PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| WM1552C | 5 | hr | p-AKT(S473) | -0.90432 | -0.67135 |
| MZ7-mel | 48 | hr | p-Histone H3(S10) | 8.05000 | -0.66270 |
| MZ7-mel | 5 | hr | p27 Kip1 | -0.65100 | -0.65674 |
| WM1552C | 48 | hr | p27 Kip1 | 1.52600 | -0.65452 |
| MZ7-mel | 24 | hr | p-p90RSK(S380) | -0.22683 | -0.65404 |
| WM1552C | 24 | hr | p-p90RSK(T573) | -0.20617 | -0.65355 |
| LOXIMVI | 48 | hr | p-p70S6K(T421/S424) | 1.06240 | -0.65301 |
| WM1552C | 1 | hr | p-p90RSK(S380) | 1.04430 | -0.65084 |
| MZ7-mel | 5 | hr | p-NFKB(S536) | -0.36757 | -0.64203 |
| MZ7-mel | 5 | hr | p-Histone H3(S10) | -1.16230 | -0.64056 |
| WM-115 | 24 | hr | p-S6(S235/236) | 3.44150 | -0.63741 |
| SKMEL28 | 1 | hr | p-S6(S235/236) | 2.04760 | -0.63674 |
| MMAC-SF | 24 | hr | cPARP | -3.04780 | -0.63563 |
| COLO 858 | 24 | hr | p-AMPK(T172) | -0.57698 | -0.62992 |
| WM1552C | 24 | hr | p-mTOR(S2448) | 0.34390 | -0.62883 |
| C32 | 24 | hr | p27 Kip1 | -1.94430 | -0.62753 |
| COLO 858 | 24 | hr | p-p90RSK(T573) | -0.52574 | -0.62227 |
| MMAC-SF | 10 | hr | cPARP | 0.13707 | -0.61833 |
| MMAC-SF | 10 | hr | p-cJun(S63) | 1.25820 | -0.61620 |
| MZ7-mel | 5 | hr | p-mTOR(S2448) | -0.44300 | -0.61417 |
| RVH-421 | 48 | hr | p-mTOR(S2448) | -0.47362 | -0.61351 |
| WM1552C | 10 | hr | p27 Kip1 | 2.16970 | -0.61342 |
| MMAC-SF | 1 | hr | p-AKT(S473) | 0.80356 | -0.61230 |
| SKMEL28 | 1 | hr | p-JNK(T183/Y185) | 1.41030 | -0.60949 |
| WM1552C | 10 | hr | Total c-Jun | 3.25640 | -0.60574 |