 0.0005 0.0123 0.0410 0.0511 0.0373 0.0453 0.8125
MCF7 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 710 226 image if available 10638 31624 385.7 96.25 128.74 201.92 261 301 330 358 383 410 437 468 511 0.0395 1248 1.125 80.96 32.70 1 0.0205 218 0.0007 46.96 7.474 0.1736 158052.0
68300000
30900000000
14600000000000
0.4592 0.1972 0.0007 0.0000 0.0012 0.0000 0.0092 0.0002 0.0215 0.0023 0.0807 0.0217 0.1548 0.0477 0.1521 0.0530 0.1775 0.0756 0.4023 0.7994 0.0004 0.0000 0.0006 0.0000 0.0029 0.0000 0.0071 0.0011 0.0308 0.0141 0.0563 0.0286 0.0517 0.0248 0.0718 0.0362 0.7784 0.8951 0.0031 0.0050 0.0093 0.0268 0.0194 0.0385 0.0552 0.1122 0.1254 0.2111 0.1762 0.1960 0.1219 0.1122 0.1524 0.1374 0.3370 0.1608 0.0006 0.0025 0.0046 0.0208 0.0594 0.1029 0.0892 0.1124 0.6077 6 7 8 10 13 26 121 273 445 0.1884 22.33 4.262 0.6114 57343.9
33100000
22000000000
16300000000000
0.4979 0.1312 0.0634 0.0031 0.2215 0.0274 0.3281 0.1449 0.1801 0.1860 0.1167 0.2111 0.0542 0.1939 0.0193 0.0950 0.0119 0.0923 0.0046 0.0464 0.0001 0.0002 0.0001 0.0007 0.0014 0.0009 0.0035 0.0033 0.0325 0.0296 0.0490 0.0435 0.0394 0.0311 0.0566 0.0537 0.8173 0.8370 0.0000 0.0000 0.0000 0.0004 0.0002 0.0006 0.0049 0.0057 0.0367 0.0435 0.0707 0.0771 0.0468 0.0543 0.0747 0.0844 0.7660 0.7341 0.0000 0.0002 0.0005 0.0052 0.0314 0.0597 0.0456 0.0609 0.7964
MDA-MB-231 A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 1140 501 image if available 2795 5688 534.4 104.94 43.08 68.58 388 442 474 506 538 572 599 634 676 0.0939 534 0.836 78.23 21.02 2 0.0733 205 0.0014 24.71 6.757 0.2480 296615.0
170000000
100000000000
60500000000000
0.4327 0.2031 0.0000 0.0000 0.0022 0.0004 0.0017 0.0000 0.0094 0.0007 0.0409 0.0211 0.0819 0.0324 0.0658 0.0200 0.0946 0.0328 0.7035 0.8926 0.0000 0.0000 0.0000 0.0004 0.0004 0.0000 0.0039 0.0007 0.0215 0.0211 0.0369 0.0324 0.0292 0.0200 0.0442 0.0298 0.8638 0.8956 0.0019 1.0000 0.0058 0.0000 0.0154 0.0000 0.0288 0.0000 0.0538 0.0000 0.1019 0.0000 0.0596 0.0000 0.0904 0.0000 0.6423 0.0000 0.0021 0.0014 0.0035 0.0174 0.0306 0.0542 0.0480 0.0618 0.7811 3 4 6 7 9 16 32 74 139 0.1144 4.30 3.672 0.6245 6558.9
1480000
411000000
131000000000
0.3466 0.2662 0.0039 0.0100 0.0656 0.0116 0.1467 0.0282 0.2625 0.0664 0.2625 0.1678 0.1931 0.1860 0.0618 0.1794 0.0039 0.1910 0.0000 0.1595 0.0006 0.0026 0.0012 0.0037 0.0000 0.0053 0.0078 0.0100 0.0246 0.0238 0.0414 0.0365 0.0402 0.0396 0.0618 0.0497 0.8224 0.8288 0.0000 0.0000 0.0007 0.0015 0.0007 0.0008 0.0092 0.0124 0.0348 0.0372 0.0540 0.0581 0.0511 0.0550 0.0724 0.0790 0.7770 0.7560 0.0000 0.0000 0.0026 0.0059 0.0315 0.0538 0.0446 0.0649 0.7967
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 461 123 image if available 3257 6809 514.7 105.53 61.25 124.20 368 433 474 500 525 551 579 608 638 0.0824 561 0.766 87.00 16.03 3 0.0620 202 0.0010 52.75 7.148 0.1825 276060.0
153000000
86800000000
50400000000000
0.4286 0.2196 0.0000 0.0000 0.0014 0.0000 0.0068 0.0000 0.0140 0.0013 0.0512 0.0198 0.0978 0.0406 0.0965 0.0227 0.1277 0.0373 0.6046 0.8782 0.0000 0.0000 0.0000 0.0000 0.0004 0.0000 0.0029 0.0013 0.0220 0.0197 0.0447 0.0384 0.0293 0.0184 0.0411 0.0288 0.8596 0.8934 0.0077 0.1333 0.0173 0.1333 0.0288 0.0667 0.0865 0.1333 0.1404 0.2667 0.1442 0.1333 0.1231 0.0000 0.1654 0.1333 0.2865 0.0000 0.0011 0.0023 0.0079 0.0186 0.0514 0.0814 0.0729 0.1040 0.6605 7 9 11 12 14 19 31 56 175 0.1883 7.43 3.201 0.7374 19174.6
10600000
7360000000
5780000000000
0.4921 0.1647 0.0338 0.0142 0.0549 0.0252 0.0717 0.0377 0.0928 0.0660 0.1392 0.0849 0.1814 0.1289 0.2363 0.1321 0.1097 0.1525 0.0802 0.3585 0.0034 0.0045 0.0048 0.0078 0.0034 0.0111 0.0109 0.0167 0.0212 0.0279 0.0519 0.0507 0.0355 0.0423 0.0444 0.0591 0.8245 0.7799 0.0000 0.0000 0.0008 0.0000 0.0016 0.0000 0.0073 0.0078 0.0334 0.0336 0.0465 0.0509 0.0302 0.0259 0.0522 0.0578 0.8280 0.8240 0.0008 0.0008 0.0046 0.0106 0.0236 0.0540 0.0274 0.0547 0.8237
SK-BR-3 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 1108 239 image if available 5108 12529 286.7 70.87 214.74 352.40 171 236 266 284 299 315 328 344 365 0.0797 998 0.558 111.13 15.52 4 0.0484 247 0.0020 16.33 6.555 0.2615 87243.0
27600000
9000000000
3000000000000
0.3894 0.2353 0.0003 0.0000 0.0013 0.0000 0.0025 0.0004 0.0143 0.0011 0.0584 0.0180 0.0901 0.0332 0.0841 0.0276 0.1336 0.0427 0.6155 0.8769 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0005 0.0007 0.0180 0.0141 0.0245 0.0255 0.0159 0.0137 0.0327 0.0196 0.9084 0.9264 0.0060 0.0200 0.0109 0.1000 0.0268 0.1400 0.0625 0.1500 0.1240 0.1900 0.1488 0.1800 0.1399 0.1200 0.1290 0.0700 0.3522 0.0300 0.0013 0.0007 0.0040 0.0131 0.0368 0.0646 0.0703 0.1078 0.7014 8 10 13 17 22 32 138 460 810 0.1100 11.85 3.914 0.5579 170291.0
167000000
181000000000
211000000000000
0.5996 0.0926 0.0347 0.0084 0.1262 0.0139 0.2429 0.0446 0.1767 0.0990 0.2019 0.1660 0.1703 0.2106 0.0315 0.1381 0.0126 0.1367 0.0032 0.1827 0.0006 0.0000 0.0006 0.0000 0.0014 0.0003 0.0037 0.0024 0.0292 0.0286 0.0404 0.0329 0.0388 0.0347 0.0584 0.0583 0.8270 0.8428 0.0000 0.0006 0.0000 0.0010 0.0012 0.0003 0.0040 0.0055 0.0339 0.0372 0.0456 0.0486 0.0395 0.0466 0.0688 0.0696 0.8070 0.7905 0.0000 0.0000 0.0006 0.0038 0.0337 0.0391 0.0399 0.0609 0.8219
MDA-MB-231 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 708 397 image if available 15447 27394 562.4 113.78 118.30 212.73 394 458 507 542 576 606 636 667 703 0.0495 1356 0.896 108.19 30.00 3 0.0188 291 0.0006 29.72 7.605 0.2191 329218.0
199000000
124000000000
78600000000000
0.3988 0.2308 0.0014 0.0000 0.0019 0.0001 0.0040 0.0004 0.0105 0.0011 0.0269 0.0087 0.0473 0.0169 0.0485 0.0102 0.0672 0.0157 0.7922 0.9469 0.0001 0.0000 0.0002 0.0000 0.0005 0.0001 0.0023 0.0010 0.0107 0.0080 0.0188 0.0166 0.0160 0.0091 0.0204 0.0143 0.9310 0.9510 0.0029 0.0000 0.0095 0.0179 0.0147 0.0536 0.0297 0.1607 0.0612 0.1250 0.0718 0.1071 0.0872 0.2500 0.1213 0.1071 0.6015 0.1786 0.0008 0.0010 0.0032 0.0069 0.0226 0.0401 0.0411 0.0534 0.8309 7 9 10 11 12 15 40 206 467 0.3132 20.18 3.462 0.7115 59247.2
38200000
27600000000
21600000000000
0.5023 0.1444 0.0436 0.0036 0.1336 0.0128 0.2377 0.1026 0.1744 0.1354 0.1547 0.1810 0.1069 0.1882 0.0675 0.1055 0.0520 0.1119 0.0295 0.1589 0.0000 0.0003 0.0003 0.0004 0.0010 0.0004 0.0058 0.0038 0.0203 0.0189 0.0418 0.0353 0.0301 0.0220 0.0517 0.0418 0.8491 0.8771 0.0000 0.0000 0.0006 0.0005 0.0003 0.0005 0.0058 0.0079 0.0263 0.0302 0.0558 0.0631 0.0452 0.0492 0.0622 0.0705 0.8037 0.7782 0.0000 0.0000 0.0006 0.0049 0.0263 0.0486 0.0405 0.0571 0.8221
MDA-MB-231 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 187 499 image if available 5159 11813 530.2 150.73 46.53 99.31 336 405 473 515 555 600 635 664 696 0.0781 923 1.105 73.82 25.55 4 0.0382 197 0.0006 44.92 7.570 0.1925 303806.0
182000000
112000000000
70800000000000
0.3690 0.2568 0.0020 0.0000 0.0029 0.0000 0.0069 0.0004 0.0167 0.0024 0.0587 0.0163 0.0953 0.0308 0.0843 0.0238 0.1059 0.0400 0.6273 0.8863 0.0005 0.0000 0.0002 0.0000 0.0007 0.0000 0.0025 0.0021 0.0185 0.0146 0.0285 0.0275 0.0217 0.0173 0.0307 0.0266 0.8966 0.9119 0.0019 0.0635 0.0052 0.0476 0.0110 0.1270 0.0213 0.1429 0.0549 0.0635 0.0614 0.1270 0.0627 0.0952 0.1008 0.1270 0.6807 0.2063 0.0010 0.0024 0.0038 0.0076 0.0244 0.0344 0.0337 0.0485 0.8443 6 8 9 10 11 13 17 52 137 0.1781 7.69 3.150 0.7073 12026.7
6360000
4770000000
4300000000000
0.4827 0.1912 0.0208 0.0043 0.0655 0.0157 0.1042 0.0386 0.1548 0.0815 0.1935 0.1302 0.1905 0.1774 0.1488 0.1245 0.0893 0.1660 0.0327 0.2618 0.0004 0.0007 0.0004 0.0018 0.0011 0.0036 0.0042 0.0075 0.0229 0.0220 0.0362 0.0341 0.0320 0.0242 0.0526 0.0512 0.8502 0.8550 0.0000 0.0000 0.0022 0.0019 0.0044 0.0033 0.0079 0.0071 0.0271 0.0288 0.0411 0.0506 0.0389 0.0378 0.0599 0.0624 0.8186 0.8080 0.0000 0.0012 0.0032 0.0085 0.0263 0.0388 0.0324 0.0599 0.8297
MCF7
0
DRAQ5 1 TMRE 2 2 2 1 307 284 image if available 4454 15705 541.8 126.10 114.66 191.51 395 434 463 491 521 551 591 651 728 0.0554 870 1.060 102.88 27.59 2 0.0534 238 0.0008 82.33 7.369 0.1665 309466.0
186000000
118000000000
78000000000000
0.4066 0.2345 0.0007 0.0000 0.0030 0.0000 0.0097 0.0005 0.0157 0.0027 0.0737 0.0261 0.1377 0.0438 0.1448 0.0443 0.1534 0.0597 0.4611 0.8229 0.0003 0.0000 0.0000 0.0000 0.0011 0.0000 0.0056 0.0002 0.0407 0.0161 0.0709 0.0258 0.0709 0.0192 0.0895 0.0269 0.7210 0.9117 0.0022 0.0032 0.0000 0.0160 0.0078 0.0415 0.0526 0.0927 0.0973 0.1629 0.1353 0.1502 0.0839 0.1086 0.1074 0.1438 0.5134 0.2812 0.0000 0.0031 0.0062 0.0333 0.0868 0.1149 0.1004 0.1108 0.5445 5 7 8 10 11 17 98 220 400 0.1818 28.75 4.115 0.6043 49820.4
29100000
19900000000
15300000000000
0.3528 0.2965 0.0222 0.0027 0.0974 0.0054 0.2530 0.0467 0.2085 0.0916 0.1880 0.2163 0.1333 0.2720 0.0496 0.1517 0.0222 0.1086 0.0256 0.1050 0.0000 0.0000 0.0002 0.0002 0.0010 0.0002 0.0025 0.0028 0.0223 0.0206 0.0377 0.0307 0.0289 0.0256 0.0466 0.0365 0.8607 0.8834 0.0005 0.0003 0.0002 0.0005 0.0002 0.0005 0.0059 0.0071 0.0334 0.0374 0.0541 0.0695 0.0498 0.0450 0.0636 0.0730 0.7923 0.7666 0.0002 0.0000 0.0004 0.0042 0.0271 0.0491 0.0391 0.0560 0.8237
MDA-MB-231 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 100 607 image if available 540 5580 379.2 43.12 73.69 167.23 318 337 353 372 384 393 405 418 436 0.0710 396 0.750 109.88 35.01 2 0.6222 336 0.0034 25.50 5.823 0.2191 145633.0
56600000
22300000000
8850000000000
0.3869 0.2443 0.0000 0.0000 0.0000 0.0000 0.0020 0.0000 0.0080 0.0019 0.0459 0.0426 0.0719 0.0630 0.0599 0.0315 0.0719 0.0537 0.7405 0.8074 0.0000 0.0000 0.0000 0.0000 0.0019 0.0000 0.0039 0.0019 0.0426 0.0426 0.0638 0.0630 0.0329 0.0315 0.0561 0.0537 0.7988 0.8074 0.0000 0.0000 0.0000 0.0000 0.0625 0.0000 0.1250 0.0000 0.4375 0.0000 0.0625 0.0000 0.2500 0.0000 0.0625 0.0000 0.0000 0.0000 0.0000 0.0000 0.0069 0.0241 0.0552 0.0897 0.0828 0.1276 0.6138 10 13 15 17 20 25 42 99 162 0.2249 3.67 2.655 0.7483 33390.0
36400000
52700000000
84800000000000
0.5879 0.1256 0.0385 0.0052 0.0427 0.0174 0.1026 0.0261 0.1880 0.0540 0.2222 0.1237 0.1624 0.1429 0.1496 0.1655 0.0684 0.2003 0.0256 0.2648 0.0007 0.0018 0.0014 0.0043 0.0027 0.0037 0.0075 0.0043 0.0177 0.0178 0.0198 0.0227 0.0355 0.0233 0.0539 0.0491 0.8608 0.8729 0.0000 0.0038 0.0000 0.0028 0.0000 0.0066 0.0154 0.0227 0.0292 0.0360 0.0382 0.0588 0.0544 0.0682 0.1072 0.0986 0.7555 0.7024 0.0007 0.0007 0.0029 0.0059 0.0192 0.0354 0.0347 0.0560 0.8444
MCF7 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 841 100 image if available 7377 24941 386.3 96.75 88.88 190.82 262 298 330 360 385 408 433 466 515 0.0500 1246 0.563 94.76 26.17 2 0.0409 302 0.0008 47.55 7.415 0.1751 158588.0
68800000
31400000000
15000000000000
0.4311 0.2177 0.0002 0.0000 0.0031 0.0005 0.0070 0.0012 0.0283 0.0041 0.0813 0.0252 0.1505 0.0529 0.1401 0.0558 0.1607 0.0799 0.4286 0.7805 0.0000 0.0000 0.0011 0.0001 0.0023 0.0003 0.0099 0.0018 0.0340 0.0163 0.0593 0.0332 0.0508 0.0272 0.0661 0.0402 0.7764 0.8808 0.0040 0.0130 0.0066 0.0238 0.0139 0.0563 0.0615 0.0909 0.1315 0.1970 0.1606 0.1710 0.1269 0.1255 0.1401 0.1299 0.3549 0.1926 0.0005 0.0014 0.0043 0.0220 0.0674 0.1016 0.1003 0.1272 0.5753 4 5 7 8 10 12 18 103 322 0.1971 13.23 3.393 0.6457 44309.3
31100000
25500000000
23000000000000
0.4510 0.1554 0.0309 0.0028 0.1373 0.0130 0.2921 0.0763 0.2205 0.1516 0.1431 0.2140 0.0986 0.1898 0.0271 0.1395 0.0213 0.1116 0.0290 0.1014 0.0000 0.0003 0.0009 0.0005 0.0007 0.0016 0.0037 0.0063 0.0213 0.0191 0.0374 0.0318 0.0250 0.0278 0.0407 0.0377 0.8703 0.8748 0.0000 0.0002 0.0008 0.0004 0.0004 0.0019 0.0063 0.0064 0.0259 0.0282 0.0468 0.0526 0.0377 0.0404 0.0539 0.0614 0.8281 0.8084 0.0000 0.0004 0.0008 0.0042 0.0213 0.0423 0.0293 0.0477 0.8540
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 259 595 image if available 3281 8845 537.2 98.78 47.70 69.98 406 455 487 513 535 555 578 608 681 0.0684 605 1.005 109.84 37.48 2 0.0884 290 0.0012 24.77 6.942 0.2330 298323.0
171000000
101000000000
61500000000000
0.4559 0.1915 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0076 0.0006 0.0295 0.0159 0.0565 0.0312 0.0510 0.0243 0.0674 0.0328 0.7880 0.8952 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0039 0.0006 0.0159 0.0128 0.0297 0.0253 0.0244 0.0131 0.0304 0.0186 0.8956 0.9295 0.0066 0.0137 0.0088 0.0274 0.0243 0.0959 0.0133 0.0959 0.0575 0.2055 0.0973 0.1507 0.0619 0.1096 0.0841 0.1507 0.6460 0.1507 0.0012 0.0000 0.0025 0.0204 0.0532 0.0835 0.0884 0.1070 0.6438 8 9 11 12 14 19 46 78 131 0.2066 2.60 3.143 0.7617 7171.8
1810000
603000000
239000000000
0.5155 0.1378 0.0352 0.0029 0.0580 0.0155 0.0890 0.0638 0.1201 0.0629 0.1532 0.0977 0.1636 0.1460 0.1822 0.1199 0.1387 0.1586 0.0600 0.3327 0.0007 0.0007 0.0014 0.0020 0.0021 0.0029 0.0064 0.0085 0.0152 0.0186 0.0258 0.0232 0.0237 0.0235 0.0488 0.0405 0.8759 0.8803 0.0017 0.0015 0.0009 0.0039 0.0064 0.0064 0.0111 0.0148 0.0273 0.0261 0.0413 0.0542 0.0388 0.0473 0.0725 0.0719 0.8001 0.7740 0.0008 0.0008 0.0035 0.0096 0.0207 0.0261 0.0337 0.0560 0.8489
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 561 247 image if available 4445 15033 466.1 65.09 63.62 138.06 379 413 433 450 466 481 499 521 551 0.0559 840 1.186 46.40 17.49 1 0.0270 120 0.0015 34.76 6.820 0.2169 221513.0
107000000
52800000000
26400000000000
0.4116 0.2311 0.0000 0.0000 0.0000 0.0000 0.0011 0.0000 0.0035 0.0002 0.0355 0.0137 0.0646 0.0248 0.0635 0.0142 0.0910 0.0205 0.7407 0.9266 0.0000 0.0000 0.0000 0.0000 0.0002 0.0000 0.0020 0.0002 0.0221 0.0137 0.0368 0.0248 0.0314 0.0142 0.0456 0.0187 0.8620 0.9284 0.0110 1.0000 0.0192 0.0000 0.0219 0.0000 0.0959 0.0000 0.1479 0.0000 0.1726 0.0000 0.1397 0.0000 0.1288 0.0000 0.2630 0.0000 0.0004 0.0036 0.0085 0.0278 0.0732 0.0996 0.0961 0.1302 0.5606 7 8 9 10 12 15 22 57 200 0.2619 11.61 3.053 0.7574 23105.5
14100000
11000000000
10100000000000
0.4691 0.1844 0.0363 0.0081 0.0726 0.0208 0.0726 0.0728 0.1501 0.0786 0.1622 0.1110 0.1671 0.1260 0.1574 0.1191 0.1090 0.1445 0.0726 0.3191 0.0003 0.0012 0.0013 0.0030 0.0023 0.0044 0.0077 0.0094 0.0229 0.0195 0.0265 0.0301 0.0245 0.0248 0.0368 0.0387 0.8777 0.8689 0.0011 0.0000 0.0011 0.0004 0.0022 0.0024 0.0108 0.0091 0.0238 0.0234 0.0309 0.0313 0.0313 0.0317 0.0395 0.0527 0.8593 0.8490 0.0003 0.0007 0.0048 0.0104 0.0214 0.0308 0.0235 0.0443 0.8637
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 568 142 image if available 3390 3676 488.2 76.89 55.99 95.47 384 420 448 473 493 513 533 556 587 0.1317 484 0.859 109.18 23.32 5 0.0752 255 0.0012 41.51 6.959 0.2091 244289.0
125000000
65200000000
34600000000000
0.4456 0.2022 0.0000 0.0000 0.0000 0.0000 0.0019 0.0000 0.0133 0.0009 0.0451 0.0139 0.0863 0.0237 0.0833 0.0160 0.1064 0.0261 0.6638 0.9194 0.0000 0.0000 0.0000 0.0000 0.0003 0.0000 0.0050 0.0009 0.0220 0.0139 0.0441 0.0237 0.0414 0.0154 0.0588 0.0231 0.8284 0.9230 0.0028 0.0000 0.0113 1.0000 0.0395 0.0000 0.1073 0.0000 0.1638 0.0000 0.2147 0.0000 0.1243 0.0000 0.1356 0.0000 0.2006 0.0000 0.0006 0.0017 0.0045 0.0195 0.0658 0.1155 0.1016 0.1267 0.5642 9 11 12 14 17 20 25 75 169 0.1554 6.68 3.147 0.7267 12247.2
4240000
1770000000
834000000000
0.4752 0.1492 0.0192 0.0284 0.0769 0.0355 0.1731 0.1277 0.3462 0.1489 0.1346 0.1915 0.1346 0.1773 0.1154 0.1206 0.0000 0.0709 0.0000 0.0993 0.0000 0.0046 0.0025 0.0058 0.0012 0.0116 0.0037 0.0127 0.0160 0.0197 0.0197 0.0313 0.0271 0.0174 0.0406 0.0440 0.8892 0.8530 0.0000 0.0000 0.0000 0.0000 0.0026 0.0028 0.0039 0.0083 0.0211 0.0221 0.0316 0.0456 0.0395 0.0415 0.0684 0.0692 0.8329 0.8105 0.0000 0.0000 0.0013 0.0038 0.0189 0.0215 0.0278 0.0556 0.8712