Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| JNK-IN-8 | WM-115 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 197.00 | p-Rb(S807/S811) | 65.37 | p-S6(S235/S236 | 186.60 | 1 | WM115-signal2 | D10 | |
| JNK-IN-8 | LOXIMVI | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 283.24 | p-Rb(S807/S811) | 237.66 | p-S6(S235/S236 | 456.10 | 1 | LOXIMVI-signal2 | D10 | |
| JNK-IN-8 | WM-115 | 0.0000 | uM | 24 | hr | | Ki-67 | 713.17 | p-Rb(S807/S811) | 74.83 | p-cJun(S73) | 48.37 | 1 | WM115-signal3 | D11 | |
| JNK-IN-8 | LOXIMVI | 0.0000 | uM | 24 | hr | | Ki-67 | 3098.40 | p-Rb(S807/S811) | 213.41 | p-cJun(S73) | 128.11 | 1 | LOXIMVI-signal3 | D11 | |
| JNK-IN-8 | COLO 858 | 0.0000 | uM | 24 | hr | | p27 Kip1 | 454.18 | p-Rb(S807/S811) | 159.65 | p-ERK(T202/Y204) | 628.56 | 1 | Colo858-signal1 | D11 | |
| JNK-IN-8 | LOXIMVI | 0.0000 | uM | 24 | hr | | p27 Kip1 | 348.21 | p-Rb(S807/S811) | 217.92 | p-ERK(T202/Y204) | 232.50 | 1 | LOXIMVI-signal1 | D11 | |
| JNK-IN-8 | WM1552C | 0.0000 | uM | 24 | hr | | p27 Kip1 | 244.30 | p-Rb(S807/S811) | 104.67 | p-ERK(T202/Y204) | 252.82 | 1 | WM1552C-signal1 | D11 | |
| JNK-IN-8 | COLO 858 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 323.83 | p-Rb(S807/S811) | 165.88 | p-S6(S235/S236 | 385.36 | 1 | Colo858-signal2 | D11 | |
| JNK-IN-8 | WM-115 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 228.85 | p-Rb(S807/S811) | 67.48 | p-S6(S235/S236 | 192.17 | 1 | WM115-signal2 | D11 | |
| JNK-IN-8 | COLO 858 | 0.0000 | uM | 24 | hr | | Ki-67 | 2186.70 | p-Rb(S807/S811) | 147.06 | p-cJun(S73) | 28.84 | 1 | Colo858-signal3 | D11 | |
| JNK-IN-8 | WM1552C | 0.0000 | uM | 24 | hr | | Ki-67 | 1603.40 | p-Rb(S807/S811) | 107.85 | p-cJun(S73) | 142.51 | 1 | WM1552C-signal3 | D11 | |
| JNK-IN-8 | WM1552C | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 234.24 | p-Rb(S807/S811) | 115.31 | p-S6(S235/S236 | 377.79 | 1 | WM1552C-signal2 | D11 | |
| JNK-IN-8 | WM-115 | 0.0000 | uM | 24 | hr | | p27 Kip1 | 238.03 | p-Rb(S807/S811) | 74.48 | p-ERK(T202/Y204) | 630.06 | 1 | WM115-signal1 | D11 | |
| JNK-IN-8 | LOXIMVI | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 299.94 | p-Rb(S807/S811) | 232.62 | p-S6(S235/S236 | 413.74 | 1 | LOXIMVI-signal2 | D11 | |
| JNK-IN-8 | COLO 858 | 5.0000 | uM | 24 | hr | | Ki-67 | 2447.10 | p-Rb(S807/S811) | 231.66 | p-cJun(S73) | 37.00 | 1 | Colo858-signal3 | D2 | |
| JNK-IN-8 | COLO 858 | 5.0000 | uM | 24 | hr | | p27 Kip1 | 738.89 | p-Rb(S807/S811) | 249.29 | p-ERK(T202/Y204) | 766.04 | 1 | Colo858-signal1 | D2 | |
| JNK-IN-8 | WM-115 | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 248.53 | p-Rb(S807/S811) | 77.96 | p-S6(S235/S236 | 209.55 | 1 | WM115-signal2 | D2 | |
| JNK-IN-8 | WM-115 | 5.0000 | uM | 24 | hr | | Ki-67 | 867.38 | p-Rb(S807/S811) | 85.79 | p-cJun(S73) | 23.05 | 1 | WM115-signal3 | D2 | |
| JNK-IN-8 | WM-115 | 5.0000 | uM | 24 | hr | | p27 Kip1 | 230.19 | p-Rb(S807/S811) | 77.30 | p-ERK(T202/Y204) | 802.24 | 1 | WM115-signal1 | D2 | |
| JNK-IN-8 | LOXIMVI | 5.0000 | uM | 24 | hr | | p27 Kip1 | 464.53 | p-Rb(S807/S811) | 268.11 | p-ERK(T202/Y204) | 267.97 | 1 | LOXIMVI-signal1 | D2 | |
| JNK-IN-8 | WM1552C | 5.0000 | uM | 24 | hr | | p27 Kip1 | 304.56 | p-Rb(S807/S811) | 111.24 | p-ERK(T202/Y204) | 317.45 | 1 | WM1552C-signal1 | D2 | |
| JNK-IN-8 | LOXIMVI | 5.0000 | uM | 24 | hr | | Ki-67 | 3004.40 | p-Rb(S807/S811) | 244.06 | p-cJun(S73) | 51.77 | 1 | LOXIMVI-signal3 | D2 | |
| JNK-IN-8 | COLO 858 | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 315.08 | p-Rb(S807/S811) | 253.54 | p-S6(S235/S236 | 620.64 | 1 | Colo858-signal2 | D2 | |
| JNK-IN-8 | WM1552C | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 236.28 | p-Rb(S807/S811) | 113.21 | p-S6(S235/S236 | 450.52 | 1 | WM1552C-signal2 | D2 | |
| JNK-IN-8 | LOXIMVI | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 388.24 | p-Rb(S807/S811) | 277.19 | p-S6(S235/S236 | 582.84 | 1 | LOXIMVI-signal2 | D2 |