High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
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Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
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MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 652 | 166 | 1359 | 6119 | 428.9 | 60.31 | 32.37 | 70.62 | 351 | 373 | 390 | 405 | 426 | 446 | 465 | 483 | 508 | 0.0709 | 434 | 0.794 | 97.08 | 19.70 | 1 | 0.1670 | 227 | 0.0023 | 22.07 | 6.272 | 0.2405 | 187585.0 | 83600000 | 38000000000 | 17500000000000 | 0.4204 | 0.2216 | 0.0009 | 0.0000 | 0.0000 | 0.0000 | 0.0026 | 0.0000 | 0.0061 | 0.0000 | 0.0462 | 0.0221 | 0.0688 | 0.0324 | 0.0592 | 0.0191 | 0.0897 | 0.0316 | 0.7265 | 0.8948 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0024 | 0.0000 | 0.0016 | 0.0000 | 0.0293 | 0.0221 | 0.0443 | 0.0324 | 0.0332 | 0.0191 | 0.0546 | 0.0316 | 0.8347 | 0.8948 | 0.0259 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0776 | 0.0000 | 0.1638 | 0.0000 | 0.1983 | 0.0000 | 0.1207 | 0.0000 | 0.1379 | 0.0000 | 0.2759 | 0.0000 | 0.0000 | 0.0046 | 0.0077 | 0.0107 | 0.0475 | 0.0644 | 0.0706 | 0.0982 | 0.6963 | 6 | 8 | 9 | 10 | 11 | 13 | 15 | 23 | 79 | 0.3514 | 3.58 | 2.313 | 0.8106 | 6034.5 | 2460000 | 1350000000 | 863000000000 | 0.6003 | 0.1052 | 0.0807 | 0.0227 | 0.0807 | 0.0644 | 0.1211 | 0.0814 | 0.2870 | 0.1458 | 0.1435 | 0.1496 | 0.1480 | 0.1458 | 0.0762 | 0.1326 | 0.0583 | 0.1307 | 0.0045 | 0.1269 | 0.0088 | 0.0079 | 0.0044 | 0.0186 | 0.0071 | 0.0193 | 0.0274 | 0.0336 | 0.0398 | 0.0480 | 0.0548 | 0.0523 | 0.0610 | 0.0651 | 0.0839 | 0.0938 | 0.7129 | 0.6614 | 0.0000 | 0.0000 | 0.0044 | 0.0023 | 0.0055 | 0.0046 | 0.0143 | 0.0161 | 0.0539 | 0.0506 | 0.0462 | 0.0598 | 0.0616 | 0.0529 | 0.0935 | 0.0978 | 0.7206 | 0.7158 | 0.0020 | 0.0050 | 0.0090 | 0.0160 | 0.0548 | 0.0439 | 0.0499 | 0.1017 | 0.7178 | |
SK-BR-3 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1178 | 149 | 2587 | 12832 | 62.1 | 10.66 | 74.22 | 169.03 | 47 | 54 | 57 | 60 | 63 | 65 | 68 | 71 | 75 | 0.0646 | 829 | 0.944 | 80.06 | 19.03 | 2 | 0.0723 | 187 | 0.0369 | 1.29 | 3.638 | 0.6360 | 3969.1 | 260301 | 17500000 | 1200000000 | 0.4305 | 0.2137 | 0.0020 | 0.0000 | 0.0020 | 0.0004 | 0.0055 | 0.0008 | 0.0201 | 0.0075 | 0.0472 | 0.0210 | 0.0693 | 0.0334 | 0.0844 | 0.0346 | 0.1920 | 0.0516 | 0.5774 | 0.8507 | 0.0004 | 0.0000 | 0.0004 | 0.0000 | 0.0018 | 0.0004 | 0.0079 | 0.0059 | 0.0238 | 0.0192 | 0.0331 | 0.0298 | 0.0348 | 0.0271 | 0.0591 | 0.0365 | 0.8386 | 0.8811 | 0.0719 | 0.0968 | 0.1079 | 0.1290 | 0.0755 | 0.1935 | 0.1151 | 0.0968 | 0.1043 | 0.1613 | 0.1187 | 0.1613 | 0.1475 | 0.0968 | 0.0827 | 0.0645 | 0.1763 | 0.0000 | 0.0036 | 0.0107 | 0.0220 | 0.0377 | 0.0519 | 0.0732 | 0.1087 | 0.1741 | 0.5181 | 15 | 19 | 23 | 28 | 32 | 38 | 43 | 50 | 94 | 0.1646 | 3.32 | 2.652 | 0.8090 | 34078.2 | 30400000 | 31700000000 | 35800000000000 | 0.6942 | 0.0754 | 0.1033 | 0.0274 | 0.0813 | 0.0364 | 0.0769 | 0.0502 | 0.0769 | 0.0707 | 0.1319 | 0.1021 | 0.1275 | 0.1360 | 0.1319 | 0.1585 | 0.1275 | 0.1667 | 0.1429 | 0.2520 | 0.0237 | 0.0180 | 0.0188 | 0.0239 | 0.0094 | 0.0319 | 0.0066 | 0.0430 | 0.0248 | 0.0663 | 0.0370 | 0.0857 | 0.0304 | 0.1021 | 0.0679 | 0.1201 | 0.7815 | 0.5089 | 0.0044 | 0.0017 | 0.0044 | 0.0035 | 0.0074 | 0.0095 | 0.0118 | 0.0173 | 0.0376 | 0.0528 | 0.0516 | 0.0692 | 0.0553 | 0.0614 | 0.1061 | 0.0882 | 0.7214 | 0.6964 | 0.0006 | 0.0038 | 0.0038 | 0.0101 | 0.0258 | 0.0396 | 0.0491 | 0.0931 | 0.7742 | |
MCF7 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 214 | 329 | 2935 | 11303 | 279.9 | 61.40 | 6.40 | 2.56 | 193 | 217 | 240 | 262 | 283 | 300 | 320 | 339 | 363 | 0.0572 | 646 | 0.707 | 220.60 | 68.41 | 1 | 0.2290 | 672 | 0.0038 | 5.82 | 5.792 | 0.3874 | 82100.6 | 25100000 | 7920000000 | 2580000000000 | 0.3742 | 0.2640 | 0.0012 | 0.0000 | 0.0055 | 0.0000 | 0.0068 | 0.0003 | 0.0197 | 0.0035 | 0.0419 | 0.0219 | 0.0653 | 0.0299 | 0.0635 | 0.0285 | 0.1054 | 0.0597 | 0.6907 | 0.8563 | 0.0009 | 0.0000 | 0.0018 | 0.0000 | 0.0013 | 0.0003 | 0.0075 | 0.0027 | 0.0168 | 0.0196 | 0.0266 | 0.0240 | 0.0239 | 0.0192 | 0.0350 | 0.0343 | 0.8862 | 0.8998 | 0.0031 | 0.1875 | 0.0126 | 0.2813 | 0.0173 | 0.3750 | 0.0346 | 0.0938 | 0.0456 | 0.0625 | 0.0566 | 0.0000 | 0.0629 | 0.0000 | 0.0849 | 0.0000 | 0.6824 | 0.0000 | 0.0013 | 0.0020 | 0.0059 | 0.0092 | 0.0277 | 0.0323 | 0.0323 | 0.0554 | 0.8339 | 3 | 4 | 5 | 6 | 6 | 7 | 8 | 9 | 10 | 0.4396 | 0.38 | 1.169 | 0.8081 | 47.5 | 391.249 | 3512.14 | 33881.8 | 0.4867 | 0.1660 | 0.0087 | 0.0004 | 0.0533 | 0.0075 | 0.1339 | 0.0348 | 0.2382 | 0.1039 | 0.2579 | 0.1830 | 0.1883 | 0.2424 | 0.0921 | 0.2426 | 0.0230 | 0.1419 | 0.0046 | 0.0434 | 0.0002 | 0.0000 | 0.0018 | 0.0009 | 0.0097 | 0.0035 | 0.0393 | 0.0162 | 0.0799 | 0.0427 | 0.1426 | 0.0876 | 0.2155 | 0.1902 | 0.2757 | 0.3292 | 0.2352 | 0.3297 | 0.0810 | 0.1861 | 0.1648 | 0.2753 | 0.2049 | 0.2537 | 0.1900 | 0.1433 | 0.1511 | 0.0792 | 0.1073 | 0.0385 | 0.0628 | 0.0186 | 0.0300 | 0.0043 | 0.0081 | 0.0009 | 0.0035 | 0.0243 | 0.0659 | 0.1244 | 0.1728 | 0.2058 | 0.2030 | 0.1370 | 0.0633 | |
Hs 578T | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 164 | 879 | 4050 | 8872 | 419.4 | 110.73 | 86.10 | 234.18 | 295 | 334 | 362 | 385 | 409 | 439 | 474 | 515 | 570 | 0.0979 | 869 | 0.960 | 155.00 | 54.01 | 3 | 0.1049 | 425 | 0.0007 | 76.29 | 7.489 | 0.1602 | 188142.0 | 89200000 | 44400000000 | 23100000000000 | 0.4137 | 0.2255 | 0.0004 | 0.0000 | 0.0017 | 0.0000 | 0.0052 | 0.0000 | 0.0231 | 0.0043 | 0.0718 | 0.0210 | 0.1144 | 0.0459 | 0.1271 | 0.0397 | 0.1462 | 0.0559 | 0.5100 | 0.8333 | 0.0003 | 0.0000 | 0.0006 | 0.0000 | 0.0019 | 0.0000 | 0.0071 | 0.0013 | 0.0298 | 0.0149 | 0.0481 | 0.0238 | 0.0528 | 0.0149 | 0.0708 | 0.0245 | 0.7886 | 0.9206 | 0.0011 | 0.0000 | 0.0043 | 0.0099 | 0.0130 | 0.0099 | 0.0444 | 0.0759 | 0.0704 | 0.1452 | 0.1083 | 0.1716 | 0.0986 | 0.1089 | 0.1073 | 0.1584 | 0.5525 | 0.3201 | 0.0016 | 0.0032 | 0.0111 | 0.0185 | 0.0506 | 0.0749 | 0.0611 | 0.0870 | 0.6921 | 11 | 12 | 14 | 15 | 16 | 17 | 20 | 35 | 226 | 0.4982 | 14.49 | 2.220 | 0.8059 | 62249.3 | 81200000 | 135000000000 | 258000000000000 | 0.6303 | 0.0763 | 0.2131 | 0.0132 | 0.4262 | 0.1376 | 0.2295 | 0.3995 | 0.0546 | 0.1508 | 0.0546 | 0.1164 | 0.0219 | 0.1085 | 0.0000 | 0.0423 | 0.0000 | 0.0265 | 0.0000 | 0.0053 | 0.0007 | 0.0006 | 0.0055 | 0.0019 | 0.0097 | 0.0070 | 0.0194 | 0.0171 | 0.0947 | 0.0912 | 0.1418 | 0.1476 | 0.0705 | 0.0646 | 0.0961 | 0.0956 | 0.5615 | 0.5744 | 0.0008 | 0.0008 | 0.0032 | 0.0042 | 0.0071 | 0.0100 | 0.0301 | 0.0308 | 0.1013 | 0.1032 | 0.1362 | 0.1424 | 0.0831 | 0.0849 | 0.1077 | 0.1091 | 0.5305 | 0.5146 | 0.0022 | 0.0037 | 0.0066 | 0.0176 | 0.1051 | 0.1412 | 0.0713 | 0.1037 | 0.5485 | |
MDA-MB-231 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 701 | 317 | 1010 | 1709 | 117.2 | 14.08 | 14.40 | 13.12 | 99 | 104 | 109 | 112 | 117 | 120 | 125 | 130 | 137 | 0.2264 | 387 | 0.804 | 89.94 | 22.63 | 3 | 0.2515 | 254 | 0.0285 | 1.46 | 3.784 | 0.5971 | 13944.3 | 1680000 | 206000000 | 25500000000 | 0.4094 | 0.2171 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0032 | 0.0010 | 0.0173 | 0.0079 | 0.0539 | 0.0366 | 0.0949 | 0.0772 | 0.0949 | 0.0475 | 0.1284 | 0.0554 | 0.6063 | 0.7743 | 0.0000 | 0.0000 | 0.0010 | 0.0000 | 0.0031 | 0.0010 | 0.0153 | 0.0079 | 0.0408 | 0.0366 | 0.0704 | 0.0772 | 0.0551 | 0.0475 | 0.0643 | 0.0554 | 0.7500 | 0.7743 | 0.0755 | 0.0000 | 0.0566 | 0.0000 | 0.0755 | 0.0000 | 0.3019 | 0.0000 | 0.1509 | 0.0000 | 0.1698 | 0.0000 | 0.0566 | 0.0000 | 0.0755 | 0.0000 | 0.0377 | 0.0000 | 0.0000 | 0.0119 | 0.0119 | 0.0356 | 0.0652 | 0.1047 | 0.1126 | 0.1285 | 0.5296 | 6 | 7 | 8 | 9 | 10 | 12 | 14 | 18 | 27 | 0.2146 | 0.58 | 2.293 | 0.8004 | 379.5 | 17210.3 | 1060000 | 75400000 | 0.6023 | 0.1002 | 0.1389 | 0.0185 | 0.1528 | 0.0420 | 0.1910 | 0.0791 | 0.2014 | 0.1471 | 0.1632 | 0.1483 | 0.0868 | 0.1508 | 0.0417 | 0.1434 | 0.0243 | 0.1434 | 0.0000 | 0.1273 | 0.0532 | 0.0116 | 0.0388 | 0.0268 | 0.0403 | 0.0528 | 0.0446 | 0.0966 | 0.0935 | 0.1109 | 0.1410 | 0.1270 | 0.0777 | 0.1064 | 0.1410 | 0.1145 | 0.3698 | 0.3533 | 0.0197 | 0.0032 | 0.0221 | 0.0194 | 0.0246 | 0.0227 | 0.0491 | 0.0680 | 0.1302 | 0.1262 | 0.1474 | 0.1780 | 0.1179 | 0.1197 | 0.1843 | 0.1586 | 0.3047 | 0.3042 | 0.0209 | 0.0209 | 0.0342 | 0.0512 | 0.0892 | 0.1518 | 0.0854 | 0.1613 | 0.3852 | |
MCF 10A | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 95 | 131 | 989 | 1640 | 89.4 | 13.84 | 29.47 | 62.84 | 71 | 77 | 82 | 85 | 89 | 93 | 96 | 101 | 107 | 0.2116 | 347 | 0.177 | 169.76 | 32.53 | 2 | 0.8817 | 872 | 0.0651 | 1.08 | 3.063 | 0.6829 | 8181.5 | 766522 | 73500000 | 7210000000 | 0.3997 | 0.2450 | 0.0013 | 0.0000 | 0.0025 | 0.0000 | 0.0063 | 0.0000 | 0.0304 | 0.0061 | 0.0608 | 0.0348 | 0.0989 | 0.0583 | 0.1343 | 0.0409 | 0.1926 | 0.0502 | 0.4728 | 0.8096 | 0.0011 | 0.0000 | 0.0011 | 0.0000 | 0.0022 | 0.0000 | 0.0169 | 0.0051 | 0.0371 | 0.0293 | 0.0573 | 0.0526 | 0.0629 | 0.0303 | 0.0843 | 0.0415 | 0.7371 | 0.8413 | 0.0594 | 0.0000 | 0.1089 | 0.3333 | 0.1188 | 0.2500 | 0.1485 | 0.2500 | 0.1485 | 0.0833 | 0.1782 | 0.0833 | 0.0594 | 0.0000 | 0.0792 | 0.0000 | 0.0990 | 0.0000 | 0.0019 | 0.0077 | 0.0232 | 0.0522 | 0.0754 | 0.1006 | 0.1528 | 0.2147 | 0.3714 | 8 | 10 | 12 | 13 | 15 | 17 | 20 | 26 | 43 | 0.3370 | 1.57 | 1.900 | 0.7940 | 4815.1 | 2160000 | 1340000000 | 961000000000 | 0.6590 | 0.0663 | 0.0476 | 0.0571 | 0.1429 | 0.0571 | 0.1905 | 0.0813 | 0.2434 | 0.1099 | 0.2487 | 0.1429 | 0.0794 | 0.1868 | 0.0476 | 0.1890 | 0.0000 | 0.1341 | 0.0000 | 0.0418 | 0.0128 | 0.0413 | 0.0434 | 0.0366 | 0.0561 | 0.0461 | 0.0918 | 0.0636 | 0.1429 | 0.0986 | 0.1709 | 0.1574 | 0.1301 | 0.1558 | 0.1071 | 0.1558 | 0.2449 | 0.2448 | 0.0246 | 0.0057 | 0.0148 | 0.0230 | 0.0296 | 0.0345 | 0.0788 | 0.0575 | 0.1478 | 0.1609 | 0.1773 | 0.2126 | 0.1281 | 0.1149 | 0.1232 | 0.1437 | 0.2759 | 0.2471 | 0.0223 | 0.0335 | 0.0520 | 0.0632 | 0.1561 | 0.1710 | 0.1227 | 0.1190 | 0.2602 | |
MCF7 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 590 | 585 | 6499 | 12657 | 474.1 | 105.05 | 39.01 | 84.66 | 344 | 379 | 410 | 438 | 465 | 494 | 525 | 566 | 619 | 0.0658 | 833 | 0.436 | 85.09 | 24.33 | 2 | 0.0495 | 322 | 0.0005 | 98.02 | 7.849 | 0.1181 | 235821.0 | 123000000 | 66600000000 | 37500000000000 | 0.4186 | 0.2373 | 0.0003 | 0.0000 | 0.0010 | 0.0000 | 0.0081 | 0.0002 | 0.0234 | 0.0021 | 0.0846 | 0.0185 | 0.1319 | 0.0439 | 0.1403 | 0.0446 | 0.1617 | 0.0662 | 0.4487 | 0.8246 | 0.0002 | 0.0000 | 0.0000 | 0.0000 | 0.0017 | 0.0000 | 0.0075 | 0.0012 | 0.0359 | 0.0131 | 0.0667 | 0.0284 | 0.0658 | 0.0201 | 0.0850 | 0.0339 | 0.7372 | 0.9033 | 0.0024 | 0.0066 | 0.0072 | 0.0197 | 0.0168 | 0.0623 | 0.0455 | 0.1049 | 0.1310 | 0.2164 | 0.1566 | 0.1934 | 0.1054 | 0.1213 | 0.1454 | 0.1016 | 0.3898 | 0.1738 | 0.0007 | 0.0013 | 0.0093 | 0.0251 | 0.0753 | 0.1245 | 0.0951 | 0.1176 | 0.5510 | 8 | 10 | 11 | 13 | 14 | 16 | 20 | 32 | 83 | 0.3458 | 2.93 | 2.365 | 0.7930 | 8689.1 | 4200000 | 2620000000 | 1850000000000 | 0.5811 | 0.1080 | 0.0885 | 0.0104 | 0.2543 | 0.0345 | 0.2812 | 0.1127 | 0.1438 | 0.1577 | 0.1011 | 0.2117 | 0.0616 | 0.1837 | 0.0442 | 0.1186 | 0.0221 | 0.0840 | 0.0032 | 0.0866 | 0.0012 | 0.0043 | 0.0039 | 0.0074 | 0.0075 | 0.0086 | 0.0365 | 0.0296 | 0.0821 | 0.0734 | 0.1147 | 0.0932 | 0.0825 | 0.0839 | 0.1222 | 0.1175 | 0.5495 | 0.5820 | 0.0016 | 0.0023 | 0.0031 | 0.0012 | 0.0047 | 0.0059 | 0.0350 | 0.0457 | 0.0957 | 0.1019 | 0.1479 | 0.1547 | 0.0883 | 0.0873 | 0.1181 | 0.1131 | 0.5055 | 0.4880 | 0.0009 | 0.0059 | 0.0054 | 0.0345 | 0.0917 | 0.1226 | 0.0903 | 0.1207 | 0.5279 | |
MDA-MB-231 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 387 | 777 | 3566 | 6931 | 639.4 | 107.04 | 10.06 | 4.66 | 486 | 547 | 588 | 620 | 651 | 674 | 700 | 732 | 773 | 0.0884 | 613 | 1.124 | 98.72 | 31.38 | 1 | 0.0670 | 239 | 0.0010 | 36.61 | 7.121 | 0.1989 | 420338.0 | 283000000 | 195000000000 | 137000000000000 | 0.3984 | 0.2382 | 0.0011 | 0.0000 | 0.0011 | 0.0000 | 0.0053 | 0.0000 | 0.0083 | 0.0003 | 0.0320 | 0.0164 | 0.0531 | 0.0288 | 0.0531 | 0.0164 | 0.0753 | 0.0257 | 0.7708 | 0.9124 | 0.0007 | 0.0000 | 0.0000 | 0.0000 | 0.0007 | 0.0000 | 0.0029 | 0.0003 | 0.0186 | 0.0158 | 0.0258 | 0.0270 | 0.0225 | 0.0141 | 0.0287 | 0.0217 | 0.9000 | 0.9211 | 0.0000 | 0.0000 | 0.0149 | 0.1667 | 0.0446 | 0.0833 | 0.0718 | 0.2500 | 0.0767 | 0.2500 | 0.1287 | 0.2500 | 0.0965 | 0.0000 | 0.1658 | 0.0000 | 0.4010 | 0.0000 | 0.0010 | 0.0005 | 0.0021 | 0.0124 | 0.0361 | 0.0465 | 0.0589 | 0.0780 | 0.7646 | 5 | 7 | 7 | 8 | 9 | 10 | 12 | 13 | 16 | 0.4127 | 0.30 | 1.079 | 0.7896 | 122.9 | 1790.87 | 30353.2 | 582290 | 0.5361 | 0.1291 | 0.0335 | 0.0045 | 0.0959 | 0.0139 | 0.1633 | 0.0252 | 0.2000 | 0.0536 | 0.2138 | 0.0902 | 0.1661 | 0.1532 | 0.0951 | 0.2086 | 0.0264 | 0.2648 | 0.0059 | 0.1859 | 0.0097 | 0.0003 | 0.0311 | 0.0027 | 0.0593 | 0.0058 | 0.0757 | 0.0236 | 0.0929 | 0.0587 | 0.1048 | 0.1040 | 0.1018 | 0.1321 | 0.1193 | 0.1860 | 0.4054 | 0.4869 | 0.0652 | 0.0615 | 0.0666 | 0.0608 | 0.0576 | 0.0615 | 0.0566 | 0.0660 | 0.0756 | 0.0801 | 0.0809 | 0.1008 | 0.0856 | 0.1127 | 0.1365 | 0.1579 | 0.3754 | 0.2987 | 0.0501 | 0.0714 | 0.0772 | 0.0740 | 0.0778 | 0.0730 | 0.0804 | 0.1126 | 0.3836 | |||
MCF 10A | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 181 | 254 | 1614 | 11324 | 1117.5 | 296.73 | 9.91 | 3.01 | 735 | 828 | 914 | 1000 | 1089 | 1176 | 1265 | 1423 | 1565 | 0.0770 | 872 | 1.072 | 79.08 | 22.56 | 2 | 0.1121 | 181 | 0.0011 | 52.02 | 6.977 | 0.1957 | 1340000.0 | 1700000000 | 2270000000000 | 3.16E+15 | 0.3925 | 0.2330 | 0.0013 | 0.0000 | 0.0000 | 0.0007 | 0.0000 | 0.0043 | 0.0090 | 0.0078 | 0.0859 | 0.0456 | 0.1538 | 0.0820 | 0.1013 | 0.0520 | 0.1115 | 0.0834 | 0.5372 | 0.7242 | 0.0009 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0026 | 0.0043 | 0.0058 | 0.0445 | 0.0358 | 0.0676 | 0.0588 | 0.0360 | 0.0371 | 0.0668 | 0.0543 | 0.7800 | 0.8056 | 0.0000 | 0.0000 | 0.0000 | 0.0062 | 0.0000 | 0.0124 | 0.0103 | 0.0248 | 0.0490 | 0.0745 | 0.0979 | 0.1242 | 0.0515 | 0.0745 | 0.0670 | 0.1304 | 0.7242 | 0.5528 | 0.0000 | 0.0000 | 0.0013 | 0.0066 | 0.0584 | 0.0717 | 0.0491 | 0.0704 | 0.7424 | 6 | 7 | 8 | 9 | 10 | 11 | 11 | 12 | 14 | 0.4427 | 0.33 | 0.894 | 0.7893 | 107.3 | 1247.66 | 15428.7 | 201459 | 0.5329 | 0.1343 | 0.0090 | 0.0001 | 0.0432 | 0.0015 | 0.1219 | 0.0064 | 0.2092 | 0.0237 | 0.2630 | 0.0647 | 0.2046 | 0.1320 | 0.1129 | 0.2428 | 0.0316 | 0.3164 | 0.0048 | 0.2124 | 0.0001 | 0.0000 | 0.0019 | 0.0002 | 0.0112 | 0.0008 | 0.0360 | 0.0079 | 0.0843 | 0.0254 | 0.1595 | 0.0409 | 0.2364 | 0.0926 | 0.2711 | 0.2669 | 0.1995 | 0.5654 | 0.0875 | 0.2991 | 0.1970 | 0.2991 | 0.2239 | 0.2057 | 0.2071 | 0.1218 | 0.1517 | 0.0503 | 0.0847 | 0.0160 | 0.0376 | 0.0044 | 0.0092 | 0.0036 | 0.0012 | 0.0000 | 0.0072 | 0.0439 | 0.0969 | 0.1605 | 0.2046 | 0.1989 | 0.1608 | 0.0959 | 0.0313 | |
SK-BR-3 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1017 | 174 | 1248 | 1851 | 214.5 | 155.04 | 45.32 | 44.12 | 105 | 122 | 135 | 145 | 159 | 175 | 196 | 246 | 453 | 0.2150 | 398 | 0.886 | 138.05 | 45.25 | 2 | 0.3045 | 380 | 0.0030 | 54.71 | 6.166 | 0.2695 | 70037.8 | 33300000 | 19600000000 | 12700000000000 | 0.3408 | 0.2642 | 0.0000 | 0.0014 | 0.0105 | 0.0000 | 0.0592 | 0.0027 | 0.0941 | 0.0095 | 0.2056 | 0.0846 | 0.1638 | 0.1419 | 0.0906 | 0.1132 | 0.1289 | 0.1050 | 0.2474 | 0.5416 | 0.0000 | 0.0011 | 0.0000 | 0.0000 | 0.0076 | 0.0011 | 0.0191 | 0.0085 | 0.0841 | 0.0512 | 0.1071 | 0.0800 | 0.0650 | 0.0597 | 0.1071 | 0.0778 | 0.6099 | 0.7207 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0169 | 0.0098 | 0.0805 | 0.1073 | 0.1059 | 0.1024 | 0.0551 | 0.0488 | 0.0975 | 0.1024 | 0.6441 | 0.6293 | 0.0032 | 0.0097 | 0.0097 | 0.0130 | 0.0909 | 0.0942 | 0.0390 | 0.1039 | 0.6364 | 20 | 22 | 25 | 27 | 30 | 34 | 39 | 51 | 87 | 0.1634 | 0.96 | 2.528 | 0.7872 | 4000.0 | 623754 | 127000000 | 29000000000 | 0.5672 | 0.0956 | 0.0344 | 0.0145 | 0.0875 | 0.0190 | 0.1375 | 0.0335 | 0.1313 | 0.0760 | 0.1906 | 0.1229 | 0.2000 | 0.1508 | 0.1156 | 0.1620 | 0.0688 | 0.1721 | 0.0344 | 0.2492 | 0.0106 | 0.0111 | 0.0257 | 0.0146 | 0.0287 | 0.0231 | 0.0332 | 0.0446 | 0.0861 | 0.0788 | 0.1344 | 0.0925 | 0.1239 | 0.1071 | 0.1360 | 0.1500 | 0.4215 | 0.4781 | 0.0029 | 0.0037 | 0.0088 | 0.0368 | 0.0205 | 0.0404 | 0.0526 | 0.0772 | 0.1404 | 0.0919 | 0.1725 | 0.1287 | 0.1023 | 0.1213 | 0.1287 | 0.1103 | 0.3713 | 0.3897 | 0.0022 | 0.0155 | 0.0310 | 0.0376 | 0.1062 | 0.1372 | 0.1261 | 0.1482 | 0.3960 | |
MDA-MB-231 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 680 | 102 | 4304 | 6744 | 541.8 | 144.02 | 32.62 | 45.34 | 329 | 395 | 450 | 516 | 566 | 606 | 638 | 670 | 705 | 0.0948 | 639 | 0.542 | 117.00 | 26.02 | 1 | 0.0853 | 367 | 0.0008 | 32.43 | 7.325 | 0.2185 | 314288.0 | 192000000 | 122000000000 | 80400000000000 | 0.3875 | 0.2444 | 0.0010 | 0.0000 | 0.0025 | 0.0003 | 0.0069 | 0.0003 | 0.0212 | 0.0022 | 0.0562 | 0.0210 | 0.0877 | 0.0339 | 0.0946 | 0.0234 | 0.1252 | 0.0358 | 0.6047 | 0.8831 | 0.0000 | 0.0000 | 0.0000 | 0.0003 | 0.0006 | 0.0003 | 0.0044 | 0.0015 | 0.0197 | 0.0172 | 0.0292 | 0.0288 | 0.0251 | 0.0175 | 0.0368 | 0.0275 | 0.8842 | 0.9070 | 0.0000 | 0.0000 | 0.0080 | 0.0000 | 0.0187 | 0.0000 | 0.0276 | 0.0000 | 0.0480 | 0.0000 | 0.0730 | 0.0000 | 0.0747 | 0.0000 | 0.1103 | 0.0000 | 0.6397 | 1.0000 | 0.0000 | 0.0013 | 0.0017 | 0.0055 | 0.0233 | 0.0355 | 0.0364 | 0.0508 | 0.8455 | 8 | 9 | 11 | 12 | 15 | 18 | 26 | 44 | 83 | 0.2567 | 1.27 | 2.377 | 0.7837 | 3119.9 | 589671 | 172000000 | 67600000000 | 0.6419 | 0.0827 | 0.0252 | 0.0246 | 0.1124 | 0.0419 | 0.1550 | 0.0583 | 0.2190 | 0.0887 | 0.1725 | 0.1297 | 0.1570 | 0.1478 | 0.1066 | 0.1445 | 0.0504 | 0.1650 | 0.0019 | 0.1995 | 0.0035 | 0.0115 | 0.0080 | 0.0167 | 0.0141 | 0.0199 | 0.0251 | 0.0267 | 0.0693 | 0.0554 | 0.1065 | 0.0940 | 0.0749 | 0.0737 | 0.0965 | 0.0992 | 0.6020 | 0.6029 | 0.0034 | 0.0031 | 0.0054 | 0.0085 | 0.0075 | 0.0124 | 0.0360 | 0.0325 | 0.0658 | 0.0688 | 0.1126 | 0.1145 | 0.0855 | 0.0828 | 0.1119 | 0.1121 | 0.5719 | 0.5654 | 0.0012 | 0.0070 | 0.0153 | 0.0282 | 0.0728 | 0.1045 | 0.0752 | 0.1057 | 0.5901 | |
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 818 | 411 | 1111 | 7364 | 67.7 | 19.08 | 51.50 | 75.73 | 43 | 51 | 58 | 63 | 67 | 72 | 77 | 83 | 92 | 0.0743 | 547 | 0.895 | 205.46 | 68.66 | 1 | 0.5041 | 560 | 0.0025 | 26.29 | 6.146 | 0.2030 | 4951.3 | 386036 | 31800000 | 2760000000 | 0.4919 | 0.1558 | 0.0017 | 0.0000 | 0.0084 | 0.0000 | 0.0506 | 0.0042 | 0.0759 | 0.0116 | 0.1433 | 0.0582 | 0.1855 | 0.0857 | 0.1484 | 0.1228 | 0.2024 | 0.1185 | 0.1838 | 0.5989 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0237 | 0.0078 | 0.0580 | 0.0447 | 0.1018 | 0.0438 | 0.0994 | 0.0720 | 0.1515 | 0.0730 | 0.5657 | 0.7588 | 0.0198 | 0.0241 | 0.0238 | 0.0361 | 0.0437 | 0.1566 | 0.1032 | 0.2289 | 0.1468 | 0.1325 | 0.2103 | 0.1687 | 0.1071 | 0.0602 | 0.1151 | 0.0482 | 0.2302 | 0.1446 | 0.0000 | 0.0036 | 0.0163 | 0.0470 | 0.1501 | 0.1410 | 0.1338 | 0.1591 | 0.3490 | 15 | 17 | 18 | 21 | 24 | 29 | 39 | 59 | 117 | 0.2303 | 3.57 | 2.698 | 0.7805 | 8387.2 | 2780000 | 1260000000 | 683000000000 | 0.4695 | 0.1988 | 0.0338 | 0.0076 | 0.1132 | 0.0146 | 0.2294 | 0.0419 | 0.1779 | 0.1017 | 0.1647 | 0.1773 | 0.1250 | 0.1919 | 0.0632 | 0.1582 | 0.0662 | 0.1264 | 0.0265 | 0.1804 | 0.0057 | 0.0035 | 0.0047 | 0.0053 | 0.0095 | 0.0114 | 0.0218 | 0.0252 | 0.0816 | 0.0650 | 0.1044 | 0.0919 | 0.0745 | 0.0831 | 0.1144 | 0.1136 | 0.5833 | 0.6010 | 0.0007 | 0.0016 | 0.0042 | 0.0032 | 0.0049 | 0.0048 | 0.0329 | 0.0322 | 0.0988 | 0.0893 | 0.1142 | 0.1376 | 0.0883 | 0.0837 | 0.1065 | 0.1255 | 0.5494 | 0.5221 | 0.0029 | 0.0041 | 0.0088 | 0.0269 | 0.0779 | 0.1265 | 0.0715 | 0.1154 | 0.5659 | |
SK-BR-3 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 1130 | 267 | 5490 | 23038 | 164.0 | 66.56 | 28.31 | 61.33 | 83 | 103 | 121 | 140 | 156 | 173 | 190 | 215 | 271 | 0.0512 | 1180 | 0.983 | 61.59 | 20.03 | 5 | 0.0288 | 158 | 0.0023 | 6.37 | 6.316 | 0.3881 | 31316.4 | 6760000 | 1600000000 | 408000000000 | 0.3733 | 0.2534 | 0.0000 | 0.0000 | 0.0019 | 0.0025 | 0.0077 | 0.0028 | 0.0178 | 0.0083 | 0.0548 | 0.0230 | 0.0836 | 0.0418 | 0.1000 | 0.0452 | 0.1629 | 0.0593 | 0.5714 | 0.8171 | 0.0000 | 0.0000 | 0.0011 | 0.0015 | 0.0023 | 0.0018 | 0.0056 | 0.0051 | 0.0158 | 0.0124 | 0.0237 | 0.0218 | 0.0259 | 0.0218 | 0.0440 | 0.0294 | 0.8816 | 0.9062 | 0.0027 | 0.0011 | 0.0075 | 0.0054 | 0.0137 | 0.0087 | 0.0239 | 0.0130 | 0.0321 | 0.0369 | 0.0498 | 0.0510 | 0.0546 | 0.0304 | 0.0539 | 0.0542 | 0.7618 | 0.7993 | 0.0000 | 0.0012 | 0.0056 | 0.0164 | 0.0308 | 0.0504 | 0.0496 | 0.0712 | 0.7747 | 7 | 9 | 10 | 12 | 13 | 15 | 18 | 25 | 46 | 0.1947 | 4.25 | 2.622 | 0.7761 | 4562.8 | 1730000 | 803000000 | 408000000000 | 0.5689 | 0.1210 | 0.0523 | 0.0587 | 0.0562 | 0.0581 | 0.0812 | 0.0637 | 0.1251 | 0.0665 | 0.1413 | 0.0729 | 0.1613 | 0.0863 | 0.1935 | 0.0999 | 0.1268 | 0.1500 | 0.0623 | 0.3441 | 0.0140 | 0.0361 | 0.0138 | 0.0353 | 0.0177 | 0.0353 | 0.0272 | 0.0346 | 0.0400 | 0.0414 | 0.0560 | 0.0533 | 0.0641 | 0.0585 | 0.0971 | 0.0880 | 0.6701 | 0.6175 | 0.0057 | 0.0047 | 0.0093 | 0.0061 | 0.0131 | 0.0140 | 0.0191 | 0.0201 | 0.0508 | 0.0635 | 0.0669 | 0.0793 | 0.0770 | 0.0840 | 0.1123 | 0.1231 | 0.6459 | 0.6053 | 0.0104 | 0.0106 | 0.0164 | 0.0205 | 0.0425 | 0.0614 | 0.0594 | 0.1068 | 0.6718 | |
SK-BR-3 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1275 | 136 | 348 | 1761 | 24.9 | 4.56 | 12.04 | 4.73 | 19 | 21 | 22 | 24 | 25 | 26 | 27 | 29 | 31 | 0.1550 | 273 | 0.753 | 89.14 | 19.31 | 1 | 0.6466 | 225 | 0.0917 | 1.19 | 2.649 | 0.6279 | 641.9 | 17045.4 | 465908 | 13100000 | 0.3990 | 0.2249 | 0.0000 | 0.0000 | 0.0040 | 0.0000 | 0.0283 | 0.0000 | 0.0850 | 0.0208 | 0.1377 | 0.0564 | 0.1903 | 0.0682 | 0.2510 | 0.0653 | 0.1984 | 0.1721 | 0.1053 | 0.6172 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0097 | 0.0000 | 0.0355 | 0.0145 | 0.0548 | 0.0609 | 0.0613 | 0.0522 | 0.0968 | 0.0551 | 0.2194 | 0.0725 | 0.5226 | 0.7449 | 0.0476 | 0.6250 | 0.1746 | 0.2500 | 0.1270 | 0.1250 | 0.2857 | 0.0000 | 0.1746 | 0.0000 | 0.1111 | 0.0000 | 0.0794 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0056 | 0.0278 | 0.0778 | 0.0889 | 0.1611 | 0.2111 | 0.2000 | 0.1722 | 0.0556 | 7 | 7 | 9 | 11 | 11 | 13 | 14 | 16 | 18 | 0.4459 | 0.26 | 0.850 | 0.7731 | 167.2 | 2583.98 | 43505.2 | 785905 | 0.4996 | 0.1549 | 0.0715 | 0.0083 | 0.1464 | 0.0379 | 0.2230 | 0.0592 | 0.2379 | 0.0981 | 0.1747 | 0.1637 | 0.0948 | 0.2202 | 0.0349 | 0.2239 | 0.0166 | 0.1508 | 0.0000 | 0.0379 | 0.0196 | 0.0065 | 0.0267 | 0.0196 | 0.0364 | 0.0224 | 0.0756 | 0.0427 | 0.0907 | 0.0782 | 0.1307 | 0.0941 | 0.1627 | 0.1260 | 0.1956 | 0.2288 | 0.2622 | 0.3816 | 0.0611 | 0.1433 | 0.0630 | 0.1533 | 0.1183 | 0.2067 | 0.1756 | 0.1600 | 0.1584 | 0.1267 | 0.1737 | 0.1000 | 0.1317 | 0.0667 | 0.0954 | 0.0333 | 0.0229 | 0.0100 | 0.0427 | 0.0380 | 0.0617 | 0.1032 | 0.1329 | 0.1696 | 0.1459 | 0.1969 | 0.1091 | |
SK-BR-3 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 684 | 361 | 399 | 6206 | 58.4 | 9.74 | 24.73 | 66.86 | 46 | 49 | 52 | 54 | 57 | 61 | 64 | 69 | 72 | 0.1017 | 631 | 0.682 | 36.24 | 8.54 | 1 | 0.2607 | 104 | 0.0248 | 2.23 | 3.908 | 0.5277 | 3503.6 | 215851 | 13600000 | 881000000 | 0.3536 | 0.2676 | 0.0000 | 0.0000 | 0.0035 | 0.0000 | 0.0071 | 0.0000 | 0.0426 | 0.0101 | 0.0922 | 0.0628 | 0.1525 | 0.0678 | 0.1489 | 0.0653 | 0.1915 | 0.0879 | 0.3617 | 0.7060 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0028 | 0.0000 | 0.0225 | 0.0100 | 0.0535 | 0.0627 | 0.0817 | 0.0677 | 0.0789 | 0.0652 | 0.1042 | 0.0677 | 0.6563 | 0.7268 | 0.0137 | 1.0000 | 0.0000 | 0.0000 | 0.0274 | 0.0000 | 0.0822 | 0.0000 | 0.0822 | 0.0000 | 0.1781 | 0.0000 | 0.1370 | 0.0000 | 0.2055 | 0.0000 | 0.2740 | 0.0000 | 0.0053 | 0.0053 | 0.0159 | 0.0265 | 0.0635 | 0.1111 | 0.1058 | 0.0899 | 0.5767 | 5 | 6 | 7 | 8 | 9 | 10 | 13 | 18 | 40 | 0.3348 | 9.79 | 2.064 | 0.7707 | 5081.6 | 2730000 | 1940000000 | 1570000000000 | 0.6341 | 0.0846 | 0.0349 | 0.0330 | 0.1163 | 0.0366 | 0.1453 | 0.0425 | 0.1628 | 0.0837 | 0.2006 | 0.1262 | 0.1919 | 0.1498 | 0.1163 | 0.1462 | 0.0233 | 0.1686 | 0.0087 | 0.2134 | 0.0053 | 0.0181 | 0.0079 | 0.0194 | 0.0184 | 0.0148 | 0.0202 | 0.0258 | 0.0746 | 0.0523 | 0.0886 | 0.0690 | 0.0912 | 0.0800 | 0.1202 | 0.1052 | 0.5737 | 0.6155 | 0.0025 | 0.0028 | 0.0013 | 0.0000 | 0.0088 | 0.0043 | 0.0251 | 0.0256 | 0.0842 | 0.0954 | 0.1256 | 0.1439 | 0.0942 | 0.1068 | 0.1344 | 0.1296 | 0.5239 | 0.4915 | 0.0022 | 0.0098 | 0.0065 | 0.0271 | 0.0869 | 0.0912 | 0.0988 | 0.1325 | 0.5451 | |
MCF7 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 1201 | 147 | 25401 | 21792 | 80.3 | 36.47 | 7.79 | 3.16 | 47 | 51 | 55 | 60 | 67 | 79 | 95 | 111 | 130 | 0.0646 | 1407 | 0.643 | 109.48 | 22.02 | 3 | 0.0122 | 311 | 0.0238 | 1.54 | 4.339 | 0.6433 | 7784.7 | 930349 | 141000000 | 27400000000 | 0.3746 | 0.2574 | 0.0183 | 0.0041 | 0.0285 | 0.0101 | 0.0332 | 0.0165 | 0.0445 | 0.0216 | 0.0579 | 0.0307 | 0.0760 | 0.0454 | 0.0991 | 0.0645 | 0.1547 | 0.1011 | 0.4878 | 0.7059 | 0.0063 | 0.0025 | 0.0088 | 0.0051 | 0.0101 | 0.0093 | 0.0128 | 0.0127 | 0.0158 | 0.0171 | 0.0202 | 0.0254 | 0.0263 | 0.0353 | 0.0450 | 0.0545 | 0.8547 | 0.8381 | 0.0029 | 0.0096 | 0.0051 | 0.0076 | 0.0087 | 0.0135 | 0.0154 | 0.0237 | 0.0181 | 0.0317 | 0.0252 | 0.0416 | 0.0356 | 0.0590 | 0.0614 | 0.0833 | 0.8277 | 0.7300 | 0.0039 | 0.0045 | 0.0066 | 0.0106 | 0.0121 | 0.0194 | 0.0250 | 0.0402 | 0.8777 | 4 | 5 | 6 | 7 | 8 | 9 | 9 | 10 | 12 | 0.3288 | 0.54 | 1.489 | 0.7679 | 70.7 | 710.738 | 7758.34 | 90867.1 | 0.5651 | 0.1468 | 0.0276 | 0.0002 | 0.1012 | 0.0027 | 0.1830 | 0.0162 | 0.2395 | 0.0448 | 0.2232 | 0.1065 | 0.1440 | 0.1983 | 0.0622 | 0.2724 | 0.0175 | 0.2494 | 0.0018 | 0.1095 | 0.0011 | 0.0001 | 0.0095 | 0.0007 | 0.0313 | 0.0047 | 0.0743 | 0.0148 | 0.1392 | 0.0405 | 0.2209 | 0.1002 | 0.2544 | 0.1989 | 0.1985 | 0.3291 | 0.0707 | 0.3109 | 0.0837 | 0.3817 | 0.2220 | 0.3524 | 0.2715 | 0.1695 | 0.2102 | 0.0699 | 0.1317 | 0.0232 | 0.0547 | 0.0028 | 0.0218 | 0.0004 | 0.0035 | 0.0000 | 0.0010 | 0.0000 | 0.0061 | 0.0422 | 0.1149 | 0.1974 | 0.2403 | 0.2128 | 0.1308 | 0.0484 | 0.0072 | |
MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 259 | 595 | 3281 | 8845 | 537.2 | 98.78 | 47.70 | 69.98 | 406 | 455 | 487 | 513 | 535 | 555 | 578 | 608 | 681 | 0.0684 | 605 | 1.005 | 109.84 | 37.48 | 2 | 0.0884 | 290 | 0.0012 | 24.77 | 6.942 | 0.2330 | 298323.0 | 171000000 | 101000000000 | 61500000000000 | 0.4559 | 0.1915 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0076 | 0.0006 | 0.0295 | 0.0159 | 0.0565 | 0.0312 | 0.0510 | 0.0243 | 0.0674 | 0.0328 | 0.7880 | 0.8952 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0039 | 0.0006 | 0.0159 | 0.0128 | 0.0297 | 0.0253 | 0.0244 | 0.0131 | 0.0304 | 0.0186 | 0.8956 | 0.9295 | 0.0066 | 0.0137 | 0.0088 | 0.0274 | 0.0243 | 0.0959 | 0.0133 | 0.0959 | 0.0575 | 0.2055 | 0.0973 | 0.1507 | 0.0619 | 0.1096 | 0.0841 | 0.1507 | 0.6460 | 0.1507 | 0.0012 | 0.0000 | 0.0025 | 0.0204 | 0.0532 | 0.0835 | 0.0884 | 0.1070 | 0.6438 | 8 | 9 | 11 | 12 | 14 | 19 | 46 | 78 | 131 | 0.2066 | 2.60 | 3.143 | 0.7617 | 7171.8 | 1810000 | 603000000 | 239000000000 | 0.5155 | 0.1378 | 0.0352 | 0.0029 | 0.0580 | 0.0155 | 0.0890 | 0.0638 | 0.1201 | 0.0629 | 0.1532 | 0.0977 | 0.1636 | 0.1460 | 0.1822 | 0.1199 | 0.1387 | 0.1586 | 0.0600 | 0.3327 | 0.0007 | 0.0007 | 0.0014 | 0.0020 | 0.0021 | 0.0029 | 0.0064 | 0.0085 | 0.0152 | 0.0186 | 0.0258 | 0.0232 | 0.0237 | 0.0235 | 0.0488 | 0.0405 | 0.8759 | 0.8803 | 0.0017 | 0.0015 | 0.0009 | 0.0039 | 0.0064 | 0.0064 | 0.0111 | 0.0148 | 0.0273 | 0.0261 | 0.0413 | 0.0542 | 0.0388 | 0.0473 | 0.0725 | 0.0719 | 0.8001 | 0.7740 | 0.0008 | 0.0008 | 0.0035 | 0.0096 | 0.0207 | 0.0261 | 0.0337 | 0.0560 | 0.8489 | |
MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 170 | 550 | 8750 | 8424 | 502.4 | 87.96 | 41.36 | 73.23 | 382 | 421 | 449 | 477 | 504 | 533 | 561 | 587 | 616 | 0.0991 | 835 | 0.776 | 84.48 | 24.52 | 5 | 0.0277 | 242 | 0.0010 | 31.96 | 7.187 | 0.2170 | 260103.0 | 138000000 | 75400000000 | 41900000000000 | 0.4172 | 0.2234 | 0.0005 | 0.0000 | 0.0021 | 0.0000 | 0.0032 | 0.0000 | 0.0111 | 0.0005 | 0.0476 | 0.0114 | 0.0760 | 0.0187 | 0.0904 | 0.0131 | 0.1317 | 0.0244 | 0.6373 | 0.9319 | 0.0003 | 0.0000 | 0.0001 | 0.0000 | 0.0008 | 0.0000 | 0.0043 | 0.0005 | 0.0214 | 0.0113 | 0.0331 | 0.0183 | 0.0365 | 0.0119 | 0.0525 | 0.0214 | 0.8509 | 0.9367 | 0.0126 | 0.1000 | 0.0126 | 0.2000 | 0.0356 | 0.5000 | 0.0617 | 0.2000 | 0.1146 | 0.0000 | 0.1486 | 0.0000 | 0.1328 | 0.0000 | 0.1518 | 0.0000 | 0.3296 | 0.0000 | 0.0014 | 0.0023 | 0.0063 | 0.0160 | 0.0405 | 0.0657 | 0.0673 | 0.0822 | 0.7184 | 8 | 10 | 12 | 13 | 16 | 20 | 28 | 44 | 98 | 0.1584 | 2.61 | 3.052 | 0.7597 | 7073.0 | 2420000 | 1080000000 | 547000000000 | 0.6438 | 0.0750 | 0.0266 | 0.0119 | 0.0620 | 0.0252 | 0.1004 | 0.0365 | 0.1492 | 0.0697 | 0.1905 | 0.1048 | 0.1418 | 0.1287 | 0.1536 | 0.1301 | 0.0960 | 0.1858 | 0.0798 | 0.3072 | 0.0055 | 0.0063 | 0.0104 | 0.0116 | 0.0127 | 0.0137 | 0.0209 | 0.0256 | 0.0563 | 0.0460 | 0.0700 | 0.0674 | 0.0691 | 0.0593 | 0.1004 | 0.1092 | 0.6547 | 0.6608 | 0.0000 | 0.0045 | 0.0052 | 0.0037 | 0.0085 | 0.0082 | 0.0184 | 0.0231 | 0.0636 | 0.0723 | 0.0932 | 0.0835 | 0.0636 | 0.0776 | 0.1122 | 0.1148 | 0.6352 | 0.6122 | 0.0011 | 0.0038 | 0.0098 | 0.0235 | 0.0573 | 0.0742 | 0.0770 | 0.1070 | 0.6463 | |
MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1219 | 611 | 6727 | 10795 | 500.4 | 87.18 | 61.57 | 164.61 | 389 | 436 | 464 | 484 | 500 | 519 | 539 | 564 | 613 | 0.0766 | 827 | 0.887 | 151.21 | 35.90 | 4 | 0.0523 | 352 | 0.0010 | 40.11 | 7.197 | 0.1973 | 258004.0 | 137000000 | 74100000000 | 41200000000000 | 0.4599 | 0.1961 | 0.0006 | 0.0000 | 0.0008 | 0.0000 | 0.0006 | 0.0000 | 0.0061 | 0.0005 | 0.0334 | 0.0138 | 0.0743 | 0.0305 | 0.0688 | 0.0200 | 0.0981 | 0.0361 | 0.7174 | 0.8992 | 0.0003 | 0.0000 | 0.0003 | 0.0000 | 0.0002 | 0.0000 | 0.0020 | 0.0002 | 0.0203 | 0.0122 | 0.0431 | 0.0268 | 0.0321 | 0.0141 | 0.0475 | 0.0242 | 0.8540 | 0.9226 | 0.0036 | 0.0385 | 0.0109 | 0.0641 | 0.0243 | 0.0256 | 0.0510 | 0.1282 | 0.0875 | 0.2179 | 0.1179 | 0.2179 | 0.0899 | 0.1026 | 0.1118 | 0.1026 | 0.5030 | 0.1026 | 0.0015 | 0.0026 | 0.0100 | 0.0280 | 0.0665 | 0.1130 | 0.0971 | 0.1266 | 0.5546 | 5 | 5 | 7 | 8 | 9 | 10 | 12 | 20 | 145 | 0.3474 | 14.59 | 2.480 | 0.7590 | 30885.0 | 22100000 | 18100000000 | 16500000000000 | 0.6221 | 0.0747 | 0.0404 | 0.0026 | 0.1515 | 0.0289 | 0.2172 | 0.0525 | 0.2071 | 0.1732 | 0.1515 | 0.2310 | 0.1414 | 0.2047 | 0.0505 | 0.1260 | 0.0303 | 0.0866 | 0.0101 | 0.0945 | 0.0000 | 0.0006 | 0.0006 | 0.0030 | 0.0032 | 0.0024 | 0.0121 | 0.0119 | 0.0401 | 0.0351 | 0.0650 | 0.0660 | 0.0510 | 0.0463 | 0.0643 | 0.0564 | 0.7637 | 0.7784 | 0.0000 | 0.0000 | 0.0015 | 0.0015 | 0.0015 | 0.0038 | 0.0175 | 0.0215 | 0.0445 | 0.0445 | 0.0729 | 0.0722 | 0.0590 | 0.0507 | 0.0649 | 0.0753 | 0.7383 | 0.7304 | 0.0000 | 0.0014 | 0.0020 | 0.0143 | 0.0442 | 0.0626 | 0.0558 | 0.0721 | 0.7476 | |
MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 561 | 247 | 4445 | 15033 | 466.1 | 65.09 | 63.62 | 138.06 | 379 | 413 | 433 | 450 | 466 | 481 | 499 | 521 | 551 | 0.0559 | 840 | 1.186 | 46.40 | 17.49 | 1 | 0.0270 | 120 | 0.0015 | 34.76 | 6.820 | 0.2169 | 221513.0 | 107000000 | 52800000000 | 26400000000000 | 0.4116 | 0.2311 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0035 | 0.0002 | 0.0355 | 0.0137 | 0.0646 | 0.0248 | 0.0635 | 0.0142 | 0.0910 | 0.0205 | 0.7407 | 0.9266 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0020 | 0.0002 | 0.0221 | 0.0137 | 0.0368 | 0.0248 | 0.0314 | 0.0142 | 0.0456 | 0.0187 | 0.8620 | 0.9284 | 0.0110 | 1.0000 | 0.0192 | 0.0000 | 0.0219 | 0.0000 | 0.0959 | 0.0000 | 0.1479 | 0.0000 | 0.1726 | 0.0000 | 0.1397 | 0.0000 | 0.1288 | 0.0000 | 0.2630 | 0.0000 | 0.0004 | 0.0036 | 0.0085 | 0.0278 | 0.0732 | 0.0996 | 0.0961 | 0.1302 | 0.5606 | 7 | 8 | 9 | 10 | 12 | 15 | 22 | 57 | 200 | 0.2619 | 11.61 | 3.053 | 0.7574 | 23105.5 | 14100000 | 11000000000 | 10100000000000 | 0.4691 | 0.1844 | 0.0363 | 0.0081 | 0.0726 | 0.0208 | 0.0726 | 0.0728 | 0.1501 | 0.0786 | 0.1622 | 0.1110 | 0.1671 | 0.1260 | 0.1574 | 0.1191 | 0.1090 | 0.1445 | 0.0726 | 0.3191 | 0.0003 | 0.0012 | 0.0013 | 0.0030 | 0.0023 | 0.0044 | 0.0077 | 0.0094 | 0.0229 | 0.0195 | 0.0265 | 0.0301 | 0.0245 | 0.0248 | 0.0368 | 0.0387 | 0.8777 | 0.8689 | 0.0011 | 0.0000 | 0.0011 | 0.0004 | 0.0022 | 0.0024 | 0.0108 | 0.0091 | 0.0238 | 0.0234 | 0.0309 | 0.0313 | 0.0313 | 0.0317 | 0.0395 | 0.0527 | 0.8593 | 0.8490 | 0.0003 | 0.0007 | 0.0048 | 0.0104 | 0.0214 | 0.0308 | 0.0235 | 0.0443 | 0.8637 | |
MCF7 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1040 | 910 | 3585 | 10231 | 344.3 | 84.59 | 34.10 | 76.86 | 243 | 270 | 294 | 317 | 338 | 360 | 384 | 412 | 458 | 0.0777 | 795 | 0.975 | 80.16 | 26.08 | 1 | 0.0555 | 199 | 0.0010 | 48.18 | 7.091 | 0.1715 | 125705.0 | 48500000 | 19700000000 | 8380000000000 | 0.4417 | 0.2214 | 0.0005 | 0.0000 | 0.0029 | 0.0000 | 0.0058 | 0.0006 | 0.0346 | 0.0056 | 0.1029 | 0.0262 | 0.1587 | 0.0586 | 0.1640 | 0.0586 | 0.1722 | 0.0873 | 0.3583 | 0.7630 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0014 | 0.0006 | 0.0122 | 0.0029 | 0.0480 | 0.0161 | 0.0735 | 0.0365 | 0.0724 | 0.0276 | 0.0882 | 0.0419 | 0.7031 | 0.8745 | 0.0056 | 0.0041 | 0.0014 | 0.0331 | 0.0324 | 0.0455 | 0.0606 | 0.0909 | 0.1437 | 0.2066 | 0.1521 | 0.1901 | 0.1211 | 0.1116 | 0.1563 | 0.1570 | 0.3268 | 0.1612 | 0.0006 | 0.0041 | 0.0094 | 0.0241 | 0.0700 | 0.1329 | 0.0988 | 0.1424 | 0.5176 | 5 | 6 | 6 | 8 | 9 | 10 | 14 | 28 | 84 | 0.2835 | 3.77 | 2.562 | 0.7553 | 7069.4 | 2850000 | 1600000000 | 1100000000000 | 0.6411 | 0.0755 | 0.0751 | 0.0073 | 0.1503 | 0.0125 | 0.2306 | 0.0658 | 0.2098 | 0.1524 | 0.1710 | 0.1994 | 0.0984 | 0.1754 | 0.0492 | 0.1242 | 0.0130 | 0.1420 | 0.0026 | 0.1211 | 0.0063 | 0.0020 | 0.0073 | 0.0041 | 0.0078 | 0.0138 | 0.0195 | 0.0292 | 0.0640 | 0.0604 | 0.0762 | 0.0835 | 0.0703 | 0.0722 | 0.0996 | 0.1078 | 0.6489 | 0.6271 | 0.0012 | 0.0040 | 0.0030 | 0.0020 | 0.0084 | 0.0080 | 0.0247 | 0.0172 | 0.0596 | 0.0669 | 0.0915 | 0.0948 | 0.0686 | 0.0749 | 0.1113 | 0.1021 | 0.6318 | 0.6302 | 0.0027 | 0.0027 | 0.0092 | 0.0223 | 0.0566 | 0.0886 | 0.0691 | 0.1033 | 0.6455 | |
MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 372 | 900 | 5044 | 9324 | 570.5 | 98.09 | 110.30 | 193.81 | 423 | 504 | 548 | 574 | 591 | 608 | 625 | 644 | 675 | 0.0741 | 691 | 0.949 | 144.16 | 41.87 | 3 | 0.0765 | 386 | 0.0009 | 58.08 | 7.313 | 0.1858 | 335121.0 | 201000000 | 123000000000 | 76200000000000 | 0.4530 | 0.1918 | 0.0003 | 0.0000 | 0.0008 | 0.0000 | 0.0015 | 0.0002 | 0.0055 | 0.0012 | 0.0271 | 0.0139 | 0.0472 | 0.0212 | 0.0462 | 0.0133 | 0.0650 | 0.0234 | 0.8066 | 0.9268 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0002 | 0.0002 | 0.0018 | 0.0012 | 0.0148 | 0.0139 | 0.0237 | 0.0212 | 0.0189 | 0.0133 | 0.0283 | 0.0218 | 0.9121 | 0.9285 | 0.0051 | 1.0000 | 0.0204 | 0.0000 | 0.0382 | 0.0000 | 0.0789 | 0.0000 | 0.1399 | 0.0000 | 0.1527 | 0.0000 | 0.1425 | 0.0000 | 0.1552 | 0.0000 | 0.2672 | 0.0000 | 0.0006 | 0.0016 | 0.0039 | 0.0132 | 0.0319 | 0.0631 | 0.0673 | 0.0879 | 0.7304 | 13 | 15 | 17 | 20 | 24 | 37 | 65 | 143 | 347 | 0.2499 | 4.68 | 3.068 | 0.7533 | 49725.0 | 35000000 | 30000000000 | 29200000000000 | 0.6863 | 0.0611 | 0.0201 | 0.0070 | 0.0828 | 0.0120 | 0.2081 | 0.0468 | 0.1834 | 0.0807 | 0.1969 | 0.1723 | 0.1454 | 0.1912 | 0.0805 | 0.1524 | 0.0403 | 0.1404 | 0.0425 | 0.1972 | 0.0004 | 0.0022 | 0.0004 | 0.0022 | 0.0021 | 0.0065 | 0.0116 | 0.0151 | 0.0418 | 0.0391 | 0.0708 | 0.0613 | 0.0472 | 0.0459 | 0.0911 | 0.0911 | 0.7345 | 0.7368 | 0.0000 | 0.0006 | 0.0005 | 0.0006 | 0.0051 | 0.0011 | 0.0142 | 0.0146 | 0.0524 | 0.0611 | 0.0956 | 0.0952 | 0.0478 | 0.0538 | 0.0935 | 0.0947 | 0.6909 | 0.6784 | 0.0000 | 0.0000 | 0.0019 | 0.0116 | 0.0551 | 0.0811 | 0.0487 | 0.0982 | 0.7034 | |
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1205 | 176 | 372 | 2800 | 40.2 | 10.05 | 84.88 | 173.91 | 28 | 30 | 34 | 37 | 39 | 41 | 45 | 49 | 53 | 0.1139 | 319 | 0.581 | 191.64 | 52.00 | 2 | 1.5618 | 581 | 0.0086 | 8.20 | 4.933 | 0.3440 | 1713.9 | 77670.5 | 3730000 | 189000000 | 0.3953 | 0.2248 | 0.0051 | 0.0000 | 0.0154 | 0.0000 | 0.0359 | 0.0000 | 0.1333 | 0.0088 | 0.1744 | 0.0821 | 0.1897 | 0.0645 | 0.2154 | 0.1026 | 0.1333 | 0.1378 | 0.0974 | 0.6041 | 0.0036 | 0.0000 | 0.0108 | 0.0000 | 0.0108 | 0.0000 | 0.0502 | 0.0054 | 0.0681 | 0.0622 | 0.0681 | 0.0514 | 0.0968 | 0.0514 | 0.1147 | 0.0784 | 0.5771 | 0.7514 | 0.0000 | 0.0000 | 0.0357 | 0.0345 | 0.1190 | 0.0690 | 0.0238 | 0.2069 | 0.1786 | 0.1379 | 0.1667 | 0.0345 | 0.0952 | 0.2069 | 0.1548 | 0.1379 | 0.2262 | 0.1724 | 0.0056 | 0.0056 | 0.0222 | 0.0444 | 0.0778 | 0.0944 | 0.0889 | 0.1778 | 0.4833 | 15 | 17 | 19 | 21 | 23 | 27 | 32 | 79 | 241 | 0.2089 | 3.35 | 2.782 | 0.7521 | 37440.5 | 29600000 | 28700000000 | 30700000000000 | 0.7152 | 0.0493 | 0.0130 | 0.0061 | 0.1299 | 0.0242 | 0.2987 | 0.0242 | 0.1948 | 0.0848 | 0.1429 | 0.2061 | 0.0779 | 0.2485 | 0.0649 | 0.1333 | 0.0260 | 0.1455 | 0.0519 | 0.1273 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0047 | 0.0120 | 0.0126 | 0.0342 | 0.0346 | 0.0496 | 0.0362 | 0.0479 | 0.0472 | 0.0803 | 0.0849 | 0.7761 | 0.7799 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0039 | 0.0021 | 0.0138 | 0.0085 | 0.0472 | 0.0446 | 0.0591 | 0.0807 | 0.0571 | 0.0573 | 0.1004 | 0.1083 | 0.7185 | 0.6985 | 0.0000 | 0.0000 | 0.0018 | 0.0091 | 0.0453 | 0.0507 | 0.0562 | 0.0888 | 0.7482 | |
Hs 578T | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 603 | 882 | 1319 | 7737 | 66.4 | 71.59 | 51.64 | 108.03 | 33 | 34 | 36 | 37 | 38 | 40 | 42 | 54 | 179 | 0.0778 | 602 | 1.235 | 41.48 | 16.64 | 4 | 0.0819 | 108 | 0.0362 | 35.18 | 4.239 | 0.5039 | 9528.0 | 2260000 | 632000000 | 189000000000 | 0.3313 | 0.2814 | 0.0000 | 0.0369 | 0.0984 | 0.0938 | 0.3770 | 0.0966 | 0.2295 | 0.0966 | 0.2623 | 0.0909 | 0.0328 | 0.1790 | 0.0000 | 0.1932 | 0.0000 | 0.1364 | 0.0000 | 0.0767 | 0.0000 | 0.0236 | 0.0036 | 0.0599 | 0.0036 | 0.0617 | 0.0073 | 0.0617 | 0.0584 | 0.0399 | 0.0730 | 0.0690 | 0.0474 | 0.0853 | 0.0766 | 0.0853 | 0.7299 | 0.5136 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0094 | 0.0101 | 0.0657 | 0.0653 | 0.0892 | 0.1005 | 0.0469 | 0.0503 | 0.0892 | 0.0804 | 0.6995 | 0.6935 | 0.0000 | 0.0000 | 0.0000 | 0.0170 | 0.0468 | 0.0979 | 0.0511 | 0.0638 | 0.7234 | 9 | 10 | 11 | 12 | 13 | 15 | 17 | 26 | 172 | 0.2813 | 8.15 | 2.652 | 0.7496 | 14334.9 | 6050000 | 2920000000 | 1530000000000 | 0.6889 | 0.0590 | 0.0938 | 0.0063 | 0.2313 | 0.0472 | 0.2375 | 0.1824 | 0.1813 | 0.1981 | 0.1000 | 0.2390 | 0.0938 | 0.1447 | 0.0250 | 0.0755 | 0.0313 | 0.0503 | 0.0063 | 0.0566 | 0.0000 | 0.0014 | 0.0008 | 0.0007 | 0.0031 | 0.0021 | 0.0178 | 0.0192 | 0.0666 | 0.0655 | 0.0860 | 0.0734 | 0.0713 | 0.0734 | 0.0953 | 0.0962 | 0.6592 | 0.6681 | 0.0000 | 0.0000 | 0.0009 | 0.0018 | 0.0035 | 0.0018 | 0.0221 | 0.0230 | 0.0716 | 0.0718 | 0.0902 | 0.0948 | 0.0875 | 0.0902 | 0.1043 | 0.0976 | 0.6198 | 0.6188 | 0.0008 | 0.0000 | 0.0017 | 0.0215 | 0.0710 | 0.0834 | 0.0859 | 0.0983 | 0.6375 | |
MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1013 | 682 | 13732 | 29163 | 489.2 | 88.51 | 64.45 | 140.69 | 369 | 416 | 448 | 471 | 492 | 513 | 535 | 561 | 598 | 0.0441 | 1286 | 0.817 | 91.92 | 19.24 | 13 | 0.0163 | 224 | 0.0009 | 42.91 | 7.350 | 0.2018 | 247158.0 | 129000000 | 68600000000 | 37500000000000 | 0.4764 | 0.1806 | 0.0003 | 0.0000 | 0.0008 | 0.0000 | 0.0010 | 0.0002 | 0.0078 | 0.0008 | 0.0407 | 0.0122 | 0.0790 | 0.0262 | 0.0719 | 0.0181 | 0.1073 | 0.0285 | 0.6912 | 0.9139 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0001 | 0.0000 | 0.0022 | 0.0004 | 0.0199 | 0.0104 | 0.0412 | 0.0212 | 0.0321 | 0.0132 | 0.0499 | 0.0202 | 0.8544 | 0.9345 | 0.0040 | 0.0187 | 0.0103 | 0.0327 | 0.0343 | 0.0467 | 0.0623 | 0.0561 | 0.1189 | 0.1402 | 0.1320 | 0.2150 | 0.0971 | 0.1122 | 0.1223 | 0.1636 | 0.4189 | 0.2150 | 0.0010 | 0.0013 | 0.0046 | 0.0192 | 0.0608 | 0.1022 | 0.0895 | 0.1194 | 0.6020 | 6 | 7 | 9 | 10 | 11 | 13 | 21 | 61 | 192 | 0.2959 | 12.61 | 3.087 | 0.7489 | 23946.5 | 14200000 | 10300000000 | 8680000000000 | 0.5403 | 0.1285 | 0.0409 | 0.0032 | 0.1110 | 0.0290 | 0.1519 | 0.0767 | 0.1548 | 0.0965 | 0.1500 | 0.1282 | 0.1519 | 0.1650 | 0.1042 | 0.1195 | 0.0828 | 0.1232 | 0.0526 | 0.2587 | 0.0003 | 0.0007 | 0.0006 | 0.0010 | 0.0021 | 0.0026 | 0.0106 | 0.0112 | 0.0421 | 0.0350 | 0.0683 | 0.0631 | 0.0405 | 0.0400 | 0.0644 | 0.0618 | 0.7712 | 0.7846 | 0.0002 | 0.0000 | 0.0013 | 0.0008 | 0.0025 | 0.0025 | 0.0115 | 0.0135 | 0.0507 | 0.0532 | 0.0788 | 0.0824 | 0.0465 | 0.0475 | 0.0710 | 0.0731 | 0.7375 | 0.7270 | 0.0007 | 0.0010 | 0.0017 | 0.0150 | 0.0416 | 0.0733 | 0.0472 | 0.0663 | 0.7529 |