High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
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| Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
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| MCF7 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 1246 | 203 | | 5974 | 10831 | 309.6 | 60.88 | 229.94 | 346.15 | 229 | 256 | 278 | 295 | 310 | 324 | 340 | 361 | 389 | 0.0792 | 858 | 0.570 | 89.36 | 14.42 | 1 | 0.0336 | 201 | 0.0010 | 42.49 | 7.110 | 0.1903 | 99557.1 | 33100000 | 11400000000 | 4030000000000 | 0.4350 | 0.2143 | 0.0005 | 0.0000 | 0.0005 | 0.0003 | 0.0049 | 0.0003 | 0.0155 | 0.0019 | 0.0608 | 0.0167 | 0.1043 | 0.0263 | 0.1316 | 0.0288 | 0.1592 | 0.0436 | 0.5228 | 0.8820 | 0.0004 | 0.0000 | 0.0002 | 0.0003 | 0.0010 | 0.0003 | 0.0058 | 0.0014 | 0.0243 | 0.0127 | 0.0467 | 0.0199 | 0.0505 | 0.0136 | 0.0664 | 0.0216 | 0.8047 | 0.9302 | 0.0043 | 0.0274 | 0.0228 | 0.0479 | 0.0390 | 0.0548 | 0.1029 | 0.1644 | 0.1484 | 0.1986 | 0.1582 | 0.1712 | 0.1387 | 0.1164 | 0.1278 | 0.1370 | 0.2579 | 0.0822 | 0.0007 | 0.0027 | 0.0050 | 0.0219 | 0.0757 | 0.1286 | 0.1173 | 0.1591 | 0.4890 | 4 | 7 | 9 | 12 | 19 | 103 | 267 | 475 | 758 | 0.0830 | 58.23 | 4.859 | 0.4659 | 172683.0 | 171000000 | 200000000000 | 267000000000000 | 0.3514 | 0.2613 | 0.0254 | 0.0000 | 0.1404 | 0.0131 | 0.2860 | 0.0672 | 0.2014 | 0.1345 | 0.1726 | 0.1921 | 0.0660 | 0.2192 | 0.0609 | 0.1432 | 0.0220 | 0.1188 | 0.0254 | 0.1118 | 0.0000 | 0.0000 | 0.0003 | 0.0010 | 0.0008 | 0.0010 | 0.0074 | 0.0049 | 0.0296 | 0.0227 | 0.0565 | 0.0462 | 0.0486 | 0.0366 | 0.0600 | 0.0545 | 0.7969 | 0.8332 | 0.0003 | 0.0000 | 0.0003 | 0.0017 | 0.0022 | 0.0034 | 0.0078 | 0.0112 | 0.0441 | 0.0454 | 0.0789 | 0.0919 | 0.0582 | 0.0671 | 0.0851 | 0.0824 | 0.7230 | 0.6969 | 0.0006 | 0.0009 | 0.0017 | 0.0086 | 0.0356 | 0.0710 | 0.0529 | 0.0690 | 0.7597 |
| MCF7 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 477 | 426 | | 5377 | 19317 | 581.1 | 160.29 | 136.17 | 209.41 | 425 | 459 | 484 | 509 | 534 | 566 | 617 | 705 | 822 | 0.0467 | 902 | 1.031 | 97.32 | 27.29 | 2 | 0.0433 | 233 | 0.0008 | 63.73 | 7.412 | 0.1708 | 363397.0 | 246000000 | 181000000000 | 144000000000000 | 0.3855 | 0.2619 | 0.0003 | 0.0000 | 0.0003 | 0.0000 | 0.0029 | 0.0002 | 0.0165 | 0.0025 | 0.0836 | 0.0253 | 0.1454 | 0.0498 | 0.1535 | 0.0451 | 0.1707 | 0.0641 | 0.4266 | 0.8129 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0007 | 0.0000 | 0.0048 | 0.0002 | 0.0452 | 0.0152 | 0.0767 | 0.0238 | 0.0829 | 0.0208 | 0.1093 | 0.0315 | 0.6802 | 0.9084 | 0.0018 | 0.0000 | 0.0018 | 0.0068 | 0.0063 | 0.0068 | 0.0288 | 0.0342 | 0.0728 | 0.1182 | 0.1150 | 0.1541 | 0.0584 | 0.0908 | 0.0988 | 0.1404 | 0.6164 | 0.4486 | 0.0015 | 0.0026 | 0.0128 | 0.0271 | 0.0767 | 0.1048 | 0.0772 | 0.0905 | 0.6069 | 6 | 8 | 9 | 12 | 19 | 59 | 148 | 254 | 436 | 0.1238 | 34.07 | 4.718 | 0.5673 | 62391.7 | 40700000 | 33200000000 | 32300000000000 | 0.4255 | 0.1972 | 0.0345 | 0.0023 | 0.1373 | 0.0110 | 0.2596 | 0.0799 | 0.2092 | 0.1106 | 0.1690 | 0.2037 | 0.1018 | 0.1992 | 0.0495 | 0.1293 | 0.0271 | 0.1275 | 0.0121 | 0.1366 | 0.0003 | 0.0000 | 0.0005 | 0.0001 | 0.0009 | 0.0000 | 0.0059 | 0.0038 | 0.0367 | 0.0320 | 0.0589 | 0.0488 | 0.0443 | 0.0411 | 0.0677 | 0.0553 | 0.7847 | 0.8190 | 0.0002 | 0.0002 | 0.0002 | 0.0014 | 0.0007 | 0.0008 | 0.0100 | 0.0122 | 0.0407 | 0.0531 | 0.0851 | 0.0882 | 0.0557 | 0.0635 | 0.0838 | 0.0904 | 0.7235 | 0.6902 | 0.0000 | 0.0000 | 0.0005 | 0.0065 | 0.0403 | 0.0668 | 0.0522 | 0.0737 | 0.7600 | ||
| MCF7 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 503 | 432 | | 11808 | 33332 | 318.9 | 77.36 | 142.89 | 210.03 | 224 | 252 | 274 | 294 | 313 | 332 | 354 | 382 | 421 | 0.0347 | 1158 | 1.075 | 96.88 | 32.00 | 1 | 0.0204 | 241 | 0.0011 | 35.28 | 7.136 | 0.2018 | 107664.0 | 38400000 | 14400000000 | 5670000000000 | 0.4385 | 0.2096 | 0.0001 | 0.0000 | 0.0004 | 0.0000 | 0.0068 | 0.0004 | 0.0240 | 0.0021 | 0.0823 | 0.0190 | 0.1435 | 0.0483 | 0.1432 | 0.0507 | 0.1608 | 0.0696 | 0.4388 | 0.8100 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0015 | 0.0002 | 0.0071 | 0.0012 | 0.0317 | 0.0115 | 0.0656 | 0.0250 | 0.0600 | 0.0226 | 0.0788 | 0.0331 | 0.7553 | 0.9064 | 0.0047 | 0.0040 | 0.0064 | 0.0162 | 0.0180 | 0.0324 | 0.0588 | 0.1309 | 0.1171 | 0.1646 | 0.1656 | 0.2146 | 0.1257 | 0.1242 | 0.1416 | 0.1026 | 0.3621 | 0.2105 | 0.0020 | 0.0023 | 0.0069 | 0.0236 | 0.0705 | 0.1235 | 0.0941 | 0.1163 | 0.5608 | 6 | 7 | 9 | 11 | 20 | 67 | 166 | 292 | 458 | 0.1413 | 28.98 | 4.701 | 0.5652 | 64528.1 | 40100000 | 31100000000 | 29500000000000 | 0.4198 | 0.2297 | 0.0409 | 0.0008 | 0.1490 | 0.0130 | 0.2877 | 0.0770 | 0.1876 | 0.1317 | 0.1496 | 0.1991 | 0.0863 | 0.2098 | 0.0489 | 0.1278 | 0.0334 | 0.1018 | 0.0167 | 0.1390 | 0.0000 | 0.0000 | 0.0003 | 0.0003 | 0.0009 | 0.0007 | 0.0046 | 0.0041 | 0.0332 | 0.0264 | 0.0586 | 0.0502 | 0.0443 | 0.0368 | 0.0677 | 0.0562 | 0.7904 | 0.8252 | 0.0000 | 0.0002 | 0.0003 | 0.0008 | 0.0015 | 0.0014 | 0.0069 | 0.0086 | 0.0446 | 0.0485 | 0.0792 | 0.0935 | 0.0610 | 0.0660 | 0.0897 | 0.0966 | 0.7168 | 0.6842 | 0.0000 | 0.0006 | 0.0008 | 0.0069 | 0.0372 | 0.0677 | 0.0539 | 0.0771 | 0.7557 |
| MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1219 | 611 | | 6727 | 10795 | 500.4 | 87.18 | 61.57 | 164.61 | 389 | 436 | 464 | 484 | 500 | 519 | 539 | 564 | 613 | 0.0766 | 827 | 0.887 | 151.21 | 35.90 | 4 | 0.0523 | 352 | 0.0010 | 40.11 | 7.197 | 0.1973 | 258004.0 | 137000000 | 74100000000 | 41200000000000 | 0.4599 | 0.1961 | 0.0006 | 0.0000 | 0.0008 | 0.0000 | 0.0006 | 0.0000 | 0.0061 | 0.0005 | 0.0334 | 0.0138 | 0.0743 | 0.0305 | 0.0688 | 0.0200 | 0.0981 | 0.0361 | 0.7174 | 0.8992 | 0.0003 | 0.0000 | 0.0003 | 0.0000 | 0.0002 | 0.0000 | 0.0020 | 0.0002 | 0.0203 | 0.0122 | 0.0431 | 0.0268 | 0.0321 | 0.0141 | 0.0475 | 0.0242 | 0.8540 | 0.9226 | 0.0036 | 0.0385 | 0.0109 | 0.0641 | 0.0243 | 0.0256 | 0.0510 | 0.1282 | 0.0875 | 0.2179 | 0.1179 | 0.2179 | 0.0899 | 0.1026 | 0.1118 | 0.1026 | 0.5030 | 0.1026 | 0.0015 | 0.0026 | 0.0100 | 0.0280 | 0.0665 | 0.1130 | 0.0971 | 0.1266 | 0.5546 | 5 | 5 | 7 | 8 | 9 | 10 | 12 | 20 | 145 | 0.3474 | 14.59 | 2.480 | 0.7590 | 30885.0 | 22100000 | 18100000000 | 16500000000000 | 0.6221 | 0.0747 | 0.0404 | 0.0026 | 0.1515 | 0.0289 | 0.2172 | 0.0525 | 0.2071 | 0.1732 | 0.1515 | 0.2310 | 0.1414 | 0.2047 | 0.0505 | 0.1260 | 0.0303 | 0.0866 | 0.0101 | 0.0945 | 0.0000 | 0.0006 | 0.0006 | 0.0030 | 0.0032 | 0.0024 | 0.0121 | 0.0119 | 0.0401 | 0.0351 | 0.0650 | 0.0660 | 0.0510 | 0.0463 | 0.0643 | 0.0564 | 0.7637 | 0.7784 | 0.0000 | 0.0000 | 0.0015 | 0.0015 | 0.0015 | 0.0038 | 0.0175 | 0.0215 | 0.0445 | 0.0445 | 0.0729 | 0.0722 | 0.0590 | 0.0507 | 0.0649 | 0.0753 | 0.7383 | 0.7304 | 0.0000 | 0.0014 | 0.0020 | 0.0143 | 0.0442 | 0.0626 | 0.0558 | 0.0721 | 0.7476 |
| SK-BR-3 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 524 | 311 | | 7833 | 16316 | 159.4 | 129.05 | 84.65 | 174.06 | 65 | 76 | 86 | 97 | 114 | 131 | 150 | 185 | 382 | 0.0834 | 1360 | 1.188 | 60.96 | 23.71 | 5 | 0.0200 | 157 | 0.0057 | 7.18 | 5.903 | 0.4831 | 42052.4 | 16100000 | 7440000000 | 3750000000000 | 0.4134 | 0.2024 | 0.0022 | 0.0044 | 0.0039 | 0.0032 | 0.0061 | 0.0041 | 0.0335 | 0.0116 | 0.0754 | 0.0367 | 0.0972 | 0.0576 | 0.0972 | 0.0547 | 0.1056 | 0.0789 | 0.5788 | 0.7488 | 0.0012 | 0.0031 | 0.0021 | 0.0023 | 0.0027 | 0.0029 | 0.0140 | 0.0079 | 0.0273 | 0.0211 | 0.0334 | 0.0280 | 0.0404 | 0.0320 | 0.0507 | 0.0445 | 0.8282 | 0.8580 | 0.0007 | 0.0000 | 0.0007 | 0.0000 | 0.0033 | 0.0000 | 0.0086 | 0.0022 | 0.0213 | 0.0230 | 0.0452 | 0.0445 | 0.0219 | 0.0208 | 0.0359 | 0.0408 | 0.8625 | 0.8687 | 0.0005 | 0.0039 | 0.0043 | 0.0096 | 0.0294 | 0.0487 | 0.0352 | 0.0545 | 0.8140 | 8 | 10 | 12 | 15 | 18 | 24 | 39 | 87 | 242 | 0.1992 | 8.64 | 2.988 | 0.7068 | 37461.6 | 26400000 | 22100000000 | 20600000000000 | 0.5330 | 0.1352 | 0.0090 | 0.0029 | 0.0336 | 0.0070 | 0.0493 | 0.0187 | 0.1087 | 0.0531 | 0.1659 | 0.0904 | 0.1839 | 0.1376 | 0.1390 | 0.1405 | 0.1312 | 0.1359 | 0.1794 | 0.4140 | 0.0005 | 0.0009 | 0.0029 | 0.0023 | 0.0029 | 0.0042 | 0.0098 | 0.0168 | 0.0383 | 0.0349 | 0.0554 | 0.0519 | 0.0449 | 0.0496 | 0.0660 | 0.0575 | 0.7794 | 0.7817 | 0.0021 | 0.0004 | 0.0017 | 0.0035 | 0.0045 | 0.0047 | 0.0141 | 0.0116 | 0.0497 | 0.0520 | 0.0783 | 0.0849 | 0.0583 | 0.0621 | 0.0852 | 0.0791 | 0.7060 | 0.7017 | 0.0009 | 0.0033 | 0.0045 | 0.0117 | 0.0415 | 0.0667 | 0.0505 | 0.0739 | 0.7471 |
| SK-BR-3 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1108 | 239 | | 5108 | 12529 | 286.7 | 70.87 | 214.74 | 352.40 | 171 | 236 | 266 | 284 | 299 | 315 | 328 | 344 | 365 | 0.0797 | 998 | 0.558 | 111.13 | 15.52 | 4 | 0.0484 | 247 | 0.0020 | 16.33 | 6.555 | 0.2615 | 87243.0 | 27600000 | 9000000000 | 3000000000000 | 0.3894 | 0.2353 | 0.0003 | 0.0000 | 0.0013 | 0.0000 | 0.0025 | 0.0004 | 0.0143 | 0.0011 | 0.0584 | 0.0180 | 0.0901 | 0.0332 | 0.0841 | 0.0276 | 0.1336 | 0.0427 | 0.6155 | 0.8769 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0005 | 0.0007 | 0.0180 | 0.0141 | 0.0245 | 0.0255 | 0.0159 | 0.0137 | 0.0327 | 0.0196 | 0.9084 | 0.9264 | 0.0060 | 0.0200 | 0.0109 | 0.1000 | 0.0268 | 0.1400 | 0.0625 | 0.1500 | 0.1240 | 0.1900 | 0.1488 | 0.1800 | 0.1399 | 0.1200 | 0.1290 | 0.0700 | 0.3522 | 0.0300 | 0.0013 | 0.0007 | 0.0040 | 0.0131 | 0.0368 | 0.0646 | 0.0703 | 0.1078 | 0.7014 | 8 | 10 | 13 | 17 | 22 | 32 | 138 | 460 | 810 | 0.1100 | 11.85 | 3.914 | 0.5579 | 170291.0 | 167000000 | 181000000000 | 211000000000000 | 0.5996 | 0.0926 | 0.0347 | 0.0084 | 0.1262 | 0.0139 | 0.2429 | 0.0446 | 0.1767 | 0.0990 | 0.2019 | 0.1660 | 0.1703 | 0.2106 | 0.0315 | 0.1381 | 0.0126 | 0.1367 | 0.0032 | 0.1827 | 0.0006 | 0.0000 | 0.0006 | 0.0000 | 0.0014 | 0.0003 | 0.0037 | 0.0024 | 0.0292 | 0.0286 | 0.0404 | 0.0329 | 0.0388 | 0.0347 | 0.0584 | 0.0583 | 0.8270 | 0.8428 | 0.0000 | 0.0006 | 0.0000 | 0.0010 | 0.0012 | 0.0003 | 0.0040 | 0.0055 | 0.0339 | 0.0372 | 0.0456 | 0.0486 | 0.0395 | 0.0466 | 0.0688 | 0.0696 | 0.8070 | 0.7905 | 0.0000 | 0.0000 | 0.0006 | 0.0038 | 0.0337 | 0.0391 | 0.0399 | 0.0609 | 0.8219 |
| MCF7 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 621 | 832 | | 10045 | 16653 | 624.4 | 136.14 | 146.38 | 247.89 | 478 | 513 | 544 | 571 | 595 | 625 | 662 | 712 | 830 | 0.0671 | 1118 | 1.208 | 132.46 | 56.89 | 1 | 0.0353 | 355 | 0.0011 | 29.04 | 7.171 | 0.2381 | 408412.0 | 281000000 | 204000000000 | 157000000000000 | 0.4086 | 0.2413 | 0.0006 | 0.0000 | 0.0012 | 0.0000 | 0.0023 | 0.0007 | 0.0125 | 0.0016 | 0.0328 | 0.0154 | 0.0584 | 0.0291 | 0.0670 | 0.0221 | 0.0956 | 0.0345 | 0.7297 | 0.8966 | 0.0005 | 0.0000 | 0.0006 | 0.0000 | 0.0014 | 0.0000 | 0.0072 | 0.0002 | 0.0161 | 0.0088 | 0.0293 | 0.0152 | 0.0349 | 0.0084 | 0.0505 | 0.0148 | 0.8595 | 0.9526 | 0.0006 | 0.0029 | 0.0069 | 0.0073 | 0.0075 | 0.0190 | 0.0162 | 0.0321 | 0.0643 | 0.1226 | 0.0899 | 0.1431 | 0.0762 | 0.1080 | 0.1043 | 0.1328 | 0.6340 | 0.4321 | 0.0025 | 0.0025 | 0.0069 | 0.0195 | 0.0468 | 0.0683 | 0.0678 | 0.0849 | 0.7009 | 4 | 5 | 6 | 8 | 10 | 19 | 116 | 297 | 537 | 0.1488 | 72.06 | 4.406 | 0.5290 | 82870.7 | 61800000 | 54900000000 | 56100000000000 | 0.4135 | 0.2138 | 0.0751 | 0.0057 | 0.2521 | 0.0378 | 0.2654 | 0.1946 | 0.1669 | 0.1626 | 0.1135 | 0.1847 | 0.0785 | 0.1782 | 0.0234 | 0.1043 | 0.0200 | 0.0796 | 0.0050 | 0.0525 | 0.0000 | 0.0004 | 0.0008 | 0.0011 | 0.0014 | 0.0009 | 0.0050 | 0.0058 | 0.0321 | 0.0227 | 0.0675 | 0.0676 | 0.0431 | 0.0353 | 0.0673 | 0.0584 | 0.7827 | 0.8076 | 0.0009 | 0.0002 | 0.0005 | 0.0005 | 0.0023 | 0.0017 | 0.0068 | 0.0076 | 0.0390 | 0.0463 | 0.0847 | 0.0926 | 0.0513 | 0.0638 | 0.0884 | 0.0938 | 0.7262 | 0.6935 | 0.0000 | 0.0006 | 0.0023 | 0.0088 | 0.0301 | 0.0818 | 0.0496 | 0.0716 | 0.7552 | ||
| MCF7 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 1052 | 727 | | 435 | 10158 | 216.6 | 37.95 | 134.54 | 228.49 | 169 | 184 | 193 | 205 | 215 | 223 | 235 | 249 | 268 | 0.0475 | 483 | 1.039 | 156.49 | 50.48 | 1 | 0.9218 | 401 | 0.0052 | 14.90 | 5.415 | 0.3014 | 48369.5 | 11100000 | 2630000000 | 636000000000 | 0.4349 | 0.2080 | 0.0000 | 0.0000 | 0.0096 | 0.0000 | 0.0096 | 0.0000 | 0.0382 | 0.0047 | 0.1019 | 0.0606 | 0.1656 | 0.0629 | 0.1624 | 0.0606 | 0.1943 | 0.0956 | 0.3185 | 0.7156 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0186 | 0.0023 | 0.0849 | 0.0621 | 0.1088 | 0.0552 | 0.0928 | 0.0437 | 0.1432 | 0.0759 | 0.5517 | 0.7609 | 0.0000 | 0.1667 | 0.0000 | 0.0000 | 0.0635 | 0.1667 | 0.1905 | 0.3333 | 0.1429 | 0.3333 | 0.2540 | 0.0000 | 0.1270 | 0.0000 | 0.0635 | 0.0000 | 0.1587 | 0.0000 | 0.0000 | 0.0095 | 0.0237 | 0.0616 | 0.1754 | 0.1469 | 0.1280 | 0.1801 | 0.2749 | 5 | 7 | 8 | 9 | 11 | 16 | 98 | 264 | 495 | 0.1308 | 20.25 | 3.815 | 0.5357 | 70302.5 | 49000000 | 40900000000 | 40000000000000 | 0.5326 | 0.1283 | 0.0600 | 0.0028 | 0.2086 | 0.0308 | 0.2229 | 0.1413 | 0.2086 | 0.1636 | 0.1400 | 0.2070 | 0.0686 | 0.1930 | 0.0514 | 0.1035 | 0.0371 | 0.0867 | 0.0029 | 0.0713 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0037 | 0.0047 | 0.0269 | 0.0233 | 0.0561 | 0.0472 | 0.0326 | 0.0315 | 0.0668 | 0.0585 | 0.8136 | 0.8348 | 0.0000 | 0.0000 | 0.0004 | 0.0004 | 0.0011 | 0.0020 | 0.0049 | 0.0053 | 0.0377 | 0.0422 | 0.0681 | 0.0763 | 0.0518 | 0.0666 | 0.0883 | 0.0849 | 0.7477 | 0.7223 | 0.0000 | 0.0000 | 0.0011 | 0.0029 | 0.0350 | 0.0622 | 0.0404 | 0.0733 | 0.7851 |
| MCF7 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 867 | 303 | | 10525 | 22981 | 333.0 | 84.66 | 45.37 | 75.81 | 231 | 262 | 284 | 304 | 324 | 345 | 370 | 402 | 446 | 0.0579 | 1331 | 1.194 | 105.93 | 40.01 | 1 | 0.0257 | 270 | 0.0010 | 40.07 | 7.236 | 0.1890 | 118076.0 | 44400000 | 17700000000 | 7450000000000 | 0.4260 | 0.2189 | 0.0000 | 0.0001 | 0.0015 | 0.0003 | 0.0068 | 0.0012 | 0.0239 | 0.0034 | 0.0753 | 0.0228 | 0.1568 | 0.0533 | 0.1354 | 0.0528 | 0.1654 | 0.0744 | 0.4350 | 0.7917 | 0.0000 | 0.0000 | 0.0006 | 0.0003 | 0.0019 | 0.0008 | 0.0075 | 0.0014 | 0.0295 | 0.0128 | 0.0677 | 0.0308 | 0.0526 | 0.0219 | 0.0734 | 0.0339 | 0.7667 | 0.8981 | 0.0023 | 0.0026 | 0.0037 | 0.0052 | 0.0130 | 0.0324 | 0.0570 | 0.0999 | 0.1178 | 0.1829 | 0.1817 | 0.1971 | 0.1201 | 0.1180 | 0.1266 | 0.1621 | 0.3778 | 0.1997 | 0.0010 | 0.0017 | 0.0075 | 0.0252 | 0.0647 | 0.1221 | 0.0967 | 0.1131 | 0.5681 | 4 | 6 | 7 | 8 | 9 | 11 | 28 | 73 | 154 | 0.2117 | 3.47 | 3.149 | 0.6748 | 7805.6 | 1970000 | 596000000 | 207000000000 | 0.5167 | 0.1279 | 0.0456 | 0.0020 | 0.1917 | 0.0224 | 0.2767 | 0.1079 | 0.1710 | 0.1649 | 0.1078 | 0.1863 | 0.0870 | 0.1802 | 0.0508 | 0.1247 | 0.0497 | 0.0982 | 0.0197 | 0.1135 | 0.0000 | 0.0000 | 0.0006 | 0.0011 | 0.0017 | 0.0017 | 0.0086 | 0.0095 | 0.0396 | 0.0289 | 0.0677 | 0.0646 | 0.0470 | 0.0441 | 0.0664 | 0.0586 | 0.7684 | 0.7915 | 0.0002 | 0.0000 | 0.0004 | 0.0012 | 0.0028 | 0.0030 | 0.0103 | 0.0134 | 0.0476 | 0.0496 | 0.0803 | 0.0866 | 0.0509 | 0.0552 | 0.0806 | 0.0824 | 0.7269 | 0.7085 | 0.0000 | 0.0003 | 0.0020 | 0.0099 | 0.0440 | 0.0719 | 0.0541 | 0.0710 | 0.7467 |
| MDA-MB-231 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 154 | 245 | | 7441 | 18098 | 595.1 | 99.87 | 158.05 | 276.24 | 459 | 515 | 549 | 576 | 598 | 618 | 640 | 669 | 725 | 0.0530 | 960 | 0.791 | 112.90 | 27.89 | 2 | 0.0372 | 277 | 0.0011 | 26.39 | 7.165 | 0.2288 | 364116.0 | 229000000 | 147000000000 | 96900000000000 | 0.4475 | 0.1984 | 0.0002 | 0.0000 | 0.0007 | 0.0001 | 0.0016 | 0.0000 | 0.0053 | 0.0005 | 0.0258 | 0.0124 | 0.0455 | 0.0206 | 0.0458 | 0.0151 | 0.0692 | 0.0230 | 0.8059 | 0.9282 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0020 | 0.0003 | 0.0163 | 0.0116 | 0.0267 | 0.0174 | 0.0252 | 0.0115 | 0.0358 | 0.0181 | 0.8938 | 0.9412 | 0.0093 | 0.0000 | 0.0093 | 0.0000 | 0.0093 | 0.0000 | 0.0292 | 0.0000 | 0.0560 | 0.0000 | 0.0840 | 0.0000 | 0.0793 | 0.0000 | 0.1039 | 0.0000 | 0.6196 | 0.0000 | 0.0018 | 0.0036 | 0.0094 | 0.0214 | 0.0420 | 0.0641 | 0.0646 | 0.0876 | 0.7055 | 11 | 14 | 17 | 20 | 25 | 35 | 85 | 239 | 575 | 0.1535 | 16.74 | 4.037 | 0.6476 | 101285.0 | 90600000 | 95000000000 | 112000000000000 | 0.3437 | 0.2785 | 0.0470 | 0.0020 | 0.1678 | 0.0214 | 0.1893 | 0.0935 | 0.1530 | 0.1136 | 0.1732 | 0.1877 | 0.0980 | 0.1717 | 0.0779 | 0.1236 | 0.0671 | 0.1142 | 0.0268 | 0.1723 | 0.0002 | 0.0000 | 0.0008 | 0.0002 | 0.0008 | 0.0013 | 0.0102 | 0.0086 | 0.0376 | 0.0335 | 0.0599 | 0.0539 | 0.0436 | 0.0392 | 0.0626 | 0.0588 | 0.7843 | 0.8046 | 0.0000 | 0.0003 | 0.0012 | 0.0000 | 0.0042 | 0.0040 | 0.0138 | 0.0138 | 0.0413 | 0.0458 | 0.0655 | 0.0684 | 0.0487 | 0.0468 | 0.0667 | 0.0620 | 0.7586 | 0.7589 | 0.0002 | 0.0007 | 0.0023 | 0.0114 | 0.0416 | 0.0654 | 0.0444 | 0.0633 | 0.7707 |
| BT-20 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 640 | 647 | | 6376 | 20211 | 467.1 | 97.26 | 74.59 | 104.47 | 355 | 384 | 407 | 429 | 451 | 477 | 504 | 541 | 602 | 0.0495 | 1000 | 0.965 | 107.82 | 31.58 | 1 | 0.0402 | 256 | 0.0008 | 48.43 | 7.332 | 0.1727 | 227685.0 | 116000000 | 61700000000 | 34200000000000 | 0.4323 | 0.2096 | 0.0005 | 0.0000 | 0.0005 | 0.0002 | 0.0030 | 0.0000 | 0.0118 | 0.0013 | 0.0469 | 0.0161 | 0.0999 | 0.0336 | 0.1154 | 0.0239 | 0.1501 | 0.0351 | 0.5720 | 0.8897 | 0.0004 | 0.0000 | 0.0004 | 0.0000 | 0.0017 | 0.0000 | 0.0063 | 0.0002 | 0.0211 | 0.0111 | 0.0446 | 0.0196 | 0.0504 | 0.0108 | 0.0759 | 0.0166 | 0.7993 | 0.9416 | 0.0039 | 0.0000 | 0.0068 | 0.0084 | 0.0193 | 0.0169 | 0.0501 | 0.0478 | 0.1157 | 0.1348 | 0.1533 | 0.1573 | 0.0984 | 0.1152 | 0.1215 | 0.1348 | 0.4311 | 0.3848 | 0.0004 | 0.0014 | 0.0086 | 0.0280 | 0.0714 | 0.1288 | 0.1065 | 0.1352 | 0.5197 | 7 | 8 | 9 | 11 | 16 | 39 | 83 | 140 | 227 | 0.1404 | 11.27 | 4.303 | 0.6000 | 16476.9 | 5110000 | 1900000000 | 803000000000 | 0.4799 | 0.1508 | 0.0373 | 0.0004 | 0.1664 | 0.0126 | 0.2806 | 0.0605 | 0.1730 | 0.1438 | 0.1498 | 0.2138 | 0.1068 | 0.2197 | 0.0397 | 0.1363 | 0.0281 | 0.1023 | 0.0182 | 0.1106 | 0.0003 | 0.0001 | 0.0003 | 0.0006 | 0.0006 | 0.0010 | 0.0070 | 0.0080 | 0.0388 | 0.0338 | 0.0642 | 0.0584 | 0.0456 | 0.0429 | 0.0655 | 0.0588 | 0.7778 | 0.7963 | 0.0000 | 0.0010 | 0.0005 | 0.0002 | 0.0012 | 0.0013 | 0.0093 | 0.0155 | 0.0514 | 0.0530 | 0.0784 | 0.0890 | 0.0588 | 0.0718 | 0.0916 | 0.0918 | 0.7088 | 0.6764 | 0.0000 | 0.0000 | 0.0019 | 0.0069 | 0.0418 | 0.0702 | 0.0519 | 0.0787 | 0.7487 | ||
| MDA-MB-231 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 673 | 661 | | 8356 | 21692 | 629.4 | 88.97 | 157.77 | 200.04 | 505 | 558 | 588 | 612 | 637 | 660 | 678 | 703 | 736 | 0.0423 | 917 | 1.088 | 108.30 | 37.05 | 1 | 0.0333 | 278 | 0.0009 | 30.54 | 7.337 | 0.2196 | 404042.0 | 264000000 | 175000000000 | 118000000000000 | 0.4222 | 0.2219 | 0.0003 | 0.0000 | 0.0004 | 0.0000 | 0.0007 | 0.0000 | 0.0036 | 0.0002 | 0.0168 | 0.0091 | 0.0339 | 0.0170 | 0.0309 | 0.0087 | 0.0431 | 0.0141 | 0.8703 | 0.9508 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0017 | 0.0002 | 0.0097 | 0.0091 | 0.0211 | 0.0170 | 0.0174 | 0.0087 | 0.0212 | 0.0141 | 0.9286 | 0.9508 | 0.0052 | 0.0000 | 0.0087 | 0.0000 | 0.0280 | 0.0000 | 0.0332 | 0.0000 | 0.0769 | 0.0000 | 0.1206 | 0.0000 | 0.0962 | 0.0000 | 0.1521 | 0.0000 | 0.4790 | 0.0000 | 0.0011 | 0.0031 | 0.0058 | 0.0105 | 0.0285 | 0.0524 | 0.0515 | 0.0731 | 0.7740 | 10 | 13 | 19 | 33 | 63 | 113 | 189 | 289 | 461 | 0.0633 | 29.43 | 5.277 | 0.5302 | 64906.9 | 36700000 | 24600000000 | 18400000000000 | 0.4278 | 0.2001 | 0.0270 | 0.0020 | 0.1224 | 0.0151 | 0.2282 | 0.0660 | 0.1787 | 0.1115 | 0.1483 | 0.1596 | 0.1201 | 0.2156 | 0.0684 | 0.1388 | 0.0615 | 0.1073 | 0.0454 | 0.1841 | 0.0001 | 0.0003 | 0.0002 | 0.0008 | 0.0015 | 0.0014 | 0.0077 | 0.0098 | 0.0437 | 0.0330 | 0.0678 | 0.0540 | 0.0479 | 0.0450 | 0.0793 | 0.0589 | 0.7519 | 0.7967 | 0.0005 | 0.0000 | 0.0015 | 0.0012 | 0.0026 | 0.0031 | 0.0122 | 0.0151 | 0.0611 | 0.0727 | 0.0953 | 0.1124 | 0.0662 | 0.0769 | 0.1035 | 0.1141 | 0.6570 | 0.6045 | 0.0001 | 0.0010 | 0.0024 | 0.0121 | 0.0486 | 0.0835 | 0.0554 | 0.0881 | 0.7087 |
| MCF7 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 414 | 325 | | 5437 | 7882 | 437.9 | 83.20 | 101.98 | 125.88 | 341 | 366 | 387 | 407 | 426 | 445 | 470 | 508 | 561 | 0.1009 | 795 | 1.215 | 56.61 | 22.20 | 1 | 0.0270 | 147 | 0.0013 | 34.95 | 6.913 | 0.2030 | 198637.0 | 93400000 | 45500000000 | 22900000000000 | 0.4444 | 0.2029 | 0.0000 | 0.0000 | 0.0000 | 0.0002 | 0.0008 | 0.0000 | 0.0120 | 0.0013 | 0.0499 | 0.0139 | 0.1259 | 0.0375 | 0.1288 | 0.0278 | 0.1661 | 0.0447 | 0.5165 | 0.8745 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0047 | 0.0004 | 0.0231 | 0.0107 | 0.0658 | 0.0258 | 0.0594 | 0.0103 | 0.0912 | 0.0214 | 0.7556 | 0.9315 | 0.0000 | 0.0057 | 0.0056 | 0.0230 | 0.0169 | 0.1092 | 0.0666 | 0.1782 | 0.1332 | 0.1494 | 0.1603 | 0.1839 | 0.0971 | 0.1149 | 0.1332 | 0.0977 | 0.3871 | 0.1379 | 0.0013 | 0.0051 | 0.0161 | 0.0442 | 0.0794 | 0.1219 | 0.0968 | 0.1125 | 0.5227 | 6 | 8 | 10 | 15 | 37 | 76 | 132 | 208 | 298 | 0.0817 | 10.67 | 4.715 | 0.5608 | 26243.7 | 8800000 | 3420000000 | 1480000000000 | 0.4564 | 0.1723 | 0.0249 | 0.0017 | 0.0817 | 0.0059 | 0.2664 | 0.0462 | 0.2433 | 0.0891 | 0.1456 | 0.1756 | 0.1155 | 0.2311 | 0.0639 | 0.1395 | 0.0373 | 0.1218 | 0.0213 | 0.1891 | 0.0007 | 0.0003 | 0.0007 | 0.0006 | 0.0029 | 0.0015 | 0.0098 | 0.0052 | 0.0334 | 0.0268 | 0.0579 | 0.0534 | 0.0435 | 0.0365 | 0.0648 | 0.0589 | 0.7863 | 0.8169 | 0.0008 | 0.0000 | 0.0000 | 0.0004 | 0.0016 | 0.0009 | 0.0148 | 0.0152 | 0.0409 | 0.0567 | 0.0678 | 0.0844 | 0.0650 | 0.0612 | 0.0770 | 0.0933 | 0.7319 | 0.6878 | 0.0004 | 0.0015 | 0.0025 | 0.0105 | 0.0384 | 0.0613 | 0.0537 | 0.0758 | 0.7560 | ||
| MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 461 | 123 | | 3257 | 6809 | 514.7 | 105.53 | 61.25 | 124.20 | 368 | 433 | 474 | 500 | 525 | 551 | 579 | 608 | 638 | 0.0824 | 561 | 0.766 | 87.00 | 16.03 | 3 | 0.0620 | 202 | 0.0010 | 52.75 | 7.148 | 0.1825 | 276060.0 | 153000000 | 86800000000 | 50400000000000 | 0.4286 | 0.2196 | 0.0000 | 0.0000 | 0.0014 | 0.0000 | 0.0068 | 0.0000 | 0.0140 | 0.0013 | 0.0512 | 0.0198 | 0.0978 | 0.0406 | 0.0965 | 0.0227 | 0.1277 | 0.0373 | 0.6046 | 0.8782 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0029 | 0.0013 | 0.0220 | 0.0197 | 0.0447 | 0.0384 | 0.0293 | 0.0184 | 0.0411 | 0.0288 | 0.8596 | 0.8934 | 0.0077 | 0.1333 | 0.0173 | 0.1333 | 0.0288 | 0.0667 | 0.0865 | 0.1333 | 0.1404 | 0.2667 | 0.1442 | 0.1333 | 0.1231 | 0.0000 | 0.1654 | 0.1333 | 0.2865 | 0.0000 | 0.0011 | 0.0023 | 0.0079 | 0.0186 | 0.0514 | 0.0814 | 0.0729 | 0.1040 | 0.6605 | 7 | 9 | 11 | 12 | 14 | 19 | 31 | 56 | 175 | 0.1883 | 7.43 | 3.201 | 0.7374 | 19174.6 | 10600000 | 7360000000 | 5780000000000 | 0.4921 | 0.1647 | 0.0338 | 0.0142 | 0.0549 | 0.0252 | 0.0717 | 0.0377 | 0.0928 | 0.0660 | 0.1392 | 0.0849 | 0.1814 | 0.1289 | 0.2363 | 0.1321 | 0.1097 | 0.1525 | 0.0802 | 0.3585 | 0.0034 | 0.0045 | 0.0048 | 0.0078 | 0.0034 | 0.0111 | 0.0109 | 0.0167 | 0.0212 | 0.0279 | 0.0519 | 0.0507 | 0.0355 | 0.0423 | 0.0444 | 0.0591 | 0.8245 | 0.7799 | 0.0000 | 0.0000 | 0.0008 | 0.0000 | 0.0016 | 0.0000 | 0.0073 | 0.0078 | 0.0334 | 0.0336 | 0.0465 | 0.0509 | 0.0302 | 0.0259 | 0.0522 | 0.0578 | 0.8280 | 0.8240 | 0.0008 | 0.0008 | 0.0046 | 0.0106 | 0.0236 | 0.0540 | 0.0274 | 0.0547 | 0.8237 |
| MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 740 | 703 | | 8862 | 18824 | 530.1 | 80.43 | 114.15 | 251.56 | 421 | 467 | 496 | 517 | 535 | 553 | 573 | 598 | 631 | 0.0548 | 1032 | 0.545 | 114.22 | 22.67 | 5 | 0.0372 | 330 | 0.0009 | 38.41 | 7.314 | 0.2073 | 287452.0 | 159000000 | 89500000000 | 51200000000000 | 0.4491 | 0.2025 | 0.0001 | 0.0000 | 0.0006 | 0.0000 | 0.0007 | 0.0001 | 0.0056 | 0.0007 | 0.0282 | 0.0139 | 0.0564 | 0.0200 | 0.0512 | 0.0144 | 0.0715 | 0.0211 | 0.7858 | 0.9298 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0001 | 0.0016 | 0.0007 | 0.0179 | 0.0139 | 0.0306 | 0.0200 | 0.0252 | 0.0144 | 0.0335 | 0.0202 | 0.8913 | 0.9307 | 0.0075 | 1.0000 | 0.0188 | 0.0000 | 0.0225 | 0.0000 | 0.0476 | 0.0000 | 0.1164 | 0.0000 | 0.1640 | 0.0000 | 0.1014 | 0.0000 | 0.1502 | 0.0000 | 0.3717 | 0.0000 | 0.0006 | 0.0036 | 0.0074 | 0.0181 | 0.0434 | 0.0613 | 0.0734 | 0.0863 | 0.7059 | 9 | 10 | 12 | 13 | 15 | 20 | 38 | 121 | 352 | 0.1429 | 9.00 | 3.049 | 0.5952 | 76308.2 | 79500000 | 99600000000 | 139000000000000 | 0.5235 | 0.1294 | 0.0259 | 0.0023 | 0.0761 | 0.0164 | 0.2120 | 0.0561 | 0.1942 | 0.0865 | 0.2006 | 0.1645 | 0.1003 | 0.2050 | 0.1036 | 0.1458 | 0.0631 | 0.1341 | 0.0243 | 0.1894 | 0.0000 | 0.0004 | 0.0002 | 0.0004 | 0.0012 | 0.0011 | 0.0067 | 0.0072 | 0.0396 | 0.0383 | 0.0538 | 0.0475 | 0.0401 | 0.0385 | 0.0569 | 0.0591 | 0.8015 | 0.8073 | 0.0003 | 0.0000 | 0.0006 | 0.0006 | 0.0017 | 0.0021 | 0.0056 | 0.0079 | 0.0476 | 0.0539 | 0.0673 | 0.0667 | 0.0437 | 0.0521 | 0.0707 | 0.0758 | 0.7625 | 0.7409 | 0.0000 | 0.0005 | 0.0016 | 0.0065 | 0.0428 | 0.0586 | 0.0418 | 0.0664 | 0.7819 |
| MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1191 | 273 | | 5225 | 11025 | 340.7 | 62.23 | 307.66 | 490.68 | 248 | 283 | 309 | 330 | 349 | 367 | 381 | 396 | 416 | 0.0786 | 867 | 0.925 | 79.06 | 24.04 | 4 | 0.0404 | 211 | 0.0014 | 23.53 | 6.846 | 0.2524 | 119949.0 | 43400000 | 16100000000 | 6080000000000 | 0.4363 | 0.2015 | 0.0005 | 0.0000 | 0.0024 | 0.0000 | 0.0052 | 0.0004 | 0.0144 | 0.0012 | 0.0415 | 0.0155 | 0.0735 | 0.0306 | 0.0749 | 0.0196 | 0.1045 | 0.0333 | 0.6830 | 0.8994 | 0.0002 | 0.0000 | 0.0009 | 0.0000 | 0.0014 | 0.0004 | 0.0046 | 0.0012 | 0.0191 | 0.0153 | 0.0353 | 0.0304 | 0.0290 | 0.0163 | 0.0376 | 0.0273 | 0.8719 | 0.9093 | 0.0076 | 0.0000 | 0.0291 | 1.0000 | 0.0443 | 0.0000 | 0.0581 | 0.0000 | 0.1407 | 0.0000 | 0.1361 | 0.0000 | 0.1300 | 0.0000 | 0.1529 | 0.0000 | 0.3012 | 0.0000 | 0.0007 | 0.0021 | 0.0070 | 0.0115 | 0.0369 | 0.0518 | 0.0539 | 0.0869 | 0.7493 | 8 | 10 | 12 | 16 | 25 | 61 | 277 | 673 | 1103 | 0.0635 | 24.60 | 4.331 | 0.4441 | 335399.0 | 461000000 | 722000000000 | 1.24E+15 | 0.5061 | 0.1164 | 0.0746 | 0.0000 | 0.2293 | 0.0218 | 0.2541 | 0.1592 | 0.1602 | 0.1687 | 0.1409 | 0.2082 | 0.0829 | 0.1891 | 0.0304 | 0.0898 | 0.0193 | 0.0939 | 0.0083 | 0.0694 | 0.0000 | 0.0000 | 0.0006 | 0.0006 | 0.0038 | 0.0011 | 0.0065 | 0.0047 | 0.0332 | 0.0356 | 0.0632 | 0.0601 | 0.0397 | 0.0361 | 0.0585 | 0.0593 | 0.7947 | 0.8025 | 0.0003 | 0.0003 | 0.0007 | 0.0003 | 0.0023 | 0.0017 | 0.0056 | 0.0055 | 0.0391 | 0.0464 | 0.0687 | 0.0695 | 0.0444 | 0.0488 | 0.0736 | 0.0768 | 0.7653 | 0.7506 | 0.0003 | 0.0012 | 0.0016 | 0.0068 | 0.0346 | 0.0626 | 0.0392 | 0.0688 | 0.7849 |
| MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1140 | 503 | | 4025 | 13483 | 436.8 | 85.79 | 132.10 | 242.48 | 338 | 368 | 391 | 415 | 440 | 463 | 488 | 513 | 540 | 0.0518 | 698 | 1.105 | 49.03 | 18.38 | 2 | 0.0330 | 133 | 0.0012 | 33.18 | 6.972 | 0.2087 | 198109.0 | 92600000 | 44400000000 | 21800000000000 | 0.4526 | 0.1884 | 0.0007 | 0.0000 | 0.0014 | 0.0000 | 0.0035 | 0.0000 | 0.0139 | 0.0010 | 0.0522 | 0.0198 | 0.1099 | 0.0311 | 0.0967 | 0.0257 | 0.1398 | 0.0363 | 0.5819 | 0.8861 | 0.0006 | 0.0000 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0037 | 0.0005 | 0.0267 | 0.0189 | 0.0517 | 0.0288 | 0.0402 | 0.0186 | 0.0577 | 0.0283 | 0.8190 | 0.9049 | 0.0050 | 0.0000 | 0.0033 | 0.0606 | 0.0429 | 0.1515 | 0.0759 | 0.2121 | 0.1188 | 0.1212 | 0.1914 | 0.2424 | 0.1452 | 0.1515 | 0.1551 | 0.0303 | 0.2624 | 0.0303 | 0.0005 | 0.0024 | 0.0058 | 0.0169 | 0.0551 | 0.0851 | 0.0807 | 0.1054 | 0.6481 | 6 | 7 | 9 | 10 | 14 | 25 | 74 | 196 | 483 | 0.1545 | 27.57 | 4.157 | 0.6237 | 76242.5 | 60100000 | 54300000000 | 53300000000000 | 0.5764 | 0.1021 | 0.0301 | 0.0017 | 0.1284 | 0.0108 | 0.1997 | 0.0687 | 0.1458 | 0.1026 | 0.1838 | 0.1745 | 0.1331 | 0.1977 | 0.0666 | 0.1266 | 0.0602 | 0.1290 | 0.0523 | 0.1886 | 0.0003 | 0.0000 | 0.0005 | 0.0008 | 0.0025 | 0.0013 | 0.0066 | 0.0078 | 0.0442 | 0.0373 | 0.0700 | 0.0607 | 0.0437 | 0.0396 | 0.0626 | 0.0595 | 0.7696 | 0.7931 | 0.0000 | 0.0014 | 0.0013 | 0.0014 | 0.0027 | 0.0036 | 0.0166 | 0.0159 | 0.0525 | 0.0587 | 0.0807 | 0.0844 | 0.0558 | 0.0543 | 0.0751 | 0.0736 | 0.7153 | 0.7065 | 0.0003 | 0.0012 | 0.0033 | 0.0100 | 0.0504 | 0.0697 | 0.0573 | 0.0733 | 0.7346 |
| MDA-MB-231 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 200 | 513 | | 11296 | 11224 | 660.4 | 94.02 | 95.02 | 136.71 | 543 | 587 | 617 | 640 | 661 | 683 | 708 | 735 | 774 | 0.1009 | 1133 | 0.918 | 133.74 | 44.91 | 2 | 0.0313 | 353 | 0.0006 | 79.90 | 7.739 | 0.1635 | 444990.0 | 305000000 | 213000000000 | 152000000000000 | 0.4251 | 0.2228 | 0.0000 | 0.0000 | 0.0005 | 0.0000 | 0.0017 | 0.0000 | 0.0042 | 0.0006 | 0.0187 | 0.0081 | 0.0399 | 0.0182 | 0.0436 | 0.0113 | 0.0656 | 0.0181 | 0.8257 | 0.9436 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0006 | 0.0000 | 0.0022 | 0.0004 | 0.0107 | 0.0077 | 0.0240 | 0.0167 | 0.0219 | 0.0084 | 0.0314 | 0.0139 | 0.9090 | 0.9530 | 0.0074 | 0.0816 | 0.0173 | 0.0204 | 0.0222 | 0.0408 | 0.0937 | 0.2245 | 0.0912 | 0.2245 | 0.1307 | 0.2041 | 0.1097 | 0.0816 | 0.1233 | 0.1224 | 0.4044 | 0.0000 | 0.0016 | 0.0026 | 0.0092 | 0.0209 | 0.0527 | 0.0772 | 0.0800 | 0.1071 | 0.6486 | 12 | 16 | 20 | 27 | 38 | 53 | 81 | 138 | 272 | 0.0564 | 8.94 | 4.344 | 0.6275 | 27717.6 | 13300000 | 8080000000 | 5720000000000 | 0.4886 | 0.1747 | 0.0110 | 0.0020 | 0.0386 | 0.0109 | 0.0684 | 0.0288 | 0.1323 | 0.0387 | 0.2183 | 0.1107 | 0.1940 | 0.1846 | 0.1147 | 0.1166 | 0.1422 | 0.1509 | 0.0805 | 0.3568 | 0.0009 | 0.0007 | 0.0031 | 0.0037 | 0.0037 | 0.0072 | 0.0119 | 0.0120 | 0.0417 | 0.0400 | 0.0716 | 0.0744 | 0.0409 | 0.0423 | 0.0707 | 0.0596 | 0.7555 | 0.7601 | 0.0008 | 0.0004 | 0.0011 | 0.0022 | 0.0042 | 0.0043 | 0.0168 | 0.0173 | 0.0348 | 0.0381 | 0.0880 | 0.0934 | 0.0513 | 0.0510 | 0.0677 | 0.0636 | 0.7353 | 0.7297 | 0.0007 | 0.0010 | 0.0036 | 0.0116 | 0.0416 | 0.0819 | 0.0459 | 0.0714 | 0.7423 |
| MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 584 | 956 | | 603 | 2463 | 406.2 | 49.35 | 106.45 | 171.74 | 341 | 360 | 374 | 391 | 405 | 421 | 434 | 449 | 475 | 0.1397 | 344 | 0.741 | 102.83 | 29.41 | 1 | 0.4809 | 290 | 0.0035 | 18.91 | 5.793 | 0.2498 | 167409.0 | 70000000 | 29700000000 | 12800000000000 | 0.3625 | 0.2807 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0037 | 0.0000 | 0.0037 | 0.0017 | 0.0608 | 0.0415 | 0.0958 | 0.0630 | 0.0608 | 0.0315 | 0.1105 | 0.0481 | 0.6648 | 0.8143 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0017 | 0.0000 | 0.0034 | 0.0017 | 0.0444 | 0.0415 | 0.0650 | 0.0630 | 0.0342 | 0.0315 | 0.0581 | 0.0481 | 0.7932 | 0.8143 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0952 | 0.0000 | 0.1190 | 0.0000 | 0.1905 | 0.0000 | 0.2381 | 0.0000 | 0.1429 | 0.0000 | 0.1190 | 0.0000 | 0.0952 | 0.0000 | 0.0000 | 0.0000 | 0.0101 | 0.0269 | 0.0842 | 0.1010 | 0.1010 | 0.1279 | 0.5488 | 8 | 10 | 11 | 13 | 15 | 30 | 107 | 188 | 310 | 0.1805 | 23.87 | 3.814 | 0.6487 | 40814.5 | 22400000 | 14400000000 | 10100000000000 | 0.5211 | 0.1245 | 0.0866 | 0.0122 | 0.0551 | 0.0528 | 0.1417 | 0.1098 | 0.2205 | 0.1138 | 0.1575 | 0.1301 | 0.1890 | 0.1707 | 0.0787 | 0.1220 | 0.0236 | 0.1260 | 0.0472 | 0.1626 | 0.0012 | 0.0000 | 0.0000 | 0.0047 | 0.0025 | 0.0070 | 0.0149 | 0.0117 | 0.0532 | 0.0493 | 0.0916 | 0.0880 | 0.0668 | 0.0563 | 0.0693 | 0.0599 | 0.7005 | 0.7230 | 0.0015 | 0.0017 | 0.0000 | 0.0033 | 0.0132 | 0.0132 | 0.0264 | 0.0281 | 0.0543 | 0.0677 | 0.1189 | 0.1254 | 0.0764 | 0.0858 | 0.0837 | 0.1073 | 0.6256 | 0.5677 | 0.0000 | 0.0013 | 0.0040 | 0.0148 | 0.0617 | 0.1074 | 0.0671 | 0.0832 | 0.6604 |
| MCF7 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 517 | 209 | | 10942 | 35449 | 447.3 | 110.82 | 142.08 | 205.96 | 312 | 350 | 381 | 410 | 439 | 469 | 501 | 538 | 598 | 0.0363 | 1286 | 0.903 | 94.01 | 21.02 | 3 | 0.0206 | 225 | 0.0006 | 67.31 | 7.714 | 0.1503 | 212393.0 | 107000000 | 56200000000 | 31100000000000 | 0.4346 | 0.2214 | 0.0002 | 0.0000 | 0.0011 | 0.0000 | 0.0049 | 0.0003 | 0.0220 | 0.0020 | 0.0807 | 0.0222 | 0.1586 | 0.0494 | 0.1521 | 0.0568 | 0.1699 | 0.0831 | 0.4104 | 0.7861 | 0.0001 | 0.0000 | 0.0005 | 0.0000 | 0.0011 | 0.0001 | 0.0069 | 0.0010 | 0.0331 | 0.0142 | 0.0664 | 0.0263 | 0.0584 | 0.0248 | 0.0766 | 0.0387 | 0.7570 | 0.8948 | 0.0022 | 0.0069 | 0.0081 | 0.0139 | 0.0103 | 0.0416 | 0.0550 | 0.1150 | 0.1279 | 0.1967 | 0.1699 | 0.1884 | 0.1225 | 0.1177 | 0.1516 | 0.1399 | 0.3524 | 0.1801 | 0.0008 | 0.0008 | 0.0065 | 0.0223 | 0.0687 | 0.1106 | 0.0929 | 0.1244 | 0.5730 | 7 | 10 | 12 | 15 | 24 | 71 | 163 | 276 | 443 | 0.1042 | 31.77 | 4.906 | 0.5483 | 62607.4 | 38100000 | 28100000000 | 23900000000000 | 0.4712 | 0.1726 | 0.0362 | 0.0022 | 0.1614 | 0.0112 | 0.2304 | 0.0744 | 0.1585 | 0.1487 | 0.1473 | 0.1922 | 0.1121 | 0.1786 | 0.0662 | 0.1198 | 0.0498 | 0.1135 | 0.0382 | 0.1594 | 0.0002 | 0.0001 | 0.0002 | 0.0002 | 0.0007 | 0.0005 | 0.0067 | 0.0061 | 0.0345 | 0.0311 | 0.0658 | 0.0530 | 0.0462 | 0.0389 | 0.0718 | 0.0600 | 0.7738 | 0.8102 | 0.0000 | 0.0005 | 0.0006 | 0.0007 | 0.0010 | 0.0021 | 0.0102 | 0.0107 | 0.0492 | 0.0560 | 0.0855 | 0.0946 | 0.0637 | 0.0738 | 0.0966 | 0.1019 | 0.6933 | 0.6595 | 0.0002 | 0.0003 | 0.0018 | 0.0074 | 0.0431 | 0.0740 | 0.0560 | 0.0876 | 0.7297 |
| SK-BR-3 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 913 | 210 | | 8143 | 27204 | 304.1 | 75.81 | 255.15 | 302.47 | 195 | 245 | 273 | 292 | 310 | 328 | 348 | 371 | 396 | 0.0396 | 1076 | 1.114 | 110.82 | 43.01 | 5 | 0.0373 | 304 | 0.0010 | 29.98 | 7.166 | 0.2157 | 98209.8 | 33200000 | 11600000000 | 4170000000000 | 0.4037 | 0.2325 | 0.0006 | 0.0000 | 0.0017 | 0.0000 | 0.0087 | 0.0001 | 0.0205 | 0.0021 | 0.0499 | 0.0164 | 0.0838 | 0.0287 | 0.0889 | 0.0302 | 0.1235 | 0.0508 | 0.6224 | 0.8717 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0011 | 0.0000 | 0.0037 | 0.0011 | 0.0125 | 0.0105 | 0.0220 | 0.0168 | 0.0235 | 0.0118 | 0.0341 | 0.0168 | 0.9030 | 0.9431 | 0.0027 | 0.0366 | 0.0038 | 0.0549 | 0.0215 | 0.0623 | 0.0447 | 0.1282 | 0.0910 | 0.2051 | 0.1319 | 0.1722 | 0.1179 | 0.1612 | 0.1524 | 0.0989 | 0.4340 | 0.0806 | 0.0014 | 0.0032 | 0.0069 | 0.0123 | 0.0407 | 0.0638 | 0.0782 | 0.0981 | 0.6954 | 11 | 17 | 29 | 55 | 110 | 207 | 346 | 511 | 718 | 0.0322 | 37.90 | 6.066 | 0.4425 | 156585.0 | 127000000 | 124000000000 | 141000000000000 | 0.4560 | 0.1894 | 0.0158 | 0.0005 | 0.0981 | 0.0072 | 0.2220 | 0.0341 | 0.1823 | 0.1004 | 0.1923 | 0.1873 | 0.1306 | 0.2205 | 0.0775 | 0.1404 | 0.0464 | 0.1380 | 0.0349 | 0.1716 | 0.0002 | 0.0001 | 0.0006 | 0.0008 | 0.0034 | 0.0020 | 0.0077 | 0.0080 | 0.0389 | 0.0364 | 0.0615 | 0.0565 | 0.0439 | 0.0435 | 0.0653 | 0.0602 | 0.7784 | 0.7924 | 0.0005 | 0.0004 | 0.0011 | 0.0013 | 0.0019 | 0.0025 | 0.0109 | 0.0122 | 0.0412 | 0.0488 | 0.0778 | 0.0819 | 0.0567 | 0.0645 | 0.0835 | 0.0869 | 0.7263 | 0.7017 | 0.0003 | 0.0012 | 0.0026 | 0.0088 | 0.0373 | 0.0681 | 0.0507 | 0.0713 | 0.7596 |
| MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 318 | 624 | | 6835 | 14487 | 545.4 | 80.10 | 171.75 | 314.77 | 430 | 485 | 516 | 537 | 554 | 568 | 585 | 605 | 635 | 0.0583 | 845 | 0.559 | 146.51 | 30.07 | 3 | 0.0660 | 451 | 0.0011 | 31.34 | 7.160 | 0.2167 | 303826.0 | 173000000 | 99800000000 | 58700000000000 | 0.4423 | 0.2040 | 0.0002 | 0.0000 | 0.0000 | 0.0000 | 0.0012 | 0.0000 | 0.0046 | 0.0007 | 0.0219 | 0.0105 | 0.0376 | 0.0227 | 0.0393 | 0.0121 | 0.0589 | 0.0224 | 0.8363 | 0.9315 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0021 | 0.0006 | 0.0138 | 0.0100 | 0.0230 | 0.0208 | 0.0226 | 0.0098 | 0.0272 | 0.0183 | 0.9111 | 0.9405 | 0.0093 | 0.0000 | 0.0163 | 0.0000 | 0.0280 | 0.0000 | 0.0676 | 0.0000 | 0.1189 | 0.0000 | 0.1352 | 0.0000 | 0.1119 | 0.0000 | 0.1119 | 0.0000 | 0.4009 | 0.0000 | 0.0008 | 0.0005 | 0.0050 | 0.0188 | 0.0379 | 0.0636 | 0.0767 | 0.0981 | 0.6986 | 11 | 13 | 15 | 19 | 25 | 47 | 102 | 252 | 575 | 0.1437 | 10.43 | 3.781 | 0.6289 | 128574.0 | 142000000 | 187000000000 | 273000000000000 | 0.3937 | 0.2546 | 0.0244 | 0.0022 | 0.0822 | 0.0126 | 0.1735 | 0.0445 | 0.1903 | 0.0867 | 0.2116 | 0.1890 | 0.1248 | 0.1883 | 0.0868 | 0.1401 | 0.0715 | 0.1371 | 0.0350 | 0.1994 | 0.0000 | 0.0005 | 0.0010 | 0.0007 | 0.0036 | 0.0030 | 0.0067 | 0.0079 | 0.0359 | 0.0345 | 0.0508 | 0.0483 | 0.0398 | 0.0391 | 0.0646 | 0.0606 | 0.7976 | 0.8055 | 0.0009 | 0.0007 | 0.0009 | 0.0010 | 0.0028 | 0.0020 | 0.0080 | 0.0081 | 0.0423 | 0.0430 | 0.0537 | 0.0696 | 0.0515 | 0.0545 | 0.0771 | 0.0794 | 0.7628 | 0.7418 | 0.0006 | 0.0014 | 0.0023 | 0.0093 | 0.0369 | 0.0544 | 0.0417 | 0.0668 | 0.7866 |
| BT-20 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 718 | 209 | | 6919 | 20153 | 439.9 | 83.94 | 59.12 | 60.79 | 328 | 364 | 393 | 418 | 442 | 465 | 486 | 511 | 544 | 0.0555 | 1118 | 1.097 | 116.93 | 36.89 | 1 | 0.0405 | 280 | 0.0010 | 31.34 | 7.121 | 0.1942 | 200514.0 | 94500000 | 45900000000 | 23000000000000 | 0.3868 | 0.2525 | 0.0002 | 0.0000 | 0.0002 | 0.0000 | 0.0021 | 0.0000 | 0.0112 | 0.0015 | 0.0437 | 0.0118 | 0.0766 | 0.0244 | 0.0951 | 0.0209 | 0.1280 | 0.0268 | 0.6427 | 0.9146 | 0.0002 | 0.0000 | 0.0002 | 0.0000 | 0.0005 | 0.0000 | 0.0040 | 0.0013 | 0.0171 | 0.0100 | 0.0281 | 0.0194 | 0.0344 | 0.0128 | 0.0426 | 0.0172 | 0.8730 | 0.9393 | 0.0040 | 0.0086 | 0.0081 | 0.0000 | 0.0424 | 0.0259 | 0.0727 | 0.2586 | 0.1354 | 0.0862 | 0.1687 | 0.1810 | 0.1343 | 0.1293 | 0.1384 | 0.0431 | 0.2960 | 0.2672 | 0.0003 | 0.0014 | 0.0020 | 0.0108 | 0.0519 | 0.0935 | 0.0896 | 0.1278 | 0.6227 | 8 | 10 | 14 | 25 | 40 | 57 | 76 | 99 | 135 | 0.0457 | 4.18 | 4.483 | 0.5799 | 7190.4 | 1330000 | 338000000 | 109000000000 | 0.4299 | 0.1814 | 0.0071 | 0.0015 | 0.0560 | 0.0042 | 0.1504 | 0.0171 | 0.2041 | 0.0543 | 0.2237 | 0.1277 | 0.1653 | 0.2005 | 0.1077 | 0.1668 | 0.0611 | 0.1704 | 0.0247 | 0.2575 | 0.0002 | 0.0001 | 0.0009 | 0.0008 | 0.0023 | 0.0018 | 0.0122 | 0.0087 | 0.0364 | 0.0271 | 0.0609 | 0.0475 | 0.0552 | 0.0389 | 0.0755 | 0.0611 | 0.7565 | 0.8141 | 0.0011 | 0.0011 | 0.0026 | 0.0037 | 0.0041 | 0.0073 | 0.0192 | 0.0257 | 0.0575 | 0.0690 | 0.0847 | 0.1021 | 0.0802 | 0.0802 | 0.1038 | 0.1182 | 0.6468 | 0.5927 | 0.0005 | 0.0010 | 0.0038 | 0.0132 | 0.0444 | 0.0754 | 0.0604 | 0.0891 | 0.7123 | ||
| MCF 10A | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 797 | 276 | | 3081 | 14857 | 257.1 | 73.60 | 95.99 | 124.19 | 175 | 187 | 202 | 218 | 241 | 266 | 296 | 325 | 367 | 0.0703 | 1045 | 0.709 | 60.54 | 16.03 | 2 | 0.0568 | 175 | 0.0097 | 3.01 | 5.047 | 0.5308 | 71538.3 | 21500000 | 6880000000 | 2330000000000 | 0.3683 | 0.2682 | 0.0023 | 0.0000 | 0.0053 | 0.0000 | 0.0107 | 0.0015 | 0.0328 | 0.0041 | 0.0710 | 0.0354 | 0.1154 | 0.0479 | 0.1054 | 0.0420 | 0.1398 | 0.0593 | 0.5172 | 0.8099 | 0.0014 | 0.0000 | 0.0019 | 0.0000 | 0.0043 | 0.0007 | 0.0125 | 0.0013 | 0.0288 | 0.0202 | 0.0389 | 0.0276 | 0.0408 | 0.0189 | 0.0504 | 0.0315 | 0.8209 | 0.8998 | 0.0013 | 0.0000 | 0.0000 | 0.0111 | 0.0090 | 0.0028 | 0.0168 | 0.0306 | 0.0530 | 0.0889 | 0.0917 | 0.1306 | 0.0646 | 0.1139 | 0.0904 | 0.1500 | 0.6731 | 0.4722 | 0.0015 | 0.0015 | 0.0052 | 0.0126 | 0.0238 | 0.0535 | 0.0416 | 0.0558 | 0.8045 | 12 | 19 | 29 | 42 | 54 | 70 | 95 | 135 | 230 | 0.0663 | 4.54 | 3.869 | 0.7237 | 24635.6 | 11400000 | 7270000000 | 5520000000000 | 0.4425 | 0.1810 | 0.0092 | 0.0039 | 0.0252 | 0.0102 | 0.0406 | 0.0158 | 0.0729 | 0.0304 | 0.1237 | 0.0621 | 0.1566 | 0.0900 | 0.1494 | 0.0954 | 0.1869 | 0.1280 | 0.2356 | 0.5641 | 0.0025 | 0.0017 | 0.0033 | 0.0049 | 0.0040 | 0.0052 | 0.0113 | 0.0100 | 0.0302 | 0.0240 | 0.0458 | 0.0344 | 0.0473 | 0.0408 | 0.0691 | 0.0611 | 0.7864 | 0.8179 | 0.0008 | 0.0007 | 0.0034 | 0.0027 | 0.0059 | 0.0050 | 0.0163 | 0.0174 | 0.0487 | 0.0557 | 0.0704 | 0.0795 | 0.0637 | 0.0651 | 0.0789 | 0.0849 | 0.7118 | 0.6890 | 0.0011 | 0.0052 | 0.0059 | 0.0142 | 0.0363 | 0.0542 | 0.0582 | 0.0716 | 0.7533 |
| BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1215 | 337 | | 5299 | 15208 | 314.6 | 49.18 | 289.78 | 445.68 | 258 | 273 | 285 | 295 | 306 | 318 | 334 | 356 | 383 | 0.0592 | 900 | 0.916 | 116.83 | 42.76 | 1 | 0.0670 | 355 | 0.0017 | 23.16 | 6.655 | 0.2317 | 101403.0 | 33500000 | 11400000000 | 3950000000000 | 0.3986 | 0.2511 | 0.0000 | 0.0000 | 0.0007 | 0.0000 | 0.0023 | 0.0000 | 0.0093 | 0.0002 | 0.0305 | 0.0140 | 0.0753 | 0.0305 | 0.0827 | 0.0190 | 0.1286 | 0.0295 | 0.6705 | 0.9068 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0008 | 0.0000 | 0.0033 | 0.0000 | 0.0158 | 0.0117 | 0.0404 | 0.0247 | 0.0404 | 0.0102 | 0.0640 | 0.0160 | 0.8348 | 0.9373 | 0.0063 | 0.0000 | 0.0158 | 0.0000 | 0.0412 | 0.0000 | 0.0824 | 0.0000 | 0.1173 | 0.0000 | 0.1347 | 0.0000 | 0.1094 | 0.0000 | 0.1410 | 0.0000 | 0.3518 | 0.0000 | 0.0022 | 0.0083 | 0.0188 | 0.0419 | 0.0777 | 0.1104 | 0.0877 | 0.1144 | 0.5386 | 14 | 17 | 20 | 24 | 37 | 96 | 310 | 568 | 955 | 0.0512 | 92.27 | 5.412 | 0.4889 | 282587.0 | 374000000 | 589000000000 | 1.04E+15 | 0.4260 | 0.2078 | 0.0678 | 0.0021 | 0.2554 | 0.0310 | 0.2713 | 0.1590 | 0.1515 | 0.1654 | 0.1154 | 0.1977 | 0.0736 | 0.1668 | 0.0375 | 0.0880 | 0.0202 | 0.0992 | 0.0072 | 0.0908 | 0.0000 | 0.0000 | 0.0002 | 0.0006 | 0.0006 | 0.0002 | 0.0058 | 0.0039 | 0.0392 | 0.0362 | 0.0676 | 0.0614 | 0.0464 | 0.0369 | 0.0642 | 0.0614 | 0.7760 | 0.7994 | 0.0000 | 0.0003 | 0.0000 | 0.0003 | 0.0016 | 0.0038 | 0.0107 | 0.0111 | 0.0513 | 0.0494 | 0.0801 | 0.0970 | 0.0632 | 0.0688 | 0.0880 | 0.0932 | 0.7051 | 0.6762 | 0.0000 | 0.0000 | 0.0009 | 0.0068 | 0.0458 | 0.0717 | 0.0503 | 0.0824 | 0.7421 |