Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 197.88 | p-Rb(S807/S811) | 110.31 | p-S6(S235/S236 | 410.75 | 2 | WM1552C-signal2 | G8 |
| Vemurafenib | WM1552C | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 198.26 | p-Rb(S807/S811) | 101.11 | p-S6(S235/S236 | 404.63 | 1 | WM1552C-signal2 | B7 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 199.08 | p-Rb(S807/S811) | 67.78 | p-S6(S235/S236 | 151.66 | 1 | WM115-signal2 | F7 |
| Vemurafenib | WM1552C | JNK-IN-8 | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 199.56 | p-Rb(S807/S811) | 57.27 | p-S6(S235/S236 | 29.25 | 2 | WM1552C-signal2 | G2 |
| JNK-IN-8 | WM1552C | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 200.92 | p-Rb(S807/S811) | 113.95 | p-S6(S235/S236 | 415.95 | 2 | WM1552C-signal2 | E11 | |
| Vemurafenib | WM-115 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 201.09 | p-Rb(S807/S811) | 53.27 | p-S6(S235/S236 | 128.83 | 2 | WM115-signal2 | C6 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 201.42 | p-Rb(S807/S811) | 39.76 | p-S6(S235/S236 | 56.51 | 1 | WM115-signal2 | F4 |
| JNK-IN-8 | WM1552C | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 202.01 | p-Rb(S807/S811) | 113.23 | p-S6(S235/S236 | 403.64 | 2 | WM1552C-signal2 | E7 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 202.11 | p-Rb(S807/S811) | 70.44 | p-S6(S235/S236 | 160.70 | 2 | WM115-signal2 | G8 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 203.04 | p-Rb(S807/S811) | 68.91 | p-S6(S235/S236 | 195.37 | 1 | WM115-signal2 | F11 |
| Vemurafenib | LOXIMVI | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 203.52 | p-Rb(S807/S811) | 97.55 | p-S6(S235/S236 | 181.29 | 1 | LOXIMVI-signal2 | B3 | |
| JNK-IN-8 | WM1552C | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 204.00 | p-Rb(S807/S811) | 111.59 | p-S6(S235/S236 | 385.25 | 2 | WM1552C-signal2 | E4 | |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 204.23 | p-Rb(S807/S811) | 70.93 | p-S6(S235/S236 | 342.80 | 1 | WM1552C-signal2 | F5 |
| Vemurafenib | COLO 858 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 204.59 | p-Rb(S807/S811) | 83.78 | p-S6(S235/S236 | 220.01 | 1 | Colo858-signal2 | B6 | |
| JNK-IN-8 | WM-115 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 205.29 | p-Rb(S807/S811) | 76.65 | p-S6(S235/S236 | 177.08 | 1 | WM115-signal2 | D5 | |
| JNK-IN-8 | WM1552C | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 205.45 | p-Rb(S807/S811) | 114.75 | p-S6(S235/S236 | 404.26 | 2 | WM1552C-signal2 | E8 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 205.62 | p-Rb(S807/S811) | 70.03 | p-S6(S235/S236 | 181.80 | 1 | WM115-signal2 | F10 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 206.61 | p-Rb(S807/S811) | 41.17 | p-S6(S235/S236 | 77.73 | 1 | WM115-signal2 | F5 |
| Vemurafenib | WM1552C | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 208.13 | p-Rb(S807/S811) | 96.36 | p-S6(S235/S236 | 376.62 | 1 | WM1552C-signal2 | B6 | |
| Vemurafenib | WM-115 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 208.23 | p-Rb(S807/S811) | 67.34 | p-S6(S235/S236 | 176.14 | 1 | WM115-signal2 | B7 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 208.71 | p-Rb(S807/S811) | 69.04 | p-S6(S235/S236 | 185.81 | 2 | WM115-signal2 | G10 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 208.77 | p-Rb(S807/S811) | 116.05 | p-S6(S235/S236 | 419.33 | 1 | WM1552C-signal2 | F11 |
| Vemurafenib | WM-115 | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 209.18 | p-Rb(S807/S811) | 48.45 | p-S6(S235/S236 | 30.86 | 2 | WM115-signal2 | C2 | |
| Vemurafenib | WM-115 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 209.33 | p-Rb(S807/S811) | 53.83 | p-S6(S235/S236 | 130.34 | 1 | WM115-signal2 | B6 | |
| Vemurafenib | WM-115 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 209.37 | p-Rb(S807/S811) | 65.40 | p-S6(S235/S236 | 188.91 | 2 | WM115-signal2 | C10 |