PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| SKMEL28 | 1 | hr | p-HSP27(S82) | 0.50815 | 0.77750 |
| SKMEL28 | 1 | hr | p-NFKB(S536) | 0.61372 | 0.33498 |
| SKMEL28 | 1 | hr | Bim | 0.62998 | 0.20805 |
| SKMEL28 | 1 | hr | cPARP | 0.54425 | 0.18962 |
| SKMEL28 | 1 | hr | p-Histone H3(S10) | 1.66550 | -0.35407 |
| SKMEL28 | 1 | hr | p27 Kip1 | 0.39222 | 0.39457 |
| SKMEL28 | 5 | hr | pMEK(S217/221) | 3.43520 | -2.98760 |
| SKMEL28 | 5 | hr | pERK(T202/Y204) | 10.72100 | 1.31280 |
| SKMEL28 | 5 | hr | p-p90RSK(S380) | 0.24433 | 0.96960 |
| SKMEL28 | 5 | hr | p-p90RSK(T573) | -1.32600 | 1.41600 |
| SKMEL28 | 5 | hr | p-AKT(T308) | NaN | NaN |
| SKMEL28 | 5 | hr | p-AKT(S473) | -1.23880 | 0.44288 |
| SKMEL28 | 5 | hr | p-mTOR(S2448) | -0.59978 | 0.45124 |
| SKMEL28 | 5 | hr | p-p70S6K(T421/S424) | -0.37673 | 0.49649 |
| SKMEL28 | 5 | hr | p-p70S6K(T389) | -0.04117 | 0.25238 |
| SKMEL28 | 5 | hr | p-S6(S235/236) | 2.05360 | 0.20856 |
| SKMEL28 | 5 | hr | p-AMPK(T172) | -1.59980 | 0.81396 |
| SKMEL28 | 5 | hr | p-JNK(T183/Y185) | -0.43861 | 0.31537 |
| SKMEL28 | 5 | hr | Total c-Jun | 0.41881 | 0.26760 |
| SKMEL28 | 5 | hr | p-cJun(S63) | -0.93843 | 0.67223 |
| SKMEL28 | 5 | hr | p-P38(T180/Y182) | -1.64340 | 1.19520 |
| SKMEL28 | 5 | hr | p-HSP27(S82) | -1.01040 | 0.71657 |
| SKMEL28 | 5 | hr | p-NFKB(S536) | -0.42089 | 0.74360 |
| SKMEL28 | 5 | hr | Bim | -1.79160 | 0.65481 |
| SKMEL28 | 5 | hr | cPARP | -0.84854 | 0.43649 |