High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)

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Cell SM Name Small Mol Concentration Small Mol Conc Unit Other Reagent 1 Name Other Reagent 1 Detection Channel Other Reagent 2 Name Other Reagent 2 Detection Channel Row Column Field X-coordinate Y-coordinate Image Nuclear area (pixels) Cytoplasm area (pixels) Nuclear intensity (AU) Std Dev of nuclear intensity (AU) Cytoplasm intensity (AU) Std Dev of cytoplasm intensity (AU) 10% quantile of nuclear intensity (AU) 20% quantile of nuclear intensity (AU) 30% quantile of nuclear intensity (AU) 40% quantile of nuclear intensity (AU) 50% quantile of nuclear intensity (AU) 60% quantile of nuclear intensity (AU) 70% quantile of nuclear intensity (AU) 80% quantile of nuclear intensity (AU) 90% quantile of nuclear intensity (AU) Ratio of cytoplasm perimeter to area Cytoplasm perimeter (pixels) Nuclear roundness Nuclear length (pixels) Nuclear halfwidth (pixels) Number of nuclei Ratio of nuclear perimeter to area Nuclear perimeter (pixels) Nuclear Haralick ASM Nuclear Haralick contrast Nuclear Haralick entropy Nuclear Haralick IDM Nuclear Haralick moment 2 Nuclear Haralick moment 3 Nuclear Haralick moment 4 Nuclear Haralick moment 5 Nuclear radial moment (border) Nuclear radial moment (center) Nuclear Threshold Adj Stat 1 (Threshold: 0.2) Nuclear Threshold Adj Stat 1 (Threshold: 0.4) Nuclear Threshold Adj Stat 2 (Threshold: 0.2) Nuclear Threshold Adj Stat 2 (Threshold: 0.4) Nuclear Threshold Adj Stat 3 (Threshold: 0.2) Nuclear Threshold Adj Stat 3 (Threshold: 0.4) Nuclear Threshold Adj Stat 4 (Threshold: 0.2) Nuclear Threshold Adj Stat 4 (Threshold: 0.4) Nuclear Threshold Adj Stat 5 (Threshold: 0.2) Nuclear Threshold Adj Stat 5 (Threshold: 0.4) Nuclear Threshold Adj Stat 6 (Threshold: 0.2) Nuclear Threshold Adj Stat 6 (Threshold: 0.4) Nuclear Threshold Adj Stat 7 (Threshold: 0.2) Nuclear Threshold Adj Stat 7 (Threshold: 0.4) Nuclear Threshold Adj Stat 8 (Threshold: 0.2) Nuclear Threshold Adj Stat 8 (Threshold: 0.4) Nuclear Threshold Adj Stat 9 (Threshold: 0.2) Nuclear Threshold Adj Stat 9 (Threshold: 0.4) Nuclear Threshold Adj Stat 10 (Threshold: 0.2) Nuclear Threshold Adj Stat 10 (Threshold: 0.4) Nuclear Threshold Adj Stat 11 (Threshold: 0.2) Nuclear Threshold Adj Stat 11 (Threshold: 0.4) Nuclear Threshold Adj Stat 12 (Threshold: 0.2) Nuclear Threshold Adj Stat 12 (Threshold: 0.4) Nuclear Threshold Adj Stat 13 (Threshold: 0.2) Nuclear Threshold Adj Stat 13 (Threshold: 0.4) Nuclear Threshold Adj Stat 14 (Threshold: 0.2) Nuclear Threshold Adj Stat 14 (Threshold: 0.4) Nuclear Threshold Adj Stat 15 (Threshold: 0.2) Nuclear Threshold Adj Stat 15 (Threshold: 0.4) Nuclear Threshold Adj Stat 16 (Threshold: 0.2) Nuclear Threshold Adj Stat 16 (Threshold: 0.4) Nuclear Threshold Adj Stat 17 (Threshold: 0.2) Nuclear Threshold Adj Stat 17 (Threshold: 0.4) Nuclear Threshold Adj Stat 18 (Threshold: 0.2) Nuclear Threshold Adj Stat 18 (Threshold: 0.4) Nuclear Threshold Adj Stat 19 (Threshold: 0.2) Nuclear Threshold Adj Stat 19 (Threshold: 0.4) Nuclear Threshold Adj Stat 20 (Threshold: 0.2) Nuclear Threshold Adj Stat 20 (Threshold: 0.4) Nuclear Threshold Adj Stat 21 (Threshold: 0.2) Nuclear Threshold Adj Stat 21 (Threshold: 0.4) Nuclear Threshold Adj Stat 22 (Threshold: 0.2) Nuclear Threshold Adj Stat 22 (Threshold: 0.4) Nuclear Threshold Adj Stat 23 (Threshold: 0.2) Nuclear Threshold Adj Stat 23 (Threshold: 0.4) Nuclear Threshold Adj Stat 24 (Threshold: 0.2) Nuclear Threshold Adj Stat 24 (Threshold: 0.4) Nuclear Threshold Adj Stat 25 (Threshold: 0.2) Nuclear Threshold Adj Stat 25 (Threshold: 0.4) Nuclear Threshold Adj Stat 26 (Threshold: 0.2) Nuclear Threshold Adj Stat 26 (Threshold: 0.4) Nuclear Threshold Adj Stat 27 (Threshold: 0.2) Nuclear Threshold Adj Stat 27 (Threshold: 0.4) Nuclear Threshold Adj Stat 28 Nuclear Threshold Adj Stat 29 Nuclear Threshold Adj Stat 30 Nuclear Threshold Adj Stat 31 Nuclear Threshold Adj Stat 32 Nuclear Threshold Adj Stat 33 Nuclear Threshold Adj Stat 34 Nuclear Threshold Adj Stat 35 Nuclear Threshold Adj Stat 36 10% quantile of cytoplasm intensity (AU) 20% quantile of cytoplasm intensity (AU) 30% quantile of cytoplasm intensity (AU) 40% quantile of cytoplasm intensity (AU) 50% quantile of cytoplasm intensity (AU) 60% quantile of cytoplasm intensity (AU) 70% quantile of cytoplasm intensity (AU) 80% quantile of cytoplasm intensity (AU) 90% quantile of cytoplasm intensity (AU) Cytoplasmic Haralick ASM Cytoplasmic Haralick contrast Cytoplasmic Haralick entropy Cytoplasmic Haralick IDM Cytoplasmic Haralick moment 2 Cytoplasmic Haralick moment 3 Cytoplasmic Haralick moment 4 Cytoplasmic Haralick moment 5 Cytoplasmic radial moment (border) Cytoplasmic radial moment (center) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 28 Cytoplasmic Threshold Adj Stat 29 Cytoplasmic Threshold Adj Stat 30 Cytoplasmic Threshold Adj Stat 31 Cytoplasmic Threshold Adj Stat 32 Cytoplasmic Threshold Adj Stat 33 Cytoplasmic Threshold Adj Stat 34 Cytoplasmic Threshold Adj Stat 35 Cytoplasmic Threshold Adj Stat 36
SK-BR-3 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 1207 207 image if available 6980 19624 335.7 74.32 299.24 411.18 218 282 315 337 355 370 382 395 412 0.0495 972 0.878 105.01 22.67 2 0.0338 236 0.0016 18.87 6.802 0.2595 118201.0
43000000
16000000000
6030000000000
0.3992 0.2312 0.0008 0.0000 0.0019 0.0000 0.0057 0.0000 0.0151 0.0005 0.0362 0.0109 0.0496 0.0198 0.0603 0.0114 0.1042 0.0181 0.7262 0.9392 0.0000 0.0000 0.0000 0.0000 0.0003 0.0000 0.0033 0.0005 0.0117 0.0106 0.0200 0.0197 0.0164 0.0105 0.0219 0.0154 0.9264 0.9434 0.0234 0.1429 0.0263 0.0000 0.0536 0.4286 0.0623 0.2857 0.0837 0.1429 0.1003 0.0000 0.1120 0.0000 0.1324 0.0000 0.4060 0.0000 0.0007 0.0016 0.0028 0.0094 0.0211 0.0392 0.0446 0.0634 0.8170 12 16 20 28 78 180 350 599 943 0.0721 64.70 5.520 0.4930 258610.0
294000000
385000000000
559000000000000
0.4020 0.2305 0.0543 0.0023 0.2124 0.0098 0.3077 0.0976 0.1647 0.1574 0.1179 0.2237 0.0828 0.2003 0.0326 0.1140 0.0217 0.0910 0.0059 0.1039 0.0003 0.0000 0.0001 0.0001 0.0013 0.0004 0.0073 0.0059 0.0473 0.0415 0.0872 0.0708 0.0574 0.0514 0.0844 0.0737 0.7147 0.7561 0.0003 0.0002 0.0014 0.0008 0.0026 0.0025 0.0115 0.0140 0.0574 0.0661 0.1058 0.1190 0.0739 0.0814 0.1015 0.1092 0.6456 0.6068 0.0002 0.0005 0.0011 0.0070 0.0580 0.0920 0.0640 0.0926 0.6846
MDA-MB-231
0
DRAQ5 1 TMRE 2 2 2 1 937 792 image if available 9123 21746 335.0 60.34 75.58 106.02 251 283 304 322 338 352 368 385 407 0.0469 1020 1.203 88.96 31.32 2 0.0240 219 0.0031 5.79 6.087 0.3990 115860.0
41200000
15100000000
5640000000000
0.3775 0.2592 0.0006 0.0000 0.0019 0.0001 0.0030 0.0007 0.0099 0.0012 0.0231 0.0099 0.0367 0.0248 0.0410 0.0160 0.0611 0.0234 0.8226 0.9239 0.0001 0.0000 0.0004 0.0000 0.0010 0.0003 0.0037 0.0008 0.0116 0.0086 0.0156 0.0195 0.0156 0.0089 0.0230 0.0132 0.9290 0.9487 0.0127 0.0397 0.0136 0.0397 0.0363 0.1429 0.0417 0.1190 0.0644 0.1587 0.0816 0.1905 0.0743 0.0635 0.0988 0.0952 0.5766 0.1508 0.0021 0.0040 0.0109 0.0129 0.0253 0.0322 0.0430 0.0670 0.8026 6 7 9 13 26 46 79 134 219 0.0597 7.19 4.039 0.5263 16952.4
5760000
2510000000
1300000000000
0.3182 0.3239 0.0564 0.0038 0.1472 0.0263 0.2620 0.0928 0.1675 0.1276 0.1368 0.1702 0.0969 0.1688 0.0595 0.1401 0.0485 0.1159 0.0252 0.1545 0.0001 0.0005 0.0012 0.0006 0.0032 0.0031 0.0151 0.0112 0.0474 0.0451 0.0827 0.0582 0.0582 0.0542 0.0838 0.0756 0.7083 0.7517 0.0012 0.0002 0.0012 0.0019 0.0027 0.0043 0.0211 0.0249 0.0642 0.0784 0.1127 0.1071 0.0701 0.0779 0.0991 0.1155 0.6278 0.5898 0.0006 0.0010 0.0024 0.0164 0.0621 0.0942 0.0691 0.0956 0.6587
SK-BR-3 A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 406 653 image if available 9716 23603 431.9 88.96 349.44 405.84 326 380 406 425 442 459 475 495 525 0.0445 1051 1.155 114.98 44.01 1 0.0310 301 0.0009 57.02 7.395 0.1756 194415.0
90200000
42900000000
20900000000000
0.4256 0.2144 0.0000 0.0000 0.0001 0.0000 0.0024 0.0002 0.0073 0.0009 0.0306 0.0101 0.0644 0.0220 0.0617 0.0172 0.1018 0.0289 0.7315 0.9207 0.0000 0.0000 0.0000 0.0000 0.0001 0.0000 0.0014 0.0003 0.0115 0.0083 0.0248 0.0165 0.0200 0.0081 0.0331 0.0149 0.9091 0.9519 0.0122 0.0252 0.0157 0.0692 0.0332 0.0503 0.0752 0.1195 0.1461 0.2201 0.1785 0.1698 0.1400 0.0943 0.1417 0.1321 0.2572 0.1195 0.0002 0.0018 0.0031 0.0201 0.0458 0.0885 0.0915 0.1196 0.6294 11 15 26 74 177 311 477 692 979 0.0386 101.07 6.457 0.3962 286810.0
301000000
364000000000
491000000000000
0.5288 0.1335 0.0292 0.0023 0.1390 0.0075 0.2010 0.0674 0.1542 0.1168 0.1584 0.1632 0.1246 0.1791 0.0806 0.1344 0.0556 0.1290 0.0574 0.2002 0.0001 0.0001 0.0006 0.0003 0.0019 0.0007 0.0085 0.0046 0.0443 0.0358 0.0839 0.0706 0.0599 0.0519 0.0888 0.0796 0.7120 0.7564 0.0001 0.0003 0.0008 0.0014 0.0045 0.0043 0.0123 0.0170 0.0555 0.0621 0.1009 0.1122 0.0725 0.0814 0.1086 0.1185 0.6449 0.6027 0.0005 0.0014 0.0034 0.0121 0.0467 0.0905 0.0701 0.0917 0.6837
BT-20 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 199 260 image if available 10686 24087 343.1 42.34 218.62 243.80 294 309 319 329 339 349 361 376 398 0.0560 1348 1.108 80.65 27.02 2 0.0188 201 0.0020 20.94 6.553 0.2495 119532.0
42300000
15200000000
5550000000000
0.4430 0.2105 0.0001 0.0000 0.0002 0.0000 0.0012 0.0000 0.0032 0.0005 0.0194 0.0089 0.0355 0.0176 0.0461 0.0113 0.0755 0.0211 0.8188 0.9407 0.0000 0.0000 0.0000 0.0000 0.0001 0.0000 0.0015 0.0000 0.0114 0.0086 0.0212 0.0159 0.0232 0.0077 0.0352 0.0146 0.9074 0.9532 0.0199 0.0000 0.0385 0.0000 0.0442 0.0000 0.0855 0.0000 0.0954 0.0000 0.1311 0.0000 0.1197 0.0000 0.1211 0.0000 0.3447 0.0000 0.0047 0.0098 0.0155 0.0422 0.0674 0.0986 0.1131 0.1277 0.5211 18 23 29 46 110 198 297 422 589 0.0307 46.12 5.951 0.4302 107227.0
68300000
50200000000
40800000000000
0.5298 0.1259 0.0245 0.0018 0.1127 0.0149 0.2277 0.0610 0.1750 0.0972 0.1550 0.1809 0.1245 0.2068 0.0732 0.1277 0.0609 0.1204 0.0464 0.1894 0.0000 0.0000 0.0005 0.0002 0.0017 0.0016 0.0077 0.0073 0.0415 0.0338 0.0707 0.0588 0.0495 0.0417 0.0772 0.0625 0.7513 0.7941 0.0004 0.0004 0.0010 0.0016 0.0029 0.0041 0.0139 0.0205 0.0578 0.0653 0.0903 0.1105 0.0763 0.0890 0.1087 0.1110 0.6487 0.5975 0.0001 0.0011 0.0034 0.0105 0.0471 0.0826 0.0615 0.0887 0.7050
MDA-MB-231 A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 945 791 image if available 7136 8653 396.4 68.86 331.09 487.17 292 338 365 386 406 423 439 454 478 0.0953 825 1.046 109.66 38.48 6 0.0419 299 0.0024 9.08 6.362 0.3660 161888.0
67800000
29000000000
12700000000000
0.4181 0.2153 0.0006 0.0000 0.0015 0.0000 0.0038 0.0000 0.0079 0.0011 0.0218 0.0106 0.0533 0.0271 0.0385 0.0132 0.0585 0.0186 0.8142 0.9294 0.0000 0.0000 0.0002 0.0000 0.0005 0.0000 0.0025 0.0011 0.0113 0.0105 0.0289 0.0260 0.0141 0.0119 0.0204 0.0173 0.9222 0.9333 0.0066 0.0000 0.0066 0.0000 0.0263 0.0000 0.0447 0.0000 0.1092 0.0000 0.1184 0.0000 0.1158 0.0000 0.1382 0.0000 0.4342 0.0000 0.0005 0.0015 0.0051 0.0101 0.0281 0.0398 0.0367 0.0529 0.8252 10 12 15 26 85 211 381 631 998 0.1055 26.80 5.014 0.5502 346927.0
541000000
1110000000000
2.77E+15
0.4761 0.1685 0.0161 0.0031 0.0966 0.0086 0.1804 0.0350 0.1739 0.0871 0.1643 0.1540 0.1433 0.1882 0.0934 0.1407 0.0805 0.1198 0.0515 0.2636 0.0003 0.0008 0.0006 0.0014 0.0025 0.0017 0.0063 0.0068 0.0348 0.0256 0.0659 0.0501 0.0446 0.0400 0.0681 0.0535 0.7768 0.8202 0.0000 0.0004 0.0004 0.0018 0.0039 0.0049 0.0102 0.0123 0.0481 0.0511 0.0777 0.0886 0.0560 0.0675 0.0765 0.0825 0.7272 0.6909 0.0000 0.0004 0.0036 0.0093 0.0411 0.0750 0.0496 0.0650 0.7562
BT-20 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 1097 888 image if available 12238 26075 289.7 37.50 189.36 227.04 244 259 270 279 288 297 306 319 339 0.0439 1145 0.830 88.09 22.20 1 0.0187 229 0.0028 13.76 6.262 0.2992 85311.3
25500000
7770000000
2410000000000
0.4323 0.2203 0.0001 0.0000 0.0006 0.0000 0.0020 0.0000 0.0060 0.0003 0.0185 0.0078 0.0396 0.0156 0.0439 0.0098 0.0748 0.0169 0.8146 0.9496 0.0000 0.0000 0.0001 0.0000 0.0004 0.0000 0.0019 0.0001 0.0111 0.0076 0.0227 0.0147 0.0220 0.0071 0.0372 0.0112 0.9046 0.9593 0.0133 0.0000 0.0200 0.0000 0.0333 0.0000 0.0765 0.0000 0.1109 0.0000 0.1408 0.0000 0.1264 0.0000 0.1574 0.0000 0.3215 0.0000 0.0025 0.0088 0.0142 0.0239 0.0616 0.0902 0.0999 0.1291 0.5696 14 17 21 38 82 149 243 368 535 0.0346 41.52 5.730 0.4531 87402.9
53700000
38800000000
31400000000000
0.4360 0.2156 0.0618 0.0023 0.2087 0.0236 0.2420 0.1370 0.1346 0.1541 0.1098 0.1754 0.0927 0.1578 0.0590 0.0979 0.0495 0.0906 0.0418 0.1614 0.0001 0.0003 0.0003 0.0006 0.0015 0.0013 0.0103 0.0092 0.0495 0.0407 0.0808 0.0715 0.0648 0.0501 0.0944 0.0787 0.6983 0.7478 0.0000 0.0003 0.0007 0.0015 0.0026 0.0033 0.0159 0.0223 0.0664 0.0710 0.1136 0.1319 0.0845 0.0978 0.1225 0.1311 0.5939 0.5409 0.0004 0.0007 0.0021 0.0134 0.0562 0.0948 0.0755 0.1060 0.6510
MDA-MB-231 A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 1168 309 image if available 5738 14541 555.0 97.99 135.57 201.88 430 475 509 532 549 569 595 630 674 0.0558 812 1.022 61.39 19.31 1 0.0284 163 0.0013 20.75 6.963 0.2451 317645.0
187000000
114000000000
71800000000000
0.4110 0.2319 0.0002 0.0000 0.0005 0.0002 0.0016 0.0000 0.0094 0.0011 0.0237 0.0134 0.0434 0.0246 0.0556 0.0175 0.0657 0.0266 0.8000 0.9168 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0050 0.0002 0.0111 0.0115 0.0231 0.0207 0.0271 0.0101 0.0293 0.0171 0.9045 0.9404 0.0060 0.0000 0.0119 0.0000 0.0179 0.0000 0.0448 0.0000 0.0746 0.0000 0.0896 0.0000 0.0940 0.0000 0.1284 0.0000 0.5328 0.0000 0.0037 0.0078 0.0108 0.0257 0.0310 0.0518 0.0567 0.0712 0.7411 6 9 11 15 31 63 129 257 447 0.0557 17.52 4.450 0.4770 59131.7
35000000
24100000000
18500000000000
0.2802 0.3316 0.0685 0.0029 0.2066 0.0315 0.2433 0.1562 0.1601 0.1358 0.1039 0.1713 0.0844 0.1871 0.0648 0.1125 0.0391 0.0857 0.0293 0.1171 0.0000 0.0000 0.0002 0.0008 0.0017 0.0011 0.0106 0.0101 0.0494 0.0398 0.0811 0.0787 0.0552 0.0482 0.0684 0.0622 0.7334 0.7591 0.0000 0.0008 0.0005 0.0014 0.0036 0.0028 0.0137 0.0194 0.0588 0.0540 0.0975 0.1111 0.0629 0.0684 0.0890 0.0925 0.6741 0.6495 0.0002 0.0007 0.0019 0.0127 0.0514 0.0927 0.0561 0.0791 0.7052
MDA-MB-231 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 854 416 image if available 11131 15417 454.3 71.88 90.38 157.98 358 393 418 438 454 468 484 508 549 0.0688 1061 1.159 147.22 49.48 2 0.0314 350 0.0013 17.13 6.964 0.2615 211570.0
101000000
49300000000
24600000000000
0.4019 0.2435 0.0005 0.0000 0.0012 0.0001 0.0025 0.0005 0.0056 0.0007 0.0198 0.0107 0.0364 0.0188 0.0370 0.0124 0.0542 0.0178 0.8429 0.9388 0.0002 0.0000 0.0003 0.0000 0.0018 0.0000 0.0023 0.0002 0.0110 0.0093 0.0213 0.0169 0.0198 0.0089 0.0278 0.0138 0.9153 0.9509 0.0058 0.0159 0.0075 0.0397 0.0100 0.0556 0.0325 0.1270 0.0600 0.0873 0.0783 0.1349 0.0666 0.1111 0.0966 0.0952 0.6428 0.3333 0.0012 0.0023 0.0068 0.0178 0.0371 0.0570 0.0697 0.0892 0.7189 7 9 10 11 14 23 53 139 311 0.2296 12.11 3.590 0.7091 33126.6
17600000
11100000000
7920000000000
0.5835 0.1060 0.0228 0.0066 0.0791 0.0185 0.1263 0.0524 0.1948 0.0739 0.1933 0.1344 0.1522 0.1839 0.0898 0.1440 0.0883 0.1322 0.0533 0.2541 0.0000 0.0006 0.0012 0.0017 0.0021 0.0039 0.0062 0.0067 0.0321 0.0323 0.0482 0.0424 0.0349 0.0336 0.0634 0.0528 0.8120 0.8259 0.0011 0.0003 0.0031 0.0018 0.0025 0.0028 0.0098 0.0104 0.0419 0.0429 0.0613 0.0726 0.0526 0.0643 0.0793 0.0867 0.7482 0.7182 0.0003 0.0013 0.0028 0.0103 0.0339 0.0573 0.0419 0.0637 0.7885
SK-BR-3 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 518 503 image if available 15648 56021 320.9 59.50 142.33 181.99 244 279 299 315 329 341 354 368 389 0.0239 1341 0.987 126.85 36.01 1 0.0202 316 0.0015 21.65 6.855 0.2488 106538.0
36300000
12600000000
4480000000000
0.4413 0.2040 0.0005 0.0000 0.0005 0.0000 0.0020 0.0000 0.0079 0.0003 0.0295 0.0078 0.0562 0.0157 0.0615 0.0104 0.0915 0.0162 0.7503 0.9496 0.0000 0.0000 0.0000 0.0000 0.0002 0.0000 0.0023 0.0003 0.0109 0.0075 0.0242 0.0143 0.0210 0.0081 0.0316 0.0119 0.9098 0.9580 0.0090 0.0536 0.0157 0.0179 0.0336 0.1429 0.0745 0.2143 0.1272 0.1429 0.1557 0.1607 0.1429 0.1071 0.1597 0.0357 0.2818 0.1250 0.0008 0.0025 0.0050 0.0158 0.0410 0.0684 0.0815 0.0977 0.6873 8 10 12 18 51 108 178 269 424 0.1076 16.66 4.969 0.5393 53375.8
26600000
15300000000
9680000000000
0.3694 0.2725 0.0166 0.0013 0.1012 0.0060 0.2168 0.0361 0.1910 0.0912 0.1770 0.1724 0.1403 0.2115 0.0824 0.1547 0.0457 0.1475 0.0291 0.1792 0.0006 0.0002 0.0006 0.0006 0.0027 0.0015 0.0085 0.0065 0.0354 0.0299 0.0682 0.0565 0.0555 0.0459 0.0719 0.0641 0.7567 0.7947 0.0005 0.0005 0.0022 0.0022 0.0040 0.0048 0.0126 0.0154 0.0463 0.0551 0.0837 0.0934 0.0695 0.0743 0.0862 0.0911 0.6950 0.6633 0.0005 0.0017 0.0041 0.0114 0.0416 0.0737 0.0613 0.0797 0.7260
MDA-MB-231 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 708 397 image if available 15447 27394 562.4 113.78 118.30 212.73 394 458 507 542 576 606 636 667 703 0.0495 1356 0.896 108.19 30.00 3 0.0188 291 0.0006 29.72 7.605 0.2191 329218.0
199000000
124000000000
78600000000000
0.3988 0.2308 0.0014 0.0000 0.0019 0.0001 0.0040 0.0004 0.0105 0.0011 0.0269 0.0087 0.0473 0.0169 0.0485 0.0102 0.0672 0.0157 0.7922 0.9469 0.0001 0.0000 0.0002 0.0000 0.0005 0.0001 0.0023 0.0010 0.0107 0.0080 0.0188 0.0166 0.0160 0.0091 0.0204 0.0143 0.9310 0.9510 0.0029 0.0000 0.0095 0.0179 0.0147 0.0536 0.0297 0.1607 0.0612 0.1250 0.0718 0.1071 0.0872 0.2500 0.1213 0.1071 0.6015 0.1786 0.0008 0.0010 0.0032 0.0069 0.0226 0.0401 0.0411 0.0534 0.8309 7 9 10 11 12 15 40 206 467 0.3132 20.18 3.462 0.7115 59247.2
38200000
27600000000
21600000000000
0.5023 0.1444 0.0436 0.0036 0.1336 0.0128 0.2377 0.1026 0.1744 0.1354 0.1547 0.1810 0.1069 0.1882 0.0675 0.1055 0.0520 0.1119 0.0295 0.1589 0.0000 0.0003 0.0003 0.0004 0.0010 0.0004 0.0058 0.0038 0.0203 0.0189 0.0418 0.0353 0.0301 0.0220 0.0517 0.0418 0.8491 0.8771 0.0000 0.0000 0.0006 0.0005 0.0003 0.0005 0.0058 0.0079 0.0263 0.0302 0.0558 0.0631 0.0452 0.0492 0.0622 0.0705 0.8037 0.7782 0.0000 0.0000 0.0006 0.0049 0.0263 0.0486 0.0405 0.0571 0.8221
MDA-MB-231 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 200 513 image if available 11296 11224 660.4 94.02 95.02 136.71 543 587 617 640 661 683 708 735 774 0.1009 1133 0.918 133.74 44.91 2 0.0313 353 0.0006 79.90 7.739 0.1635 444990.0
305000000
213000000000
152000000000000
0.4251 0.2228 0.0000 0.0000 0.0005 0.0000 0.0017 0.0000 0.0042 0.0006 0.0187 0.0081 0.0399 0.0182 0.0436 0.0113 0.0656 0.0181 0.8257 0.9436 0.0000 0.0000 0.0002 0.0000 0.0006 0.0000 0.0022 0.0004 0.0107 0.0077 0.0240 0.0167 0.0219 0.0084 0.0314 0.0139 0.9090 0.9530 0.0074 0.0816 0.0173 0.0204 0.0222 0.0408 0.0937 0.2245 0.0912 0.2245 0.1307 0.2041 0.1097 0.0816 0.1233 0.1224 0.4044 0.0000 0.0016 0.0026 0.0092 0.0209 0.0527 0.0772 0.0800 0.1071 0.6486 12 16 20 27 38 53 81 138 272 0.0564 8.94 4.344 0.6275 27717.6
13300000
8080000000
5720000000000
0.4886 0.1747 0.0110 0.0020 0.0386 0.0109 0.0684 0.0288 0.1323 0.0387 0.2183 0.1107 0.1940 0.1846 0.1147 0.1166 0.1422 0.1509 0.0805 0.3568 0.0009 0.0007 0.0031 0.0037 0.0037 0.0072 0.0119 0.0120 0.0417 0.0400 0.0716 0.0744 0.0409 0.0423 0.0707 0.0596 0.7555 0.7601 0.0008 0.0004 0.0011 0.0022 0.0042 0.0043 0.0168 0.0173 0.0348 0.0381 0.0880 0.0934 0.0513 0.0510 0.0677 0.0636 0.7353 0.7297 0.0007 0.0010 0.0036 0.0116 0.0416 0.0819 0.0459 0.0714 0.7423
MDA-MB-231 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 305 753 image if available 14531 31502 446.4 61.03 117.13 162.48 365 402 424 439 452 464 476 491 515 0.0488 1538 0.844 110.02 27.80 4 0.0189 274 0.0017 18.96 6.823 0.2707 202963.0
93800000
44000000000
21000000000000
0.4307 0.2135 0.0003 0.0001 0.0001 0.0000 0.0009 0.0000 0.0036 0.0001 0.0149 0.0077 0.0284 0.0166 0.0253 0.0080 0.0383 0.0128 0.8882 0.9547 0.0001 0.0001 0.0000 0.0000 0.0000 0.0000 0.0019 0.0001 0.0098 0.0077 0.0186 0.0166 0.0149 0.0080 0.0188 0.0117 0.9360 0.9558 0.0148 1.0000 0.0239 0.0000 0.0091 0.0000 0.0262 0.0000 0.0809 0.0000 0.0945 0.0000 0.0809 0.0000 0.1173 0.0000 0.5524 0.0000 0.0022 0.0070 0.0123 0.0187 0.0346 0.0523 0.0642 0.0921 0.7167 13 16 21 33 52 79 118 180 305 0.0400 19.55 4.937 0.5597 40119.5
22800000
16800000000
14600000000000
0.4801 0.1897 0.0180 0.0019 0.0684 0.0102 0.1417 0.0304 0.1389 0.0605 0.1660 0.1385 0.1648 0.1775 0.1107 0.1263 0.1041 0.1394 0.0873 0.3154 0.0012 0.0003 0.0022 0.0020 0.0034 0.0030 0.0115 0.0124 0.0463 0.0387 0.0745 0.0614 0.0495 0.0472 0.0766 0.0656 0.7348 0.7694 0.0005 0.0007 0.0024 0.0020 0.0066 0.0068 0.0187 0.0217 0.0585 0.0622 0.0953 0.1084 0.0633 0.0699 0.0954 0.0979 0.6595 0.6304 0.0004 0.0017 0.0044 0.0151 0.0498 0.0888 0.0599 0.0831 0.6968
MDA-MB-231 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 673 661 image if available 8356 21692 629.4 88.97 157.77 200.04 505 558 588 612 637 660 678 703 736 0.0423 917 1.088 108.30 37.05 1 0.0333 278 0.0009 30.54 7.337 0.2196 404042.0
264000000
175000000000
118000000000000
0.4222 0.2219 0.0003 0.0000 0.0004 0.0000 0.0007 0.0000 0.0036 0.0002 0.0168 0.0091 0.0339 0.0170 0.0309 0.0087 0.0431 0.0141 0.8703 0.9508 0.0000 0.0000 0.0000 0.0000 0.0003 0.0000 0.0017 0.0002 0.0097 0.0091 0.0211 0.0170 0.0174 0.0087 0.0212 0.0141 0.9286 0.9508 0.0052 0.0000 0.0087 0.0000 0.0280 0.0000 0.0332 0.0000 0.0769 0.0000 0.1206 0.0000 0.0962 0.0000 0.1521 0.0000 0.4790 0.0000 0.0011 0.0031 0.0058 0.0105 0.0285 0.0524 0.0515 0.0731 0.7740 10 13 19 33 63 113 189 289 461 0.0633 29.43 5.277 0.5302 64906.9
36700000
24600000000
18400000000000
0.4278 0.2001 0.0270 0.0020 0.1224 0.0151 0.2282 0.0660 0.1787 0.1115 0.1483 0.1596 0.1201 0.2156 0.0684 0.1388 0.0615 0.1073 0.0454 0.1841 0.0001 0.0003 0.0002 0.0008 0.0015 0.0014 0.0077 0.0098 0.0437 0.0330 0.0678 0.0540 0.0479 0.0450 0.0793 0.0589 0.7519 0.7967 0.0005 0.0000 0.0015 0.0012 0.0026 0.0031 0.0122 0.0151 0.0611 0.0727 0.0953 0.1124 0.0662 0.0769 0.1035 0.1141 0.6570 0.6045 0.0001 0.0010 0.0024 0.0121 0.0486 0.0835 0.0554 0.0881 0.7087
BT-20 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 923 749 image if available 18485 19144 337.4 48.91 148.53 162.19 268 300 318 331 344 355 367 380 396 0.0705 1349 1.142 100.72 39.20 2 0.0147 271 0.0025 9.90 6.327 0.3429 116234.0
40800000
14500000000
5230000000000
0.4218 0.2181 0.0005 0.0000 0.0012 0.0001 0.0027 0.0001 0.0083 0.0008 0.0174 0.0071 0.0285 0.0145 0.0316 0.0074 0.0551 0.0119 0.8546 0.9581 0.0001 0.0000 0.0000 0.0001 0.0005 0.0001 0.0022 0.0008 0.0085 0.0071 0.0136 0.0145 0.0122 0.0074 0.0186 0.0119 0.9443 0.9581 0.0326 0.0000 0.0692 0.0000 0.0794 0.0000 0.1090 0.0000 0.1517 0.0000 0.1415 0.0000 0.1395 0.0000 0.1446 0.0000 0.1324 0.0000 0.0028 0.0050 0.0091 0.0138 0.0293 0.0412 0.0457 0.0737 0.7793 23 31 42 57 77 109 167 256 387 0.0183 13.36 5.441 0.5104 48364.8
22700000
12800000000
8140000000000
0.3890 0.2609 0.0233 0.0013 0.0952 0.0085 0.1700 0.0530 0.1578 0.1011 0.1966 0.1512 0.1445 0.1702 0.0908 0.1386 0.0714 0.1404 0.0504 0.2358 0.0001 0.0003 0.0008 0.0009 0.0026 0.0044 0.0128 0.0124 0.0492 0.0417 0.0708 0.0661 0.0547 0.0448 0.0827 0.0706 0.7262 0.7587 0.0007 0.0006 0.0009 0.0017 0.0035 0.0058 0.0196 0.0235 0.0581 0.0707 0.0989 0.0946 0.0629 0.0773 0.0941 0.1006 0.6612 0.6252 0.0000 0.0010 0.0043 0.0159 0.0522 0.0864 0.0570 0.0870 0.6963