Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| JNK-IN-8 | LOXIMVI | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 254.16 | p-Rb(S807/S811) | 231.99 | p-S6(S235/S236 | 458.18 | 2 | LOXIMVI-signal2 | E9 | |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 300.97 | p-Rb(S807/S811) | 216.71 | p-S6(S235/S236 | 433.18 | 2 | LOXIMVI-signal2 | G10 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 325.81 | p-Rb(S807/S811) | 222.34 | p-S6(S235/S236 | 438.90 | 2 | LOXIMVI-signal2 | G11 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 351.16 | p-Rb(S807/S811) | 100.40 | p-S6(S235/S236 | 22.18 | 2 | LOXIMVI-signal2 | G2 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 231.93 | p-Rb(S807/S811) | 91.17 | p-S6(S235/S236 | 89.76 | 2 | LOXIMVI-signal2 | G3 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 258.89 | p-Rb(S807/S811) | 123.29 | p-S6(S235/S236 | 272.97 | 2 | LOXIMVI-signal2 | G4 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 233.71 | p-Rb(S807/S811) | 136.67 | p-S6(S235/S236 | 375.36 | 2 | LOXIMVI-signal2 | G5 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 268.49 | p-Rb(S807/S811) | 170.62 | p-S6(S235/S236 | 412.34 | 2 | LOXIMVI-signal2 | G6 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 230.14 | p-Rb(S807/S811) | 187.63 | p-S6(S235/S236 | 409.48 | 2 | LOXIMVI-signal2 | G7 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 258.76 | p-Rb(S807/S811) | 210.04 | p-S6(S235/S236 | 429.29 | 2 | LOXIMVI-signal2 | G8 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 260.82 | p-Rb(S807/S811) | 220.20 | p-S6(S235/S236 | 459.82 | 2 | LOXIMVI-signal2 | G9 |
| Vemurafenib | LOXIMVI | 0.0033 | uM | 24 | hr | | Ki-67 | 2960.60 | p-Rb(S807/S811) | 197.88 | p-cJun(S73) | 114.95 | 2 | LOXIMVI-signal3 | C10 | |
| Vemurafenib | LOXIMVI | 0.0000 | uM | 24 | hr | | Ki-67 | 3001.50 | p-Rb(S807/S811) | 195.98 | p-cJun(S73) | 118.37 | 2 | LOXIMVI-signal3 | C11 | |
| Vemurafenib | LOXIMVI | 5.0000 | uM | 24 | hr | | Ki-67 | 1979.00 | p-Rb(S807/S811) | 73.51 | p-cJun(S73) | 77.14 | 2 | LOXIMVI-signal3 | C2 | |
| Vemurafenib | LOXIMVI | 2.0000 | uM | 24 | hr | | Ki-67 | 2153.30 | p-Rb(S807/S811) | 92.72 | p-cJun(S73) | 84.91 | 2 | LOXIMVI-signal3 | C3 | |
| Vemurafenib | LOXIMVI | 0.8000 | uM | 24 | hr | | Ki-67 | 2448.30 | p-Rb(S807/S811) | 126.79 | p-cJun(S73) | 81.56 | 2 | LOXIMVI-signal3 | C4 | |
| Vemurafenib | LOXIMVI | 0.3200 | uM | 24 | hr | | Ki-67 | 2387.10 | p-Rb(S807/S811) | 134.09 | p-cJun(S73) | 83.10 | 2 | LOXIMVI-signal3 | C5 | |
| Vemurafenib | LOXIMVI | 0.1280 | uM | 24 | hr | | Ki-67 | 2570.00 | p-Rb(S807/S811) | 157.19 | p-cJun(S73) | 85.99 | 2 | LOXIMVI-signal3 | C6 | |
| Vemurafenib | LOXIMVI | 0.0512 | uM | 24 | hr | | Ki-67 | 2629.00 | p-Rb(S807/S811) | 170.98 | p-cJun(S73) | 89.13 | 2 | LOXIMVI-signal3 | C7 | |
| Vemurafenib | LOXIMVI | 0.0205 | uM | 24 | hr | | Ki-67 | 2858.70 | p-Rb(S807/S811) | 191.23 | p-cJun(S73) | 102.21 | 2 | LOXIMVI-signal3 | C8 | |
| Vemurafenib | LOXIMVI | 0.0082 | uM | 24 | hr | | Ki-67 | 2983.70 | p-Rb(S807/S811) | 203.05 | p-cJun(S73) | 109.97 | 2 | LOXIMVI-signal3 | C9 | |
| JNK-IN-8 | LOXIMVI | 0.0033 | uM | 24 | hr | | Ki-67 | 2929.10 | p-Rb(S807/S811) | 208.63 | p-cJun(S73) | 107.76 | 2 | LOXIMVI-signal3 | E10 | |
| JNK-IN-8 | LOXIMVI | 0.0000 | uM | 24 | hr | | Ki-67 | 3030.30 | p-Rb(S807/S811) | 205.20 | p-cJun(S73) | 122.59 | 2 | LOXIMVI-signal3 | E11 | |
| JNK-IN-8 | LOXIMVI | 5.0000 | uM | 24 | hr | | Ki-67 | 2973.70 | p-Rb(S807/S811) | 240.23 | p-cJun(S73) | 48.04 | 2 | LOXIMVI-signal3 | E2 | |
| JNK-IN-8 | LOXIMVI | 2.0000 | uM | 24 | hr | | Ki-67 | 3091.80 | p-Rb(S807/S811) | 251.41 | p-cJun(S73) | 53.20 | 2 | LOXIMVI-signal3 | E3 |