High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)

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Cell SM Name Small Mol Concentration Small Mol Conc Unit Other Reagent 1 Name Other Reagent 1 Detection Channel Other Reagent 2 Name Other Reagent 2 Detection Channel Row Column Field X-coordinate Y-coordinate Image Nuclear area (pixels) Cytoplasm area (pixels) Nuclear intensity (AU) Std Dev of nuclear intensity (AU) Cytoplasm intensity (AU) Std Dev of cytoplasm intensity (AU) 10% quantile of nuclear intensity (AU) 20% quantile of nuclear intensity (AU) 30% quantile of nuclear intensity (AU) 40% quantile of nuclear intensity (AU) 50% quantile of nuclear intensity (AU) 60% quantile of nuclear intensity (AU) 70% quantile of nuclear intensity (AU) 80% quantile of nuclear intensity (AU) 90% quantile of nuclear intensity (AU) Ratio of cytoplasm perimeter to area Cytoplasm perimeter (pixels) Nuclear roundness Nuclear length (pixels) Nuclear halfwidth (pixels) Number of nuclei Ratio of nuclear perimeter to area Nuclear perimeter (pixels) Nuclear Haralick ASM Nuclear Haralick contrast Nuclear Haralick entropy Nuclear Haralick IDM Nuclear Haralick moment 2 Nuclear Haralick moment 3 Nuclear Haralick moment 4 Nuclear Haralick moment 5 Nuclear radial moment (border) Nuclear radial moment (center) Nuclear Threshold Adj Stat 1 (Threshold: 0.2) Nuclear Threshold Adj Stat 1 (Threshold: 0.4) Nuclear Threshold Adj Stat 2 (Threshold: 0.2) Nuclear Threshold Adj Stat 2 (Threshold: 0.4) Nuclear Threshold Adj Stat 3 (Threshold: 0.2) Nuclear Threshold Adj Stat 3 (Threshold: 0.4) Nuclear Threshold Adj Stat 4 (Threshold: 0.2) Nuclear Threshold Adj Stat 4 (Threshold: 0.4) Nuclear Threshold Adj Stat 5 (Threshold: 0.2) Nuclear Threshold Adj Stat 5 (Threshold: 0.4) Nuclear Threshold Adj Stat 6 (Threshold: 0.2) Nuclear Threshold Adj Stat 6 (Threshold: 0.4) Nuclear Threshold Adj Stat 7 (Threshold: 0.2) Nuclear Threshold Adj Stat 7 (Threshold: 0.4) Nuclear Threshold Adj Stat 8 (Threshold: 0.2) Nuclear Threshold Adj Stat 8 (Threshold: 0.4) Nuclear Threshold Adj Stat 9 (Threshold: 0.2) Nuclear Threshold Adj Stat 9 (Threshold: 0.4) Nuclear Threshold Adj Stat 10 (Threshold: 0.2) Nuclear Threshold Adj Stat 10 (Threshold: 0.4) Nuclear Threshold Adj Stat 11 (Threshold: 0.2) Nuclear Threshold Adj Stat 11 (Threshold: 0.4) Nuclear Threshold Adj Stat 12 (Threshold: 0.2) Nuclear Threshold Adj Stat 12 (Threshold: 0.4) Nuclear Threshold Adj Stat 13 (Threshold: 0.2) Nuclear Threshold Adj Stat 13 (Threshold: 0.4) Nuclear Threshold Adj Stat 14 (Threshold: 0.2) Nuclear Threshold Adj Stat 14 (Threshold: 0.4) Nuclear Threshold Adj Stat 15 (Threshold: 0.2) Nuclear Threshold Adj Stat 15 (Threshold: 0.4) Nuclear Threshold Adj Stat 16 (Threshold: 0.2) Nuclear Threshold Adj Stat 16 (Threshold: 0.4) Nuclear Threshold Adj Stat 17 (Threshold: 0.2) Nuclear Threshold Adj Stat 17 (Threshold: 0.4) Nuclear Threshold Adj Stat 18 (Threshold: 0.2) Nuclear Threshold Adj Stat 18 (Threshold: 0.4) Nuclear Threshold Adj Stat 19 (Threshold: 0.2) Nuclear Threshold Adj Stat 19 (Threshold: 0.4) Nuclear Threshold Adj Stat 20 (Threshold: 0.2) Nuclear Threshold Adj Stat 20 (Threshold: 0.4) Nuclear Threshold Adj Stat 21 (Threshold: 0.2) Nuclear Threshold Adj Stat 21 (Threshold: 0.4) Nuclear Threshold Adj Stat 22 (Threshold: 0.2) Nuclear Threshold Adj Stat 22 (Threshold: 0.4) Nuclear Threshold Adj Stat 23 (Threshold: 0.2) Nuclear Threshold Adj Stat 23 (Threshold: 0.4) Nuclear Threshold Adj Stat 24 (Threshold: 0.2) Nuclear Threshold Adj Stat 24 (Threshold: 0.4) Nuclear Threshold Adj Stat 25 (Threshold: 0.2) Nuclear Threshold Adj Stat 25 (Threshold: 0.4) Nuclear Threshold Adj Stat 26 (Threshold: 0.2) Nuclear Threshold Adj Stat 26 (Threshold: 0.4) Nuclear Threshold Adj Stat 27 (Threshold: 0.2) Nuclear Threshold Adj Stat 27 (Threshold: 0.4) Nuclear Threshold Adj Stat 28 Nuclear Threshold Adj Stat 29 Nuclear Threshold Adj Stat 30 Nuclear Threshold Adj Stat 31 Nuclear Threshold Adj Stat 32 Nuclear Threshold Adj Stat 33 Nuclear Threshold Adj Stat 34 Nuclear Threshold Adj Stat 35 Nuclear Threshold Adj Stat 36 10% quantile of cytoplasm intensity (AU) 20% quantile of cytoplasm intensity (AU) 30% quantile of cytoplasm intensity (AU) 40% quantile of cytoplasm intensity (AU) 50% quantile of cytoplasm intensity (AU) 60% quantile of cytoplasm intensity (AU) 70% quantile of cytoplasm intensity (AU) 80% quantile of cytoplasm intensity (AU) 90% quantile of cytoplasm intensity (AU) Cytoplasmic Haralick ASM Cytoplasmic Haralick contrast Cytoplasmic Haralick entropy Cytoplasmic Haralick IDM Cytoplasmic Haralick moment 2 Cytoplasmic Haralick moment 3 Cytoplasmic Haralick moment 4 Cytoplasmic Haralick moment 5 Cytoplasmic radial moment (border) Cytoplasmic radial moment (center) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 28 Cytoplasmic Threshold Adj Stat 29 Cytoplasmic Threshold Adj Stat 30 Cytoplasmic Threshold Adj Stat 31 Cytoplasmic Threshold Adj Stat 32 Cytoplasmic Threshold Adj Stat 33 Cytoplasmic Threshold Adj Stat 34 Cytoplasmic Threshold Adj Stat 35 Cytoplasmic Threshold Adj Stat 36
MCF7 A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 619 317 image if available 7410 29983 364.7 86.29 152.06 265.97 260 289 313 336 358 380 405 434 477 0.0351 1051 1.206 108.37 43.84 1 0.0379 281 0.0006 87.06 7.645 0.1436 140416.0
57000000
24300000000
10900000000000
0.4464 0.2073 0.0005 0.0000 0.0018 0.0001 0.0086 0.0001 0.0271 0.0018 0.0873 0.0187 0.1534 0.0482 0.1532 0.0439 0.1846 0.0654 0.3836 0.8218 0.0000 0.0000 0.0003 0.0000 0.0009 0.0001 0.0081 0.0003 0.0365 0.0110 0.0711 0.0286 0.0684 0.0204 0.0949 0.0311 0.7198 0.9085 0.0050 0.0092 0.0093 0.0297 0.0328 0.0343 0.0734 0.0847 0.1290 0.1533 0.1917 0.2197 0.1226 0.1327 0.1347 0.1373 0.3015 0.1991 0.0006 0.0026 0.0110 0.0266 0.0747 0.1389 0.1155 0.1259 0.5043 7 9 11 13 20 43 110 258 517 0.1512 39.36 4.482 0.5817 93855.6
84800000
94200000000
120000000000000
0.4152 0.1980 0.0734 0.0021 0.2052 0.0259 0.2539 0.1687 0.1640 0.1542 0.1373 0.1932 0.0879 0.1763 0.0480 0.1107 0.0165 0.0824 0.0137 0.0866 0.0000 0.0002 0.0007 0.0005 0.0021 0.0003 0.0100 0.0059 0.0491 0.0469 0.0856 0.0756 0.0537 0.0477 0.0753 0.0702 0.7236 0.7526 0.0003 0.0001 0.0018 0.0006 0.0017 0.0025 0.0090 0.0096 0.0589 0.0634 0.0991 0.1035 0.0632 0.0706 0.0877 0.0978 0.6783 0.6519 0.0001 0.0011 0.0020 0.0119 0.0542 0.0904 0.0605 0.0819 0.6977
MCF7 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 162 234 image if available 7241 33553 311.8 96.47 118.63 162.69 187 201 237 287 318 345 372 400 436 0.0350 1175 0.651 97.19 15.30 2 0.0305 221 0.0011 37.81 7.274 0.2128 106500.0
39100000
15200000000
6200000000000
0.4774 0.1776 0.0004 0.0012 0.0025 0.0024 0.0078 0.0057 0.0252 0.0134 0.0900 0.0431 0.1460 0.0745 0.1488 0.0709 0.1729 0.1150 0.4064 0.6737 0.0000 0.0011 0.0000 0.0020 0.0012 0.0045 0.0020 0.0085 0.0163 0.0263 0.0285 0.0387 0.0281 0.0343 0.0386 0.0461 0.8853 0.8385 0.0024 0.0155 0.0043 0.0127 0.0119 0.0325 0.0396 0.0876 0.0835 0.1441 0.1098 0.1935 0.1150 0.1483 0.1394 0.1384 0.4940 0.2274 0.0000 0.0011 0.0029 0.0135 0.0296 0.0630 0.0643 0.0849 0.7407 9 11 14 19 34 73 138 222 342 0.1019 11.63 4.467 0.5909 40541.7
20200000
12600000000
9300000000000
0.3536 0.3217 0.0195 0.0035 0.1006 0.0081 0.1840 0.0477 0.1733 0.1043 0.1800 0.1722 0.1418 0.1779 0.1082 0.1344 0.0594 0.1368 0.0332 0.2151 0.0001 0.0006 0.0006 0.0005 0.0020 0.0011 0.0085 0.0076 0.0341 0.0295 0.0563 0.0485 0.0428 0.0362 0.0619 0.0541 0.7937 0.8219 0.0001 0.0002 0.0013 0.0015 0.0028 0.0035 0.0110 0.0135 0.0448 0.0478 0.0745 0.0869 0.0567 0.0645 0.0842 0.0980 0.7246 0.6843 0.0002 0.0009 0.0028 0.0099 0.0385 0.0629 0.0519 0.0705 0.7623
MCF7 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 503 432 image if available 11808 33332 318.9 77.36 142.89 210.03 224 252 274 294 313 332 354 382 421 0.0347 1158 1.075 96.88 32.00 1 0.0204 241 0.0011 35.28 7.136 0.2018 107664.0
38400000
14400000000
5670000000000
0.4385 0.2096 0.0001 0.0000 0.0004 0.0000 0.0068 0.0004 0.0240 0.0021 0.0823 0.0190 0.1435 0.0483 0.1432 0.0507 0.1608 0.0696 0.4388 0.8100 0.0000 0.0000 0.0000 0.0000 0.0015 0.0002 0.0071 0.0012 0.0317 0.0115 0.0656 0.0250 0.0600 0.0226 0.0788 0.0331 0.7553 0.9064 0.0047 0.0040 0.0064 0.0162 0.0180 0.0324 0.0588 0.1309 0.1171 0.1646 0.1656 0.2146 0.1257 0.1242 0.1416 0.1026 0.3621 0.2105 0.0020 0.0023 0.0069 0.0236 0.0705 0.1235 0.0941 0.1163 0.5608 6 7 9 11 20 67 166 292 458 0.1413 28.98 4.701 0.5652 64528.1
40100000
31100000000
29500000000000
0.4198 0.2297 0.0409 0.0008 0.1490 0.0130 0.2877 0.0770 0.1876 0.1317 0.1496 0.1991 0.0863 0.2098 0.0489 0.1278 0.0334 0.1018 0.0167 0.1390 0.0000 0.0000 0.0003 0.0003 0.0009 0.0007 0.0046 0.0041 0.0332 0.0264 0.0586 0.0502 0.0443 0.0368 0.0677 0.0562 0.7904 0.8252 0.0000 0.0002 0.0003 0.0008 0.0015 0.0014 0.0069 0.0086 0.0446 0.0485 0.0792 0.0935 0.0610 0.0660 0.0897 0.0966 0.7168 0.6842 0.0000 0.0006 0.0008 0.0069 0.0372 0.0677 0.0539 0.0771 0.7557
Hs 578T A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 224 664 image if available 23929 53243 235.7 71.53 198.53 308.24 140 172 197 217 235 254 274 298 328 0.0344 1829 0.641 165.59 39.45 7 0.0212 508 0.0005 51.67 7.813 0.1685 60653.4
16700000
4890000000
1500000000000
0.4168 0.2169 0.0013 0.0002 0.0025 0.0005 0.0085 0.0016 0.0313 0.0057 0.0797 0.0252 0.1433 0.0530 0.1429 0.0600 0.1764 0.0821 0.4142 0.7718 0.0006 0.0002 0.0010 0.0003 0.0020 0.0007 0.0074 0.0028 0.0227 0.0123 0.0429 0.0258 0.0415 0.0237 0.0600 0.0321 0.8218 0.9020 0.0018 0.0071 0.0045 0.0102 0.0154 0.0252 0.0432 0.0885 0.0873 0.1322 0.1280 0.1588 0.1107 0.1225 0.1340 0.1433 0.4752 0.3123 0.0008 0.0021 0.0061 0.0159 0.0445 0.0832 0.0794 0.1112 0.6569 15 19 23 31 50 98 191 331 581 0.0417 56.38 5.497 0.4839 134424.0
143000000
193000000000
306000000000000
0.3773 0.2809 0.0950 0.0031 0.2742 0.0340 0.2930 0.1903 0.1326 0.1923 0.0925 0.1954 0.0613 0.1542 0.0320 0.0969 0.0146 0.0718 0.0047 0.0620 0.0002 0.0002 0.0007 0.0005 0.0028 0.0019 0.0151 0.0118 0.0675 0.0598 0.1124 0.0965 0.0779 0.0655 0.1108 0.0997 0.6126 0.6642 0.0005 0.0011 0.0017 0.0024 0.0055 0.0069 0.0244 0.0283 0.0804 0.0894 0.1332 0.1361 0.0938 0.0992 0.1210 0.1267 0.5395 0.5097 0.0004 0.0016 0.0031 0.0214 0.0760 0.1177 0.0887 0.1187 0.5725
MCF 10A A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 593 809 image if available 9054 36760 386.6 78.38 181.80 168.48 283 319 345 368 389 408 428 453 485 0.0343 1261 1.172 117.32 46.07 2 0.0357 323 0.0013 28.99 6.930 0.2068 155613.0
64900000
28000000000
12400000000000
0.4514 0.1993 0.0003 0.0000 0.0003 0.0000 0.0031 0.0000 0.0122 0.0006 0.0609 0.0126 0.1366 0.0323 0.1416 0.0335 0.1674 0.0533 0.4776 0.8677 0.0001 0.0000 0.0000 0.0000 0.0009 0.0000 0.0025 0.0000 0.0256 0.0110 0.0577 0.0252 0.0556 0.0184 0.0717 0.0277 0.7858 0.9178 0.0076 0.0205 0.0124 0.1231 0.0275 0.0923 0.0927 0.1282 0.1683 0.1692 0.1999 0.1538 0.1484 0.0974 0.1374 0.1077 0.2060 0.1077 0.0006 0.0009 0.0039 0.0214 0.0744 0.1309 0.1084 0.1493 0.5102 20 40 70 101 134 175 226 293 410 0.0090 24.30 6.122 0.3733 61436.3
29700000
18600000000
14600000000000
0.4309 0.1918 0.0224 0.0007 0.1034 0.0058 0.2259 0.0487 0.1796 0.0900 0.1556 0.1611 0.1385 0.1955 0.0838 0.1496 0.0540 0.1427 0.0368 0.2058 0.0002 0.0003 0.0014 0.0006 0.0040 0.0027 0.0165 0.0104 0.0562 0.0443 0.1108 0.0905 0.0855 0.0719 0.1171 0.1021 0.6083 0.6773 0.0012 0.0016 0.0027 0.0043 0.0087 0.0124 0.0274 0.0393 0.0838 0.0961 0.1402 0.1499 0.1102 0.1133 0.1381 0.1378 0.4877 0.4453 0.0006 0.0015 0.0052 0.0174 0.0731 0.1259 0.1003 0.1286 0.5475
MCF7
0
DRAQ5 1 TMRE 2 2 2 1 241 848 image if available 10173 33400 558.7 106.36 141.20 210.07 440 469 494 517 539 564 595 638 721 0.0340 1136 1.181 125.88 48.08 1 0.0321 327 0.0010 33.71 7.169 0.1994 323447.0
194000000
121000000000
78500000000000
0.3999 0.2475 0.0004 0.0002 0.0009 0.0001 0.0027 0.0002 0.0123 0.0021 0.0344 0.0148 0.0701 0.0282 0.0822 0.0219 0.1201 0.0283 0.6769 0.9042 0.0002 0.0000 0.0004 0.0000 0.0012 0.0000 0.0077 0.0002 0.0193 0.0092 0.0401 0.0151 0.0464 0.0088 0.0651 0.0146 0.8195 0.9521 0.0060 0.0020 0.0079 0.0101 0.0113 0.0061 0.0344 0.0869 0.0656 0.1212 0.0947 0.2222 0.0742 0.1253 0.0947 0.1616 0.6113 0.2646 0.0019 0.0063 0.0137 0.0288 0.0574 0.1020 0.0876 0.1004 0.6019 7 9 12 16 31 71 144 264 446 0.0759 52.63 5.308 0.4892 64064.9
41000000
31800000000
28400000000000
0.3985 0.2299 0.1332 0.0028 0.3108 0.0481 0.2982 0.2452 0.1039 0.2139 0.0716 0.1845 0.0484 0.1328 0.0222 0.0737 0.0081 0.0576 0.0035 0.0413 0.0002 0.0002 0.0008 0.0002 0.0013 0.0007 0.0107 0.0085 0.0677 0.0583 0.1067 0.0940 0.0684 0.0620 0.1038 0.0989 0.6404 0.6771 0.0001 0.0001 0.0004 0.0005 0.0018 0.0038 0.0161 0.0195 0.0838 0.0907 0.1222 0.1354 0.0813 0.0869 0.1259 0.1305 0.5681 0.5326 0.0003 0.0006 0.0013 0.0134 0.0759 0.1150 0.0717 0.1123 0.6096
Hs 578T
0
DRAQ5 1 TMRE 2 2 2 1 334 363 image if available 15302 41714 244.9 60.87 131.95 179.42 171 196 213 227 242 257 273 292 320 0.0338 1411 0.710 67.01 10.63 1 0.0092 141 0.0009 32.33 7.369 0.2155 63663.8
17500000
5040000000
1520000000000
0.3811 0.2520 0.0003 0.0001 0.0018 0.0001 0.0054 0.0012 0.0129 0.0025 0.0443 0.0131 0.0775 0.0277 0.0883 0.0259 0.1303 0.0318 0.6391 0.8975 0.0001 0.0000 0.0009 0.0000 0.0019 0.0005 0.0043 0.0006 0.0157 0.0082 0.0271 0.0149 0.0311 0.0107 0.0502 0.0147 0.8688 0.9504 0.0040 0.0021 0.0074 0.0094 0.0148 0.0178 0.0415 0.0545 0.0820 0.1027 0.1180 0.1394 0.0981 0.1038 0.1164 0.1153 0.5177 0.4549 0.0010 0.0043 0.0084 0.0193 0.0357 0.0673 0.0704 0.0887 0.7048 13 17 21 29 47 80 136 229 381 0.0427 30.07 5.192 0.5095 49598.6
28100000
20000000000
16800000000000
0.3211 0.3337 0.0612 0.0021 0.1948 0.0183 0.2759 0.1123 0.1692 0.1501 0.1266 0.2025 0.0897 0.1912 0.0381 0.1170 0.0295 0.0975 0.0151 0.1089 0.0001 0.0001 0.0003 0.0005 0.0017 0.0013 0.0140 0.0104 0.0568 0.0497 0.0959 0.0827 0.0647 0.0548 0.0965 0.0855 0.6699 0.7149 0.0002 0.0004 0.0005 0.0012 0.0029 0.0045 0.0170 0.0211 0.0778 0.0843 0.1185 0.1332 0.0800 0.0874 0.1208 0.1226 0.5822 0.5453 0.0002 0.0013 0.0024 0.0139 0.0650 0.1091 0.0726 0.1074 0.6281
Hs 578T A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 1199 269 image if available 6858 34380 182.5 52.85 124.86 199.10 122 141 154 165 177 190 204 222 256 0.0332 1142 0.787 31.00 8.06 3 0.0117 80 0.0011 37.84 7.176 0.1947 36107.4
7670000
1740000000
418000000000
0.4164 0.2188 0.0008 0.0000 0.0016 0.0003 0.0074 0.0003 0.0251 0.0031 0.0740 0.0238 0.1294 0.0417 0.1524 0.0466 0.1762 0.0732 0.4332 0.8108 0.0004 0.0000 0.0004 0.0000 0.0034 0.0000 0.0103 0.0012 0.0321 0.0128 0.0530 0.0208 0.0614 0.0187 0.0821 0.0317 0.7569 0.9147 0.0035 0.0089 0.0090 0.0089 0.0097 0.0222 0.0520 0.0532 0.0929 0.1064 0.1283 0.1241 0.0999 0.1004 0.1200 0.1241 0.4847 0.4520 0.0016 0.0038 0.0074 0.0272 0.0579 0.0886 0.0908 0.1164 0.6063 17 21 25 29 35 48 91 194 364 0.0577 29.38 4.737 0.5383 55230.0
41200000
40500000000
47700000000000
0.3925 0.2378 0.1380 0.0050 0.3601 0.0465 0.2981 0.2724 0.1080 0.2297 0.0587 0.1914 0.0244 0.1219 0.0089 0.0649 0.0028 0.0419 0.0011 0.0263 0.0001 0.0001 0.0004 0.0005 0.0019 0.0020 0.0186 0.0147 0.0758 0.0670 0.1162 0.0990 0.0798 0.0694 0.1195 0.1071 0.5878 0.6402 0.0002 0.0003 0.0007 0.0022 0.0033 0.0056 0.0256 0.0302 0.0905 0.0964 0.1439 0.1483 0.0934 0.1014 0.1314 0.1378 0.5108 0.4778 0.0002 0.0007 0.0022 0.0238 0.0786 0.1331 0.0854 0.1281 0.5480
SK-BR-3 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 842 577 image if available 8312 37624 297.8 91.57 178.27 259.96 160 206 245 278 307 333 362 387 411 0.0319 1200 0.839 102.04 23.02 1 0.0298 248 0.0012 10.68 6.901 0.3043 97039.9
33700000
12200000000
4600000000000
0.3862 0.2351 0.0012 0.0000 0.0021 0.0005 0.0039 0.0017 0.0170 0.0054 0.0499 0.0240 0.0762 0.0398 0.0810 0.0408 0.1043 0.0580 0.6643 0.8299 0.0000 0.0000 0.0003 0.0001 0.0003 0.0001 0.0033 0.0020 0.0152 0.0128 0.0244 0.0202 0.0207 0.0155 0.0268 0.0229 0.9088 0.9263 0.0015 0.0106 0.0030 0.0151 0.0049 0.0408 0.0118 0.0711 0.0323 0.0968 0.0433 0.1452 0.0429 0.0953 0.0771 0.1589 0.7831 0.3661 0.0009 0.0016 0.0029 0.0068 0.0201 0.0316 0.0289 0.0382 0.8689 8 10 12 16 37 86 182 353 594 0.1248 17.36 4.816 0.6022 99357.5
73300000
62400000000
58600000000000
0.4227 0.2238 0.0264 0.0016 0.1059 0.0050 0.1959 0.0402 0.1696 0.0969 0.1979 0.1765 0.1462 0.2004 0.0726 0.1356 0.0497 0.1265 0.0358 0.2174 0.0000 0.0002 0.0005 0.0004 0.0018 0.0011 0.0067 0.0062 0.0389 0.0323 0.0555 0.0517 0.0427 0.0407 0.0604 0.0544 0.7937 0.8129 0.0002 0.0007 0.0011 0.0010 0.0034 0.0033 0.0119 0.0117 0.0387 0.0431 0.0656 0.0654 0.0477 0.0528 0.0658 0.0696 0.7657 0.7523 0.0000 0.0006 0.0016 0.0095 0.0399 0.0611 0.0434 0.0640 0.7799
MCF7 A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 803 843 image if available 8078 37469 422.2 79.09 159.69 223.20 327 354 375 397 417 437 459 489 531 0.0317 1189 1.189 110.68 36.67 1 0.0326 263 0.0007 56.32 7.529 0.1530 184520.0
83400000
38900000000
18700000000000
0.4100 0.2411 0.0003 0.0000 0.0005 0.0000 0.0026 0.0001 0.0130 0.0004 0.0471 0.0139 0.1043 0.0293 0.1147 0.0226 0.1480 0.0455 0.5695 0.8882 0.0000 0.0000 0.0003 0.0000 0.0013 0.0000 0.0050 0.0000 0.0239 0.0107 0.0515 0.0209 0.0493 0.0112 0.0688 0.0227 0.8000 0.9344 0.0074 0.0206 0.0033 0.0155 0.0294 0.0722 0.0711 0.1598 0.1266 0.2268 0.1585 0.1701 0.1152 0.1495 0.1479 0.0979 0.3407 0.0876 0.0005 0.0054 0.0099 0.0311 0.0677 0.1022 0.1066 0.1196 0.5569 8 12 18 34 59 102 172 277 460 0.0551 26.43 5.339 0.4890 75319.8
53300000
47300000000
49000000000000
0.3610 0.2741 0.0647 0.0026 0.2087 0.0190 0.2734 0.1221 0.1568 0.1521 0.1237 0.2054 0.0877 0.1850 0.0465 0.1224 0.0270 0.0989 0.0115 0.0926 0.0006 0.0004 0.0007 0.0010 0.0031 0.0025 0.0146 0.0116 0.0594 0.0555 0.0986 0.0841 0.0693 0.0619 0.0969 0.0912 0.6568 0.6917 0.0009 0.0003 0.0015 0.0012 0.0039 0.0068 0.0169 0.0173 0.0767 0.0907 0.1116 0.1149 0.0824 0.0817 0.1129 0.1235 0.5932 0.5636 0.0006 0.0018 0.0039 0.0139 0.0709 0.1068 0.0718 0.1079 0.6224
Hs 578T Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 903 431 image if available 54613 82874 84.8 46.65 114.00 205.41 23 28 54 73 87 99 112 126 146 0.0303 2514 0.607 231.82 52.47 24 0.0118 645 0.0046 13.65 6.351 0.3627 9367.0
1190000
165000000
24700000000
0.5125 0.1476 0.0017 0.0007 0.0076 0.0010 0.0380 0.0040 0.0801 0.0150 0.1435 0.0575 0.1828 0.1084 0.1675 0.1062 0.1626 0.1362 0.2163 0.5709 0.0002 0.0000 0.0004 0.0000 0.0014 0.0002 0.0055 0.0015 0.0213 0.0119 0.0388 0.0234 0.0374 0.0198 0.0551 0.0316 0.8399 0.9117 0.0006 0.0018 0.0028 0.0048 0.0065 0.0130 0.0229 0.0391 0.0576 0.0808 0.0882 0.1189 0.0857 0.0985 0.1117 0.1228 0.6241 0.5203 0.0004 0.0014 0.0040 0.0124 0.0339 0.0605 0.0589 0.0824 0.7461 10 12 13 15 18 26 61 174 383 0.2390 19.16 3.787 0.6638 55186.4
40400000
36400000000
37700000000000
0.4605 0.1949 0.1576 0.0035 0.3814 0.0611 0.3071 0.3277 0.0839 0.2234 0.0408 0.1726 0.0158 0.1086 0.0071 0.0487 0.0039 0.0298 0.0026 0.0245 0.0001 0.0001 0.0006 0.0003 0.0013 0.0008 0.0117 0.0106 0.0652 0.0602 0.1027 0.0939 0.0640 0.0575 0.0983 0.0881 0.6561 0.6885 0.0000 0.0004 0.0009 0.0009 0.0020 0.0025 0.0164 0.0184 0.0742 0.0778 0.1173 0.1225 0.0764 0.0817 0.1085 0.1098 0.6044 0.5860 0.0001 0.0002 0.0017 0.0132 0.0722 0.1105 0.0693 0.1056 0.6272
MCF7 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 234 799 image if available 13982 47347 267.6 72.72 111.48 151.15 180 206 227 244 261 277 298 324 366 0.0290 1375 0.637 134.38 29.41 4 0.0255 356 0.0013 25.91 6.963 0.2170 76872.3
23600000
7750000000
2700000000000
0.4326 0.2214 0.0001 0.0000 0.0013 0.0001 0.0055 0.0004 0.0221 0.0029 0.0806 0.0231 0.1501 0.0550 0.1533 0.0526 0.1827 0.0775 0.4043 0.7885 0.0000 0.0000 0.0003 0.0000 0.0018 0.0002 0.0076 0.0010 0.0363 0.0137 0.0660 0.0277 0.0623 0.0230 0.0865 0.0394 0.7392 0.8952 0.0052 0.0034 0.0097 0.0101 0.0207 0.0151 0.0446 0.0772 0.1034 0.1394 0.1383 0.2065 0.0906 0.0999 0.1317 0.1360 0.4557 0.3123 0.0005 0.0028 0.0097 0.0328 0.0738 0.1215 0.0977 0.1158 0.5454 7 9 11 16 39 79 133 204 314 0.0819 10.81 4.504 0.5328 35272.3
16700000
10300000000
7940000000000
0.3283 0.3071 0.0637 0.0018 0.1924 0.0219 0.2593 0.1299 0.1590 0.1336 0.1409 0.1843 0.0919 0.1786 0.0492 0.1220 0.0306 0.1122 0.0130 0.1156 0.0001 0.0000 0.0004 0.0004 0.0007 0.0005 0.0071 0.0063 0.0513 0.0394 0.0875 0.0698 0.0707 0.0553 0.1096 0.0865 0.6726 0.7417 0.0003 0.0002 0.0010 0.0011 0.0030 0.0057 0.0155 0.0207 0.0717 0.0816 0.1258 0.1367 0.0873 0.0954 0.1313 0.1337 0.5642 0.5249 0.0001 0.0005 0.0021 0.0105 0.0627 0.1064 0.0809 0.1220 0.6149
SK-BR-3 A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 969 728 image if available 16378 49009 195.5 37.68 203.96 331.62 151 169 180 189 198 206 215 226 241 0.0278 1362 1.188 93.09 34.48 1 0.0143 235 0.0032 12.80 6.161 0.3225 39638.5
8270000
1770000000
387000000000
0.4222 0.2262 0.0002 0.0000 0.0012 0.0000 0.0037 0.0000 0.0129 0.0003 0.0346 0.0080 0.0661 0.0181 0.0824 0.0160 0.1152 0.0268 0.6836 0.9309 0.0001 0.0000 0.0003 0.0000 0.0008 0.0000 0.0036 0.0001 0.0120 0.0068 0.0260 0.0139 0.0283 0.0069 0.0418 0.0107 0.8870 0.9616 0.0089 0.0576 0.0166 0.0995 0.0426 0.1047 0.0736 0.1780 0.1192 0.1937 0.1473 0.1675 0.1256 0.0733 0.1456 0.0890 0.3206 0.0366 0.0012 0.0027 0.0072 0.0202 0.0501 0.0834 0.0821 0.1197 0.6333 7 8 10 12 17 54 192 390 701 0.1432 35.53 4.788 0.5519 151568.0
149000000
169000000000
211000000000000
0.4292 0.2197 0.0529 0.0035 0.2034 0.0131 0.2775 0.1127 0.1544 0.1604 0.1262 0.2014 0.0909 0.1979 0.0516 0.1081 0.0322 0.1003 0.0110 0.1027 0.0001 0.0001 0.0003 0.0001 0.0010 0.0003 0.0081 0.0057 0.0395 0.0371 0.0691 0.0641 0.0487 0.0414 0.0700 0.0648 0.7633 0.7864 0.0004 0.0003 0.0011 0.0011 0.0028 0.0036 0.0129 0.0138 0.0452 0.0466 0.0753 0.0825 0.0565 0.0561 0.0729 0.0789 0.7329 0.7170 0.0001 0.0013 0.0022 0.0102 0.0423 0.0730 0.0512 0.0723 0.7473
SK-BR-3 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 518 503 image if available 15648 56021 320.9 59.50 142.33 181.99 244 279 299 315 329 341 354 368 389 0.0239 1341 0.987 126.85 36.01 1 0.0202 316 0.0015 21.65 6.855 0.2488 106538.0
36300000
12600000000
4480000000000
0.4413 0.2040 0.0005 0.0000 0.0005 0.0000 0.0020 0.0000 0.0079 0.0003 0.0295 0.0078 0.0562 0.0157 0.0615 0.0104 0.0915 0.0162 0.7503 0.9496 0.0000 0.0000 0.0000 0.0000 0.0002 0.0000 0.0023 0.0003 0.0109 0.0075 0.0242 0.0143 0.0210 0.0081 0.0316 0.0119 0.9098 0.9580 0.0090 0.0536 0.0157 0.0179 0.0336 0.1429 0.0745 0.2143 0.1272 0.1429 0.1557 0.1607 0.1429 0.1071 0.1597 0.0357 0.2818 0.1250 0.0008 0.0025 0.0050 0.0158 0.0410 0.0684 0.0815 0.0977 0.6873 8 10 12 18 51 108 178 269 424 0.1076 16.66 4.969 0.5393 53375.8
26600000
15300000000
9680000000000
0.3694 0.2725 0.0166 0.0013 0.1012 0.0060 0.2168 0.0361 0.1910 0.0912 0.1770 0.1724 0.1403 0.2115 0.0824 0.1547 0.0457 0.1475 0.0291 0.1792 0.0006 0.0002 0.0006 0.0006 0.0027 0.0015 0.0085 0.0065 0.0354 0.0299 0.0682 0.0565 0.0555 0.0459 0.0719 0.0641 0.7567 0.7947 0.0005 0.0005 0.0022 0.0022 0.0040 0.0048 0.0126 0.0154 0.0463 0.0551 0.0837 0.0934 0.0695 0.0743 0.0862 0.0911 0.6950 0.6633 0.0005 0.0017 0.0041 0.0114 0.0416 0.0737 0.0613 0.0797 0.7260