High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
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| Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
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| SK-BR-3 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1220 | 451 | | 11232 | 18145 | 198.9 | 80.62 | 6.13 | 2.92 | 96 | 118 | 138 | 163 | 190 | 224 | 254 | 281 | 308 | 0.0881 | 1598 | 0.402 | 135.09 | 20.03 | 6 | 0.0363 | 408 | 0.0017 | 7.54 | 6.630 | 0.3605 | 46068.3 | 11900000 | 3280000000 | 953000000000 | 0.4257 | 0.1921 | 0.0034 | 0.0015 | 0.0058 | 0.0030 | 0.0089 | 0.0074 | 0.0294 | 0.0164 | 0.0684 | 0.0406 | 0.1042 | 0.0619 | 0.1097 | 0.0584 | 0.1415 | 0.0780 | 0.5287 | 0.7328 | 0.0006 | 0.0003 | 0.0010 | 0.0001 | 0.0022 | 0.0029 | 0.0064 | 0.0067 | 0.0146 | 0.0168 | 0.0254 | 0.0283 | 0.0235 | 0.0230 | 0.0296 | 0.0320 | 0.8967 | 0.8898 | 0.0005 | 0.0025 | 0.0033 | 0.0051 | 0.0060 | 0.0132 | 0.0098 | 0.0229 | 0.0280 | 0.0467 | 0.0282 | 0.0642 | 0.0358 | 0.0778 | 0.0499 | 0.0999 | 0.8385 | 0.6677 | 0.0009 | 0.0007 | 0.0024 | 0.0073 | 0.0189 | 0.0239 | 0.0284 | 0.0375 | 0.8799 | 3 | 4 | 5 | 5 | 6 | 7 | 7 | 8 | 9 | 0.1305 | 0.44 | 1.002 | 0.4054 | 46.1 | 458.785 | 7687.85 | 234458 | 0.5483 | 0.1268 | 0.0123 | 0.0015 | 0.0555 | 0.0107 | 0.1399 | 0.0297 | 0.2151 | 0.0734 | 0.2476 | 0.1533 | 0.1919 | 0.2308 | 0.1031 | 0.2579 | 0.0306 | 0.1797 | 0.0042 | 0.0631 | 0.0008 | 0.0001 | 0.0083 | 0.0014 | 0.0270 | 0.0074 | 0.0633 | 0.0263 | 0.1189 | 0.0658 | 0.1643 | 0.1156 | 0.2017 | 0.2003 | 0.2201 | 0.2840 | 0.1956 | 0.2992 | 0.1197 | 0.2233 | 0.1816 | 0.2100 | 0.1733 | 0.1903 | 0.1579 | 0.1256 | 0.1231 | 0.0803 | 0.0916 | 0.0538 | 0.0625 | 0.0439 | 0.0525 | 0.0381 | 0.0379 | 0.0347 | 0.0066 | 0.0454 | 0.0962 | 0.1383 | 0.1787 | 0.1873 | 0.1512 | 0.1164 | 0.0797 |
| Hs 578T | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 800 | 501 | | 13792 | 38751 | 266.6 | 61.19 | 169.99 | 277.73 | 192 | 219 | 237 | 253 | 267 | 281 | 297 | 317 | 345 | 0.0391 | 1515 | 0.913 | 98.60 | 27.17 | 6 | 0.0188 | 259 | 0.0012 | 28.43 | 7.043 | 0.2221 | 74836.6 | 21900000 | 6660000000 | 2090000000000 | 0.4163 | 0.2227 | 0.0000 | 0.0000 | 0.0013 | 0.0000 | 0.0034 | 0.0004 | 0.0145 | 0.0030 | 0.0508 | 0.0123 | 0.1000 | 0.0294 | 0.1083 | 0.0291 | 0.1428 | 0.0414 | 0.5789 | 0.8845 | 0.0000 | 0.0000 | 0.0006 | 0.0000 | 0.0009 | 0.0002 | 0.0051 | 0.0012 | 0.0181 | 0.0073 | 0.0381 | 0.0171 | 0.0415 | 0.0105 | 0.0570 | 0.0160 | 0.8387 | 0.9478 | 0.0032 | 0.0074 | 0.0083 | 0.0315 | 0.0221 | 0.0612 | 0.0437 | 0.1169 | 0.1095 | 0.1818 | 0.1536 | 0.1892 | 0.1312 | 0.1373 | 0.1276 | 0.1150 | 0.4009 | 0.1596 | 0.0001 | 0.0023 | 0.0069 | 0.0225 | 0.0520 | 0.0995 | 0.0920 | 0.1141 | 0.6107 | 11 | 14 | 16 | 21 | 32 | 62 | 139 | 285 | 553 | 0.1524 | 25.56 | 4.437 | 0.6078 | 106029.0 | 97600000 | 110000000000 | 141000000000000 | 0.3354 | 0.3305 | 0.0662 | 0.0027 | 0.2254 | 0.0240 | 0.2667 | 0.1419 | 0.1607 | 0.1818 | 0.1295 | 0.1818 | 0.0830 | 0.1829 | 0.0379 | 0.1071 | 0.0230 | 0.0916 | 0.0077 | 0.0861 | 0.0003 | 0.0003 | 0.0010 | 0.0006 | 0.0035 | 0.0021 | 0.0193 | 0.0153 | 0.0582 | 0.0549 | 0.0728 | 0.0726 | 0.0478 | 0.0442 | 0.0766 | 0.0719 | 0.7205 | 0.7381 | 0.0006 | 0.0007 | 0.0019 | 0.0018 | 0.0059 | 0.0059 | 0.0221 | 0.0258 | 0.0548 | 0.0602 | 0.0841 | 0.0861 | 0.0579 | 0.0644 | 0.0867 | 0.0924 | 0.6859 | 0.6628 | 0.0003 | 0.0015 | 0.0047 | 0.0221 | 0.0559 | 0.0766 | 0.0542 | 0.0790 | 0.7058 |
| MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 923 | 876 | | 4650 | 27974 | 298.2 | 83.39 | 212.92 | 186.19 | 196 | 225 | 246 | 269 | 291 | 315 | 341 | 374 | 413 | 0.0507 | 1418 | 1.135 | 46.75 | 17.00 | 6 | 0.0265 | 123 | 0.0006 | 64.25 | 7.641 | 0.1408 | 95900.4 | 32900000 | 11900000000 | 4530000000000 | 0.4875 | 0.1659 | 0.0004 | 0.0000 | 0.0022 | 0.0008 | 0.0057 | 0.0008 | 0.0284 | 0.0091 | 0.1091 | 0.0467 | 0.1916 | 0.0965 | 0.1414 | 0.0657 | 0.1689 | 0.1033 | 0.3522 | 0.6771 | 0.0000 | 0.0000 | 0.0009 | 0.0007 | 0.0020 | 0.0000 | 0.0128 | 0.0059 | 0.0483 | 0.0320 | 0.0762 | 0.0692 | 0.0556 | 0.0391 | 0.0829 | 0.0608 | 0.7213 | 0.7923 | 0.0017 | 0.0048 | 0.0035 | 0.0095 | 0.0096 | 0.0263 | 0.0192 | 0.0668 | 0.0925 | 0.1265 | 0.1187 | 0.1384 | 0.0855 | 0.1289 | 0.1309 | 0.1480 | 0.5384 | 0.3508 | 0.0014 | 0.0009 | 0.0059 | 0.0237 | 0.0702 | 0.0916 | 0.0766 | 0.0861 | 0.6436 | 27 | 52 | 83 | 117 | 157 | 208 | 270 | 356 | 482 | 0.0050 | 46.50 | 6.695 | 0.3231 | 79998.9 | 40100000 | 24000000000 | 16200000000000 | 0.4940 | 0.1623 | 0.0270 | 0.0010 | 0.1183 | 0.0111 | 0.2093 | 0.0488 | 0.1802 | 0.0945 | 0.1620 | 0.1643 | 0.1329 | 0.2010 | 0.0821 | 0.1517 | 0.0530 | 0.1382 | 0.0352 | 0.1895 | 0.0007 | 0.0001 | 0.0014 | 0.0010 | 0.0042 | 0.0026 | 0.0218 | 0.0137 | 0.0642 | 0.0508 | 0.1052 | 0.0828 | 0.0816 | 0.0668 | 0.1081 | 0.0927 | 0.6129 | 0.6894 | 0.0013 | 0.0016 | 0.0028 | 0.0069 | 0.0105 | 0.0144 | 0.0378 | 0.0507 | 0.0975 | 0.1038 | 0.1384 | 0.1575 | 0.1063 | 0.1060 | 0.1287 | 0.1379 | 0.4767 | 0.4212 | 0.0009 | 0.0024 | 0.0075 | 0.0292 | 0.0795 | 0.1238 | 0.0924 | 0.1217 | 0.5426 |
| SK-BR-3 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 762 | 189 | | 1376 | 10419 | 35.3 | 9.21 | 10.27 | 5.63 | 22 | 26 | 29 | 33 | 36 | 39 | 42 | 44 | 47 | 0.0696 | 725 | 0.931 | 32.02 | 6.00 | 6 | 0.0509 | 70 | 0.0514 | 0.71 | 3.174 | 0.7185 | 1329.9 | 52792.9 | 2180000 | 92900000 | 0.3888 | 0.2401 | 0.0112 | 0.0000 | 0.0224 | 0.0000 | 0.0384 | 0.0041 | 0.0480 | 0.0132 | 0.0880 | 0.0438 | 0.1296 | 0.0661 | 0.1552 | 0.0867 | 0.2224 | 0.1189 | 0.2848 | 0.6672 | 0.0038 | 0.0000 | 0.0029 | 0.0000 | 0.0105 | 0.0023 | 0.0134 | 0.0077 | 0.0335 | 0.0302 | 0.0374 | 0.0294 | 0.0412 | 0.0394 | 0.0766 | 0.0510 | 0.7807 | 0.8399 | 0.0167 | 0.0854 | 0.0143 | 0.1707 | 0.0263 | 0.1341 | 0.0430 | 0.2073 | 0.0740 | 0.1463 | 0.0883 | 0.2073 | 0.0931 | 0.0244 | 0.1551 | 0.0244 | 0.4893 | 0.0000 | 0.0027 | 0.0040 | 0.0121 | 0.0214 | 0.0429 | 0.0402 | 0.0657 | 0.0979 | 0.7131 | 5 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 15 | 0.2596 | 0.30 | 0.975 | 0.6174 | 137.1 | 3359.17 | 189453 | 16100000 | 0.5305 | 0.1486 | 0.0352 | 0.0019 | 0.0945 | 0.0122 | 0.1668 | 0.0289 | 0.2222 | 0.0571 | 0.2112 | 0.0964 | 0.1536 | 0.1503 | 0.0877 | 0.2161 | 0.0244 | 0.2552 | 0.0044 | 0.1819 | 0.0068 | 0.0000 | 0.0230 | 0.0021 | 0.0437 | 0.0082 | 0.0549 | 0.0212 | 0.0735 | 0.0449 | 0.0787 | 0.0675 | 0.1107 | 0.0939 | 0.1744 | 0.1513 | 0.4343 | 0.6109 | 0.0472 | 0.0923 | 0.0513 | 0.1077 | 0.0808 | 0.1294 | 0.1073 | 0.1464 | 0.1292 | 0.1422 | 0.1429 | 0.1316 | 0.1703 | 0.1167 | 0.1551 | 0.0716 | 0.1158 | 0.0621 | 0.0303 | 0.0432 | 0.0455 | 0.0586 | 0.0760 | 0.1103 | 0.1403 | 0.2192 | 0.2767 |
| MDA-MB-231 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 945 | 791 | | 7136 | 8653 | 396.4 | 68.86 | 331.09 | 487.17 | 292 | 338 | 365 | 386 | 406 | 423 | 439 | 454 | 478 | 0.0953 | 825 | 1.046 | 109.66 | 38.48 | 6 | 0.0419 | 299 | 0.0024 | 9.08 | 6.362 | 0.3660 | 161888.0 | 67800000 | 29000000000 | 12700000000000 | 0.4181 | 0.2153 | 0.0006 | 0.0000 | 0.0015 | 0.0000 | 0.0038 | 0.0000 | 0.0079 | 0.0011 | 0.0218 | 0.0106 | 0.0533 | 0.0271 | 0.0385 | 0.0132 | 0.0585 | 0.0186 | 0.8142 | 0.9294 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0005 | 0.0000 | 0.0025 | 0.0011 | 0.0113 | 0.0105 | 0.0289 | 0.0260 | 0.0141 | 0.0119 | 0.0204 | 0.0173 | 0.9222 | 0.9333 | 0.0066 | 0.0000 | 0.0066 | 0.0000 | 0.0263 | 0.0000 | 0.0447 | 0.0000 | 0.1092 | 0.0000 | 0.1184 | 0.0000 | 0.1158 | 0.0000 | 0.1382 | 0.0000 | 0.4342 | 0.0000 | 0.0005 | 0.0015 | 0.0051 | 0.0101 | 0.0281 | 0.0398 | 0.0367 | 0.0529 | 0.8252 | 10 | 12 | 15 | 26 | 85 | 211 | 381 | 631 | 998 | 0.1055 | 26.80 | 5.014 | 0.5502 | 346927.0 | 541000000 | 1110000000000 | 2.77E+15 | 0.4761 | 0.1685 | 0.0161 | 0.0031 | 0.0966 | 0.0086 | 0.1804 | 0.0350 | 0.1739 | 0.0871 | 0.1643 | 0.1540 | 0.1433 | 0.1882 | 0.0934 | 0.1407 | 0.0805 | 0.1198 | 0.0515 | 0.2636 | 0.0003 | 0.0008 | 0.0006 | 0.0014 | 0.0025 | 0.0017 | 0.0063 | 0.0068 | 0.0348 | 0.0256 | 0.0659 | 0.0501 | 0.0446 | 0.0400 | 0.0681 | 0.0535 | 0.7768 | 0.8202 | 0.0000 | 0.0004 | 0.0004 | 0.0018 | 0.0039 | 0.0049 | 0.0102 | 0.0123 | 0.0481 | 0.0511 | 0.0777 | 0.0886 | 0.0560 | 0.0675 | 0.0765 | 0.0825 | 0.7272 | 0.6909 | 0.0000 | 0.0004 | 0.0036 | 0.0093 | 0.0411 | 0.0750 | 0.0496 | 0.0650 | 0.7562 |
| MDA-MB-231 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 481 | 100 | | 7950 | 9207 | 278.6 | 129.42 | 10.26 | 12.06 | 144 | 163 | 187 | 215 | 241 | 273 | 314 | 413 | 495 | 0.0924 | 851 | 0.695 | 94.53 | 15.03 | 6 | 0.0267 | 212 | 0.0018 | 9.35 | 6.724 | 0.3596 | 94338.5 | 37400000 | 16500000000 | 7810000000000 | 0.4212 | 0.2162 | 0.0009 | 0.0016 | 0.0013 | 0.0016 | 0.0068 | 0.0043 | 0.0175 | 0.0086 | 0.0554 | 0.0374 | 0.0967 | 0.0491 | 0.0797 | 0.0423 | 0.1121 | 0.0623 | 0.6297 | 0.7930 | 0.0004 | 0.0011 | 0.0007 | 0.0010 | 0.0027 | 0.0027 | 0.0064 | 0.0047 | 0.0202 | 0.0199 | 0.0282 | 0.0236 | 0.0285 | 0.0216 | 0.0407 | 0.0308 | 0.8721 | 0.8946 | 0.0009 | 0.0000 | 0.0009 | 0.0000 | 0.0028 | 0.0017 | 0.0070 | 0.0091 | 0.0167 | 0.0205 | 0.0423 | 0.0400 | 0.0265 | 0.0377 | 0.0307 | 0.0354 | 0.8721 | 0.8556 | 0.0010 | 0.0016 | 0.0049 | 0.0092 | 0.0191 | 0.0384 | 0.0309 | 0.0427 | 0.8521 | 3 | 5 | 5 | 6 | 7 | 8 | 9 | 11 | 19 | 0.1322 | 0.45 | 1.509 | 0.5124 | 250.6 | 12213 | 813301 | 62700000 | 0.5153 | 0.1526 | 0.0886 | 0.0079 | 0.2162 | 0.0407 | 0.2503 | 0.0797 | 0.2088 | 0.1421 | 0.1362 | 0.1824 | 0.0696 | 0.1959 | 0.0225 | 0.1743 | 0.0078 | 0.1275 | 0.0000 | 0.0493 | 0.0425 | 0.0045 | 0.1012 | 0.0274 | 0.1320 | 0.0540 | 0.1129 | 0.0995 | 0.0975 | 0.1431 | 0.0935 | 0.1554 | 0.0649 | 0.1304 | 0.0728 | 0.1196 | 0.2827 | 0.2662 | 0.0790 | 0.0376 | 0.0515 | 0.0295 | 0.0334 | 0.0302 | 0.0322 | 0.0376 | 0.0632 | 0.0604 | 0.0971 | 0.1150 | 0.0872 | 0.0825 | 0.0989 | 0.1098 | 0.4576 | 0.4974 | 0.1005 | 0.0895 | 0.0781 | 0.0561 | 0.0570 | 0.0875 | 0.0557 | 0.0858 | 0.3897 | ||
| SK-BR-3 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 1199 | 461 | | 4972 | 6147 | 193.3 | 101.39 | 92.03 | 198.27 | 86 | 103 | 120 | 137 | 155 | 189 | 252 | 298 | 348 | 0.1223 | 752 | 0.646 | 151.35 | 28.23 | 6 | 0.0686 | 341 | 0.0019 | 14.93 | 6.742 | 0.3352 | 47639.3 | 13900000 | 4520000000 | 1570000000000 | 0.3496 | 0.2649 | 0.0060 | 0.0004 | 0.0048 | 0.0035 | 0.0132 | 0.0052 | 0.0396 | 0.0148 | 0.1321 | 0.0461 | 0.2233 | 0.0804 | 0.1417 | 0.0722 | 0.1573 | 0.1039 | 0.2821 | 0.6735 | 0.0016 | 0.0003 | 0.0016 | 0.0017 | 0.0036 | 0.0011 | 0.0084 | 0.0058 | 0.0244 | 0.0172 | 0.0407 | 0.0302 | 0.0339 | 0.0266 | 0.0395 | 0.0388 | 0.8462 | 0.8784 | 0.0000 | 0.0008 | 0.0006 | 0.0015 | 0.0012 | 0.0061 | 0.0096 | 0.0107 | 0.0215 | 0.0313 | 0.0413 | 0.0595 | 0.0311 | 0.0489 | 0.0431 | 0.0794 | 0.8516 | 0.7618 | 0.0005 | 0.0000 | 0.0005 | 0.0046 | 0.0245 | 0.0408 | 0.0245 | 0.0362 | 0.8684 | 6 | 7 | 9 | 10 | 13 | 18 | 35 | 93 | 274 | 0.1539 | 10.11 | 3.626 | 0.6621 | 47772.6 | 36200000 | 31300000000 | 29200000000000 | 0.4667 | 0.1877 | 0.0120 | 0.0059 | 0.0518 | 0.0098 | 0.1076 | 0.0234 | 0.1992 | 0.0508 | 0.2231 | 0.1484 | 0.1673 | 0.2266 | 0.0916 | 0.1348 | 0.0598 | 0.1465 | 0.0876 | 0.2539 | 0.0007 | 0.0013 | 0.0036 | 0.0026 | 0.0051 | 0.0078 | 0.0182 | 0.0156 | 0.0547 | 0.0591 | 0.0591 | 0.0604 | 0.0562 | 0.0558 | 0.0795 | 0.0734 | 0.7228 | 0.7240 | 0.0000 | 0.0010 | 0.0063 | 0.0019 | 0.0063 | 0.0039 | 0.0116 | 0.0068 | 0.0634 | 0.0623 | 0.0598 | 0.0700 | 0.0625 | 0.0623 | 0.0938 | 0.0944 | 0.6964 | 0.6975 | 0.0008 | 0.0041 | 0.0081 | 0.0122 | 0.0575 | 0.0632 | 0.0624 | 0.0875 | 0.7042 |
| MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 968 | 293 | | 9056 | 13099 | 516.1 | 88.24 | 114.69 | 251.28 | 396 | 459 | 491 | 512 | 529 | 545 | 562 | 583 | 612 | 0.0837 | 1097 | 0.940 | 103.45 | 28.16 | 6 | 0.0282 | 255 | 0.0009 | 51.99 | 7.361 | 0.1986 | 274112.0 | 149000000 | 82200000000 | 46100000000000 | 0.4370 | 0.2059 | 0.0001 | 0.0000 | 0.0001 | 0.0000 | 0.0006 | 0.0000 | 0.0050 | 0.0007 | 0.0278 | 0.0152 | 0.0543 | 0.0277 | 0.0482 | 0.0150 | 0.0760 | 0.0288 | 0.7879 | 0.9127 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0019 | 0.0007 | 0.0168 | 0.0152 | 0.0317 | 0.0272 | 0.0203 | 0.0143 | 0.0351 | 0.0258 | 0.8942 | 0.9168 | 0.0106 | 0.0000 | 0.0080 | 0.0000 | 0.0359 | 0.0000 | 0.0638 | 0.0000 | 0.1237 | 0.0000 | 0.1463 | 0.0000 | 0.1077 | 0.0000 | 0.1303 | 0.0000 | 0.3737 | 0.0000 | 0.0015 | 0.0017 | 0.0063 | 0.0160 | 0.0428 | 0.0699 | 0.0713 | 0.1070 | 0.6836 | 8 | 10 | 12 | 14 | 20 | 34 | 63 | 120 | 305 | 0.0778 | 7.79 | 3.212 | 0.5546 | 76290.7 | 93700000 | 170000000000 | 429000000000000 | 0.7394 | 0.0357 | 0.0196 | 0.0006 | 0.0825 | 0.0106 | 0.1649 | 0.0417 | 0.1872 | 0.0636 | 0.1702 | 0.1514 | 0.1584 | 0.2125 | 0.1152 | 0.1383 | 0.0654 | 0.1383 | 0.0366 | 0.2430 | 0.0003 | 0.0000 | 0.0019 | 0.0013 | 0.0083 | 0.0037 | 0.0156 | 0.0088 | 0.0568 | 0.0470 | 0.0879 | 0.0948 | 0.0632 | 0.0564 | 0.0959 | 0.0866 | 0.6702 | 0.7013 | 0.0008 | 0.0005 | 0.0004 | 0.0014 | 0.0059 | 0.0028 | 0.0184 | 0.0229 | 0.0675 | 0.0744 | 0.1010 | 0.1155 | 0.0700 | 0.0734 | 0.1014 | 0.1001 | 0.6345 | 0.6090 | 0.0015 | 0.0018 | 0.0041 | 0.0170 | 0.0595 | 0.0983 | 0.0698 | 0.0953 | 0.6526 |
| MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 771 | 431 | | 4723 | 9875 | 420.9 | 161.67 | 55.15 | 99.89 | 200 | 251 | 303 | 365 | 431 | 482 | 522 | 568 | 629 | 0.0788 | 778 | 0.731 | 105.48 | 21.21 | 6 | 0.0565 | 267 | 0.0006 | 80.85 | 7.710 | 0.1749 | 203288.0 | 108000000 | 61500000000 | 36800000000000 | 0.4984 | 0.1471 | 0.0007 | 0.0003 | 0.0007 | 0.0010 | 0.0216 | 0.0033 | 0.0404 | 0.0080 | 0.1246 | 0.0501 | 0.1865 | 0.0951 | 0.1461 | 0.0607 | 0.1538 | 0.0921 | 0.3257 | 0.6894 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0046 | 0.0034 | 0.0355 | 0.0308 | 0.0624 | 0.0490 | 0.0309 | 0.0300 | 0.0558 | 0.0477 | 0.8106 | 0.8391 | 0.0012 | 0.0000 | 0.0025 | 0.0000 | 0.0037 | 0.0000 | 0.0211 | 0.0000 | 0.0460 | 0.0000 | 0.0814 | 0.0000 | 0.0534 | 0.0000 | 0.0764 | 0.0000 | 0.7141 | 1.0000 | 0.0000 | 0.0000 | 0.0004 | 0.0061 | 0.0442 | 0.0626 | 0.0421 | 0.0646 | 0.7799 | 10 | 11 | 12 | 13 | 15 | 20 | 30 | 66 | 151 | 0.2033 | 1.45 | 2.515 | 0.7047 | 13017.7 | 5530000 | 3000000000 | 1870000000000 | 0.6272 | 0.0766 | 0.0281 | 0.0028 | 0.0884 | 0.0139 | 0.1165 | 0.0558 | 0.1908 | 0.0883 | 0.2028 | 0.1403 | 0.1767 | 0.1589 | 0.1145 | 0.1608 | 0.0643 | 0.1673 | 0.0181 | 0.2119 | 0.0004 | 0.0007 | 0.0008 | 0.0010 | 0.0012 | 0.0042 | 0.0132 | 0.0178 | 0.0474 | 0.0437 | 0.0783 | 0.0615 | 0.0602 | 0.0612 | 0.0799 | 0.0829 | 0.7186 | 0.7269 | 0.0000 | 0.0000 | 0.0010 | 0.0011 | 0.0055 | 0.0056 | 0.0146 | 0.0202 | 0.0592 | 0.0633 | 0.0933 | 0.0959 | 0.0607 | 0.0774 | 0.0933 | 0.0970 | 0.6724 | 0.6396 | 0.0005 | 0.0000 | 0.0027 | 0.0140 | 0.0564 | 0.0794 | 0.0609 | 0.0947 | 0.6916 |
| MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 512 | 618 | | 11255 | 20255 | 428.2 | 87.05 | 105.63 | 203.30 | 309 | 354 | 384 | 408 | 429 | 449 | 474 | 501 | 549 | 0.0544 | 1102 | 0.683 | 111.73 | 25.46 | 6 | 0.0275 | 310 | 0.0009 | 22.99 | 7.263 | 0.2438 | 190902.0 | 88200000 | 42000000000 | 20600000000000 | 0.4424 | 0.2031 | 0.0003 | 0.0000 | 0.0008 | 0.0001 | 0.0026 | 0.0004 | 0.0084 | 0.0012 | 0.0280 | 0.0134 | 0.0584 | 0.0238 | 0.0474 | 0.0178 | 0.0713 | 0.0278 | 0.7829 | 0.9155 | 0.0001 | 0.0000 | 0.0003 | 0.0000 | 0.0008 | 0.0000 | 0.0033 | 0.0008 | 0.0135 | 0.0104 | 0.0281 | 0.0209 | 0.0204 | 0.0124 | 0.0313 | 0.0184 | 0.9022 | 0.9370 | 0.0011 | 0.0000 | 0.0063 | 0.0000 | 0.0110 | 0.0000 | 0.0226 | 0.0000 | 0.0479 | 0.0000 | 0.0805 | 0.0000 | 0.0642 | 0.0000 | 0.0789 | 0.0000 | 0.6875 | 0.0000 | 0.0009 | 0.0019 | 0.0058 | 0.0140 | 0.0333 | 0.0539 | 0.0552 | 0.0744 | 0.7606 | 8 | 9 | 10 | 11 | 13 | 16 | 42 | 145 | 378 | 0.0720 | 5.26 | 3.153 | 0.4465 | 52486.1 | 36900000 | 30400000000 | 27900000000000 | 0.5667 | 0.1091 | 0.0648 | 0.0042 | 0.2221 | 0.0305 | 0.2455 | 0.1491 | 0.1821 | 0.1574 | 0.1255 | 0.1533 | 0.0690 | 0.1678 | 0.0331 | 0.1262 | 0.0317 | 0.0846 | 0.0262 | 0.1269 | 0.0004 | 0.0000 | 0.0006 | 0.0006 | 0.0010 | 0.0017 | 0.0112 | 0.0092 | 0.0467 | 0.0430 | 0.0696 | 0.0628 | 0.0485 | 0.0415 | 0.0752 | 0.0685 | 0.7467 | 0.7729 | 0.0005 | 0.0005 | 0.0007 | 0.0007 | 0.0016 | 0.0025 | 0.0113 | 0.0152 | 0.0565 | 0.0539 | 0.0774 | 0.0786 | 0.0493 | 0.0607 | 0.0870 | 0.0851 | 0.7156 | 0.7027 | 0.0007 | 0.0000 | 0.0020 | 0.0119 | 0.0543 | 0.0701 | 0.0508 | 0.0795 | 0.7308 |
| MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 343 | 118 | | 16901 | 26398 | 141.3 | 44.30 | 218.23 | 252.21 | 94 | 105 | 114 | 123 | 132 | 143 | 157 | 175 | 204 | 0.0815 | 2151 | 0.681 | 101.95 | 26.17 | 6 | 0.0180 | 304 | 0.0015 | 29.37 | 6.914 | 0.2233 | 21941.5 | 3740000 | 696000000 | 140000000000 | 0.5305 | 0.1501 | 0.0011 | 0.0003 | 0.0048 | 0.0008 | 0.0158 | 0.0020 | 0.0410 | 0.0075 | 0.1072 | 0.0328 | 0.1650 | 0.0728 | 0.1666 | 0.0720 | 0.1890 | 0.1025 | 0.3095 | 0.7093 | 0.0006 | 0.0002 | 0.0026 | 0.0004 | 0.0058 | 0.0011 | 0.0146 | 0.0036 | 0.0408 | 0.0175 | 0.0693 | 0.0366 | 0.0679 | 0.0300 | 0.0954 | 0.0486 | 0.7030 | 0.8620 | 0.0021 | 0.0030 | 0.0070 | 0.0090 | 0.0120 | 0.0200 | 0.0527 | 0.0656 | 0.1020 | 0.1512 | 0.1411 | 0.1773 | 0.1049 | 0.1097 | 0.1331 | 0.1607 | 0.4451 | 0.3035 | 0.0015 | 0.0049 | 0.0131 | 0.0289 | 0.0754 | 0.1125 | 0.0940 | 0.1202 | 0.5495 | 20 | 29 | 48 | 79 | 120 | 175 | 259 | 375 | 570 | 0.0118 | 66.19 | 6.470 | 0.3644 | 111232.0 | 85900000 | 88000000000 | 113000000000000 | 0.5942 | 0.0903 | 0.0589 | 0.0022 | 0.1898 | 0.0187 | 0.2385 | 0.1095 | 0.1625 | 0.1457 | 0.1298 | 0.1893 | 0.1051 | 0.1818 | 0.0549 | 0.1192 | 0.0407 | 0.1100 | 0.0196 | 0.1236 | 0.0006 | 0.0005 | 0.0022 | 0.0016 | 0.0043 | 0.0051 | 0.0185 | 0.0152 | 0.0708 | 0.0630 | 0.1147 | 0.0979 | 0.0818 | 0.0754 | 0.1208 | 0.1064 | 0.5863 | 0.6349 | 0.0003 | 0.0018 | 0.0031 | 0.0043 | 0.0077 | 0.0110 | 0.0323 | 0.0372 | 0.0907 | 0.0969 | 0.1399 | 0.1479 | 0.1021 | 0.1013 | 0.1285 | 0.1341 | 0.4956 | 0.4656 | 0.0010 | 0.0025 | 0.0059 | 0.0245 | 0.0763 | 0.1324 | 0.0895 | 0.1228 | 0.5449 |
| Hs 578T | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 609 | 251 | | 8474 | 32235 | 492.3 | 132.68 | 164.80 | 304.29 | 304 | 403 | 447 | 478 | 505 | 531 | 562 | 596 | 642 | 0.0423 | 1362 | 0.553 | 103.04 | 22.02 | 6 | 0.0340 | 288 | 0.0004 | 114.84 | 8.011 | 0.1304 | 259967.0 | 144000000 | 83000000000 | 49400000000000 | 0.3722 | 0.2591 | 0.0000 | 0.0000 | 0.0008 | 0.0000 | 0.0037 | 0.0003 | 0.0143 | 0.0023 | 0.0499 | 0.0166 | 0.1100 | 0.0376 | 0.1112 | 0.0351 | 0.1452 | 0.0452 | 0.5648 | 0.8630 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0003 | 0.0001 | 0.0025 | 0.0009 | 0.0146 | 0.0117 | 0.0325 | 0.0201 | 0.0307 | 0.0127 | 0.0470 | 0.0181 | 0.8723 | 0.9363 | 0.0022 | 0.0048 | 0.0077 | 0.0143 | 0.0132 | 0.0286 | 0.0548 | 0.0835 | 0.1064 | 0.2124 | 0.1656 | 0.1742 | 0.1162 | 0.1074 | 0.1436 | 0.1480 | 0.3904 | 0.2267 | 0.0004 | 0.0024 | 0.0034 | 0.0209 | 0.0482 | 0.0869 | 0.0897 | 0.1054 | 0.6428 | 11 | 14 | 16 | 19 | 25 | 41 | 97 | 243 | 543 | 0.1744 | 25.68 | 4.127 | 0.6433 | 119746.0 | 132000000 | 179000000000 | 274000000000000 | 0.3012 | 0.3397 | 0.0899 | 0.0040 | 0.2395 | 0.0218 | 0.2653 | 0.1374 | 0.1444 | 0.1732 | 0.1091 | 0.1910 | 0.0818 | 0.1739 | 0.0413 | 0.1102 | 0.0177 | 0.0848 | 0.0111 | 0.1039 | 0.0005 | 0.0004 | 0.0016 | 0.0005 | 0.0018 | 0.0022 | 0.0158 | 0.0127 | 0.0501 | 0.0477 | 0.0704 | 0.0633 | 0.0461 | 0.0432 | 0.0696 | 0.0655 | 0.7443 | 0.7646 | 0.0003 | 0.0003 | 0.0003 | 0.0026 | 0.0043 | 0.0048 | 0.0182 | 0.0201 | 0.0595 | 0.0574 | 0.0778 | 0.0868 | 0.0553 | 0.0575 | 0.0768 | 0.0805 | 0.7076 | 0.6901 | 0.0004 | 0.0001 | 0.0031 | 0.0149 | 0.0534 | 0.0785 | 0.0435 | 0.0762 | 0.7299 |
| MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 880 | 885 | | 10209 | 13674 | 210.6 | 64.74 | 239.98 | 269.86 | 139 | 157 | 172 | 186 | 201 | 218 | 235 | 258 | 290 | 0.0808 | 1105 | 1.151 | 67.48 | 26.42 | 6 | 0.0172 | 176 | 0.0007 | 71.44 | 7.552 | 0.1615 | 48539.4 | 12300000 | 3450000000 | 1070000000000 | 0.4221 | 0.2180 | 0.0004 | 0.0000 | 0.0033 | 0.0003 | 0.0115 | 0.0010 | 0.0376 | 0.0028 | 0.1041 | 0.0279 | 0.1913 | 0.0622 | 0.1747 | 0.0675 | 0.1796 | 0.0979 | 0.2975 | 0.7403 | 0.0003 | 0.0000 | 0.0012 | 0.0000 | 0.0033 | 0.0005 | 0.0121 | 0.0017 | 0.0372 | 0.0177 | 0.0738 | 0.0313 | 0.0693 | 0.0305 | 0.0883 | 0.0432 | 0.7146 | 0.8751 | 0.0023 | 0.0091 | 0.0059 | 0.0136 | 0.0135 | 0.0385 | 0.0594 | 0.1145 | 0.1256 | 0.1531 | 0.1953 | 0.1803 | 0.1085 | 0.0918 | 0.1472 | 0.1168 | 0.3425 | 0.2823 | 0.0007 | 0.0027 | 0.0067 | 0.0258 | 0.0734 | 0.1232 | 0.1052 | 0.1252 | 0.5371 | 16 | 23 | 40 | 77 | 135 | 211 | 305 | 429 | 627 | 0.0143 | 119.92 | 6.776 | 0.3161 | 130409.0 | 96900000 | 85800000000 | 85400000000000 | 0.5316 | 0.1438 | 0.0357 | 0.0030 | 0.1564 | 0.0135 | 0.2778 | 0.0912 | 0.1687 | 0.1243 | 0.1317 | 0.1676 | 0.1036 | 0.1912 | 0.0617 | 0.1297 | 0.0418 | 0.1132 | 0.0226 | 0.1662 | 0.0003 | 0.0004 | 0.0016 | 0.0009 | 0.0038 | 0.0034 | 0.0135 | 0.0085 | 0.0587 | 0.0479 | 0.1129 | 0.0936 | 0.0741 | 0.0654 | 0.1097 | 0.0915 | 0.6255 | 0.6882 | 0.0009 | 0.0013 | 0.0032 | 0.0051 | 0.0090 | 0.0105 | 0.0254 | 0.0239 | 0.0757 | 0.0826 | 0.1232 | 0.1313 | 0.0868 | 0.0987 | 0.1179 | 0.1229 | 0.5578 | 0.5235 | 0.0000 | 0.0022 | 0.0066 | 0.0179 | 0.0664 | 0.1252 | 0.0814 | 0.1093 | 0.5910 |
| SK-BR-3 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 981 | 384 | | 5976 | 15063 | 375.2 | 139.04 | 87.22 | 138.43 | 122 | 252 | 332 | 379 | 411 | 436 | 459 | 488 | 529 | 0.0690 | 1040 | 1.006 | 89.27 | 27.02 | 6 | 0.0370 | 221 | 0.0008 | 30.99 | 7.402 | 0.2347 | 160087.0 | 72700000 | 34300000000 | 16600000000000 | 0.3898 | 0.2387 | 0.0000 | 0.0007 | 0.0017 | 0.0002 | 0.0067 | 0.0009 | 0.0168 | 0.0037 | 0.0750 | 0.0273 | 0.1215 | 0.0375 | 0.1056 | 0.0371 | 0.1567 | 0.0526 | 0.5159 | 0.8400 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0011 | 0.0010 | 0.0162 | 0.0143 | 0.0270 | 0.0202 | 0.0191 | 0.0149 | 0.0299 | 0.0212 | 0.9067 | 0.9283 | 0.0010 | 0.0079 | 0.0044 | 0.0111 | 0.0092 | 0.0142 | 0.0247 | 0.0190 | 0.0499 | 0.0774 | 0.0727 | 0.0900 | 0.0751 | 0.0979 | 0.0931 | 0.1327 | 0.6699 | 0.5498 | 0.0000 | 0.0000 | 0.0003 | 0.0047 | 0.0261 | 0.0387 | 0.0368 | 0.0506 | 0.8428 | 6 | 9 | 12 | 16 | 25 | 42 | 68 | 128 | 272 | 0.0676 | 12.92 | 4.513 | 0.5910 | 26768.0 | 12200000 | 6560000000 | 3860000000000 | 0.6432 | 0.1082 | 0.0291 | 0.0037 | 0.1315 | 0.0140 | 0.2008 | 0.0494 | 0.1526 | 0.1090 | 0.1345 | 0.1747 | 0.1305 | 0.1850 | 0.0723 | 0.1072 | 0.0773 | 0.1235 | 0.0713 | 0.2335 | 0.0004 | 0.0011 | 0.0020 | 0.0030 | 0.0027 | 0.0032 | 0.0162 | 0.0112 | 0.0605 | 0.0539 | 0.0900 | 0.0723 | 0.0693 | 0.0632 | 0.0924 | 0.0883 | 0.6664 | 0.7038 | 0.0017 | 0.0010 | 0.0017 | 0.0041 | 0.0049 | 0.0073 | 0.0171 | 0.0188 | 0.0713 | 0.0786 | 0.0991 | 0.0958 | 0.0739 | 0.0856 | 0.1026 | 0.1117 | 0.6275 | 0.5969 | 0.0016 | 0.0028 | 0.0041 | 0.0173 | 0.0693 | 0.0929 | 0.0745 | 0.0962 | 0.6412 |
| MDA-MB-231 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 469 | 438 | | 2983 | 6904 | 291.5 | 155.73 | 25.80 | 36.51 | 163 | 179 | 192 | 210 | 232 | 259 | 292 | 423 | 579 | 0.1047 | 723 | 0.563 | 78.24 | 21.26 | 5 | 0.0865 | 258 | 0.0031 | 12.41 | 6.310 | 0.3653 | 109220.0 | 50500000 | 26800000000 | 15300000000000 | 0.4115 | 0.2245 | 0.0013 | 0.0000 | 0.0013 | 0.0011 | 0.0053 | 0.0049 | 0.0279 | 0.0152 | 0.0810 | 0.0455 | 0.1514 | 0.0829 | 0.1142 | 0.0650 | 0.1116 | 0.0861 | 0.5060 | 0.6994 | 0.0007 | 0.0000 | 0.0007 | 0.0008 | 0.0027 | 0.0036 | 0.0129 | 0.0101 | 0.0278 | 0.0283 | 0.0394 | 0.0449 | 0.0455 | 0.0377 | 0.0502 | 0.0494 | 0.8201 | 0.8251 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0042 | 0.0048 | 0.0250 | 0.0353 | 0.0722 | 0.0609 | 0.0222 | 0.0304 | 0.0431 | 0.0529 | 0.8333 | 0.8157 | 0.0000 | 0.0022 | 0.0078 | 0.0100 | 0.0288 | 0.0654 | 0.0310 | 0.0488 | 0.8060 | 7 | 9 | 10 | 12 | 14 | 17 | 22 | 30 | 49 | 0.1051 | 1.66 | 3.110 | 0.7374 | 1998.1 | 320182 | 69200000 | 17600000000 | 0.5249 | 0.1326 | 0.0229 | 0.0158 | 0.0439 | 0.0273 | 0.0768 | 0.0379 | 0.1286 | 0.0532 | 0.1655 | 0.0873 | 0.1864 | 0.1237 | 0.1685 | 0.1324 | 0.1256 | 0.1938 | 0.0818 | 0.3285 | 0.0053 | 0.0100 | 0.0107 | 0.0158 | 0.0191 | 0.0197 | 0.0364 | 0.0262 | 0.0631 | 0.0494 | 0.1039 | 0.0862 | 0.0795 | 0.0733 | 0.0955 | 0.1172 | 0.5866 | 0.6021 | 0.0056 | 0.0129 | 0.0104 | 0.0069 | 0.0288 | 0.0247 | 0.0400 | 0.0366 | 0.0737 | 0.0791 | 0.1017 | 0.1098 | 0.0745 | 0.0692 | 0.1129 | 0.0930 | 0.5524 | 0.5678 | 0.0070 | 0.0152 | 0.0275 | 0.0427 | 0.0719 | 0.1029 | 0.0830 | 0.0918 | 0.5582 |
| Hs 578T | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 960 | 785 | | 14324 | 30146 | 220.1 | 48.30 | 124.97 | 184.42 | 157 | 180 | 197 | 210 | 222 | 234 | 246 | 262 | 280 | 0.0506 | 1525 | 1.218 | 105.55 | 39.82 | 5 | 0.0186 | 266 | 0.0010 | 36.62 | 7.236 | 0.1928 | 50767.5 | 12200000 | 3020000000 | 771000000000 | 0.3776 | 0.2614 | 0.0006 | 0.0000 | 0.0007 | 0.0000 | 0.0054 | 0.0001 | 0.0194 | 0.0010 | 0.0554 | 0.0114 | 0.1099 | 0.0262 | 0.1289 | 0.0281 | 0.1632 | 0.0425 | 0.5166 | 0.8907 | 0.0003 | 0.0000 | 0.0001 | 0.0000 | 0.0019 | 0.0000 | 0.0064 | 0.0003 | 0.0181 | 0.0084 | 0.0357 | 0.0167 | 0.0450 | 0.0127 | 0.0607 | 0.0189 | 0.8318 | 0.9430 | 0.0040 | 0.0182 | 0.0081 | 0.0286 | 0.0316 | 0.0909 | 0.0683 | 0.1506 | 0.1278 | 0.2052 | 0.1725 | 0.1740 | 0.1366 | 0.1117 | 0.1490 | 0.1039 | 0.3021 | 0.1169 | 0.0009 | 0.0031 | 0.0069 | 0.0208 | 0.0550 | 0.0930 | 0.1034 | 0.1315 | 0.5854 | 12 | 15 | 19 | 26 | 43 | 72 | 121 | 198 | 355 | 0.0673 | 18.66 | 4.787 | 0.5693 | 49625.5 | 32400000 | 28000000000 | 29100000000000 | 0.5089 | 0.1429 | 0.0634 | 0.0024 | 0.1947 | 0.0244 | 0.2245 | 0.1272 | 0.1694 | 0.1268 | 0.1346 | 0.1704 | 0.0969 | 0.1796 | 0.0580 | 0.1221 | 0.0414 | 0.1040 | 0.0170 | 0.1433 | 0.0006 | 0.0003 | 0.0017 | 0.0012 | 0.0033 | 0.0024 | 0.0152 | 0.0164 | 0.0709 | 0.0583 | 0.1015 | 0.0909 | 0.0701 | 0.0625 | 0.1026 | 0.0863 | 0.6341 | 0.6818 | 0.0001 | 0.0007 | 0.0023 | 0.0034 | 0.0068 | 0.0081 | 0.0275 | 0.0324 | 0.0863 | 0.0889 | 0.1257 | 0.1296 | 0.0840 | 0.0940 | 0.1076 | 0.1098 | 0.5596 | 0.5331 | 0.0005 | 0.0014 | 0.0043 | 0.0212 | 0.0766 | 0.1127 | 0.0825 | 0.1069 | 0.5940 |
| Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1226 | 292 | | 1447 | 9024 | 65.1 | 24.28 | 181.44 | 210.82 | 35 | 44 | 51 | 57 | 63 | 69 | 76 | 85 | 96 | 0.0659 | 595 | 0.521 | 83.49 | 16.03 | 5 | 0.1714 | 248 | 0.0021 | 31.10 | 6.361 | 0.2003 | 4823.6 | 400876 | 37000000 | 3760000000 | 0.3867 | 0.2406 | 0.0000 | 0.0000 | 0.0116 | 0.0000 | 0.0198 | 0.0028 | 0.0843 | 0.0170 | 0.1802 | 0.0405 | 0.2215 | 0.1008 | 0.1884 | 0.1329 | 0.1818 | 0.1951 | 0.1124 | 0.5108 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0020 | 0.0016 | 0.0109 | 0.0095 | 0.0465 | 0.0247 | 0.0812 | 0.0366 | 0.0663 | 0.0461 | 0.1238 | 0.0700 | 0.6693 | 0.8115 | 0.0049 | 0.0255 | 0.0099 | 0.0204 | 0.0025 | 0.0510 | 0.0765 | 0.1071 | 0.1284 | 0.1837 | 0.1778 | 0.1735 | 0.1654 | 0.1173 | 0.1407 | 0.1378 | 0.2938 | 0.1837 | 0.0015 | 0.0029 | 0.0059 | 0.0322 | 0.1025 | 0.1259 | 0.1127 | 0.1347 | 0.4817 | 19 | 26 | 41 | 64 | 97 | 142 | 205 | 308 | 477 | 0.0338 | 9.96 | 5.000 | 0.5659 | 77361.5 | 47900000 | 36100000000 | 30600000000000 | 0.5191 | 0.1524 | 0.0220 | 0.0015 | 0.0828 | 0.0094 | 0.1118 | 0.0342 | 0.1577 | 0.0768 | 0.2126 | 0.1412 | 0.1427 | 0.1684 | 0.1228 | 0.1273 | 0.0918 | 0.1446 | 0.0559 | 0.2967 | 0.0006 | 0.0005 | 0.0025 | 0.0012 | 0.0034 | 0.0009 | 0.0104 | 0.0092 | 0.0533 | 0.0431 | 0.0855 | 0.0726 | 0.0676 | 0.0528 | 0.0917 | 0.0820 | 0.6851 | 0.7378 | 0.0008 | 0.0013 | 0.0027 | 0.0022 | 0.0059 | 0.0040 | 0.0164 | 0.0211 | 0.0632 | 0.0723 | 0.1096 | 0.1159 | 0.0780 | 0.0858 | 0.1166 | 0.1204 | 0.6069 | 0.5768 | 0.0003 | 0.0020 | 0.0043 | 0.0143 | 0.0627 | 0.0953 | 0.0720 | 0.1040 | 0.6450 |
| Hs 578T | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 487 | 388 | | 17803 | 45389 | 157.0 | 50.28 | 154.36 | 177.24 | 92 | 114 | 128 | 142 | 155 | 168 | 183 | 200 | 225 | 0.0425 | 1928 | 1.251 | 24.52 | 7.81 | 5 | 0.0033 | 58 | 0.0011 | 27.12 | 7.140 | 0.2383 | 27189.4 | 5090000 | 1010000000 | 213000000000 | 0.4282 | 0.2106 | 0.0016 | 0.0001 | 0.0027 | 0.0011 | 0.0080 | 0.0022 | 0.0288 | 0.0083 | 0.0923 | 0.0292 | 0.1552 | 0.0530 | 0.1536 | 0.0615 | 0.1813 | 0.0892 | 0.3764 | 0.7554 | 0.0006 | 0.0001 | 0.0008 | 0.0008 | 0.0020 | 0.0012 | 0.0062 | 0.0038 | 0.0238 | 0.0118 | 0.0466 | 0.0193 | 0.0520 | 0.0202 | 0.0673 | 0.0299 | 0.8006 | 0.9130 | 0.0028 | 0.0076 | 0.0051 | 0.0076 | 0.0145 | 0.0286 | 0.0373 | 0.0753 | 0.0821 | 0.1201 | 0.1345 | 0.1711 | 0.1117 | 0.1287 | 0.1381 | 0.1368 | 0.4740 | 0.3241 | 0.0009 | 0.0019 | 0.0057 | 0.0186 | 0.0505 | 0.0897 | 0.0859 | 0.1121 | 0.6346 | 13 | 18 | 26 | 47 | 81 | 128 | 193 | 278 | 407 | 0.0395 | 20.75 | 5.394 | 0.5005 | 55240.7 | 27700000 | 16900000000 | 11900000000000 | 0.4247 | 0.2143 | 0.0378 | 0.0014 | 0.1492 | 0.0110 | 0.2622 | 0.0683 | 0.1893 | 0.1171 | 0.1504 | 0.1913 | 0.1095 | 0.1978 | 0.0586 | 0.1383 | 0.0341 | 0.1296 | 0.0088 | 0.1451 | 0.0003 | 0.0002 | 0.0011 | 0.0008 | 0.0022 | 0.0018 | 0.0130 | 0.0095 | 0.0518 | 0.0406 | 0.0919 | 0.0720 | 0.0661 | 0.0535 | 0.0987 | 0.0822 | 0.6750 | 0.7394 | 0.0006 | 0.0006 | 0.0012 | 0.0024 | 0.0051 | 0.0080 | 0.0184 | 0.0254 | 0.0735 | 0.0834 | 0.1248 | 0.1314 | 0.0862 | 0.0949 | 0.1190 | 0.1284 | 0.5712 | 0.5254 | 0.0004 | 0.0015 | 0.0030 | 0.0169 | 0.0596 | 0.1071 | 0.0813 | 0.1092 | 0.6210 |
| MDA-MB-231 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 347 | 300 | | 2888 | 7129 | 611.2 | 202.03 | 52.68 | 78.44 | 344 | 415 | 484 | 545 | 608 | 668 | 727 | 793 | 895 | 0.0933 | 665 | 0.692 | 73.88 | 19.31 | 5 | 0.0793 | 229 | 0.0006 | 88.70 | 7.545 | 0.1281 | 414341.0 | 304000000 | 237000000000 | 194000000000000 | 0.4195 | 0.2137 | 0.0000 | 0.0000 | 0.0009 | 0.0000 | 0.0017 | 0.0014 | 0.0318 | 0.0028 | 0.1133 | 0.0503 | 0.2017 | 0.0878 | 0.1279 | 0.0617 | 0.1536 | 0.0897 | 0.3691 | 0.7061 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0005 | 0.0008 | 0.0040 | 0.0012 | 0.0334 | 0.0335 | 0.0703 | 0.0467 | 0.0389 | 0.0283 | 0.0573 | 0.0463 | 0.7956 | 0.8432 | 0.0024 | 0.0000 | 0.0012 | 0.0050 | 0.0071 | 0.0075 | 0.0214 | 0.0150 | 0.0820 | 0.1075 | 0.1023 | 0.1425 | 0.0880 | 0.0650 | 0.0892 | 0.1175 | 0.6064 | 0.5400 | 0.0000 | 0.0000 | 0.0000 | 0.0077 | 0.0510 | 0.0944 | 0.0573 | 0.0839 | 0.7056 | 9 | 12 | 14 | 18 | 24 | 33 | 47 | 68 | 122 | 0.0416 | 14.75 | 4.364 | 0.5754 | 8927.3 | 2850000 | 1210000000 | 606000000000 | 0.5155 | 0.1457 | 0.0091 | 0.0030 | 0.0653 | 0.0089 | 0.1554 | 0.0244 | 0.2324 | 0.0654 | 0.1932 | 0.1426 | 0.1436 | 0.1717 | 0.1097 | 0.1794 | 0.0627 | 0.1747 | 0.0287 | 0.2299 | 0.0004 | 0.0014 | 0.0052 | 0.0037 | 0.0100 | 0.0071 | 0.0247 | 0.0216 | 0.0715 | 0.0632 | 0.1001 | 0.0781 | 0.0811 | 0.0784 | 0.1188 | 0.1055 | 0.5882 | 0.6410 | 0.0013 | 0.0024 | 0.0084 | 0.0102 | 0.0149 | 0.0071 | 0.0292 | 0.0314 | 0.0876 | 0.0949 | 0.1181 | 0.1459 | 0.0876 | 0.0933 | 0.1207 | 0.1231 | 0.5321 | 0.4918 | 0.0016 | 0.0058 | 0.0111 | 0.0329 | 0.0853 | 0.1081 | 0.0859 | 0.1171 | 0.5522 |
| MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 470 | 334 | | 17082 | 34713 | 121.5 | 40.86 | 150.26 | 149.90 | 78 | 87 | 96 | 104 | 113 | 124 | 137 | 153 | 176 | 0.0613 | 2127 | 0.917 | 53.45 | 21.26 | 5 | 0.0091 | 155 | 0.0008 | 47.08 | 7.438 | 0.1848 | 16426.1 | 2470000 | 412000000 | 75400000000 | 0.5115 | 0.1584 | 0.0012 | 0.0001 | 0.0040 | 0.0001 | 0.0120 | 0.0016 | 0.0473 | 0.0092 | 0.1219 | 0.0386 | 0.1808 | 0.0802 | 0.1691 | 0.0807 | 0.1727 | 0.1152 | 0.2911 | 0.6742 | 0.0005 | 0.0001 | 0.0019 | 0.0001 | 0.0033 | 0.0009 | 0.0140 | 0.0056 | 0.0416 | 0.0205 | 0.0689 | 0.0420 | 0.0618 | 0.0336 | 0.0900 | 0.0533 | 0.7179 | 0.8439 | 0.0012 | 0.0043 | 0.0043 | 0.0104 | 0.0127 | 0.0293 | 0.0437 | 0.0804 | 0.1009 | 0.1268 | 0.1386 | 0.1608 | 0.1105 | 0.1154 | 0.1410 | 0.1334 | 0.4469 | 0.3392 | 0.0011 | 0.0023 | 0.0098 | 0.0256 | 0.0655 | 0.1021 | 0.0917 | 0.1081 | 0.5939 | 13 | 20 | 40 | 73 | 109 | 146 | 192 | 255 | 354 | 0.0246 | 17.30 | 5.572 | 0.4804 | 45049.4 | 19600000 | 11700000000 | 9560000000000 | 0.5599 | 0.1198 | 0.0163 | 0.0018 | 0.0736 | 0.0061 | 0.1603 | 0.0328 | 0.1540 | 0.0660 | 0.1820 | 0.1370 | 0.1647 | 0.1862 | 0.1066 | 0.1461 | 0.0830 | 0.1520 | 0.0595 | 0.2718 | 0.0002 | 0.0004 | 0.0015 | 0.0006 | 0.0032 | 0.0019 | 0.0118 | 0.0080 | 0.0480 | 0.0350 | 0.0826 | 0.0652 | 0.0678 | 0.0531 | 0.0929 | 0.0754 | 0.6920 | 0.7604 | 0.0006 | 0.0013 | 0.0019 | 0.0026 | 0.0068 | 0.0081 | 0.0218 | 0.0295 | 0.0745 | 0.0894 | 0.1255 | 0.1446 | 0.0963 | 0.1068 | 0.1258 | 0.1351 | 0.5468 | 0.4826 | 0.0005 | 0.0014 | 0.0039 | 0.0169 | 0.0590 | 0.1040 | 0.0801 | 0.1148 | 0.6194 |
| MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 170 | 550 | | 8750 | 8424 | 502.4 | 87.96 | 41.36 | 73.23 | 382 | 421 | 449 | 477 | 504 | 533 | 561 | 587 | 616 | 0.0991 | 835 | 0.776 | 84.48 | 24.52 | 5 | 0.0277 | 242 | 0.0010 | 31.96 | 7.187 | 0.2170 | 260103.0 | 138000000 | 75400000000 | 41900000000000 | 0.4172 | 0.2234 | 0.0005 | 0.0000 | 0.0021 | 0.0000 | 0.0032 | 0.0000 | 0.0111 | 0.0005 | 0.0476 | 0.0114 | 0.0760 | 0.0187 | 0.0904 | 0.0131 | 0.1317 | 0.0244 | 0.6373 | 0.9319 | 0.0003 | 0.0000 | 0.0001 | 0.0000 | 0.0008 | 0.0000 | 0.0043 | 0.0005 | 0.0214 | 0.0113 | 0.0331 | 0.0183 | 0.0365 | 0.0119 | 0.0525 | 0.0214 | 0.8509 | 0.9367 | 0.0126 | 0.1000 | 0.0126 | 0.2000 | 0.0356 | 0.5000 | 0.0617 | 0.2000 | 0.1146 | 0.0000 | 0.1486 | 0.0000 | 0.1328 | 0.0000 | 0.1518 | 0.0000 | 0.3296 | 0.0000 | 0.0014 | 0.0023 | 0.0063 | 0.0160 | 0.0405 | 0.0657 | 0.0673 | 0.0822 | 0.7184 | 8 | 10 | 12 | 13 | 16 | 20 | 28 | 44 | 98 | 0.1584 | 2.61 | 3.052 | 0.7597 | 7073.0 | 2420000 | 1080000000 | 547000000000 | 0.6438 | 0.0750 | 0.0266 | 0.0119 | 0.0620 | 0.0252 | 0.1004 | 0.0365 | 0.1492 | 0.0697 | 0.1905 | 0.1048 | 0.1418 | 0.1287 | 0.1536 | 0.1301 | 0.0960 | 0.1858 | 0.0798 | 0.3072 | 0.0055 | 0.0063 | 0.0104 | 0.0116 | 0.0127 | 0.0137 | 0.0209 | 0.0256 | 0.0563 | 0.0460 | 0.0700 | 0.0674 | 0.0691 | 0.0593 | 0.1004 | 0.1092 | 0.6547 | 0.6608 | 0.0000 | 0.0045 | 0.0052 | 0.0037 | 0.0085 | 0.0082 | 0.0184 | 0.0231 | 0.0636 | 0.0723 | 0.0932 | 0.0835 | 0.0636 | 0.0776 | 0.1122 | 0.1148 | 0.6352 | 0.6122 | 0.0011 | 0.0038 | 0.0098 | 0.0235 | 0.0573 | 0.0742 | 0.0770 | 0.1070 | 0.6463 |
| MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1025 | 533 | | 6415 | 17497 | 136.2 | 34.04 | 109.48 | 103.79 | 91 | 104 | 115 | 126 | 135 | 145 | 155 | 165 | 181 | 0.0768 | 1343 | 1.143 | 110.98 | 37.59 | 5 | 0.0415 | 266 | 0.0020 | 17.74 | 6.447 | 0.2724 | 19709.7 | 3010000 | 484000000 | 81300000000 | 0.4281 | 0.2171 | 0.0017 | 0.0000 | 0.0060 | 0.0009 | 0.0083 | 0.0029 | 0.0252 | 0.0062 | 0.0809 | 0.0210 | 0.1181 | 0.0496 | 0.1378 | 0.0503 | 0.1704 | 0.0722 | 0.4515 | 0.7970 | 0.0002 | 0.0000 | 0.0023 | 0.0005 | 0.0016 | 0.0016 | 0.0072 | 0.0042 | 0.0297 | 0.0146 | 0.0462 | 0.0299 | 0.0467 | 0.0256 | 0.0632 | 0.0341 | 0.8029 | 0.8896 | 0.0050 | 0.0107 | 0.0137 | 0.0134 | 0.0281 | 0.0588 | 0.0518 | 0.1070 | 0.0978 | 0.1765 | 0.1259 | 0.2005 | 0.1295 | 0.1150 | 0.1489 | 0.1283 | 0.3993 | 0.1898 | 0.0003 | 0.0025 | 0.0041 | 0.0194 | 0.0484 | 0.0871 | 0.0787 | 0.1052 | 0.6544 | 23 | 35 | 46 | 58 | 72 | 92 | 123 | 171 | 248 | 0.0137 | 12.49 | 5.314 | 0.4876 | 22756.3 | 7180000 | 2950000000 | 1450000000000 | 0.5455 | 0.1639 | 0.0152 | 0.0037 | 0.0629 | 0.0119 | 0.1464 | 0.0290 | 0.2021 | 0.0594 | 0.2186 | 0.1394 | 0.1738 | 0.1927 | 0.0924 | 0.1541 | 0.0557 | 0.1495 | 0.0329 | 0.2603 | 0.0008 | 0.0018 | 0.0032 | 0.0044 | 0.0073 | 0.0078 | 0.0221 | 0.0165 | 0.0575 | 0.0523 | 0.0972 | 0.0769 | 0.0694 | 0.0675 | 0.0930 | 0.0837 | 0.6497 | 0.6889 | 0.0020 | 0.0015 | 0.0045 | 0.0037 | 0.0134 | 0.0110 | 0.0213 | 0.0282 | 0.0764 | 0.0849 | 0.1103 | 0.1288 | 0.0855 | 0.0952 | 0.1156 | 0.1242 | 0.5710 | 0.5225 | 0.0015 | 0.0052 | 0.0074 | 0.0247 | 0.0649 | 0.1051 | 0.0778 | 0.1034 | 0.6100 |
| MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 740 | 703 | | 8862 | 18824 | 530.1 | 80.43 | 114.15 | 251.56 | 421 | 467 | 496 | 517 | 535 | 553 | 573 | 598 | 631 | 0.0548 | 1032 | 0.545 | 114.22 | 22.67 | 5 | 0.0372 | 330 | 0.0009 | 38.41 | 7.314 | 0.2073 | 287452.0 | 159000000 | 89500000000 | 51200000000000 | 0.4491 | 0.2025 | 0.0001 | 0.0000 | 0.0006 | 0.0000 | 0.0007 | 0.0001 | 0.0056 | 0.0007 | 0.0282 | 0.0139 | 0.0564 | 0.0200 | 0.0512 | 0.0144 | 0.0715 | 0.0211 | 0.7858 | 0.9298 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0001 | 0.0016 | 0.0007 | 0.0179 | 0.0139 | 0.0306 | 0.0200 | 0.0252 | 0.0144 | 0.0335 | 0.0202 | 0.8913 | 0.9307 | 0.0075 | 1.0000 | 0.0188 | 0.0000 | 0.0225 | 0.0000 | 0.0476 | 0.0000 | 0.1164 | 0.0000 | 0.1640 | 0.0000 | 0.1014 | 0.0000 | 0.1502 | 0.0000 | 0.3717 | 0.0000 | 0.0006 | 0.0036 | 0.0074 | 0.0181 | 0.0434 | 0.0613 | 0.0734 | 0.0863 | 0.7059 | 9 | 10 | 12 | 13 | 15 | 20 | 38 | 121 | 352 | 0.1429 | 9.00 | 3.049 | 0.5952 | 76308.2 | 79500000 | 99600000000 | 139000000000000 | 0.5235 | 0.1294 | 0.0259 | 0.0023 | 0.0761 | 0.0164 | 0.2120 | 0.0561 | 0.1942 | 0.0865 | 0.2006 | 0.1645 | 0.1003 | 0.2050 | 0.1036 | 0.1458 | 0.0631 | 0.1341 | 0.0243 | 0.1894 | 0.0000 | 0.0004 | 0.0002 | 0.0004 | 0.0012 | 0.0011 | 0.0067 | 0.0072 | 0.0396 | 0.0383 | 0.0538 | 0.0475 | 0.0401 | 0.0385 | 0.0569 | 0.0591 | 0.8015 | 0.8073 | 0.0003 | 0.0000 | 0.0006 | 0.0006 | 0.0017 | 0.0021 | 0.0056 | 0.0079 | 0.0476 | 0.0539 | 0.0673 | 0.0667 | 0.0437 | 0.0521 | 0.0707 | 0.0758 | 0.7625 | 0.7409 | 0.0000 | 0.0005 | 0.0016 | 0.0065 | 0.0428 | 0.0586 | 0.0418 | 0.0664 | 0.7819 |
| MDA-MB-231 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 1132 | 783 | | 5806 | 15602 | 539.4 | 203.19 | 87.63 | 159.39 | 237 | 320 | 418 | 529 | 593 | 630 | 664 | 708 | 771 | 0.0657 | 1025 | 0.615 | 160.90 | 32.02 | 5 | 0.0725 | 421 | 0.0005 | 70.80 | 7.812 | 0.1691 | 332268.0 | 221000000 | 155000000000 | 113000000000000 | 0.4107 | 0.2133 | 0.0000 | 0.0000 | 0.0015 | 0.0005 | 0.0067 | 0.0003 | 0.0370 | 0.0061 | 0.1090 | 0.0389 | 0.1697 | 0.0718 | 0.1398 | 0.0509 | 0.1506 | 0.0799 | 0.3856 | 0.7517 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0035 | 0.0013 | 0.0213 | 0.0203 | 0.0424 | 0.0428 | 0.0263 | 0.0197 | 0.0354 | 0.0324 | 0.8711 | 0.8834 | 0.0015 | 0.0000 | 0.0078 | 0.0000 | 0.0069 | 0.0000 | 0.0206 | 0.0000 | 0.0553 | 0.0000 | 0.0852 | 0.0000 | 0.0715 | 0.0000 | 0.0832 | 0.0000 | 0.6681 | 1.0000 | 0.0003 | 0.0000 | 0.0003 | 0.0038 | 0.0262 | 0.0487 | 0.0324 | 0.0461 | 0.8422 | 6 | 8 | 9 | 11 | 14 | 23 | 51 | 120 | 297 | 0.1136 | 5.25 | 3.423 | 0.5908 | 33081.1 | 18000000 | 11400000000 | 7790000000000 | 0.5377 | 0.1183 | 0.0619 | 0.0026 | 0.1417 | 0.0166 | 0.2366 | 0.0806 | 0.1761 | 0.1157 | 0.1747 | 0.1905 | 0.0894 | 0.2027 | 0.0688 | 0.1381 | 0.0303 | 0.1234 | 0.0206 | 0.1298 | 0.0010 | 0.0002 | 0.0007 | 0.0002 | 0.0020 | 0.0017 | 0.0110 | 0.0119 | 0.0483 | 0.0430 | 0.0841 | 0.0733 | 0.0507 | 0.0497 | 0.0741 | 0.0696 | 0.7281 | 0.7502 | 0.0003 | 0.0007 | 0.0012 | 0.0036 | 0.0056 | 0.0029 | 0.0148 | 0.0180 | 0.0545 | 0.0546 | 0.0898 | 0.0971 | 0.0634 | 0.0605 | 0.0756 | 0.0840 | 0.6947 | 0.6788 | 0.0003 | 0.0005 | 0.0038 | 0.0110 | 0.0513 | 0.0880 | 0.0548 | 0.0784 | 0.7120 |
| MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 568 | 142 | | 3390 | 3676 | 488.2 | 76.89 | 55.99 | 95.47 | 384 | 420 | 448 | 473 | 493 | 513 | 533 | 556 | 587 | 0.1317 | 484 | 0.859 | 109.18 | 23.32 | 5 | 0.0752 | 255 | 0.0012 | 41.51 | 6.959 | 0.2091 | 244289.0 | 125000000 | 65200000000 | 34600000000000 | 0.4456 | 0.2022 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0019 | 0.0000 | 0.0133 | 0.0009 | 0.0451 | 0.0139 | 0.0863 | 0.0237 | 0.0833 | 0.0160 | 0.1064 | 0.0261 | 0.6638 | 0.9194 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0050 | 0.0009 | 0.0220 | 0.0139 | 0.0441 | 0.0237 | 0.0414 | 0.0154 | 0.0588 | 0.0231 | 0.8284 | 0.9230 | 0.0028 | 0.0000 | 0.0113 | 1.0000 | 0.0395 | 0.0000 | 0.1073 | 0.0000 | 0.1638 | 0.0000 | 0.2147 | 0.0000 | 0.1243 | 0.0000 | 0.1356 | 0.0000 | 0.2006 | 0.0000 | 0.0006 | 0.0017 | 0.0045 | 0.0195 | 0.0658 | 0.1155 | 0.1016 | 0.1267 | 0.5642 | 9 | 11 | 12 | 14 | 17 | 20 | 25 | 75 | 169 | 0.1554 | 6.68 | 3.147 | 0.7267 | 12247.2 | 4240000 | 1770000000 | 834000000000 | 0.4752 | 0.1492 | 0.0192 | 0.0284 | 0.0769 | 0.0355 | 0.1731 | 0.1277 | 0.3462 | 0.1489 | 0.1346 | 0.1915 | 0.1346 | 0.1773 | 0.1154 | 0.1206 | 0.0000 | 0.0709 | 0.0000 | 0.0993 | 0.0000 | 0.0046 | 0.0025 | 0.0058 | 0.0012 | 0.0116 | 0.0037 | 0.0127 | 0.0160 | 0.0197 | 0.0197 | 0.0313 | 0.0271 | 0.0174 | 0.0406 | 0.0440 | 0.8892 | 0.8530 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0026 | 0.0028 | 0.0039 | 0.0083 | 0.0211 | 0.0221 | 0.0316 | 0.0456 | 0.0395 | 0.0415 | 0.0684 | 0.0692 | 0.8329 | 0.8105 | 0.0000 | 0.0000 | 0.0013 | 0.0038 | 0.0189 | 0.0215 | 0.0278 | 0.0556 | 0.8712 |