Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 230.14 | p-Rb(S807/S811) | 187.63 | p-S6(S235/S236 | 409.48 | 2 | LOXIMVI-signal2 | G7 |
| Vemurafenib | LOXIMVI | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 203.52 | p-Rb(S807/S811) | 97.55 | p-S6(S235/S236 | 181.29 | 1 | LOXIMVI-signal2 | B3 | |
| JNK-IN-8 | LOXIMVI | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 377.73 | p-Rb(S807/S811) | 274.50 | p-S6(S235/S236 | 619.52 | 2 | LOXIMVI-signal2 | E3 | |
| Vemurafenib | LOXIMVI | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 184.72 | p-Rb(S807/S811) | 84.06 | p-S6(S235/S236 | 180.02 | 2 | LOXIMVI-signal2 | C3 | |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 268.49 | p-Rb(S807/S811) | 170.62 | p-S6(S235/S236 | 412.34 | 2 | LOXIMVI-signal2 | G6 |
| Vemurafenib | LOXIMVI | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 298.38 | p-Rb(S807/S811) | 219.79 | p-S6(S235/S236 | 438.42 | 1 | LOXIMVI-signal2 | B8 | |
| Vemurafenib | LOXIMVI | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 249.36 | p-Rb(S807/S811) | 148.83 | p-S6(S235/S236 | 383.67 | 2 | LOXIMVI-signal2 | C5 | |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 229.67 | p-Rb(S807/S811) | 98.04 | p-S6(S235/S236 | 97.15 | 1 | LOXIMVI-signal2 | F3 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 233.71 | p-Rb(S807/S811) | 136.67 | p-S6(S235/S236 | 375.36 | 2 | LOXIMVI-signal2 | G5 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 351.16 | p-Rb(S807/S811) | 100.40 | p-S6(S235/S236 | 22.18 | 2 | LOXIMVI-signal2 | G2 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 300.97 | p-Rb(S807/S811) | 216.71 | p-S6(S235/S236 | 433.18 | 2 | LOXIMVI-signal2 | G10 |
| Vemurafenib | LOXIMVI | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 237.39 | p-Rb(S807/S811) | 127.65 | p-S6(S235/S236 | 339.13 | 1 | LOXIMVI-signal2 | B4 | |
| JNK-IN-8 | LOXIMVI | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 267.83 | p-Rb(S807/S811) | 225.75 | p-S6(S235/S236 | 426.66 | 1 | LOXIMVI-signal2 | D9 | |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 238.51 | p-Rb(S807/S811) | 220.71 | p-S6(S235/S236 | 444.78 | 1 | LOXIMVI-signal2 | F9 |
| JNK-IN-8 | LOXIMVI | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 242.93 | p-Rb(S807/S811) | 227.00 | p-S6(S235/S236 | 449.29 | 2 | LOXIMVI-signal2 | E10 | |
| JNK-IN-8 | LOXIMVI | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 388.24 | p-Rb(S807/S811) | 277.19 | p-S6(S235/S236 | 582.84 | 1 | LOXIMVI-signal2 | D2 | |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 267.75 | p-Rb(S807/S811) | 208.98 | p-S6(S235/S236 | 429.59 | 1 | LOXIMVI-signal2 | F8 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 233.98 | p-Rb(S807/S811) | 191.85 | p-S6(S235/S236 | 428.50 | 1 | LOXIMVI-signal2 | F7 |
| Vemurafenib | LOXIMVI | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 264.06 | p-Rb(S807/S811) | 220.85 | p-S6(S235/S236 | 434.18 | 2 | LOXIMVI-signal2 | C9 | |
| Vemurafenib | LOXIMVI | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 248.94 | p-Rb(S807/S811) | 222.89 | p-S6(S235/S236 | 425.05 | 2 | LOXIMVI-signal2 | C10 | |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 229.22 | p-Rb(S807/S811) | 100.85 | p-S6(S235/S236 | 225.60 | 1 | LOXIMVI-signal2 | F4 |
| JNK-IN-8 | LOXIMVI | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 283.60 | p-Rb(S807/S811) | 227.06 | p-S6(S235/S236 | 453.19 | 2 | LOXIMVI-signal2 | E7 | |
| JNK-IN-8 | LOXIMVI | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 290.00 | p-Rb(S807/S811) | 244.26 | p-S6(S235/S236 | 469.02 | 1 | LOXIMVI-signal2 | D6 | |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 358.85 | p-Rb(S807/S811) | 104.29 | p-S6(S235/S236 | 19.60 | 1 | LOXIMVI-signal2 | F2 |
| JNK-IN-8 | LOXIMVI | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 312.66 | p-Rb(S807/S811) | 236.29 | p-S6(S235/S236 | 442.43 | 2 | LOXIMVI-signal2 | E11 |