LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 5 of 15: Mean cell count and mean growth rate across biological replicate 2. - Dataset (ID:20241)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | AZD 5438 | 10.0 | uM | LJP6 | 72 | hr | 1389 | 297 | 5667 | 0.0524 | -0.2552 |
| MCF 10A | Alvocidib | 1.11 | uM | LJP6 | 72 | hr | 1694 | 299 | 11155 | 0.0269 | -0.1474 |
| MCF 10A | Alvocidib | 0.37 | uM | LJP6 | 72 | hr | 1694 | 300 | 11155 | 0.0269 | -0.1474 |
| MCF7 | CGP60474 | 10.0 | uM | LJP6 | 72 | hr | 1389 | 300 | 5667 | 0.0530 | -0.2544 |
| Hs 578T | AT-7519 | 3.33 | uM | LJP6 | 72 | hr | 765 | 300 | 3124 | 0.0960 | -0.1971 |
| Hs 578T | Foretinib | 10.0 | uM | LJP5 | 72 | hr | 765 | 302 | 3124 | 0.0967 | -0.1963 |
| MCF 10A | CGP60474 | 0.12 | uM | LJP6 | 72 | hr | 1694 | 306 | 11155 | 0.0275 | -0.1467 |
| MCF 10A | SNS-032 | 3.33 | uM | LJP6 | 72 | hr | 1694 | 308 | 11155 | 0.0276 | -0.1465 |
| MCF 10A | SNS-032 | 1.11 | uM | LJP6 | 72 | hr | 1694 | 309 | 11155 | 0.0278 | -0.1463 |
| BT-20 | GSK1059615 | 10.0 | uM | LJP6 | 72 | hr | 1334 | 312 | 3970 | 0.0786 | -0.3879 |
| MCF 10A | AT-7519 | 3.33 | uM | LJP6 | 72 | hr | 1694 | 314 | 11155 | 0.0282 | -0.1459 |
| Hs 578T | AZD7762 | 10.0 | uM | LJP6 | 72 | hr | 765 | 315 | 3124 | 0.1008 | -0.1907 |
| BT-20 | Alvocidib | 10.0 | uM | LJP6 | 72 | hr | 1334 | 317 | 3970 | 0.0798 | -0.3860 |
| Hs 578T | A443654 | 3.33 | uM | LJP6 | 72 | hr | 765 | 321 | 3124 | 0.1028 | -0.1881 |
| Hs 578T | Fedratinib | 10.0 | uM | LJP5 | 72 | hr | 765 | 321 | 3124 | 0.1028 | -0.1881 |
| Hs 578T | Withaferin A | 10.0 | uM | LJP5 | 72 | hr | 765 | 322 | 3124 | 0.1033 | -0.1875 |
| Hs 578T | Withaferin A | 10.0 | uM | LJP6 | 72 | hr | 765 | 326 | 3124 | 0.1043 | -0.1861 |
| BT-20 | CGP60474 | 10.0 | uM | LJP5 | 72 | hr | 1334 | 330 | 3970 | 0.0833 | -0.3809 |
| Hs 578T | Buparlisib | 10.0 | uM | LJP5 | 72 | hr | 765 | 331 | 3124 | 0.1059 | -0.1840 |
| MCF 10A | Alvocidib | 10.0 | uM | LJP6 | 72 | hr | 1694 | 336 | 11155 | 0.0301 | -0.1436 |
| MCF7 | CGP60474 | 10.0 | uM | LJP5 | 72 | hr | 1389 | 343 | 5667 | 0.0605 | -0.2445 |
| MCF7 | AT-7519 | 10.0 | uM | LJP6 | 72 | hr | 1389 | 344 | 5667 | 0.0607 | -0.2442 |
| Hs 578T | Geldanamycin | 10.0 | uM | LJP5 | 72 | hr | 765 | 344 | 3124 | 0.1103 | -0.1782 |
| MCF7 | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 1389 | 345 | 5667 | 0.0609 | -0.2439 |
| Hs 578T | CGP60474 | 0.04 | uM | LJP6 | 72 | hr | 765 | 346 | 3124 | 0.1110 | -0.1773 |