Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | WM-115 | JNK-IN-8 | 5.0000 | uM | 24 | hr | | Ki-67 | 614.46 | p-Rb(S807/S811) | 62.48 | p-cJun(S73) | 20.25 | 1 | WM115-signal3 | F2 |
| Vemurafenib | WM-115 | 0.0512 | uM | 24 | hr | | Ki-67 | 678.09 | p-Rb(S807/S811) | 65.24 | p-cJun(S73) | 51.35 | 2 | WM115-signal3 | C7 | |
| Vemurafenib | WM-115 | 0.8000 | uM | 24 | hr | | Ki-67 | 666.78 | p-Rb(S807/S811) | 38.55 | p-cJun(S73) | 82.82 | 2 | WM115-signal3 | C4 | |
| JNK-IN-8 | WM-115 | 0.0082 | uM | 24 | hr | | Ki-67 | 780.27 | p-Rb(S807/S811) | 73.45 | p-cJun(S73) | 43.18 | 1 | WM115-signal3 | D9 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.8000 | uM | 24 | hr | | Ki-67 | 744.48 | p-Rb(S807/S811) | 42.82 | p-cJun(S73) | 20.07 | 1 | WM115-signal3 | F4 |
| JNK-IN-8 | WM-115 | 0.0512 | uM | 24 | hr | | Ki-67 | 765.62 | p-Rb(S807/S811) | 80.82 | p-cJun(S73) | 36.31 | 2 | WM115-signal3 | E7 | |
| JNK-IN-8 | WM-115 | 0.3200 | uM | 24 | hr | | Ki-67 | 785.96 | p-Rb(S807/S811) | 71.52 | p-cJun(S73) | 21.74 | 2 | WM115-signal3 | E5 | |
| Vemurafenib | WM-115 | 0.3200 | uM | 24 | hr | | Ki-67 | 721.37 | p-Rb(S807/S811) | 38.52 | p-cJun(S73) | 78.48 | 1 | WM115-signal3 | B5 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0000 | uM | 24 | hr | | Ki-67 | 696.53 | p-Rb(S807/S811) | 75.37 | p-cJun(S73) | 50.95 | 2 | WM115-signal3 | G11 |
| Vemurafenib | WM-115 | JNK-IN-8 | 2.0000 | uM | 24 | hr | | Ki-67 | 657.65 | p-Rb(S807/S811) | 46.72 | p-cJun(S73) | 17.87 | 2 | WM115-signal3 | G3 |
| JNK-IN-8 | WM-115 | 0.0205 | uM | 24 | hr | | Ki-67 | 755.77 | p-Rb(S807/S811) | 76.94 | p-cJun(S73) | 41.65 | 1 | WM115-signal3 | D8 | |
| JNK-IN-8 | WM-115 | 0.0512 | uM | 24 | hr | | Ki-67 | 781.07 | p-Rb(S807/S811) | 77.07 | p-cJun(S73) | 34.92 | 1 | WM115-signal3 | D7 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0082 | uM | 24 | hr | | Ki-67 | 732.41 | p-Rb(S807/S811) | 74.91 | p-cJun(S73) | 46.30 | 2 | WM115-signal3 | G9 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0512 | uM | 24 | hr | | Ki-67 | 863.33 | p-Rb(S807/S811) | 76.07 | p-cJun(S73) | 41.68 | 1 | WM115-signal3 | F7 |
| JNK-IN-8 | WM-115 | 0.1280 | uM | 24 | hr | | Ki-67 | 843.01 | p-Rb(S807/S811) | 77.92 | p-cJun(S73) | 26.33 | 1 | WM115-signal3 | D6 | |
| JNK-IN-8 | WM-115 | 2.0000 | uM | 24 | hr | | Ki-67 | 790.07 | p-Rb(S807/S811) | 77.44 | p-cJun(S73) | 19.89 | 1 | WM115-signal3 | D3 | |
| Vemurafenib | WM-115 | 0.0082 | uM | 24 | hr | | Ki-67 | 730.04 | p-Rb(S807/S811) | 70.31 | p-cJun(S73) | 48.98 | 2 | WM115-signal3 | C9 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0033 | uM | 24 | hr | | Ki-67 | 698.42 | p-Rb(S807/S811) | 71.10 | p-cJun(S73) | 47.45 | 2 | WM115-signal3 | G10 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.8000 | uM | 24 | hr | | Ki-67 | 682.82 | p-Rb(S807/S811) | 40.64 | p-cJun(S73) | 20.31 | 2 | WM115-signal3 | G4 |
| JNK-IN-8 | WM-115 | 0.0000 | uM | 24 | hr | | Ki-67 | 735.15 | p-Rb(S807/S811) | 75.29 | p-cJun(S73) | 50.13 | 2 | WM115-signal3 | E11 | |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0205 | uM | 24 | hr | | Ki-67 | 796.29 | p-Rb(S807/S811) | 74.93 | p-cJun(S73) | 42.86 | 2 | WM115-signal3 | G8 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0205 | uM | 24 | hr | | Ki-67 | 795.90 | p-Rb(S807/S811) | 74.91 | p-cJun(S73) | 44.16 | 1 | WM115-signal3 | F8 |
| Vemurafenib | WM-115 | 5.0000 | uM | 24 | hr | | Ki-67 | 691.81 | p-Rb(S807/S811) | 49.35 | p-cJun(S73) | 49.25 | 1 | WM115-signal3 | B2 | |
| JNK-IN-8 | WM-115 | 0.0205 | uM | 24 | hr | | p27 Kip1 | 228.02 | p-Rb(S807/S811) | 77.98 | p-ERK(T202/Y204) | 657.81 | 2 | WM115-signal1 | E8 | |
| JNK-IN-8 | WM-115 | 0.0000 | uM | 24 | hr | | p27 Kip1 | 225.01 | p-Rb(S807/S811) | 72.59 | p-ERK(T202/Y204) | 628.25 | 2 | WM115-signal1 | E11 |