PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| WM-115 | 48 | hr | pERK(T202/Y204) | 7.75390 | 0.06613 |
| WM-115 | 48 | hr | p-p90RSK(S380) | 1.24730 | 0.90426 |
| WM-115 | 48 | hr | p-p90RSK(T573) | 1.45250 | 1.12410 |
| WM-115 | 48 | hr | p-AKT(T308) | -1.09010 | 0.72651 |
| WM-115 | 48 | hr | p-AKT(S473) | -0.66683 | 1.18370 |
| WM-115 | 48 | hr | p-mTOR(S2448) | 0.35394 | 1.87710 |
| WM-115 | 48 | hr | p-p70S6K(T421/S424) | 1.94760 | 1.13980 |
| WM-115 | 48 | hr | p-p70S6K(T389) | 0.91259 | 1.76960 |
| WM-115 | 48 | hr | p-S6(S235/236) | 3.67830 | -0.76412 |
| WM-115 | 48 | hr | p-AMPK(T172) | -1.43820 | 1.36840 |
| WM-115 | 48 | hr | p-JNK(T183/Y185) | 0.22576 | 1.12860 |
| WM-115 | 48 | hr | Total c-Jun | -4.44870 | 1.66170 |
| WM-115 | 48 | hr | p-cJun(S63) | -2.22690 | 2.11010 |
| WM-115 | 48 | hr | p-P38(T180/Y182) | 0.90801 | 1.32400 |
| WM-115 | 48 | hr | p-HSP27(S82) | 0.05554 | 1.17470 |
| WM-115 | 48 | hr | p-NFKB(S536) | 0.60937 | 1.58980 |
| WM-115 | 48 | hr | Bim | -2.06930 | 1.42830 |
| WM-115 | 48 | hr | cPARP | -1.52470 | 0.42378 |
| WM-115 | 48 | hr | p-Histone H3(S10) | 6.78360 | 1.83760 |
| WM-115 | 48 | hr | p27 Kip1 | -2.03720 | 1.38570 |
| WM1552C | 1 | hr | pMEK(S217/221) | 3.84420 | -1.55640 |
| WM1552C | 1 | hr | pERK(T202/Y204) | 9.39050 | 0.68225 |
| WM1552C | 1 | hr | p-p90RSK(S380) | 1.04430 | -0.65084 |
| WM1552C | 1 | hr | p-p90RSK(T573) | 0.97504 | -0.48370 |
| WM1552C | 1 | hr | p-AKT(T308) | 0.96300 | -1.16030 |