Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| JNK-IN-8 | WM1552C | 0.0033 | uM | 24 | hr | | Ki-67 | 1634.60 | p-Rb(S807/S811) | 105.63 | p-cJun(S73) | 145.10 | 2 | WM1552C-signal3 | E10 | |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0082 | uM | 24 | hr | | Ki-67 | 2742.00 | p-Rb(S807/S811) | 188.71 | p-cJun(S73) | 92.00 | 1 | LOXIMVI-signal3 | F9 |
| JNK-IN-8 | WM1552C | 2.0000 | uM | 24 | hr | | Ki-67 | 1645.70 | p-Rb(S807/S811) | 114.19 | p-cJun(S73) | 27.88 | 2 | WM1552C-signal3 | E3 | |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0205 | uM | 24 | hr | | Ki-67 | 2734.80 | p-Rb(S807/S811) | 188.75 | p-cJun(S73) | 65.47 | 1 | LOXIMVI-signal3 | F8 |
| JNK-IN-8 | WM1552C | 0.3200 | uM | 24 | hr | | Ki-67 | 1603.10 | p-Rb(S807/S811) | 108.59 | p-cJun(S73) | 104.20 | 2 | WM1552C-signal3 | E5 | |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0000 | uM | 24 | hr | | Ki-67 | 2934.10 | p-Rb(S807/S811) | 203.26 | p-cJun(S73) | 120.51 | 2 | LOXIMVI-signal3 | G11 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.8000 | uM | 24 | hr | | Ki-67 | 2219.70 | p-Rb(S807/S811) | 100.07 | p-cJun(S73) | 23.48 | 2 | LOXIMVI-signal3 | G4 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0033 | uM | 24 | hr | | Ki-67 | 1563.00 | p-Rb(S807/S811) | 101.88 | p-cJun(S73) | 150.84 | 1 | WM1552C-signal3 | F10 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0000 | uM | 24 | hr | | Ki-67 | 1640.70 | p-Rb(S807/S811) | 107.50 | p-cJun(S73) | 145.58 | 1 | WM1552C-signal3 | F11 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 2.0000 | uM | 24 | hr | | Ki-67 | 2231.10 | p-Rb(S807/S811) | 90.56 | p-cJun(S73) | 23.75 | 2 | LOXIMVI-signal3 | G3 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.8000 | uM | 24 | hr | | Ki-67 | 1070.90 | p-Rb(S807/S811) | 51.39 | p-cJun(S73) | 29.77 | 1 | WM1552C-signal3 | F4 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 5.0000 | uM | 24 | hr | | Ki-67 | 2767.00 | p-Rb(S807/S811) | 114.93 | p-cJun(S73) | 35.58 | 2 | LOXIMVI-signal3 | G2 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.1280 | uM | 24 | hr | | Ki-67 | 1358.60 | p-Rb(S807/S811) | 88.45 | p-cJun(S73) | 136.95 | 1 | WM1552C-signal3 | F6 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0512 | uM | 24 | hr | | Ki-67 | 2517.90 | p-Rb(S807/S811) | 172.29 | p-cJun(S73) | 48.52 | 2 | LOXIMVI-signal3 | G7 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0000 | uM | 24 | hr | | Ki-67 | 1730.30 | p-Rb(S807/S811) | 108.00 | p-cJun(S73) | 145.49 | 2 | WM1552C-signal3 | G11 |
| Vemurafenib | COLO 858 | 0.1280 | uM | 24 | hr | | p27 Kip1 | 849.44 | p-Rb(S807/S811) | 79.57 | p-ERK(T202/Y204) | 75.64 | 1 | Colo858-signal1 | B6 | |
| Vemurafenib | WM-115 | 2.0000 | uM | 24 | hr | | p27 Kip1 | 325.41 | p-Rb(S807/S811) | 43.62 | p-ERK(T202/Y204) | 15.11 | 1 | WM115-signal1 | B3 | |
| JNK-IN-8 | COLO 858 | 0.0033 | uM | 24 | hr | | p27 Kip1 | 442.59 | p-Rb(S807/S811) | 160.97 | p-ERK(T202/Y204) | 615.32 | 2 | Colo858-signal1 | E10 | |
| Vemurafenib | COLO 858 | 5.0000 | uM | 24 | hr | | p27 Kip1 | 1101.80 | p-Rb(S807/S811) | 48.19 | p-ERK(T202/Y204) | 9.79 | 1 | Colo858-signal1 | B2 | |
| Vemurafenib | WM-115 | 0.8000 | uM | 24 | hr | | p27 Kip1 | 304.70 | p-Rb(S807/S811) | 38.57 | p-ERK(T202/Y204) | 23.27 | 1 | WM115-signal1 | B4 | |
| Vemurafenib | WM-115 | 0.3200 | uM | 24 | hr | | p27 Kip1 | 263.18 | p-Rb(S807/S811) | 37.97 | p-ERK(T202/Y204) | 43.14 | 1 | WM115-signal1 | B5 | |
| Vemurafenib | WM-115 | 0.0033 | uM | 24 | hr | | p27 Kip1 | 228.00 | p-Rb(S807/S811) | 72.02 | p-ERK(T202/Y204) | 575.75 | 1 | WM115-signal1 | B10 | |
| JNK-IN-8 | COLO 858 | 0.0082 | uM | 24 | hr | | p27 Kip1 | 436.36 | p-Rb(S807/S811) | 155.67 | p-ERK(T202/Y204) | 648.15 | 1 | Colo858-signal1 | D9 | |
| Vemurafenib | WM-115 | 0.0000 | uM | 24 | hr | | p27 Kip1 | 242.95 | p-Rb(S807/S811) | 73.13 | p-ERK(T202/Y204) | 635.44 | 1 | WM115-signal1 | B11 | |
| Vemurafenib | COLO 858 | 0.0033 | uM | 24 | hr | | p27 Kip1 | 452.40 | p-Rb(S807/S811) | 159.51 | p-ERK(T202/Y204) | 579.26 | 1 | Colo858-signal1 | B10 |