Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | WM1552C | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 177.12 | p-Rb(S807/S811) | 56.01 | p-S6(S235/S236 | 356.27 | 2 | WM1552C-signal2 | C4 | |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 177.34 | p-Rb(S807/S811) | 61.94 | p-S6(S235/S236 | 398.32 | 2 | WM1552C-signal2 | G4 |
| Vemurafenib | WM-115 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 179.29 | p-Rb(S807/S811) | 38.89 | p-S6(S235/S236 | 65.75 | 2 | WM115-signal2 | C4 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 179.49 | p-Rb(S807/S811) | 67.38 | p-S6(S235/S236 | 142.55 | 2 | WM115-signal2 | G7 |
| JNK-IN-8 | WM1552C | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 179.59 | p-Rb(S807/S811) | 113.28 | p-S6(S235/S236 | 408.38 | 2 | WM1552C-signal2 | E9 | |
| Vemurafenib | WM-115 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 180.39 | p-Rb(S807/S811) | 38.47 | p-S6(S235/S236 | 77.58 | 1 | WM115-signal2 | B5 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 181.02 | p-Rb(S807/S811) | 67.72 | p-S6(S235/S236 | 155.98 | 2 | WM115-signal2 | G9 |
| Vemurafenib | WM1552C | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 181.99 | p-Rb(S807/S811) | 102.95 | p-S6(S235/S236 | 423.14 | 1 | WM1552C-signal2 | B8 | |
| Vemurafenib | WM1552C | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 182.24 | p-Rb(S807/S811) | 111.29 | p-S6(S235/S236 | 389.65 | 2 | WM1552C-signal2 | C10 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 182.30 | p-Rb(S807/S811) | 53.72 | p-S6(S235/S236 | 104.93 | 1 | WM115-signal2 | F6 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 182.61 | p-Rb(S807/S811) | 38.78 | p-S6(S235/S236 | 51.74 | 2 | WM115-signal2 | G4 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 183.28 | p-Rb(S807/S811) | 55.71 | p-S6(S235/S236 | 111.37 | 2 | WM115-signal2 | G6 |
| JNK-IN-8 | WM1552C | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 184.24 | p-Rb(S807/S811) | 113.51 | p-S6(S235/S236 | 409.57 | 1 | WM1552C-signal2 | D9 | |
| Vemurafenib | WM1552C | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 184.35 | p-Rb(S807/S811) | 50.13 | p-S6(S235/S236 | 228.77 | 2 | WM1552C-signal2 | C2 | |
| Vemurafenib | LOXIMVI | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 184.72 | p-Rb(S807/S811) | 84.06 | p-S6(S235/S236 | 180.02 | 2 | LOXIMVI-signal2 | C3 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 189.27 | p-Rb(S807/S811) | 66.71 | p-S6(S235/S236 | 192.92 | 2 | WM115-signal2 | G11 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 190.31 | p-Rb(S807/S811) | 96.89 | p-S6(S235/S236 | 375.87 | 1 | WM1552C-signal2 | F7 |
| Vemurafenib | WM-115 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 190.48 | p-Rb(S807/S811) | 38.37 | p-S6(S235/S236 | 66.01 | 1 | WM115-signal2 | B4 | |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 191.70 | p-Rb(S807/S811) | 97.70 | p-S6(S235/S236 | 403.09 | 2 | WM1552C-signal2 | G7 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 191.90 | p-Rb(S807/S811) | 81.85 | p-S6(S235/S236 | 199.11 | 1 | Colo858-signal2 | F6 |
| JNK-IN-8 | WM1552C | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 192.93 | p-Rb(S807/S811) | 112.08 | p-S6(S235/S236 | 409.76 | 2 | WM1552C-signal2 | E10 | |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 194.38 | p-Rb(S807/S811) | 84.75 | p-S6(S235/S236 | 196.38 | 2 | Colo858-signal2 | G6 |
| Vemurafenib | WM-115 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 196.19 | p-Rb(S807/S811) | 67.83 | p-S6(S235/S236 | 199.48 | 1 | WM115-signal2 | B8 | |
| JNK-IN-8 | WM-115 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 197.00 | p-Rb(S807/S811) | 65.37 | p-S6(S235/S236 | 186.60 | 1 | WM115-signal2 | D10 | |
| Vemurafenib | WM-115 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 197.62 | p-Rb(S807/S811) | 67.65 | p-S6(S235/S236 | 195.82 | 2 | WM115-signal2 | C11 |