PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| RVH-421 | 48 | hr | pMEK(S217/221) | 5.64600 | -2.20290 |
| RVH-421 | 24 | hr | pMEK(S217/221) | 3.15880 | -2.18250 |
| RVH-421 | 48 | hr | pERK(T202/Y204) | 9.55160 | -2.13990 |
| RVH-421 | 5 | hr | pMEK(S217/221) | 3.00250 | -2.02300 |
| MMAC-SF | 5 | hr | pMEK(S217/221) | 2.07790 | -1.98240 |
| LOXIMVI | 10 | hr | pERK(T202/Y204) | 4.80110 | -1.91990 |
| COLO 858 | 24 | hr | pERK(T202/Y204) | 5.07030 | -1.90490 |
| MZ7-mel | 1 | hr | pMEK(S217/221) | 3.65630 | -1.83970 |
| RVH-421 | 5 | hr | p-NFKB(S536) | -2.44820 | -1.80680 |
| WM1552C | 10 | hr | p-AKT(T308) | -0.45227 | -1.80160 |
| LOXIMVI | 48 | hr | pERK(T202/Y204) | 1.87120 | -1.79890 |
| WM1552C | 24 | hr | Bim | -1.52830 | -1.75270 |
| WM1552C | 10 | hr | Bim | 0.15272 | -1.73580 |
| COLO 858 | 48 | hr | p27 Kip1 | -2.54430 | -1.72260 |
| COLO 858 | 48 | hr | Bim | 0.76269 | -1.67370 |
| RVH-421 | 1 | hr | p-Histone H3(S10) | 2.19800 | -1.62730 |
| WM1552C | 10 | hr | pMEK(S217/221) | 3.50460 | -1.59200 |
| COLO 858 | 5 | hr | Bim | -2.56010 | -1.58120 |
| WM1552C | 1 | hr | pMEK(S217/221) | 3.84420 | -1.55640 |
| RVH-421 | 5 | hr | p-Histone H3(S10) | -3.28910 | -1.52710 |
| COLO 858 | 48 | hr | p-mTOR(S2448) | 2.68940 | -1.52560 |
| RVH-421 | 24 | hr | p27 Kip1 | -3.81390 | -1.51440 |
| RVH-421 | 48 | hr | p-S6(S235/236) | 2.99300 | -1.48290 |
| RVH-421 | 5 | hr | Bim | -1.93750 | -1.47170 |
| WM1552C | 10 | hr | p-AKT(S473) | -0.14843 | -1.44760 |