High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)

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Cell SM Name Small Mol Concentration Small Mol Conc Unit Other Reagent 1 Name Other Reagent 1 Detection Channel Other Reagent 2 Name Other Reagent 2 Detection Channel Row Column Field X-coordinate Y-coordinate Image Nuclear area (pixels) Cytoplasm area (pixels) Nuclear intensity (AU) Std Dev of nuclear intensity (AU) Cytoplasm intensity (AU) Std Dev of cytoplasm intensity (AU) 10% quantile of nuclear intensity (AU) 20% quantile of nuclear intensity (AU) 30% quantile of nuclear intensity (AU) 40% quantile of nuclear intensity (AU) 50% quantile of nuclear intensity (AU) 60% quantile of nuclear intensity (AU) 70% quantile of nuclear intensity (AU) 80% quantile of nuclear intensity (AU) 90% quantile of nuclear intensity (AU) Ratio of cytoplasm perimeter to area Cytoplasm perimeter (pixels) Nuclear roundness Nuclear length (pixels) Nuclear halfwidth (pixels) Number of nuclei Ratio of nuclear perimeter to area Nuclear perimeter (pixels) Nuclear Haralick ASM Nuclear Haralick contrast Nuclear Haralick entropy Nuclear Haralick IDM Nuclear Haralick moment 2 Nuclear Haralick moment 3 Nuclear Haralick moment 4 Nuclear Haralick moment 5 Nuclear radial moment (border) Nuclear radial moment (center) Nuclear Threshold Adj Stat 1 (Threshold: 0.2) Nuclear Threshold Adj Stat 1 (Threshold: 0.4) Nuclear Threshold Adj Stat 2 (Threshold: 0.2) Nuclear Threshold Adj Stat 2 (Threshold: 0.4) Nuclear Threshold Adj Stat 3 (Threshold: 0.2) Nuclear Threshold Adj Stat 3 (Threshold: 0.4) Nuclear Threshold Adj Stat 4 (Threshold: 0.2) Nuclear Threshold Adj Stat 4 (Threshold: 0.4) Nuclear Threshold Adj Stat 5 (Threshold: 0.2) Nuclear Threshold Adj Stat 5 (Threshold: 0.4) Nuclear Threshold Adj Stat 6 (Threshold: 0.2) Nuclear Threshold Adj Stat 6 (Threshold: 0.4) Nuclear Threshold Adj Stat 7 (Threshold: 0.2) Nuclear Threshold Adj Stat 7 (Threshold: 0.4) Nuclear Threshold Adj Stat 8 (Threshold: 0.2) Nuclear Threshold Adj Stat 8 (Threshold: 0.4) Nuclear Threshold Adj Stat 9 (Threshold: 0.2) Nuclear Threshold Adj Stat 9 (Threshold: 0.4) Nuclear Threshold Adj Stat 10 (Threshold: 0.2) Nuclear Threshold Adj Stat 10 (Threshold: 0.4) Nuclear Threshold Adj Stat 11 (Threshold: 0.2) Nuclear Threshold Adj Stat 11 (Threshold: 0.4) Nuclear Threshold Adj Stat 12 (Threshold: 0.2) Nuclear Threshold Adj Stat 12 (Threshold: 0.4) Nuclear Threshold Adj Stat 13 (Threshold: 0.2) Nuclear Threshold Adj Stat 13 (Threshold: 0.4) Nuclear Threshold Adj Stat 14 (Threshold: 0.2) Nuclear Threshold Adj Stat 14 (Threshold: 0.4) Nuclear Threshold Adj Stat 15 (Threshold: 0.2) Nuclear Threshold Adj Stat 15 (Threshold: 0.4) Nuclear Threshold Adj Stat 16 (Threshold: 0.2) Nuclear Threshold Adj Stat 16 (Threshold: 0.4) Nuclear Threshold Adj Stat 17 (Threshold: 0.2) Nuclear Threshold Adj Stat 17 (Threshold: 0.4) Nuclear Threshold Adj Stat 18 (Threshold: 0.2) Nuclear Threshold Adj Stat 18 (Threshold: 0.4) Nuclear Threshold Adj Stat 19 (Threshold: 0.2) Nuclear Threshold Adj Stat 19 (Threshold: 0.4) Nuclear Threshold Adj Stat 20 (Threshold: 0.2) Nuclear Threshold Adj Stat 20 (Threshold: 0.4) Nuclear Threshold Adj Stat 21 (Threshold: 0.2) Nuclear Threshold Adj Stat 21 (Threshold: 0.4) Nuclear Threshold Adj Stat 22 (Threshold: 0.2) Nuclear Threshold Adj Stat 22 (Threshold: 0.4) Nuclear Threshold Adj Stat 23 (Threshold: 0.2) Nuclear Threshold Adj Stat 23 (Threshold: 0.4) Nuclear Threshold Adj Stat 24 (Threshold: 0.2) Nuclear Threshold Adj Stat 24 (Threshold: 0.4) Nuclear Threshold Adj Stat 25 (Threshold: 0.2) Nuclear Threshold Adj Stat 25 (Threshold: 0.4) Nuclear Threshold Adj Stat 26 (Threshold: 0.2) Nuclear Threshold Adj Stat 26 (Threshold: 0.4) Nuclear Threshold Adj Stat 27 (Threshold: 0.2) Nuclear Threshold Adj Stat 27 (Threshold: 0.4) Nuclear Threshold Adj Stat 28 Nuclear Threshold Adj Stat 29 Nuclear Threshold Adj Stat 30 Nuclear Threshold Adj Stat 31 Nuclear Threshold Adj Stat 32 Nuclear Threshold Adj Stat 33 Nuclear Threshold Adj Stat 34 Nuclear Threshold Adj Stat 35 Nuclear Threshold Adj Stat 36 10% quantile of cytoplasm intensity (AU) 20% quantile of cytoplasm intensity (AU) 30% quantile of cytoplasm intensity (AU) 40% quantile of cytoplasm intensity (AU) 50% quantile of cytoplasm intensity (AU) 60% quantile of cytoplasm intensity (AU) 70% quantile of cytoplasm intensity (AU) 80% quantile of cytoplasm intensity (AU) 90% quantile of cytoplasm intensity (AU) Cytoplasmic Haralick ASM Cytoplasmic Haralick contrast Cytoplasmic Haralick entropy Cytoplasmic Haralick IDM Cytoplasmic Haralick moment 2 Cytoplasmic Haralick moment 3 Cytoplasmic Haralick moment 4 Cytoplasmic Haralick moment 5 Cytoplasmic radial moment (border) Cytoplasmic radial moment (center) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 28 Cytoplasmic Threshold Adj Stat 29 Cytoplasmic Threshold Adj Stat 30 Cytoplasmic Threshold Adj Stat 31 Cytoplasmic Threshold Adj Stat 32 Cytoplasmic Threshold Adj Stat 33 Cytoplasmic Threshold Adj Stat 34 Cytoplasmic Threshold Adj Stat 35 Cytoplasmic Threshold Adj Stat 36
MCF7 A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 902 439 image if available 9462 17615 66.2 18.80 11.63 7.94 45 48 51 57 63 69 76 85 93 0.0582 1025 0.806 93.06 26.68 0 0.0260 246 0.0396 0.80 3.627 0.7208 4738.0
364637
29900000
2590000000
0.4090 0.2322 0.0114 0.0009 0.0137 0.0014 0.0190 0.0032 0.0307 0.0089 0.0497 0.0193 0.0678 0.0417 0.0898 0.0415 0.1269 0.0742 0.5909 0.8088 0.0052 0.0000 0.0064 0.0002 0.0081 0.0003 0.0109 0.0024 0.0165 0.0081 0.0215 0.0205 0.0284 0.0132 0.0370 0.0319 0.8659 0.9234 0.0061 0.0140 0.0065 0.0220 0.0105 0.0451 0.0252 0.0762 0.0304 0.1062 0.0527 0.1333 0.0641 0.1283 0.0933 0.1413 0.7112 0.3337 0.0026 0.0049 0.0086 0.0123 0.0283 0.0339 0.0416 0.0706 0.7972 5 6 7 8 9 10 12 15 22 0.2867 0.33 1.922 0.8442 198.3
4862.52
154893
5820000
0.5138 0.1400 0.0871 0.0128 0.1401 0.0280 0.1505 0.0586 0.1491 0.0912 0.1521 0.1375 0.1294 0.1665 0.1167 0.1770 0.0606 0.1781 0.0146 0.1503 0.0408 0.0059 0.0668 0.0174 0.0671 0.0381 0.0575 0.0614 0.0582 0.0937 0.0540 0.1156 0.0645 0.1142 0.0925 0.1136 0.4986 0.4402 0.0246 0.0157 0.0222 0.0242 0.0309 0.0310 0.0415 0.0336 0.0492 0.0529 0.0632 0.0663 0.0719 0.0777 0.1169 0.1326 0.5796 0.5660 0.0564 0.0389 0.0353 0.0306 0.0484 0.0603 0.0728 0.0984 0.5589
MDA-MB-231 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 708 397 image if available 15447 27394 562.4 113.78 118.30 212.73 394 458 507 542 576 606 636 667 703 0.0495 1356 0.896 108.19 30.00 3 0.0188 291 0.0006 29.72 7.605 0.2191 329218.0
199000000
124000000000
78600000000000
0.3988 0.2308 0.0014 0.0000 0.0019 0.0001 0.0040 0.0004 0.0105 0.0011 0.0269 0.0087 0.0473 0.0169 0.0485 0.0102 0.0672 0.0157 0.7922 0.9469 0.0001 0.0000 0.0002 0.0000 0.0005 0.0001 0.0023 0.0010 0.0107 0.0080 0.0188 0.0166 0.0160 0.0091 0.0204 0.0143 0.9310 0.9510 0.0029 0.0000 0.0095 0.0179 0.0147 0.0536 0.0297 0.1607 0.0612 0.1250 0.0718 0.1071 0.0872 0.2500 0.1213 0.1071 0.6015 0.1786 0.0008 0.0010 0.0032 0.0069 0.0226 0.0401 0.0411 0.0534 0.8309 7 9 10 11 12 15 40 206 467 0.3132 20.18 3.462 0.7115 59247.2
38200000
27600000000
21600000000000
0.5023 0.1444 0.0436 0.0036 0.1336 0.0128 0.2377 0.1026 0.1744 0.1354 0.1547 0.1810 0.1069 0.1882 0.0675 0.1055 0.0520 0.1119 0.0295 0.1589 0.0000 0.0003 0.0003 0.0004 0.0010 0.0004 0.0058 0.0038 0.0203 0.0189 0.0418 0.0353 0.0301 0.0220 0.0517 0.0418 0.8491 0.8771 0.0000 0.0000 0.0006 0.0005 0.0003 0.0005 0.0058 0.0079 0.0263 0.0302 0.0558 0.0631 0.0452 0.0492 0.0622 0.0705 0.8037 0.7782 0.0000 0.0000 0.0006 0.0049 0.0263 0.0486 0.0405 0.0571 0.8221
BT-20 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 472 365 image if available 10152 16333 306.6 57.54 224.30 196.37 237 256 271 285 301 317 336 357 386 0.0678 1107 0.822 136.62 44.05 1 0.0396 402 0.0006 77.66 7.651 0.1416 97320.9
31900000
10800000000
3780000000000
0.4559 0.2016 0.0007 0.0000 0.0006 0.0000 0.0038 0.0001 0.0147 0.0006 0.0559 0.0105 0.1218 0.0272 0.1337 0.0260 0.1584 0.0428 0.5103 0.8928 0.0002 0.0000 0.0000 0.0000 0.0011 0.0000 0.0036 0.0001 0.0257 0.0079 0.0578 0.0184 0.0582 0.0109 0.0841 0.0197 0.7693 0.9430 0.0025 0.0159 0.0101 0.0518 0.0297 0.0876 0.0802 0.2072 0.1723 0.1952 0.1799 0.1474 0.1187 0.1036 0.1503 0.0558 0.2563 0.1355 0.0008 0.0025 0.0127 0.0317 0.0909 0.1254 0.1094 0.1379 0.4885 22 46 83 125 173 229 295 376 500 0.0068 69.26 6.886 0.2834 88869.9
46400000
29000000000
20500000000000
0.5451 0.1262 0.0275 0.0020 0.1405 0.0066 0.2540 0.0553 0.1753 0.1106 0.1531 0.1890 0.1086 0.2034 0.0715 0.1379 0.0376 0.1361 0.0319 0.1591 0.0004 0.0006 0.0004 0.0007 0.0035 0.0023 0.0163 0.0094 0.0680 0.0540 0.1119 0.0867 0.0864 0.0698 0.1192 0.1056 0.5940 0.6708 0.0002 0.0013 0.0020 0.0036 0.0087 0.0107 0.0296 0.0330 0.1018 0.1162 0.1498 0.1759 0.1073 0.1119 0.1433 0.1478 0.4572 0.3996 0.0004 0.0016 0.0045 0.0181 0.0879 0.1310 0.0994 0.1385 0.5186
MCF7 A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 1123 700 image if available 12030 35050 359.5 76.99 172.29 212.34 266 289 311 331 350 372 398 428 469 0.0370 1298 1.080 120.07 37.70 1 0.0246 296 0.0007 42.37 7.437 0.1770 135186.0
53100000
21700000000
9200000000000
0.4257 0.2254 0.0007 0.0000 0.0024 0.0001 0.0047 0.0001 0.0166 0.0019 0.0578 0.0130 0.1117 0.0286 0.1278 0.0293 0.1729 0.0489 0.5054 0.8782 0.0001 0.0000 0.0007 0.0000 0.0021 0.0000 0.0074 0.0004 0.0263 0.0079 0.0509 0.0166 0.0541 0.0114 0.0771 0.0203 0.7814 0.9434 0.0031 0.0144 0.0096 0.0431 0.0206 0.0431 0.0477 0.1150 0.0984 0.1889 0.1164 0.1725 0.1067 0.1376 0.1474 0.1212 0.4501 0.1643 0.0022 0.0027 0.0087 0.0265 0.0634 0.0961 0.0890 0.1053 0.6061 8 10 16 35 74 134 219 336 490 0.0515 30.59 5.525 0.4509 74768.6
43400000
30000000000
23500000000000
0.4088 0.2228 0.0812 0.0029 0.2274 0.0275 0.2491 0.1801 0.1201 0.1627 0.1228 0.1764 0.0750 0.1525 0.0533 0.1018 0.0392 0.0801 0.0320 0.1161 0.0001 0.0001 0.0002 0.0004 0.0010 0.0009 0.0095 0.0074 0.0610 0.0504 0.1018 0.0884 0.0671 0.0617 0.1083 0.0895 0.6509 0.7012 0.0002 0.0002 0.0005 0.0005 0.0022 0.0037 0.0162 0.0203 0.0769 0.0888 0.1277 0.1338 0.0832 0.0898 0.1251 0.1318 0.5682 0.5312 0.0003 0.0002 0.0015 0.0144 0.0678 0.1109 0.0804 0.1157 0.6087
MDA-MB-231 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 200 513 image if available 11296 11224 660.4 94.02 95.02 136.71 543 587 617 640 661 683 708 735 774 0.1009 1133 0.918 133.74 44.91 2 0.0313 353 0.0006 79.90 7.739 0.1635 444990.0
305000000
213000000000
152000000000000
0.4251 0.2228 0.0000 0.0000 0.0005 0.0000 0.0017 0.0000 0.0042 0.0006 0.0187 0.0081 0.0399 0.0182 0.0436 0.0113 0.0656 0.0181 0.8257 0.9436 0.0000 0.0000 0.0002 0.0000 0.0006 0.0000 0.0022 0.0004 0.0107 0.0077 0.0240 0.0167 0.0219 0.0084 0.0314 0.0139 0.9090 0.9530 0.0074 0.0816 0.0173 0.0204 0.0222 0.0408 0.0937 0.2245 0.0912 0.2245 0.1307 0.2041 0.1097 0.0816 0.1233 0.1224 0.4044 0.0000 0.0016 0.0026 0.0092 0.0209 0.0527 0.0772 0.0800 0.1071 0.6486 12 16 20 27 38 53 81 138 272 0.0564 8.94 4.344 0.6275 27717.6
13300000
8080000000
5720000000000
0.4886 0.1747 0.0110 0.0020 0.0386 0.0109 0.0684 0.0288 0.1323 0.0387 0.2183 0.1107 0.1940 0.1846 0.1147 0.1166 0.1422 0.1509 0.0805 0.3568 0.0009 0.0007 0.0031 0.0037 0.0037 0.0072 0.0119 0.0120 0.0417 0.0400 0.0716 0.0744 0.0409 0.0423 0.0707 0.0596 0.7555 0.7601 0.0008 0.0004 0.0011 0.0022 0.0042 0.0043 0.0168 0.0173 0.0348 0.0381 0.0880 0.0934 0.0513 0.0510 0.0677 0.0636 0.7353 0.7297 0.0007 0.0010 0.0036 0.0116 0.0416 0.0819 0.0459 0.0714 0.7423
MCF7 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 828 486 image if available 14994 31048 470.7 84.93 145.23 202.56 364 398 424 447 469 490 513 542 583 0.0407 1265 1.143 89.20 33.84 2 0.0156 234 0.0008 39.09 7.354 0.1815 228773.0
115000000
59000000000
31200000000000
0.4389 0.2085 0.0001 0.0000 0.0001 0.0000 0.0020 0.0001 0.0111 0.0005 0.0411 0.0092 0.0890 0.0204 0.0990 0.0211 0.1268 0.0342 0.6308 0.9146 0.0000 0.0000 0.0000 0.0000 0.0008 0.0001 0.0049 0.0001 0.0183 0.0077 0.0417 0.0152 0.0417 0.0114 0.0544 0.0195 0.8381 0.9459 0.0048 0.0278 0.0077 0.0556 0.0191 0.1065 0.0689 0.1991 0.1411 0.2083 0.1689 0.1435 0.1325 0.0694 0.1536 0.1019 0.3033 0.0880 0.0004 0.0009 0.0068 0.0261 0.0682 0.1054 0.0961 0.1216 0.5745 6 8 10 13 30 83 171 296 457 0.1239 27.73 4.902 0.5414 62118.6
35000000
22900000000
16700000000000
0.4409 0.1994 0.0472 0.0018 0.1760 0.0086 0.2720 0.1069 0.1840 0.1494 0.1220 0.1901 0.0838 0.2070 0.0520 0.1123 0.0355 0.0968 0.0276 0.1271 0.0004 0.0000 0.0002 0.0003 0.0004 0.0005 0.0104 0.0070 0.0419 0.0383 0.0677 0.0587 0.0504 0.0418 0.0695 0.0619 0.7590 0.7915 0.0002 0.0002 0.0013 0.0006 0.0008 0.0007 0.0105 0.0168 0.0580 0.0609 0.0871 0.0932 0.0560 0.0646 0.0902 0.0922 0.6960 0.6707 0.0000 0.0003 0.0015 0.0114 0.0475 0.0781 0.0516 0.0805 0.7292
MDA-MB-231 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 305 753 image if available 14531 31502 446.4 61.03 117.13 162.48 365 402 424 439 452 464 476 491 515 0.0488 1538 0.844 110.02 27.80 4 0.0189 274 0.0017 18.96 6.823 0.2707 202963.0
93800000
44000000000
21000000000000
0.4307 0.2135 0.0003 0.0001 0.0001 0.0000 0.0009 0.0000 0.0036 0.0001 0.0149 0.0077 0.0284 0.0166 0.0253 0.0080 0.0383 0.0128 0.8882 0.9547 0.0001 0.0001 0.0000 0.0000 0.0000 0.0000 0.0019 0.0001 0.0098 0.0077 0.0186 0.0166 0.0149 0.0080 0.0188 0.0117 0.9360 0.9558 0.0148 1.0000 0.0239 0.0000 0.0091 0.0000 0.0262 0.0000 0.0809 0.0000 0.0945 0.0000 0.0809 0.0000 0.1173 0.0000 0.5524 0.0000 0.0022 0.0070 0.0123 0.0187 0.0346 0.0523 0.0642 0.0921 0.7167 13 16 21 33 52 79 118 180 305 0.0400 19.55 4.937 0.5597 40119.5
22800000
16800000000
14600000000000
0.4801 0.1897 0.0180 0.0019 0.0684 0.0102 0.1417 0.0304 0.1389 0.0605 0.1660 0.1385 0.1648 0.1775 0.1107 0.1263 0.1041 0.1394 0.0873 0.3154 0.0012 0.0003 0.0022 0.0020 0.0034 0.0030 0.0115 0.0124 0.0463 0.0387 0.0745 0.0614 0.0495 0.0472 0.0766 0.0656 0.7348 0.7694 0.0005 0.0007 0.0024 0.0020 0.0066 0.0068 0.0187 0.0217 0.0585 0.0622 0.0953 0.1084 0.0633 0.0699 0.0954 0.0979 0.6595 0.6304 0.0004 0.0017 0.0044 0.0151 0.0498 0.0888 0.0599 0.0831 0.6968
Hs 578T Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 709 307 image if available 13145 33263 215.6 52.79 151.28 220.31 149 174 189 203 216 228 242 259 283 0.0407 1355 1.265 23.41 8.25 1 0.0043 57 0.0010 34.06 7.246 0.2053 49257.3
11800000
2960000000
769000000000
0.3831 0.2579 0.0004 0.0000 0.0020 0.0000 0.0040 0.0005 0.0168 0.0025 0.0464 0.0130 0.0932 0.0319 0.1084 0.0316 0.1447 0.0480 0.5842 0.8725 0.0000 0.0000 0.0004 0.0000 0.0014 0.0001 0.0053 0.0012 0.0169 0.0077 0.0331 0.0189 0.0378 0.0116 0.0514 0.0186 0.8537 0.9419 0.0054 0.0148 0.0050 0.0411 0.0204 0.0542 0.0549 0.1117 0.0976 0.1215 0.1187 0.1560 0.1145 0.1034 0.1287 0.1051 0.4549 0.2923 0.0014 0.0017 0.0065 0.0214 0.0510 0.0797 0.0892 0.1055 0.6436 12 15 20 31 50 92 148 246 442 0.0346 37.24 5.501 0.4820 71418.1
52500000
49100000000
54400000000000
0.4267 0.2463 0.0312 0.0012 0.1250 0.0165 0.2039 0.0728 0.1419 0.0958 0.1495 0.1578 0.1419 0.1887 0.0914 0.1192 0.0623 0.1242 0.0530 0.2238 0.0005 0.0003 0.0020 0.0009 0.0057 0.0031 0.0160 0.0110 0.0513 0.0476 0.0861 0.0794 0.0620 0.0504 0.0781 0.0712 0.6982 0.7362 0.0005 0.0004 0.0014 0.0037 0.0064 0.0063 0.0183 0.0174 0.0625 0.0699 0.1084 0.1182 0.0749 0.0836 0.1034 0.1020 0.6243 0.5984 0.0008 0.0015 0.0050 0.0158 0.0576 0.0968 0.0701 0.0894 0.6629
BT-20 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 1097 888 image if available 12238 26075 289.7 37.50 189.36 227.04 244 259 270 279 288 297 306 319 339 0.0439 1145 0.830 88.09 22.20 1 0.0187 229 0.0028 13.76 6.262 0.2992 85311.3
25500000
7770000000
2410000000000
0.4323 0.2203 0.0001 0.0000 0.0006 0.0000 0.0020 0.0000 0.0060 0.0003 0.0185 0.0078 0.0396 0.0156 0.0439 0.0098 0.0748 0.0169 0.8146 0.9496 0.0000 0.0000 0.0001 0.0000 0.0004 0.0000 0.0019 0.0001 0.0111 0.0076 0.0227 0.0147 0.0220 0.0071 0.0372 0.0112 0.9046 0.9593 0.0133 0.0000 0.0200 0.0000 0.0333 0.0000 0.0765 0.0000 0.1109 0.0000 0.1408 0.0000 0.1264 0.0000 0.1574 0.0000 0.3215 0.0000 0.0025 0.0088 0.0142 0.0239 0.0616 0.0902 0.0999 0.1291 0.5696 14 17 21 38 82 149 243 368 535 0.0346 41.52 5.730 0.4531 87402.9
53700000
38800000000
31400000000000
0.4360 0.2156 0.0618 0.0023 0.2087 0.0236 0.2420 0.1370 0.1346 0.1541 0.1098 0.1754 0.0927 0.1578 0.0590 0.0979 0.0495 0.0906 0.0418 0.1614 0.0001 0.0003 0.0003 0.0006 0.0015 0.0013 0.0103 0.0092 0.0495 0.0407 0.0808 0.0715 0.0648 0.0501 0.0944 0.0787 0.6983 0.7478 0.0000 0.0003 0.0007 0.0015 0.0026 0.0033 0.0159 0.0223 0.0664 0.0710 0.1136 0.1319 0.0845 0.0978 0.1225 0.1311 0.5939 0.5409 0.0004 0.0007 0.0021 0.0134 0.0562 0.0948 0.0755 0.1060 0.6510
SK-BR-3 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 518 503 image if available 15648 56021 320.9 59.50 142.33 181.99 244 279 299 315 329 341 354 368 389 0.0239 1341 0.987 126.85 36.01 1 0.0202 316 0.0015 21.65 6.855 0.2488 106538.0
36300000
12600000000
4480000000000
0.4413 0.2040 0.0005 0.0000 0.0005 0.0000 0.0020 0.0000 0.0079 0.0003 0.0295 0.0078 0.0562 0.0157 0.0615 0.0104 0.0915 0.0162 0.7503 0.9496 0.0000 0.0000 0.0000 0.0000 0.0002 0.0000 0.0023 0.0003 0.0109 0.0075 0.0242 0.0143 0.0210 0.0081 0.0316 0.0119 0.9098 0.9580 0.0090 0.0536 0.0157 0.0179 0.0336 0.1429 0.0745 0.2143 0.1272 0.1429 0.1557 0.1607 0.1429 0.1071 0.1597 0.0357 0.2818 0.1250 0.0008 0.0025 0.0050 0.0158 0.0410 0.0684 0.0815 0.0977 0.6873 8 10 12 18 51 108 178 269 424 0.1076 16.66 4.969 0.5393 53375.8
26600000
15300000000
9680000000000
0.3694 0.2725 0.0166 0.0013 0.1012 0.0060 0.2168 0.0361 0.1910 0.0912 0.1770 0.1724 0.1403 0.2115 0.0824 0.1547 0.0457 0.1475 0.0291 0.1792 0.0006 0.0002 0.0006 0.0006 0.0027 0.0015 0.0085 0.0065 0.0354 0.0299 0.0682 0.0565 0.0555 0.0459 0.0719 0.0641 0.7567 0.7947 0.0005 0.0005 0.0022 0.0022 0.0040 0.0048 0.0126 0.0154 0.0463 0.0551 0.0837 0.0934 0.0695 0.0743 0.0862 0.0911 0.6950 0.6633 0.0005 0.0017 0.0041 0.0114 0.0416 0.0737 0.0613 0.0797 0.7260
Hs 578T
0
DRAQ5 1 TMRE 2 2 2 1 987 380 image if available 12791 25828 244.0 56.67 95.18 198.31 177 201 217 230 243 256 271 289 316 0.0428 1106 0.611 50.00 6.08 2 0.0081 104 0.0009 41.29 7.385 0.1837 62748.8
16900000
4720000000
1370000000000
0.4150 0.2225 0.0007 0.0000 0.0010 0.0000 0.0040 0.0001 0.0139 0.0020 0.0437 0.0128 0.0935 0.0267 0.1037 0.0271 0.1485 0.0436 0.5911 0.8877 0.0004 0.0000 0.0005 0.0000 0.0012 0.0000 0.0051 0.0007 0.0167 0.0075 0.0370 0.0142 0.0370 0.0105 0.0578 0.0186 0.8443 0.9484 0.0051 0.0074 0.0136 0.0297 0.0230 0.0408 0.0519 0.1169 0.0928 0.1447 0.1328 0.1855 0.0992 0.1039 0.1507 0.1169 0.4308 0.2542 0.0013 0.0041 0.0084 0.0209 0.0523 0.0900 0.0917 0.1156 0.6157 10 11 13 16 19 30 61 128 252 0.1445 34.06 4.024 0.6355 48384.8
50100000
70500000000
115000000000000
0.4211 0.2561 0.0753 0.0013 0.2507 0.0276 0.3011 0.1619 0.1172 0.1639 0.1051 0.2101 0.0717 0.1905 0.0362 0.0921 0.0291 0.0768 0.0135 0.0758 0.0001 0.0002 0.0003 0.0001 0.0021 0.0012 0.0147 0.0116 0.0679 0.0616 0.1162 0.1005 0.0657 0.0596 0.1024 0.0930 0.6306 0.6721 0.0002 0.0012 0.0012 0.0028 0.0041 0.0058 0.0225 0.0271 0.0797 0.0776 0.1234 0.1387 0.0808 0.0856 0.1154 0.1264 0.5727 0.5349 0.0002 0.0013 0.0034 0.0168 0.0750 0.1186 0.0738 0.1066 0.6045
Hs 578T A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 800 501 image if available 13792 38751 266.6 61.19 169.99 277.73 192 219 237 253 267 281 297 317 345 0.0391 1515 0.913 98.60 27.17 6 0.0188 259 0.0012 28.43 7.043 0.2221 74836.6
21900000
6660000000
2090000000000
0.4163 0.2227 0.0000 0.0000 0.0013 0.0000 0.0034 0.0004 0.0145 0.0030 0.0508 0.0123 0.1000 0.0294 0.1083 0.0291 0.1428 0.0414 0.5789 0.8845 0.0000 0.0000 0.0006 0.0000 0.0009 0.0002 0.0051 0.0012 0.0181 0.0073 0.0381 0.0171 0.0415 0.0105 0.0570 0.0160 0.8387 0.9478 0.0032 0.0074 0.0083 0.0315 0.0221 0.0612 0.0437 0.1169 0.1095 0.1818 0.1536 0.1892 0.1312 0.1373 0.1276 0.1150 0.4009 0.1596 0.0001 0.0023 0.0069 0.0225 0.0520 0.0995 0.0920 0.1141 0.6107 11 14 16 21 32 62 139 285 553 0.1524 25.56 4.437 0.6078 106029.0
97600000
110000000000
141000000000000
0.3354 0.3305 0.0662 0.0027 0.2254 0.0240 0.2667 0.1419 0.1607 0.1818 0.1295 0.1818 0.0830 0.1829 0.0379 0.1071 0.0230 0.0916 0.0077 0.0861 0.0003 0.0003 0.0010 0.0006 0.0035 0.0021 0.0193 0.0153 0.0582 0.0549 0.0728 0.0726 0.0478 0.0442 0.0766 0.0719 0.7205 0.7381 0.0006 0.0007 0.0019 0.0018 0.0059 0.0059 0.0221 0.0258 0.0548 0.0602 0.0841 0.0861 0.0579 0.0644 0.0867 0.0924 0.6859 0.6628 0.0003 0.0015 0.0047 0.0221 0.0559 0.0766 0.0542 0.0790 0.7058
BT-20 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 923 749 image if available 18485 19144 337.4 48.91 148.53 162.19 268 300 318 331 344 355 367 380 396 0.0705 1349 1.142 100.72 39.20 2 0.0147 271 0.0025 9.90 6.327 0.3429 116234.0
40800000
14500000000
5230000000000
0.4218 0.2181 0.0005 0.0000 0.0012 0.0001 0.0027 0.0001 0.0083 0.0008 0.0174 0.0071 0.0285 0.0145 0.0316 0.0074 0.0551 0.0119 0.8546 0.9581 0.0001 0.0000 0.0000 0.0001 0.0005 0.0001 0.0022 0.0008 0.0085 0.0071 0.0136 0.0145 0.0122 0.0074 0.0186 0.0119 0.9443 0.9581 0.0326 0.0000 0.0692 0.0000 0.0794 0.0000 0.1090 0.0000 0.1517 0.0000 0.1415 0.0000 0.1395 0.0000 0.1446 0.0000 0.1324 0.0000 0.0028 0.0050 0.0091 0.0138 0.0293 0.0412 0.0457 0.0737 0.7793 23 31 42 57 77 109 167 256 387 0.0183 13.36 5.441 0.5104 48364.8
22700000
12800000000
8140000000000
0.3890 0.2609 0.0233 0.0013 0.0952 0.0085 0.1700 0.0530 0.1578 0.1011 0.1966 0.1512 0.1445 0.1702 0.0908 0.1386 0.0714 0.1404 0.0504 0.2358 0.0001 0.0003 0.0008 0.0009 0.0026 0.0044 0.0128 0.0124 0.0492 0.0417 0.0708 0.0661 0.0547 0.0448 0.0827 0.0706 0.7262 0.7587 0.0007 0.0006 0.0009 0.0017 0.0035 0.0058 0.0196 0.0235 0.0581 0.0707 0.0989 0.0946 0.0629 0.0773 0.0941 0.1006 0.6612 0.6252 0.0000 0.0010 0.0043 0.0159 0.0522 0.0864 0.0570 0.0870 0.6963
SK-BR-3 A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 969 728 image if available 16378 49009 195.5 37.68 203.96 331.62 151 169 180 189 198 206 215 226 241 0.0278 1362 1.188 93.09 34.48 1 0.0143 235 0.0032 12.80 6.161 0.3225 39638.5
8270000
1770000000
387000000000
0.4222 0.2262 0.0002 0.0000 0.0012 0.0000 0.0037 0.0000 0.0129 0.0003 0.0346 0.0080 0.0661 0.0181 0.0824 0.0160 0.1152 0.0268 0.6836 0.9309 0.0001 0.0000 0.0003 0.0000 0.0008 0.0000 0.0036 0.0001 0.0120 0.0068 0.0260 0.0139 0.0283 0.0069 0.0418 0.0107 0.8870 0.9616 0.0089 0.0576 0.0166 0.0995 0.0426 0.1047 0.0736 0.1780 0.1192 0.1937 0.1473 0.1675 0.1256 0.0733 0.1456 0.0890 0.3206 0.0366 0.0012 0.0027 0.0072 0.0202 0.0501 0.0834 0.0821 0.1197 0.6333 7 8 10 12 17 54 192 390 701 0.1432 35.53 4.788 0.5519 151568.0
149000000
169000000000
211000000000000
0.4292 0.2197 0.0529 0.0035 0.2034 0.0131 0.2775 0.1127 0.1544 0.1604 0.1262 0.2014 0.0909 0.1979 0.0516 0.1081 0.0322 0.1003 0.0110 0.1027 0.0001 0.0001 0.0003 0.0001 0.0010 0.0003 0.0081 0.0057 0.0395 0.0371 0.0691 0.0641 0.0487 0.0414 0.0700 0.0648 0.7633 0.7864 0.0004 0.0003 0.0011 0.0011 0.0028 0.0036 0.0129 0.0138 0.0452 0.0466 0.0753 0.0825 0.0565 0.0561 0.0729 0.0789 0.7329 0.7170 0.0001 0.0013 0.0022 0.0102 0.0423 0.0730 0.0512 0.0723 0.7473