PLSR model loadings (pMEK and pERK excluded) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20230)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| SKMEL28 | 5 | hr | cPARP | -2.50520 | 1.72360 |
| SKMEL28 | 5 | hr | p-Histone H3(S10) | -0.72467 | 0.29054 |
| SKMEL28 | 5 | hr | p27 Kip1 | -1.59450 | 1.26620 |
| SKMEL28 | 10 | hr | p-p90RSK(S380) | 4.94460 | 0.64712 |
| SKMEL28 | 10 | hr | p-p90RSK(T573) | 2.64040 | 1.13670 |
| SKMEL28 | 10 | hr | p-AKT(T308) | NaN | NaN |
| SKMEL28 | 10 | hr | p-AKT(S473) | 2.22460 | -2.17770 |
| SKMEL28 | 10 | hr | p-mTOR(S2448) | 3.79380 | -1.23210 |
| SKMEL28 | 10 | hr | p-p70S6K(T421/S424) | 4.37160 | -1.67730 |
| SKMEL28 | 10 | hr | p-p70S6K(T389) | 4.69400 | -0.28254 |
| SKMEL28 | 10 | hr | p-S6(S235/236) | 4.65390 | -0.40465 |
| SKMEL28 | 10 | hr | p-AMPK(T172) | 2.23410 | -1.03370 |
| SKMEL28 | 10 | hr | p-JNK(T183/Y185) | 4.18310 | -2.67100 |
| SKMEL28 | 10 | hr | Total c-Jun | 5.86060 | -1.23650 |
| SKMEL28 | 10 | hr | p-cJun(S63) | 2.40050 | -1.09500 |
| SKMEL28 | 10 | hr | p-P38(T180/Y182) | 0.70490 | -0.18486 |
| SKMEL28 | 10 | hr | p-HSP27(S82) | 2.50560 | -0.22743 |
| SKMEL28 | 10 | hr | p-NFKB(S536) | 6.56290 | -0.15696 |
| SKMEL28 | 10 | hr | Bim | -0.71464 | -0.23206 |
| SKMEL28 | 10 | hr | cPARP | 1.04370 | -0.60668 |
| SKMEL28 | 10 | hr | p-Histone H3(S10) | 0.00657 | -0.16221 |
| SKMEL28 | 10 | hr | p27 Kip1 | -0.58150 | -0.12477 |
| SKMEL28 | 24 | hr | p-p90RSK(S380) | 0.75578 | -0.20083 |
| SKMEL28 | 24 | hr | p-p90RSK(T573) | -1.65620 | -0.38483 |
| SKMEL28 | 24 | hr | p-AKT(T308) | NaN | NaN |