Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | WM-115 | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 173.97 | p-Rb(S807/S811) | 36.66 | p-S6(S235/S236 | 72.75 | 2 | WM115-signal2 | G5 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 183.28 | p-Rb(S807/S811) | 55.71 | p-S6(S235/S236 | 111.37 | 2 | WM115-signal2 | G6 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 179.49 | p-Rb(S807/S811) | 67.38 | p-S6(S235/S236 | 142.55 | 2 | WM115-signal2 | G7 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 202.11 | p-Rb(S807/S811) | 70.44 | p-S6(S235/S236 | 160.70 | 2 | WM115-signal2 | G8 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 181.02 | p-Rb(S807/S811) | 67.72 | p-S6(S235/S236 | 155.98 | 2 | WM115-signal2 | G9 |
| Vemurafenib | WM-115 | 0.0033 | uM | 24 | hr | | Ki-67 | 734.74 | p-Rb(S807/S811) | 72.53 | p-cJun(S73) | 47.91 | 1 | WM115-signal3 | B10 | |
| Vemurafenib | WM-115 | 0.0000 | uM | 24 | hr | | Ki-67 | 738.43 | p-Rb(S807/S811) | 73.77 | p-cJun(S73) | 49.75 | 1 | WM115-signal3 | B11 | |
| Vemurafenib | WM-115 | 5.0000 | uM | 24 | hr | | Ki-67 | 691.81 | p-Rb(S807/S811) | 49.35 | p-cJun(S73) | 49.25 | 1 | WM115-signal3 | B2 | |
| Vemurafenib | WM-115 | 2.0000 | uM | 24 | hr | | Ki-67 | 671.20 | p-Rb(S807/S811) | 44.63 | p-cJun(S73) | 68.10 | 1 | WM115-signal3 | B3 | |
| Vemurafenib | WM-115 | 0.8000 | uM | 24 | hr | | Ki-67 | 663.63 | p-Rb(S807/S811) | 39.63 | p-cJun(S73) | 79.94 | 1 | WM115-signal3 | B4 | |
| Vemurafenib | WM-115 | 0.3200 | uM | 24 | hr | | Ki-67 | 721.37 | p-Rb(S807/S811) | 38.52 | p-cJun(S73) | 78.48 | 1 | WM115-signal3 | B5 | |
| Vemurafenib | WM-115 | 0.1280 | uM | 24 | hr | | Ki-67 | 784.48 | p-Rb(S807/S811) | 55.88 | p-cJun(S73) | 67.92 | 1 | WM115-signal3 | B6 | |
| Vemurafenib | WM-115 | 0.0512 | uM | 24 | hr | | Ki-67 | 753.40 | p-Rb(S807/S811) | 69.46 | p-cJun(S73) | 57.69 | 1 | WM115-signal3 | B7 | |
| Vemurafenib | WM-115 | 0.0205 | uM | 24 | hr | | Ki-67 | 780.78 | p-Rb(S807/S811) | 72.14 | p-cJun(S73) | 50.93 | 1 | WM115-signal3 | B8 | |
| Vemurafenib | WM-115 | 0.0082 | uM | 24 | hr | | Ki-67 | 788.63 | p-Rb(S807/S811) | 73.58 | p-cJun(S73) | 49.70 | 1 | WM115-signal3 | B9 | |
| Vemurafenib | WM-115 | 0.0033 | uM | 24 | hr | | Ki-67 | 706.27 | p-Rb(S807/S811) | 71.35 | p-cJun(S73) | 46.99 | 2 | WM115-signal3 | C10 | |
| Vemurafenib | WM-115 | 0.0000 | uM | 24 | hr | | Ki-67 | 699.08 | p-Rb(S807/S811) | 74.05 | p-cJun(S73) | 48.96 | 2 | WM115-signal3 | C11 | |
| Vemurafenib | WM-115 | 5.0000 | uM | 24 | hr | | Ki-67 | 635.32 | p-Rb(S807/S811) | 49.14 | p-cJun(S73) | 49.50 | 2 | WM115-signal3 | C2 | |
| Vemurafenib | WM-115 | 2.0000 | uM | 24 | hr | | Ki-67 | 688.19 | p-Rb(S807/S811) | 44.09 | p-cJun(S73) | 69.41 | 2 | WM115-signal3 | C3 | |
| Vemurafenib | WM-115 | 0.8000 | uM | 24 | hr | | Ki-67 | 666.78 | p-Rb(S807/S811) | 38.55 | p-cJun(S73) | 82.82 | 2 | WM115-signal3 | C4 | |
| Vemurafenib | WM-115 | 0.3200 | uM | 24 | hr | | Ki-67 | 587.55 | p-Rb(S807/S811) | 26.27 | p-cJun(S73) | 71.93 | 2 | WM115-signal3 | C5 | |
| Vemurafenib | WM-115 | 0.1280 | uM | 24 | hr | | Ki-67 | 771.14 | p-Rb(S807/S811) | 55.68 | p-cJun(S73) | 62.70 | 2 | WM115-signal3 | C6 | |
| Vemurafenib | WM-115 | 0.0512 | uM | 24 | hr | | Ki-67 | 678.09 | p-Rb(S807/S811) | 65.24 | p-cJun(S73) | 51.35 | 2 | WM115-signal3 | C7 | |
| Vemurafenib | WM-115 | 0.0205 | uM | 24 | hr | | Ki-67 | 761.10 | p-Rb(S807/S811) | 71.98 | p-cJun(S73) | 49.80 | 2 | WM115-signal3 | C8 | |
| Vemurafenib | WM-115 | 0.0082 | uM | 24 | hr | | Ki-67 | 730.04 | p-Rb(S807/S811) | 70.31 | p-cJun(S73) | 48.98 | 2 | WM115-signal3 | C9 |