PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| COLO 858 | 24 | hr | p-AKT(T308) | -3.39600 | -0.51217 |
| RVH-421 | 5 | hr | p-Histone H3(S10) | -3.28910 | -1.52710 |
| K2 | 48 | hr | p-P38(T180/Y182) | -3.22150 | -0.71935 |
| SKMEL28 | 48 | hr | Bim | -3.11680 | -0.99508 |
| MMAC-SF | 24 | hr | cPARP | -3.04780 | -0.63563 |
| RVH-421 | 24 | hr | p-NFKB(S536) | -3.03370 | -1.27460 |
| COLO 858 | 5 | hr | p-AKT(S473) | -3.01000 | -1.17560 |
| COLO 858 | 24 | hr | p-AKT(S473) | -2.96270 | -0.36599 |
| K2 | 24 | hr | cPARP | -2.92570 | -0.26219 |
| C32 | 48 | hr | cPARP | -2.89870 | -1.43150 |
| MMAC-SF | 24 | hr | p-cJun(S63) | -2.88630 | 0.01569 |
| K2 | 48 | hr | p-JNK(T183/Y185) | -2.87780 | -0.40828 |
| K2 | 24 | hr | p-HSP27(S82) | -2.77680 | 0.17225 |
| RVH-421 | 48 | hr | p27 Kip1 | -2.77630 | -1.08590 |
| SKMEL28 | 24 | hr | p27 Kip1 | -2.71340 | -0.44041 |
| MZ7-mel | 24 | hr | Bim | -2.69420 | -0.86827 |
| K2 | 48 | hr | p-NFKB(S536) | -2.68750 | -0.45045 |
| C32 | 48 | hr | Bim | -2.68240 | -0.47847 |
| MMAC-SF | 24 | hr | p-AKT(S473) | -2.66610 | 0.08923 |
| MMAC-SF | 24 | hr | p-HSP27(S82) | -2.65220 | 0.12816 |
| COLO 858 | 24 | hr | p-JNK(T183/Y185) | -2.60770 | -0.69431 |
| SKMEL28 | 24 | hr | p-P38(T180/Y182) | -2.60370 | -0.31292 |
| COLO 858 | 5 | hr | Bim | -2.56010 | -1.58120 |
| COLO 858 | 48 | hr | p27 Kip1 | -2.54430 | -1.72260 |
| RVH-421 | 10 | hr | Total c-Jun | -2.50660 | 1.53710 |