PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| C32 | 10 | hr | p-JNK(T183/Y185) | -0.14121 | -1.12140 |
| RVH-421 | 10 | hr | cPARP | 0.65903 | -0.50797 |
| LOXIMVI | 10 | hr | p-AKT(S473) | 2.28950 | -0.33653 |
| MMAC-SF | 10 | hr | p27 Kip1 | 2.37620 | -1.40000 |
| C32 | 10 | hr | p-AMPK(T172) | -1.34300 | 0.31521 |
| MMAC-SF | 10 | hr | p-p90RSK(S380) | 3.90590 | -0.84569 |
| MMAC-SF | 10 | hr | Bim | 1.08630 | -1.06580 |
| C32 | 10 | hr | p-S6(S235/236) | 3.84100 | -0.76963 |
| MMAC-SF | 10 | hr | cPARP | 0.52063 | -1.60550 |
| MMAC-SF | 10 | hr | p-HSP27(S82) | 1.16770 | 0.24366 |
| MMAC-SF | 10 | hr | p-NFKB(S536) | 5.70680 | -0.05474 |
| MMAC-SF | 10 | hr | p-Histone H3(S10) | -0.15718 | -0.42123 |
| RVH-421 | 10 | hr | p-p90RSK(S380) | 3.54790 | -0.53802 |
| MMAC-SF | 10 | hr | p-JNK(T183/Y185) | 3.25310 | 0.29454 |
| MMAC-SF | 10 | hr | p-AMPK(T172) | 4.24040 | 0.28475 |
| MMAC-SF | 10 | hr | Total c-Jun | 6.82020 | 0.58623 |
| MMAC-SF | 10 | hr | p-p70S6K(T389) | 3.51470 | 0.42585 |
| C32 | 10 | hr | p-p70S6K(T389) | NaN | NaN |
| MMAC-SF | 10 | hr | p-S6(S235/236) | 4.23920 | 1.00210 |
| MMAC-SF | 10 | hr | p-cJun(S63) | 2.78730 | -0.36165 |
| MMAC-SF | 10 | hr | p-AKT(S473) | 1.59060 | -1.34520 |
| C32 | 10 | hr | p-p70S6K(T421/S424) | 1.95890 | -0.31223 |
| MMAC-SF | 10 | hr | p-mTOR(S2448) | 3.62620 | -0.44509 |
| MMAC-SF | 10 | hr | p-AKT(T308) | NaN | NaN |
| MMAC-SF | 10 | hr | p-p70S6K(T421/S424) | 3.80410 | -1.53510 |