PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| K2 | 48 | hr | p-mTOR(S2448) | -0.77565 | 0.17073 |
| K2 | 48 | hr | p-p70S6K(T421/S424) | -1.50260 | -0.34102 |
| K2 | 48 | hr | p-p70S6K(T389) | -0.50446 | -0.02805 |
| K2 | 48 | hr | p-S6(S235/236) | 3.03990 | 0.13259 |
| K2 | 48 | hr | p-AMPK(T172) | -2.08180 | -0.52141 |
| K2 | 48 | hr | p-JNK(T183/Y185) | -2.87780 | -0.40828 |
| K2 | 48 | hr | Total c-Jun | -3.83090 | -0.22865 |
| K2 | 48 | hr | p-cJun(S63) | -4.05810 | -0.20309 |
| K2 | 48 | hr | p-P38(T180/Y182) | -3.22150 | -0.71935 |
| K2 | 48 | hr | p-HSP27(S82) | -4.28960 | -0.14295 |
| K2 | 48 | hr | p-NFKB(S536) | -2.68750 | -0.45045 |
| K2 | 48 | hr | Bim | -5.80920 | -0.89063 |
| K2 | 48 | hr | cPARP | -3.56130 | -0.67331 |
| K2 | 48 | hr | p-Histone H3(S10) | 8.10740 | 1.35250 |
| K2 | 48 | hr | p27 Kip1 | -6.35540 | -1.17370 |
| LOXIMVI | 1 | hr | pMEK(S217/221) | 1.90140 | -5.11530 |
| LOXIMVI | 1 | hr | pERK(T202/Y204) | 4.84600 | -3.07470 |
| LOXIMVI | 1 | hr | p-p90RSK(S380) | 0.74791 | -0.35953 |
| LOXIMVI | 1 | hr | p-p90RSK(T573) | 0.65761 | -0.21995 |
| LOXIMVI | 1 | hr | p-AKT(T308) | NaN | NaN |
| LOXIMVI | 1 | hr | p-AKT(S473) | 0.43841 | 0.52891 |
| LOXIMVI | 1 | hr | p-mTOR(S2448) | 1.11660 | -0.51846 |
| LOXIMVI | 1 | hr | p-p70S6K(T421/S424) | 2.16880 | -0.97852 |
| LOXIMVI | 1 | hr | p-p70S6K(T389) | 1.95300 | -0.53050 |
| LOXIMVI | 1 | hr | p-S6(S235/236) | 0.28868 | -0.49513 |