Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | COLO 858 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 165.33 | p-Rb(S807/S811) | 58.60 | p-S6(S235/S236 | 48.12 | 1 | Colo858-signal2 | B4 | |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 164.14 | p-Rb(S807/S811) | 55.90 | p-S6(S235/S236 | 45.82 | 2 | Colo858-signal2 | G4 |
| Vemurafenib | COLO 858 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 163.91 | p-Rb(S807/S811) | 54.08 | p-S6(S235/S236 | 23.01 | 1 | Colo858-signal2 | B3 | |
| Vemurafenib | WM1552C | JNK-IN-8 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 161.46 | p-Rb(S807/S811) | 50.96 | p-S6(S235/S236 | 229.99 | 1 | WM1552C-signal2 | F3 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 158.64 | p-Rb(S807/S811) | 76.31 | p-S6(S235/S236 | 405.08 | 2 | WM1552C-signal2 | G5 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 158.30 | p-Rb(S807/S811) | 60.54 | p-S6(S235/S236 | 363.25 | 1 | WM1552C-signal2 | F4 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 155.41 | p-Rb(S807/S811) | 59.98 | p-S6(S235/S236 | 99.31 | 1 | Colo858-signal2 | F5 |
| Vemurafenib | WM1552C | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 153.80 | p-Rb(S807/S811) | 53.66 | p-S6(S235/S236 | 392.09 | 1 | WM1552C-signal2 | B4 | |
| Vemurafenib | COLO 858 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 152.45 | p-Rb(S807/S811) | 55.46 | p-S6(S235/S236 | 57.68 | 2 | Colo858-signal2 | C4 | |
| Vemurafenib | COLO 858 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 150.91 | p-Rb(S807/S811) | 54.62 | p-S6(S235/S236 | 93.11 | 2 | Colo858-signal2 | C5 | |
| Vemurafenib | COLO 858 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 150.06 | p-Rb(S807/S811) | 51.74 | p-S6(S235/S236 | 21.56 | 2 | Colo858-signal2 | C3 | |
| Vemurafenib | WM-115 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 148.64 | p-Rb(S807/S811) | 35.95 | p-S6(S235/S236 | 64.00 | 2 | WM115-signal2 | C5 | |
| Vemurafenib | WM1552C | JNK-IN-8 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 146.05 | p-Rb(S807/S811) | 52.87 | p-S6(S235/S236 | 247.44 | 2 | WM1552C-signal2 | G3 |
| Vemurafenib | COLO 858 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 144.45 | p-Rb(S807/S811) | 54.34 | p-S6(S235/S236 | 77.03 | 1 | Colo858-signal2 | B5 | |
| Vemurafenib | WM1552C | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 144.13 | p-Rb(S807/S811) | 66.51 | p-S6(S235/S236 | 373.65 | 1 | WM1552C-signal2 | B5 | |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 125.76 | p-Rb(S807/S811) | 58.82 | p-S6(S235/S236 | 110.32 | 2 | Colo858-signal2 | G5 |
| Vemurafenib | WM1552C | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 123.39 | p-Rb(S807/S811) | 42.15 | p-S6(S235/S236 | 347.41 | 1 | WM1552C-signal2 | B3 | |
| Vemurafenib | WM1552C | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 120.64 | p-Rb(S807/S811) | 41.60 | p-S6(S235/S236 | 325.46 | 2 | WM1552C-signal2 | C3 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | p-Rb(S807/S811) | p-S6(S235/S236 | 1 | WM115-signal2 | F8 | |||
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | p-Rb(S807/S811) | p-S6(S235/S236 | 1 | WM115-signal2 | F9 |