Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| JNK-IN-8 | LOXIMVI | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 388.24 | p-Rb(S807/S811) | 277.19 | p-S6(S235/S236 | 582.84 | 1 | LOXIMVI-signal2 | D2 | |
| JNK-IN-8 | WM1552C | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 226.81 | p-Rb(S807/S811) | 116.31 | p-S6(S235/S236 | 435.53 | 1 | WM1552C-signal2 | D3 | |
| JNK-IN-8 | WM1552C | 2.0000 | uM | 24 | hr | | p27 Kip1 | 258.20 | p-Rb(S807/S811) | 113.91 | p-ERK(T202/Y204) | 277.27 | 1 | WM1552C-signal1 | D3 | |
| JNK-IN-8 | WM-115 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 238.07 | p-Rb(S807/S811) | 80.65 | p-S6(S235/S236 | 200.44 | 1 | WM115-signal2 | D3 | |
| JNK-IN-8 | COLO 858 | 2.0000 | uM | 24 | hr | | p27 Kip1 | 596.02 | p-Rb(S807/S811) | 233.59 | p-ERK(T202/Y204) | 707.32 | 1 | Colo858-signal1 | D3 | |
| JNK-IN-8 | WM-115 | 2.0000 | uM | 24 | hr | | Ki-67 | 790.07 | p-Rb(S807/S811) | 77.44 | p-cJun(S73) | 19.89 | 1 | WM115-signal3 | D3 | |
| JNK-IN-8 | LOXIMVI | 2.0000 | uM | 24 | hr | | p27 Kip1 | 376.92 | p-Rb(S807/S811) | 258.15 | p-ERK(T202/Y204) | 235.58 | 1 | LOXIMVI-signal1 | D3 | |
| JNK-IN-8 | LOXIMVI | 2.0000 | uM | 24 | hr | | Ki-67 | 3123.80 | p-Rb(S807/S811) | 257.55 | p-cJun(S73) | 54.72 | 1 | LOXIMVI-signal3 | D3 | |
| JNK-IN-8 | COLO 858 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 355.48 | p-Rb(S807/S811) | 234.13 | p-S6(S235/S236 | 567.56 | 1 | Colo858-signal2 | D3 | |
| JNK-IN-8 | WM1552C | 2.0000 | uM | 24 | hr | | Ki-67 | 1543.30 | p-Rb(S807/S811) | 112.25 | p-cJun(S73) | 28.35 | 1 | WM1552C-signal3 | D3 | |
| JNK-IN-8 | COLO 858 | 2.0000 | uM | 24 | hr | | Ki-67 | 2559.90 | p-Rb(S807/S811) | 217.09 | p-cJun(S73) | 34.91 | 1 | Colo858-signal3 | D3 | |
| JNK-IN-8 | WM-115 | 2.0000 | uM | 24 | hr | | p27 Kip1 | 254.69 | p-Rb(S807/S811) | 87.41 | p-ERK(T202/Y204) | 724.06 | 1 | WM115-signal1 | D3 | |
| JNK-IN-8 | LOXIMVI | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 368.60 | p-Rb(S807/S811) | 272.58 | p-S6(S235/S236 | 627.74 | 1 | LOXIMVI-signal2 | D3 | |
| JNK-IN-8 | WM1552C | 0.8000 | uM | 24 | hr | | p27 Kip1 | 247.69 | p-Rb(S807/S811) | 115.02 | p-ERK(T202/Y204) | 276.76 | 1 | WM1552C-signal1 | D4 | |
| JNK-IN-8 | WM-115 | 0.8000 | uM | 24 | hr | | p27 Kip1 | 243.86 | p-Rb(S807/S811) | 88.86 | p-ERK(T202/Y204) | 663.72 | 1 | WM115-signal1 | D4 | |
| JNK-IN-8 | LOXIMVI | 0.8000 | uM | 24 | hr | | p27 Kip1 | 336.96 | p-Rb(S807/S811) | 231.40 | p-ERK(T202/Y204) | 222.11 | 1 | LOXIMVI-signal1 | D4 | |
| JNK-IN-8 | COLO 858 | 0.8000 | uM | 24 | hr | | p27 Kip1 | 488.74 | p-Rb(S807/S811) | 190.14 | p-ERK(T202/Y204) | 694.83 | 1 | Colo858-signal1 | D4 | |
| JNK-IN-8 | COLO 858 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 332.96 | p-Rb(S807/S811) | 207.97 | p-S6(S235/S236 | 501.48 | 1 | Colo858-signal2 | D4 | |
| JNK-IN-8 | WM-115 | 0.8000 | uM | 24 | hr | | Ki-67 | 812.54 | p-Rb(S807/S811) | 82.01 | p-cJun(S73) | 21.32 | 1 | WM115-signal3 | D4 | |
| JNK-IN-8 | WM1552C | 0.8000 | uM | 24 | hr | | Ki-67 | 1714.80 | p-Rb(S807/S811) | 114.20 | p-cJun(S73) | 63.58 | 1 | WM1552C-signal3 | D4 | |
| JNK-IN-8 | WM1552C | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 262.28 | p-Rb(S807/S811) | 113.37 | p-S6(S235/S236 | 413.92 | 1 | WM1552C-signal2 | D4 | |
| JNK-IN-8 | COLO 858 | 0.8000 | uM | 24 | hr | | Ki-67 | 2383.20 | p-Rb(S807/S811) | 179.73 | p-cJun(S73) | 31.88 | 1 | Colo858-signal3 | D4 | |
| JNK-IN-8 | LOXIMVI | 0.8000 | uM | 24 | hr | | Ki-67 | 2971.40 | p-Rb(S807/S811) | 219.05 | p-cJun(S73) | 57.05 | 1 | LOXIMVI-signal3 | D4 | |
| JNK-IN-8 | WM-115 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 235.96 | p-Rb(S807/S811) | 79.36 | p-S6(S235/S236 | 186.75 | 1 | WM115-signal2 | D4 | |
| JNK-IN-8 | LOXIMVI | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 344.33 | p-Rb(S807/S811) | 248.42 | p-S6(S235/S236 | 524.11 | 1 | LOXIMVI-signal2 | D4 |