PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| WM1552C | 24 | hr | Bim | -2.77770 | -3.72120 |
| WM1552C | 10 | hr | Bim | 0.93921 | -3.66860 |
| WM1552C | 48 | hr | p-cJun(S63) | -1.23800 | -3.28480 |
| WM1552C | 10 | hr | p-AMPK(T172) | 1.36010 | -3.12560 |
| WM1552C | 24 | hr | p-AKT(T308) | -1.49820 | -3.08970 |
| MZ7-mel | 48 | hr | p-Histone H3(S10) | 10.26000 | -2.89720 |
| COLO 858 | 5 | hr | p-HSP27(S82) | 0.20234 | -2.85020 |
| COLO 858 | 48 | hr | p-mTOR(S2448) | 6.06640 | -2.80510 |
| WM1552C | 48 | hr | Bim | 2.39580 | -2.69920 |
| SKMEL28 | 10 | hr | p-JNK(T183/Y185) | 4.18310 | -2.67100 |
| WM1552C | 10 | hr | cPARP | 1.93500 | -2.66780 |
| MMAC-SF | 48 | hr | Bim | 0.59534 | -2.65750 |
| MMAC-SF | 48 | hr | p-AKT(S473) | 1.56980 | -2.65300 |
| MMAC-SF | 48 | hr | cPARP | -0.18759 | -2.64540 |
| RVH-421 | 1 | hr | Bim | 1.78350 | -2.61950 |
| WM1552C | 48 | hr | p-AKT(S473) | -0.93725 | -2.61410 |
| RVH-421 | 10 | hr | Bim | 2.28110 | -2.60780 |
| SKMEL28 | 48 | hr | cPARP | -4.18310 | -2.59970 |
| SKMEL28 | 1 | hr | p-JNK(T183/Y185) | 3.63970 | -2.58450 |
| WM1552C | 24 | hr | p-cJun(S63) | -2.86530 | -2.56720 |
| WM1552C | 10 | hr | p-AKT(T308) | -0.66148 | -2.55460 |
| SKMEL28 | 48 | hr | p-JNK(T183/Y185) | -1.10790 | -2.54890 |
| LOXIMVI | 1 | hr | p-NFKB(S536) | 3.79430 | -2.53930 |
| WM1552C | 10 | hr | p-P38(T180/Y182) | 1.78580 | -2.49710 |
| MZ7-mel | 5 | hr | p-p90RSK(S380) | -1.65010 | -2.49340 |