High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
Download: Excel (XLSX), Comma-separated (CSV)
Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 166 | 253 | 6270 | 6263 | 146.8 | 53.83 | 210.83 | 195.38 | 91 | 105 | 116 | 126 | 136 | 148 | 163 | 183 | 214 | 0.1284 | 804 | 0.784 | 97.01 | 20.88 | 2 | 0.0364 | 228 | 0.0012 | 46.26 | 7.074 | 0.1935 | 24453.4 | 4680000 | 1040000000 | 271000000000 | 0.4725 | 0.1765 | 0.0007 | 0.0000 | 0.0042 | 0.0002 | 0.0251 | 0.0014 | 0.0639 | 0.0074 | 0.1432 | 0.0380 | 0.2040 | 0.0897 | 0.1788 | 0.0986 | 0.1596 | 0.1272 | 0.2204 | 0.6374 | 0.0005 | 0.0000 | 0.0007 | 0.0002 | 0.0037 | 0.0007 | 0.0128 | 0.0035 | 0.0536 | 0.0227 | 0.0951 | 0.0435 | 0.0820 | 0.0411 | 0.1203 | 0.0647 | 0.6313 | 0.8237 | 0.0000 | 0.0027 | 0.0028 | 0.0199 | 0.0231 | 0.0292 | 0.0651 | 0.1089 | 0.1254 | 0.1169 | 0.1779 | 0.2058 | 0.1036 | 0.0943 | 0.1359 | 0.1262 | 0.3662 | 0.2961 | 0.0012 | 0.0042 | 0.0089 | 0.0386 | 0.0981 | 0.1463 | 0.1035 | 0.1332 | 0.4660 | 38 | 58 | 81 | 110 | 146 | 193 | 254 | 331 | 478 | 0.0038 | 52.97 | 6.523 | 0.2940 | 82615.2 | 46500000 | 32400000000 | 25600000000000 | 0.5390 | 0.1222 | 0.0251 | 0.0021 | 0.1137 | 0.0098 | 0.2109 | 0.0602 | 0.1891 | 0.0932 | 0.1683 | 0.1720 | 0.1311 | 0.1941 | 0.0678 | 0.1478 | 0.0612 | 0.1313 | 0.0328 | 0.1895 | 0.0004 | 0.0003 | 0.0021 | 0.0012 | 0.0039 | 0.0043 | 0.0189 | 0.0162 | 0.0754 | 0.0638 | 0.1190 | 0.1070 | 0.0829 | 0.0786 | 0.1187 | 0.1041 | 0.5786 | 0.6246 | 0.0011 | 0.0013 | 0.0016 | 0.0040 | 0.0080 | 0.0153 | 0.0366 | 0.0477 | 0.1115 | 0.1194 | 0.1476 | 0.1472 | 0.1041 | 0.1154 | 0.1391 | 0.1366 | 0.4503 | 0.4131 | 0.0009 | 0.0004 | 0.0043 | 0.0272 | 0.0858 | 0.1337 | 0.0923 | 0.1251 | 0.5302 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1169 | 718 | 3803 | 6960 | 84.4 | 20.56 | 84.20 | 75.35 | 60 | 68 | 73 | 77 | 82 | 88 | 94 | 101 | 111 | 0.1295 | 901 | 1.055 | 100.65 | 36.80 | 3 | 0.0702 | 267 | 0.0048 | 9.98 | 5.662 | 0.3488 | 7539.7 | 712809 | 71300000 | 7550000000 | 0.4461 | 0.2010 | 0.0035 | 0.0000 | 0.0035 | 0.0006 | 0.0133 | 0.0014 | 0.0434 | 0.0049 | 0.1018 | 0.0301 | 0.1540 | 0.0703 | 0.1717 | 0.0627 | 0.1965 | 0.1162 | 0.3124 | 0.7138 | 0.0007 | 0.0000 | 0.0013 | 0.0003 | 0.0026 | 0.0008 | 0.0141 | 0.0025 | 0.0434 | 0.0234 | 0.0736 | 0.0485 | 0.0696 | 0.0294 | 0.0923 | 0.0539 | 0.7024 | 0.8412 | 0.0038 | 0.0423 | 0.0153 | 0.0329 | 0.0204 | 0.0798 | 0.1008 | 0.1596 | 0.1288 | 0.1831 | 0.1760 | 0.2019 | 0.1492 | 0.1221 | 0.1620 | 0.0845 | 0.2436 | 0.0939 | 0.0016 | 0.0066 | 0.0131 | 0.0334 | 0.0826 | 0.1067 | 0.1100 | 0.1379 | 0.5082 | 21 | 29 | 36 | 45 | 57 | 72 | 93 | 129 | 196 | 0.0215 | 6.08 | 4.792 | 0.5469 | 12767.1 | 2810000 | 768000000 | 242000000000 | 0.5949 | 0.1190 | 0.0236 | 0.0027 | 0.0754 | 0.0155 | 0.1471 | 0.0354 | 0.1680 | 0.0787 | 0.1916 | 0.1437 | 0.1471 | 0.1641 | 0.1235 | 0.1433 | 0.0836 | 0.1636 | 0.0400 | 0.2530 | 0.0027 | 0.0010 | 0.0061 | 0.0052 | 0.0097 | 0.0081 | 0.0289 | 0.0240 | 0.0729 | 0.0672 | 0.1069 | 0.0930 | 0.0901 | 0.0750 | 0.1103 | 0.1066 | 0.5724 | 0.6198 | 0.0048 | 0.0038 | 0.0112 | 0.0038 | 0.0117 | 0.0102 | 0.0363 | 0.0326 | 0.0811 | 0.0856 | 0.1323 | 0.1475 | 0.0961 | 0.0958 | 0.1126 | 0.1315 | 0.5139 | 0.4891 | 0.0013 | 0.0093 | 0.0160 | 0.0388 | 0.0835 | 0.1210 | 0.0923 | 0.1151 | 0.5228 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1074 | 767 | 4851 | 8558 | 206.5 | 55.00 | 108.27 | 109.37 | 139 | 160 | 174 | 187 | 202 | 217 | 232 | 251 | 282 | 0.1187 | 1016 | 0.484 | 105.59 | 20.81 | 4 | 0.0662 | 321 | 0.0008 | 57.36 | 7.309 | 0.1587 | 45680.7 | 10800000 | 2680000000 | 703000000000 | 0.4637 | 0.1868 | 0.0000 | 0.0000 | 0.0015 | 0.0000 | 0.0086 | 0.0009 | 0.0413 | 0.0069 | 0.0994 | 0.0313 | 0.1640 | 0.0778 | 0.1659 | 0.0680 | 0.1872 | 0.1041 | 0.3321 | 0.7110 | 0.0000 | 0.0000 | 0.0005 | 0.0000 | 0.0019 | 0.0006 | 0.0119 | 0.0039 | 0.0380 | 0.0199 | 0.0697 | 0.0448 | 0.0629 | 0.0307 | 0.0941 | 0.0474 | 0.7209 | 0.8527 | 0.0078 | 0.0123 | 0.0059 | 0.0123 | 0.0157 | 0.0567 | 0.0793 | 0.0961 | 0.1360 | 0.1995 | 0.1634 | 0.1847 | 0.1164 | 0.1059 | 0.1585 | 0.1256 | 0.3170 | 0.2069 | 0.0000 | 0.0013 | 0.0048 | 0.0255 | 0.0867 | 0.1175 | 0.1122 | 0.1373 | 0.5147 | 12 | 18 | 29 | 47 | 69 | 99 | 134 | 187 | 268 | 0.0244 | 13.32 | 5.257 | 0.4878 | 23683.4 | 7140000 | 2580000000 | 1050000000000 | 0.5580 | 0.1201 | 0.0405 | 0.0014 | 0.1364 | 0.0151 | 0.1957 | 0.0713 | 0.2286 | 0.1138 | 0.1722 | 0.1731 | 0.1091 | 0.2097 | 0.0640 | 0.1398 | 0.0301 | 0.1316 | 0.0235 | 0.1444 | 0.0008 | 0.0007 | 0.0029 | 0.0009 | 0.0080 | 0.0059 | 0.0252 | 0.0204 | 0.0707 | 0.0557 | 0.1162 | 0.1042 | 0.0849 | 0.0847 | 0.1154 | 0.1074 | 0.5760 | 0.6202 | 0.0007 | 0.0027 | 0.0045 | 0.0063 | 0.0142 | 0.0144 | 0.0359 | 0.0395 | 0.0864 | 0.0997 | 0.1253 | 0.1307 | 0.1029 | 0.1150 | 0.1377 | 0.1370 | 0.4923 | 0.4546 | 0.0019 | 0.0031 | 0.0084 | 0.0273 | 0.0769 | 0.1256 | 0.0924 | 0.1293 | 0.5352 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 923 | 876 | 4650 | 27974 | 298.2 | 83.39 | 212.92 | 186.19 | 196 | 225 | 246 | 269 | 291 | 315 | 341 | 374 | 413 | 0.0507 | 1418 | 1.135 | 46.75 | 17.00 | 6 | 0.0265 | 123 | 0.0006 | 64.25 | 7.641 | 0.1408 | 95900.4 | 32900000 | 11900000000 | 4530000000000 | 0.4875 | 0.1659 | 0.0004 | 0.0000 | 0.0022 | 0.0008 | 0.0057 | 0.0008 | 0.0284 | 0.0091 | 0.1091 | 0.0467 | 0.1916 | 0.0965 | 0.1414 | 0.0657 | 0.1689 | 0.1033 | 0.3522 | 0.6771 | 0.0000 | 0.0000 | 0.0009 | 0.0007 | 0.0020 | 0.0000 | 0.0128 | 0.0059 | 0.0483 | 0.0320 | 0.0762 | 0.0692 | 0.0556 | 0.0391 | 0.0829 | 0.0608 | 0.7213 | 0.7923 | 0.0017 | 0.0048 | 0.0035 | 0.0095 | 0.0096 | 0.0263 | 0.0192 | 0.0668 | 0.0925 | 0.1265 | 0.1187 | 0.1384 | 0.0855 | 0.1289 | 0.1309 | 0.1480 | 0.5384 | 0.3508 | 0.0014 | 0.0009 | 0.0059 | 0.0237 | 0.0702 | 0.0916 | 0.0766 | 0.0861 | 0.6436 | 27 | 52 | 83 | 117 | 157 | 208 | 270 | 356 | 482 | 0.0050 | 46.50 | 6.695 | 0.3231 | 79998.9 | 40100000 | 24000000000 | 16200000000000 | 0.4940 | 0.1623 | 0.0270 | 0.0010 | 0.1183 | 0.0111 | 0.2093 | 0.0488 | 0.1802 | 0.0945 | 0.1620 | 0.1643 | 0.1329 | 0.2010 | 0.0821 | 0.1517 | 0.0530 | 0.1382 | 0.0352 | 0.1895 | 0.0007 | 0.0001 | 0.0014 | 0.0010 | 0.0042 | 0.0026 | 0.0218 | 0.0137 | 0.0642 | 0.0508 | 0.1052 | 0.0828 | 0.0816 | 0.0668 | 0.1081 | 0.0927 | 0.6129 | 0.6894 | 0.0013 | 0.0016 | 0.0028 | 0.0069 | 0.0105 | 0.0144 | 0.0378 | 0.0507 | 0.0975 | 0.1038 | 0.1384 | 0.1575 | 0.1063 | 0.1060 | 0.1287 | 0.1379 | 0.4767 | 0.4212 | 0.0009 | 0.0024 | 0.0075 | 0.0292 | 0.0795 | 0.1238 | 0.0924 | 0.1217 | 0.5426 | |
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1055 | 344 | 487 | 5051 | 49.0 | 12.36 | 116.43 | 167.87 | 32 | 38 | 43 | 46 | 49 | 52 | 55 | 59 | 65 | 0.0810 | 409 | 1.242 | 45.35 | 19.21 | 2 | 0.2485 | 121 | 0.0057 | 11.72 | 5.356 | 0.3095 | 2555.8 | 140162 | 8020000 | 475000000 | 0.4385 | 0.1798 | 0.0000 | 0.0000 | 0.0075 | 0.0000 | 0.0522 | 0.0000 | 0.1045 | 0.0189 | 0.1604 | 0.0731 | 0.1604 | 0.0967 | 0.1642 | 0.1250 | 0.1604 | 0.1627 | 0.1903 | 0.5236 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0027 | 0.0000 | 0.0293 | 0.0177 | 0.0745 | 0.0576 | 0.0931 | 0.0665 | 0.1356 | 0.0687 | 0.1330 | 0.1020 | 0.5319 | 0.6874 | 0.0093 | 0.0370 | 0.0278 | 0.1111 | 0.0185 | 0.1481 | 0.1574 | 0.1852 | 0.1296 | 0.2222 | 0.2130 | 0.1481 | 0.1481 | 0.1111 | 0.1389 | 0.0000 | 0.1574 | 0.0370 | 0.0000 | 0.0000 | 0.0038 | 0.0651 | 0.1149 | 0.1609 | 0.1686 | 0.1801 | 0.3065 | 21 | 24 | 27 | 33 | 48 | 74 | 108 | 161 | 274 | 0.0561 | 13.35 | 4.308 | 0.5688 | 41728.7 | 26200000 | 21000000000 | 19200000000000 | 0.6628 | 0.0772 | 0.0483 | 0.0009 | 0.1324 | 0.0250 | 0.1843 | 0.1026 | 0.1395 | 0.1100 | 0.1467 | 0.1590 | 0.1521 | 0.1654 | 0.0912 | 0.1451 | 0.0644 | 0.1146 | 0.0411 | 0.1774 | 0.0000 | 0.0000 | 0.0012 | 0.0014 | 0.0035 | 0.0029 | 0.0260 | 0.0211 | 0.0860 | 0.0694 | 0.1166 | 0.0991 | 0.0912 | 0.0804 | 0.1396 | 0.1197 | 0.5361 | 0.6060 | 0.0009 | 0.0000 | 0.0043 | 0.0050 | 0.0068 | 0.0099 | 0.0324 | 0.0417 | 0.1107 | 0.1202 | 0.1388 | 0.1400 | 0.0894 | 0.1043 | 0.1516 | 0.1589 | 0.4651 | 0.4201 | 0.0014 | 0.0007 | 0.0085 | 0.0318 | 0.1108 | 0.1200 | 0.0924 | 0.1623 | 0.4721 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 974 | 491 | 2075 | 6138 | 79.2 | 16.85 | 226.62 | 224.68 | 59 | 65 | 70 | 74 | 77 | 82 | 86 | 93 | 102 | 0.0632 | 388 | 0.768 | 127.88 | 34.79 | 1 | 0.1566 | 325 | 0.0032 | 15.64 | 6.011 | 0.2726 | 6562.2 | 567309 | 51100000 | 4800000000 | 0.4688 | 0.1916 | 0.0007 | 0.0000 | 0.0007 | 0.0000 | 0.0073 | 0.0005 | 0.0278 | 0.0010 | 0.0805 | 0.0234 | 0.1426 | 0.0426 | 0.1500 | 0.0483 | 0.2004 | 0.0701 | 0.3899 | 0.8141 | 0.0000 | 0.0000 | 0.0006 | 0.0000 | 0.0012 | 0.0000 | 0.0063 | 0.0000 | 0.0322 | 0.0138 | 0.0679 | 0.0256 | 0.0621 | 0.0177 | 0.1059 | 0.0290 | 0.7238 | 0.9140 | 0.0081 | 0.0370 | 0.0270 | 0.0278 | 0.0377 | 0.0926 | 0.0916 | 0.0833 | 0.1456 | 0.1759 | 0.1806 | 0.2407 | 0.1294 | 0.1204 | 0.1240 | 0.1852 | 0.2561 | 0.0370 | 0.0030 | 0.0071 | 0.0163 | 0.0346 | 0.0925 | 0.1209 | 0.1189 | 0.1423 | 0.4644 | 24 | 43 | 68 | 98 | 138 | 204 | 294 | 397 | 550 | 0.0072 | 49.76 | 6.356 | 0.3422 | 101826.0 | 62200000 | 45000000000 | 36400000000000 | 0.4500 | 0.1910 | 0.0311 | 0.0000 | 0.1627 | 0.0071 | 0.2825 | 0.0767 | 0.1686 | 0.1526 | 0.1361 | 0.1859 | 0.1124 | 0.2314 | 0.0503 | 0.1313 | 0.0355 | 0.0987 | 0.0207 | 0.1164 | 0.0008 | 0.0000 | 0.0023 | 0.0013 | 0.0011 | 0.0016 | 0.0106 | 0.0107 | 0.0513 | 0.0417 | 0.1124 | 0.1059 | 0.0724 | 0.0672 | 0.1116 | 0.0820 | 0.6376 | 0.6897 | 0.0000 | 0.0012 | 0.0005 | 0.0030 | 0.0056 | 0.0077 | 0.0192 | 0.0195 | 0.0709 | 0.0936 | 0.1478 | 0.1647 | 0.1063 | 0.1043 | 0.1184 | 0.1345 | 0.5314 | 0.4716 | 0.0004 | 0.0013 | 0.0053 | 0.0149 | 0.0605 | 0.1329 | 0.0925 | 0.1136 | 0.5785 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 821 | 296 | 10441 | 19427 | 121.6 | 37.86 | 144.94 | 161.51 | 79 | 90 | 99 | 108 | 116 | 126 | 138 | 153 | 174 | 0.0627 | 1218 | 0.254 | 218.68 | 45.79 | 4 | 0.0876 | 915 | 0.0020 | 18.42 | 6.592 | 0.2752 | 16229.4 | 2350000 | 367000000 | 61000000000 | 0.4705 | 0.1773 | 0.0012 | 0.0001 | 0.0034 | 0.0006 | 0.0120 | 0.0011 | 0.0412 | 0.0074 | 0.1063 | 0.0358 | 0.1638 | 0.0724 | 0.1588 | 0.0758 | 0.1756 | 0.1072 | 0.3378 | 0.6997 | 0.0007 | 0.0001 | 0.0015 | 0.0001 | 0.0029 | 0.0005 | 0.0135 | 0.0023 | 0.0368 | 0.0171 | 0.0641 | 0.0363 | 0.0621 | 0.0302 | 0.0774 | 0.0464 | 0.7412 | 0.8670 | 0.0044 | 0.0067 | 0.0016 | 0.0117 | 0.0148 | 0.0341 | 0.0487 | 0.0908 | 0.0907 | 0.1341 | 0.1362 | 0.1882 | 0.1286 | 0.1440 | 0.1354 | 0.1440 | 0.4395 | 0.2465 | 0.0006 | 0.0041 | 0.0103 | 0.0299 | 0.0638 | 0.1050 | 0.0907 | 0.1158 | 0.5798 | 11 | 14 | 20 | 40 | 78 | 132 | 194 | 273 | 378 | 0.0407 | 25.51 | 5.518 | 0.4667 | 47091.3 | 20600000 | 10800000000 | 6430000000000 | 0.5620 | 0.1280 | 0.0686 | 0.0021 | 0.1796 | 0.0256 | 0.2678 | 0.1420 | 0.1409 | 0.1373 | 0.1146 | 0.1747 | 0.0965 | 0.1718 | 0.0578 | 0.1136 | 0.0428 | 0.1049 | 0.0315 | 0.1281 | 0.0001 | 0.0004 | 0.0010 | 0.0007 | 0.0020 | 0.0019 | 0.0094 | 0.0061 | 0.0535 | 0.0466 | 0.1056 | 0.0854 | 0.0759 | 0.0627 | 0.1166 | 0.0964 | 0.6358 | 0.6997 | 0.0008 | 0.0011 | 0.0017 | 0.0029 | 0.0042 | 0.0088 | 0.0152 | 0.0241 | 0.0795 | 0.0957 | 0.1485 | 0.1575 | 0.0994 | 0.1066 | 0.1429 | 0.1449 | 0.5079 | 0.4585 | 0.0003 | 0.0016 | 0.0031 | 0.0113 | 0.0700 | 0.1221 | 0.0927 | 0.1315 | 0.5675 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1135 | 892 | 1409 | 5293 | 134.3 | 28.05 | 123.64 | 119.19 | 100 | 110 | 119 | 126 | 133 | 139 | 146 | 156 | 174 | 0.1398 | 740 | 0.560 | 124.49 | 24.84 | 1 | 0.2342 | 330 | 0.0027 | 21.21 | 6.129 | 0.2523 | 18811.5 | 2740000 | 416000000 | 65400000000 | 0.4105 | 0.2378 | 0.0011 | 0.0000 | 0.0043 | 0.0000 | 0.0075 | 0.0015 | 0.0247 | 0.0053 | 0.0816 | 0.0356 | 0.1633 | 0.0734 | 0.1429 | 0.0552 | 0.1665 | 0.0953 | 0.4082 | 0.7337 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0043 | 0.0000 | 0.0120 | 0.0036 | 0.0463 | 0.0252 | 0.0892 | 0.0533 | 0.0729 | 0.0259 | 0.0892 | 0.0497 | 0.6861 | 0.8423 | 0.0043 | 0.0000 | 0.0043 | 0.0746 | 0.0468 | 0.1493 | 0.0766 | 0.2239 | 0.1489 | 0.2388 | 0.1362 | 0.1045 | 0.0894 | 0.0896 | 0.1574 | 0.0746 | 0.3362 | 0.0448 | 0.0029 | 0.0044 | 0.0190 | 0.0452 | 0.0860 | 0.1472 | 0.1297 | 0.1356 | 0.4300 | 24 | 32 | 40 | 53 | 72 | 105 | 153 | 214 | 303 | 0.0149 | 12.61 | 5.403 | 0.4666 | 29488.2 | 9730000 | 3860000000 | 1750000000000 | 0.6071 | 0.1012 | 0.0703 | 0.0066 | 0.2148 | 0.0303 | 0.2890 | 0.0917 | 0.1787 | 0.1523 | 0.1274 | 0.1941 | 0.0837 | 0.2007 | 0.0209 | 0.1302 | 0.0114 | 0.1007 | 0.0038 | 0.0934 | 0.0009 | 0.0015 | 0.0032 | 0.0035 | 0.0111 | 0.0112 | 0.0263 | 0.0235 | 0.0783 | 0.0666 | 0.1188 | 0.1150 | 0.0866 | 0.0850 | 0.1152 | 0.1070 | 0.5597 | 0.5868 | 0.0000 | 0.0036 | 0.0043 | 0.0065 | 0.0201 | 0.0203 | 0.0419 | 0.0443 | 0.0906 | 0.1074 | 0.1404 | 0.1350 | 0.1021 | 0.1103 | 0.1319 | 0.1321 | 0.4687 | 0.4405 | 0.0016 | 0.0037 | 0.0058 | 0.0288 | 0.0885 | 0.1257 | 0.0927 | 0.1225 | 0.5309 | |
MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 786 | 723 | 4403 | 10505 | 156.8 | 37.21 | 158.32 | 156.07 | 111 | 125 | 136 | 145 | 154 | 163 | 173 | 187 | 207 | 0.0730 | 767 | 1.082 | 105.15 | 39.01 | 1 | 0.0620 | 273 | 0.0017 | 27.23 | 6.665 | 0.2280 | 25980.4 | 4530000 | 831000000 | 159000000000 | 0.4286 | 0.2358 | 0.0007 | 0.0000 | 0.0045 | 0.0003 | 0.0138 | 0.0018 | 0.0302 | 0.0040 | 0.0832 | 0.0260 | 0.1542 | 0.0510 | 0.1486 | 0.0545 | 0.1725 | 0.0808 | 0.3923 | 0.7817 | 0.0000 | 0.0000 | 0.0009 | 0.0002 | 0.0009 | 0.0002 | 0.0068 | 0.0009 | 0.0392 | 0.0176 | 0.0717 | 0.0309 | 0.0697 | 0.0248 | 0.0958 | 0.0405 | 0.7151 | 0.8849 | 0.0024 | 0.0182 | 0.0155 | 0.0146 | 0.0274 | 0.0474 | 0.0764 | 0.1314 | 0.1372 | 0.1788 | 0.2076 | 0.2336 | 0.1313 | 0.0985 | 0.1396 | 0.1314 | 0.2625 | 0.1460 | 0.0024 | 0.0015 | 0.0068 | 0.0336 | 0.0973 | 0.1357 | 0.1051 | 0.1367 | 0.4810 | 15 | 27 | 45 | 75 | 110 | 150 | 199 | 265 | 380 | 0.0051 | 65.67 | 6.760 | 0.3104 | 49420.1 | 21200000 | 11000000000 | 6460000000000 | 0.5076 | 0.1389 | 0.0172 | 0.0010 | 0.0968 | 0.0078 | 0.2177 | 0.0413 | 0.1765 | 0.0889 | 0.1820 | 0.1633 | 0.1360 | 0.1965 | 0.0859 | 0.1508 | 0.0522 | 0.1403 | 0.0357 | 0.2100 | 0.0006 | 0.0000 | 0.0015 | 0.0009 | 0.0038 | 0.0042 | 0.0125 | 0.0116 | 0.0563 | 0.0446 | 0.0987 | 0.0767 | 0.0747 | 0.0616 | 0.1081 | 0.0892 | 0.6439 | 0.7113 | 0.0009 | 0.0015 | 0.0030 | 0.0036 | 0.0093 | 0.0109 | 0.0246 | 0.0318 | 0.0818 | 0.0982 | 0.1325 | 0.1383 | 0.0971 | 0.0985 | 0.1250 | 0.1438 | 0.5259 | 0.4734 | 0.0002 | 0.0017 | 0.0057 | 0.0214 | 0.0664 | 0.1176 | 0.0927 | 0.1161 | 0.5782 | |||
BT-20 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 659 | 864 | 9157 | 12600 | 572.9 | 114.09 | 133.84 | 114.82 | 435 | 475 | 505 | 534 | 563 | 594 | 628 | 666 | 723 | 0.0900 | 1134 | 1.199 | 96.51 | 40.61 | 1 | 0.0284 | 260 | 0.0005 | 84.01 | 7.780 | 0.1396 | 341248.0 | 211000000 | 136000000000 | 90100000000000 | 0.4173 | 0.2328 | 0.0000 | 0.0000 | 0.0008 | 0.0000 | 0.0013 | 0.0001 | 0.0084 | 0.0014 | 0.0529 | 0.0133 | 0.1231 | 0.0303 | 0.1329 | 0.0280 | 0.1634 | 0.0394 | 0.5172 | 0.8876 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0006 | 0.0000 | 0.0045 | 0.0001 | 0.0267 | 0.0098 | 0.0603 | 0.0210 | 0.0668 | 0.0155 | 0.0864 | 0.0211 | 0.7545 | 0.9324 | 0.0022 | 0.0060 | 0.0129 | 0.0121 | 0.0237 | 0.0423 | 0.0760 | 0.0755 | 0.1097 | 0.1631 | 0.1627 | 0.1450 | 0.0968 | 0.1329 | 0.1168 | 0.1541 | 0.3993 | 0.2689 | 0.0000 | 0.0012 | 0.0046 | 0.0244 | 0.0835 | 0.1249 | 0.1047 | 0.1165 | 0.5403 | 14 | 26 | 50 | 78 | 106 | 138 | 176 | 224 | 297 | 0.0077 | 28.76 | 6.275 | 0.3483 | 31096.2 | 9370000 | 3320000000 | 1310000000000 | 0.6019 | 0.1025 | 0.0320 | 0.0017 | 0.1338 | 0.0087 | 0.2500 | 0.0546 | 0.1658 | 0.1008 | 0.1684 | 0.1801 | 0.1271 | 0.1957 | 0.0646 | 0.1465 | 0.0413 | 0.1349 | 0.0170 | 0.1769 | 0.0005 | 0.0004 | 0.0008 | 0.0005 | 0.0031 | 0.0019 | 0.0161 | 0.0096 | 0.0663 | 0.0503 | 0.1259 | 0.0945 | 0.0830 | 0.0727 | 0.1216 | 0.1056 | 0.5828 | 0.6645 | 0.0009 | 0.0012 | 0.0042 | 0.0084 | 0.0093 | 0.0160 | 0.0313 | 0.0389 | 0.1011 | 0.1062 | 0.1497 | 0.1596 | 0.1025 | 0.1120 | 0.1383 | 0.1416 | 0.4626 | 0.4161 | 0.0008 | 0.0029 | 0.0060 | 0.0229 | 0.0836 | 0.1434 | 0.0928 | 0.1261 | 0.5216 | |||
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 374 | 827 | 538 | 5755 | 91.8 | 48.44 | 171.54 | 297.95 | 29 | 40 | 57 | 74 | 89 | 101 | 116 | 140 | 161 | 0.0895 | 515 | 1.275 | 31.62 | 12.17 | 2 | 0.1543 | 83 | 0.0025 | 70.15 | 6.080 | 0.1560 | 10772.9 | 1460000 | 216000000 | 34000000000 | 0.3272 | 0.2735 | 0.0000 | 0.0000 | 0.0282 | 0.0000 | 0.1338 | 0.0000 | 0.1901 | 0.0198 | 0.1620 | 0.1581 | 0.1268 | 0.1937 | 0.1479 | 0.1621 | 0.1056 | 0.1581 | 0.1056 | 0.3083 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0031 | 0.0000 | 0.0031 | 0.0131 | 0.0800 | 0.0551 | 0.0985 | 0.0866 | 0.0431 | 0.0525 | 0.1138 | 0.0840 | 0.6585 | 0.7087 | 0.0000 | 0.0000 | 0.0000 | 0.0156 | 0.0055 | 0.0000 | 0.0383 | 0.0156 | 0.1038 | 0.1328 | 0.1038 | 0.1016 | 0.1093 | 0.1016 | 0.1421 | 0.1328 | 0.4973 | 0.5000 | 0.0000 | 0.0000 | 0.0078 | 0.0389 | 0.0661 | 0.1128 | 0.0973 | 0.1128 | 0.5642 | 17 | 19 | 20 | 22 | 25 | 35 | 92 | 249 | 645 | 0.1812 | 27.53 | 3.742 | 0.6466 | 118185.0 | 112000000 | 119000000000 | 139000000000000 | 0.7250 | 0.0477 | 0.0600 | 0.0080 | 0.2240 | 0.0282 | 0.3600 | 0.1690 | 0.1600 | 0.1932 | 0.0920 | 0.2012 | 0.0480 | 0.1469 | 0.0240 | 0.1066 | 0.0240 | 0.0624 | 0.0080 | 0.0845 | 0.0000 | 0.0000 | 0.0007 | 0.0006 | 0.0020 | 0.0012 | 0.0231 | 0.0168 | 0.0909 | 0.0895 | 0.1324 | 0.1111 | 0.0856 | 0.0847 | 0.1232 | 0.1219 | 0.5422 | 0.5742 | 0.0000 | 0.0000 | 0.0047 | 0.0060 | 0.0087 | 0.0146 | 0.0379 | 0.0368 | 0.0883 | 0.0856 | 0.1270 | 0.1336 | 0.1017 | 0.0967 | 0.1222 | 0.1182 | 0.5095 | 0.5086 | 0.0000 | 0.0000 | 0.0086 | 0.0281 | 0.0944 | 0.1354 | 0.0929 | 0.1218 | 0.5187 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1121 | 451 | 6463 | 8308 | 92.4 | 21.14 | 64.20 | 58.22 | 68 | 75 | 80 | 85 | 90 | 96 | 102 | 109 | 121 | 0.1133 | 941 | 0.502 | 162.61 | 33.73 | 3 | 0.0791 | 511 | 0.0045 | 8.67 | 5.719 | 0.3500 | 8980.8 | 917146 | 98200000 | 11000000000 | 0.4709 | 0.1844 | 0.0005 | 0.0000 | 0.0056 | 0.0000 | 0.0071 | 0.0007 | 0.0282 | 0.0044 | 0.0803 | 0.0230 | 0.1265 | 0.0487 | 0.1496 | 0.0470 | 0.1916 | 0.0838 | 0.4105 | 0.7925 | 0.0004 | 0.0000 | 0.0034 | 0.0000 | 0.0032 | 0.0003 | 0.0129 | 0.0024 | 0.0336 | 0.0144 | 0.0546 | 0.0290 | 0.0643 | 0.0214 | 0.0936 | 0.0415 | 0.7341 | 0.8910 | 0.0041 | 0.0140 | 0.0156 | 0.0420 | 0.0303 | 0.0812 | 0.0705 | 0.0980 | 0.1115 | 0.1765 | 0.1566 | 0.2185 | 0.1393 | 0.1176 | 0.1377 | 0.1289 | 0.3344 | 0.1232 | 0.0042 | 0.0088 | 0.0152 | 0.0412 | 0.0629 | 0.0960 | 0.0973 | 0.1255 | 0.5490 | 12 | 17 | 24 | 31 | 41 | 58 | 79 | 110 | 150 | 0.0333 | 4.43 | 4.417 | 0.5777 | 7511.6 | 1200000 | 227000000 | 48400000000 | 0.5963 | 0.1028 | 0.0286 | 0.0119 | 0.1026 | 0.0162 | 0.1765 | 0.0476 | 0.1913 | 0.1232 | 0.1647 | 0.1645 | 0.1479 | 0.1992 | 0.1016 | 0.1403 | 0.0572 | 0.1417 | 0.0296 | 0.1555 | 0.0025 | 0.0049 | 0.0042 | 0.0042 | 0.0053 | 0.0084 | 0.0181 | 0.0298 | 0.0577 | 0.0498 | 0.0936 | 0.0780 | 0.0747 | 0.0703 | 0.1234 | 0.1059 | 0.6206 | 0.6487 | 0.0019 | 0.0023 | 0.0058 | 0.0027 | 0.0089 | 0.0119 | 0.0314 | 0.0337 | 0.0823 | 0.0958 | 0.1366 | 0.1500 | 0.1029 | 0.1031 | 0.1300 | 0.1404 | 0.5000 | 0.4601 | 0.0019 | 0.0010 | 0.0088 | 0.0237 | 0.0703 | 0.1144 | 0.0930 | 0.1433 | 0.5436 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 831 | 627 | 22430 | 35732 | 126.0 | 38.62 | 252.74 | 227.53 | 82 | 95 | 104 | 113 | 121 | 131 | 142 | 157 | 179 | 0.0532 | 1901 | 0.880 | 73.43 | 20.81 | 2 | 0.0089 | 200 | 0.0017 | 21.99 | 6.753 | 0.2609 | 17379.7 | 2600000 | 417000000 | 71800000000 | 0.4412 | 0.2102 | 0.0006 | 0.0001 | 0.0021 | 0.0002 | 0.0088 | 0.0011 | 0.0346 | 0.0052 | 0.1045 | 0.0291 | 0.1823 | 0.0693 | 0.1643 | 0.0693 | 0.1767 | 0.0997 | 0.3261 | 0.7259 | 0.0002 | 0.0001 | 0.0008 | 0.0001 | 0.0022 | 0.0002 | 0.0101 | 0.0018 | 0.0357 | 0.0141 | 0.0709 | 0.0319 | 0.0688 | 0.0258 | 0.0917 | 0.0432 | 0.7197 | 0.8826 | 0.0034 | 0.0054 | 0.0050 | 0.0100 | 0.0140 | 0.0284 | 0.0533 | 0.0888 | 0.0998 | 0.1568 | 0.1659 | 0.2106 | 0.1164 | 0.1172 | 0.1451 | 0.1426 | 0.3972 | 0.2402 | 0.0011 | 0.0034 | 0.0087 | 0.0271 | 0.0720 | 0.1160 | 0.1006 | 0.1196 | 0.5516 | 16 | 33 | 75 | 138 | 204 | 273 | 343 | 432 | 576 | 0.0082 | 55.93 | 6.842 | 0.3237 | 115644.0 | 68100000 | 47400000000 | 37300000000000 | 0.5184 | 0.1555 | 0.0294 | 0.0010 | 0.1132 | 0.0078 | 0.2146 | 0.0613 | 0.1758 | 0.0954 | 0.1640 | 0.1647 | 0.1397 | 0.1993 | 0.0852 | 0.1472 | 0.0476 | 0.1393 | 0.0304 | 0.1840 | 0.0000 | 0.0002 | 0.0006 | 0.0007 | 0.0018 | 0.0015 | 0.0125 | 0.0070 | 0.0472 | 0.0386 | 0.0990 | 0.0797 | 0.0795 | 0.0590 | 0.1063 | 0.0906 | 0.6532 | 0.7227 | 0.0006 | 0.0013 | 0.0027 | 0.0029 | 0.0077 | 0.0109 | 0.0241 | 0.0340 | 0.0806 | 0.1011 | 0.1356 | 0.1539 | 0.1094 | 0.1178 | 0.1359 | 0.1438 | 0.5033 | 0.4344 | 0.0003 | 0.0016 | 0.0049 | 0.0169 | 0.0624 | 0.1189 | 0.0930 | 0.1202 | 0.5819 | |
MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 595 | 443 | 5995 | 10600 | 127.3 | 28.53 | 123.95 | 93.46 | 93 | 103 | 111 | 117 | 124 | 131 | 139 | 150 | 166 | 0.0878 | 931 | 1.110 | 107.91 | 35.51 | 1 | 0.0454 | 272 | 0.0024 | 17.97 | 6.317 | 0.2686 | 17011.3 | 2390000 | 351000000 | 54200000000 | 0.4279 | 0.2247 | 0.0003 | 0.0000 | 0.0016 | 0.0000 | 0.0081 | 0.0009 | 0.0256 | 0.0032 | 0.0811 | 0.0218 | 0.1460 | 0.0470 | 0.1630 | 0.0517 | 0.1863 | 0.0761 | 0.3880 | 0.7993 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0020 | 0.0003 | 0.0092 | 0.0008 | 0.0374 | 0.0147 | 0.0669 | 0.0251 | 0.0697 | 0.0229 | 0.0981 | 0.0354 | 0.7162 | 0.9007 | 0.0056 | 0.0116 | 0.0112 | 0.0462 | 0.0243 | 0.0520 | 0.1104 | 0.1185 | 0.1375 | 0.2110 | 0.1908 | 0.2052 | 0.1272 | 0.1098 | 0.1197 | 0.1214 | 0.2732 | 0.1243 | 0.0029 | 0.0029 | 0.0118 | 0.0319 | 0.0937 | 0.1342 | 0.1202 | 0.1461 | 0.4562 | 21 | 35 | 53 | 77 | 105 | 135 | 167 | 204 | 256 | 0.0045 | 24.94 | 6.421 | 0.3407 | 24096.0 | 5870000 | 1650000000 | 518000000000 | 0.4887 | 0.1638 | 0.0159 | 0.0014 | 0.0819 | 0.0078 | 0.2092 | 0.0351 | 0.1715 | 0.0762 | 0.1821 | 0.1512 | 0.1520 | 0.2185 | 0.0825 | 0.1455 | 0.0631 | 0.1599 | 0.0418 | 0.2044 | 0.0011 | 0.0006 | 0.0016 | 0.0008 | 0.0036 | 0.0029 | 0.0113 | 0.0087 | 0.0506 | 0.0382 | 0.0872 | 0.0805 | 0.0734 | 0.0558 | 0.1058 | 0.0924 | 0.6654 | 0.7202 | 0.0018 | 0.0020 | 0.0026 | 0.0030 | 0.0084 | 0.0100 | 0.0221 | 0.0341 | 0.0767 | 0.0955 | 0.1270 | 0.1543 | 0.1088 | 0.1172 | 0.1486 | 0.1606 | 0.5040 | 0.4234 | 0.0007 | 0.0007 | 0.0050 | 0.0176 | 0.0665 | 0.0987 | 0.0932 | 0.1319 | 0.5858 | |||
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1109 | 791 | 9893 | 20116 | 97.3 | 34.99 | 152.25 | 139.00 | 59 | 71 | 78 | 85 | 92 | 100 | 109 | 122 | 142 | 0.0680 | 1367 | 0.691 | 64.66 | 21.00 | 2 | 0.0208 | 206 | 0.0011 | 48.57 | 7.180 | 0.2021 | 10687.4 | 1320000 | 184000000 | 28700000000 | 0.5283 | 0.1408 | 0.0017 | 0.0000 | 0.0030 | 0.0003 | 0.0286 | 0.0013 | 0.0650 | 0.0096 | 0.1374 | 0.0448 | 0.1825 | 0.0976 | 0.1668 | 0.0904 | 0.1696 | 0.1321 | 0.2454 | 0.6238 | 0.0009 | 0.0000 | 0.0010 | 0.0001 | 0.0048 | 0.0001 | 0.0158 | 0.0049 | 0.0504 | 0.0240 | 0.0807 | 0.0492 | 0.0728 | 0.0375 | 0.1094 | 0.0633 | 0.6642 | 0.8209 | 0.0008 | 0.0032 | 0.0055 | 0.0144 | 0.0152 | 0.0335 | 0.0601 | 0.0813 | 0.1261 | 0.1491 | 0.1582 | 0.1914 | 0.1290 | 0.1148 | 0.1472 | 0.1260 | 0.3579 | 0.2863 | 0.0016 | 0.0025 | 0.0094 | 0.0338 | 0.0912 | 0.1218 | 0.1065 | 0.1342 | 0.4990 | 16 | 34 | 57 | 83 | 111 | 147 | 192 | 251 | 344 | 0.0118 | 24.15 | 5.952 | 0.3916 | 42501.1 | 16300000 | 7740000000 | 4260000000000 | 0.4988 | 0.1607 | 0.0275 | 0.0011 | 0.1169 | 0.0097 | 0.2130 | 0.0538 | 0.1636 | 0.0856 | 0.1683 | 0.1643 | 0.1424 | 0.1882 | 0.0820 | 0.1427 | 0.0568 | 0.1438 | 0.0296 | 0.2107 | 0.0004 | 0.0003 | 0.0017 | 0.0007 | 0.0039 | 0.0041 | 0.0160 | 0.0085 | 0.0595 | 0.0462 | 0.1060 | 0.0850 | 0.0867 | 0.0678 | 0.1130 | 0.1003 | 0.6127 | 0.6871 | 0.0008 | 0.0017 | 0.0031 | 0.0057 | 0.0093 | 0.0109 | 0.0287 | 0.0382 | 0.0867 | 0.1002 | 0.1526 | 0.1644 | 0.1028 | 0.1095 | 0.1329 | 0.1367 | 0.4830 | 0.4326 | 0.0001 | 0.0023 | 0.0070 | 0.0206 | 0.0702 | 0.1325 | 0.0932 | 0.1236 | 0.5506 | |
Hs 578T | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 854 | 856 | 7221 | 14570 | 49.4 | 17.53 | 78.00 | 136.28 | 28 | 34 | 38 | 43 | 47 | 52 | 58 | 64 | 73 | 0.0925 | 1347 | 0.564 | 226.82 | 39.32 | 13 | 0.0867 | 626 | 0.0060 | 6.82 | 5.419 | 0.3768 | 2746.4 | 169000 | 11300000 | 819000000 | 0.4385 | 0.1979 | 0.0021 | 0.0002 | 0.0092 | 0.0013 | 0.0509 | 0.0036 | 0.1206 | 0.0209 | 0.1835 | 0.0519 | 0.1998 | 0.1171 | 0.1729 | 0.1192 | 0.1266 | 0.1517 | 0.1344 | 0.5342 | 0.0004 | 0.0000 | 0.0012 | 0.0005 | 0.0037 | 0.0013 | 0.0217 | 0.0112 | 0.0562 | 0.0266 | 0.0864 | 0.0540 | 0.0848 | 0.0579 | 0.1085 | 0.0691 | 0.6371 | 0.7796 | 0.0039 | 0.0097 | 0.0073 | 0.0154 | 0.0194 | 0.0328 | 0.0682 | 0.0936 | 0.1094 | 0.1380 | 0.1510 | 0.1979 | 0.1292 | 0.1342 | 0.1549 | 0.1467 | 0.3567 | 0.2317 | 0.0017 | 0.0026 | 0.0125 | 0.0408 | 0.0755 | 0.1098 | 0.1078 | 0.1329 | 0.5163 | 11 | 13 | 15 | 17 | 20 | 26 | 46 | 104 | 234 | 0.1860 | 10.58 | 3.510 | 0.6862 | 24655.2 | 13200000 | 8940000000 | 7000000000000 | 0.6410 | 0.1101 | 0.1548 | 0.0039 | 0.3289 | 0.0394 | 0.2946 | 0.2229 | 0.1131 | 0.2327 | 0.0565 | 0.2189 | 0.0298 | 0.1433 | 0.0134 | 0.0671 | 0.0074 | 0.0493 | 0.0015 | 0.0224 | 0.0008 | 0.0002 | 0.0008 | 0.0005 | 0.0032 | 0.0053 | 0.0201 | 0.0138 | 0.0823 | 0.0766 | 0.1173 | 0.0994 | 0.0839 | 0.0713 | 0.1284 | 0.1266 | 0.5631 | 0.6063 | 0.0003 | 0.0007 | 0.0023 | 0.0021 | 0.0058 | 0.0053 | 0.0229 | 0.0248 | 0.1011 | 0.1076 | 0.1308 | 0.1522 | 0.0995 | 0.0995 | 0.1485 | 0.1501 | 0.4889 | 0.4577 | 0.0000 | 0.0023 | 0.0053 | 0.0197 | 0.0978 | 0.1169 | 0.0934 | 0.1436 | 0.5211 | |
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 789 | 385 | 5318 | 5252 | 117.1 | 28.29 | 183.50 | 149.81 | 88 | 95 | 101 | 106 | 111 | 118 | 126 | 135 | 153 | 0.1359 | 714 | 1.185 | 99.25 | 31.11 | 1 | 0.0440 | 234 | 0.0038 | 12.98 | 5.962 | 0.3134 | 14501.7 | 1920000 | 277000000 | 44100000000 | 0.4157 | 0.2302 | 0.0009 | 0.0000 | 0.0020 | 0.0000 | 0.0054 | 0.0000 | 0.0148 | 0.0014 | 0.0594 | 0.0200 | 0.1213 | 0.0451 | 0.1410 | 0.0401 | 0.1627 | 0.0615 | 0.4926 | 0.8319 | 0.0007 | 0.0000 | 0.0011 | 0.0000 | 0.0032 | 0.0000 | 0.0092 | 0.0002 | 0.0304 | 0.0127 | 0.0533 | 0.0251 | 0.0612 | 0.0134 | 0.0839 | 0.0215 | 0.7570 | 0.9271 | 0.0036 | 0.0085 | 0.0107 | 0.0142 | 0.0130 | 0.0342 | 0.0627 | 0.0883 | 0.1456 | 0.2023 | 0.1692 | 0.1766 | 0.0994 | 0.0855 | 0.1669 | 0.1595 | 0.3290 | 0.2308 | 0.0013 | 0.0072 | 0.0103 | 0.0354 | 0.0752 | 0.1150 | 0.1115 | 0.1352 | 0.5090 | 34 | 56 | 79 | 108 | 140 | 180 | 233 | 298 | 398 | 0.0028 | 51.84 | 6.696 | 0.3006 | 56111.0 | 22900000 | 11200000000 | 6260000000000 | 0.5751 | 0.1077 | 0.0275 | 0.0017 | 0.1066 | 0.0098 | 0.2575 | 0.0574 | 0.1760 | 0.1074 | 0.1701 | 0.1895 | 0.1401 | 0.1959 | 0.0671 | 0.1430 | 0.0299 | 0.1310 | 0.0251 | 0.1643 | 0.0008 | 0.0000 | 0.0024 | 0.0010 | 0.0052 | 0.0029 | 0.0226 | 0.0226 | 0.0755 | 0.0634 | 0.1156 | 0.0976 | 0.0898 | 0.0789 | 0.1017 | 0.0957 | 0.5866 | 0.6379 | 0.0012 | 0.0007 | 0.0024 | 0.0052 | 0.0125 | 0.0163 | 0.0458 | 0.0570 | 0.0903 | 0.1117 | 0.1729 | 0.1805 | 0.1028 | 0.1139 | 0.1147 | 0.1220 | 0.4575 | 0.3928 | 0.0005 | 0.0044 | 0.0068 | 0.0311 | 0.0856 | 0.1465 | 0.0934 | 0.1226 | 0.5090 | |
MCF 10A | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 1024 | 846 | 3435 | 10087 | 659.3 | 219.85 | 229.57 | 300.23 | 381 | 422 | 474 | 560 | 656 | 739 | 815 | 886 | 962 | 0.0675 | 681 | 1.178 | 50.36 | 19.72 | 1 | 0.0387 | 133 | 0.0016 | 33.09 | 6.859 | 0.2760 | 482935.0 | 384000000 | 323000000000 | 284000000000000 | 0.4698 | 0.1835 | 0.0010 | 0.0008 | 0.0010 | 0.0008 | 0.0190 | 0.0041 | 0.0543 | 0.0094 | 0.1514 | 0.0513 | 0.2114 | 0.0871 | 0.1162 | 0.0675 | 0.1257 | 0.1037 | 0.3200 | 0.6753 | 0.0000 | 0.0007 | 0.0000 | 0.0000 | 0.0000 | 0.0014 | 0.0027 | 0.0044 | 0.0321 | 0.0267 | 0.0715 | 0.0507 | 0.0357 | 0.0311 | 0.0632 | 0.0504 | 0.7948 | 0.8347 | 0.0009 | 0.0040 | 0.0009 | 0.0040 | 0.0053 | 0.0180 | 0.0132 | 0.0360 | 0.0618 | 0.0900 | 0.1103 | 0.1260 | 0.0688 | 0.1200 | 0.0980 | 0.1420 | 0.6408 | 0.4600 | 0.0000 | 0.0000 | 0.0000 | 0.0047 | 0.0445 | 0.0890 | 0.0504 | 0.0878 | 0.7237 | 18 | 25 | 41 | 66 | 110 | 168 | 254 | 377 | 603 | 0.0320 | 31.34 | 5.547 | 0.4433 | 142832.0 | 138000000 | 168000000000 | 236000000000000 | 0.5550 | 0.1375 | 0.0682 | 0.0019 | 0.1896 | 0.0238 | 0.3009 | 0.1211 | 0.1665 | 0.1477 | 0.1254 | 0.1809 | 0.0832 | 0.1847 | 0.0401 | 0.1328 | 0.0191 | 0.1164 | 0.0070 | 0.0907 | 0.0003 | 0.0002 | 0.0011 | 0.0004 | 0.0087 | 0.0040 | 0.0184 | 0.0141 | 0.0784 | 0.0693 | 0.1286 | 0.1141 | 0.0920 | 0.0812 | 0.1286 | 0.1212 | 0.5440 | 0.5954 | 0.0007 | 0.0021 | 0.0029 | 0.0050 | 0.0103 | 0.0117 | 0.0271 | 0.0364 | 0.0934 | 0.0899 | 0.1497 | 0.1527 | 0.0984 | 0.0933 | 0.1297 | 0.1217 | 0.4879 | 0.4872 | 0.0015 | 0.0018 | 0.0095 | 0.0160 | 0.0812 | 0.1482 | 0.0935 | 0.1316 | 0.5166 | |
MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 396 | 817 | 4083 | 6204 | 171.9 | 49.75 | 200.16 | 197.44 | 116 | 132 | 144 | 155 | 165 | 176 | 190 | 208 | 235 | 0.1065 | 661 | 1.221 | 103.16 | 41.87 | 1 | 0.0649 | 265 | 0.0012 | 45.98 | 6.996 | 0.1927 | 32023.5 | 6460000 | 1410000000 | 334000000000 | 0.4304 | 0.2154 | 0.0000 | 0.0000 | 0.0009 | 0.0000 | 0.0147 | 0.0000 | 0.0334 | 0.0020 | 0.1068 | 0.0322 | 0.2065 | 0.0772 | 0.1709 | 0.0735 | 0.1794 | 0.0958 | 0.2875 | 0.7193 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0010 | 0.0000 | 0.0068 | 0.0013 | 0.0444 | 0.0205 | 0.0995 | 0.0407 | 0.0762 | 0.0329 | 0.1105 | 0.0477 | 0.6614 | 0.8570 | 0.0036 | 0.0000 | 0.0072 | 0.0256 | 0.0191 | 0.0484 | 0.0656 | 0.0769 | 0.1514 | 0.1852 | 0.1907 | 0.2080 | 0.1085 | 0.1026 | 0.1347 | 0.1453 | 0.3194 | 0.2080 | 0.0006 | 0.0055 | 0.0094 | 0.0303 | 0.1069 | 0.1416 | 0.1085 | 0.1344 | 0.4628 | 19 | 36 | 62 | 91 | 131 | 181 | 248 | 345 | 503 | 0.0039 | 114.79 | 6.970 | 0.2743 | 79040.1 | 42000000 | 26100000000 | 18000000000000 | 0.5116 | 0.1429 | 0.0379 | 0.0018 | 0.1569 | 0.0147 | 0.2288 | 0.0728 | 0.2157 | 0.1053 | 0.1542 | 0.1818 | 0.1085 | 0.2240 | 0.0549 | 0.1567 | 0.0275 | 0.1206 | 0.0157 | 0.1224 | 0.0011 | 0.0003 | 0.0022 | 0.0025 | 0.0037 | 0.0040 | 0.0145 | 0.0126 | 0.0764 | 0.0596 | 0.1135 | 0.1007 | 0.0827 | 0.0795 | 0.1228 | 0.1057 | 0.5829 | 0.6351 | 0.0010 | 0.0006 | 0.0031 | 0.0006 | 0.0078 | 0.0049 | 0.0259 | 0.0401 | 0.0953 | 0.1048 | 0.1472 | 0.1572 | 0.0969 | 0.1030 | 0.1358 | 0.1393 | 0.4870 | 0.4494 | 0.0004 | 0.0035 | 0.0031 | 0.0189 | 0.0817 | 0.1339 | 0.0935 | 0.1299 | 0.5351 | |||
MCF 10A | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 680 | 849 | 5669 | 11631 | 149.6 | 30.26 | 380.14 | 292.12 | 115 | 126 | 133 | 140 | 146 | 153 | 161 | 172 | 189 | 0.0978 | 1138 | 0.853 | 87.32 | 20.22 | 4 | 0.0376 | 213 | 0.0246 | 2.00 | 4.135 | 0.5882 | 23308.7 | 3780000 | 639000000 | 113000000000 | 0.4512 | 0.2143 | 0.0005 | 0.0000 | 0.0019 | 0.0004 | 0.0066 | 0.0006 | 0.0209 | 0.0047 | 0.0542 | 0.0190 | 0.1074 | 0.0594 | 0.1031 | 0.0456 | 0.1449 | 0.0760 | 0.5605 | 0.7945 | 0.0002 | 0.0000 | 0.0012 | 0.0002 | 0.0022 | 0.0005 | 0.0087 | 0.0041 | 0.0281 | 0.0148 | 0.0485 | 0.0422 | 0.0396 | 0.0185 | 0.0686 | 0.0351 | 0.8028 | 0.8846 | 0.0072 | 0.0165 | 0.0217 | 0.0535 | 0.0253 | 0.0535 | 0.0939 | 0.1934 | 0.1721 | 0.2058 | 0.1877 | 0.1934 | 0.1095 | 0.0864 | 0.1300 | 0.0947 | 0.2527 | 0.1029 | 0.0031 | 0.0043 | 0.0152 | 0.0390 | 0.0928 | 0.1383 | 0.1200 | 0.1380 | 0.4493 | 68 | 117 | 173 | 239 | 313 | 389 | 493 | 610 | 797 | 0.0026 | 36.91 | 6.778 | 0.2991 | 229829.0 | 180000000 | 166000000000 | 173000000000000 | 0.5041 | 0.1494 | 0.0174 | 0.0017 | 0.0886 | 0.0073 | 0.1781 | 0.0403 | 0.1658 | 0.0825 | 0.1856 | 0.1556 | 0.1451 | 0.1874 | 0.0933 | 0.1449 | 0.0612 | 0.1473 | 0.0650 | 0.2330 | 0.0002 | 0.0000 | 0.0023 | 0.0006 | 0.0058 | 0.0035 | 0.0167 | 0.0122 | 0.0657 | 0.0480 | 0.1189 | 0.0967 | 0.0796 | 0.0703 | 0.1194 | 0.1013 | 0.5913 | 0.6674 | 0.0015 | 0.0013 | 0.0036 | 0.0039 | 0.0103 | 0.0186 | 0.0328 | 0.0417 | 0.0904 | 0.1037 | 0.1420 | 0.1637 | 0.1030 | 0.1027 | 0.1258 | 0.1376 | 0.4904 | 0.4266 | 0.0006 | 0.0031 | 0.0121 | 0.0249 | 0.0804 | 0.1317 | 0.0936 | 0.1214 | 0.5321 | |
MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 646 | 621 | 554 | 3317 | 275.3 | 19.34 | 19.44 | 28.31 | 251 | 261 | 267 | 272 | 276 | 281 | 286 | 292 | 299 | 0.1007 | 334 | 0.832 | 128.55 | 29.97 | 1 | 0.5108 | 283 | 0.0078 | 11.20 | 5.111 | 0.3312 | 76161.1 | 21200000 | 5910000000 | 1660000000000 | 0.3922 | 0.2458 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0453 | 0.0451 | 0.0652 | 0.0650 | 0.0380 | 0.0307 | 0.0580 | 0.0469 | 0.7935 | 0.8123 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0453 | 0.0451 | 0.0652 | 0.0650 | 0.0380 | 0.0307 | 0.0580 | 0.0469 | 0.7935 | 0.8123 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0067 | 0.0100 | 0.0300 | 0.0533 | 0.0900 | 0.1667 | 0.1333 | 0.1567 | 0.3533 | 7 | 8 | 9 | 9 | 11 | 12 | 15 | 22 | 33 | 0.0979 | 0.55 | 1.508 | 0.4506 | 1178.9 | 161332 | 29100000 | 5860000000 | 0.5686 | 0.1153 | 0.0480 | 0.0687 | 0.1051 | 0.0634 | 0.1471 | 0.0569 | 0.1952 | 0.0838 | 0.2462 | 0.0967 | 0.1532 | 0.1267 | 0.0811 | 0.1590 | 0.0210 | 0.2105 | 0.0030 | 0.1343 | 0.0121 | 0.0433 | 0.0141 | 0.0377 | 0.0121 | 0.0314 | 0.0313 | 0.0328 | 0.0555 | 0.0370 | 0.0757 | 0.0656 | 0.0858 | 0.0628 | 0.1171 | 0.1172 | 0.5964 | 0.5722 | 0.0091 | 0.0139 | 0.0106 | 0.0239 | 0.0152 | 0.0359 | 0.0410 | 0.0478 | 0.0699 | 0.0896 | 0.1307 | 0.1116 | 0.1185 | 0.1116 | 0.1413 | 0.1434 | 0.4635 | 0.4223 | 0.0059 | 0.0059 | 0.0118 | 0.0403 | 0.0557 | 0.0853 | 0.0936 | 0.1256 | 0.5758 | |
Hs 578T | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 880 | 168 | 38955 | 26240 | 163.7 | 54.42 | 189.84 | 155.38 | 92 | 114 | 132 | 148 | 164 | 179 | 194 | 210 | 233 | 0.1215 | 3188 | 0.799 | 74.95 | 17.03 | 13 | 0.0043 | 168 | 0.0008 | 32.80 | 7.366 | 0.2060 | 29769.9 | 5880000 | 1240000000 | 280000000000 | 0.5763 | 0.1150 | 0.0010 | 0.0002 | 0.0035 | 0.0005 | 0.0154 | 0.0020 | 0.0472 | 0.0094 | 0.1113 | 0.0378 | 0.1741 | 0.0717 | 0.1653 | 0.0787 | 0.1782 | 0.1069 | 0.3041 | 0.6929 | 0.0003 | 0.0001 | 0.0009 | 0.0002 | 0.0030 | 0.0009 | 0.0108 | 0.0048 | 0.0303 | 0.0203 | 0.0519 | 0.0341 | 0.0512 | 0.0327 | 0.0704 | 0.0446 | 0.7812 | 0.8624 | 0.0018 | 0.0076 | 0.0072 | 0.0135 | 0.0124 | 0.0327 | 0.0413 | 0.0819 | 0.0859 | 0.1325 | 0.1267 | 0.1726 | 0.1108 | 0.1197 | 0.1380 | 0.1307 | 0.4759 | 0.3088 | 0.0012 | 0.0016 | 0.0058 | 0.0209 | 0.0477 | 0.0807 | 0.0801 | 0.1009 | 0.6610 | 30 | 51 | 77 | 110 | 148 | 191 | 245 | 316 | 419 | 0.0043 | 23.31 | 6.446 | 0.3390 | 60178.8 | 24700000 | 11900000000 | 6310000000000 | 0.6103 | 0.0987 | 0.0154 | 0.0035 | 0.0720 | 0.0118 | 0.1491 | 0.0312 | 0.1825 | 0.0787 | 0.1846 | 0.1419 | 0.1799 | 0.1989 | 0.0982 | 0.1547 | 0.0673 | 0.1582 | 0.0509 | 0.2210 | 0.0009 | 0.0008 | 0.0043 | 0.0023 | 0.0067 | 0.0044 | 0.0211 | 0.0165 | 0.0660 | 0.0589 | 0.1135 | 0.1002 | 0.0823 | 0.0792 | 0.1052 | 0.1029 | 0.6000 | 0.6347 | 0.0009 | 0.0028 | 0.0066 | 0.0068 | 0.0095 | 0.0154 | 0.0324 | 0.0388 | 0.0825 | 0.0887 | 0.1348 | 0.1364 | 0.0914 | 0.0993 | 0.1153 | 0.1173 | 0.5266 | 0.4944 | 0.0018 | 0.0040 | 0.0100 | 0.0258 | 0.0759 | 0.1202 | 0.0937 | 0.1112 | 0.5575 | |
MCF 10A | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 289 | 493 | 6798 | 23833 | 396.9 | 72.62 | 122.22 | 112.72 | 305 | 332 | 353 | 372 | 393 | 413 | 434 | 460 | 496 | 0.0457 | 1090 | 1.062 | 97.45 | 34.93 | 1 | 0.0374 | 254 | 0.0017 | 19.12 | 6.637 | 0.2476 | 162807.0 | 68900000 | 30000000000 | 13500000000000 | 0.3895 | 0.2520 | 0.0000 | 0.0000 | 0.0004 | 0.0002 | 0.0023 | 0.0005 | 0.0107 | 0.0006 | 0.0469 | 0.0131 | 0.0916 | 0.0269 | 0.1033 | 0.0220 | 0.1432 | 0.0346 | 0.6015 | 0.9022 | 0.0000 | 0.0000 | 0.0000 | 0.0001 | 0.0009 | 0.0003 | 0.0043 | 0.0003 | 0.0197 | 0.0111 | 0.0380 | 0.0209 | 0.0404 | 0.0105 | 0.0584 | 0.0164 | 0.8383 | 0.9404 | 0.0080 | 0.0227 | 0.0130 | 0.0455 | 0.0260 | 0.1136 | 0.0721 | 0.1212 | 0.1321 | 0.2045 | 0.1922 | 0.1515 | 0.1251 | 0.0985 | 0.1512 | 0.1061 | 0.2803 | 0.1364 | 0.0006 | 0.0018 | 0.0076 | 0.0223 | 0.0572 | 0.1036 | 0.0899 | 0.1253 | 0.5917 | 13 | 21 | 38 | 64 | 93 | 125 | 160 | 203 | 274 | 0.0273 | 9.30 | 5.190 | 0.4969 | 27642.2 | 8480000 | 3190000000 | 1400000000000 | 0.4768 | 0.1673 | 0.0272 | 0.0014 | 0.1103 | 0.0069 | 0.2030 | 0.0512 | 0.1793 | 0.1036 | 0.1586 | 0.1664 | 0.1277 | 0.1784 | 0.0836 | 0.1457 | 0.0699 | 0.1463 | 0.0404 | 0.2001 | 0.0004 | 0.0001 | 0.0012 | 0.0008 | 0.0030 | 0.0025 | 0.0136 | 0.0101 | 0.0526 | 0.0452 | 0.0989 | 0.0755 | 0.0730 | 0.0660 | 0.1124 | 0.0959 | 0.6447 | 0.7039 | 0.0012 | 0.0020 | 0.0031 | 0.0065 | 0.0092 | 0.0131 | 0.0290 | 0.0361 | 0.0788 | 0.0934 | 0.1280 | 0.1326 | 0.0965 | 0.1068 | 0.1320 | 0.1384 | 0.5220 | 0.4711 | 0.0005 | 0.0012 | 0.0038 | 0.0208 | 0.0676 | 0.1100 | 0.0939 | 0.1245 | 0.5777 | |
MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 218 | 312 | 2655 | 8245 | 132.8 | 44.21 | 178.73 | 118.36 | 91 | 99 | 108 | 117 | 125 | 134 | 142 | 155 | 176 | 0.0813 | 670 | 0.683 | 79.32 | 27.66 | 1 | 0.0968 | 257 | 0.0031 | 18.62 | 6.095 | 0.3246 | 19582.2 | 3340000 | 689000000 | 173000000000 | 0.4385 | 0.1979 | 0.0000 | 0.0000 | 0.0007 | 0.0000 | 0.0062 | 0.0004 | 0.0256 | 0.0020 | 0.0622 | 0.0283 | 0.1119 | 0.0557 | 0.1140 | 0.0414 | 0.1298 | 0.0602 | 0.5497 | 0.8120 | 0.0000 | 0.0000 | 0.0005 | 0.0000 | 0.0037 | 0.0004 | 0.0115 | 0.0015 | 0.0314 | 0.0216 | 0.0492 | 0.0352 | 0.0413 | 0.0250 | 0.0581 | 0.0367 | 0.8043 | 0.8796 | 0.0043 | 0.0000 | 0.0065 | 0.0100 | 0.0151 | 0.0100 | 0.0454 | 0.0350 | 0.1080 | 0.1100 | 0.1058 | 0.1600 | 0.0778 | 0.0750 | 0.1231 | 0.1350 | 0.5140 | 0.4650 | 0.0027 | 0.0018 | 0.0100 | 0.0255 | 0.0656 | 0.0974 | 0.0792 | 0.1193 | 0.5984 | 59 | 76 | 93 | 115 | 144 | 182 | 225 | 275 | 351 | 0.0020 | 52.90 | 6.928 | 0.2551 | 45949.6 | 15000000 | 5740000000 | 2430000000000 | 0.5074 | 0.1593 | 0.0155 | 0.0010 | 0.0882 | 0.0092 | 0.2007 | 0.0209 | 0.1771 | 0.0654 | 0.1630 | 0.1485 | 0.1441 | 0.1660 | 0.0774 | 0.1622 | 0.0566 | 0.1523 | 0.0774 | 0.2745 | 0.0005 | 0.0002 | 0.0027 | 0.0019 | 0.0060 | 0.0044 | 0.0169 | 0.0095 | 0.0638 | 0.0525 | 0.1051 | 0.0712 | 0.0744 | 0.0711 | 0.1097 | 0.0969 | 0.6210 | 0.6922 | 0.0011 | 0.0039 | 0.0068 | 0.0123 | 0.0139 | 0.0178 | 0.0444 | 0.0468 | 0.0889 | 0.0868 | 0.1213 | 0.1391 | 0.0998 | 0.1297 | 0.1348 | 0.1440 | 0.4889 | 0.4196 | 0.0009 | 0.0036 | 0.0083 | 0.0238 | 0.0753 | 0.1202 | 0.0940 | 0.1196 | 0.5542 | |||
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1018 | 411 | 2600 | 6088 | 103.7 | 24.69 | 101.32 | 87.25 | 73 | 84 | 90 | 96 | 102 | 108 | 114 | 122 | 135 | 0.1304 | 794 | 0.757 | 122.10 | 28.23 | 2 | 0.1200 | 312 | 0.0039 | 11.20 | 5.825 | 0.3318 | 11365.0 | 1320000 | 161000000 | 21000000000 | 0.5268 | 0.1497 | 0.0006 | 0.0000 | 0.0037 | 0.0004 | 0.0141 | 0.0012 | 0.0263 | 0.0050 | 0.0912 | 0.0308 | 0.1769 | 0.0791 | 0.1622 | 0.0579 | 0.1714 | 0.0991 | 0.3537 | 0.7265 | 0.0005 | 0.0000 | 0.0014 | 0.0004 | 0.0038 | 0.0008 | 0.0100 | 0.0031 | 0.0491 | 0.0212 | 0.0920 | 0.0586 | 0.0734 | 0.0358 | 0.0972 | 0.0657 | 0.6725 | 0.8144 | 0.0043 | 0.0071 | 0.0259 | 0.0496 | 0.0237 | 0.0567 | 0.1034 | 0.1064 | 0.1315 | 0.2199 | 0.1810 | 0.1348 | 0.1099 | 0.1277 | 0.1142 | 0.1064 | 0.3060 | 0.1915 | 0.0033 | 0.0033 | 0.0181 | 0.0280 | 0.0954 | 0.1151 | 0.1127 | 0.1332 | 0.4910 | 24 | 33 | 44 | 57 | 72 | 91 | 120 | 163 | 222 | 0.0127 | 11.75 | 5.310 | 0.4411 | 17878.5 | 4610000 | 1580000000 | 681000000000 | 0.5373 | 0.1316 | 0.0246 | 0.0041 | 0.1026 | 0.0157 | 0.2041 | 0.0508 | 0.1688 | 0.1015 | 0.1709 | 0.1614 | 0.1368 | 0.1756 | 0.0887 | 0.1558 | 0.0641 | 0.1355 | 0.0395 | 0.1995 | 0.0022 | 0.0020 | 0.0051 | 0.0055 | 0.0091 | 0.0086 | 0.0215 | 0.0204 | 0.0680 | 0.0540 | 0.1066 | 0.0870 | 0.0844 | 0.0804 | 0.1135 | 0.1042 | 0.5897 | 0.6380 | 0.0022 | 0.0013 | 0.0039 | 0.0053 | 0.0061 | 0.0112 | 0.0259 | 0.0258 | 0.0783 | 0.0998 | 0.1517 | 0.1685 | 0.0998 | 0.1005 | 0.1224 | 0.1375 | 0.5097 | 0.4501 | 0.0027 | 0.0032 | 0.0163 | 0.0195 | 0.0736 | 0.1290 | 0.0940 | 0.1154 | 0.5463 |