Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0000 | uM | 24 | hr | | Ki-67 | 782.51 | p-Rb(S807/S811) | 75.83 | p-cJun(S73) | 51.58 | 1 | WM115-signal3 | F11 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.0000 | uM | 24 | hr | | Ki-67 | 2257.00 | p-Rb(S807/S811) | 151.09 | p-cJun(S73) | 29.94 | 1 | Colo858-signal3 | F11 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0000 | uM | 24 | hr | | Ki-67 | 3032.30 | p-Rb(S807/S811) | 209.50 | p-cJun(S73) | 127.94 | 1 | LOXIMVI-signal3 | F11 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0033 | uM | 24 | hr | | Ki-67 | 1563.00 | p-Rb(S807/S811) | 101.88 | p-cJun(S73) | 150.84 | 1 | WM1552C-signal3 | F10 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p27 Kip1 | 307.03 | p-Rb(S807/S811) | 198.87 | p-ERK(T202/Y204) | 175.67 | 1 | LOXIMVI-signal1 | F10 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 205.62 | p-Rb(S807/S811) | 70.03 | p-S6(S235/S236 | 181.80 | 1 | WM115-signal2 | F10 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 288.89 | p-Rb(S807/S811) | 152.75 | p-S6(S235/S236 | 379.48 | 1 | Colo858-signal2 | F10 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 211.27 | p-Rb(S807/S811) | 111.74 | p-S6(S235/S236 | 403.48 | 1 | WM1552C-signal2 | F10 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p27 Kip1 | 231.78 | p-Rb(S807/S811) | 102.69 | p-ERK(T202/Y204) | 234.80 | 1 | WM1552C-signal1 | F10 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0033 | uM | 24 | hr | | Ki-67 | 801.31 | p-Rb(S807/S811) | 74.66 | p-cJun(S73) | 48.32 | 1 | WM115-signal3 | F10 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p27 Kip1 | 224.00 | p-Rb(S807/S811) | 72.74 | p-ERK(T202/Y204) | 584.05 | 1 | WM115-signal1 | F10 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p27 Kip1 | 459.60 | p-Rb(S807/S811) | 160.13 | p-ERK(T202/Y204) | 573.25 | 1 | Colo858-signal1 | F10 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.0033 | uM | 24 | hr | | Ki-67 | 2257.40 | p-Rb(S807/S811) | 152.83 | p-cJun(S73) | 28.15 | 1 | Colo858-signal3 | F10 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0033 | uM | 24 | hr | | Ki-67 | 2882.90 | p-Rb(S807/S811) | 203.40 | p-cJun(S73) | 97.65 | 1 | LOXIMVI-signal3 | F10 |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 269.36 | p-Rb(S807/S811) | 224.35 | p-S6(S235/S236 | 447.46 | 1 | LOXIMVI-signal2 | F10 |
| JNK-IN-8 | WM1552C | 0.0082 | uM | 24 | hr | | Ki-67 | 1586.10 | p-Rb(S807/S811) | 106.76 | p-cJun(S73) | 145.37 | 2 | WM1552C-signal3 | E9 | |
| JNK-IN-8 | LOXIMVI | 0.0082 | uM | 24 | hr | | p27 Kip1 | 300.54 | p-Rb(S807/S811) | 201.98 | p-ERK(T202/Y204) | 205.87 | 2 | LOXIMVI-signal1 | E9 | |
| JNK-IN-8 | WM1552C | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 179.59 | p-Rb(S807/S811) | 113.28 | p-S6(S235/S236 | 408.38 | 2 | WM1552C-signal2 | E9 | |
| JNK-IN-8 | COLO 858 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 373.77 | p-Rb(S807/S811) | 163.58 | p-S6(S235/S236 | 386.62 | 2 | Colo858-signal2 | E9 | |
| JNK-IN-8 | LOXIMVI | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 254.16 | p-Rb(S807/S811) | 231.99 | p-S6(S235/S236 | 458.18 | 2 | LOXIMVI-signal2 | E9 | |
| JNK-IN-8 | WM-115 | 0.0082 | uM | 24 | hr | | Ki-67 | 787.98 | p-Rb(S807/S811) | 73.62 | p-cJun(S73) | 42.75 | 2 | WM115-signal3 | E9 | |
| JNK-IN-8 | COLO 858 | 0.0082 | uM | 24 | hr | | Ki-67 | 2294.40 | p-Rb(S807/S811) | 151.40 | p-cJun(S73) | 29.18 | 2 | Colo858-signal3 | E9 | |
| JNK-IN-8 | COLO 858 | 0.0082 | uM | 24 | hr | | p27 Kip1 | 438.93 | p-Rb(S807/S811) | 156.13 | p-ERK(T202/Y204) | 620.57 | 2 | Colo858-signal1 | E9 | |
| JNK-IN-8 | WM-115 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 225.21 | p-Rb(S807/S811) | 68.46 | p-S6(S235/S236 | 185.57 | 2 | WM115-signal2 | E9 | |
| JNK-IN-8 | WM-115 | 0.0082 | uM | 24 | hr | | p27 Kip1 | 226.04 | p-Rb(S807/S811) | 77.90 | p-ERK(T202/Y204) | 670.95 | 2 | WM115-signal1 | E9 |