PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| WM-115 | 5 | hr | p-JNK(T183/Y185) | -0.60147 | 0.93064 |
| SKMEL28 | 5 | hr | p-mTOR(S2448) | -0.59978 | 0.45124 |
| WM1552C | 5 | hr | p-p70S6K(T389) | -0.59739 | -0.86903 |
| MZ7-mel | 5 | hr | p-AKT(T308) | -0.59428 | -0.77035 |
| MMAC-SF | 24 | hr | p-p90RSK(S380) | -0.59234 | 0.22698 |
| C32 | 1 | hr | p-Histone H3(S10) | -0.59038 | 0.58833 |
| SKMEL28 | 24 | hr | p-cJun(S63) | -0.57728 | 0.12976 |
| COLO 858 | 24 | hr | p-AMPK(T172) | -0.57698 | -0.62992 |
| C32 | 5 | hr | p-AMPK(T172) | -0.53619 | -0.09893 |
| WM-115 | 24 | hr | p-p70S6K(T421/S424) | -0.52820 | 0.44946 |
| COLO 858 | 24 | hr | p-p90RSK(T573) | -0.52574 | -0.62227 |
| RVH-421 | 24 | hr | p-cJun(S63) | -0.52074 | 0.20948 |
| WM1552C | 5 | hr | p-NFKB(S536) | -0.51668 | -0.58352 |
| C32 | 10 | hr | p-AKT(T308) | -0.51487 | -0.10240 |
| C32 | 5 | hr | p-p90RSK(T573) | -0.50929 | -0.16568 |
| K2 | 48 | hr | p-p70S6K(T389) | -0.50446 | -0.02805 |
| WM-115 | 24 | hr | p-mTOR(S2448) | -0.49535 | 1.31540 |
| K2 | 5 | hr | p-p70S6K(T421/S424) | -0.49141 | 0.09269 |
| K2 | 5 | hr | p-P38(T180/Y182) | -0.48809 | -0.15335 |
| WM1552C | 5 | hr | p-p70S6K(T421/S424) | -0.48323 | -1.20100 |
| COLO 858 | 5 | hr | p-P38(T180/Y182) | -0.47735 | 0.95568 |
| RVH-421 | 48 | hr | p-mTOR(S2448) | -0.47362 | -0.61351 |
| MZ7-mel | 24 | hr | p-AKT(S473) | -0.46861 | -0.51382 |
| MZ7-mel | 24 | hr | p-mTOR(S2448) | -0.46399 | -0.35294 |
| WM-115 | 24 | hr | p-P38(T180/Y182) | -0.46087 | 0.41602 |