PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| C32 | 10 | hr | p-P38(T180/Y182) | -1.32110 | 0.46039 |
| C32 | 10 | hr | p-HSP27(S82) | NaN | NaN |
| C32 | 10 | hr | p-NFKB(S536) | 2.62660 | -0.12647 |
| C32 | 10 | hr | Bim | -2.40770 | 0.07521 |
| C32 | 10 | hr | cPARP | -0.36970 | -0.03616 |
| C32 | 10 | hr | p-Histone H3(S10) | -1.12370 | 0.01814 |
| C32 | 10 | hr | p27 Kip1 | -2.46360 | 0.15328 |
| C32 | 24 | hr | p-p90RSK(S380) | NaN | NaN |
| C32 | 24 | hr | p-p90RSK(T573) | 1.36760 | 0.88628 |
| C32 | 24 | hr | p-AKT(T308) | -4.62320 | 0.65157 |
| C32 | 24 | hr | p-AKT(S473) | -3.68530 | 2.31110 |
| C32 | 24 | hr | p-mTOR(S2448) | NaN | NaN |
| C32 | 24 | hr | p-p70S6K(T421/S424) | 4.78250 | -0.01794 |
| C32 | 24 | hr | p-p70S6K(T389) | NaN | NaN |
| C32 | 24 | hr | p-S6(S235/236) | 4.76950 | -0.83978 |
| C32 | 24 | hr | p-AMPK(T172) | -3.69990 | -0.02243 |
| C32 | 24 | hr | p-JNK(T183/Y185) | -1.73310 | -0.88435 |
| C32 | 24 | hr | Total c-Jun | 4.77070 | 0.93542 |
| C32 | 24 | hr | p-cJun(S63) | NaN | NaN |
| C32 | 24 | hr | p-P38(T180/Y182) | -2.78950 | 0.70934 |
| C32 | 24 | hr | p-HSP27(S82) | NaN | NaN |
| C32 | 24 | hr | p-NFKB(S536) | -0.00147 | 0.85416 |
| C32 | 24 | hr | Bim | -5.80310 | 0.97812 |
| C32 | 24 | hr | cPARP | -3.12430 | -1.44320 |
| C32 | 24 | hr | p-Histone H3(S10) | 3.41060 | 0.32607 |