PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| C32 | 24 | hr | Total c-Jun | 2.14860 | 0.27793 |
| C32 | 24 | hr | p-cJun(S63) | NaN | NaN |
| C32 | 24 | hr | p-P38(T180/Y182) | -0.44669 | -0.35557 |
| C32 | 24 | hr | p-HSP27(S82) | NaN | NaN |
| C32 | 24 | hr | p-NFKB(S536) | -0.01167 | 0.16167 |
| C32 | 24 | hr | Bim | -2.02430 | 0.17281 |
| C32 | 24 | hr | cPARP | -1.00750 | -0.48375 |
| C32 | 24 | hr | p-Histone H3(S10) | 2.85950 | 0.65072 |
| C32 | 24 | hr | p27 Kip1 | -1.94430 | -0.62753 |
| C32 | 48 | hr | pMEK(S217/221) | 1.37580 | -1.14670 |
| C32 | 48 | hr | pERK(T202/Y204) | 4.11050 | -0.09046 |
| C32 | 48 | hr | p-p90RSK(S380) | NaN | NaN |
| C32 | 48 | hr | p-p90RSK(T573) | -0.23117 | -1.26180 |
| C32 | 48 | hr | p-AKT(T308) | -1.38240 | -0.71257 |
| C32 | 48 | hr | p-AKT(S473) | -0.06169 | 0.24372 |
| C32 | 48 | hr | p-mTOR(S2448) | NaN | NaN |
| C32 | 48 | hr | p-p70S6K(T421/S424) | 1.45920 | 0.03585 |
| C32 | 48 | hr | p-p70S6K(T389) | NaN | NaN |
| C32 | 48 | hr | p-S6(S235/236) | 2.80110 | 0.52063 |
| C32 | 48 | hr | p-AMPK(T172) | -2.48460 | -0.50713 |
| C32 | 48 | hr | p-JNK(T183/Y185) | -0.21890 | -0.72903 |
| C32 | 48 | hr | Total c-Jun | 0.28580 | 0.66921 |
| C32 | 48 | hr | p-cJun(S63) | NaN | NaN |
| C32 | 48 | hr | p-P38(T180/Y182) | -0.73956 | -0.55135 |
| C32 | 48 | hr | p-HSP27(S82) | NaN | NaN |