Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 208.77 | p-Rb(S807/S811) | 116.05 | p-S6(S235/S236 | 419.33 | 1 | WM1552C-signal2 | F11 |
| JNK-IN-8 | WM1552C | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 233.60 | p-Rb(S807/S811) | 115.43 | p-S6(S235/S236 | 404.08 | 2 | WM1552C-signal2 | E6 | |
| JNK-IN-8 | WM1552C | 5.0000 | uM | 24 | hr | | Ki-67 | 1547.50 | p-Rb(S807/S811) | 115.39 | p-cJun(S73) | 22.53 | 1 | WM1552C-signal3 | D2 | |
| JNK-IN-8 | WM1552C | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 244.72 | p-Rb(S807/S811) | 115.35 | p-S6(S235/S236 | 425.96 | 1 | WM1552C-signal2 | D8 | |
| JNK-IN-8 | WM1552C | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 234.24 | p-Rb(S807/S811) | 115.31 | p-S6(S235/S236 | 377.79 | 1 | WM1552C-signal2 | D11 | |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.3200 | uM | 24 | hr | | Ki-67 | 2301.20 | p-Rb(S807/S811) | 115.21 | p-cJun(S73) | 27.54 | 2 | LOXIMVI-signal3 | G5 |
| JNK-IN-8 | WM1552C | 0.8000 | uM | 24 | hr | | p27 Kip1 | 247.69 | p-Rb(S807/S811) | 115.02 | p-ERK(T202/Y204) | 276.76 | 1 | WM1552C-signal1 | D4 | |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 5.0000 | uM | 24 | hr | | Ki-67 | 2767.00 | p-Rb(S807/S811) | 114.93 | p-cJun(S73) | 35.58 | 2 | LOXIMVI-signal3 | G2 |
| JNK-IN-8 | WM1552C | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 205.45 | p-Rb(S807/S811) | 114.75 | p-S6(S235/S236 | 404.26 | 2 | WM1552C-signal2 | E8 | |
| JNK-IN-8 | WM1552C | 0.8000 | uM | 24 | hr | | Ki-67 | 1751.50 | p-Rb(S807/S811) | 114.25 | p-cJun(S73) | 56.72 | 2 | WM1552C-signal3 | E4 | |
| JNK-IN-8 | WM1552C | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 221.29 | p-Rb(S807/S811) | 114.21 | p-S6(S235/S236 | 384.84 | 1 | WM1552C-signal2 | D6 | |
| JNK-IN-8 | WM1552C | 0.8000 | uM | 24 | hr | | Ki-67 | 1714.80 | p-Rb(S807/S811) | 114.20 | p-cJun(S73) | 63.58 | 1 | WM1552C-signal3 | D4 | |
| JNK-IN-8 | WM1552C | 2.0000 | uM | 24 | hr | | Ki-67 | 1645.70 | p-Rb(S807/S811) | 114.19 | p-cJun(S73) | 27.88 | 2 | WM1552C-signal3 | E3 | |
| JNK-IN-8 | WM1552C | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 249.08 | p-Rb(S807/S811) | 114.01 | p-S6(S235/S236 | 401.71 | 1 | WM1552C-signal2 | D5 | |
| JNK-IN-8 | WM1552C | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 200.92 | p-Rb(S807/S811) | 113.95 | p-S6(S235/S236 | 415.95 | 2 | WM1552C-signal2 | E11 | |
| JNK-IN-8 | WM1552C | 2.0000 | uM | 24 | hr | | p27 Kip1 | 258.20 | p-Rb(S807/S811) | 113.91 | p-ERK(T202/Y204) | 277.27 | 1 | WM1552C-signal1 | D3 | |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 277.62 | p-Rb(S807/S811) | 113.74 | p-S6(S235/S236 | 415.75 | 2 | WM1552C-signal2 | G11 |
| JNK-IN-8 | WM1552C | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 184.24 | p-Rb(S807/S811) | 113.51 | p-S6(S235/S236 | 409.57 | 1 | WM1552C-signal2 | D9 | |
| JNK-IN-8 | WM1552C | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 262.28 | p-Rb(S807/S811) | 113.37 | p-S6(S235/S236 | 413.92 | 1 | WM1552C-signal2 | D4 | |
| JNK-IN-8 | WM1552C | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 179.59 | p-Rb(S807/S811) | 113.28 | p-S6(S235/S236 | 408.38 | 2 | WM1552C-signal2 | E9 | |
| JNK-IN-8 | WM1552C | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 202.01 | p-Rb(S807/S811) | 113.23 | p-S6(S235/S236 | 403.64 | 2 | WM1552C-signal2 | E7 | |
| JNK-IN-8 | WM1552C | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 236.28 | p-Rb(S807/S811) | 113.21 | p-S6(S235/S236 | 450.52 | 1 | WM1552C-signal2 | D2 | |
| Vemurafenib | LOXIMVI | JNK-IN-8 | 0.3200 | uM | 24 | hr | | Ki-67 | 2320.10 | p-Rb(S807/S811) | 113.12 | p-cJun(S73) | 29.40 | 1 | LOXIMVI-signal3 | F5 |
| JNK-IN-8 | WM1552C | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 238.67 | p-Rb(S807/S811) | 112.35 | p-S6(S235/S236 | 403.49 | 2 | WM1552C-signal2 | E5 | |
| JNK-IN-8 | WM1552C | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 285.27 | p-Rb(S807/S811) | 112.32 | p-S6(S235/S236 | 447.61 | 2 | WM1552C-signal2 | E2 |