High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)

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Cell SM Name Small Mol Concentration Small Mol Conc Unit Other Reagent 1 Name Other Reagent 1 Detection Channel Other Reagent 2 Name Other Reagent 2 Detection Channel Row Column Field X-coordinate Y-coordinate Image Nuclear area (pixels) Cytoplasm area (pixels) Nuclear intensity (AU) Std Dev of nuclear intensity (AU) Cytoplasm intensity (AU) Std Dev of cytoplasm intensity (AU) 10% quantile of nuclear intensity (AU) 20% quantile of nuclear intensity (AU) 30% quantile of nuclear intensity (AU) 40% quantile of nuclear intensity (AU) 50% quantile of nuclear intensity (AU) 60% quantile of nuclear intensity (AU) 70% quantile of nuclear intensity (AU) 80% quantile of nuclear intensity (AU) 90% quantile of nuclear intensity (AU) Ratio of cytoplasm perimeter to area Cytoplasm perimeter (pixels) Nuclear roundness Nuclear length (pixels) Nuclear halfwidth (pixels) Number of nuclei Ratio of nuclear perimeter to area Nuclear perimeter (pixels) Nuclear Haralick ASM Nuclear Haralick contrast Nuclear Haralick entropy Nuclear Haralick IDM Nuclear Haralick moment 2 Nuclear Haralick moment 3 Nuclear Haralick moment 4 Nuclear Haralick moment 5 Nuclear radial moment (border) Nuclear radial moment (center) Nuclear Threshold Adj Stat 1 (Threshold: 0.2) Nuclear Threshold Adj Stat 1 (Threshold: 0.4) Nuclear Threshold Adj Stat 2 (Threshold: 0.2) Nuclear Threshold Adj Stat 2 (Threshold: 0.4) Nuclear Threshold Adj Stat 3 (Threshold: 0.2) Nuclear Threshold Adj Stat 3 (Threshold: 0.4) Nuclear Threshold Adj Stat 4 (Threshold: 0.2) Nuclear Threshold Adj Stat 4 (Threshold: 0.4) Nuclear Threshold Adj Stat 5 (Threshold: 0.2) Nuclear Threshold Adj Stat 5 (Threshold: 0.4) Nuclear Threshold Adj Stat 6 (Threshold: 0.2) Nuclear Threshold Adj Stat 6 (Threshold: 0.4) Nuclear Threshold Adj Stat 7 (Threshold: 0.2) Nuclear Threshold Adj Stat 7 (Threshold: 0.4) Nuclear Threshold Adj Stat 8 (Threshold: 0.2) Nuclear Threshold Adj Stat 8 (Threshold: 0.4) Nuclear Threshold Adj Stat 9 (Threshold: 0.2) Nuclear Threshold Adj Stat 9 (Threshold: 0.4) Nuclear Threshold Adj Stat 10 (Threshold: 0.2) Nuclear Threshold Adj Stat 10 (Threshold: 0.4) Nuclear Threshold Adj Stat 11 (Threshold: 0.2) Nuclear Threshold Adj Stat 11 (Threshold: 0.4) Nuclear Threshold Adj Stat 12 (Threshold: 0.2) Nuclear Threshold Adj Stat 12 (Threshold: 0.4) Nuclear Threshold Adj Stat 13 (Threshold: 0.2) Nuclear Threshold Adj Stat 13 (Threshold: 0.4) Nuclear Threshold Adj Stat 14 (Threshold: 0.2) Nuclear Threshold Adj Stat 14 (Threshold: 0.4) Nuclear Threshold Adj Stat 15 (Threshold: 0.2) Nuclear Threshold Adj Stat 15 (Threshold: 0.4) Nuclear Threshold Adj Stat 16 (Threshold: 0.2) Nuclear Threshold Adj Stat 16 (Threshold: 0.4) Nuclear Threshold Adj Stat 17 (Threshold: 0.2) Nuclear Threshold Adj Stat 17 (Threshold: 0.4) Nuclear Threshold Adj Stat 18 (Threshold: 0.2) Nuclear Threshold Adj Stat 18 (Threshold: 0.4) Nuclear Threshold Adj Stat 19 (Threshold: 0.2) Nuclear Threshold Adj Stat 19 (Threshold: 0.4) Nuclear Threshold Adj Stat 20 (Threshold: 0.2) Nuclear Threshold Adj Stat 20 (Threshold: 0.4) Nuclear Threshold Adj Stat 21 (Threshold: 0.2) Nuclear Threshold Adj Stat 21 (Threshold: 0.4) Nuclear Threshold Adj Stat 22 (Threshold: 0.2) Nuclear Threshold Adj Stat 22 (Threshold: 0.4) Nuclear Threshold Adj Stat 23 (Threshold: 0.2) Nuclear Threshold Adj Stat 23 (Threshold: 0.4) Nuclear Threshold Adj Stat 24 (Threshold: 0.2) Nuclear Threshold Adj Stat 24 (Threshold: 0.4) Nuclear Threshold Adj Stat 25 (Threshold: 0.2) Nuclear Threshold Adj Stat 25 (Threshold: 0.4) Nuclear Threshold Adj Stat 26 (Threshold: 0.2) Nuclear Threshold Adj Stat 26 (Threshold: 0.4) Nuclear Threshold Adj Stat 27 (Threshold: 0.2) Nuclear Threshold Adj Stat 27 (Threshold: 0.4) Nuclear Threshold Adj Stat 28 Nuclear Threshold Adj Stat 29 Nuclear Threshold Adj Stat 30 Nuclear Threshold Adj Stat 31 Nuclear Threshold Adj Stat 32 Nuclear Threshold Adj Stat 33 Nuclear Threshold Adj Stat 34 Nuclear Threshold Adj Stat 35 Nuclear Threshold Adj Stat 36 10% quantile of cytoplasm intensity (AU) 20% quantile of cytoplasm intensity (AU) 30% quantile of cytoplasm intensity (AU) 40% quantile of cytoplasm intensity (AU) 50% quantile of cytoplasm intensity (AU) 60% quantile of cytoplasm intensity (AU) 70% quantile of cytoplasm intensity (AU) 80% quantile of cytoplasm intensity (AU) 90% quantile of cytoplasm intensity (AU) Cytoplasmic Haralick ASM Cytoplasmic Haralick contrast Cytoplasmic Haralick entropy Cytoplasmic Haralick IDM Cytoplasmic Haralick moment 2 Cytoplasmic Haralick moment 3 Cytoplasmic Haralick moment 4 Cytoplasmic Haralick moment 5 Cytoplasmic radial moment (border) Cytoplasmic radial moment (center) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 28 Cytoplasmic Threshold Adj Stat 29 Cytoplasmic Threshold Adj Stat 30 Cytoplasmic Threshold Adj Stat 31 Cytoplasmic Threshold Adj Stat 32 Cytoplasmic Threshold Adj Stat 33 Cytoplasmic Threshold Adj Stat 34 Cytoplasmic Threshold Adj Stat 35 Cytoplasmic Threshold Adj Stat 36
MDA-MB-231 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 149 240 image if available 6671 12334 390.0 50.74 109.56 270.04 317 352 374 389 399 409 419 431 446 0.0712 878 0.700 125.40 29.61 3 0.0475 317 0.0019 22.81 6.624 0.2349 154695.0
62200000
25300000000
10400000000000
0.4580 0.1948 0.0000 0.0000 0.0002 0.0000 0.0010 0.0000 0.0037 0.0003 0.0169 0.0112 0.0407 0.0210 0.0412 0.0134 0.0715 0.0187 0.8249 0.9354 0.0000 0.0000 0.0000 0.0000 0.0005 0.0000 0.0023 0.0003 0.0133 0.0112 0.0316 0.0210 0.0235 0.0134 0.0319 0.0187 0.8969 0.9354 0.1176 0.0000 0.1438 0.0000 0.1373 0.0000 0.1830 0.0000 0.1111 0.0000 0.1569 0.0000 0.0261 0.0000 0.0523 0.0000 0.0719 0.0000 0.0020 0.0033 0.0091 0.0202 0.0463 0.0663 0.0825 0.1189 0.6514 9 11 12 14 15 18 24 59 344 0.2142 6.81 2.736 0.6641 84919.1
101000000
144000000000
229000000000000
0.5929 0.1077 0.0204 0.0068 0.0980 0.0068 0.1592 0.0492 0.1878 0.0881 0.2082 0.1593 0.1755 0.1864 0.1020 0.1203 0.0367 0.1661 0.0122 0.2169 0.0005 0.0017 0.0019 0.0004 0.0014 0.0034 0.0052 0.0085 0.0331 0.0296 0.0553 0.0525 0.0355 0.0407 0.0766 0.0805 0.7905 0.7827 0.0000 0.0000 0.0000 0.0006 0.0021 0.0017 0.0064 0.0079 0.0380 0.0350 0.0545 0.0599 0.0401 0.0418 0.0866 0.0870 0.7722 0.7662 0.0000 0.0000 0.0020 0.0076 0.0289 0.0613 0.0370 0.0770 0.7863
SK-BR-3
0
DRAQ5 1 TMRE 2 2 2 1 837 568 image if available 3810 7691 452.3 131.47 221.21 376.57 230 356 426 457 480 503 528 553 586 0.0787 605 1.031 95.27 22.00 2 0.0559 213 0.0026 14.07 6.352 0.2995 221894.0
114000000
60800000000
33200000000000
0.3620 0.2645 0.0000 0.0000 0.0010 0.0000 0.0029 0.0000 0.0119 0.0016 0.0530 0.0188 0.0759 0.0350 0.0740 0.0220 0.1050 0.0373 0.6765 0.8854 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0013 0.0006 0.0145 0.0142 0.0290 0.0275 0.0145 0.0133 0.0244 0.0245 0.9162 0.9198 0.0021 0.0000 0.0054 0.0122 0.0171 0.0000 0.0289 0.0427 0.0567 0.1037 0.0739 0.0732 0.1017 0.1220 0.1210 0.0793 0.5931 0.5671 0.0004 0.0017 0.0021 0.0084 0.0261 0.0433 0.0517 0.0685 0.7977 9 14 18 23 32 56 165 387 734 0.0801 36.23 4.662 0.5714 190720.0
231000000
326000000000
505000000000000
0.5310 0.1283 0.0284 0.0000 0.2074 0.0058 0.3466 0.0902 0.1307 0.1645 0.1392 0.2082 0.0881 0.2475 0.0256 0.1092 0.0227 0.0975 0.0114 0.0771 0.0000 0.0000 0.0000 0.0000 0.0004 0.0008 0.0089 0.0041 0.0491 0.0454 0.0930 0.0827 0.0637 0.0458 0.0885 0.0827 0.6963 0.7387 0.0000 0.0006 0.0005 0.0011 0.0052 0.0017 0.0063 0.0112 0.0645 0.0730 0.1096 0.1162 0.0739 0.0691 0.1070 0.1072 0.6329 0.6199 0.0000 0.0005 0.0029 0.0082 0.0629 0.0936 0.0739 0.0975 0.6606
MCF7 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 841 100 image if available 7377 24941 386.3 96.75 88.88 190.82 262 298 330 360 385 408 433 466 515 0.0500 1246 0.563 94.76 26.17 2 0.0409 302 0.0008 47.55 7.415 0.1751 158588.0
68800000
31400000000
15000000000000
0.4311 0.2177 0.0002 0.0000 0.0031 0.0005 0.0070 0.0012 0.0283 0.0041 0.0813 0.0252 0.1505 0.0529 0.1401 0.0558 0.1607 0.0799 0.4286 0.7805 0.0000 0.0000 0.0011 0.0001 0.0023 0.0003 0.0099 0.0018 0.0340 0.0163 0.0593 0.0332 0.0508 0.0272 0.0661 0.0402 0.7764 0.8808 0.0040 0.0130 0.0066 0.0238 0.0139 0.0563 0.0615 0.0909 0.1315 0.1970 0.1606 0.1710 0.1269 0.1255 0.1401 0.1299 0.3549 0.1926 0.0005 0.0014 0.0043 0.0220 0.0674 0.1016 0.1003 0.1272 0.5753 4 5 7 8 10 12 18 103 322 0.1971 13.23 3.393 0.6457 44309.3
31100000
25500000000
23000000000000
0.4510 0.1554 0.0309 0.0028 0.1373 0.0130 0.2921 0.0763 0.2205 0.1516 0.1431 0.2140 0.0986 0.1898 0.0271 0.1395 0.0213 0.1116 0.0290 0.1014 0.0000 0.0003 0.0009 0.0005 0.0007 0.0016 0.0037 0.0063 0.0213 0.0191 0.0374 0.0318 0.0250 0.0278 0.0407 0.0377 0.8703 0.8748 0.0000 0.0002 0.0008 0.0004 0.0004 0.0019 0.0063 0.0064 0.0259 0.0282 0.0468 0.0526 0.0377 0.0404 0.0539 0.0614 0.8281 0.8084 0.0000 0.0004 0.0008 0.0042 0.0213 0.0423 0.0293 0.0477 0.8540
MCF7
0
DRAQ5 1 TMRE 2 2 2 1 307 284 image if available 4454 15705 541.8 126.10 114.66 191.51 395 434 463 491 521 551 591 651 728 0.0554 870 1.060 102.88 27.59 2 0.0534 238 0.0008 82.33 7.369 0.1665 309466.0
186000000
118000000000
78000000000000
0.4066 0.2345 0.0007 0.0000 0.0030 0.0000 0.0097 0.0005 0.0157 0.0027 0.0737 0.0261 0.1377 0.0438 0.1448 0.0443 0.1534 0.0597 0.4611 0.8229 0.0003 0.0000 0.0000 0.0000 0.0011 0.0000 0.0056 0.0002 0.0407 0.0161 0.0709 0.0258 0.0709 0.0192 0.0895 0.0269 0.7210 0.9117 0.0022 0.0032 0.0000 0.0160 0.0078 0.0415 0.0526 0.0927 0.0973 0.1629 0.1353 0.1502 0.0839 0.1086 0.1074 0.1438 0.5134 0.2812 0.0000 0.0031 0.0062 0.0333 0.0868 0.1149 0.1004 0.1108 0.5445 5 7 8 10 11 17 98 220 400 0.1818 28.75 4.115 0.6043 49820.4
29100000
19900000000
15300000000000
0.3528 0.2965 0.0222 0.0027 0.0974 0.0054 0.2530 0.0467 0.2085 0.0916 0.1880 0.2163 0.1333 0.2720 0.0496 0.1517 0.0222 0.1086 0.0256 0.1050 0.0000 0.0000 0.0002 0.0002 0.0010 0.0002 0.0025 0.0028 0.0223 0.0206 0.0377 0.0307 0.0289 0.0256 0.0466 0.0365 0.8607 0.8834 0.0005 0.0003 0.0002 0.0005 0.0002 0.0005 0.0059 0.0071 0.0334 0.0374 0.0541 0.0695 0.0498 0.0450 0.0636 0.0730 0.7923 0.7666 0.0002 0.0000 0.0004 0.0042 0.0271 0.0491 0.0391 0.0560 0.8237
MDA-MB-231 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 708 397 image if available 15447 27394 562.4 113.78 118.30 212.73 394 458 507 542 576 606 636 667 703 0.0495 1356 0.896 108.19 30.00 3 0.0188 291 0.0006 29.72 7.605 0.2191 329218.0
199000000
124000000000
78600000000000
0.3988 0.2308 0.0014 0.0000 0.0019 0.0001 0.0040 0.0004 0.0105 0.0011 0.0269 0.0087 0.0473 0.0169 0.0485 0.0102 0.0672 0.0157 0.7922 0.9469 0.0001 0.0000 0.0002 0.0000 0.0005 0.0001 0.0023 0.0010 0.0107 0.0080 0.0188 0.0166 0.0160 0.0091 0.0204 0.0143 0.9310 0.9510 0.0029 0.0000 0.0095 0.0179 0.0147 0.0536 0.0297 0.1607 0.0612 0.1250 0.0718 0.1071 0.0872 0.2500 0.1213 0.1071 0.6015 0.1786 0.0008 0.0010 0.0032 0.0069 0.0226 0.0401 0.0411 0.0534 0.8309 7 9 10 11 12 15 40 206 467 0.3132 20.18 3.462 0.7115 59247.2
38200000
27600000000
21600000000000
0.5023 0.1444 0.0436 0.0036 0.1336 0.0128 0.2377 0.1026 0.1744 0.1354 0.1547 0.1810 0.1069 0.1882 0.0675 0.1055 0.0520 0.1119 0.0295 0.1589 0.0000 0.0003 0.0003 0.0004 0.0010 0.0004 0.0058 0.0038 0.0203 0.0189 0.0418 0.0353 0.0301 0.0220 0.0517 0.0418 0.8491 0.8771 0.0000 0.0000 0.0006 0.0005 0.0003 0.0005 0.0058 0.0079 0.0263 0.0302 0.0558 0.0631 0.0452 0.0492 0.0622 0.0705 0.8037 0.7782 0.0000 0.0000 0.0006 0.0049 0.0263 0.0486 0.0405 0.0571 0.8221
MCF7 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 779 704 image if available 5803 19960 372.2 94.00 225.74 412.23 264 293 318 338 360 380 408 444 501 0.0479 957 1.184 131.46 56.92 1 0.0622 361 0.0010 43.53 7.206 0.1938 147377.0
62100000
27800000000
13200000000000
0.4343 0.2158 0.0000 0.0000 0.0015 0.0000 0.0085 0.0004 0.0188 0.0023 0.0689 0.0252 0.1544 0.0502 0.1354 0.0473 0.1582 0.0622 0.4544 0.8124 0.0000 0.0000 0.0004 0.0000 0.0015 0.0000 0.0071 0.0011 0.0331 0.0145 0.0767 0.0294 0.0663 0.0230 0.0802 0.0308 0.7347 0.9013 0.0000 0.0044 0.0062 0.0066 0.0213 0.0022 0.0364 0.0744 0.1058 0.1510 0.1538 0.1707 0.0809 0.1204 0.1200 0.1554 0.4756 0.3151 0.0020 0.0016 0.0110 0.0292 0.0817 0.1310 0.0781 0.1097 0.5558 8 10 11 13 15 26 121 400 845 0.2506 60.02 4.037 0.6340 220884.0
291000000
452000000000
796000000000000
0.4139 0.2037 0.0722 0.0028 0.2071 0.0270 0.2425 0.1555 0.1403 0.1634 0.1104 0.1811 0.0872 0.1783 0.0490 0.0909 0.0504 0.0831 0.0409 0.1179 0.0000 0.0000 0.0002 0.0000 0.0000 0.0007 0.0062 0.0044 0.0375 0.0329 0.0543 0.0543 0.0439 0.0317 0.0639 0.0529 0.7941 0.8231 0.0002 0.0000 0.0008 0.0011 0.0008 0.0013 0.0057 0.0067 0.0481 0.0528 0.0740 0.0799 0.0481 0.0528 0.0838 0.0860 0.7384 0.7192 0.0000 0.0004 0.0002 0.0082 0.0430 0.0638 0.0522 0.0724 0.7598
MDA-MB-231 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 1191 273 image if available 5225 11025 340.7 62.23 307.66 490.68 248 283 309 330 349 367 381 396 416 0.0786 867 0.925 79.06 24.04 4 0.0404 211 0.0014 23.53 6.846 0.2524 119949.0
43400000
16100000000
6080000000000
0.4363 0.2015 0.0005 0.0000 0.0024 0.0000 0.0052 0.0004 0.0144 0.0012 0.0415 0.0155 0.0735 0.0306 0.0749 0.0196 0.1045 0.0333 0.6830 0.8994 0.0002 0.0000 0.0009 0.0000 0.0014 0.0004 0.0046 0.0012 0.0191 0.0153 0.0353 0.0304 0.0290 0.0163 0.0376 0.0273 0.8719 0.9093 0.0076 0.0000 0.0291 1.0000 0.0443 0.0000 0.0581 0.0000 0.1407 0.0000 0.1361 0.0000 0.1300 0.0000 0.1529 0.0000 0.3012 0.0000 0.0007 0.0021 0.0070 0.0115 0.0369 0.0518 0.0539 0.0869 0.7493 8 10 12 16 25 61 277 673 1103 0.0635 24.60 4.331 0.4441 335399.0
461000000
722000000000
1.24E+15
0.5061 0.1164 0.0746 0.0000 0.2293 0.0218 0.2541 0.1592 0.1602 0.1687 0.1409 0.2082 0.0829 0.1891 0.0304 0.0898 0.0193 0.0939 0.0083 0.0694 0.0000 0.0000 0.0006 0.0006 0.0038 0.0011 0.0065 0.0047 0.0332 0.0356 0.0632 0.0601 0.0397 0.0361 0.0585 0.0593 0.7947 0.8025 0.0003 0.0003 0.0007 0.0003 0.0023 0.0017 0.0056 0.0055 0.0391 0.0464 0.0687 0.0695 0.0444 0.0488 0.0736 0.0768 0.7653 0.7506 0.0003 0.0012 0.0016 0.0068 0.0346 0.0626 0.0392 0.0688 0.7849
MDA-MB-231 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 740 703 image if available 8862 18824 530.1 80.43 114.15 251.56 421 467 496 517 535 553 573 598 631 0.0548 1032 0.545 114.22 22.67 5 0.0372 330 0.0009 38.41 7.314 0.2073 287452.0
159000000
89500000000
51200000000000
0.4491 0.2025 0.0001 0.0000 0.0006 0.0000 0.0007 0.0001 0.0056 0.0007 0.0282 0.0139 0.0564 0.0200 0.0512 0.0144 0.0715 0.0211 0.7858 0.9298 0.0000 0.0000 0.0000 0.0000 0.0000 0.0001 0.0016 0.0007 0.0179 0.0139 0.0306 0.0200 0.0252 0.0144 0.0335 0.0202 0.8913 0.9307 0.0075 1.0000 0.0188 0.0000 0.0225 0.0000 0.0476 0.0000 0.1164 0.0000 0.1640 0.0000 0.1014 0.0000 0.1502 0.0000 0.3717 0.0000 0.0006 0.0036 0.0074 0.0181 0.0434 0.0613 0.0734 0.0863 0.7059 9 10 12 13 15 20 38 121 352 0.1429 9.00 3.049 0.5952 76308.2
79500000
99600000000
139000000000000
0.5235 0.1294 0.0259 0.0023 0.0761 0.0164 0.2120 0.0561 0.1942 0.0865 0.2006 0.1645 0.1003 0.2050 0.1036 0.1458 0.0631 0.1341 0.0243 0.1894 0.0000 0.0004 0.0002 0.0004 0.0012 0.0011 0.0067 0.0072 0.0396 0.0383 0.0538 0.0475 0.0401 0.0385 0.0569 0.0591 0.8015 0.8073 0.0003 0.0000 0.0006 0.0006 0.0017 0.0021 0.0056 0.0079 0.0476 0.0539 0.0673 0.0667 0.0437 0.0521 0.0707 0.0758 0.7625 0.7409 0.0000 0.0005 0.0016 0.0065 0.0428 0.0586 0.0418 0.0664 0.7819
MCF7 A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 623 128 image if available 5953 11599 530.3 117.08 264.39 415.53 392 428 458 485 513 546 584 630 696 0.0813 943 0.967 130.08 35.78 1 0.0519 309 0.0004 120.83 7.914 0.1104 294936.0
172000000
105000000000
66500000000000
0.4302 0.2128 0.0000 0.0000 0.0008 0.0002 0.0059 0.0004 0.0185 0.0013 0.0765 0.0215 0.1506 0.0396 0.1458 0.0420 0.1956 0.0637 0.4064 0.8314 0.0000 0.0000 0.0006 0.0000 0.0035 0.0000 0.0076 0.0003 0.0384 0.0137 0.0657 0.0215 0.0657 0.0178 0.0966 0.0280 0.7218 0.9187 0.0044 0.0061 0.0000 0.0214 0.0142 0.0428 0.0567 0.1284 0.1258 0.1743 0.1709 0.2110 0.1116 0.1376 0.1515 0.1407 0.3649 0.1376 0.0015 0.0015 0.0083 0.0326 0.0701 0.1227 0.0848 0.1148 0.5638 9 12 15 20 32 87 235 532 918 0.0999 84.61 5.018 0.5316 242548.0
294000000
414000000000
650000000000000
0.4380 0.2212 0.0713 0.0000 0.2240 0.0143 0.2261 0.1554 0.1344 0.1964 0.1303 0.1954 0.0876 0.1573 0.0448 0.0925 0.0407 0.0944 0.0407 0.0944 0.0006 0.0000 0.0003 0.0013 0.0014 0.0020 0.0089 0.0075 0.0371 0.0362 0.0674 0.0619 0.0438 0.0415 0.0726 0.0714 0.7680 0.7782 0.0006 0.0000 0.0000 0.0007 0.0013 0.0014 0.0055 0.0051 0.0375 0.0471 0.0789 0.0792 0.0465 0.0567 0.0818 0.0857 0.7478 0.7240 0.0003 0.0030 0.0021 0.0087 0.0382 0.0659 0.0454 0.0728 0.7636
MCF 10A A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 703 330 image if available 1517 7267 260.9 69.91 59.78 117.99 178 191 206 227 248 274 304 331 369 0.0860 625 1.115 107.79 38.05 1 0.1793 272 0.0105 1.72 4.763 0.5649 72953.0
21700000
6830000000
2240000000000
0.3508 0.2996 0.0016 0.0000 0.0031 0.0000 0.0062 0.0015 0.0171 0.0067 0.0715 0.0340 0.0964 0.0503 0.1026 0.0392 0.1291 0.0673 0.5723 0.8010 0.0010 0.0000 0.0019 0.0000 0.0019 0.0000 0.0057 0.0040 0.0306 0.0224 0.0373 0.0369 0.0335 0.0257 0.0450 0.0383 0.8431 0.8727 0.0025 0.0000 0.0000 0.0000 0.0100 0.0061 0.0124 0.0549 0.0423 0.0610 0.0547 0.0549 0.0448 0.1220 0.0821 0.0854 0.7512 0.6159 0.0000 0.0029 0.0015 0.0059 0.0337 0.0527 0.0366 0.0439 0.8228 7 8 9 10 11 15 28 57 188 0.1752 2.71 2.781 0.6871 17493.2
7830000
4090000000
2340000000000
0.4255 0.2007 0.0273 0.0043 0.0648 0.0086 0.1297 0.0114 0.2150 0.0643 0.2116 0.1186 0.1502 0.1686 0.1229 0.1429 0.0614 0.1629 0.0171 0.3186 0.0031 0.0010 0.0037 0.0021 0.0074 0.0026 0.0155 0.0129 0.0372 0.0290 0.0440 0.0403 0.0415 0.0445 0.0551 0.0672 0.7926 0.8004 0.0000 0.0000 0.0030 0.0000 0.0023 0.0024 0.0053 0.0097 0.0371 0.0308 0.0393 0.0559 0.0446 0.0454 0.0598 0.0608 0.8086 0.7950 0.0000 0.0021 0.0049 0.0119 0.0295 0.0372 0.0400 0.0534 0.8209
MCF7 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 1052 727 image if available 435 10158 216.6 37.95 134.54 228.49 169 184 193 205 215 223 235 249 268 0.0475 483 1.039 156.49 50.48 1 0.9218 401 0.0052 14.90 5.415 0.3014 48369.5
11100000
2630000000
636000000000
0.4349 0.2080 0.0000 0.0000 0.0096 0.0000 0.0096 0.0000 0.0382 0.0047 0.1019 0.0606 0.1656 0.0629 0.1624 0.0606 0.1943 0.0956 0.3185 0.7156 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0186 0.0023 0.0849 0.0621 0.1088 0.0552 0.0928 0.0437 0.1432 0.0759 0.5517 0.7609 0.0000 0.1667 0.0000 0.0000 0.0635 0.1667 0.1905 0.3333 0.1429 0.3333 0.2540 0.0000 0.1270 0.0000 0.0635 0.0000 0.1587 0.0000 0.0000 0.0095 0.0237 0.0616 0.1754 0.1469 0.1280 0.1801 0.2749 5 7 8 9 11 16 98 264 495 0.1308 20.25 3.815 0.5357 70302.5
49000000
40900000000
40000000000000
0.5326 0.1283 0.0600 0.0028 0.2086 0.0308 0.2229 0.1413 0.2086 0.1636 0.1400 0.2070 0.0686 0.1930 0.0514 0.1035 0.0371 0.0867 0.0029 0.0713 0.0000 0.0000 0.0000 0.0000 0.0003 0.0000 0.0037 0.0047 0.0269 0.0233 0.0561 0.0472 0.0326 0.0315 0.0668 0.0585 0.8136 0.8348 0.0000 0.0000 0.0004 0.0004 0.0011 0.0020 0.0049 0.0053 0.0377 0.0422 0.0681 0.0763 0.0518 0.0666 0.0883 0.0849 0.7477 0.7223 0.0000 0.0000 0.0011 0.0029 0.0350 0.0622 0.0404 0.0733 0.7851
MCF7 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 710 226 image if available 10638 31624 385.7 96.25 128.74 201.92 261 301 330 358 383 410 437 468 511 0.0395 1248 1.125 80.96 32.70 1 0.0205 218 0.0007 46.96 7.474 0.1736 158052.0
68300000
30900000000
14600000000000
0.4592 0.1972 0.0007 0.0000 0.0012 0.0000 0.0092 0.0002 0.0215 0.0023 0.0807 0.0217 0.1548 0.0477 0.1521 0.0530 0.1775 0.0756 0.4023 0.7994 0.0004 0.0000 0.0006 0.0000 0.0029 0.0000 0.0071 0.0011 0.0308 0.0141 0.0563 0.0286 0.0517 0.0248 0.0718 0.0362 0.7784 0.8951 0.0031 0.0050 0.0093 0.0268 0.0194 0.0385 0.0552 0.1122 0.1254 0.2111 0.1762 0.1960 0.1219 0.1122 0.1524 0.1374 0.3370 0.1608 0.0006 0.0025 0.0046 0.0208 0.0594 0.1029 0.0892 0.1124 0.6077 6 7 8 10 13 26 121 273 445 0.1884 22.33 4.262 0.6114 57343.9
33100000
22000000000
16300000000000
0.4979 0.1312 0.0634 0.0031 0.2215 0.0274 0.3281 0.1449 0.1801 0.1860 0.1167 0.2111 0.0542 0.1939 0.0193 0.0950 0.0119 0.0923 0.0046 0.0464 0.0001 0.0002 0.0001 0.0007 0.0014 0.0009 0.0035 0.0033 0.0325 0.0296 0.0490 0.0435 0.0394 0.0311 0.0566 0.0537 0.8173 0.8370 0.0000 0.0000 0.0000 0.0004 0.0002 0.0006 0.0049 0.0057 0.0367 0.0435 0.0707 0.0771 0.0468 0.0543 0.0747 0.0844 0.7660 0.7341 0.0000 0.0002 0.0005 0.0052 0.0314 0.0597 0.0456 0.0609 0.7964
SK-BR-3 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 1108 239 image if available 5108 12529 286.7 70.87 214.74 352.40 171 236 266 284 299 315 328 344 365 0.0797 998 0.558 111.13 15.52 4 0.0484 247 0.0020 16.33 6.555 0.2615 87243.0
27600000
9000000000
3000000000000
0.3894 0.2353 0.0003 0.0000 0.0013 0.0000 0.0025 0.0004 0.0143 0.0011 0.0584 0.0180 0.0901 0.0332 0.0841 0.0276 0.1336 0.0427 0.6155 0.8769 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0005 0.0007 0.0180 0.0141 0.0245 0.0255 0.0159 0.0137 0.0327 0.0196 0.9084 0.9264 0.0060 0.0200 0.0109 0.1000 0.0268 0.1400 0.0625 0.1500 0.1240 0.1900 0.1488 0.1800 0.1399 0.1200 0.1290 0.0700 0.3522 0.0300 0.0013 0.0007 0.0040 0.0131 0.0368 0.0646 0.0703 0.1078 0.7014 8 10 13 17 22 32 138 460 810 0.1100 11.85 3.914 0.5579 170291.0
167000000
181000000000
211000000000000
0.5996 0.0926 0.0347 0.0084 0.1262 0.0139 0.2429 0.0446 0.1767 0.0990 0.2019 0.1660 0.1703 0.2106 0.0315 0.1381 0.0126 0.1367 0.0032 0.1827 0.0006 0.0000 0.0006 0.0000 0.0014 0.0003 0.0037 0.0024 0.0292 0.0286 0.0404 0.0329 0.0388 0.0347 0.0584 0.0583 0.8270 0.8428 0.0000 0.0006 0.0000 0.0010 0.0012 0.0003 0.0040 0.0055 0.0339 0.0372 0.0456 0.0486 0.0395 0.0466 0.0688 0.0696 0.8070 0.7905 0.0000 0.0000 0.0006 0.0038 0.0337 0.0391 0.0399 0.0609 0.8219
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 568 142 image if available 3390 3676 488.2 76.89 55.99 95.47 384 420 448 473 493 513 533 556 587 0.1317 484 0.859 109.18 23.32 5 0.0752 255 0.0012 41.51 6.959 0.2091 244289.0
125000000
65200000000
34600000000000
0.4456 0.2022 0.0000 0.0000 0.0000 0.0000 0.0019 0.0000 0.0133 0.0009 0.0451 0.0139 0.0863 0.0237 0.0833 0.0160 0.1064 0.0261 0.6638 0.9194 0.0000 0.0000 0.0000 0.0000 0.0003 0.0000 0.0050 0.0009 0.0220 0.0139 0.0441 0.0237 0.0414 0.0154 0.0588 0.0231 0.8284 0.9230 0.0028 0.0000 0.0113 1.0000 0.0395 0.0000 0.1073 0.0000 0.1638 0.0000 0.2147 0.0000 0.1243 0.0000 0.1356 0.0000 0.2006 0.0000 0.0006 0.0017 0.0045 0.0195 0.0658 0.1155 0.1016 0.1267 0.5642 9 11 12 14 17 20 25 75 169 0.1554 6.68 3.147 0.7267 12247.2
4240000
1770000000
834000000000
0.4752 0.1492 0.0192 0.0284 0.0769 0.0355 0.1731 0.1277 0.3462 0.1489 0.1346 0.1915 0.1346 0.1773 0.1154 0.1206 0.0000 0.0709 0.0000 0.0993 0.0000 0.0046 0.0025 0.0058 0.0012 0.0116 0.0037 0.0127 0.0160 0.0197 0.0197 0.0313 0.0271 0.0174 0.0406 0.0440 0.8892 0.8530 0.0000 0.0000 0.0000 0.0000 0.0026 0.0028 0.0039 0.0083 0.0211 0.0221 0.0316 0.0456 0.0395 0.0415 0.0684 0.0692 0.8329 0.8105 0.0000 0.0000 0.0013 0.0038 0.0189 0.0215 0.0278 0.0556 0.8712