High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)

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Cell SM Name Small Mol Concentration Small Mol Conc Unit Other Reagent 1 Name Other Reagent 1 Detection Channel Other Reagent 2 Name Other Reagent 2 Detection Channel Row Column Field X-coordinate Y-coordinate Image Nuclear area (pixels) Cytoplasm area (pixels) Nuclear intensity (AU) Std Dev of nuclear intensity (AU) Cytoplasm intensity (AU) Std Dev of cytoplasm intensity (AU) 10% quantile of nuclear intensity (AU) 20% quantile of nuclear intensity (AU) 30% quantile of nuclear intensity (AU) 40% quantile of nuclear intensity (AU) 50% quantile of nuclear intensity (AU) 60% quantile of nuclear intensity (AU) 70% quantile of nuclear intensity (AU) 80% quantile of nuclear intensity (AU) 90% quantile of nuclear intensity (AU) Ratio of cytoplasm perimeter to area Cytoplasm perimeter (pixels) Nuclear roundness Nuclear length (pixels) Nuclear halfwidth (pixels) Number of nuclei Ratio of nuclear perimeter to area Nuclear perimeter (pixels) Nuclear Haralick ASM Nuclear Haralick contrast Nuclear Haralick entropy Nuclear Haralick IDM Nuclear Haralick moment 2 Nuclear Haralick moment 3 Nuclear Haralick moment 4 Nuclear Haralick moment 5 Nuclear radial moment (border) Nuclear radial moment (center) Nuclear Threshold Adj Stat 1 (Threshold: 0.2) Nuclear Threshold Adj Stat 1 (Threshold: 0.4) Nuclear Threshold Adj Stat 2 (Threshold: 0.2) Nuclear Threshold Adj Stat 2 (Threshold: 0.4) Nuclear Threshold Adj Stat 3 (Threshold: 0.2) Nuclear Threshold Adj Stat 3 (Threshold: 0.4) Nuclear Threshold Adj Stat 4 (Threshold: 0.2) Nuclear Threshold Adj Stat 4 (Threshold: 0.4) Nuclear Threshold Adj Stat 5 (Threshold: 0.2) Nuclear Threshold Adj Stat 5 (Threshold: 0.4) Nuclear Threshold Adj Stat 6 (Threshold: 0.2) Nuclear Threshold Adj Stat 6 (Threshold: 0.4) Nuclear Threshold Adj Stat 7 (Threshold: 0.2) Nuclear Threshold Adj Stat 7 (Threshold: 0.4) Nuclear Threshold Adj Stat 8 (Threshold: 0.2) Nuclear Threshold Adj Stat 8 (Threshold: 0.4) Nuclear Threshold Adj Stat 9 (Threshold: 0.2) Nuclear Threshold Adj Stat 9 (Threshold: 0.4) Nuclear Threshold Adj Stat 10 (Threshold: 0.2) Nuclear Threshold Adj Stat 10 (Threshold: 0.4) Nuclear Threshold Adj Stat 11 (Threshold: 0.2) Nuclear Threshold Adj Stat 11 (Threshold: 0.4) Nuclear Threshold Adj Stat 12 (Threshold: 0.2) Nuclear Threshold Adj Stat 12 (Threshold: 0.4) Nuclear Threshold Adj Stat 13 (Threshold: 0.2) Nuclear Threshold Adj Stat 13 (Threshold: 0.4) Nuclear Threshold Adj Stat 14 (Threshold: 0.2) Nuclear Threshold Adj Stat 14 (Threshold: 0.4) Nuclear Threshold Adj Stat 15 (Threshold: 0.2) Nuclear Threshold Adj Stat 15 (Threshold: 0.4) Nuclear Threshold Adj Stat 16 (Threshold: 0.2) Nuclear Threshold Adj Stat 16 (Threshold: 0.4) Nuclear Threshold Adj Stat 17 (Threshold: 0.2) Nuclear Threshold Adj Stat 17 (Threshold: 0.4) Nuclear Threshold Adj Stat 18 (Threshold: 0.2) Nuclear Threshold Adj Stat 18 (Threshold: 0.4) Nuclear Threshold Adj Stat 19 (Threshold: 0.2) Nuclear Threshold Adj Stat 19 (Threshold: 0.4) Nuclear Threshold Adj Stat 20 (Threshold: 0.2) Nuclear Threshold Adj Stat 20 (Threshold: 0.4) Nuclear Threshold Adj Stat 21 (Threshold: 0.2) Nuclear Threshold Adj Stat 21 (Threshold: 0.4) Nuclear Threshold Adj Stat 22 (Threshold: 0.2) Nuclear Threshold Adj Stat 22 (Threshold: 0.4) Nuclear Threshold Adj Stat 23 (Threshold: 0.2) Nuclear Threshold Adj Stat 23 (Threshold: 0.4) Nuclear Threshold Adj Stat 24 (Threshold: 0.2) Nuclear Threshold Adj Stat 24 (Threshold: 0.4) Nuclear Threshold Adj Stat 25 (Threshold: 0.2) Nuclear Threshold Adj Stat 25 (Threshold: 0.4) Nuclear Threshold Adj Stat 26 (Threshold: 0.2) Nuclear Threshold Adj Stat 26 (Threshold: 0.4) Nuclear Threshold Adj Stat 27 (Threshold: 0.2) Nuclear Threshold Adj Stat 27 (Threshold: 0.4) Nuclear Threshold Adj Stat 28 Nuclear Threshold Adj Stat 29 Nuclear Threshold Adj Stat 30 Nuclear Threshold Adj Stat 31 Nuclear Threshold Adj Stat 32 Nuclear Threshold Adj Stat 33 Nuclear Threshold Adj Stat 34 Nuclear Threshold Adj Stat 35 Nuclear Threshold Adj Stat 36 10% quantile of cytoplasm intensity (AU) 20% quantile of cytoplasm intensity (AU) 30% quantile of cytoplasm intensity (AU) 40% quantile of cytoplasm intensity (AU) 50% quantile of cytoplasm intensity (AU) 60% quantile of cytoplasm intensity (AU) 70% quantile of cytoplasm intensity (AU) 80% quantile of cytoplasm intensity (AU) 90% quantile of cytoplasm intensity (AU) Cytoplasmic Haralick ASM Cytoplasmic Haralick contrast Cytoplasmic Haralick entropy Cytoplasmic Haralick IDM Cytoplasmic Haralick moment 2 Cytoplasmic Haralick moment 3 Cytoplasmic Haralick moment 4 Cytoplasmic Haralick moment 5 Cytoplasmic radial moment (border) Cytoplasmic radial moment (center) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 28 Cytoplasmic Threshold Adj Stat 29 Cytoplasmic Threshold Adj Stat 30 Cytoplasmic Threshold Adj Stat 31 Cytoplasmic Threshold Adj Stat 32 Cytoplasmic Threshold Adj Stat 33 Cytoplasmic Threshold Adj Stat 34 Cytoplasmic Threshold Adj Stat 35 Cytoplasmic Threshold Adj Stat 36
SK-BR-3 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 897 352 image if available 491 10165 31.2 10.66 5.57 2.04 21 23 24 26 27 30 34 40 49 0.0858 872 0.813 87.21 20.59 5 0.4073 200 0.0618 0.76 3.150 0.6872 1083.9
42132.6
1810000
83600000
0.3481 0.2731 0.0093 0.0000 0.0093 0.0000 0.0187 0.0025 0.0561 0.0150 0.1168 0.0848 0.2336 0.0798 0.1963 0.0873 0.1869 0.1446 0.1729 0.5860 0.0061 0.0000 0.0061 0.0000 0.0122 0.0021 0.0334 0.0125 0.0608 0.0582 0.0912 0.0353 0.0821 0.0561 0.1003 0.0811 0.6079 0.7547 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0348 0.0625 0.0609 0.0500 0.1391 0.1625 0.0609 0.1125 0.1043 0.0750 0.6000 0.5375 0.0000 0.0107 0.0000 0.0481 0.0428 0.1070 0.0695 0.1016 0.6203 3 4 4 5 5 6 7 7 8 0.0061 0.11 0.381 0.0699 35.2
247.481
1925.98
16644.2
0.5163 0.1494 0.0075 0.0004 0.0317 0.0014 0.1096 0.0083 0.1889 0.0233 0.2557 0.0515 0.2310 0.1180 0.1247 0.2326 0.0447 0.3477 0.0060 0.2168 0.0016 0.0000 0.0075 0.0002 0.0348 0.0045 0.0908 0.0154 0.1571 0.0325 0.2323 0.0692 0.2275 0.1499 0.1597 0.3269 0.0887 0.4014 0.2469 0.4372 0.2984 0.2271 0.1850 0.0804 0.0888 0.0635 0.0564 0.0536 0.0355 0.0409 0.0392 0.0381 0.0282 0.0381 0.0214 0.0212 0.0197 0.0760 0.1532 0.2101 0.1844 0.1602 0.1001 0.0600 0.0363
SK-BR-3 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 424 598 image if available 10118 27401 44.6 15.32 9.66 10.14 26 30 34 39 43 46 51 58 68 0.0697 1910 0.653 52.00 10.05 2 0.0153 155 0.0320 0.80 3.734 0.7116 2220.7
121956
7260000
460000000
0.4370 0.1928 0.0033 0.0009 0.0117 0.0021 0.0212 0.0062 0.0405 0.0162 0.0660 0.0337 0.0944 0.0462 0.1215 0.0617 0.1775 0.0854 0.4639 0.7475 0.0012 0.0004 0.0041 0.0011 0.0082 0.0029 0.0150 0.0080 0.0223 0.0197 0.0297 0.0256 0.0429 0.0335 0.0634 0.0478 0.8132 0.8611 0.0054 0.0041 0.0122 0.0117 0.0168 0.0233 0.0337 0.0425 0.0471 0.0487 0.0631 0.0720 0.0608 0.0822 0.0838 0.0864 0.6771 0.6292 0.0039 0.0100 0.0142 0.0234 0.0345 0.0395 0.0542 0.0860 0.7342 4 5 6 7 7 8 9 11 16 0.0607 0.27 1.084 0.3393 196.2
10715.8
1130000
163000000
0.5653 0.1216 0.0777 0.0043 0.1202 0.0147 0.1403 0.0416 0.1602 0.0819 0.1662 0.1200 0.1599 0.1529 0.1160 0.1781 0.0486 0.2087 0.0109 0.1979 0.0433 0.0019 0.0675 0.0095 0.0728 0.0304 0.0744 0.0626 0.0830 0.0967 0.0877 0.1232 0.0996 0.1307 0.1151 0.1503 0.3566 0.3946 0.0629 0.0327 0.0480 0.0262 0.0487 0.0276 0.0411 0.0316 0.0533 0.0584 0.0696 0.0784 0.0791 0.0835 0.1064 0.1232 0.4909 0.5384 0.0684 0.0635 0.0650 0.0662 0.0726 0.0769 0.0668 0.0896 0.4311
SK-BR-3 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 684 361 image if available 399 6206 58.4 9.74 24.73 66.86 46 49 52 54 57 61 64 69 72 0.1017 631 0.682 36.24 8.54 1 0.2607 104 0.0248 2.23 3.908 0.5277 3503.6
215851
13600000
881000000
0.3536 0.2676 0.0000 0.0000 0.0035 0.0000 0.0071 0.0000 0.0426 0.0101 0.0922 0.0628 0.1525 0.0678 0.1489 0.0653 0.1915 0.0879 0.3617 0.7060 0.0000 0.0000 0.0000 0.0000 0.0028 0.0000 0.0225 0.0100 0.0535 0.0627 0.0817 0.0677 0.0789 0.0652 0.1042 0.0677 0.6563 0.7268 0.0137 1.0000 0.0000 0.0000 0.0274 0.0000 0.0822 0.0000 0.0822 0.0000 0.1781 0.0000 0.1370 0.0000 0.2055 0.0000 0.2740 0.0000 0.0053 0.0053 0.0159 0.0265 0.0635 0.1111 0.1058 0.0899 0.5767 5 6 7 8 9 10 13 18 40 0.3348 9.79 2.064 0.7707 5081.6
2730000
1940000000
1570000000000
0.6341 0.0846 0.0349 0.0330 0.1163 0.0366 0.1453 0.0425 0.1628 0.0837 0.2006 0.1262 0.1919 0.1498 0.1163 0.1462 0.0233 0.1686 0.0087 0.2134 0.0053 0.0181 0.0079 0.0194 0.0184 0.0148 0.0202 0.0258 0.0746 0.0523 0.0886 0.0690 0.0912 0.0800 0.1202 0.1052 0.5737 0.6155 0.0025 0.0028 0.0013 0.0000 0.0088 0.0043 0.0251 0.0256 0.0842 0.0954 0.1256 0.1439 0.0942 0.1068 0.1344 0.1296 0.5239 0.4915 0.0022 0.0098 0.0065 0.0271 0.0869 0.0912 0.0988 0.1325 0.5451
SK-BR-3 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 1275 136 image if available 348 1761 24.9 4.56 12.04 4.73 19 21 22 24 25 26 27 29 31 0.1550 273 0.753 89.14 19.31 1 0.6466 225 0.0917 1.19 2.649 0.6279 641.9
17045.4
465908
13100000
0.3990 0.2249 0.0000 0.0000 0.0040 0.0000 0.0283 0.0000 0.0850 0.0208 0.1377 0.0564 0.1903 0.0682 0.2510 0.0653 0.1984 0.1721 0.1053 0.6172 0.0000 0.0000 0.0000 0.0000 0.0097 0.0000 0.0355 0.0145 0.0548 0.0609 0.0613 0.0522 0.0968 0.0551 0.2194 0.0725 0.5226 0.7449 0.0476 0.6250 0.1746 0.2500 0.1270 0.1250 0.2857 0.0000 0.1746 0.0000 0.1111 0.0000 0.0794 0.0000 0.0000 0.0000 0.0000 0.0000 0.0056 0.0278 0.0778 0.0889 0.1611 0.2111 0.2000 0.1722 0.0556 7 7 9 11 11 13 14 16 18 0.4459 0.26 0.850 0.7731 167.2
2583.98
43505.2
785905
0.4996 0.1549 0.0715 0.0083 0.1464 0.0379 0.2230 0.0592 0.2379 0.0981 0.1747 0.1637 0.0948 0.2202 0.0349 0.2239 0.0166 0.1508 0.0000 0.0379 0.0196 0.0065 0.0267 0.0196 0.0364 0.0224 0.0756 0.0427 0.0907 0.0782 0.1307 0.0941 0.1627 0.1260 0.1956 0.2288 0.2622 0.3816 0.0611 0.1433 0.0630 0.1533 0.1183 0.2067 0.1756 0.1600 0.1584 0.1267 0.1737 0.1000 0.1317 0.0667 0.0954 0.0333 0.0229 0.0100 0.0427 0.0380 0.0617 0.1032 0.1329 0.1696 0.1459 0.1969 0.1091
SK-BR-3 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 1053 104 image if available 2330 7315 404.0 189.76 84.83 144.30 168 214 264 314 375 453 527 592 678 0.0932 682 0.598 100.02 13.89 5 0.0927 216 0.0009 43.35 7.214 0.1661 199239.0
112000000
68300000000
44000000000000
0.3454 0.2664 0.0000 0.0000 0.0000 0.0000 0.0079 0.0000 0.0317 0.0172 0.1329 0.0499 0.2341 0.0946 0.2004 0.0851 0.1786 0.0997 0.2143 0.6535 0.0000 0.0000 0.0000 0.0000 0.0007 0.0000 0.0060 0.0052 0.0268 0.0215 0.0357 0.0302 0.0402 0.0279 0.0462 0.0296 0.8444 0.8857 0.0000 0.0000 0.0000 0.0018 0.0024 0.0000 0.0060 0.0107 0.0441 0.0661 0.0691 0.0946 0.0524 0.0643 0.0799 0.1143 0.7461 0.6482 0.0000 0.0000 0.0000 0.0037 0.0399 0.0463 0.0399 0.0704 0.7998 21 27 31 34 38 44 54 94 219 0.1318 7.03 3.250 0.7401 28015.3
26600000
42300000000
80500000000000
0.5119 0.1569 0.0219 0.0200 0.0820 0.0234 0.1530 0.0443 0.1995 0.0747 0.2158 0.1354 0.1503 0.1458 0.0956 0.1519 0.0601 0.1632 0.0219 0.2413 0.0028 0.0096 0.0062 0.0104 0.0068 0.0183 0.0186 0.0246 0.0361 0.0445 0.0559 0.0512 0.0514 0.0608 0.0745 0.0908 0.7477 0.6898 0.0000 0.0000 0.0014 0.0032 0.0057 0.0064 0.0135 0.0216 0.0519 0.0632 0.0811 0.0800 0.0597 0.0752 0.0989 0.0992 0.6878 0.6512 0.0000 0.0000 0.0052 0.0181 0.0413 0.0664 0.0529 0.0896 0.7266
SK-BR-3 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 524 311 image if available 7833 16316 159.4 129.05 84.65 174.06 65 76 86 97 114 131 150 185 382 0.0834 1360 1.188 60.96 23.71 5 0.0200 157 0.0057 7.18 5.903 0.4831 42052.4
16100000
7440000000
3750000000000
0.4134 0.2024 0.0022 0.0044 0.0039 0.0032 0.0061 0.0041 0.0335 0.0116 0.0754 0.0367 0.0972 0.0576 0.0972 0.0547 0.1056 0.0789 0.5788 0.7488 0.0012 0.0031 0.0021 0.0023 0.0027 0.0029 0.0140 0.0079 0.0273 0.0211 0.0334 0.0280 0.0404 0.0320 0.0507 0.0445 0.8282 0.8580 0.0007 0.0000 0.0007 0.0000 0.0033 0.0000 0.0086 0.0022 0.0213 0.0230 0.0452 0.0445 0.0219 0.0208 0.0359 0.0408 0.8625 0.8687 0.0005 0.0039 0.0043 0.0096 0.0294 0.0487 0.0352 0.0545 0.8140 8 10 12 15 18 24 39 87 242 0.1992 8.64 2.988 0.7068 37461.6
26400000
22100000000
20600000000000
0.5330 0.1352 0.0090 0.0029 0.0336 0.0070 0.0493 0.0187 0.1087 0.0531 0.1659 0.0904 0.1839 0.1376 0.1390 0.1405 0.1312 0.1359 0.1794 0.4140 0.0005 0.0009 0.0029 0.0023 0.0029 0.0042 0.0098 0.0168 0.0383 0.0349 0.0554 0.0519 0.0449 0.0496 0.0660 0.0575 0.7794 0.7817 0.0021 0.0004 0.0017 0.0035 0.0045 0.0047 0.0141 0.0116 0.0497 0.0520 0.0783 0.0849 0.0583 0.0621 0.0852 0.0791 0.7060 0.7017 0.0009 0.0033 0.0045 0.0117 0.0415 0.0667 0.0505 0.0739 0.7471
SK-BR-3 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 382 482 image if available 6733 6438 43.2 12.21 112.41 165.59 28 32 35 39 42 46 50 54 60 0.1785 1149 1.039 54.34 16.16 3 0.0192 129 0.0360 0.84 3.592 0.6983 2014.6
100311
5270000
290000000
0.3887 0.2344 0.0060 0.0014 0.0139 0.0039 0.0220 0.0043 0.0460 0.0107 0.0794 0.0318 0.1389 0.0469 0.1480 0.0529 0.1880 0.0959 0.3578 0.7522 0.0027 0.0005 0.0041 0.0010 0.0078 0.0010 0.0188 0.0052 0.0347 0.0229 0.0580 0.0316 0.0586 0.0321 0.0858 0.0495 0.7295 0.8563 0.0070 0.0313 0.0186 0.0224 0.0256 0.0328 0.0413 0.0627 0.0721 0.0687 0.0809 0.1224 0.0878 0.1328 0.1268 0.1597 0.5398 0.3672 0.0033 0.0090 0.0189 0.0269 0.0452 0.0619 0.0736 0.0984 0.6628 7 8 10 12 19 48 124 221 345 0.0718 6.66 3.779 0.5031 40050.5
19600000
11300000000
7260000000000
0.4549 0.1859 0.0359 0.0046 0.1257 0.0170 0.2036 0.0880 0.1916 0.1173 0.1796 0.1867 0.1168 0.1929 0.0778 0.1312 0.0539 0.1281 0.0150 0.1343 0.0005 0.0008 0.0014 0.0021 0.0023 0.0008 0.0087 0.0068 0.0407 0.0343 0.0535 0.0525 0.0512 0.0423 0.0699 0.0728 0.7719 0.7875 0.0005 0.0000 0.0000 0.0012 0.0022 0.0041 0.0097 0.0146 0.0529 0.0578 0.0707 0.0776 0.0723 0.0712 0.0960 0.0968 0.6958 0.6768 0.0000 0.0010 0.0035 0.0144 0.0416 0.0575 0.0615 0.0878 0.7328
SK-BR-3 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 1130 267 image if available 5490 23038 164.0 66.56 28.31 61.33 83 103 121 140 156 173 190 215 271 0.0512 1180 0.983 61.59 20.03 5 0.0288 158 0.0023 6.37 6.316 0.3881 31316.4
6760000
1600000000
408000000000
0.3733 0.2534 0.0000 0.0000 0.0019 0.0025 0.0077 0.0028 0.0178 0.0083 0.0548 0.0230 0.0836 0.0418 0.1000 0.0452 0.1629 0.0593 0.5714 0.8171 0.0000 0.0000 0.0011 0.0015 0.0023 0.0018 0.0056 0.0051 0.0158 0.0124 0.0237 0.0218 0.0259 0.0218 0.0440 0.0294 0.8816 0.9062 0.0027 0.0011 0.0075 0.0054 0.0137 0.0087 0.0239 0.0130 0.0321 0.0369 0.0498 0.0510 0.0546 0.0304 0.0539 0.0542 0.7618 0.7993 0.0000 0.0012 0.0056 0.0164 0.0308 0.0504 0.0496 0.0712 0.7747 7 9 10 12 13 15 18 25 46 0.1947 4.25 2.622 0.7761 4562.8
1730000
803000000
408000000000
0.5689 0.1210 0.0523 0.0587 0.0562 0.0581 0.0812 0.0637 0.1251 0.0665 0.1413 0.0729 0.1613 0.0863 0.1935 0.0999 0.1268 0.1500 0.0623 0.3441 0.0140 0.0361 0.0138 0.0353 0.0177 0.0353 0.0272 0.0346 0.0400 0.0414 0.0560 0.0533 0.0641 0.0585 0.0971 0.0880 0.6701 0.6175 0.0057 0.0047 0.0093 0.0061 0.0131 0.0140 0.0191 0.0201 0.0508 0.0635 0.0669 0.0793 0.0770 0.0840 0.1123 0.1231 0.6459 0.6053 0.0104 0.0106 0.0164 0.0205 0.0425 0.0614 0.0594 0.1068 0.6718
SK-BR-3 A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 961 83 image if available 2742 10295 256.4 210.99 5.84 2.73 85 107 125 146 174 205 260 375 620 0.0768 791 0.892 36.22 8.60 0 0.0317 87 0.0014 48.21 6.944 0.2535 110231.0
65700000
45700000000
34200000000000
0.3023 0.3121 0.0000 0.0000 0.0068 0.0000 0.0091 0.0000 0.0590 0.0149 0.1791 0.0528 0.1655 0.0916 0.1179 0.0677 0.1088 0.1066 0.3537 0.6663 0.0000 0.0000 0.0027 0.0000 0.0000 0.0000 0.0072 0.0076 0.0370 0.0242 0.0497 0.0369 0.0416 0.0242 0.0542 0.0445 0.8076 0.8626 0.0015 0.0000 0.0000 0.0000 0.0015 0.0000 0.0075 0.0070 0.0330 0.0370 0.0526 0.0546 0.0330 0.0352 0.0691 0.0651 0.8018 0.8011 0.0012 0.0012 0.0000 0.0059 0.0297 0.0547 0.0321 0.0523 0.8228 2 4 4 5 6 6 7 8 9 0.0175 13.89 4.460 0.2950 41.5
339.783
3128.09
31961.6
0.5476 0.1416 0.0210 0.0022 0.0924 0.0062 0.1853 0.0333 0.2319 0.0823 0.2233 0.1544 0.1561 0.2425 0.0700 0.2497 0.0170 0.1701 0.0030 0.0593 0.0012 0.0000 0.0080 0.0010 0.0371 0.0068 0.0981 0.0266 0.1836 0.0573 0.2370 0.1201 0.2176 0.2178 0.1428 0.3119 0.0746 0.2586 0.1311 0.2667 0.2100 0.2515 0.2092 0.1673 0.1698 0.1115 0.1054 0.0630 0.0671 0.0527 0.0519 0.0333 0.0371 0.0339 0.0183 0.0200 0.0124 0.0502 0.1000 0.1483 0.1892 0.1839 0.1558 0.0989 0.0613
SK-BR-3 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 770 194 image if available 4106 14842 217.4 110.14 102.63 168.85 87 104 124 149 193 255 309 338 368 0.0595 883 0.734 130.10 25.02 4 0.0774 318 0.0016 20.13 6.862 0.2708 59394.7
18600000
6250000000
2190000000000
0.3003 0.3143 0.0017 0.0020 0.0017 0.0047 0.0050 0.0027 0.0199 0.0182 0.1393 0.0532 0.2703 0.1097 0.1294 0.0787 0.1592 0.1016 0.2736 0.6292 0.0000 0.0004 0.0000 0.0011 0.0005 0.0007 0.0014 0.0043 0.0199 0.0180 0.0398 0.0371 0.0172 0.0213 0.0330 0.0317 0.8883 0.8853 0.0000 0.0000 0.0000 0.0023 0.0019 0.0023 0.0025 0.0070 0.0243 0.0319 0.0473 0.0474 0.0230 0.0365 0.0398 0.0629 0.8613 0.8096 0.0000 0.0000 0.0010 0.0047 0.0210 0.0367 0.0257 0.0352 0.8756 12 15 18 23 35 53 82 137 279 0.0621 16.73 4.450 0.6158 39039.8
25800000
21500000000
20400000000000
0.5806 0.1178 0.0142 0.0012 0.0745 0.0050 0.1347 0.0255 0.1665 0.0751 0.1808 0.1211 0.1548 0.1645 0.1163 0.1413 0.0879 0.1463 0.0703 0.3200 0.0004 0.0002 0.0022 0.0006 0.0034 0.0017 0.0117 0.0140 0.0549 0.0436 0.0904 0.0624 0.0616 0.0618 0.0940 0.0822 0.6814 0.7336 0.0000 0.0000 0.0015 0.0028 0.0065 0.0070 0.0175 0.0228 0.0713 0.0831 0.1208 0.1189 0.0799 0.0856 0.1097 0.1140 0.5927 0.5658 0.0008 0.0024 0.0040 0.0129 0.0630 0.1018 0.0691 0.1036 0.6424
SK-BR-3 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 1108 239 image if available 5108 12529 286.7 70.87 214.74 352.40 171 236 266 284 299 315 328 344 365 0.0797 998 0.558 111.13 15.52 4 0.0484 247 0.0020 16.33 6.555 0.2615 87243.0
27600000
9000000000
3000000000000
0.3894 0.2353 0.0003 0.0000 0.0013 0.0000 0.0025 0.0004 0.0143 0.0011 0.0584 0.0180 0.0901 0.0332 0.0841 0.0276 0.1336 0.0427 0.6155 0.8769 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0005 0.0007 0.0180 0.0141 0.0245 0.0255 0.0159 0.0137 0.0327 0.0196 0.9084 0.9264 0.0060 0.0200 0.0109 0.1000 0.0268 0.1400 0.0625 0.1500 0.1240 0.1900 0.1488 0.1800 0.1399 0.1200 0.1290 0.0700 0.3522 0.0300 0.0013 0.0007 0.0040 0.0131 0.0368 0.0646 0.0703 0.1078 0.7014 8 10 13 17 22 32 138 460 810 0.1100 11.85 3.914 0.5579 170291.0
167000000
181000000000
211000000000000
0.5996 0.0926 0.0347 0.0084 0.1262 0.0139 0.2429 0.0446 0.1767 0.0990 0.2019 0.1660 0.1703 0.2106 0.0315 0.1381 0.0126 0.1367 0.0032 0.1827 0.0006 0.0000 0.0006 0.0000 0.0014 0.0003 0.0037 0.0024 0.0292 0.0286 0.0404 0.0329 0.0388 0.0347 0.0584 0.0583 0.8270 0.8428 0.0000 0.0006 0.0000 0.0010 0.0012 0.0003 0.0040 0.0055 0.0339 0.0372 0.0456 0.0486 0.0395 0.0466 0.0688 0.0696 0.8070 0.7905 0.0000 0.0000 0.0006 0.0038 0.0337 0.0391 0.0399 0.0609 0.8219
SK-BR-3 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 913 210 image if available 8143 27204 304.1 75.81 255.15 302.47 195 245 273 292 310 328 348 371 396 0.0396 1076 1.114 110.82 43.01 5 0.0373 304 0.0010 29.98 7.166 0.2157 98209.8
33200000
11600000000
4170000000000
0.4037 0.2325 0.0006 0.0000 0.0017 0.0000 0.0087 0.0001 0.0205 0.0021 0.0499 0.0164 0.0838 0.0287 0.0889 0.0302 0.1235 0.0508 0.6224 0.8717 0.0000 0.0000 0.0002 0.0000 0.0011 0.0000 0.0037 0.0011 0.0125 0.0105 0.0220 0.0168 0.0235 0.0118 0.0341 0.0168 0.9030 0.9431 0.0027 0.0366 0.0038 0.0549 0.0215 0.0623 0.0447 0.1282 0.0910 0.2051 0.1319 0.1722 0.1179 0.1612 0.1524 0.0989 0.4340 0.0806 0.0014 0.0032 0.0069 0.0123 0.0407 0.0638 0.0782 0.0981 0.6954 11 17 29 55 110 207 346 511 718 0.0322 37.90 6.066 0.4425 156585.0
127000000
124000000000
141000000000000
0.4560 0.1894 0.0158 0.0005 0.0981 0.0072 0.2220 0.0341 0.1823 0.1004 0.1923 0.1873 0.1306 0.2205 0.0775 0.1404 0.0464 0.1380 0.0349 0.1716 0.0002 0.0001 0.0006 0.0008 0.0034 0.0020 0.0077 0.0080 0.0389 0.0364 0.0615 0.0565 0.0439 0.0435 0.0653 0.0602 0.7784 0.7924 0.0005 0.0004 0.0011 0.0013 0.0019 0.0025 0.0109 0.0122 0.0412 0.0488 0.0778 0.0819 0.0567 0.0645 0.0835 0.0869 0.7263 0.7017 0.0003 0.0012 0.0026 0.0088 0.0373 0.0681 0.0507 0.0713 0.7596
SK-BR-3 A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 1017 554 image if available 378 9755 70.8 9.18 6.27 2.35 58 62 65 69 72 74 76 79 82 0.0685 668 1.025 80.23 26.63 2 0.5556 210 0.0307 2.20 3.799 0.5317 5100.6
373029
27700000
2080000000
0.3766 0.2528 0.0000 0.0000 0.0000 0.0000 0.0060 0.0000 0.0121 0.0053 0.0725 0.0556 0.0816 0.0635 0.0816 0.0503 0.1178 0.0688 0.6284 0.7566 0.0000 0.0000 0.0000 0.0000 0.0058 0.0000 0.0116 0.0053 0.0607 0.0556 0.0665 0.0635 0.0520 0.0503 0.0838 0.0688 0.7197 0.7566 0.0667 0.0000 0.0000 0.0000 0.0667 0.0000 0.2667 0.0000 0.0000 0.0000 0.2667 0.0000 0.2000 0.0000 0.0000 0.0000 0.1333 0.0000 0.0000 0.0093 0.0139 0.0324 0.0694 0.0787 0.0972 0.1481 0.5509 4 4 5 5 6 7 7 8 9 0.2315 0.45 1.048 0.5873 44.8
356.698
3133.82
30121.9
0.5230 0.1563 0.0095 0.0016 0.0423 0.0054 0.1159 0.0156 0.1913 0.0399 0.2491 0.0756 0.2068 0.1496 0.1260 0.2580 0.0507 0.3008 0.0085 0.1535 0.0009 0.0000 0.0033 0.0003 0.0157 0.0022 0.0417 0.0102 0.0896 0.0267 0.1561 0.0434 0.2071 0.1072 0.2316 0.2692 0.2540 0.5409 0.0990 0.1881 0.1831 0.2085 0.1795 0.1599 0.1502 0.1178 0.1272 0.0944 0.0980 0.0655 0.0618 0.0505 0.0512 0.0589 0.0501 0.0565 0.0080 0.0313 0.0735 0.1349 0.1725 0.1695 0.1459 0.1396 0.1248
SK-BR-3
0
DRAQ5 1 TMRE 2 2 2 1 949 628 image if available 5444 5921 503.2 113.35 118.69 220.33 340 443 485 510 528 546 564 585 614 0.1099 651 1.294 20.22 8.60 1 0.0103 56 0.0029 17.80 6.312 0.3065 266047.0
145000000
80700000000
45600000000000
0.4084 0.2255 0.0003 0.0000 0.0008 0.0000 0.0026 0.0002 0.0074 0.0008 0.0372 0.0133 0.0597 0.0230 0.0638 0.0153 0.1089 0.0266 0.7193 0.9208 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0006 0.0004 0.0158 0.0130 0.0270 0.0200 0.0203 0.0120 0.0363 0.0200 0.8999 0.9346 0.0097 0.0000 0.0110 0.0789 0.0331 0.1579 0.0607 0.0789 0.1062 0.1842 0.1407 0.1053 0.1407 0.0789 0.1434 0.2105 0.3545 0.1053 0.0000 0.0009 0.0035 0.0087 0.0363 0.0603 0.0609 0.0873 0.7421 7 10 14 19 25 37 74 153 375 0.0775 22.34 4.056 0.5583 62626.7
51300000
50500000000
55700000000000
0.5274 0.1314 0.0603 0.0015 0.2190 0.0164 0.3175 0.0848 0.1429 0.1711 0.1524 0.2321 0.0603 0.2292 0.0222 0.1295 0.0159 0.0744 0.0095 0.0610 0.0013 0.0006 0.0051 0.0011 0.0019 0.0033 0.0103 0.0094 0.0994 0.0833 0.1186 0.1127 0.0962 0.0944 0.1237 0.1133 0.5436 0.5819 0.0000 0.0009 0.0016 0.0009 0.0072 0.0071 0.0177 0.0301 0.1157 0.1125 0.1301 0.1364 0.1028 0.0912 0.1205 0.1355 0.5044 0.4854 0.0007 0.0007 0.0036 0.0144 0.1114 0.1222 0.0978 0.1258 0.5234