High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)

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Cell SM Name Small Mol Concentration Small Mol Conc Unit Other Reagent 1 Name Other Reagent 1 Detection Channel Other Reagent 2 Name Other Reagent 2 Detection Channel Row Column Field X-coordinate Y-coordinate Image Nuclear area (pixels) Cytoplasm area (pixels) Nuclear intensity (AU) Std Dev of nuclear intensity (AU) Cytoplasm intensity (AU) Std Dev of cytoplasm intensity (AU) 10% quantile of nuclear intensity (AU) 20% quantile of nuclear intensity (AU) 30% quantile of nuclear intensity (AU) 40% quantile of nuclear intensity (AU) 50% quantile of nuclear intensity (AU) 60% quantile of nuclear intensity (AU) 70% quantile of nuclear intensity (AU) 80% quantile of nuclear intensity (AU) 90% quantile of nuclear intensity (AU) Ratio of cytoplasm perimeter to area Cytoplasm perimeter (pixels) Nuclear roundness Nuclear length (pixels) Nuclear halfwidth (pixels) Number of nuclei Ratio of nuclear perimeter to area Nuclear perimeter (pixels) Nuclear Haralick ASM Nuclear Haralick contrast Nuclear Haralick entropy Nuclear Haralick IDM Nuclear Haralick moment 2 Nuclear Haralick moment 3 Nuclear Haralick moment 4 Nuclear Haralick moment 5 Nuclear radial moment (border) Nuclear radial moment (center) Nuclear Threshold Adj Stat 1 (Threshold: 0.2) Nuclear Threshold Adj Stat 1 (Threshold: 0.4) Nuclear Threshold Adj Stat 2 (Threshold: 0.2) Nuclear Threshold Adj Stat 2 (Threshold: 0.4) Nuclear Threshold Adj Stat 3 (Threshold: 0.2) Nuclear Threshold Adj Stat 3 (Threshold: 0.4) Nuclear Threshold Adj Stat 4 (Threshold: 0.2) Nuclear Threshold Adj Stat 4 (Threshold: 0.4) Nuclear Threshold Adj Stat 5 (Threshold: 0.2) Nuclear Threshold Adj Stat 5 (Threshold: 0.4) Nuclear Threshold Adj Stat 6 (Threshold: 0.2) Nuclear Threshold Adj Stat 6 (Threshold: 0.4) Nuclear Threshold Adj Stat 7 (Threshold: 0.2) Nuclear Threshold Adj Stat 7 (Threshold: 0.4) Nuclear Threshold Adj Stat 8 (Threshold: 0.2) Nuclear Threshold Adj Stat 8 (Threshold: 0.4) Nuclear Threshold Adj Stat 9 (Threshold: 0.2) Nuclear Threshold Adj Stat 9 (Threshold: 0.4) Nuclear Threshold Adj Stat 10 (Threshold: 0.2) Nuclear Threshold Adj Stat 10 (Threshold: 0.4) Nuclear Threshold Adj Stat 11 (Threshold: 0.2) Nuclear Threshold Adj Stat 11 (Threshold: 0.4) Nuclear Threshold Adj Stat 12 (Threshold: 0.2) Nuclear Threshold Adj Stat 12 (Threshold: 0.4) Nuclear Threshold Adj Stat 13 (Threshold: 0.2) Nuclear Threshold Adj Stat 13 (Threshold: 0.4) Nuclear Threshold Adj Stat 14 (Threshold: 0.2) Nuclear Threshold Adj Stat 14 (Threshold: 0.4) Nuclear Threshold Adj Stat 15 (Threshold: 0.2) Nuclear Threshold Adj Stat 15 (Threshold: 0.4) Nuclear Threshold Adj Stat 16 (Threshold: 0.2) Nuclear Threshold Adj Stat 16 (Threshold: 0.4) Nuclear Threshold Adj Stat 17 (Threshold: 0.2) Nuclear Threshold Adj Stat 17 (Threshold: 0.4) Nuclear Threshold Adj Stat 18 (Threshold: 0.2) Nuclear Threshold Adj Stat 18 (Threshold: 0.4) Nuclear Threshold Adj Stat 19 (Threshold: 0.2) Nuclear Threshold Adj Stat 19 (Threshold: 0.4) Nuclear Threshold Adj Stat 20 (Threshold: 0.2) Nuclear Threshold Adj Stat 20 (Threshold: 0.4) Nuclear Threshold Adj Stat 21 (Threshold: 0.2) Nuclear Threshold Adj Stat 21 (Threshold: 0.4) Nuclear Threshold Adj Stat 22 (Threshold: 0.2) Nuclear Threshold Adj Stat 22 (Threshold: 0.4) Nuclear Threshold Adj Stat 23 (Threshold: 0.2) Nuclear Threshold Adj Stat 23 (Threshold: 0.4) Nuclear Threshold Adj Stat 24 (Threshold: 0.2) Nuclear Threshold Adj Stat 24 (Threshold: 0.4) Nuclear Threshold Adj Stat 25 (Threshold: 0.2) Nuclear Threshold Adj Stat 25 (Threshold: 0.4) Nuclear Threshold Adj Stat 26 (Threshold: 0.2) Nuclear Threshold Adj Stat 26 (Threshold: 0.4) Nuclear Threshold Adj Stat 27 (Threshold: 0.2) Nuclear Threshold Adj Stat 27 (Threshold: 0.4) Nuclear Threshold Adj Stat 28 Nuclear Threshold Adj Stat 29 Nuclear Threshold Adj Stat 30 Nuclear Threshold Adj Stat 31 Nuclear Threshold Adj Stat 32 Nuclear Threshold Adj Stat 33 Nuclear Threshold Adj Stat 34 Nuclear Threshold Adj Stat 35 Nuclear Threshold Adj Stat 36 10% quantile of cytoplasm intensity (AU) 20% quantile of cytoplasm intensity (AU) 30% quantile of cytoplasm intensity (AU) 40% quantile of cytoplasm intensity (AU) 50% quantile of cytoplasm intensity (AU) 60% quantile of cytoplasm intensity (AU) 70% quantile of cytoplasm intensity (AU) 80% quantile of cytoplasm intensity (AU) 90% quantile of cytoplasm intensity (AU) Cytoplasmic Haralick ASM Cytoplasmic Haralick contrast Cytoplasmic Haralick entropy Cytoplasmic Haralick IDM Cytoplasmic Haralick moment 2 Cytoplasmic Haralick moment 3 Cytoplasmic Haralick moment 4 Cytoplasmic Haralick moment 5 Cytoplasmic radial moment (border) Cytoplasmic radial moment (center) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 28 Cytoplasmic Threshold Adj Stat 29 Cytoplasmic Threshold Adj Stat 30 Cytoplasmic Threshold Adj Stat 31 Cytoplasmic Threshold Adj Stat 32 Cytoplasmic Threshold Adj Stat 33 Cytoplasmic Threshold Adj Stat 34 Cytoplasmic Threshold Adj Stat 35 Cytoplasmic Threshold Adj Stat 36
MDA-MB-231
0
DRAQ5 1 TMRE 2 2 2 1 699 471 image if available 4304 9250 675.2 100.28 112.63 227.13 526 609 656 678 694 707 722 740 781 0.0782 723 1.058 105.04 31.11 1 0.0602 259 0.0017 29.52 6.816 0.2429 465980.0
327000000
234000000000
169000000000000
0.4313 0.2103 0.0000 0.0000 0.0000 0.0000 0.0008 0.0000 0.0028 0.0000 0.0204 0.0139 0.0353 0.0238 0.0311 0.0120 0.0487 0.0205 0.8609 0.9297 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0016 0.0000 0.0149 0.0139 0.0259 0.0238 0.0191 0.0120 0.0254 0.0205 0.9130 0.9297 0.0082 0.0000 0.0163 0.0000 0.0245 0.0000 0.0367 0.0000 0.0816 0.0000 0.0857 0.0000 0.0816 0.0000 0.1143 0.0000 0.5510 0.0000 0.0004 0.0015 0.0038 0.0128 0.0342 0.0556 0.0680 0.0992 0.7244 8 10 12 14 17 26 59 148 341 0.1976 21.25 3.579 0.6813 64269.9
61100000
74500000000
106000000000000
0.4869 0.1485 0.0430 0.0000 0.1471 0.0171 0.1991 0.0910 0.1222 0.1229 0.1357 0.1456 0.1154 0.1581 0.1086 0.1229 0.0633 0.1024 0.0656 0.2400 0.0000 0.0000 0.0008 0.0004 0.0013 0.0011 0.0109 0.0094 0.0419 0.0410 0.0747 0.0556 0.0516 0.0402 0.0763 0.0676 0.7425 0.7847 0.0000 0.0006 0.0010 0.0022 0.0031 0.0028 0.0175 0.0185 0.0577 0.0612 0.0911 0.1021 0.0695 0.0606 0.0901 0.0948 0.6699 0.6571 0.0000 0.0009 0.0032 0.0125 0.0529 0.0779 0.0682 0.0904 0.6939
BT-20 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 1211 757 image if available 6987 17413 330.1 42.49 131.75 174.14 277 295 309 320 331 341 352 366 384 0.0637 1110 0.875 72.84 16.16 1 0.0238 166 0.0022 16.55 6.447 0.2611 110777.0
37800000
13100000000
4580000000000
0.4400 0.2087 0.0000 0.0000 0.0005 0.0000 0.0010 0.0000 0.0062 0.0000 0.0213 0.0109 0.0321 0.0178 0.0485 0.0100 0.0745 0.0186 0.8160 0.9427 0.0000 0.0000 0.0002 0.0000 0.0003 0.0000 0.0027 0.0000 0.0128 0.0109 0.0169 0.0178 0.0198 0.0095 0.0305 0.0166 0.9167 0.9453 0.0122 0.0000 0.0389 1.0000 0.0681 0.0000 0.1387 0.0000 0.1363 0.0000 0.1533 0.0000 0.1314 0.0000 0.1265 0.0000 0.1946 0.0000 0.0017 0.0047 0.0111 0.0255 0.0505 0.0813 0.0921 0.1160 0.6171 11 14 16 20 45 85 148 242 391 0.0761 18.56 4.883 0.5466 47679.7
24000000
14300000000
9510000000000
0.5710 0.1004 0.0354 0.0022 0.1286 0.0170 0.1973 0.0815 0.1517 0.1130 0.1402 0.1735 0.1156 0.1590 0.0860 0.1101 0.0744 0.1093 0.0708 0.2342 0.0002 0.0003 0.0005 0.0013 0.0017 0.0015 0.0103 0.0083 0.0444 0.0392 0.0713 0.0616 0.0547 0.0447 0.0799 0.0686 0.7370 0.7746 0.0002 0.0007 0.0022 0.0016 0.0044 0.0034 0.0156 0.0158 0.0577 0.0657 0.0944 0.1062 0.0716 0.0725 0.0954 0.1069 0.6586 0.6274 0.0004 0.0009 0.0034 0.0130 0.0497 0.0852 0.0639 0.0887 0.6949
BT-20 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 705 883 image if available 6676 9244 499.2 67.15 152.67 174.40 413 445 465 483 499 516 533 554 585 0.0900 832 1.232 101.42 42.43 1 0.0400 267 0.0009 54.50 7.284 0.1641 253716.0
131000000
68900000000
36800000000000
0.4286 0.2213 0.0002 0.0000 0.0007 0.0000 0.0014 0.0000 0.0060 0.0000 0.0214 0.0109 0.0488 0.0210 0.0590 0.0100 0.0846 0.0168 0.7780 0.9412 0.0000 0.0000 0.0000 0.0000 0.0006 0.0000 0.0027 0.0000 0.0136 0.0106 0.0283 0.0205 0.0247 0.0094 0.0369 0.0151 0.8931 0.9443 0.0165 0.0000 0.0412 0.0000 0.0576 0.0000 0.0864 0.0000 0.1358 0.0000 0.1296 0.0000 0.1276 0.0000 0.1379 0.0000 0.2675 0.0000 0.0018 0.0036 0.0083 0.0283 0.0676 0.1221 0.1140 0.1355 0.5189 19 26 37 53 74 110 169 273 415 0.0207 24.07 5.517 0.4810 53719.9
26700000
15900000000
10600000000000
0.4686 0.1593 0.0797 0.0005 0.2210 0.0235 0.2295 0.1208 0.1292 0.1504 0.1075 0.1711 0.0821 0.1602 0.0483 0.1022 0.0628 0.1203 0.0399 0.1509 0.0003 0.0002 0.0015 0.0005 0.0038 0.0027 0.0145 0.0131 0.0737 0.0515 0.1088 0.1038 0.0748 0.0620 0.1129 0.1048 0.6098 0.6614 0.0000 0.0000 0.0008 0.0035 0.0050 0.0039 0.0218 0.0226 0.0916 0.0960 0.1439 0.1633 0.0871 0.0886 0.1226 0.1363 0.5273 0.4859 0.0003 0.0003 0.0037 0.0141 0.0844 0.1335 0.0820 0.1187 0.5629
MDA-MB-231 A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 828 731 image if available 4916 17078 344.5 49.98 70.06 109.17 278 302 316 330 344 358 374 391 410 0.0440 752 0.700 121.80 29.61 2 0.0728 358 0.0032 8.09 6.021 0.3596 121208.0
43500000
15900000000
5900000000000
0.4249 0.2173 0.0002 0.0000 0.0015 0.0000 0.0045 0.0000 0.0067 0.0000 0.0270 0.0128 0.0399 0.0214 0.0394 0.0128 0.0789 0.0218 0.8018 0.9312 0.0000 0.0000 0.0000 0.0000 0.0011 0.0000 0.0027 0.0000 0.0144 0.0128 0.0229 0.0214 0.0200 0.0128 0.0328 0.0185 0.9062 0.9345 0.0187 1.0000 0.0258 0.0000 0.0328 0.0000 0.0562 0.0000 0.1007 0.0000 0.1499 0.0000 0.1288 0.0000 0.1241 0.0000 0.3630 0.0000 0.0021 0.0041 0.0062 0.0144 0.0299 0.0533 0.0545 0.0685 0.7671 6 8 10 11 14 26 60 123 221 0.1196 5.30 3.437 0.5812 16825.5
6090000
2810000000
1590000000000
0.3847 0.2364 0.0327 0.0062 0.1401 0.0166 0.2424 0.0916 0.2139 0.1211 0.1718 0.1868 0.1149 0.2002 0.0516 0.1454 0.0263 0.1174 0.0063 0.1148 0.0000 0.0005 0.0006 0.0010 0.0023 0.0019 0.0083 0.0103 0.0391 0.0317 0.0712 0.0567 0.0463 0.0437 0.0805 0.0695 0.7518 0.7849 0.0000 0.0000 0.0009 0.0013 0.0021 0.0033 0.0145 0.0170 0.0532 0.0625 0.0907 0.0938 0.0628 0.0780 0.0937 0.1001 0.6822 0.6441 0.0004 0.0002 0.0032 0.0122 0.0464 0.0780 0.0622 0.0900 0.7075
MCF7 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 735 634 image if available 3383 13602 420.5 93.73 24.16 65.07 310 345 369 393 413 435 458 483 531 0.0471 641 0.708 187.75 42.58 1 0.1469 497 0.0008 81.64 7.362 0.1445 185607.0
86200000
42200000000
21900000000000
0.4414 0.2109 0.0000 0.0000 0.0000 0.0000 0.0048 0.0000 0.0190 0.0000 0.0557 0.0201 0.1348 0.0447 0.1232 0.0352 0.1517 0.0569 0.5108 0.8430 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0061 0.0000 0.0327 0.0138 0.0779 0.0312 0.0610 0.0204 0.0832 0.0309 0.7391 0.9038 0.0169 0.0000 0.0127 0.0252 0.0465 0.0377 0.0465 0.0755 0.1269 0.1447 0.1882 0.1698 0.0867 0.1195 0.1501 0.1069 0.3256 0.3208 0.0000 0.0050 0.0126 0.0320 0.0961 0.1420 0.1030 0.1470 0.4623 5 6 7 7 9 10 13 19 43 0.1856 1.96 2.069 0.6343 4817.1
2540000
1750000000
1330000000000
0.5397 0.1164 0.0580 0.0279 0.1116 0.0343 0.1949 0.0594 0.2024 0.1054 0.1741 0.1577 0.1310 0.1758 0.0759 0.1589 0.0387 0.1368 0.0134 0.1438 0.0052 0.0139 0.0041 0.0154 0.0067 0.0198 0.0191 0.0302 0.0479 0.0395 0.0621 0.0552 0.0592 0.0599 0.0943 0.0738 0.7012 0.6922 0.0010 0.0012 0.0035 0.0035 0.0045 0.0104 0.0205 0.0267 0.0730 0.0818 0.0985 0.1021 0.0725 0.0754 0.1151 0.1155 0.6113 0.5833 0.0026 0.0039 0.0039 0.0176 0.0511 0.0815 0.0686 0.1047 0.6662
SK-BR-3 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 400 407 image if available 6276 11399 375.7 86.02 140.41 164.45 245 323 357 378 396 413 428 444 463 0.0798 910 1.138 23.43 8.49 5 0.0099 62 0.0020 19.90 6.638 0.2782 148520.0
60600000
25300000000
10700000000000
0.3938 0.2401 0.0005 0.0000 0.0014 0.0000 0.0021 0.0000 0.0137 0.0000 0.0354 0.0108 0.0722 0.0252 0.0748 0.0104 0.1107 0.0183 0.6891 0.9352 0.0000 0.0000 0.0002 0.0000 0.0000 0.0000 0.0011 0.0000 0.0137 0.0108 0.0298 0.0252 0.0216 0.0104 0.0319 0.0169 0.9017 0.9367 0.0072 1.0000 0.0184 0.0000 0.0419 0.0000 0.0593 0.0000 0.0992 0.0000 0.1329 0.0000 0.1299 0.0000 0.1227 0.0000 0.3885 0.0000 0.0000 0.0010 0.0031 0.0067 0.0347 0.0601 0.0515 0.0772 0.7656 9 11 15 29 67 119 185 272 389 0.0593 7.25 4.451 0.5348 46754.1
20300000
10200000000
5650000000000
0.4511 0.1880 0.0237 0.0010 0.1225 0.0110 0.2381 0.0628 0.1729 0.1187 0.1275 0.1830 0.1265 0.1945 0.0810 0.1237 0.0632 0.1062 0.0445 0.1990 0.0000 0.0000 0.0008 0.0002 0.0017 0.0009 0.0089 0.0072 0.0450 0.0402 0.0820 0.0693 0.0542 0.0504 0.0858 0.0775 0.7214 0.7543 0.0003 0.0003 0.0030 0.0015 0.0041 0.0034 0.0160 0.0153 0.0574 0.0644 0.0907 0.1103 0.0655 0.0754 0.1045 0.1051 0.6586 0.6243 0.0002 0.0002 0.0019 0.0112 0.0594 0.0827 0.0622 0.0946 0.6875
BT-20 A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 270 229 image if available 650 7025 1251.1 283.87 11.58 3.56 859 957 1050 1150 1249 1356 1450 1553 1640 0.0757 532 1.003 35.47 12.37 1 0.1554 101 0.0018 76.01 6.355 0.1286 1650000.0
2260000000
3210000000000
4.71E+15
0.3546 0.2714 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0030 0.0000 0.0861 0.0357 0.1632 0.0683 0.0950 0.0233 0.1424 0.0714 0.5104 0.8012 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0020 0.0000 0.0405 0.0356 0.0729 0.0681 0.0304 0.0232 0.0547 0.0464 0.7996 0.8266 0.0000 1.0000 0.0000 0.0000 0.0000 0.0000 0.0127 0.0000 0.0828 0.0000 0.1083 0.0000 0.0573 0.0000 0.1083 0.0000 0.6306 0.0000 0.0000 0.0000 0.0000 0.0093 0.0556 0.0710 0.0525 0.0556 0.7562 7 9 10 11 11 12 13 14 16 0.0081 16.06 5.190 0.2777 146.9
2017.49
29808.4
471003
0.4942 0.1529 0.0108 0.0007 0.0396 0.0047 0.0930 0.0132 0.1508 0.0346 0.2124 0.0636 0.2362 0.1307 0.1635 0.2187 0.0792 0.3144 0.0144 0.2194 0.0046 0.0002 0.0197 0.0029 0.0427 0.0088 0.0534 0.0212 0.0813 0.0412 0.1242 0.0726 0.1697 0.1078 0.2247 0.2453 0.2797 0.5001 0.1226 0.2147 0.1534 0.1587 0.1534 0.1635 0.1480 0.1346 0.1180 0.1010 0.0987 0.0737 0.0887 0.0561 0.0717 0.0657 0.0455 0.0321 0.0277 0.0639 0.0858 0.1141 0.1354 0.1515 0.1521 0.1263 0.1433
MCF7 A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 516 891 image if available 618 739 106.8 15.78 5.93 2.23 82 92 99 105 109 114 118 121 125 0.3234 239 1.055 76.24 24.70 1 0.3026 187 0.0261 2.24 3.925 0.5232 11645.2
1290000
146000000
16700000000
0.3863 0.2434 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0199 0.0000 0.0358 0.0405 0.0875 0.0631 0.1093 0.0275 0.1590 0.0469 0.5885 0.8220 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0188 0.0000 0.0282 0.0405 0.0545 0.0631 0.0545 0.0275 0.0395 0.0469 0.8045 0.8220 0.1034 0.0000 0.2414 0.0000 0.2414 0.0000 0.2414 0.0000 0.1034 0.0000 0.0690 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0277 0.0360 0.0305 0.0637 0.0665 0.1108 0.6648 3 4 5 5 6 7 7 8 9 0.5158 0.30 0.942 0.8384 40.2
298.797
2399.87
20613.1
0.4399 0.1643 0.0054 0.0000 0.0863 0.0054 0.1563 0.0342 0.3100 0.1081 0.2022 0.1856 0.1725 0.2270 0.0566 0.2378 0.0108 0.1640 0.0000 0.0378 0.0000 0.0000 0.0186 0.0016 0.0557 0.0188 0.1002 0.0518 0.1670 0.1256 0.2041 0.1680 0.2059 0.2135 0.1837 0.2370 0.0649 0.1837 0.1845 0.4878 0.2917 0.2195 0.2440 0.2195 0.2024 0.0732 0.0476 0.0000 0.0298 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0213 0.0520 0.1348 0.1442 0.1891 0.1915 0.1277 0.1040 0.0355
MDA-MB-231 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 646 621 image if available 554 3317 275.3 19.34 19.44 28.31 251 261 267 272 276 281 286 292 299 0.1007 334 0.832 128.55 29.97 1 0.5108 283 0.0078 11.20 5.111 0.3312 76161.1
21200000
5910000000
1660000000000
0.3922 0.2458 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0453 0.0451 0.0652 0.0650 0.0380 0.0307 0.0580 0.0469 0.7935 0.8123 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0453 0.0451 0.0652 0.0650 0.0380 0.0307 0.0580 0.0469 0.7935 0.8123 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0067 0.0100 0.0300 0.0533 0.0900 0.1667 0.1333 0.1567 0.3533 7 8 9 9 11 12 15 22 33 0.0979 0.55 1.508 0.4506 1178.9
161332
29100000
5860000000
0.5686 0.1153 0.0480 0.0687 0.1051 0.0634 0.1471 0.0569 0.1952 0.0838 0.2462 0.0967 0.1532 0.1267 0.0811 0.1590 0.0210 0.2105 0.0030 0.1343 0.0121 0.0433 0.0141 0.0377 0.0121 0.0314 0.0313 0.0328 0.0555 0.0370 0.0757 0.0656 0.0858 0.0628 0.1171 0.1172 0.5964 0.5722 0.0091 0.0139 0.0106 0.0239 0.0152 0.0359 0.0410 0.0478 0.0699 0.0896 0.1307 0.1116 0.1185 0.1116 0.1413 0.1434 0.4635 0.4223 0.0059 0.0059 0.0118 0.0403 0.0557 0.0853 0.0936 0.1256 0.5758
SK-BR-3
0
DRAQ5 1 TMRE 2 2 2 1 149 113 image if available 323 5532 525.4 286.32 186.50 240.27 157 211 317 412 512 618 717 823 915 0.0660 365 0.959 111.89 35.36 1 0.8700 281 0.0034 148.51 5.705 0.0821 357777.0
277000000
230000000000
200000000000000
0.2729 0.3437 0.0000 0.0000 0.0000 0.0000 0.2615 0.0000 0.2462 0.0000 0.2308 0.1912 0.1385 0.2868 0.1077 0.1544 0.0154 0.2132 0.0000 0.1544 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0158 0.0000 0.0579 0.0746 0.1158 0.0921 0.0526 0.0395 0.0684 0.0833 0.6895 0.7105 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0320 0.0109 0.0960 0.1304 0.0960 0.1522 0.1200 0.0761 0.0960 0.1630 0.5600 0.4674 0.0000 0.0000 0.0000 0.0128 0.0833 0.1282 0.0449 0.0897 0.6410 7 10 12 16 37 159 263 383 524 0.0988 19.64 4.736 0.5044 92499.6
59900000
45800000000
39400000000000
0.5150 0.1603 0.0115 0.0013 0.0947 0.0117 0.1917 0.0352 0.1640 0.0992 0.1894 0.1815 0.1363 0.2128 0.0970 0.1214 0.0716 0.1488 0.0439 0.1880 0.0004 0.0000 0.0000 0.0008 0.0018 0.0008 0.0075 0.0062 0.0411 0.0369 0.0623 0.0542 0.0592 0.0468 0.0734 0.0735 0.7543 0.7809 0.0011 0.0012 0.0033 0.0036 0.0093 0.0042 0.0131 0.0203 0.0448 0.0449 0.0754 0.0862 0.0749 0.0778 0.0874 0.0898 0.6907 0.6721 0.0005 0.0005 0.0058 0.0155 0.0412 0.0722 0.0673 0.0785 0.7185
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 652 166 image if available 1359 6119 428.9 60.31 32.37 70.62 351 373 390 405 426 446 465 483 508 0.0709 434 0.794 97.08 19.70 1 0.1670 227 0.0023 22.07 6.272 0.2405 187585.0
83600000
38000000000
17500000000000
0.4204 0.2216 0.0009 0.0000 0.0000 0.0000 0.0026 0.0000 0.0061 0.0000 0.0462 0.0221 0.0688 0.0324 0.0592 0.0191 0.0897 0.0316 0.7265 0.8948 0.0000 0.0000 0.0000 0.0000 0.0024 0.0000 0.0016 0.0000 0.0293 0.0221 0.0443 0.0324 0.0332 0.0191 0.0546 0.0316 0.8347 0.8948 0.0259 0.0000 0.0000 0.0000 0.0000 0.0000 0.0776 0.0000 0.1638 0.0000 0.1983 0.0000 0.1207 0.0000 0.1379 0.0000 0.2759 0.0000 0.0000 0.0046 0.0077 0.0107 0.0475 0.0644 0.0706 0.0982 0.6963 6 8 9 10 11 13 15 23 79 0.3514 3.58 2.313 0.8106 6034.5
2460000
1350000000
863000000000
0.6003 0.1052 0.0807 0.0227 0.0807 0.0644 0.1211 0.0814 0.2870 0.1458 0.1435 0.1496 0.1480 0.1458 0.0762 0.1326 0.0583 0.1307 0.0045 0.1269 0.0088 0.0079 0.0044 0.0186 0.0071 0.0193 0.0274 0.0336 0.0398 0.0480 0.0548 0.0523 0.0610 0.0651 0.0839 0.0938 0.7129 0.6614 0.0000 0.0000 0.0044 0.0023 0.0055 0.0046 0.0143 0.0161 0.0539 0.0506 0.0462 0.0598 0.0616 0.0529 0.0935 0.0978 0.7206 0.7158 0.0020 0.0050 0.0090 0.0160 0.0548 0.0439 0.0499 0.1017 0.7178
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 957 935 image if available 646 1422 460.7 143.67 222.84 159.64 216 331 421 468 496 523 546 575 619 0.1871 266 0.763 79.76 18.68 1 0.3266 211 0.0022 28.41 6.205 0.2005 232878.0
124000000
68500000000
38700000000000
0.3597 0.2776 0.0000 0.0000 0.0000 0.0000 0.0032 0.0000 0.0162 0.0000 0.1262 0.0594 0.1489 0.0792 0.1392 0.0554 0.1845 0.1030 0.3819 0.7030 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0531 0.0495 0.0510 0.0531 0.0367 0.0348 0.0633 0.0531 0.7959 0.8095 0.0000 0.0244 0.0000 0.0000 0.0110 0.0000 0.0166 0.0488 0.1105 0.1707 0.1050 0.1951 0.0718 0.0976 0.1768 0.1951 0.5083 0.2683 0.0000 0.0000 0.0000 0.0101 0.0503 0.0528 0.0503 0.0729 0.7638 56 82 113 138 181 233 281 347 458 0.0035 32.63 6.085 0.3061 75125.3
32400000
16200000000
8980000000000
0.5133 0.1452 0.0079 0.0019 0.0791 0.0228 0.1897 0.0342 0.2095 0.0684 0.1976 0.1369 0.1581 0.1882 0.0672 0.1673 0.0751 0.1616 0.0158 0.2186 0.0000 0.0000 0.0014 0.0023 0.0014 0.0034 0.0195 0.0103 0.0627 0.0479 0.1393 0.1130 0.0669 0.0628 0.1170 0.0982 0.5919 0.6621 0.0000 0.0029 0.0000 0.0000 0.0086 0.0114 0.0409 0.0657 0.1054 0.1457 0.1699 0.1514 0.1032 0.1257 0.1527 0.1429 0.4194 0.3543 0.0000 0.0017 0.0017 0.0305 0.0746 0.1542 0.0847 0.1339 0.5186
MDA-MB-231 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 182 324 image if available 4862 8847 382.1 46.56 84.31 223.89 321 348 363 376 385 395 406 419 440 0.0849 751 0.869 141.40 42.45 2 0.0755 367 0.0020 27.89 6.580 0.2423 148135.0
58200000
23200000000
9310000000000
0.4327 0.2087 0.0002 0.0000 0.0002 0.0000 0.0009 0.0000 0.0044 0.0000 0.0215 0.0134 0.0430 0.0245 0.0423 0.0117 0.0642 0.0210 0.8233 0.9294 0.0002 0.0000 0.0002 0.0000 0.0000 0.0000 0.0018 0.0000 0.0153 0.0134 0.0306 0.0245 0.0237 0.0117 0.0317 0.0210 0.8966 0.9294 0.0214 0.0000 0.0856 0.0000 0.1016 0.0000 0.1283 0.0000 0.1176 0.0000 0.1444 0.0000 0.1016 0.0000 0.1123 0.0000 0.1872 0.0000 0.0019 0.0049 0.0106 0.0314 0.0538 0.0947 0.0981 0.1163 0.5883 8 9 11 12 13 15 20 43 199 0.1434 6.44 2.531 0.5616 57228.9
60400000
73600000000
96900000000000
0.7057 0.0462 0.0466 0.0000 0.0975 0.0157 0.2458 0.0747 0.1144 0.1041 0.1653 0.1434 0.1483 0.1945 0.1102 0.1611 0.0466 0.1336 0.0254 0.1729 0.0007 0.0000 0.0000 0.0012 0.0014 0.0048 0.0144 0.0133 0.0390 0.0387 0.0787 0.0678 0.0568 0.0599 0.1026 0.0998 0.7066 0.7145 0.0000 0.0000 0.0000 0.0035 0.0016 0.0009 0.0122 0.0192 0.0636 0.0603 0.0865 0.0857 0.0530 0.0594 0.1117 0.0970 0.6713 0.6740 0.0000 0.0008 0.0023 0.0129 0.0530 0.0802 0.0560 0.1104 0.6846
MDA-MB-231
0
DRAQ5 1 TMRE 2 2 2 1 526 612 image if available 4592 11096 714.2 99.82 91.74 166.81 589 634 669 693 712 732 756 790 865 0.0617 685 1.192 82.49 32.31 1 0.0464 213 0.0012 39.16 7.036 0.2240 520098.0
386000000
291000000000
223000000000000
0.3926 0.2577 0.0013 0.0000 0.0016 0.0000 0.0024 0.0000 0.0078 0.0000 0.0202 0.0126 0.0427 0.0244 0.0333 0.0109 0.0462 0.0196 0.8444 0.9324 0.0000 0.0000 0.0000 0.0000 0.0002 0.0000 0.0021 0.0000 0.0120 0.0126 0.0271 0.0244 0.0165 0.0109 0.0268 0.0196 0.9153 0.9324 0.0000 0.0000 0.0000 0.0000 0.0133 0.0000 0.0285 0.0000 0.0645 0.0000 0.1082 0.0000 0.1176 0.0000 0.1442 0.0000 0.5237 0.0000 0.0022 0.0027 0.0111 0.0200 0.0408 0.0616 0.0585 0.0789 0.7242 7 9 10 13 19 35 59 122 282 0.1396 15.62 3.866 0.6295 36238.5
22600000
17000000000
14400000000000
0.4303 0.1803 0.0541 0.0062 0.1723 0.0346 0.2804 0.0892 0.1486 0.1277 0.1216 0.1600 0.0912 0.1738 0.0456 0.1138 0.0372 0.1200 0.0490 0.1746 0.0007 0.0006 0.0014 0.0026 0.0061 0.0038 0.0208 0.0191 0.0546 0.0430 0.0869 0.0774 0.0440 0.0543 0.0617 0.0676 0.7238 0.7317 0.0009 0.0009 0.0021 0.0023 0.0081 0.0069 0.0214 0.0236 0.0585 0.0573 0.0880 0.0906 0.0440 0.0495 0.0679 0.0703 0.7091 0.6986 0.0008 0.0015 0.0073 0.0191 0.0546 0.0863 0.0454 0.0569 0.7281