PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| WM-115 | 5 | hr | p-P38(T180/Y182) | 0.11276 | 0.16637 |
| WM-115 | 5 | hr | p-HSP27(S82) | 0.02344 | 0.26354 |
| WM-115 | 5 | hr | p-NFKB(S536) | -0.20464 | 0.48328 |
| WM-115 | 5 | hr | Bim | -1.45460 | 1.18970 |
| WM-115 | 5 | hr | cPARP | -0.24793 | 0.29727 |
| WM-115 | 5 | hr | p-Histone H3(S10) | -2.26140 | 0.74478 |
| WM-115 | 5 | hr | p27 Kip1 | -0.06108 | 0.51786 |
| WM-115 | 10 | hr | pMEK(S217/221) | 3.65410 | -0.16640 |
| WM-115 | 10 | hr | pERK(T202/Y204) | 5.04500 | -0.47106 |
| WM-115 | 10 | hr | p-p90RSK(S380) | 1.03130 | 0.12859 |
| WM-115 | 10 | hr | p-p90RSK(T573) | -0.01965 | 0.22543 |
| WM-115 | 10 | hr | p-AKT(T308) | -0.93077 | 1.60530 |
| WM-115 | 10 | hr | p-AKT(S473) | -1.28700 | 1.18890 |
| WM-115 | 10 | hr | p-mTOR(S2448) | 0.26044 | 0.80667 |
| WM-115 | 10 | hr | p-p70S6K(T421/S424) | 0.47619 | 0.53291 |
| WM-115 | 10 | hr | p-p70S6K(T389) | 0.87038 | 0.96586 |
| WM-115 | 10 | hr | p-S6(S235/236) | 1.83330 | -0.43886 |
| WM-115 | 10 | hr | p-AMPK(T172) | 0.25548 | 0.64474 |
| WM-115 | 10 | hr | p-JNK(T183/Y185) | 0.48886 | 0.86935 |
| WM-115 | 10 | hr | Total c-Jun | -0.78471 | -0.43368 |
| WM-115 | 10 | hr | p-cJun(S63) | 0.00943 | 1.19780 |
| WM-115 | 10 | hr | p-P38(T180/Y182) | 0.23569 | 0.16682 |
| WM-115 | 10 | hr | p-HSP27(S82) | -0.30671 | 0.21140 |
| WM-115 | 10 | hr | p-NFKB(S536) | 0.17229 | 0.55414 |
| WM-115 | 10 | hr | Bim | -0.37190 | 1.31750 |