Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| JNK-IN-8 | WM1552C | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 204.00 | p-Rb(S807/S811) | 111.59 | p-S6(S235/S236 | 385.25 | 2 | WM1552C-signal2 | E4 | |
| JNK-IN-8 | WM1552C | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 238.67 | p-Rb(S807/S811) | 112.35 | p-S6(S235/S236 | 403.49 | 2 | WM1552C-signal2 | E5 | |
| JNK-IN-8 | WM1552C | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 233.60 | p-Rb(S807/S811) | 115.43 | p-S6(S235/S236 | 404.08 | 2 | WM1552C-signal2 | E6 | |
| JNK-IN-8 | WM1552C | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 202.01 | p-Rb(S807/S811) | 113.23 | p-S6(S235/S236 | 403.64 | 2 | WM1552C-signal2 | E7 | |
| JNK-IN-8 | WM1552C | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 205.45 | p-Rb(S807/S811) | 114.75 | p-S6(S235/S236 | 404.26 | 2 | WM1552C-signal2 | E8 | |
| JNK-IN-8 | WM1552C | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 179.59 | p-Rb(S807/S811) | 113.28 | p-S6(S235/S236 | 408.38 | 2 | WM1552C-signal2 | E9 | |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 210.57 | p-Rb(S807/S811) | 110.35 | p-S6(S235/S236 | 439.65 | 2 | WM1552C-signal2 | G10 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 277.62 | p-Rb(S807/S811) | 113.74 | p-S6(S235/S236 | 415.75 | 2 | WM1552C-signal2 | G11 |
| Vemurafenib | WM1552C | JNK-IN-8 | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 199.56 | p-Rb(S807/S811) | 57.27 | p-S6(S235/S236 | 29.25 | 2 | WM1552C-signal2 | G2 |
| Vemurafenib | WM1552C | JNK-IN-8 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 146.05 | p-Rb(S807/S811) | 52.87 | p-S6(S235/S236 | 247.44 | 2 | WM1552C-signal2 | G3 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 177.34 | p-Rb(S807/S811) | 61.94 | p-S6(S235/S236 | 398.32 | 2 | WM1552C-signal2 | G4 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 158.64 | p-Rb(S807/S811) | 76.31 | p-S6(S235/S236 | 405.08 | 2 | WM1552C-signal2 | G5 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 232.69 | p-Rb(S807/S811) | 95.77 | p-S6(S235/S236 | 414.55 | 2 | WM1552C-signal2 | G6 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 191.70 | p-Rb(S807/S811) | 97.70 | p-S6(S235/S236 | 403.09 | 2 | WM1552C-signal2 | G7 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 197.88 | p-Rb(S807/S811) | 110.31 | p-S6(S235/S236 | 410.75 | 2 | WM1552C-signal2 | G8 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 215.02 | p-Rb(S807/S811) | 116.21 | p-S6(S235/S236 | 424.78 | 2 | WM1552C-signal2 | G9 |
| Vemurafenib | WM1552C | 0.0033 | uM | 24 | hr | | Ki-67 | 1609.30 | p-Rb(S807/S811) | 102.99 | p-cJun(S73) | 143.15 | 2 | WM1552C-signal3 | C10 | |
| Vemurafenib | WM1552C | 0.0000 | uM | 24 | hr | | Ki-67 | 1637.30 | p-Rb(S807/S811) | 105.15 | p-cJun(S73) | 139.30 | 2 | WM1552C-signal3 | C11 | |
| Vemurafenib | WM1552C | 5.0000 | uM | 24 | hr | | Ki-67 | 955.89 | p-Rb(S807/S811) | 49.08 | p-cJun(S73) | 59.90 | 2 | WM1552C-signal3 | C2 | |
| Vemurafenib | WM1552C | 2.0000 | uM | 24 | hr | | Ki-67 | 885.89 | p-Rb(S807/S811) | 44.19 | p-cJun(S73) | 99.31 | 2 | WM1552C-signal3 | C3 | |
| Vemurafenib | WM1552C | 0.8000 | uM | 24 | hr | | Ki-67 | 1017.40 | p-Rb(S807/S811) | 54.97 | p-cJun(S73) | 137.70 | 2 | WM1552C-signal3 | C4 | |
| Vemurafenib | WM1552C | 0.3200 | uM | 24 | hr | | Ki-67 | 1222.80 | p-Rb(S807/S811) | 74.23 | p-cJun(S73) | 158.69 | 2 | WM1552C-signal3 | C5 | |
| Vemurafenib | WM1552C | 0.1280 | uM | 24 | hr | | Ki-67 | 1348.40 | p-Rb(S807/S811) | 86.19 | p-cJun(S73) | 162.31 | 2 | WM1552C-signal3 | C6 | |
| Vemurafenib | WM1552C | 0.0512 | uM | 24 | hr | | Ki-67 | 1417.80 | p-Rb(S807/S811) | 90.84 | p-cJun(S73) | 153.01 | 2 | WM1552C-signal3 | C7 | |
| Vemurafenib | WM1552C | 0.0205 | uM | 24 | hr | | Ki-67 | 1578.70 | p-Rb(S807/S811) | 105.13 | p-cJun(S73) | 151.66 | 2 | WM1552C-signal3 | C8 |