Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| JNK-IN-8 | WM-115 | 0.0082 | uM | 24 | hr | | Ki-67 | 787.98 | p-Rb(S807/S811) | 73.62 | p-cJun(S73) | 42.75 | 2 | WM115-signal3 | E9 | |
| JNK-IN-8 | WM-115 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 225.21 | p-Rb(S807/S811) | 68.46 | p-S6(S235/S236 | 185.57 | 2 | WM115-signal2 | E9 | |
| JNK-IN-8 | WM-115 | 0.0205 | uM | 24 | hr | | p27 Kip1 | 228.02 | p-Rb(S807/S811) | 77.98 | p-ERK(T202/Y204) | 657.81 | 2 | WM115-signal1 | E8 | |
| JNK-IN-8 | LOXIMVI | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 281.63 | p-Rb(S807/S811) | 231.63 | p-S6(S235/S236 | 455.97 | 2 | LOXIMVI-signal2 | E8 | |
| JNK-IN-8 | LOXIMVI | 0.0205 | uM | 24 | hr | | p27 Kip1 | 286.32 | p-Rb(S807/S811) | 204.47 | p-ERK(T202/Y204) | 198.65 | 2 | LOXIMVI-signal1 | E8 | |
| JNK-IN-8 | COLO 858 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 311.93 | p-Rb(S807/S811) | 166.54 | p-S6(S235/S236 | 387.41 | 2 | Colo858-signal2 | E8 | |
| JNK-IN-8 | WM1552C | 0.0205 | uM | 24 | hr | | p27 Kip1 | 245.39 | p-Rb(S807/S811) | 107.49 | p-ERK(T202/Y204) | 270.03 | 2 | WM1552C-signal1 | E8 | |
| JNK-IN-8 | COLO 858 | 0.0205 | uM | 24 | hr | | Ki-67 | 2269.90 | p-Rb(S807/S811) | 156.97 | p-cJun(S73) | 29.44 | 2 | Colo858-signal3 | E8 | |
| JNK-IN-8 | COLO 858 | 0.0205 | uM | 24 | hr | | p27 Kip1 | 437.19 | p-Rb(S807/S811) | 168.12 | p-ERK(T202/Y204) | 644.13 | 2 | Colo858-signal1 | E8 | |
| JNK-IN-8 | LOXIMVI | 0.0205 | uM | 24 | hr | | Ki-67 | 2981.20 | p-Rb(S807/S811) | 212.09 | p-cJun(S73) | 82.93 | 2 | LOXIMVI-signal3 | E8 | |
| JNK-IN-8 | WM1552C | 0.0205 | uM | 24 | hr | | Ki-67 | 1660.00 | p-Rb(S807/S811) | 109.84 | p-cJun(S73) | 146.02 | 2 | WM1552C-signal3 | E8 | |
| JNK-IN-8 | WM-115 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 223.09 | p-Rb(S807/S811) | 70.57 | p-S6(S235/S236 | 184.86 | 2 | WM115-signal2 | E8 | |
| JNK-IN-8 | WM1552C | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 205.45 | p-Rb(S807/S811) | 114.75 | p-S6(S235/S236 | 404.26 | 2 | WM1552C-signal2 | E8 | |
| JNK-IN-8 | WM-115 | 0.0205 | uM | 24 | hr | | Ki-67 | 798.51 | p-Rb(S807/S811) | 76.68 | p-cJun(S73) | 41.54 | 2 | WM115-signal3 | E8 | |
| JNK-IN-8 | LOXIMVI | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 283.60 | p-Rb(S807/S811) | 227.06 | p-S6(S235/S236 | 453.19 | 2 | LOXIMVI-signal2 | E7 | |
| JNK-IN-8 | LOXIMVI | 0.0512 | uM | 24 | hr | | p27 Kip1 | 303.12 | p-Rb(S807/S811) | 207.96 | p-ERK(T202/Y204) | 204.10 | 2 | LOXIMVI-signal1 | E7 | |
| JNK-IN-8 | WM-115 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 236.12 | p-Rb(S807/S811) | 76.30 | p-S6(S235/S236 | 187.61 | 2 | WM115-signal2 | E7 | |
| JNK-IN-8 | COLO 858 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 333.07 | p-Rb(S807/S811) | 173.37 | p-S6(S235/S236 | 412.91 | 2 | Colo858-signal2 | E7 | |
| JNK-IN-8 | LOXIMVI | 0.0512 | uM | 24 | hr | | Ki-67 | 2817.60 | p-Rb(S807/S811) | 205.31 | p-cJun(S73) | 68.42 | 2 | LOXIMVI-signal3 | E7 | |
| JNK-IN-8 | COLO 858 | 0.0512 | uM | 24 | hr | | Ki-67 | 2172.00 | p-Rb(S807/S811) | 160.38 | p-cJun(S73) | 29.06 | 2 | Colo858-signal3 | E7 | |
| JNK-IN-8 | COLO 858 | 0.0512 | uM | 24 | hr | | p27 Kip1 | 429.12 | p-Rb(S807/S811) | 167.32 | p-ERK(T202/Y204) | 661.59 | 2 | Colo858-signal1 | E7 | |
| JNK-IN-8 | WM1552C | 0.0512 | uM | 24 | hr | | Ki-67 | 1577.80 | p-Rb(S807/S811) | 104.89 | p-cJun(S73) | 132.44 | 2 | WM1552C-signal3 | E7 | |
| JNK-IN-8 | WM-115 | 0.0512 | uM | 24 | hr | | Ki-67 | 765.62 | p-Rb(S807/S811) | 80.82 | p-cJun(S73) | 36.31 | 2 | WM115-signal3 | E7 | |
| JNK-IN-8 | WM1552C | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 202.01 | p-Rb(S807/S811) | 113.23 | p-S6(S235/S236 | 403.64 | 2 | WM1552C-signal2 | E7 | |
| JNK-IN-8 | WM1552C | 0.0512 | uM | 24 | hr | | p27 Kip1 | 242.80 | p-Rb(S807/S811) | 108.49 | p-ERK(T202/Y204) | 267.00 | 2 | WM1552C-signal1 | E7 |