LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 4 of 15: Mean cell count and mean growth rate across biological replicate 1. - Dataset (ID:20240)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | WZ3105 | 0.12 | uM | LJP5 | 72 | hr | 1476 | 1234 | 3694 | 0.3342 | -0.1092 |
| SK-BR-3 | XMD11-50 | 0.12 | uM | LJP6 | 72 | hr | 1476 | 2845 | 3694 | 0.7702 | 0.6171 |
| SK-BR-3 | Y39983 | 0.12 | uM | LJP6 | 72 | hr | 1476 | 3322 | 3694 | 0.8993 | 0.8322 |
| SK-BR-3 | YM 201636 | 0.12 | uM | LJP5 | 72 | hr | 1476 | 3684 | 3694 | 0.9975 | 0.9958 |
| SK-BR-3 | ZSTK474 | 0.12 | uM | LJP6 | 72 | hr | 1476 | 2435 | 3694 | 0.6592 | 0.4322 |
| SK-BR-3 | Afatinib | 0.37 | uM | LJP6 | 72 | hr | 1476 | 1387 | 3694 | 0.3755 | -0.0405 |
| SK-BR-3 | Sigma A6730 | 0.37 | uM | LJP5 | 72 | hr | 1476 | 3176 | 3694 | 0.8598 | 0.7664 |
| SK-BR-3 | Alvocidib | 0.37 | uM | LJP6 | 72 | hr | 1476 | 1225 | 3694 | 0.3317 | -0.1134 |
| SK-BR-3 | AT-7519 | 0.37 | uM | LJP6 | 72 | hr | 1476 | 1424 | 3694 | 0.3856 | -0.0236 |
| SK-BR-3 | AZD 5438 | 0.37 | uM | LJP6 | 72 | hr | 1476 | 1940 | 3694 | 0.5252 | 0.2089 |
| SK-BR-3 | AZD-6482 | 0.37 | uM | LJP5 | 72 | hr | 1476 | 3972 | 3694 | 1.0752 | 1.1254 |
| SK-BR-3 | AZD7762 | 0.37 | uM | LJP6 | 72 | hr | 1476 | 1283 | 3694 | 0.3475 | -0.0871 |
| SK-BR-3 | AZD8055 | 0.37 | uM | LJP6 | 72 | hr | 1476 | 1474 | 3694 | 0.3991 | -0.0011 |
| SK-BR-3 | AZD8330 | 0.37 | uM | LJP5 | 72 | hr | 1476 | 2930 | 3694 | 0.7933 | 0.6556 |
| SK-BR-3 | Barasertib | 0.37 | uM | LJP5 | 72 | hr | 1476 | 1420 | 3694 | 0.3845 | -0.0254 |
| SK-BR-3 | BI-2536 | 0.37 | uM | LJP6 | 72 | hr | 1476 | 1596 | 3694 | 0.4322 | 0.0541 |
| SK-BR-3 | BMS345541 | 0.37 | uM | LJP6 | 72 | hr | 1476 | 3784 | 3694 | 1.0244 | 1.0407 |
| SK-BR-3 | SNS-032 | 0.37 | uM | LJP6 | 72 | hr | 1476 | 885 | 3694 | 0.2396 | -0.2669 |
| SK-BR-3 | GDC-0980 | 0.37 | uM | LJP5 | 72 | hr | 1476 | 1475 | 3694 | 0.3994 | -0.0006 |
| SK-BR-3 | NVP-AEW541 | 0.37 | uM | LJP5 | 72 | hr | 1476 | 4155 | 3694 | 1.1249 | 1.2080 |
| SK-BR-3 | SB590885 | 0.37 | uM | LJP5 | 72 | hr | 1476 | 4221 | 3694 | 1.1426 | 1.2376 |
| SK-BR-3 | PIK-93 | 0.37 | uM | LJP5 | 72 | hr | 1476 | 3923 | 3694 | 1.0622 | 1.1036 |
| SK-BR-3 | KIN001-043 | 0.37 | uM | LJP6 | 72 | hr | 1476 | 3120 | 3694 | 0.8446 | 0.7411 |
| SK-BR-3 | Alpelisib | 0.37 | uM | LJP5 | 72 | hr | 1476 | 2846 | 3694 | 0.7705 | 0.6177 |
| SK-BR-3 | Luminespib | 0.37 | uM | LJP5 | 72 | hr | 1476 | 1731 | 3694 | 0.4686 | 0.1147 |