High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)

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Cell SM Name Small Mol Concentration Small Mol Conc Unit Other Reagent 1 Name Other Reagent 1 Detection Channel Other Reagent 2 Name Other Reagent 2 Detection Channel Row Column Field X-coordinate Y-coordinate Image Nuclear area (pixels) Cytoplasm area (pixels) Nuclear intensity (AU) Std Dev of nuclear intensity (AU) Cytoplasm intensity (AU) Std Dev of cytoplasm intensity (AU) 10% quantile of nuclear intensity (AU) 20% quantile of nuclear intensity (AU) 30% quantile of nuclear intensity (AU) 40% quantile of nuclear intensity (AU) 50% quantile of nuclear intensity (AU) 60% quantile of nuclear intensity (AU) 70% quantile of nuclear intensity (AU) 80% quantile of nuclear intensity (AU) 90% quantile of nuclear intensity (AU) Ratio of cytoplasm perimeter to area Cytoplasm perimeter (pixels) Nuclear roundness Nuclear length (pixels) Nuclear halfwidth (pixels) Number of nuclei Ratio of nuclear perimeter to area Nuclear perimeter (pixels) Nuclear Haralick ASM Nuclear Haralick contrast Nuclear Haralick entropy Nuclear Haralick IDM Nuclear Haralick moment 2 Nuclear Haralick moment 3 Nuclear Haralick moment 4 Nuclear Haralick moment 5 Nuclear radial moment (border) Nuclear radial moment (center) Nuclear Threshold Adj Stat 1 (Threshold: 0.2) Nuclear Threshold Adj Stat 1 (Threshold: 0.4) Nuclear Threshold Adj Stat 2 (Threshold: 0.2) Nuclear Threshold Adj Stat 2 (Threshold: 0.4) Nuclear Threshold Adj Stat 3 (Threshold: 0.2) Nuclear Threshold Adj Stat 3 (Threshold: 0.4) Nuclear Threshold Adj Stat 4 (Threshold: 0.2) Nuclear Threshold Adj Stat 4 (Threshold: 0.4) Nuclear Threshold Adj Stat 5 (Threshold: 0.2) Nuclear Threshold Adj Stat 5 (Threshold: 0.4) Nuclear Threshold Adj Stat 6 (Threshold: 0.2) Nuclear Threshold Adj Stat 6 (Threshold: 0.4) Nuclear Threshold Adj Stat 7 (Threshold: 0.2) Nuclear Threshold Adj Stat 7 (Threshold: 0.4) Nuclear Threshold Adj Stat 8 (Threshold: 0.2) Nuclear Threshold Adj Stat 8 (Threshold: 0.4) Nuclear Threshold Adj Stat 9 (Threshold: 0.2) Nuclear Threshold Adj Stat 9 (Threshold: 0.4) Nuclear Threshold Adj Stat 10 (Threshold: 0.2) Nuclear Threshold Adj Stat 10 (Threshold: 0.4) Nuclear Threshold Adj Stat 11 (Threshold: 0.2) Nuclear Threshold Adj Stat 11 (Threshold: 0.4) Nuclear Threshold Adj Stat 12 (Threshold: 0.2) Nuclear Threshold Adj Stat 12 (Threshold: 0.4) Nuclear Threshold Adj Stat 13 (Threshold: 0.2) Nuclear Threshold Adj Stat 13 (Threshold: 0.4) Nuclear Threshold Adj Stat 14 (Threshold: 0.2) Nuclear Threshold Adj Stat 14 (Threshold: 0.4) Nuclear Threshold Adj Stat 15 (Threshold: 0.2) Nuclear Threshold Adj Stat 15 (Threshold: 0.4) Nuclear Threshold Adj Stat 16 (Threshold: 0.2) Nuclear Threshold Adj Stat 16 (Threshold: 0.4) Nuclear Threshold Adj Stat 17 (Threshold: 0.2) Nuclear Threshold Adj Stat 17 (Threshold: 0.4) Nuclear Threshold Adj Stat 18 (Threshold: 0.2) Nuclear Threshold Adj Stat 18 (Threshold: 0.4) Nuclear Threshold Adj Stat 19 (Threshold: 0.2) Nuclear Threshold Adj Stat 19 (Threshold: 0.4) Nuclear Threshold Adj Stat 20 (Threshold: 0.2) Nuclear Threshold Adj Stat 20 (Threshold: 0.4) Nuclear Threshold Adj Stat 21 (Threshold: 0.2) Nuclear Threshold Adj Stat 21 (Threshold: 0.4) Nuclear Threshold Adj Stat 22 (Threshold: 0.2) Nuclear Threshold Adj Stat 22 (Threshold: 0.4) Nuclear Threshold Adj Stat 23 (Threshold: 0.2) Nuclear Threshold Adj Stat 23 (Threshold: 0.4) Nuclear Threshold Adj Stat 24 (Threshold: 0.2) Nuclear Threshold Adj Stat 24 (Threshold: 0.4) Nuclear Threshold Adj Stat 25 (Threshold: 0.2) Nuclear Threshold Adj Stat 25 (Threshold: 0.4) Nuclear Threshold Adj Stat 26 (Threshold: 0.2) Nuclear Threshold Adj Stat 26 (Threshold: 0.4) Nuclear Threshold Adj Stat 27 (Threshold: 0.2) Nuclear Threshold Adj Stat 27 (Threshold: 0.4) Nuclear Threshold Adj Stat 28 Nuclear Threshold Adj Stat 29 Nuclear Threshold Adj Stat 30 Nuclear Threshold Adj Stat 31 Nuclear Threshold Adj Stat 32 Nuclear Threshold Adj Stat 33 Nuclear Threshold Adj Stat 34 Nuclear Threshold Adj Stat 35 Nuclear Threshold Adj Stat 36 10% quantile of cytoplasm intensity (AU) 20% quantile of cytoplasm intensity (AU) 30% quantile of cytoplasm intensity (AU) 40% quantile of cytoplasm intensity (AU) 50% quantile of cytoplasm intensity (AU) 60% quantile of cytoplasm intensity (AU) 70% quantile of cytoplasm intensity (AU) 80% quantile of cytoplasm intensity (AU) 90% quantile of cytoplasm intensity (AU) Cytoplasmic Haralick ASM Cytoplasmic Haralick contrast Cytoplasmic Haralick entropy Cytoplasmic Haralick IDM Cytoplasmic Haralick moment 2 Cytoplasmic Haralick moment 3 Cytoplasmic Haralick moment 4 Cytoplasmic Haralick moment 5 Cytoplasmic radial moment (border) Cytoplasmic radial moment (center) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 28 Cytoplasmic Threshold Adj Stat 29 Cytoplasmic Threshold Adj Stat 30 Cytoplasmic Threshold Adj Stat 31 Cytoplasmic Threshold Adj Stat 32 Cytoplasmic Threshold Adj Stat 33 Cytoplasmic Threshold Adj Stat 34 Cytoplasmic Threshold Adj Stat 35 Cytoplasmic Threshold Adj Stat 36
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 1219 611 image if available 6727 10795 500.4 87.18 61.57 164.61 389 436 464 484 500 519 539 564 613 0.0766 827 0.887 151.21 35.90 4 0.0523 352 0.0010 40.11 7.197 0.1973 258004.0
137000000
74100000000
41200000000000
0.4599 0.1961 0.0006 0.0000 0.0008 0.0000 0.0006 0.0000 0.0061 0.0005 0.0334 0.0138 0.0743 0.0305 0.0688 0.0200 0.0981 0.0361 0.7174 0.8992 0.0003 0.0000 0.0003 0.0000 0.0002 0.0000 0.0020 0.0002 0.0203 0.0122 0.0431 0.0268 0.0321 0.0141 0.0475 0.0242 0.8540 0.9226 0.0036 0.0385 0.0109 0.0641 0.0243 0.0256 0.0510 0.1282 0.0875 0.2179 0.1179 0.2179 0.0899 0.1026 0.1118 0.1026 0.5030 0.1026 0.0015 0.0026 0.0100 0.0280 0.0665 0.1130 0.0971 0.1266 0.5546 5 5 7 8 9 10 12 20 145 0.3474 14.59 2.480 0.7590 30885.0
22100000
18100000000
16500000000000
0.6221 0.0747 0.0404 0.0026 0.1515 0.0289 0.2172 0.0525 0.2071 0.1732 0.1515 0.2310 0.1414 0.2047 0.0505 0.1260 0.0303 0.0866 0.0101 0.0945 0.0000 0.0006 0.0006 0.0030 0.0032 0.0024 0.0121 0.0119 0.0401 0.0351 0.0650 0.0660 0.0510 0.0463 0.0643 0.0564 0.7637 0.7784 0.0000 0.0000 0.0015 0.0015 0.0015 0.0038 0.0175 0.0215 0.0445 0.0445 0.0729 0.0722 0.0590 0.0507 0.0649 0.0753 0.7383 0.7304 0.0000 0.0014 0.0020 0.0143 0.0442 0.0626 0.0558 0.0721 0.7476
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 170 550 image if available 8750 8424 502.4 87.96 41.36 73.23 382 421 449 477 504 533 561 587 616 0.0991 835 0.776 84.48 24.52 5 0.0277 242 0.0010 31.96 7.187 0.2170 260103.0
138000000
75400000000
41900000000000
0.4172 0.2234 0.0005 0.0000 0.0021 0.0000 0.0032 0.0000 0.0111 0.0005 0.0476 0.0114 0.0760 0.0187 0.0904 0.0131 0.1317 0.0244 0.6373 0.9319 0.0003 0.0000 0.0001 0.0000 0.0008 0.0000 0.0043 0.0005 0.0214 0.0113 0.0331 0.0183 0.0365 0.0119 0.0525 0.0214 0.8509 0.9367 0.0126 0.1000 0.0126 0.2000 0.0356 0.5000 0.0617 0.2000 0.1146 0.0000 0.1486 0.0000 0.1328 0.0000 0.1518 0.0000 0.3296 0.0000 0.0014 0.0023 0.0063 0.0160 0.0405 0.0657 0.0673 0.0822 0.7184 8 10 12 13 16 20 28 44 98 0.1584 2.61 3.052 0.7597 7073.0
2420000
1080000000
547000000000
0.6438 0.0750 0.0266 0.0119 0.0620 0.0252 0.1004 0.0365 0.1492 0.0697 0.1905 0.1048 0.1418 0.1287 0.1536 0.1301 0.0960 0.1858 0.0798 0.3072 0.0055 0.0063 0.0104 0.0116 0.0127 0.0137 0.0209 0.0256 0.0563 0.0460 0.0700 0.0674 0.0691 0.0593 0.1004 0.1092 0.6547 0.6608 0.0000 0.0045 0.0052 0.0037 0.0085 0.0082 0.0184 0.0231 0.0636 0.0723 0.0932 0.0835 0.0636 0.0776 0.1122 0.1148 0.6352 0.6122 0.0011 0.0038 0.0098 0.0235 0.0573 0.0742 0.0770 0.1070 0.6463
MDA-MB-231 A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 419 941 image if available 1482 6727 623.1 187.74 39.98 47.19 345 427 507 585 646 704 748 798 856 0.0824 554 1.155 59.68 15.62 2 0.0857 127 0.0011 48.66 6.906 0.1667 423486.0
307000000
233000000000
182000000000000
0.3666 0.2504 0.0000 0.0000 0.0000 0.0000 0.0067 0.0009 0.0083 0.0077 0.0998 0.0404 0.1647 0.0482 0.1148 0.0490 0.1664 0.0782 0.4393 0.7756 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0019 0.0023 0.0344 0.0313 0.0411 0.0313 0.0306 0.0305 0.0525 0.0477 0.8395 0.8569 0.0022 0.0172 0.0022 0.0000 0.0067 0.0517 0.0247 0.0345 0.0605 0.0862 0.0919 0.0862 0.0740 0.0948 0.0830 0.1207 0.6547 0.5086 0.0000 0.0000 0.0000 0.0100 0.0375 0.0463 0.0438 0.0688 0.7938 9 12 15 18 23 29 37 55 98 0.0440 4.34 4.026 0.6372 3825.0
658362
157000000
45400000000
0.4438 0.2100 0.0158 0.0125 0.0565 0.0171 0.0949 0.0260 0.1616 0.0473 0.2011 0.0816 0.1638 0.1247 0.1333 0.1418 0.1209 0.1829 0.0520 0.3662 0.0041 0.0068 0.0127 0.0101 0.0151 0.0120 0.0262 0.0184 0.0454 0.0369 0.0654 0.0513 0.0634 0.0553 0.1079 0.0980 0.6599 0.7113 0.0019 0.0030 0.0038 0.0030 0.0122 0.0098 0.0275 0.0255 0.0487 0.0579 0.0890 0.0826 0.0602 0.0594 0.0922 0.0962 0.6643 0.6627 0.0053 0.0075 0.0150 0.0241 0.0470 0.0780 0.0625 0.0941 0.6665
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 284 471 image if available 1555 4253 401.1 47.90 19.31 18.63 332 364 381 394 406 416 429 441 459 0.0997 424 1.147 61.20 22.02 1 0.1016 158 0.0027 20.18 6.139 0.2451 163138.0
67200000
28000000000
11800000000000
0.4443 0.1979 0.0000 0.0000 0.0000 0.0000 0.0007 0.0000 0.0028 0.0006 0.0285 0.0239 0.0463 0.0303 0.0484 0.0232 0.0855 0.0342 0.7877 0.8877 0.0000 0.0000 0.0000 0.0000 0.0007 0.0000 0.0028 0.0006 0.0241 0.0239 0.0345 0.0303 0.0241 0.0232 0.0427 0.0342 0.8711 0.8877 0.0426 0.0000 0.1064 0.0000 0.1064 0.0000 0.1277 0.0000 0.2340 0.0000 0.1702 0.0000 0.0638 0.0000 0.1064 0.0000 0.0426 0.0000 0.0000 0.0060 0.0072 0.0358 0.0656 0.1144 0.1085 0.1323 0.5304 8 10 11 13 14 16 18 23 33 0.2369 0.56 2.092 0.8275 719.8
57928.3
7540000
1230000000
0.5877 0.1129 0.1023 0.0171 0.1338 0.0274 0.1250 0.0499 0.1439 0.0846 0.1452 0.1170 0.1351 0.1471 0.1225 0.1498 0.0682 0.1619 0.0240 0.2452 0.0447 0.0107 0.0494 0.0169 0.0353 0.0331 0.0358 0.0562 0.0529 0.0841 0.0764 0.1041 0.0781 0.1013 0.1193 0.1162 0.5082 0.4774 0.0132 0.0162 0.0154 0.0310 0.0209 0.0398 0.0473 0.0516 0.0780 0.0634 0.0978 0.1165 0.1022 0.0870 0.1516 0.1608 0.4736 0.4336 0.0277 0.0317 0.0222 0.0301 0.0586 0.0705 0.0777 0.1474 0.5341
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 1140 503 image if available 4025 13483 436.8 85.79 132.10 242.48 338 368 391 415 440 463 488 513 540 0.0518 698 1.105 49.03 18.38 2 0.0330 133 0.0012 33.18 6.972 0.2087 198109.0
92600000
44400000000
21800000000000
0.4526 0.1884 0.0007 0.0000 0.0014 0.0000 0.0035 0.0000 0.0139 0.0010 0.0522 0.0198 0.1099 0.0311 0.0967 0.0257 0.1398 0.0363 0.5819 0.8861 0.0006 0.0000 0.0000 0.0000 0.0003 0.0000 0.0037 0.0005 0.0267 0.0189 0.0517 0.0288 0.0402 0.0186 0.0577 0.0283 0.8190 0.9049 0.0050 0.0000 0.0033 0.0606 0.0429 0.1515 0.0759 0.2121 0.1188 0.1212 0.1914 0.2424 0.1452 0.1515 0.1551 0.0303 0.2624 0.0303 0.0005 0.0024 0.0058 0.0169 0.0551 0.0851 0.0807 0.1054 0.6481 6 7 9 10 14 25 74 196 483 0.1545 27.57 4.157 0.6237 76242.5
60100000
54300000000
53300000000000
0.5764 0.1021 0.0301 0.0017 0.1284 0.0108 0.1997 0.0687 0.1458 0.1026 0.1838 0.1745 0.1331 0.1977 0.0666 0.1266 0.0602 0.1290 0.0523 0.1886 0.0003 0.0000 0.0005 0.0008 0.0025 0.0013 0.0066 0.0078 0.0442 0.0373 0.0700 0.0607 0.0437 0.0396 0.0626 0.0595 0.7696 0.7931 0.0000 0.0014 0.0013 0.0014 0.0027 0.0036 0.0166 0.0159 0.0525 0.0587 0.0807 0.0844 0.0558 0.0543 0.0751 0.0736 0.7153 0.7065 0.0003 0.0012 0.0033 0.0100 0.0504 0.0697 0.0573 0.0733 0.7346
MCF7
0
DRAQ5 1 TMRE 2 2 2 1 477 426 image if available 5377 19317 581.1 160.29 136.17 209.41 425 459 484 509 534 566 617 705 822 0.0467 902 1.031 97.32 27.29 2 0.0433 233 0.0008 63.73 7.412 0.1708 363397.0
246000000
181000000000
144000000000000
0.3855 0.2619 0.0003 0.0000 0.0003 0.0000 0.0029 0.0002 0.0165 0.0025 0.0836 0.0253 0.1454 0.0498 0.1535 0.0451 0.1707 0.0641 0.4266 0.8129 0.0000 0.0000 0.0002 0.0000 0.0007 0.0000 0.0048 0.0002 0.0452 0.0152 0.0767 0.0238 0.0829 0.0208 0.1093 0.0315 0.6802 0.9084 0.0018 0.0000 0.0018 0.0068 0.0063 0.0068 0.0288 0.0342 0.0728 0.1182 0.1150 0.1541 0.0584 0.0908 0.0988 0.1404 0.6164 0.4486 0.0015 0.0026 0.0128 0.0271 0.0767 0.1048 0.0772 0.0905 0.6069 6 8 9 12 19 59 148 254 436 0.1238 34.07 4.718 0.5673 62391.7
40700000
33200000000
32300000000000
0.4255 0.1972 0.0345 0.0023 0.1373 0.0110 0.2596 0.0799 0.2092 0.1106 0.1690 0.2037 0.1018 0.1992 0.0495 0.1293 0.0271 0.1275 0.0121 0.1366 0.0003 0.0000 0.0005 0.0001 0.0009 0.0000 0.0059 0.0038 0.0367 0.0320 0.0589 0.0488 0.0443 0.0411 0.0677 0.0553 0.7847 0.8190 0.0002 0.0002 0.0002 0.0014 0.0007 0.0008 0.0100 0.0122 0.0407 0.0531 0.0851 0.0882 0.0557 0.0635 0.0838 0.0904 0.7235 0.6902 0.0000 0.0000 0.0005 0.0065 0.0403 0.0668 0.0522 0.0737 0.7600
BT-20 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 739 828 image if available 3336 10996 733.4 131.67 162.29 302.51 560 619 661 696 729 766 805 848 907 0.0851 936 1.020 70.01 22.36 1 0.0525 175 0.0011 45.93 7.024 0.1864 555153.0
433000000
346000000000
284000000000000
0.4491 0.1924 0.0000 0.0000 0.0004 0.0000 0.0008 0.0000 0.0070 0.0003 0.0488 0.0168 0.1141 0.0324 0.0930 0.0251 0.1439 0.0321 0.5920 0.8934 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0024 0.0003 0.0255 0.0157 0.0541 0.0275 0.0375 0.0151 0.0620 0.0236 0.8185 0.9178 0.0041 0.0000 0.0000 0.0541 0.0269 0.1081 0.0579 0.2432 0.1467 0.1892 0.2004 0.2973 0.1240 0.0270 0.1508 0.0541 0.2893 0.0270 0.0000 0.0025 0.0105 0.0215 0.0732 0.0942 0.0905 0.1046 0.6031 8 10 11 12 14 20 71 262 593 0.2612 53.14 3.819 0.6522 117840.0
116000000
132000000000
164000000000000
0.5865 0.0859 0.1144 0.0083 0.2779 0.0904 0.2861 0.2629 0.1417 0.1599 0.1063 0.1460 0.0436 0.1252 0.0272 0.0918 0.0027 0.0668 0.0000 0.0487 0.0000 0.0000 0.0007 0.0003 0.0007 0.0007 0.0093 0.0101 0.0593 0.0520 0.1052 0.1002 0.0576 0.0598 0.1014 0.0881 0.6657 0.6888 0.0000 0.0008 0.0008 0.0013 0.0024 0.0051 0.0154 0.0166 0.0675 0.0696 0.1110 0.1099 0.0667 0.0743 0.1082 0.1002 0.6280 0.6222 0.0000 0.0007 0.0011 0.0136 0.0618 0.1045 0.0674 0.0986 0.6522
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 1013 682 image if available 13732 29163 489.2 88.51 64.45 140.69 369 416 448 471 492 513 535 561 598 0.0441 1286 0.817 91.92 19.24 13 0.0163 224 0.0009 42.91 7.350 0.2018 247158.0
129000000
68600000000
37500000000000
0.4764 0.1806 0.0003 0.0000 0.0008 0.0000 0.0010 0.0002 0.0078 0.0008 0.0407 0.0122 0.0790 0.0262 0.0719 0.0181 0.1073 0.0285 0.6912 0.9139 0.0000 0.0000 0.0002 0.0000 0.0001 0.0000 0.0022 0.0004 0.0199 0.0104 0.0412 0.0212 0.0321 0.0132 0.0499 0.0202 0.8544 0.9345 0.0040 0.0187 0.0103 0.0327 0.0343 0.0467 0.0623 0.0561 0.1189 0.1402 0.1320 0.2150 0.0971 0.1122 0.1223 0.1636 0.4189 0.2150 0.0010 0.0013 0.0046 0.0192 0.0608 0.1022 0.0895 0.1194 0.6020 6 7 9 10 11 13 21 61 192 0.2959 12.61 3.087 0.7489 23946.5
14200000
10300000000
8680000000000
0.5403 0.1285 0.0409 0.0032 0.1110 0.0290 0.1519 0.0767 0.1548 0.0965 0.1500 0.1282 0.1519 0.1650 0.1042 0.1195 0.0828 0.1232 0.0526 0.2587 0.0003 0.0007 0.0006 0.0010 0.0021 0.0026 0.0106 0.0112 0.0421 0.0350 0.0683 0.0631 0.0405 0.0400 0.0644 0.0618 0.7712 0.7846 0.0002 0.0000 0.0013 0.0008 0.0025 0.0025 0.0115 0.0135 0.0507 0.0532 0.0788 0.0824 0.0465 0.0475 0.0710 0.0731 0.7375 0.7270 0.0007 0.0010 0.0017 0.0150 0.0416 0.0733 0.0472 0.0663 0.7529
MDA-MB-231 A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 350 768 image if available 2148 7377 649.8 190.42 59.61 108.11 361 467 544 624 689 729 767 811 863 0.0729 538 0.439 61.06 9.22 3 0.0791 170 0.0009 72.75 7.161 0.1651 458473.0
344000000
270000000000
221000000000000
0.4160 0.2058 0.0000 0.0000 0.0000 0.0000 0.0050 0.0006 0.0291 0.0023 0.0824 0.0283 0.1568 0.0702 0.1075 0.0385 0.1397 0.0645 0.4794 0.7957 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0045 0.0016 0.0293 0.0240 0.0560 0.0464 0.0350 0.0235 0.0592 0.0427 0.8160 0.8617 0.0000 0.0094 0.0000 0.0283 0.0035 0.0189 0.0260 0.0566 0.0781 0.1415 0.1163 0.2264 0.0885 0.0472 0.1250 0.1038 0.5625 0.3679 0.0000 0.0000 0.0000 0.0091 0.0432 0.0639 0.0490 0.0763 0.7585 7 9 11 13 16 21 32 64 203 0.0746 10.49 3.983 0.6307 15239.4
6560000
3660000000
2420000000000
0.2920 0.3302 0.0000 0.0050 0.0655 0.0113 0.2143 0.0239 0.2292 0.0642 0.2054 0.1597 0.1429 0.2013 0.0774 0.1660 0.0506 0.1698 0.0149 0.1987 0.0000 0.0019 0.0017 0.0043 0.0040 0.0038 0.0115 0.0125 0.0340 0.0355 0.0530 0.0485 0.0363 0.0384 0.0594 0.0677 0.8000 0.7872 0.0000 0.0000 0.0000 0.0000 0.0043 0.0031 0.0129 0.0109 0.0372 0.0427 0.0558 0.0637 0.0393 0.0365 0.0629 0.0637 0.7877 0.7793 0.0000 0.0000 0.0007 0.0170 0.0352 0.0483 0.0463 0.0614 0.7911
MDA-MB-231
0
DRAQ5 1 TMRE 2 2 2 1 287 208 image if available 5091 12471 474.1 73.02 68.38 135.66 363 414 452 475 490 504 518 533 553 0.0763 952 1.174 64.62 19.85 1 0.0297 151 0.0020 19.65 6.571 0.2736 230087.0
114000000
57200000000
29100000000000
0.4330 0.2034 0.0002 0.0000 0.0000 0.0000 0.0019 0.0000 0.0074 0.0012 0.0203 0.0121 0.0432 0.0234 0.0404 0.0127 0.0650 0.0183 0.8215 0.9322 0.0000 0.0000 0.0000 0.0000 0.0002 0.0000 0.0032 0.0012 0.0131 0.0121 0.0257 0.0234 0.0181 0.0127 0.0235 0.0183 0.9163 0.9322 0.0328 0.0000 0.0615 0.0000 0.1025 0.0000 0.1311 0.0000 0.1352 0.0000 0.1352 0.0000 0.1230 0.0000 0.0820 0.0000 0.1967 0.0000 0.0000 0.0026 0.0065 0.0091 0.0308 0.0587 0.0532 0.0834 0.7557 6 8 9 11 15 21 36 71 216 0.1260 12.46 3.408 0.6217 23078.9
13100000
9690000000
8870000000000
0.4949 0.1599 0.0417 0.0057 0.1106 0.0278 0.1571 0.0785 0.1234 0.0849 0.1619 0.1091 0.1250 0.1320 0.1106 0.1084 0.1090 0.1434 0.0609 0.3103 0.0024 0.0014 0.0044 0.0028 0.0051 0.0068 0.0139 0.0160 0.0493 0.0376 0.0748 0.0673 0.0479 0.0450 0.0816 0.0730 0.7206 0.7501 0.0000 0.0014 0.0017 0.0009 0.0043 0.0047 0.0181 0.0161 0.0513 0.0584 0.0945 0.1011 0.0513 0.0570 0.0815 0.0783 0.6972 0.6820 0.0008 0.0012 0.0043 0.0152 0.0519 0.0831 0.0542 0.0807 0.7087
MDA-MB-231 A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 354 420 image if available 1298 8819 703.5 137.06 40.06 42.60 498 566 622 685 723 762 800 837 868 0.0693 611 0.939 34.21 8.06 4 0.0624 81 0.0013 60.83 6.801 0.1510 513652.0
387000000
299000000000
236000000000000
0.4003 0.2202 0.0000 0.0000 0.0012 0.0000 0.0012 0.0000 0.0085 0.0008 0.0932 0.0281 0.1538 0.0532 0.1356 0.0258 0.1586 0.0446 0.4479 0.8475 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0019 0.0008 0.0458 0.0281 0.0715 0.0532 0.0372 0.0258 0.0696 0.0446 0.7741 0.8475 0.0045 0.0000 0.0135 0.0000 0.0269 0.0000 0.0628 0.0000 0.1704 0.0000 0.1883 0.0000 0.1390 0.0000 0.1749 0.0000 0.2197 0.0000 0.0000 0.0000 0.0014 0.0124 0.0634 0.1007 0.0703 0.1131 0.6386 12 14 16 19 24 30 39 56 96 0.0579 5.04 3.928 0.6486 3419.8
510086
108000000
28300000000
0.4195 0.2154 0.0197 0.0099 0.0599 0.0129 0.1125 0.0254 0.1289 0.0420 0.1724 0.0884 0.1634 0.1256 0.1330 0.1219 0.1371 0.1819 0.0731 0.3921 0.0057 0.0056 0.0106 0.0065 0.0157 0.0127 0.0205 0.0169 0.0410 0.0340 0.0651 0.0498 0.0576 0.0514 0.0923 0.0910 0.6916 0.7322 0.0014 0.0017 0.0062 0.0028 0.0105 0.0062 0.0253 0.0258 0.0581 0.0624 0.0781 0.0983 0.0696 0.0736 0.0948 0.0893 0.6560 0.6399 0.0019 0.0054 0.0101 0.0260 0.0490 0.0707 0.0634 0.1014 0.6720
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 259 595 image if available 3281 8845 537.2 98.78 47.70 69.98 406 455 487 513 535 555 578 608 681 0.0684 605 1.005 109.84 37.48 2 0.0884 290 0.0012 24.77 6.942 0.2330 298323.0
171000000
101000000000
61500000000000
0.4559 0.1915 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0076 0.0006 0.0295 0.0159 0.0565 0.0312 0.0510 0.0243 0.0674 0.0328 0.7880 0.8952 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0039 0.0006 0.0159 0.0128 0.0297 0.0253 0.0244 0.0131 0.0304 0.0186 0.8956 0.9295 0.0066 0.0137 0.0088 0.0274 0.0243 0.0959 0.0133 0.0959 0.0575 0.2055 0.0973 0.1507 0.0619 0.1096 0.0841 0.1507 0.6460 0.1507 0.0012 0.0000 0.0025 0.0204 0.0532 0.0835 0.0884 0.1070 0.6438 8 9 11 12 14 19 46 78 131 0.2066 2.60 3.143 0.7617 7171.8
1810000
603000000
239000000000
0.5155 0.1378 0.0352 0.0029 0.0580 0.0155 0.0890 0.0638 0.1201 0.0629 0.1532 0.0977 0.1636 0.1460 0.1822 0.1199 0.1387 0.1586 0.0600 0.3327 0.0007 0.0007 0.0014 0.0020 0.0021 0.0029 0.0064 0.0085 0.0152 0.0186 0.0258 0.0232 0.0237 0.0235 0.0488 0.0405 0.8759 0.8803 0.0017 0.0015 0.0009 0.0039 0.0064 0.0064 0.0111 0.0148 0.0273 0.0261 0.0413 0.0542 0.0388 0.0473 0.0725 0.0719 0.8001 0.7740 0.0008 0.0008 0.0035 0.0096 0.0207 0.0261 0.0337 0.0560 0.8489
MDA-MB-231 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 182 324 image if available 4862 8847 382.1 46.56 84.31 223.89 321 348 363 376 385 395 406 419 440 0.0849 751 0.869 141.40 42.45 2 0.0755 367 0.0020 27.89 6.580 0.2423 148135.0
58200000
23200000000
9310000000000
0.4327 0.2087 0.0002 0.0000 0.0002 0.0000 0.0009 0.0000 0.0044 0.0000 0.0215 0.0134 0.0430 0.0245 0.0423 0.0117 0.0642 0.0210 0.8233 0.9294 0.0002 0.0000 0.0002 0.0000 0.0000 0.0000 0.0018 0.0000 0.0153 0.0134 0.0306 0.0245 0.0237 0.0117 0.0317 0.0210 0.8966 0.9294 0.0214 0.0000 0.0856 0.0000 0.1016 0.0000 0.1283 0.0000 0.1176 0.0000 0.1444 0.0000 0.1016 0.0000 0.1123 0.0000 0.1872 0.0000 0.0019 0.0049 0.0106 0.0314 0.0538 0.0947 0.0981 0.1163 0.5883 8 9 11 12 13 15 20 43 199 0.1434 6.44 2.531 0.5616 57228.9
60400000
73600000000
96900000000000
0.7057 0.0462 0.0466 0.0000 0.0975 0.0157 0.2458 0.0747 0.1144 0.1041 0.1653 0.1434 0.1483 0.1945 0.1102 0.1611 0.0466 0.1336 0.0254 0.1729 0.0007 0.0000 0.0000 0.0012 0.0014 0.0048 0.0144 0.0133 0.0390 0.0387 0.0787 0.0678 0.0568 0.0599 0.1026 0.0998 0.7066 0.7145 0.0000 0.0000 0.0000 0.0035 0.0016 0.0009 0.0122 0.0192 0.0636 0.0603 0.0865 0.0857 0.0530 0.0594 0.1117 0.0970 0.6713 0.6740 0.0000 0.0008 0.0023 0.0129 0.0530 0.0802 0.0560 0.1104 0.6846
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 353 558 image if available 3264 13261 567.7 97.23 20.25 30.53 423 480 524 555 578 601 624 651 686 0.0525 696 0.829 83.26 24.17 2 0.0757 247 0.0012 24.55 6.947 0.2311 331741.0
199000000
122000000000
75900000000000
0.3761 0.2603 0.0000 0.0000 0.0000 0.0000 0.0013 0.0000 0.0042 0.0015 0.0348 0.0117 0.0809 0.0329 0.0637 0.0151 0.0926 0.0194 0.7227 0.9195 0.0000 0.0000 0.0000 0.0000 0.0007 0.0000 0.0018 0.0012 0.0138 0.0117 0.0348 0.0322 0.0210 0.0129 0.0246 0.0169 0.9033 0.9251 0.0000 0.0000 0.0134 0.0000 0.0267 0.0000 0.0829 0.2000 0.1337 0.2000 0.2086 0.2000 0.1310 0.2000 0.1230 0.2000 0.2807 0.0000 0.0000 0.0011 0.0022 0.0117 0.0458 0.1011 0.0844 0.1000 0.6536 6 8 9 10 11 13 15 19 43 0.3560 0.58 1.966 0.8565 1342.4
217327
52700000
15600000000
0.5872 0.1138 0.0827 0.0402 0.0911 0.0460 0.0905 0.0583 0.1079 0.0708 0.1235 0.1009 0.1307 0.1071 0.1589 0.1225 0.1457 0.1493 0.0689 0.3048 0.0327 0.0279 0.0346 0.0300 0.0335 0.0375 0.0372 0.0451 0.0380 0.0643 0.0515 0.0758 0.0560 0.0781 0.0861 0.0967 0.6304 0.5445 0.0142 0.0053 0.0137 0.0053 0.0132 0.0107 0.0179 0.0165 0.0189 0.0256 0.0344 0.0373 0.0387 0.0453 0.0783 0.0719 0.7708 0.7821 0.0197 0.0239 0.0239 0.0337 0.0322 0.0405 0.0348 0.0594 0.7319