High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
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Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
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MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 445 | 885 | 6720 | 10576 | 145.0 | 36.97 | 295.37 | 234.47 | 104 | 115 | 123 | 131 | 139 | 148 | 158 | 172 | 194 | 0.1029 | 1088 | 0.626 | 198.72 | 50.01 | 1 | 0.0999 | 671 | 0.0017 | 31.55 | 6.712 | 0.2250 | 22380.3 | 3690000 | 653000000 | 124000000000 | 0.4622 | 0.1938 | 0.0005 | 0.0000 | 0.0030 | 0.0002 | 0.0103 | 0.0013 | 0.0323 | 0.0038 | 0.0867 | 0.0230 | 0.1608 | 0.0551 | 0.1817 | 0.0633 | 0.1822 | 0.0935 | 0.3425 | 0.7598 | 0.0004 | 0.0000 | 0.0019 | 0.0002 | 0.0023 | 0.0009 | 0.0120 | 0.0021 | 0.0362 | 0.0137 | 0.0734 | 0.0334 | 0.0766 | 0.0241 | 0.1038 | 0.0442 | 0.6935 | 0.8815 | 0.0071 | 0.0081 | 0.0063 | 0.0444 | 0.0205 | 0.0282 | 0.0947 | 0.1290 | 0.1539 | 0.1673 | 0.1902 | 0.1714 | 0.1200 | 0.0968 | 0.1350 | 0.1310 | 0.2723 | 0.2238 | 0.0007 | 0.0044 | 0.0119 | 0.0408 | 0.0983 | 0.1353 | 0.1272 | 0.1452 | 0.4362 | 37 | 76 | 126 | 181 | 247 | 316 | 392 | 484 | 624 | 0.0023 | 85.50 | 7.315 | 0.2151 | 142212.0 | 87400000 | 63000000000 | 51000000000000 | 0.5432 | 0.1364 | 0.0279 | 0.0023 | 0.1381 | 0.0113 | 0.2587 | 0.0476 | 0.1904 | 0.1232 | 0.1774 | 0.1886 | 0.1211 | 0.2083 | 0.0551 | 0.1398 | 0.0244 | 0.1359 | 0.0068 | 0.1429 | 0.0004 | 0.0002 | 0.0022 | 0.0026 | 0.0044 | 0.0034 | 0.0196 | 0.0138 | 0.0714 | 0.0585 | 0.1250 | 0.1079 | 0.1052 | 0.0792 | 0.1248 | 0.1135 | 0.5471 | 0.6207 | 0.0022 | 0.0031 | 0.0054 | 0.0083 | 0.0165 | 0.0211 | 0.0326 | 0.0418 | 0.0979 | 0.1017 | 0.1600 | 0.1663 | 0.1128 | 0.1228 | 0.1279 | 0.1459 | 0.4447 | 0.3890 | 0.0009 | 0.0046 | 0.0110 | 0.0265 | 0.0867 | 0.1423 | 0.1125 | 0.1244 | 0.4912 | |
MCF7 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 367 | 527 | 14166 | 30978 | 166.3 | 51.48 | 150.74 | 180.13 | 108 | 123 | 136 | 147 | 158 | 171 | 186 | 207 | 241 | 0.0455 | 1410 | 1.186 | 107.56 | 39.85 | 4 | 0.0193 | 274 | 0.0029 | 11.78 | 6.212 | 0.3232 | 30318.4 | 6020000 | 1290000000 | 298000000000 | 0.4567 | 0.2012 | 0.0010 | 0.0002 | 0.0020 | 0.0003 | 0.0095 | 0.0011 | 0.0293 | 0.0063 | 0.0939 | 0.0301 | 0.1627 | 0.0648 | 0.1523 | 0.0591 | 0.1747 | 0.0901 | 0.3747 | 0.7480 | 0.0004 | 0.0000 | 0.0004 | 0.0001 | 0.0027 | 0.0002 | 0.0099 | 0.0021 | 0.0378 | 0.0155 | 0.0638 | 0.0296 | 0.0626 | 0.0267 | 0.0911 | 0.0439 | 0.7313 | 0.8820 | 0.0021 | 0.0018 | 0.0049 | 0.0083 | 0.0147 | 0.0155 | 0.0350 | 0.0596 | 0.0936 | 0.1173 | 0.1393 | 0.1757 | 0.0967 | 0.1203 | 0.1362 | 0.1471 | 0.4774 | 0.3544 | 0.0008 | 0.0034 | 0.0088 | 0.0319 | 0.0709 | 0.1074 | 0.0856 | 0.1046 | 0.5866 | 8 | 10 | 15 | 33 | 75 | 129 | 195 | 283 | 413 | 0.0651 | 14.33 | 5.012 | 0.4997 | 55169.9 | 27400000 | 16300000000 | 11100000000000 | 0.5068 | 0.1638 | 0.0376 | 0.0026 | 0.1800 | 0.0101 | 0.2471 | 0.0930 | 0.1592 | 0.1413 | 0.1404 | 0.1940 | 0.1108 | 0.1938 | 0.0625 | 0.1310 | 0.0393 | 0.1131 | 0.0232 | 0.1211 | 0.0002 | 0.0002 | 0.0005 | 0.0001 | 0.0016 | 0.0012 | 0.0097 | 0.0069 | 0.0522 | 0.0426 | 0.0886 | 0.0730 | 0.0686 | 0.0557 | 0.1054 | 0.0879 | 0.6732 | 0.7326 | 0.0004 | 0.0006 | 0.0015 | 0.0020 | 0.0027 | 0.0051 | 0.0177 | 0.0220 | 0.0740 | 0.0904 | 0.1206 | 0.1278 | 0.0882 | 0.0952 | 0.1271 | 0.1330 | 0.5678 | 0.5239 | 0.0000 | 0.0020 | 0.0028 | 0.0144 | 0.0620 | 0.1077 | 0.0815 | 0.1152 | 0.6146 | |
MDA-MB-231 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 434 | 702 | 366 | 1008 | 101.8 | 15.33 | 117.32 | 181.93 | 80 | 86 | 92 | 98 | 103 | 108 | 111 | 115 | 124 | 0.2123 | 214 | 1.232 | 111.40 | 47.13 | 1 | 0.7978 | 292 | 0.0164 | 2.19 | 4.307 | 0.5322 | 10587.6 | 1130000 | 122000000 | 13400000000 | 0.3074 | 0.3364 | 0.0000 | 0.0000 | 0.0035 | 0.0000 | 0.0000 | 0.0000 | 0.0211 | 0.0055 | 0.0526 | 0.0437 | 0.1719 | 0.1202 | 0.0842 | 0.0328 | 0.0982 | 0.0437 | 0.5684 | 0.7541 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0123 | 0.0055 | 0.0401 | 0.0437 | 0.1204 | 0.1202 | 0.0432 | 0.0328 | 0.0401 | 0.0437 | 0.7438 | 0.7541 | 0.0000 | 0.0000 | 0.0256 | 0.0000 | 0.0256 | 0.0000 | 0.1026 | 0.0000 | 0.1026 | 0.0000 | 0.2051 | 0.0000 | 0.1026 | 0.0000 | 0.2308 | 0.0000 | 0.2051 | 0.0000 | 0.0000 | 0.0000 | 0.0158 | 0.0263 | 0.0526 | 0.1316 | 0.0842 | 0.0947 | 0.5947 | 11 | 13 | 15 | 21 | 33 | 58 | 109 | 190 | 334 | 0.1012 | 55.96 | 4.139 | 0.5623 | 46830.7 | 29000000 | 21700000000 | 18100000000000 | 0.4240 | 0.1879 | 0.1642 | 0.0070 | 0.2537 | 0.0986 | 0.1642 | 0.1690 | 0.1493 | 0.1408 | 0.1194 | 0.1408 | 0.0896 | 0.1620 | 0.0448 | 0.1056 | 0.0149 | 0.0986 | 0.0000 | 0.0775 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0061 | 0.0027 | 0.0457 | 0.0348 | 0.0793 | 0.0668 | 0.1250 | 0.1364 | 0.0854 | 0.0668 | 0.1494 | 0.1337 | 0.5091 | 0.5588 | 0.0000 | 0.0043 | 0.0038 | 0.0086 | 0.0268 | 0.0172 | 0.0345 | 0.0302 | 0.1188 | 0.1207 | 0.1341 | 0.1466 | 0.0996 | 0.1034 | 0.1533 | 0.1767 | 0.4291 | 0.3922 | 0.0000 | 0.0035 | 0.0177 | 0.0389 | 0.0989 | 0.1272 | 0.1095 | 0.1484 | 0.4558 | |
MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 534 | 923 | 4850 | 8622 | 162.0 | 44.63 | 180.98 | 189.76 | 115 | 127 | 136 | 144 | 153 | 163 | 176 | 194 | 220 | 0.0923 | 796 | 1.107 | 100.01 | 36.69 | 1 | 0.0542 | 263 | 0.0016 | 35.56 | 6.803 | 0.2042 | 28220.0 | 5320000 | 1090000000 | 244000000000 | 0.4589 | 0.1995 | 0.0007 | 0.0000 | 0.0029 | 0.0005 | 0.0119 | 0.0016 | 0.0353 | 0.0018 | 0.0965 | 0.0224 | 0.1780 | 0.0576 | 0.1567 | 0.0576 | 0.1780 | 0.0908 | 0.3401 | 0.7676 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0024 | 0.0000 | 0.0113 | 0.0004 | 0.0464 | 0.0146 | 0.0848 | 0.0310 | 0.0754 | 0.0240 | 0.1095 | 0.0437 | 0.6690 | 0.8863 | 0.0021 | 0.0124 | 0.0095 | 0.0173 | 0.0148 | 0.0173 | 0.0674 | 0.0990 | 0.1349 | 0.1708 | 0.1802 | 0.1931 | 0.1117 | 0.0990 | 0.1454 | 0.1411 | 0.3340 | 0.2500 | 0.0025 | 0.0020 | 0.0129 | 0.0373 | 0.0821 | 0.1318 | 0.1035 | 0.1274 | 0.5005 | 14 | 24 | 41 | 71 | 110 | 159 | 230 | 325 | 469 | 0.0065 | 92.57 | 6.832 | 0.2972 | 68756.7 | 35000000 | 20900000000 | 13800000000000 | 0.4654 | 0.1787 | 0.0372 | 0.0015 | 0.1157 | 0.0126 | 0.2314 | 0.0576 | 0.2038 | 0.0919 | 0.1826 | 0.1859 | 0.1210 | 0.2273 | 0.0605 | 0.1485 | 0.0297 | 0.1348 | 0.0180 | 0.1399 | 0.0011 | 0.0005 | 0.0019 | 0.0018 | 0.0057 | 0.0016 | 0.0164 | 0.0127 | 0.0655 | 0.0540 | 0.0911 | 0.0881 | 0.0668 | 0.0623 | 0.0898 | 0.0865 | 0.6617 | 0.6924 | 0.0018 | 0.0000 | 0.0015 | 0.0081 | 0.0066 | 0.0098 | 0.0239 | 0.0242 | 0.0668 | 0.0752 | 0.1146 | 0.1134 | 0.0856 | 0.0935 | 0.1050 | 0.1143 | 0.5942 | 0.5616 | 0.0003 | 0.0028 | 0.0070 | 0.0215 | 0.0579 | 0.0958 | 0.0730 | 0.1078 | 0.6339 | |||
BT-20 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 895 | 228 | 1426 | 7457 | 297.1 | 74.97 | 7.35 | 3.00 | 208 | 227 | 244 | 263 | 287 | 309 | 333 | 361 | 411 | 0.0758 | 565 | 1.060 | 52.39 | 17.09 | 1 | 0.0912 | 130 | 0.0050 | 5.81 | 5.550 | 0.3967 | 93879.8 | 31500000 | 11200000000 | 4160000000000 | 0.4025 | 0.2290 | 0.0000 | 0.0000 | 0.0000 | 0.0015 | 0.0040 | 0.0008 | 0.0374 | 0.0038 | 0.0602 | 0.0369 | 0.0989 | 0.0638 | 0.0936 | 0.0430 | 0.1283 | 0.0692 | 0.5775 | 0.7809 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0010 | 0.0000 | 0.0171 | 0.0007 | 0.0286 | 0.0288 | 0.0390 | 0.0400 | 0.0448 | 0.0204 | 0.0524 | 0.0435 | 0.8171 | 0.8667 | 0.0000 | 0.0000 | 0.0066 | 0.0161 | 0.0166 | 0.0000 | 0.0364 | 0.0242 | 0.0530 | 0.1694 | 0.0629 | 0.1774 | 0.0927 | 0.0806 | 0.1060 | 0.2339 | 0.6258 | 0.2984 | 0.0016 | 0.0016 | 0.0109 | 0.0203 | 0.0422 | 0.0422 | 0.0703 | 0.0766 | 0.7344 | 4 | 5 | 6 | 6 | 7 | 7 | 8 | 9 | 11 | 0.0171 | 9.64 | 4.604 | 0.3424 | 63.0 | 623.07 | 7074.44 | 91176.4 | 0.4927 | 0.1584 | 0.0077 | 0.0045 | 0.0406 | 0.0095 | 0.0981 | 0.0305 | 0.1678 | 0.0652 | 0.2278 | 0.1209 | 0.2100 | 0.1971 | 0.1593 | 0.2556 | 0.0768 | 0.2221 | 0.0121 | 0.0947 | 0.0010 | 0.0002 | 0.0055 | 0.0018 | 0.0185 | 0.0077 | 0.0480 | 0.0279 | 0.0854 | 0.0599 | 0.1434 | 0.1145 | 0.1875 | 0.1703 | 0.2216 | 0.2463 | 0.2890 | 0.3715 | 0.1040 | 0.1438 | 0.1361 | 0.1222 | 0.1301 | 0.0872 | 0.0853 | 0.0745 | 0.0895 | 0.1058 | 0.0811 | 0.0857 | 0.0956 | 0.0842 | 0.0923 | 0.1170 | 0.1860 | 0.1796 | 0.0135 | 0.0521 | 0.0974 | 0.1372 | 0.1573 | 0.1377 | 0.1213 | 0.1143 | 0.1691 | |
MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 1098 | 245 | 11985 | 25048 | 84.9 | 24.68 | 210.46 | 174.39 | 57 | 66 | 72 | 78 | 83 | 89 | 96 | 104 | 117 | 0.0493 | 1235 | 1.212 | 170.77 | 60.46 | 3 | 0.0339 | 406 | 0.0035 | 11.99 | 6.022 | 0.3238 | 7822.1 | 773291 | 81600000 | 9180000000 | 0.4646 | 0.2016 | 0.0015 | 0.0001 | 0.0035 | 0.0002 | 0.0189 | 0.0013 | 0.0497 | 0.0060 | 0.0986 | 0.0268 | 0.1577 | 0.0599 | 0.1701 | 0.0693 | 0.1916 | 0.1035 | 0.3083 | 0.7329 | 0.0005 | 0.0000 | 0.0011 | 0.0001 | 0.0039 | 0.0001 | 0.0150 | 0.0019 | 0.0339 | 0.0136 | 0.0662 | 0.0303 | 0.0676 | 0.0255 | 0.0968 | 0.0435 | 0.7150 | 0.8851 | 0.0033 | 0.0121 | 0.0080 | 0.0260 | 0.0256 | 0.0419 | 0.0756 | 0.1200 | 0.1388 | 0.1842 | 0.1465 | 0.1777 | 0.1385 | 0.1284 | 0.1600 | 0.1265 | 0.3036 | 0.1833 | 0.0009 | 0.0050 | 0.0135 | 0.0414 | 0.0740 | 0.1119 | 0.1069 | 0.1367 | 0.5097 | 27 | 50 | 85 | 129 | 174 | 220 | 274 | 342 | 444 | 0.0030 | 74.43 | 7.191 | 0.2347 | 74701.9 | 35300000 | 20500000000 | 14000000000000 | 0.4914 | 0.1942 | 0.0341 | 0.0005 | 0.1480 | 0.0067 | 0.2568 | 0.0741 | 0.1712 | 0.1263 | 0.1455 | 0.1772 | 0.1169 | 0.1937 | 0.0654 | 0.1449 | 0.0389 | 0.1300 | 0.0232 | 0.1465 | 0.0003 | 0.0001 | 0.0016 | 0.0005 | 0.0037 | 0.0012 | 0.0153 | 0.0094 | 0.0721 | 0.0542 | 0.1302 | 0.1070 | 0.0998 | 0.0805 | 0.1378 | 0.1181 | 0.5392 | 0.6290 | 0.0009 | 0.0021 | 0.0040 | 0.0065 | 0.0122 | 0.0178 | 0.0377 | 0.0512 | 0.1055 | 0.1206 | 0.1719 | 0.1793 | 0.1135 | 0.1149 | 0.1437 | 0.1477 | 0.4105 | 0.3599 | 0.0007 | 0.0020 | 0.0080 | 0.0239 | 0.0873 | 0.1563 | 0.1162 | 0.1382 | 0.4675 | |
MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 1075 | 895 | 4118 | 4934 | 145.3 | 36.15 | 206.60 | 178.21 | 103 | 116 | 125 | 133 | 141 | 149 | 158 | 171 | 192 | 0.1336 | 659 | 0.978 | 89.59 | 26.42 | 1 | 0.0529 | 218 | 0.0019 | 27.36 | 6.598 | 0.2315 | 22405.4 | 3670000 | 641000000 | 119000000000 | 0.4147 | 0.2407 | 0.0000 | 0.0000 | 0.0015 | 0.0000 | 0.0093 | 0.0003 | 0.0201 | 0.0030 | 0.0872 | 0.0280 | 0.1515 | 0.0560 | 0.1519 | 0.0633 | 0.1709 | 0.0810 | 0.4076 | 0.7684 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0024 | 0.0000 | 0.0060 | 0.0007 | 0.0400 | 0.0177 | 0.0771 | 0.0337 | 0.0689 | 0.0327 | 0.0915 | 0.0434 | 0.7140 | 0.8718 | 0.0013 | 0.0068 | 0.0067 | 0.0136 | 0.0324 | 0.0306 | 0.0931 | 0.1054 | 0.1242 | 0.1667 | 0.1768 | 0.1939 | 0.1188 | 0.1224 | 0.1174 | 0.1361 | 0.3293 | 0.2245 | 0.0005 | 0.0037 | 0.0095 | 0.0349 | 0.1138 | 0.1376 | 0.1027 | 0.1466 | 0.4505 | 24 | 53 | 88 | 122 | 160 | 204 | 256 | 333 | 460 | 0.0021 | 74.59 | 7.103 | 0.2341 | 74435.4 | 36000000 | 21000000000 | 13800000000000 | 0.4404 | 0.2138 | 0.0141 | 0.0018 | 0.0633 | 0.0084 | 0.1547 | 0.0349 | 0.1864 | 0.0699 | 0.1934 | 0.1470 | 0.1536 | 0.1946 | 0.1313 | 0.1524 | 0.0610 | 0.1837 | 0.0422 | 0.2072 | 0.0012 | 0.0003 | 0.0033 | 0.0024 | 0.0067 | 0.0058 | 0.0158 | 0.0151 | 0.0596 | 0.0599 | 0.0979 | 0.0767 | 0.0870 | 0.0712 | 0.1083 | 0.1070 | 0.6202 | 0.6615 | 0.0013 | 0.0024 | 0.0071 | 0.0040 | 0.0110 | 0.0176 | 0.0323 | 0.0353 | 0.0788 | 0.0842 | 0.1072 | 0.1259 | 0.0969 | 0.0874 | 0.1111 | 0.1115 | 0.5543 | 0.5317 | 0.0026 | 0.0026 | 0.0067 | 0.0231 | 0.0817 | 0.0966 | 0.0910 | 0.1182 | 0.5776 | |||
BT-20 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 343 | 200 | 878 | 6143 | 525.5 | 135.86 | 10.24 | 3.28 | 368 | 395 | 421 | 455 | 499 | 554 | 604 | 666 | 723 | 0.0754 | 463 | 0.604 | 47.54 | 9.06 | 1 | 0.1378 | 121 | 0.0024 | 16.27 | 6.196 | 0.2529 | 294575.0 | 175000000 | 110000000000 | 72000000000000 | 0.3830 | 0.2519 | 0.0025 | 0.0000 | 0.0000 | 0.0000 | 0.0100 | 0.0000 | 0.0375 | 0.0012 | 0.0725 | 0.0436 | 0.1350 | 0.0711 | 0.1250 | 0.0436 | 0.1575 | 0.0748 | 0.4600 | 0.7656 | 0.0016 | 0.0000 | 0.0000 | 0.0000 | 0.0048 | 0.0000 | 0.0194 | 0.0011 | 0.0387 | 0.0285 | 0.0452 | 0.0582 | 0.0516 | 0.0228 | 0.0613 | 0.0433 | 0.7774 | 0.8461 | 0.0000 | 0.0133 | 0.0000 | 0.0000 | 0.0091 | 0.0000 | 0.0136 | 0.0400 | 0.0500 | 0.1467 | 0.1045 | 0.0533 | 0.0409 | 0.1467 | 0.1000 | 0.1200 | 0.6818 | 0.4800 | 0.0000 | 0.0000 | 0.0000 | 0.0051 | 0.0558 | 0.0685 | 0.0482 | 0.0635 | 0.7589 | 6 | 8 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 0.0096 | 13.75 | 5.010 | 0.2956 | 115.7 | 1428.61 | 19209.6 | 280803 | 0.4694 | 0.1709 | 0.0114 | 0.0012 | 0.0485 | 0.0043 | 0.1058 | 0.0137 | 0.1831 | 0.0308 | 0.2262 | 0.0599 | 0.2172 | 0.1118 | 0.1379 | 0.2167 | 0.0576 | 0.3023 | 0.0124 | 0.2592 | 0.0018 | 0.0000 | 0.0061 | 0.0002 | 0.0167 | 0.0017 | 0.0338 | 0.0093 | 0.0686 | 0.0222 | 0.1093 | 0.0398 | 0.1662 | 0.0718 | 0.2592 | 0.1976 | 0.3384 | 0.6574 | 0.0758 | 0.1652 | 0.1178 | 0.1845 | 0.1375 | 0.1674 | 0.1437 | 0.1330 | 0.1277 | 0.0848 | 0.1313 | 0.0730 | 0.0882 | 0.0655 | 0.0903 | 0.0612 | 0.0877 | 0.0655 | 0.0141 | 0.0392 | 0.0707 | 0.1082 | 0.1172 | 0.1593 | 0.1694 | 0.1593 | 0.1625 | |
MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 880 | 885 | 10209 | 13674 | 210.6 | 64.74 | 239.98 | 269.86 | 139 | 157 | 172 | 186 | 201 | 218 | 235 | 258 | 290 | 0.0808 | 1105 | 1.151 | 67.48 | 26.42 | 6 | 0.0172 | 176 | 0.0007 | 71.44 | 7.552 | 0.1615 | 48539.4 | 12300000 | 3450000000 | 1070000000000 | 0.4221 | 0.2180 | 0.0004 | 0.0000 | 0.0033 | 0.0003 | 0.0115 | 0.0010 | 0.0376 | 0.0028 | 0.1041 | 0.0279 | 0.1913 | 0.0622 | 0.1747 | 0.0675 | 0.1796 | 0.0979 | 0.2975 | 0.7403 | 0.0003 | 0.0000 | 0.0012 | 0.0000 | 0.0033 | 0.0005 | 0.0121 | 0.0017 | 0.0372 | 0.0177 | 0.0738 | 0.0313 | 0.0693 | 0.0305 | 0.0883 | 0.0432 | 0.7146 | 0.8751 | 0.0023 | 0.0091 | 0.0059 | 0.0136 | 0.0135 | 0.0385 | 0.0594 | 0.1145 | 0.1256 | 0.1531 | 0.1953 | 0.1803 | 0.1085 | 0.0918 | 0.1472 | 0.1168 | 0.3425 | 0.2823 | 0.0007 | 0.0027 | 0.0067 | 0.0258 | 0.0734 | 0.1232 | 0.1052 | 0.1252 | 0.5371 | 16 | 23 | 40 | 77 | 135 | 211 | 305 | 429 | 627 | 0.0143 | 119.92 | 6.776 | 0.3161 | 130409.0 | 96900000 | 85800000000 | 85400000000000 | 0.5316 | 0.1438 | 0.0357 | 0.0030 | 0.1564 | 0.0135 | 0.2778 | 0.0912 | 0.1687 | 0.1243 | 0.1317 | 0.1676 | 0.1036 | 0.1912 | 0.0617 | 0.1297 | 0.0418 | 0.1132 | 0.0226 | 0.1662 | 0.0003 | 0.0004 | 0.0016 | 0.0009 | 0.0038 | 0.0034 | 0.0135 | 0.0085 | 0.0587 | 0.0479 | 0.1129 | 0.0936 | 0.0741 | 0.0654 | 0.1097 | 0.0915 | 0.6255 | 0.6882 | 0.0009 | 0.0013 | 0.0032 | 0.0051 | 0.0090 | 0.0105 | 0.0254 | 0.0239 | 0.0757 | 0.0826 | 0.1232 | 0.1313 | 0.0868 | 0.0987 | 0.1179 | 0.1229 | 0.5578 | 0.5235 | 0.0000 | 0.0022 | 0.0066 | 0.0179 | 0.0664 | 0.1252 | 0.0814 | 0.1093 | 0.5910 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 831 | 627 | 22430 | 35732 | 126.0 | 38.62 | 252.74 | 227.53 | 82 | 95 | 104 | 113 | 121 | 131 | 142 | 157 | 179 | 0.0532 | 1901 | 0.880 | 73.43 | 20.81 | 2 | 0.0089 | 200 | 0.0017 | 21.99 | 6.753 | 0.2609 | 17379.7 | 2600000 | 417000000 | 71800000000 | 0.4412 | 0.2102 | 0.0006 | 0.0001 | 0.0021 | 0.0002 | 0.0088 | 0.0011 | 0.0346 | 0.0052 | 0.1045 | 0.0291 | 0.1823 | 0.0693 | 0.1643 | 0.0693 | 0.1767 | 0.0997 | 0.3261 | 0.7259 | 0.0002 | 0.0001 | 0.0008 | 0.0001 | 0.0022 | 0.0002 | 0.0101 | 0.0018 | 0.0357 | 0.0141 | 0.0709 | 0.0319 | 0.0688 | 0.0258 | 0.0917 | 0.0432 | 0.7197 | 0.8826 | 0.0034 | 0.0054 | 0.0050 | 0.0100 | 0.0140 | 0.0284 | 0.0533 | 0.0888 | 0.0998 | 0.1568 | 0.1659 | 0.2106 | 0.1164 | 0.1172 | 0.1451 | 0.1426 | 0.3972 | 0.2402 | 0.0011 | 0.0034 | 0.0087 | 0.0271 | 0.0720 | 0.1160 | 0.1006 | 0.1196 | 0.5516 | 16 | 33 | 75 | 138 | 204 | 273 | 343 | 432 | 576 | 0.0082 | 55.93 | 6.842 | 0.3237 | 115644.0 | 68100000 | 47400000000 | 37300000000000 | 0.5184 | 0.1555 | 0.0294 | 0.0010 | 0.1132 | 0.0078 | 0.2146 | 0.0613 | 0.1758 | 0.0954 | 0.1640 | 0.1647 | 0.1397 | 0.1993 | 0.0852 | 0.1472 | 0.0476 | 0.1393 | 0.0304 | 0.1840 | 0.0000 | 0.0002 | 0.0006 | 0.0007 | 0.0018 | 0.0015 | 0.0125 | 0.0070 | 0.0472 | 0.0386 | 0.0990 | 0.0797 | 0.0795 | 0.0590 | 0.1063 | 0.0906 | 0.6532 | 0.7227 | 0.0006 | 0.0013 | 0.0027 | 0.0029 | 0.0077 | 0.0109 | 0.0241 | 0.0340 | 0.0806 | 0.1011 | 0.1356 | 0.1539 | 0.1094 | 0.1178 | 0.1359 | 0.1438 | 0.5033 | 0.4344 | 0.0003 | 0.0016 | 0.0049 | 0.0169 | 0.0624 | 0.1189 | 0.0930 | 0.1202 | 0.5819 | |
MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 271 | 234 | 4849 | 8509 | 138.5 | 37.61 | 168.08 | 116.27 | 97 | 108 | 116 | 125 | 133 | 143 | 153 | 166 | 185 | 0.0903 | 768 | 0.853 | 97.87 | 27.20 | 1 | 0.0524 | 254 | 0.0019 | 23.69 | 6.561 | 0.2428 | 20609.1 | 3310000 | 576000000 | 109000000000 | 0.4479 | 0.1970 | 0.0011 | 0.0000 | 0.0041 | 0.0000 | 0.0103 | 0.0007 | 0.0347 | 0.0030 | 0.0975 | 0.0240 | 0.1680 | 0.0552 | 0.1473 | 0.0550 | 0.1743 | 0.0965 | 0.3626 | 0.7657 | 0.0005 | 0.0000 | 0.0022 | 0.0000 | 0.0030 | 0.0000 | 0.0123 | 0.0013 | 0.0355 | 0.0161 | 0.0695 | 0.0309 | 0.0711 | 0.0237 | 0.0993 | 0.0428 | 0.7066 | 0.8852 | 0.0042 | 0.0206 | 0.0084 | 0.0413 | 0.0190 | 0.0324 | 0.0685 | 0.1150 | 0.1496 | 0.1711 | 0.1707 | 0.1917 | 0.1201 | 0.1003 | 0.1465 | 0.0944 | 0.3130 | 0.2330 | 0.0009 | 0.0047 | 0.0117 | 0.0314 | 0.0835 | 0.1234 | 0.1183 | 0.1427 | 0.4833 | 38 | 66 | 89 | 113 | 143 | 180 | 216 | 263 | 330 | 0.0018 | 46.51 | 6.975 | 0.2588 | 41766.1 | 13000000 | 4740000000 | 1930000000000 | 0.4999 | 0.1620 | 0.0124 | 0.0018 | 0.0599 | 0.0036 | 0.1785 | 0.0173 | 0.2094 | 0.0574 | 0.1872 | 0.1344 | 0.1408 | 0.2044 | 0.0982 | 0.1652 | 0.0624 | 0.1709 | 0.0513 | 0.2450 | 0.0000 | 0.0005 | 0.0009 | 0.0009 | 0.0025 | 0.0038 | 0.0156 | 0.0096 | 0.0467 | 0.0356 | 0.0847 | 0.0597 | 0.0774 | 0.0637 | 0.1241 | 0.0957 | 0.6481 | 0.7305 | 0.0014 | 0.0023 | 0.0028 | 0.0064 | 0.0084 | 0.0138 | 0.0298 | 0.0527 | 0.0922 | 0.1087 | 0.1388 | 0.1577 | 0.1247 | 0.1220 | 0.1496 | 0.1298 | 0.4523 | 0.4067 | 0.0000 | 0.0008 | 0.0024 | 0.0176 | 0.0680 | 0.1114 | 0.0973 | 0.1403 | 0.5622 | |||
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 766 | 509 | 21316 | 24107 | 152.8 | 47.18 | 163.56 | 211.64 | 92 | 112 | 127 | 140 | 153 | 165 | 177 | 192 | 213 | 0.1036 | 2498 | 0.827 | 32.25 | 8.06 | 7 | 0.0040 | 86 | 0.0005 | 77.74 | 7.966 | 0.1418 | 25560.0 | 4600000 | 879000000 | 178000000000 | 0.4877 | 0.1525 | 0.0009 | 0.0000 | 0.0037 | 0.0002 | 0.0149 | 0.0010 | 0.0428 | 0.0072 | 0.1047 | 0.0330 | 0.1809 | 0.0736 | 0.1588 | 0.0762 | 0.1780 | 0.0986 | 0.3152 | 0.7103 | 0.0003 | 0.0000 | 0.0008 | 0.0001 | 0.0020 | 0.0004 | 0.0097 | 0.0036 | 0.0325 | 0.0180 | 0.0642 | 0.0375 | 0.0588 | 0.0332 | 0.0797 | 0.0428 | 0.7519 | 0.8643 | 0.0029 | 0.0050 | 0.0051 | 0.0208 | 0.0156 | 0.0337 | 0.0478 | 0.0972 | 0.1088 | 0.1622 | 0.1603 | 0.2009 | 0.1202 | 0.1275 | 0.1473 | 0.1314 | 0.3919 | 0.2212 | 0.0008 | 0.0017 | 0.0048 | 0.0220 | 0.0553 | 0.0994 | 0.0941 | 0.1118 | 0.6100 | 16 | 20 | 29 | 40 | 58 | 89 | 164 | 305 | 506 | 0.0680 | 12.41 | 4.640 | 0.6115 | 71539.6 | 42800000 | 29400000000 | 22000000000000 | 0.5538 | 0.1336 | 0.0351 | 0.0046 | 0.1280 | 0.0167 | 0.2120 | 0.0578 | 0.1783 | 0.0940 | 0.1652 | 0.1624 | 0.1225 | 0.1970 | 0.0736 | 0.1265 | 0.0427 | 0.1262 | 0.0427 | 0.2147 | 0.0004 | 0.0008 | 0.0014 | 0.0014 | 0.0027 | 0.0031 | 0.0150 | 0.0104 | 0.0386 | 0.0411 | 0.0622 | 0.0561 | 0.0522 | 0.0433 | 0.0703 | 0.0687 | 0.7572 | 0.7752 | 0.0009 | 0.0010 | 0.0030 | 0.0044 | 0.0068 | 0.0054 | 0.0149 | 0.0123 | 0.0452 | 0.0465 | 0.0647 | 0.0707 | 0.0588 | 0.0625 | 0.0807 | 0.0936 | 0.7250 | 0.7037 | 0.0003 | 0.0026 | 0.0046 | 0.0144 | 0.0427 | 0.0684 | 0.0512 | 0.0708 | 0.7451 | |
MDA-MB-231 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 350 | 768 | 2148 | 7377 | 649.8 | 190.42 | 59.61 | 108.11 | 361 | 467 | 544 | 624 | 689 | 729 | 767 | 811 | 863 | 0.0729 | 538 | 0.439 | 61.06 | 9.22 | 3 | 0.0791 | 170 | 0.0009 | 72.75 | 7.161 | 0.1651 | 458473.0 | 344000000 | 270000000000 | 221000000000000 | 0.4160 | 0.2058 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0050 | 0.0006 | 0.0291 | 0.0023 | 0.0824 | 0.0283 | 0.1568 | 0.0702 | 0.1075 | 0.0385 | 0.1397 | 0.0645 | 0.4794 | 0.7957 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0045 | 0.0016 | 0.0293 | 0.0240 | 0.0560 | 0.0464 | 0.0350 | 0.0235 | 0.0592 | 0.0427 | 0.8160 | 0.8617 | 0.0000 | 0.0094 | 0.0000 | 0.0283 | 0.0035 | 0.0189 | 0.0260 | 0.0566 | 0.0781 | 0.1415 | 0.1163 | 0.2264 | 0.0885 | 0.0472 | 0.1250 | 0.1038 | 0.5625 | 0.3679 | 0.0000 | 0.0000 | 0.0000 | 0.0091 | 0.0432 | 0.0639 | 0.0490 | 0.0763 | 0.7585 | 7 | 9 | 11 | 13 | 16 | 21 | 32 | 64 | 203 | 0.0746 | 10.49 | 3.983 | 0.6307 | 15239.4 | 6560000 | 3660000000 | 2420000000000 | 0.2920 | 0.3302 | 0.0000 | 0.0050 | 0.0655 | 0.0113 | 0.2143 | 0.0239 | 0.2292 | 0.0642 | 0.2054 | 0.1597 | 0.1429 | 0.2013 | 0.0774 | 0.1660 | 0.0506 | 0.1698 | 0.0149 | 0.1987 | 0.0000 | 0.0019 | 0.0017 | 0.0043 | 0.0040 | 0.0038 | 0.0115 | 0.0125 | 0.0340 | 0.0355 | 0.0530 | 0.0485 | 0.0363 | 0.0384 | 0.0594 | 0.0677 | 0.8000 | 0.7872 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0043 | 0.0031 | 0.0129 | 0.0109 | 0.0372 | 0.0427 | 0.0558 | 0.0637 | 0.0393 | 0.0365 | 0.0629 | 0.0637 | 0.7877 | 0.7793 | 0.0000 | 0.0000 | 0.0007 | 0.0170 | 0.0352 | 0.0483 | 0.0463 | 0.0614 | 0.7911 | |
BT-20 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 946 | 255 | 1237 | 5097 | 597.6 | 154.71 | 26.89 | 29.04 | 397 | 436 | 482 | 531 | 589 | 647 | 701 | 753 | 822 | 0.1214 | 619 | 1.247 | 102.24 | 42.95 | 1 | 0.2183 | 270 | 0.0018 | 17.17 | 6.438 | 0.2538 | 381056.0 | 257000000 | 181000000000 | 133000000000000 | 0.3962 | 0.2297 | 0.0000 | 0.0000 | 0.0037 | 0.0009 | 0.0093 | 0.0018 | 0.0223 | 0.0080 | 0.0801 | 0.0312 | 0.1657 | 0.0714 | 0.1192 | 0.0562 | 0.1546 | 0.0714 | 0.4451 | 0.7591 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0008 | 0.0092 | 0.0016 | 0.0264 | 0.0246 | 0.0608 | 0.0493 | 0.0321 | 0.0271 | 0.0585 | 0.0427 | 0.8131 | 0.8539 | 0.0000 | 0.0103 | 0.0000 | 0.0206 | 0.0060 | 0.0412 | 0.0269 | 0.0619 | 0.0716 | 0.1443 | 0.1134 | 0.1753 | 0.0866 | 0.0825 | 0.0925 | 0.1753 | 0.6030 | 0.2887 | 0.0000 | 0.0000 | 0.0000 | 0.0100 | 0.0434 | 0.0634 | 0.0467 | 0.0768 | 0.7596 | 6 | 7 | 8 | 10 | 13 | 19 | 28 | 45 | 74 | 0.1481 | 0.93 | 2.851 | 0.7106 | 1566.2 | 129062 | 12400000 | 1310000000 | 0.4006 | 0.2163 | 0.0291 | 0.0139 | 0.1414 | 0.0268 | 0.2557 | 0.0606 | 0.2370 | 0.1480 | 0.1705 | 0.2205 | 0.1019 | 0.1768 | 0.0437 | 0.1609 | 0.0146 | 0.1231 | 0.0062 | 0.0695 | 0.0016 | 0.0054 | 0.0022 | 0.0054 | 0.0141 | 0.0117 | 0.0255 | 0.0252 | 0.0662 | 0.0667 | 0.0950 | 0.0812 | 0.0787 | 0.0744 | 0.0944 | 0.1019 | 0.6224 | 0.6280 | 0.0029 | 0.0025 | 0.0059 | 0.0033 | 0.0095 | 0.0190 | 0.0352 | 0.0355 | 0.0808 | 0.0809 | 0.0932 | 0.0884 | 0.0712 | 0.0710 | 0.0991 | 0.1057 | 0.6021 | 0.5937 | 0.0025 | 0.0056 | 0.0124 | 0.0324 | 0.0678 | 0.1008 | 0.0716 | 0.0965 | 0.6105 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1218 | 331 | 5158 | 11255 | 109.5 | 27.54 | 210.24 | 157.90 | 76 | 87 | 94 | 101 | 107 | 113 | 121 | 132 | 147 | 0.0888 | 999 | 0.982 | 161.79 | 52.24 | 2 | 0.0812 | 419 | 0.0014 | 32.09 | 6.880 | 0.2109 | 12755.0 | 1570000 | 204000000 | 27800000000 | 0.4280 | 0.2240 | 0.0010 | 0.0000 | 0.0046 | 0.0002 | 0.0137 | 0.0020 | 0.0332 | 0.0061 | 0.0853 | 0.0250 | 0.1439 | 0.0581 | 0.1598 | 0.0664 | 0.1960 | 0.0836 | 0.3626 | 0.7585 | 0.0005 | 0.0000 | 0.0010 | 0.0000 | 0.0032 | 0.0010 | 0.0112 | 0.0022 | 0.0364 | 0.0170 | 0.0670 | 0.0376 | 0.0687 | 0.0309 | 0.1000 | 0.0426 | 0.7120 | 0.8686 | 0.0096 | 0.0140 | 0.0115 | 0.0197 | 0.0239 | 0.0337 | 0.0822 | 0.1489 | 0.1377 | 0.1601 | 0.1424 | 0.1573 | 0.1243 | 0.1433 | 0.1348 | 0.1180 | 0.3337 | 0.2051 | 0.0038 | 0.0059 | 0.0169 | 0.0418 | 0.0823 | 0.1283 | 0.1177 | 0.1346 | 0.4688 | 46 | 78 | 107 | 136 | 168 | 205 | 255 | 330 | 441 | 0.0032 | 32.72 | 6.476 | 0.3151 | 69130.2 | 29900000 | 15400000000 | 9000000000000 | 0.5329 | 0.1282 | 0.0180 | 0.0007 | 0.0912 | 0.0074 | 0.1973 | 0.0320 | 0.1694 | 0.0776 | 0.1551 | 0.1513 | 0.1470 | 0.1874 | 0.0989 | 0.1477 | 0.0755 | 0.1517 | 0.0476 | 0.2442 | 0.0007 | 0.0003 | 0.0018 | 0.0020 | 0.0065 | 0.0043 | 0.0235 | 0.0156 | 0.0685 | 0.0528 | 0.1185 | 0.0846 | 0.0952 | 0.0742 | 0.1250 | 0.1087 | 0.5602 | 0.6575 | 0.0026 | 0.0033 | 0.0058 | 0.0066 | 0.0151 | 0.0147 | 0.0422 | 0.0518 | 0.1013 | 0.1200 | 0.1487 | 0.1637 | 0.1117 | 0.1076 | 0.1414 | 0.1333 | 0.4312 | 0.3990 | 0.0007 | 0.0057 | 0.0119 | 0.0306 | 0.0952 | 0.1313 | 0.1048 | 0.1375 | 0.4823 | |
MCF7 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1083 | 712 | 14567 | 23345 | 228.3 | 65.80 | 245.84 | 294.83 | 149 | 171 | 189 | 204 | 221 | 238 | 259 | 283 | 318 | 0.0544 | 1269 | 0.975 | 95.05 | 27.31 | 2 | 0.0162 | 236 | 0.0009 | 39.78 | 7.247 | 0.1948 | 56452.3 | 15000000 | 4270000000 | 1290000000000 | 0.4024 | 0.2555 | 0.0004 | 0.0000 | 0.0033 | 0.0002 | 0.0132 | 0.0010 | 0.0356 | 0.0063 | 0.1124 | 0.0290 | 0.1854 | 0.0626 | 0.1649 | 0.0652 | 0.1702 | 0.0924 | 0.3145 | 0.7434 | 0.0000 | 0.0000 | 0.0005 | 0.0000 | 0.0018 | 0.0001 | 0.0102 | 0.0020 | 0.0384 | 0.0138 | 0.0759 | 0.0319 | 0.0663 | 0.0284 | 0.0851 | 0.0426 | 0.7219 | 0.8812 | 0.0023 | 0.0036 | 0.0040 | 0.0136 | 0.0144 | 0.0300 | 0.0586 | 0.0886 | 0.1114 | 0.1671 | 0.1697 | 0.2064 | 0.1117 | 0.1207 | 0.1400 | 0.1486 | 0.3879 | 0.2214 | 0.0012 | 0.0012 | 0.0051 | 0.0274 | 0.0791 | 0.1243 | 0.1042 | 0.1238 | 0.5337 | 8 | 10 | 17 | 42 | 109 | 218 | 349 | 492 | 669 | 0.0408 | 47.90 | 5.810 | 0.3933 | 147362.0 | 116000000 | 111000000000 | 123000000000000 | 0.4697 | 0.1864 | 0.1067 | 0.0030 | 0.2767 | 0.0213 | 0.3109 | 0.2024 | 0.1380 | 0.1983 | 0.0764 | 0.2125 | 0.0525 | 0.1566 | 0.0183 | 0.0876 | 0.0165 | 0.0554 | 0.0040 | 0.0630 | 0.0002 | 0.0001 | 0.0000 | 0.0000 | 0.0009 | 0.0008 | 0.0096 | 0.0068 | 0.0596 | 0.0493 | 0.0934 | 0.0808 | 0.0646 | 0.0569 | 0.0998 | 0.0835 | 0.6719 | 0.7217 | 0.0000 | 0.0001 | 0.0005 | 0.0000 | 0.0016 | 0.0021 | 0.0167 | 0.0199 | 0.0781 | 0.0907 | 0.1165 | 0.1342 | 0.0867 | 0.0938 | 0.1227 | 0.1335 | 0.5771 | 0.5256 | 0.0000 | 0.0001 | 0.0009 | 0.0116 | 0.0678 | 0.1051 | 0.0737 | 0.1126 | 0.6282 | |
MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 1047 | 808 | 11793 | 29672 | 113.4 | 29.34 | 199.72 | 175.90 | 81 | 89 | 96 | 102 | 108 | 115 | 124 | 135 | 153 | 0.0534 | 1583 | 0.454 | 192.20 | 38.59 | 5 | 0.0484 | 571 | 0.0029 | 15.86 | 6.239 | 0.2893 | 13720.4 | 1780000 | 247000000 | 36900000000 | 0.5494 | 0.1414 | 0.0009 | 0.0000 | 0.0048 | 0.0002 | 0.0148 | 0.0015 | 0.0418 | 0.0067 | 0.0987 | 0.0255 | 0.1564 | 0.0610 | 0.1565 | 0.0585 | 0.1823 | 0.0902 | 0.3439 | 0.7563 | 0.0005 | 0.0000 | 0.0016 | 0.0002 | 0.0052 | 0.0007 | 0.0169 | 0.0038 | 0.0447 | 0.0139 | 0.0787 | 0.0369 | 0.0757 | 0.0239 | 0.1044 | 0.0426 | 0.6722 | 0.8779 | 0.0055 | 0.0043 | 0.0115 | 0.0182 | 0.0243 | 0.0503 | 0.0545 | 0.1146 | 0.1261 | 0.1767 | 0.1530 | 0.1734 | 0.1129 | 0.1199 | 0.1500 | 0.1370 | 0.3622 | 0.2056 | 0.0035 | 0.0069 | 0.0125 | 0.0420 | 0.0881 | 0.1219 | 0.1128 | 0.1261 | 0.4861 | 21 | 40 | 70 | 109 | 156 | 208 | 264 | 334 | 444 | 0.0045 | 62.50 | 7.035 | 0.2736 | 70826.1 | 33200000 | 18700000000 | 12000000000000 | 0.4909 | 0.1748 | 0.0241 | 0.0016 | 0.1156 | 0.0080 | 0.2373 | 0.0460 | 0.1905 | 0.1069 | 0.1697 | 0.1785 | 0.1335 | 0.2098 | 0.0719 | 0.1527 | 0.0399 | 0.1470 | 0.0174 | 0.1495 | 0.0004 | 0.0002 | 0.0009 | 0.0011 | 0.0042 | 0.0023 | 0.0126 | 0.0094 | 0.0581 | 0.0468 | 0.1027 | 0.0856 | 0.0862 | 0.0727 | 0.1139 | 0.0958 | 0.6211 | 0.6861 | 0.0010 | 0.0011 | 0.0048 | 0.0062 | 0.0108 | 0.0147 | 0.0306 | 0.0373 | 0.0810 | 0.0966 | 0.1391 | 0.1521 | 0.1107 | 0.1138 | 0.1321 | 0.1356 | 0.4899 | 0.4427 | 0.0002 | 0.0024 | 0.0061 | 0.0189 | 0.0699 | 0.1259 | 0.0994 | 0.1257 | 0.5515 | |
MCF7 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 1074 | 329 | 10716 | 23313 | 347.7 | 91.75 | 73.56 | 114.94 | 242 | 269 | 292 | 314 | 335 | 358 | 384 | 417 | 474 | 0.0592 | 1380 | 0.979 | 123.69 | 46.10 | 1 | 0.0314 | 336 | 0.0009 | 44.10 | 7.309 | 0.1906 | 129299.0 | 51400000 | 21900000000 | 9900000000000 | 0.4246 | 0.2290 | 0.0002 | 0.0000 | 0.0013 | 0.0000 | 0.0081 | 0.0003 | 0.0209 | 0.0023 | 0.0739 | 0.0236 | 0.1547 | 0.0469 | 0.1487 | 0.0470 | 0.1829 | 0.0798 | 0.4092 | 0.8000 | 0.0001 | 0.0000 | 0.0006 | 0.0000 | 0.0026 | 0.0001 | 0.0067 | 0.0011 | 0.0320 | 0.0128 | 0.0693 | 0.0240 | 0.0655 | 0.0222 | 0.0943 | 0.0426 | 0.7287 | 0.8973 | 0.0038 | 0.0033 | 0.0108 | 0.0043 | 0.0169 | 0.0174 | 0.0606 | 0.0587 | 0.0983 | 0.1293 | 0.1396 | 0.1772 | 0.0973 | 0.1283 | 0.1189 | 0.1533 | 0.4537 | 0.3283 | 0.0011 | 0.0027 | 0.0078 | 0.0287 | 0.0782 | 0.1249 | 0.0938 | 0.1276 | 0.5352 | 5 | 6 | 8 | 9 | 13 | 34 | 72 | 133 | 226 | 0.0834 | 10.03 | 3.982 | 0.5196 | 18622.6 | 7300000 | 3800000000 | 2450000000000 | 0.4789 | 0.1814 | 0.0998 | 0.0031 | 0.2338 | 0.0435 | 0.2680 | 0.1682 | 0.1369 | 0.1634 | 0.1119 | 0.1864 | 0.0720 | 0.1590 | 0.0371 | 0.0956 | 0.0306 | 0.0815 | 0.0100 | 0.0993 | 0.0004 | 0.0001 | 0.0003 | 0.0006 | 0.0013 | 0.0018 | 0.0095 | 0.0100 | 0.0610 | 0.0508 | 0.0917 | 0.0745 | 0.0604 | 0.0548 | 0.1046 | 0.0852 | 0.6708 | 0.7222 | 0.0002 | 0.0004 | 0.0018 | 0.0009 | 0.0024 | 0.0034 | 0.0180 | 0.0181 | 0.0720 | 0.0856 | 0.1220 | 0.1315 | 0.0802 | 0.0846 | 0.1175 | 0.1264 | 0.5860 | 0.5492 | 0.0001 | 0.0003 | 0.0026 | 0.0135 | 0.0658 | 0.1063 | 0.0699 | 0.1141 | 0.6274 | |
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 1174 | 311 | 4125 | 7344 | 106.9 | 25.00 | 95.02 | 65.57 | 79 | 86 | 92 | 98 | 103 | 109 | 116 | 125 | 138 | 0.1023 | 751 | 0.955 | 114.81 | 26.63 | 2 | 0.0635 | 262 | 0.0036 | 15.13 | 5.958 | 0.3042 | 12054.8 | 1440000 | 184000000 | 25200000000 | 0.4230 | 0.2295 | 0.0011 | 0.0000 | 0.0026 | 0.0000 | 0.0132 | 0.0000 | 0.0332 | 0.0023 | 0.0716 | 0.0184 | 0.1474 | 0.0522 | 0.1520 | 0.0434 | 0.1840 | 0.0814 | 0.3948 | 0.8023 | 0.0009 | 0.0000 | 0.0015 | 0.0000 | 0.0036 | 0.0000 | 0.0104 | 0.0017 | 0.0361 | 0.0125 | 0.0742 | 0.0330 | 0.0721 | 0.0178 | 0.1028 | 0.0425 | 0.6984 | 0.8924 | 0.0114 | 0.0226 | 0.0142 | 0.0136 | 0.0299 | 0.0452 | 0.0882 | 0.1041 | 0.1437 | 0.2308 | 0.1650 | 0.1719 | 0.1294 | 0.0860 | 0.1479 | 0.1357 | 0.2703 | 0.1900 | 0.0022 | 0.0061 | 0.0116 | 0.0476 | 0.0946 | 0.1489 | 0.1162 | 0.1417 | 0.4311 | 33 | 44 | 55 | 64 | 75 | 90 | 109 | 136 | 188 | 0.0069 | 12.75 | 5.650 | 0.3987 | 13326.8 | 2540000 | 606000000 | 170000000000 | 0.5934 | 0.1414 | 0.0211 | 0.0026 | 0.0695 | 0.0090 | 0.1538 | 0.0214 | 0.1669 | 0.0503 | 0.2066 | 0.1290 | 0.1650 | 0.1834 | 0.1123 | 0.1498 | 0.0707 | 0.1727 | 0.0341 | 0.2817 | 0.0014 | 0.0016 | 0.0049 | 0.0026 | 0.0140 | 0.0038 | 0.0343 | 0.0158 | 0.0954 | 0.0660 | 0.1604 | 0.1257 | 0.1242 | 0.0971 | 0.1310 | 0.1405 | 0.4345 | 0.5469 | 0.0049 | 0.0052 | 0.0152 | 0.0143 | 0.0236 | 0.0448 | 0.0594 | 0.0656 | 0.1233 | 0.1195 | 0.1724 | 0.1961 | 0.1243 | 0.1188 | 0.1464 | 0.1338 | 0.3306 | 0.3019 | 0.0022 | 0.0084 | 0.0205 | 0.0513 | 0.1081 | 0.1729 | 0.1198 | 0.1414 | 0.3755 | |
MDA-MB-231 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 445 | 860 | 2608 | 8307 | 566.5 | 225.38 | 39.43 | 65.37 | 258 | 310 | 392 | 503 | 596 | 677 | 750 | 806 | 842 | 0.0768 | 638 | 0.880 | 77.20 | 20.00 | 3 | 0.0740 | 193 | 0.0009 | 51.94 | 7.257 | 0.1702 | 371659.0 | 266000000 | 199000000000 | 154000000000000 | 0.3620 | 0.2536 | 0.0000 | 0.0000 | 0.0000 | 0.0007 | 0.0062 | 0.0029 | 0.0123 | 0.0065 | 0.1200 | 0.0632 | 0.2369 | 0.1142 | 0.1323 | 0.0639 | 0.1477 | 0.1128 | 0.3446 | 0.6358 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0010 | 0.0012 | 0.0010 | 0.0244 | 0.0282 | 0.0463 | 0.0423 | 0.0220 | 0.0216 | 0.0404 | 0.0423 | 0.8657 | 0.8636 | 0.0000 | 0.0000 | 0.0000 | 0.0017 | 0.0010 | 0.0034 | 0.0077 | 0.0151 | 0.0349 | 0.0689 | 0.0668 | 0.1109 | 0.0445 | 0.0723 | 0.0649 | 0.1008 | 0.7803 | 0.6269 | 0.0000 | 0.0000 | 0.0000 | 0.0021 | 0.0351 | 0.0537 | 0.0387 | 0.0530 | 0.8173 | 7 | 8 | 10 | 12 | 14 | 19 | 25 | 43 | 117 | 0.0947 | 6.43 | 3.634 | 0.6797 | 5827.2 | 1490000 | 484000000 | 182000000000 | 0.3887 | 0.2572 | 0.0457 | 0.0156 | 0.1087 | 0.0288 | 0.1130 | 0.0600 | 0.1478 | 0.1019 | 0.1870 | 0.1397 | 0.1565 | 0.1265 | 0.1326 | 0.1167 | 0.0913 | 0.1553 | 0.0174 | 0.2555 | 0.0059 | 0.0065 | 0.0054 | 0.0126 | 0.0049 | 0.0153 | 0.0178 | 0.0252 | 0.0425 | 0.0520 | 0.0623 | 0.0566 | 0.0440 | 0.0539 | 0.0667 | 0.0768 | 0.7505 | 0.7012 | 0.0019 | 0.0007 | 0.0051 | 0.0021 | 0.0064 | 0.0064 | 0.0230 | 0.0207 | 0.0499 | 0.0486 | 0.0671 | 0.0671 | 0.0486 | 0.0471 | 0.0633 | 0.0643 | 0.7347 | 0.7429 | 0.0011 | 0.0011 | 0.0034 | 0.0190 | 0.0514 | 0.0587 | 0.0509 | 0.0799 | 0.7345 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 836 | 239 | 7959 | 17179 | 111.4 | 30.75 | 133.54 | 119.53 | 79 | 87 | 93 | 99 | 105 | 113 | 122 | 134 | 152 | 0.0646 | 1109 | 0.889 | 111.63 | 30.02 | 1 | 0.0362 | 288 | 0.0014 | 37.17 | 6.950 | 0.2080 | 13344.8 | 1730000 | 244000000 | 37300000000 | 0.4636 | 0.2058 | 0.0004 | 0.0000 | 0.0029 | 0.0004 | 0.0141 | 0.0018 | 0.0306 | 0.0034 | 0.0937 | 0.0251 | 0.1737 | 0.0627 | 0.1673 | 0.0617 | 0.1958 | 0.0914 | 0.3214 | 0.7534 | 0.0002 | 0.0000 | 0.0008 | 0.0003 | 0.0051 | 0.0005 | 0.0142 | 0.0017 | 0.0425 | 0.0148 | 0.0738 | 0.0327 | 0.0751 | 0.0242 | 0.1032 | 0.0422 | 0.6851 | 0.8836 | 0.0013 | 0.0058 | 0.0106 | 0.0101 | 0.0188 | 0.0361 | 0.0625 | 0.1111 | 0.1370 | 0.1789 | 0.1739 | 0.2136 | 0.1169 | 0.0823 | 0.1382 | 0.1270 | 0.3408 | 0.2352 | 0.0021 | 0.0050 | 0.0085 | 0.0349 | 0.0830 | 0.1306 | 0.1065 | 0.1317 | 0.4977 | 15 | 24 | 44 | 68 | 100 | 138 | 175 | 228 | 307 | 0.0163 | 13.12 | 5.549 | 0.4536 | 32119.0 | 10100000 | 3750000000 | 1560000000000 | 0.4503 | 0.2056 | 0.0225 | 0.0016 | 0.0936 | 0.0063 | 0.1855 | 0.0369 | 0.1578 | 0.0822 | 0.1606 | 0.1574 | 0.1341 | 0.1888 | 0.1020 | 0.1438 | 0.0831 | 0.1533 | 0.0606 | 0.2296 | 0.0006 | 0.0006 | 0.0006 | 0.0006 | 0.0026 | 0.0026 | 0.0117 | 0.0095 | 0.0448 | 0.0361 | 0.0845 | 0.0642 | 0.0655 | 0.0513 | 0.0979 | 0.0846 | 0.6919 | 0.7505 | 0.0012 | 0.0017 | 0.0042 | 0.0036 | 0.0080 | 0.0091 | 0.0245 | 0.0282 | 0.0726 | 0.0896 | 0.1213 | 0.1353 | 0.0980 | 0.1046 | 0.1294 | 0.1292 | 0.5407 | 0.4988 | 0.0004 | 0.0006 | 0.0042 | 0.0167 | 0.0586 | 0.0988 | 0.0853 | 0.1203 | 0.6151 | |
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 620 | 230 | 4285 | 3286 | 144.3 | 36.47 | 138.38 | 91.26 | 103 | 114 | 122 | 130 | 138 | 148 | 158 | 173 | 194 | 0.1869 | 614 | 1.042 | 86.49 | 33.29 | 1 | 0.0567 | 243 | 0.0019 | 26.80 | 6.577 | 0.2264 | 22156.9 | 3620000 | 632000000 | 117000000000 | 0.4068 | 0.2461 | 0.0008 | 0.0000 | 0.0024 | 0.0000 | 0.0068 | 0.0008 | 0.0409 | 0.0036 | 0.0895 | 0.0250 | 0.1604 | 0.0595 | 0.1805 | 0.0680 | 0.1781 | 0.0883 | 0.3406 | 0.7550 | 0.0003 | 0.0000 | 0.0015 | 0.0000 | 0.0033 | 0.0007 | 0.0152 | 0.0019 | 0.0396 | 0.0150 | 0.0677 | 0.0307 | 0.0793 | 0.0309 | 0.0999 | 0.0421 | 0.6933 | 0.8786 | 0.0023 | 0.0063 | 0.0058 | 0.0284 | 0.0232 | 0.0473 | 0.0719 | 0.1356 | 0.1241 | 0.1703 | 0.1694 | 0.2177 | 0.1230 | 0.1041 | 0.1381 | 0.1104 | 0.3422 | 0.1798 | 0.0011 | 0.0074 | 0.0079 | 0.0370 | 0.0894 | 0.1174 | 0.1259 | 0.1364 | 0.4775 | 49 | 67 | 82 | 100 | 117 | 136 | 159 | 195 | 252 | 0.0034 | 28.02 | 6.143 | 0.3124 | 27476.4 | 7420000 | 2560000000 | 1060000000000 | 0.5807 | 0.0980 | 0.0129 | 0.0006 | 0.0526 | 0.0104 | 0.1671 | 0.0245 | 0.1542 | 0.0736 | 0.1916 | 0.1373 | 0.1729 | 0.1674 | 0.1320 | 0.1582 | 0.0713 | 0.1398 | 0.0456 | 0.2882 | 0.0006 | 0.0000 | 0.0034 | 0.0030 | 0.0130 | 0.0039 | 0.0419 | 0.0226 | 0.1058 | 0.0826 | 0.1533 | 0.1274 | 0.1250 | 0.1044 | 0.1408 | 0.1261 | 0.4163 | 0.5298 | 0.0066 | 0.0075 | 0.0055 | 0.0105 | 0.0362 | 0.0359 | 0.0768 | 0.0734 | 0.1480 | 0.1722 | 0.1612 | 0.1722 | 0.1261 | 0.1257 | 0.1469 | 0.1437 | 0.2928 | 0.2590 | 0.0023 | 0.0046 | 0.0201 | 0.0610 | 0.1251 | 0.1807 | 0.1127 | 0.1490 | 0.3444 | |
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 906 | 300 | 4616 | 2545 | 127.3 | 33.98 | 169.06 | 144.46 | 93 | 100 | 108 | 114 | 121 | 129 | 137 | 149 | 170 | 0.2303 | 586 | 0.655 | 101.26 | 21.10 | 1 | 0.0570 | 263 | 0.0024 | 23.69 | 6.393 | 0.2429 | 17366.0 | 2560000 | 415000000 | 74600000000 | 0.4222 | 0.2295 | 0.0007 | 0.0000 | 0.0025 | 0.0000 | 0.0079 | 0.0000 | 0.0229 | 0.0026 | 0.0947 | 0.0259 | 0.1804 | 0.0581 | 0.1701 | 0.0504 | 0.1851 | 0.0910 | 0.3358 | 0.7719 | 0.0006 | 0.0000 | 0.0014 | 0.0000 | 0.0030 | 0.0000 | 0.0099 | 0.0013 | 0.0432 | 0.0143 | 0.0842 | 0.0317 | 0.0803 | 0.0229 | 0.1119 | 0.0419 | 0.6656 | 0.8878 | 0.0036 | 0.0107 | 0.0024 | 0.0000 | 0.0358 | 0.0188 | 0.0896 | 0.0965 | 0.1290 | 0.1662 | 0.1673 | 0.2011 | 0.1159 | 0.1421 | 0.1398 | 0.1582 | 0.3166 | 0.2064 | 0.0041 | 0.0041 | 0.0086 | 0.0436 | 0.0933 | 0.1379 | 0.1206 | 0.1409 | 0.4470 | 36 | 55 | 71 | 93 | 121 | 154 | 206 | 274 | 374 | 0.0029 | 65.12 | 6.499 | 0.2709 | 49440.3 | 19800000 | 9460000000 | 5070000000000 | 0.5100 | 0.1410 | 0.0427 | 0.0025 | 0.1467 | 0.0272 | 0.3413 | 0.0938 | 0.1973 | 0.1284 | 0.1040 | 0.2062 | 0.0960 | 0.2185 | 0.0400 | 0.1173 | 0.0240 | 0.1099 | 0.0080 | 0.0963 | 0.0009 | 0.0000 | 0.0061 | 0.0027 | 0.0182 | 0.0089 | 0.0425 | 0.0336 | 0.0981 | 0.0960 | 0.1389 | 0.1289 | 0.1076 | 0.0981 | 0.1250 | 0.1310 | 0.4627 | 0.5007 | 0.0026 | 0.0031 | 0.0064 | 0.0062 | 0.0154 | 0.0278 | 0.0605 | 0.0571 | 0.1107 | 0.1142 | 0.1725 | 0.1821 | 0.1042 | 0.1049 | 0.1184 | 0.1219 | 0.4093 | 0.3827 | 0.0021 | 0.0086 | 0.0182 | 0.0376 | 0.1116 | 0.1642 | 0.0998 | 0.1202 | 0.4378 | |
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 547 | 120 | 5210 | 7031 | 116.5 | 33.51 | 67.29 | 88.49 | 82 | 90 | 96 | 102 | 109 | 116 | 126 | 140 | 161 | 0.1074 | 755 | 0.962 | 86.27 | 33.84 | 2 | 0.0478 | 249 | 0.0029 | 20.97 | 6.262 | 0.2723 | 14702.5 | 2030000 | 306000000 | 50600000000 | 0.4062 | 0.2387 | 0.0018 | 0.0000 | 0.0032 | 0.0000 | 0.0093 | 0.0009 | 0.0370 | 0.0017 | 0.1025 | 0.0273 | 0.1787 | 0.0577 | 0.1630 | 0.0624 | 0.1798 | 0.0955 | 0.3247 | 0.7545 | 0.0010 | 0.0000 | 0.0021 | 0.0000 | 0.0044 | 0.0004 | 0.0154 | 0.0008 | 0.0427 | 0.0160 | 0.0740 | 0.0248 | 0.0717 | 0.0220 | 0.1040 | 0.0419 | 0.6847 | 0.8941 | 0.0019 | 0.0042 | 0.0049 | 0.0166 | 0.0165 | 0.0374 | 0.0525 | 0.0832 | 0.1380 | 0.1933 | 0.1672 | 0.2121 | 0.1263 | 0.0894 | 0.1545 | 0.1538 | 0.3382 | 0.2100 | 0.0039 | 0.0048 | 0.0101 | 0.0400 | 0.0761 | 0.1094 | 0.1104 | 0.1359 | 0.5094 | 12 | 15 | 20 | 26 | 33 | 43 | 64 | 100 | 163 | 0.0295 | 19.01 | 4.722 | 0.5549 | 12357.0 | 4090000 | 1840000000 | 978000000000 | 0.7256 | 0.0616 | 0.0176 | 0.0062 | 0.0821 | 0.0241 | 0.1437 | 0.0469 | 0.1935 | 0.0841 | 0.1686 | 0.1496 | 0.1569 | 0.1695 | 0.0997 | 0.1447 | 0.0982 | 0.1371 | 0.0396 | 0.2378 | 0.0025 | 0.0024 | 0.0050 | 0.0041 | 0.0103 | 0.0111 | 0.0227 | 0.0199 | 0.0900 | 0.0827 | 0.1399 | 0.1253 | 0.0929 | 0.0918 | 0.1312 | 0.1236 | 0.5056 | 0.5392 | 0.0011 | 0.0020 | 0.0092 | 0.0033 | 0.0075 | 0.0139 | 0.0316 | 0.0463 | 0.1086 | 0.1026 | 0.1580 | 0.1794 | 0.1080 | 0.1112 | 0.1356 | 0.1456 | 0.4406 | 0.3958 | 0.0034 | 0.0034 | 0.0112 | 0.0244 | 0.0937 | 0.1541 | 0.0941 | 0.1332 | 0.4824 | |
MCF7 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1040 | 910 | 3585 | 10231 | 344.3 | 84.59 | 34.10 | 76.86 | 243 | 270 | 294 | 317 | 338 | 360 | 384 | 412 | 458 | 0.0777 | 795 | 0.975 | 80.16 | 26.08 | 1 | 0.0555 | 199 | 0.0010 | 48.18 | 7.091 | 0.1715 | 125705.0 | 48500000 | 19700000000 | 8380000000000 | 0.4417 | 0.2214 | 0.0005 | 0.0000 | 0.0029 | 0.0000 | 0.0058 | 0.0006 | 0.0346 | 0.0056 | 0.1029 | 0.0262 | 0.1587 | 0.0586 | 0.1640 | 0.0586 | 0.1722 | 0.0873 | 0.3583 | 0.7630 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0014 | 0.0006 | 0.0122 | 0.0029 | 0.0480 | 0.0161 | 0.0735 | 0.0365 | 0.0724 | 0.0276 | 0.0882 | 0.0419 | 0.7031 | 0.8745 | 0.0056 | 0.0041 | 0.0014 | 0.0331 | 0.0324 | 0.0455 | 0.0606 | 0.0909 | 0.1437 | 0.2066 | 0.1521 | 0.1901 | 0.1211 | 0.1116 | 0.1563 | 0.1570 | 0.3268 | 0.1612 | 0.0006 | 0.0041 | 0.0094 | 0.0241 | 0.0700 | 0.1329 | 0.0988 | 0.1424 | 0.5176 | 5 | 6 | 6 | 8 | 9 | 10 | 14 | 28 | 84 | 0.2835 | 3.77 | 2.562 | 0.7553 | 7069.4 | 2850000 | 1600000000 | 1100000000000 | 0.6411 | 0.0755 | 0.0751 | 0.0073 | 0.1503 | 0.0125 | 0.2306 | 0.0658 | 0.2098 | 0.1524 | 0.1710 | 0.1994 | 0.0984 | 0.1754 | 0.0492 | 0.1242 | 0.0130 | 0.1420 | 0.0026 | 0.1211 | 0.0063 | 0.0020 | 0.0073 | 0.0041 | 0.0078 | 0.0138 | 0.0195 | 0.0292 | 0.0640 | 0.0604 | 0.0762 | 0.0835 | 0.0703 | 0.0722 | 0.0996 | 0.1078 | 0.6489 | 0.6271 | 0.0012 | 0.0040 | 0.0030 | 0.0020 | 0.0084 | 0.0080 | 0.0247 | 0.0172 | 0.0596 | 0.0669 | 0.0915 | 0.0948 | 0.0686 | 0.0749 | 0.1113 | 0.1021 | 0.6318 | 0.6302 | 0.0027 | 0.0027 | 0.0092 | 0.0223 | 0.0566 | 0.0886 | 0.0691 | 0.1033 | 0.6455 |