Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | COLO 858 | JNK-IN-8 | 2.0000 | uM | 24 | hr | | Ki-67 | 1130.80 | p-Rb(S807/S811) | 51.60 | p-cJun(S73) | 14.98 | 1 | Colo858-signal3 | F3 |
| Vemurafenib | WM-115 | JNK-IN-8 | 2.0000 | uM | 24 | hr | | Ki-67 | 684.33 | p-Rb(S807/S811) | 51.01 | p-cJun(S73) | 18.52 | 1 | WM115-signal3 | F3 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 2.0000 | uM | 24 | hr | | p27 Kip1 | 1532.60 | p-Rb(S807/S811) | 62.03 | p-ERK(T202/Y204) | 22.35 | 1 | Colo858-signal1 | F3 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.8000 | uM | 24 | hr | | Ki-67 | 744.48 | p-Rb(S807/S811) | 42.82 | p-cJun(S73) | 20.07 | 1 | WM115-signal3 | F4 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 201.42 | p-Rb(S807/S811) | 39.76 | p-S6(S235/S236 | 56.51 | 1 | WM115-signal2 | F4 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 158.30 | p-Rb(S807/S811) | 60.54 | p-S6(S235/S236 | 363.25 | 1 | WM1552C-signal2 | F4 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 229.22 | p-Rb(S807/S811) | 100.85 | p-S6(S235/S236 | 225.60 | 1 | LOXIMVI-signal2 | F4 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p27 Kip1 | 428.03 | p-Rb(S807/S811) | 51.23 | p-ERK(T202/Y204) | 26.59 | 1 | WM1552C-signal1 | F4 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p27 Kip1 | 315.18 | p-Rb(S807/S811) | 43.87 | p-ERK(T202/Y204) | 29.26 | 1 | WM115-signal1 | F4 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p27 Kip1 | 1176.20 | p-Rb(S807/S811) | 47.97 | p-ERK(T202/Y204) | 25.00 | 1 | Colo858-signal1 | F4 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.8000 | uM | 24 | hr | | Ki-67 | 807.26 | p-Rb(S807/S811) | 48.49 | p-cJun(S73) | 14.54 | 1 | Colo858-signal3 | F4 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.8000 | uM | 24 | hr | | Ki-67 | 1070.90 | p-Rb(S807/S811) | 51.39 | p-cJun(S73) | 29.77 | 1 | WM1552C-signal3 | F4 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.8000 | uM | 24 | hr | | Ki-67 | 2249.30 | p-Rb(S807/S811) | 93.65 | p-cJun(S73) | 24.47 | 1 | LOXIMVI-signal3 | F4 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p27 Kip1 | 546.66 | p-Rb(S807/S811) | 87.40 | p-ERK(T202/Y204) | 40.47 | 1 | LOXIMVI-signal1 | F4 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 168.97 | p-Rb(S807/S811) | 57.67 | p-S6(S235/S236 | 47.25 | 1 | Colo858-signal2 | F4 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.3200 | uM | 24 | hr | | Ki-67 | 737.49 | p-Rb(S807/S811) | 41.43 | p-cJun(S73) | 27.30 | 1 | WM115-signal3 | F5 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 237.24 | p-Rb(S807/S811) | 135.99 | p-S6(S235/S236 | 359.46 | 1 | LOXIMVI-signal2 | F5 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 155.41 | p-Rb(S807/S811) | 59.98 | p-S6(S235/S236 | 99.31 | 1 | Colo858-signal2 | F5 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.3200 | uM | 24 | hr | | Ki-67 | 1190.30 | p-Rb(S807/S811) | 65.76 | p-cJun(S73) | 94.49 | 1 | WM1552C-signal3 | F5 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 204.23 | p-Rb(S807/S811) | 70.93 | p-S6(S235/S236 | 342.80 | 1 | WM1552C-signal2 | F5 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.3200 | uM | 24 | hr | | Ki-67 | 797.23 | p-Rb(S807/S811) | 51.78 | p-cJun(S73) | 20.45 | 1 | Colo858-signal3 | F5 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 206.61 | p-Rb(S807/S811) | 41.17 | p-S6(S235/S236 | 77.73 | 1 | WM115-signal2 | F5 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.3200 | uM | 24 | hr | | Ki-67 | 2320.10 | p-Rb(S807/S811) | 113.12 | p-cJun(S73) | 29.40 | 1 | LOXIMVI-signal3 | F5 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p27 Kip1 | 343.75 | p-Rb(S807/S811) | 67.08 | p-ERK(T202/Y204) | 51.17 | 1 | WM1552C-signal1 | F5 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p27 Kip1 | 1024.70 | p-Rb(S807/S811) | 48.87 | p-ERK(T202/Y204) | 30.22 | 1 | Colo858-signal1 | F5 |